廖宜真(Liao, Yi-Jen ) 教授

Email
yjliao@tmu.edu.tw
現   職
醫學檢驗暨生物技術學系 教授

學經歷

學 歷

畢業學校與學位[修業時間]
陽明大學公共衛生學研究所 博士
2005/09~2010/07
台灣大學流行病學研究所 碩士
2002/09~2004/06
高雄醫學大學公共衛生學系 學士
1999/09~2002/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系教授
2021/02/01~
醫學檢驗暨生物技術學系副教授
2017/02/01~2021/01/31
醫學檢驗暨生物技術學系助理教授
2012/10/01~2017/01/31
醫學檢驗暨生物技術學系助理研究員
2012/08/23~2012/09/30

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學生物科技博士學位學程籌備處助理教授
2015/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
國立陽明大學博士後研究
2010/09~2012/07/31

專長與研究領域

學門領域
寄生蟲學、醫事技術及實驗診斷
學術專長

論文著作

清冊下載


1. 2024 Suk FM ,Hsu FY,Hsu MH,Chiu WC,Fang CC,Chen TL, Liao YJ*. Treatment with a new barbituric acid derivative suppresses diet-induced metabolic dysfunction and non-alcoholic fatty liver disease in mice . Life Sciences .2024 ;(336)

2. 2024 Hsu FY,Yang SC,Suk FM, Hitoshi Shirakawa,Chiu WC* ,Liao YJ*. Dietary rice bran attenuates hepatic stellate cell activation and liver fibrosis in mice through enhancing antioxidant ability . The Journal of Nutritional Biochemistry .2024 ;(125)

3. 2024 Shih MS,Suk FM,Chiu WC,Lee CY,Hsu FY,Liao YJ*. Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma . Ecotoxicology and Environmental Safety .2024 ;(273)

4. 2023 Suk FM ,Hsu FY,Lee YC,Chen TL,Chiu WC ,Liao YJ*. Dietary oxidized frying oil activates hepatic stellate cells and accelerates the severity of carbon tetrachloride- and thioacetamide-induced liver fibrosis in mice . Journal of Nutritional Biochemistry .2023 ;(115):1-9

5. 2023 Suk FM ,Wu CY,Fang CC,Chen TL,Liao YJ*. β-HB treatment reverses sorafenib resistance by shifting glycolysis–lactate metabolism in HCC . Biomedicine & Pharmacotherapy .2023 ;(166)

6. 2023 Liao YJ,Lee CY,Twu YC,Suk FM,Lai TC,Chang YC, Lai YC, Yuan JW, Jhuang HM, Jian HR, Huang LC, Chen KP*, Hsu MH*. Isolation and Biological Evaluation of Alfa-Mangostin as Potential Therapeutic Agents against Liver Fibrosis . Bioengineering .2023 ;(10)

7. 2022 Suk FM ,Wu CY,Chiu WC ,Chien CY,Chen TL,Liao YJ*. HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells . molecules .2022 ;(27):1-15

8. 2021 Liao YJ*, Wang YH, Wu CY, Hsu FY, Chien CY, Lee YC . Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl4 and TAA-Induced Liver Fibrosis in Mice . Int. J. Mol. Sci. .2021 ;(22):1-15

9. 2021 Wu YX, Lu HF, Lin YH, Chuang HY, Su SC*, Liao YJ*, Twu YC* . Branched I antigen regulated cell susceptibility against natural killer cytotoxicity through its N-linked glycosylation and overall expression . Glycobiology .2021 ;(31):624-635

10. 2021 Suk FM ,Wang YH,Chiu WC ,Liu CF ,Wu CY ,TL Chen, YJ Liao*. Secretory NPC2 Protein-Mediated Free Cholesterol Levels Were Correlated with the Sorafenib Response in Hepatocellular Carcinoma. . International journal of molecular sciences .2021 ;(22):1-15

11. 2020 Wang YH,Suk FM,Liu CL,Chen TL,Twu YC,Hsu MM, Liao YJ. Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-kB Signaling Pathway in Hepatic Stellate Cells . Frontiers in Pharmacology .2020 ;(11):1-15

12. 2020 Lee CY,Suk FM,YC Twu,Liao YJ*. Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Fibrosis . Int. J. Environ. Res. Public Health .2020 ;(17):1-13

13. 2020 Liao YJ ,Hsu SM ,Chien CY ,Wang YH ,Hsu MH *,Suk FM *. Treatment with a New Barbituric Acid Derivative Exerts Antiproliferative and Antimigratory Effects Against Sorafenib Resistance in Hepatocellular Carcinoma. . Molecules .2020 ;(25):1-17

14. 2020 Wang YH,Suk FM,Liao YJ*. Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer . Cancers .2020

15. 2020 Yang CY,Fan MH,Miao CH,Liao YJ,Yuan RH,Liu CL. Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer . Molecular Therapy Oncolytics .2020

16. 2020 Chen YJ,Liao YJ , Ngoc VT Tram,Lin CH,Liao KC,Liu CL. Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases. . Life .2020 ;(246)

17. 2020 Liao YJ ,Wang YH,Liu CL,Fang CC,Hsu MH*,Suk FM*. 4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways . Applied Sciences .2020

18. 2019 Chen JC,Chuang HY,Liao YJ,Hsu FT,Chen YC,Wang WH, Hwang JJ.. Enhanced cytotoxicity of human hepatocellular carcinoma cells following pretreatment with sorafenib combined with trichostatin A. . Oncol Lett. .2019 ;(17):638-645

19. 2019 Mao TL,Miao CH,Liao YJ,Chen YJ,Yeh CY,Liu CL. Ex Vivo Expanded Human Vγ9Vδ2 T-Cells Can Suppress Epithelial Ovarian Cancer Cell Growth . Int J Mol Sci. .2019 ;(20):1139--1149

20. 2019 Suk FM,Liu CL,Hsu MH,Chuang YT,Wang P,Liao YJ. Treatment with a new benzimidazole derivative bearing a pyrrolidine side chain overcomes sorafenib resistance in hepatocellular carcinoma . Scientific reports .2019 ;(9):1-10

21. 2019 Wang YH,Liu CL,Chiu WC,Twu YC, Liao YJ. HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma . cancers .2019 ;(11):1-18

22. 2018 Chin-Han Huang,Yi-Jen Liao,Ting-Hsi Fan,Tzeon-Jye Chiou,Yen-Hsi Lin,Yuh-Ching Twu. A Developed NK-92MI Cell Line with Siglec-7neg Phenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells . Int. J. Mol. Sci. .2018 ;(19):1073-1087

23. 2018 AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage . Scientific Reports .2018 ;(14)

24. 2018 Wang YH,Twu YC,Wang CK,Lin FZ,Lee CY,Liao YJ. Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function . Int J Mol Sci. .2018 ;(19): 1-15

25. 2017 Yen CH,Lai CC,Liao CC,Wang SF,Liao YJ,Tung CY, Hung SF, Chen YM. Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development . Scientific Report .2017 ;(7):3052

26. 2017 Yu CY,Chou WT,Liao YJ,Lee JH,Liang JA,Hsu SM. Impact of radiation attenuation by a carbon fiber couch on patient dose verification . Sci Rep .2017 ;(7):43336

27. 2017 Hsu MH,Hsu SM,Kuo YC,Liu CY,Hsieh CY,Twu YC, Wang CK, Wang YH, Liao YJ*. Treatment with low-dose sorafenib in combination with a novel benzimidazole derivative bearing a pyrolidine side chain provides synergistic antiproliferative effects against human liver cancer . RSC Advances .2017 ;(7):16253-16263

28. 2017 Lee YH,Liao YJ,Huang CH,Chang FL,Fan TH,Twu YC. Branched I antigens on leukemia cells enhanced sensitivity against natural killer–cell cytotoxicity through affecting the target–effector interaction . Transfusion .2017 ;(57):1040-1051

29. 2017 Hsu SM,Hung CH,Liao YJ,Fu HM,Tsai JT,Huang YH, Huang David YC*. Feasibility Study on Applying Radiophotoluminescent Glass Dosimeters for CyberKnife SRS Dose Verification . PLoS One .2017 ;(12):e01692

30. 2016 Hsu SM,Wang SF,Hsieh YJ,Cheng CC,Liao YJ. The Physical and Biomedical Characteristics of the Novel Transmission Type X-ray Equipment . Radiation measurements .2016 ;(90):238-241

31. 2016 Chuang H,Huang LC,Kapoor M,Liao YJ,Yang CL,Chang CC, Wu CY, Hwu JR, Huang TJ and Hsu MH. Design and synthesis of pyridine-pyrazole-sulfonate derivatives as potential anti-HBV agents. . MedChemComm .2016 ;(7):832-836

32. 2016 Twu YC,Lee TS,Hsu SM,Wang YH,Liao CY,Wang CK, Liang YC, Liao YJ*.. Niemann-Pick type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation . International journal of molecular sciences .2016 ;(17):1122

33. 2016 Liao YJ,Lee TS,Twu Y,Hsu SM,Yang CP,Wang CK, Liang YC, Chen YM*.. Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver. . Journal of Biomedical Science .2016 ;(23):69-77

34. 2016 Liao YJ,Lee YH,Chang FL,Ho H,Huang CH,Twu YC*. The SHP-2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of C/EBPα to the IGnTC promoter region during erythroid differentiation. . Transfusion .2016

35. 2016 Wu CH,Liao YJ,Lin TY,Chen YC,Sun SS,Liu YWH, Hsu SM. A Volume-Equivalent Spherical Necrosis-Tumor-Normal Liver Model for Estimating Absorbed Dose in Yttrium-90 Microsphere Therapy . MEDICAL PHYSICS .2016

36. 2015 Lee JH,Chang LT,Shiau AC,Chen CW,Liao YJ,Li WJ, Lee MS, Hsu SM. A Novel Simple Phantom for Verifying the Dose of Radiation Therapy . J. Biomedicine and Biotechnology .2015

37. 2015 Liao YJ,Fang CC,Yen CH,Hsu SM,Wang CK,Huang SF, Liang YC, Lin YY, Chu YT and Chen YM. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications . international journal of cancer .2015

38. 2015 Hou, HH,Liao, YJ,Hsiao, SH,Shyue, SK,Lee, TS. Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase . Scientific report .2015 ;(5):13524

39. 2015 Wu CH,Liao YJ,Shiau AC,Lin HY,Hsueh Liu YW,Hsu SM. HDR Brachytherapy Dose Distribution is Influenced by the Metal Material of the Applicator . Scientific report .2015

40. 2015 Lin YT,Yen CH,Chen HL,Liao YJ,Lin IF,Chen M, YC Lan, SY Chuang, SL Hsieh, YM Arthur Chen. The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients . Journal of the Formosan Medical Association .2015 ;(114):498-503

41. 2014 Wu CH,Shiau AC,Liao YJ,Lin HY,Liu YWH,Hsu SM. Influence of Metal of the Applicator on the Dose Distribution during Brachytherapy . PLOS ONE (10.1371/journal.pone.0104831) .2014

42. 2014 Wu CH,Liao YJ,Liu YWH,Hung SK,Lee MS,Hsu SM. Dose Distributions of an 192Ir Brachytherapy Source in Different Media . JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (Article ID: 946213, 11 Pages) .2014

43. 2013 Chen YM,Liao YJ. Phosphorylated forms of GNMT in mouse liver . Journal of Proteomics .2013

44. 2013 Liao YJ,Lin MW,Yen CH,Lin YT,Wang CK,Huang SF, Chen KH, Yang CP, Chen TL, Hou MF, Arthur Chen YM.. Characterization of Niemann-Pick Type C2 Protein Expression in Multiple Cancers Using a Novel NPC2 Monoclonal Antibody . PLoS One .2013 ;(8):1-11

45. 2013 Lin IY,Yen CH,Liao YJ,Lin SE,Ma HP,Chan YJ, Chen YM. Identification of FKBP11 as a biomarker for hepatocellular carcinoma . Anticancer Res. .2013 ;(33):2763-2769

46. 2012 Liao YJ,Chen TL,Lee TS,Wang CK,Liao LY,Wang HA, Liu RS, Huang SF, Lin CH, and Chen YM*. Glycine N-methyltransferase deficiency affects Niemann-Pick Type C2 protein stability and regulates hepatic cholesterol homeostasis. . Molecular Medicine .2012 ;(18):412-422

47. 2012 Chen CY,Ching LC,Liao YJ,Yu YB,Tsou CY,Shyue SK, Chen YM* and Lee TS*. Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice. . Molecular Medicine .2012 ;(18):744-752

48. 2012 Hsu SM,Wu CH,Lee JH,Hsieh YJ,Yu CY,Liao YJ, Kuo LC, Liang*JA, Huang David Y. C*. A study on the dose distributions in various materials from an Ir-192 HDR brachytherapy source . PLOS ONE .2012 ;(7):e44528-10

49. 2011 Lee MS,Liao YJ,Huang YH,Lee JH,Hung SK,Chen TR, Hsu SM*. Radiation characteristics of homemade radiophotoluminescent glass dosimeter . Radiat. Meas. .2011 ;(46):1477-1479

50. 2011 Liu SP,Li YS,Lee CM,Yen CH,Liao YJ,Huang SF, Chien CH, Chen YM*. Higher susceptibility to aflatoxin B1-related hepatocellular carcinoma in glycine N-Methyltransferase knockout mice. . Int. J. Cancer .2011 ;(128):511-523

51. 2011 Hsu SM,Lee JH,Hsu FY,Lee HW,Hung SK,Liao YJ, Lee MS*. Dose measurements for gamma knife with radiophotoluminescent glass dosimeter and radiochromic film . Radiat. Prot. Dosim. .2011 ;(146):256-259

52. 2010 Liao YJ,Chen KH,Huang SF,Chen TL,Wang CK,Chien CH, Tsai TF, Liu SP, Chen YM*. Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver . Proteom. Clin. Appl. .2010 ;(4):394-406

53. 2010 Hsu SM,Yang HW,Huang YH,Lee JH,Yu CY,Liao YJ, Hung SK, Lee MS*. Chemical and physical characteristics of self-fabricated radiophotoluminescent glass dosimeter. . Radiat. Meas. .2010 ;(45):553-555

54. 2009 Liao YJ,Liu SP,Lee CM,Yen CH,Chuang PC,Chen CY, Tsai TF, Huang SF, Wu YH, Chen YM*. Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma . Int. J. Cancer .2009 ;(124):816-826

55. 2009 Chen YM,Liao YJ,Liu SP,Tsai TF. Phenotypic differences of two GNMT-/- mouse model for hepatocellular carcinoma . Hepatology .2009 ;(49):2130-2131

研究計畫

計畫名稱
113 探討FGF21表現對於肝硬化之性別差異的影響及其分子調控機制
補助單位
國家科學及技術委員會

計畫名稱
112 探討Developmentally regulated endothelial cell locus-1(Del-1)在 調控肝星狀細胞活化與肝纖維化的角色
補助單位
國家科學及技術委員會

計畫名稱
112 探討HMGCS2基因調控酮體生成與能量代謝轉換對抗藥性肝癌之影響(2/2)
補助單位
國家科學及技術委員會

計畫名稱
112 亞太肝臟研究協會 腫瘤學 2023-許芳瑜
補助單位
國家科學及技術委員會

計畫名稱
111 探討肝癌細胞長期暴露低劑量塑化劑後對sorafenib感受性的影響及其分子機制
補助單位
國家科學及技術委員會

計畫名稱
111 探討HMGCS2基因調控酮體生成與能量代謝轉換對抗藥性肝癌之影響(1/2)
補助單位
國家科學及技術委員會

計畫名稱
111 新加坡肝臟學會議2023(研究生:醫學檢驗暨生物技術學系碩士班吳芊瑩君)
補助單位
國家科學及技術委員會

計畫名稱
110 長期暴露低劑量塑化劑對肝癌藥物 (sorafenib)感受性的影響
補助單位
國家科學及技術委員會

計畫名稱
110 探討NPC2基因調控肝癌細胞內游離型膽固醇恆定在sorafenib抗藥性之角色(3/3)
補助單位
科技部

計畫名稱
109 探討酮體對肝癌細胞sorafenib感受性影響
補助單位
科技部

計畫名稱
109 探討NPC2基因調控肝癌細胞內游離型膽固醇恆定在sorafenib抗藥性之角色(2/3)
補助單位
科技部

計畫名稱
108 探討NPC2基因調控肝癌細胞內游離型膽固醇恆定在sorafenib抗藥性之角色(1/3)
補助單位
科技部

計畫名稱
107 研究NPC2蛋白抑制肝星狀細胞活化的機制與治療肝纖維化
補助單位
科技部

計畫名稱
106 Study the mechanisms of novel benzimidazole derivative in the sorafenib-resistance liver cancer cell
補助單位
科技部

計畫名稱
106 研究NPC2基因在調控肝星狀細胞活化與肝纖維化的角色
補助單位
科技部

計畫名稱
105 探討新型benzimidazole衍生物抑制肝癌抗藥性細胞生長的角色
補助單位
科技部

計畫名稱
105 研究NPC2蛋白抑制肝細胞增生與癌化的機制(3/3)
補助單位
科技部

計畫名稱
105 研究NPC2蛋白抑制肝細胞增生與癌化的機制(3/3)
補助單位
科技部

計畫名稱
104 Synergistic Effects of Benzimidazole Derivative and Sorafenib in Liver Cancer Cells
補助單位
科技部

計畫名稱
104 研究NPC2蛋白抑制肝細胞增生與癌化的機制(2/3)
補助單位
科技部

計畫名稱
104 研究NPC2蛋白抑制肝細胞增生與癌化的機制(2/3)
補助單位
科技部

計畫名稱
103 研究NPC2蛋白抑制肝細胞增生與癌化的機制(1/3)
補助單位
科技部

計畫名稱
103 研究NPC2蛋白抑制肝細胞增生與癌化的機制(1/3)
補助單位
科技部

計畫名稱
103 探討NPC2基因在肝臟星狀細胞活化時所扮演的角色
補助單位
科技部

計畫名稱
102 評估transmission type X-ray合併Rose Bengal治療肝癌的效果
補助單位
和鑫生技開發股份有限公司

計畫名稱
102 EVALUATION THE THERAPEUTIC EFFICIENCY OF ROSE BENGAL COMBINED WITH TRANSMISSION TYPE X-RAY IN LIVER IN LIVER CANCER (A102-077)
補助單位
和康生物科技股份有限公司

計畫名稱
102 利用肝毒物誘發小鼠肝纖維化來探討NPC2(NIEMANN-PICK DISEASE, TYPE C2)的表現
補助單位
科技部

計畫名稱
102 探討NPC2蛋白在肝癌形成過程中所扮演的角色(2/2)
補助單位
行政院國家科學委員會

計畫名稱
102 探討NPC2蛋白在肝癌形成過程中所扮演的角色(2-2)
補助單位
科技部

計畫名稱
101 探討NPC2蛋白在肝癌形成過程中所扮演的角色(1/2)
補助單位
行政院國家科學委員會

計畫名稱
101 TMU101-AE1-B29
補助單位
學校