林榮俊(Lin, Jung-Chun) 教授

Email
lin2511@tmu.edu.tw
現   職
醫學檢驗暨生物技術學系 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立台灣大學分子醫學研究所 博士
2004/09~2008/01
國立陽明大學解剖暨細胞生物學研究所 碩士
2002/09~2004/06
臺北醫學大學醫事技術學系 學士
1993/09~1997/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系教授
2019/02/01~
醫學檢驗暨生物技術學系副教授
2016/02/01~2019/01/31
醫學檢驗暨生物技術學系助理教授
2012/02/29~2016/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
臨床基因體學暨蛋白質體學碩士學位學程教授
2022/12/01 ~
醫學生物科技博士學位學程籌備處助理教授
2015/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院博士後研究
2008/02/01~2012/02/28
國家衛生研究院研究助理
2001/01/31~2002/06/30
中央研究院研究助理
1999/08/01~2000/12/31

專長與研究領域

學門領域
Post transcriptional regulation/RNA metabolism
Function of RNA binding protein
RNA alternative splicing
學術專長
qRT-PCR
RT-PCR
Western/Northern/Southern Blotting
Molecular cloning
Transfection
Gene knockout

論文著作

清冊下載


1. 2024 Yu MC,Huang CK,Hung CS,Lin JC. Emerging insight of whole genome sequencing coupled with protein structure prediction into the pyrazinamide-resistance signature of Mycobacterium tuberculosis . International Journal of Antimicrobial Agents .2024

2. 2023 Wu CY,Huang CK,Hong WS,Liu YH,Shih MC,Lin JC. Influence of Symbiotic Fermentation Broth on Regulating Metabolism with Gut Microbiota and Metabolite Profiles Is Estimated Using a Third-Generation Sequencing Platform . Metabolites .2023

3. 2022 Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay. . Microbiology Spectrum .2022

4. 2022 Exploring gut microenvironment in colorectal patient with dual-omics platform: A comparison with adenomatous polyp or occult blood . Biomedicines .2022

5. 2022 Chen TS,Cheng CY,Huang CK,Ho YH,Lin JC. Exploring the relevance between gut microbiota-metabolites profile and chronic kidney disease with distinct pathogenic factor . Microbiology Spectrum .2022

6. 2021 Lin YC,Chen TS,Huang YM,Wei PL,Lin JC. Involvement of microRNA in solid cancer: role and regulatory mechanisms . Biomedicines .2021

7. 2021 Chen TH,Liu CW,Ho YH,Huang CK,Hung CS,Barry HS, Lin JC. Gut Microbiota Composition and Its Metabolites in Different Stages of Chronic Kidney Disease . Journal of Clinical Medicine .2021

8. 2021 Yu MC,Hung CS,Huang CK,Wang CH,Liang YC,Lin JC. Integrative utility of long read sequencing-based whole genome analysis and phenotypic assay on differentiating isoniazid-resistant signature of Mycobacterium tuberculosis . Journal of Biomedical Science .2021

9. 2020 Lin YC,Lu, YH,Lee, YC,Hung, CS,Lin, JC. Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism . BBA-Gene Regulatory Mechanisms .2020 ;(1863):1863-1874

10. 2020 Wei PL,Hung CS,Kao YW,Lin YC,Lee CY,Chang TH, Shia BC, Lin JC. Characterization of fecal microbiota with clinical specimen using long-read and short-read sequencing platform . International Journal of Molecular Sciences .2020

11. 2020 Chen YS,Liu CW,Lin YC,Tsai CY,Yang CH,Lin JC. The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism . Neoplasia .2020

12. 2020 Wei PL,Hung CS,Kao YW,Lin YC,Lee CY,Chang TH, Shia BC, Lin JC. Classification of changes in the fecal microbiota associated with colonic adenomatous polyps using a long-read sequencing platform . Genes .2020

13. 2019 Lin YC,Lee YC,Lin YJ,Lin JC. Berberine Promotes Beige Adipogenic Signatures of 3T3-L1 Cells by Regulating Post-transcriptional Events . Cells .2019 ;(8):632-646

14. 2019 Chang HL,Lin JC. SRSF1 and RBM4 differentially modulate the oncogenic effect of HIF-1alpha in lung cancer cells through alternative splicing mechanism . BBA - Molecular Cell Research .2019 ;(1866):118550

15. 2019 Hung CS,Lin JC. Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis . BBA - Gene Regulatory Mechanisms .2019

16. 2018 Peng HY,Liang YC,Tan TH,Chuang HC,Lin YJ,Lin JC. RBM4a-SRSF3-MAP4K4 splicing cascade constitutes a molecular mechanism for regulating brown adipogenesis . International Journal of Molecular Sciences .2018 ;(19):2646-2661

17. 2018 Tsai FJ,Ho MW,Lai CH,Chou CH,Li JP,Cheng CF, Wu YC, Liu X, Tsang H, Lin TH, Liao CC, Huang SM, Lin JC, Lin CC, Hsieh CL, Liang WM, Lin YJ.. Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications. . Frontiers in Pharmacology .2018

18. 2018 Lin JC. Therapeutic applications of targeted alternative splicing to cancer treatment . International Journal of Molecular Science .2018 ;(19):E75

19. 2018 Lin JC. Multi-posttranscriptional regulations lessen the repressive effect of SRPK1 on brown adipogenesis . BBA-Molecular and Cell Biology of Lipids .2018

20. 2018 Chi YL,Lin JC. RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism . BBA - Molecular Cell Research .2018 ;(1865):1515-1525

21. 2018 Tsai, Fuu-Jen,Li, Te-Mao,Cheng, Chi-Fung,Wu, Yang-Chang,Chih-Ho Lai,Ho, Tsung-Jung,Xiang Liu,Jung-Chun Lin,Lin, Ying-Ju. Effects of Chinese herbal medicine on hyperlipidemia and the risk of cardiovascular disease in HIV-infected patients in Taiwan . JOURNAL OF ETHNOPHARMACOLOGY .2018

22. 2017 Li, Te-Mao,Yu, Yang-Hao,Tsai, Fuu-Jen,Cheng, Chi-Fung,Wu, Yang-Chang,Ho, Tsung-Jung,Ting-Hsu Lin,Chiu-Chu Liao,Jung-Chun Lin,Lin, Ying-Ju. Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan . JOURNAL OF ETHNOPHARMACOLOGY .2017 ;(213):92-100

23. 2017 Huang KC,Li TM,Liu X,Chen JH,Chien WK,Shiao YT,Tsang H, Lin TH, Liao CC, Huang SM, Li JP, Lin CW, Lin JC, Lin YJ, Jen-Tsai F. KCNQ1 Variants Associate with Hypertension in Type 2 Diabetes and Affect Smooth Muscle Contractility In Vitro . Journal of Cellular Physiology .2017

24. 2017 Lin JC,Lee YC,Liang YC,Fann Yang,Kory Johnson,Lin YJ. The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells . Scientific Reports .2017 ;(7):44204-44214

25. 2017 Tsai FJ,Ho TJ,Cheng CF,Shiao YT,Chien WK,Chen JH,Liu X,Tsang HY,Lin TH,Lin JC,Ling WM,Lin YJ. Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts . Oncotarget .2017

26. 2017 Tsai FJ,Ho TJ,Cheng CF,Liu X,Tsang HY,Lin TH,Liao CC,Huang SM,Li JP,Lin CW,Lin JG,Lin JC,Lin CC,Liang WM,Lin YJ. Effect of Chinese Herbal Medicine on stroke patients with type 2 diabetes . Journal of Ethanopharmacology .2017

27. 2017 Lin JC,Lee YC,Tan TH,Liang YC,Chuang HC,Fann YC, Johnson KR, Lin YJ. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell . BBA-Molecular Cell Research .2017

28. 2016 Lin JC,Lu YH,Liu YR,Lin YJ. RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes . Scientific Reports .2016 ;(6):20665-20678

29. 2016 Lin JC,Chi YL,Peng HY,Lu YH. RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes . BBA - Gene Regulatory Mechanisms .2016

30. 2016 Lin JC,Tsao MF,Lin YJ. Differential impacts of alternative splicing networks on apoptosis . International Journal of Molecular Science .2016

31. 2016 Fuu-Jen Tsai,Tsung-Jung Ho,Chi-Fung Cheng,Yi-Tzone Shiao,Wen-Kuei Chien,Chen Jin-Hua,Xiang Liu,Jung-Chun Lin,Chih-Chien Lin,Chih-Ho Lai,Wen-Miin Liang,Ying-Ju Lin. Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts . Oncotarget .2016

32. 2015 Lin JC. RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes . RNA BIOLOGY .2015 ;(12):208-220

33. 2015 Yih-Huei Uen,Chen-Chung Liao,Jung-Chun Lin,Yi-Hsuan Pan,Yi-Chung Liu,You-Chia Chen, Wei-Jung Chen i, Chih-Chun Tai j, Kuan-Wei Lee e, Yun-Ru Liu, Ching-Yu Lin. Analysis of differentially expressed novel post-translational modifications . Journal of Proteomics .2015 ;(126):252-262

34. 2015 Lin JC. Impacts of Alternative Splicing Events on the Differentiation of Adipocytes. . International Journal of Molecular Science .2015 ;(16):22169-22189

35. 2015 Lin YJ,Chang JS,Liu X,Tsang HY,Chien WK,Chen JH,Hsieh HY,Hsueh KC,Shiao YT,Li JP,Lin CW,Lai CH,Huang SM,Lin JC,Tsai FJ. Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan . Scientific Report .2015 ;(5):14762

36. 2015 Liang YC,Lin WC,Lin YJ,Lin JC. The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. . Oncotarget .2015 ;(6):38046-38060

37. 2014 Tsai WC,Kuo TY,Lin CY,Lin JC,Chen WJ. Photobacterium damselae subsp. piscicida responds to antimicrobial peptides through phage-shock-protein A (PspA)-related extracytoplasmic stress response system . Journal of Applied Microbiology .2014 ;(118):27-38

38. 2014 Lin JC,Tarn WY,Hsieh WK. Emerging role for RNA binding motif protein 4 in the development of brown adipocytes . BBA-Molecular Cell Research .2014 ;(1843):769-779

39. 2014 Lin JC,Lin CY,Tarn WY,Li FY. Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events . RNA .2014 ;(20):1621-1631

40. 2013 Lin JC,Yan YT,Hsieh WK,Peng PJ,Su CH,Tarn WY. RBM4 promotes pancreas cell differentiation and insulin expression . Molecular and Cellular Biology .2013 ;(33):319-327

41. 2012 Lin JC,Tarn WY. Multiple roles that RBM4 plays in post-transcriptional regulation during muscle differentiation. . Frontier in Bioscience .2012 ;(4):181-189

42. 2011 Lin JC,Tarn WY. RBM4 downregulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. . J. Cell Biol. .2011 ;(193):509-520

43. 2009 Lin JC,Tarn WY. RBM4 translocates to cytoplasmic granules and suppresses translation via Ago2 during muscle cell differentiation. . J. Biol. Chem. .2009 ;(284):34658-34665

44. 2007 Lin JC,Tarn WY. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. . P.N.A.S. .2007 ;(104):2235-2240

45. 2006 Chiou S.H,Lin J.C.,Yang Y.P,Hsu C.H,Jhang H.C,Yang Y.T. Lee C.H. Ho L.L. Hsu W.M. Ku H.H. Chen S.J. Chen S.S. Chang M.D. Wu C.W. Juan. The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression . J. Immunol. .2006 ;(177):6199-6206

46. 2005 Lin JC,Tarn WY. Exon selection in α-Tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. . Mol. Cell. Biol. .2005 ;(25):10111-10121

47. 2002 Chiou S.H,Liu J.H,Chen S.S,Liu W.T,Lin J.C,Wong W.W. Tseng W.S. Chou C.K. Liu C.Y. Ho L.L. Hsu W.M. Apoptosis of human retina and retina pigment cells induced by human cytomegalovirus infection. . Ophthalmic Res. .2002 ;(34):77-82

48. 2001 1. Chiou S.H,Liu J.H,Hsu W.M,Chen S.S,Chang S.Y,Juan L.J. Lin J.C.. Yang Y.T. Wong W.W. Liu C.Y. Lin Y.S. Liu W.T. Wu C.W.. Up-regulation of Fas ligand expression by human cytomegalovirus immediate-early gene product 2: a novel mechanism in cytomegalovirus-induced apoptosis in human retina. . J. Immunol. .2001 ;(167):4098-4103


1. 2011 Chen HH,Lin JC,Tarn WY. Recent advances in understanding of alternative splicing regulation in neurons. . RNA processing .2011

研究計畫

計畫名稱
110 教育部STEM領域及女性研發人才培育計畫-延緩人體脂肪生成與累積之益生菌發酵液與其菌株之商品化開發計畫
補助單位
佰研生化科技股份有限公司

計畫名稱
110 腸道菌叢-腸道代謝體-宿主細胞轉錄後事件組成之調控網絡於維持腸道平衡或誘發腸道細胞癌化特性之探究
補助單位
科技部

計畫名稱
109 益生菌及其醱酵產物刺激腸道細胞產生血清素之研究計畫
補助單位
佰研生化科技股份有限公司

計畫名稱
108 腸道總微生物組定序應用於建構大腸直腸癌高風險族群之體外篩檢平台
補助單位
財團法人工業技術研究院

計畫名稱
108 產學合作計畫-全基因組定序用於鑑別結核桿菌抗藥性基因試劑組之開 發計畫
補助單位
科技部

計畫名稱
108 探討MBNL1與CELF1核糖核酸結合蛋白組成之基因轉錄後調控網絡於白色與棕色脂肪細胞分化與功能所扮演之角色
補助單位
科技部

計畫名稱
108 產學合作計畫-全基因組定序用於鑑別結核桿菌抗藥性基因試劑組之開 發計畫
補助單位
昕創生醫技術股份有限公司

計畫名稱
107 探討薑黃素與黃連素經由影響轉錄後調控促進棕色脂肪細胞建立之分子機制
補助單位
科技部

計畫名稱
106 探討替代性剪接機制對SRSF3與MAP4K4蛋白質亞型於棕色脂肪細胞中表現之調控與其不同亞型對棕色脂肪細胞分化與生理功能之影響
補助單位
科技部

計畫名稱
105 轉錄體分析應用於探討替代式剪接反應串聯效應對棕色脂肪細胞分化與其生理功能之影響
補助單位

計畫名稱
104 利用次世代基因定序探討剪接因子RBM4於分化中脂肪細胞所調控之替代性剪接基因與其功能之探究(2/2)
補助單位
科技部

計畫名稱
104 利用次世代基因定序探討剪接因子RBM4於分化中脂肪細胞所調控之替代性剪接基因與其功能之探究(2/2)
補助單位
科技部

計畫名稱
103 利用次世代基因定序探討剪接因子RBM4於分化中脂肪細胞所調控之替代性剪接基因與其功能之探究(1/2)
補助單位
科技部

計畫名稱
103 利用次世代基因定序探討剪接因子RBM4於分化中脂肪細胞所調控之替代性剪接基因與其功能之探究(1/2)
補助單位
科技部

計畫名稱
102 利用高解析液相串連質譜儀鑑定非小細胞性肺癌腫瘤組織與血漿檢體中多種蛋白水解酶抑制蛋白之轉譯後修飾及其應用於肺癌特異性生物標誌開發之研究
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
102 剪接因子RBM4對脂肪細胞發育調控之探究
補助單位
行政院國家科學委員會

計畫名稱
102 剪接因子RBM4對脂肪細胞發育調控之探究
補助單位
科技部