高淑慧(Kao, Shu-Huei)　教授

Email
kaosh@tmu.edu.tw
現   職
醫學科技學院 副院長
醫學檢驗暨生物技術學系 教授

學經歷

學　歷

畢業學校與學位[修業時間]
國立陽明醫學院生化學研究所 博士
1992/09/01~1998/06/01
國立陽明醫學院生化學研究所 碩士
1989/09/01~1991/06/01
私立臺北醫學院醫事技術學系 學士
1983/09/01~1987/06/01

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系教授
2019/08/01~
醫學檢驗暨生物技術學系副教授
2011/02/01~2019/07/31
醫學檢驗暨生物技術學系(舊)副教授
2008/08/01~2011/01/31
醫學檢驗暨生物技術學系(舊)助理教授
2006/08/01~2008/07/31
醫事技術學系助理教授
2004/08/18~2006/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學科技學院副院長
2023/03/01 ~
醫學檢驗暨生物技術學系主任
2017/08/01 ~ 2022/07/31
醫學生物科技博士學位學程主任
2017/08/01 ~ 2022/07/31
醫學生物科技博士學位學程籌備處副教授
2015/02/01 ~
醫學科學研究所助理教授
2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
國立台科技大學紡織系兼任助理教授
私立元培醫事技術專科學校助理教授
1998/08/01~2000/07/31
國立陽明大學生物化學科助教
1993/09~1994/06
台北榮總醫院婦產家計科研究助理
1991/08~1992/07
台北榮總醫院婦產部家計科研究助理
1987/08~1989/06

專長與研究領域

學門領域
寄生蟲學、醫事技術及實驗診斷
醫學之生化及分子生物
婦產科
小兒科
學術專長
細胞能量測定儀 (Seahorse XF24 analyzer)
粒線體功能分析 (Mitochondrial function)
粒線體基因及功能分析(Mitochondrial Genome and Fuction Analysis)
氧化性傷害分析(Oxidative damage assay)
小鼠胚胎體外受精(Mice In Vitro Fertilization)
粒線體基因檢測 (Mitochondrial genome typing)
共軛焦顯微鏡(Confocal Microscopy)
流式細胞儀 (Flow cytometry)
胚胎培養 (Embryo culture)
精子成熟及功能分析(Spermatogenesis and sperm function)
卵子生成及培養 (Oogenesis and follicle culture)
基因檢測(Genome typing)

論文著作

清冊下載

論文 Journal Paper


1. 2024 Ho NT,Ho DKN,Tomai XH,Nguyen NN,Nguyen HS,Hu YM, KaoSH, Tzeng CR. Pituitary Suppression with Gonadotropin-Releasing Hormone Agonist Prior to Artificial Endometrial Preparation in Frozen–Thawed Embryo Transfer Cycles: A Systematic Review and Meta-Analysis of Different Protocols and Infertile Populations . Biomedicines .2024 ;(12):760-760

2. 2023 Nguyen-Tuong Ho,Shu-Wei Lin,Yi-Rong Lee,Chii-Ruey Tzeng,Shu-Huei Kao . Osteopontin Splicing Isoforms Contribute to Endometriotic Proliferation, Migration, and Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells . Int. J. Mol. Sci. .2023 ;(23):15328-15328

3. 2023 Sanotra MR,Kao SH,Lee CK,Hsu CH,Huang WC,Chang TS, Tu FY, Hsu IU, Lin YF. Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer's disease . Alzheimers Res Ther .2023 ;(15):115-115

4. 2022 Renuka Sanotra M,Huang WC,Silver S,Lin CY,Chang TC,Nguyen DPQ, Lee CK, Kao SH, Shieh JCC, Lin YF.. Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer's disease . Clinical Biochemistry .2022 ;(101):26-34

5. 2021 Hwang T IS ,Chen YS,Hung CH,Sreerangaraja Urs DB,Liao TL,Lai YC, Komrskova K, Postlerová P, Lin YF, Kao SH. Genetic association in the maintenance of the mitochondrial microenvironment and sperm capacity . Oxidative Medicine and Cellular Longevity .2021 ;(2021):1-12

6. 2021 Kuo TF,Hsu SW,Huang SH,Chang C LT,Feng CS,Huang MG, Chen TY, Yang MT, Jiang ST, Wen TN, Yang CY, Huang CY, Kao SH, Tsai KC, Yang G, Yang WC. . Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy . EMBO Mol Med .2021 ;(13):e11668

7. 2021 Sanotra MR,Huang WC,Silver S,Lin CY,Chang TC,Nguyen DPQ, Lee CK, Kao SH, Shieh JCC, Lin YF. Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer's disease . Clinical Biochemistry .2021

8. 2020 Sheu JJ,Yang LY,Renuka Sanotra M,Wang ST,Lu HT,Kam RSK, Hsu IU, Kao SH, Lee CK, Shieh JCC, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease . Clinical Biochem .2020 ;(76):24-30

9. 2020 Huang CY,Hsu LH,Chen CY,Chang GC,Chang HW,Hung YM, Liu KJ, Kao SH. Inhibition of alternative cancer cell metabolism of EGFR mutated non-small cell lung cancer serves as a potential therapeutic strategy . Cancers .2020 ;(12):181-181

10. 2020 Dilip Bhargava Sreerangaraja Urs,Wen-Han Wu ,Katerina Komrskova,Pavla Postlerova ,Yung-Feng Lin ,Chii-Ruey Tzeng, Shu-Huei Kao. Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility . Int. J. Mol. Sci. .2020 ;(21):3592-3592

11. 2020 Hsu LH,Soong TC,Chu NM,Huang CY,Kao SH,Lin YF. The Inflammatory Cytokine Profile of Patients with Malignant Pleural Effusion Treated with Pleurodesis . J Clin Med .2020 ;(9):4010-4010

12. 2019 Tsai YF,Yang DJ,Ngo TH,Shih CH,Wu YF,Lee CK, Phraekanjanavichid V, Yen SF, Kao SH, Lee HM, Huang VS, Shieh JC, Lin YF. The ganglioside Hp-s1 analogue inhibits amyloidogenic toxicity in Alzheimer disease model cells . ACS Chemical Neuroscience .2019 ;(10):528-536

13. 2019 Chokchaiwong S,Kuo YT,Hsu SP, Hsu YC,Lin SH,Zhong WB, Lin YF, Kao SH. ETF-QO Mutants uncoupled fatty acid β-oxidation and mitochondrial bioenergetics leading to lipid pathology. . Cells .2019 ;(8):1-19

14. 2019 Liao TL,Lee YC,Tzeng CR,Wang YP,Chang HY,Lin YF, Kao SH. Mitochondrial Translocation of Estrogen Receptor β Affords Resistance to Oxidative Insult-induced Apoptosis and Contributes to the Pathogenesis of Endometriosis . Free Radic Biol Med .2019 ;(134):359-372

15. 2019 Hsu LH,Feng AC,Soong TC,Ko JS,Chu NM,Lin YF, Kao SH. Clinical outcomes of chemical pleurodesis using a minocycline . Ther Adv Respir Dis .2019 ;(13):1-10

16. 2019 Ting LL,Lu HT ,Yen SF,Ngo TH,Tu FY,Tsai IS, Tsai YH, Chang FY, Li XJ, Li S, Lee CK, Kao SH, Kuo YM, Lin YF. Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer's Disease Model Cells . Mol Neurobiol .2019 ;(56):7572-7582

17. 2019 Hsu LH,Chu NM,Lin YF,Kao SH. G-Protein Coupled Estrogen Receptor in Breast Cancer . Int J Mol Sci .2019 ;(20):E306-306

18. 2018 Lin CY,Sheu JJ, Tsai IS,Wang ST,Wang ST,Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease . Clin Biochem .2018

19. 2018 Chokchaiwong S,Kuo YT,Lin SH,Hsu YC,Hsu SP,Liu YT, Chou AJ, Kao SH.. Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation . Free Radical Research .2018 ;(11):1-11

20. 2017 Hsu LH,Chu NM,Kao SH. Estrogen, Estrogen Receptor and Lung Cancer . Int. J. Mol. Sci. .2017 ;(18):1713-1713

21. 2017 Lin DS,Kao SH,Ho CS,Wei YH,Hung PL,Hsu MH, Wu TY, Wanf TJ, Jian YR, Lee TH, Chiang MF. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease . Oncotarget .2017 ;(8):73627-73639

22. 2016 Hsu LH,Hsu PC,Liao TL,Fang AC,Chu NM,Kao SH. Pleural fluid osteopontin, vascular endothelial growth factor, and urokinase-type plasminogen activator levels as predictors of pleurodesis outcome and prognosticators in patients with malignant pleural effusion: a prospective cohort study . BMC Cancer .2016 ;(16):463-463

23. 2015 Hsu LH,Liu KJ,Tsai MF,Wu CR,Feng AC,Chu NM, Kao SH.. Estrogen adversely affects the prognosis of patients with lung adenocarcinoma . Cancer Science .2015 ;(106):51-59

24. 2015 Hsu LH,Feng AC,Kao SH,Liu CC,Tsai SYC,Shih LS, Chu NM.. Second primary lung cancers among breast cancer patients treated with anti-estrogens have a longer cancer-specific survival. . Anticancer Research .2015 ;(35):1121-1127

25. 2015 Huang PT,Chen CH,Hsu IU,Salim SA,Kao SH,Cheng CW, Lai CH, Lin YF.. Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Differentiation . Plos One .2015 ;(10):e01163

26. 2015 Kao SH,Yen MY,Wang AG,Yeh YL,Lin AL.. Changes in mitochondrial morphology and bioenergetics in human lymphoblastoid cells with four novel OPA1 mutations . Invest Ophthalmo Vis SCi .2015 ;(56):2269-2278

27. 2015 Wang RS,Chang HY,Kao SH,Kao CH,Wu YC,Yeh S, Tzeng CR, Chang C.. Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice . International Journal of Molecular Science .2015 ;(16):9831-9849

28. 2015 Liao TL,Tzeng CR,Yu CL,Wang YP,Kao SH. Estrogen receptor-beta in mitochondria: implications for mitochondrial bioenergetics and tumorigenesis . Ann N Y Acad Sci .2015 ;(1350):52-60

29. 2015 Lo MC,Chen MH,Lee WS,Lu CI,Chang CR,Kao SH, Lee HM. Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy causes decreased insulin secretion from beta cells . Am J Physiol Endocrinol Metab .2015 ;(309):E829-E839

30. 2015 Kuo YT,Shih PH,Kao SH,Yeh GC,Lee HM. Pyrroloquinoline quinone resists denervation-induced skeletal muscle atrophy by activating PGC-1α and integrating mitochondrial electron transport chain complexes . Plos one .2015 ;(10):e0143600-e0143600

31. 2014 Hung KY,Liu SY,Yang TC,Liao TL,Kao SH. High-dialysate-glucose-induced oxidative stress and mitochondrial-mediated apoptosis in human peritoneal mesothelial cells . Oxidative Medicine and Cell Longivity .2014 ;(2014):01-12

32. 2014 Liao TL,Chen SC,Tzeng CR,Kao SH. TCDD Induces the Hypoxia-Inducible Factor (HIF)-1α Regulatory Pathway in Human Trophoblastic JAR Cells . International Journal of Molecular Sciences .2014 ;(15):17733-17750

33. 2013 Chang JH,Au HK,Lee WC,Chi CC,Lin TY,Wang LM, Kao SH, Huang YH, TzengCR. Expression of the pluripotent trranscription factor OCT4 promotes ell migration in endometriosis. . Fertility Sterility .2013 ;(99):1332-1339

34. 2011 Hwang TIS,Liao TL,Lin JF,Lin YC,Lee SY,Lai YC, Kao SH.. Low-Dose Testosterone treatment decreases oxidative damage in TM3 Leydig cells. . Asian J Androl. .2011 ;(13):432-437

35. 2010 Chen SC,Liao TL,Wei YH,Tzeng CR,Kao SH. Endocrine Disruptor (TCDD) Induced Mitochondrial Dysfunction and Apoptosis in Human Trophoblast-like JAR Cells. . Mol Hum Reprod .2010 ;(16):361-372

36. 2010 Lo MC,Lu CI,Chen MH,Chen CD,Lee HM,Kao SH. Glycoxidative stress-induced mitophagy modulates mitochondrial fates. . Ann. N.Y. Acad. Sci. .2010 ;(1201):1-7

37. 2009 Hung KY,,Liu SY,,Kao SH,,Huang JW,,Chiang CK,,Tsai TJ.. N-Acetylcysteine-Mediated Antioxidation Prevents Hyperglycemia-Induced Apoptosis and Collagen Synthesis in Rat Mesangial Cells. . Am J Nephrol. .2009 ;(29):192-202

38. 2008 Kao SH,Chao HT,Chen HW,Hwang TIS,Liao TL,Wei YH. Oxidative stress status in sperm with declined motility. . Fertil Steril .2008 ;(89):1183-1190

39. 2007 Chen TH,Hsu YT,Chen CH,Kao SH,Lee HM. Tanshinone IIA from Salvia miltiorrhiza Induces Heme Oxygenase-1 Expression and Inhibits Lipopolysaccharide - Induced Nitric Oxide Expression in RAW 264.7 Cells. . Mitochondrion .2007 ;(7):101-105

40. 2005 Hou, C.C.,,Hung, S.L.,,Kao, S.H.,,Chen, T.H.,,Lee, H.M.. Celecoxib Induces Heme-Oxygenase Expression in Glomerular Mesangial Cells. . Annals New York Acad Sci .2005 ;(1042):235-245

41. 2005 Kao, S.H.,,Huang,H.C.,,Hsieh R.H.,,Tsai M.C.,,Chen S.C.,,Tzeng C.R.. Oxidative Damage and Mitochondrial DNA Mutations with Endometriosis . Annals NY Acad Sci .2005 ;(1042):186-194

42. 2005 Chao, H.T.,,Lee, S.Y.,,Lee H.M.,,Liao, T.L.,Wei, Y.H.,,Kao, S.H.. Repeated Ovarian Stimulations Induce Oxidative Damages and Mitochondrial DNA Mutations in Mouse Ovaries. . Annals N.Y. Acad. Sci. .2005 ;(1042):148-156

43. 2005 Wang Y. C.,,Fu, R.H.,,Hsieh, H.J.,,Chao, H.T.,,Kao, S.H.. Polyglycolic acid/chitosan glue and apotosis of Endometriosis-derived cells. . Fertil Steril .2005 ;(84):75-81

44. 2005 Au HK,Yeh TS,Kao SH,Tzeng CR,Hsieh RH. Abnormal Mitochondrial Structure in Human Unfertilized Oocytes and Arrested Embryos . Annals New York Acad Sci .2005 ;(1042):177-185

45. 2005 Au HK,Yeh TS,Kao SH,Shih CM,Hsieh RH,Tzeng CR. Calcium-dependent up-regulation of mitochondrial electron transfer chain gene expressions in human luteinized granulosa cells. . Fert Steril .2005 ;(84):1104-1108

46. 2004 Rovio AT,,Abel J,,Ahola AL,,Andres AM,,Bertranpetit J,,Blancher A, ....Jequier AM, Kao SH, ...,Jacobs HT. A prevalent POLG CAG microsatellite length allele in humans and African great apes. . Mamm Genome .2004 ;(15):492-502

47. 2004 Kao, S.H.,,Chao, H.T.,,Liu, H.W.,,Liao, T.L,,Wei, Y.H.. Sperm mitochondrial DNA depletion in men with asthenospermia. . Fertil Steril .2004 ;(82):66-73

48. 2004 Yen MY,,Kao, SH,,Wang, AG,,Wei YH.. Increased 8-hydroxy-2'-deoxygaunosine in Leukocyte DNA in Leber's Hereditary Optic Neuropathy . Investigative Ophalmology & Visual Science .2004 ;(45):1688-1691

49. 2003 Wang YC,Kao SH,Hsieh HJ. A chemical surface modification of chitosan by glycoconjugates to enhance the cell-biomaterial interaction . Biomacromolecules .2003 ;(4):224-231

50. 2002 Wang YC,Kao SH,Hsieh HJ. A new kind therapy of endometriosis use a novel biomaterial glue . ASAIO J .2002 ;(48):190

51. 2001 Liu CS,Ko LY,Lim PS,Kao SH,Wei YH. Biomarkers of DNA damage in patients with end-stage renal disease: mitochondrial DNA mutation in hair follicle. . Nephorol Dial Transplant .2001 ;(16):561-565

52. 2001 Rovio AT,Marchington DR,Donat S,Schuppe HC,Abel J,Fritsche E, Elliott DJ, Laippala P, Ahola AL, McNay D, Harrison RF, Hughes B, Barrett T, Bailey DM, Mehmet D, Jequier AM, Hargreave TB, Kao SH, Cummins JM, Barton DE, Cooke HJ, Wei YH, Wichmann L, Poulton J, Jacobs HT. Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility. . Nature Genetics .2001 ;(29):261-262

53. 2000 Wei YH,Kao SH. Mitochondrial DNA Mutation and Depletion are associated with the decline of fertility and motility of human sperm. . Zoological Studies .2000 ;(39):1-12

54. 1998 Kao SH,Chao HT,Wei YH. Multiple deletions of mtDNA are associated with the decline of fertility and motility of human sperm. . Mol. Hum. Reprod. .1998 ;(4):657-666

55. 1998 Fahn HJ,WangLS,Chang SC,Kao SH,Huang MH,Wei YH. Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissue. . Am. J. Respir. Cell Mol. Biol. .1998 ;(19):901-909

56. 1998 Liu CS,Wu HM,Kao, SH,Wei YH. Serum trqace elements, glutathione, Cu,Zn-superoxide dismutase, and lipid peroxidation in epileptic patients with phenytoin or carbamazepine monotherapy. . Clin. Neuropharma. .1998 ;(21):62-64

57. 1997 Liu CS ,Wu HM ,Kao SH, Wei YH. Phenotoin-mediated oxidative hydantoin syndrome. . Human Exp. Toxicol. .1997 ;(16):177-181

58. 1997 Liu CS ,Kao SH ,Wei YH. Smoking-associated mitochondrial DNA mutations in human hair follicles. . Environ. Mol. Mutagen. .1997 ;(30):47-55

59. 1997 Liu CS, Yip PK ,Kao SH,Wei YH. Simultaneous declined of Mn-SOD and increase of lipid peroxidation in brain mitochondria following ischemia-reperfusion. . Mol. Biol. Biophys. .1997 ;(1):95-102

60. 1997 Kao SH ,Liu CS,Wang SY,Wei YH. Ageing-associated large-scale deletions of mitochondrial DNA in hair follicles. . Biochem. Mol. Biol. Int. .1997 ;(42):285-298

61. 1996 Fahn HJ, Wang LS ,Hiseh RH ,Chang SC ,Kao SH ,Huang MH, Wei YH. Age-related 4,977 bp deletions in human lung mitochondrial DNA. . Am. J. Respir. Crit. Care Med. .1996 ;(154):1141-1145

62. 1996 Wei YH,Kao SH,Lee HC. Simultaneous increase of mitochondrial DNA deletions and lipid peroxidation in human ageing. . Ann. New York Acad. Sci. .1996 ;(15):24-43

63. 1995 Kao SH,Chao HT,Wei YH. Mitochondrial deoxyribonucleic acid 4977-bp deletions is associated with the decline of fertility and motility of human sperm. . Biol. Reprod. .1995 ;(52):729-736

64. 1991 Chao HT,Ng HT,Kao SH,Wei YH,Hong CY. Human follicular fluid stimulates the motility of washed human sperm. . Arch. Androl. .1991 ;(26):61-65

會議論文 Conference Paper


1. 2023 Tuong NT,Hu YM,Ho YP,Lin SY,Wang RS, Lee YX, Tan SJ, Kao SH, Tzeng CR. GONADOTROPIN-RELEASING HORMONE AGONIST ADMINISTRATION PRIOR TO FROZEN-THAWED EMBRYO TRANSFER IMPROVES PREGNANCY OUTCOMES IN WOMEN WITH OVARIAN ENDOMETRIOSIS: A RETROSPECTIVE COHORT STUDY . Fertility Sterility .2023 ;(120)

2. 2023 Ho NT,Hwu YM,Ho YP,Lin SY,Wang RS,Lee YX, Tan SJ, Kao SH, Tzeng CR. ATOSIBAN MAY HAVE NO BENEFICIAL EFFECT ON EMBRYO TRANSFER OUTCOMES IN WOMEN WITHOUT UTERINE ABNORMALITIES: A PROPENSITY SCORE MATCHING STUDY . Fertility Sterility .2023 ;(120)

3. 2023 Sreerangaraja Urs DB,Wu WH,Komrskova K,Postlerova P,Lin YF,Tzeng CR, Kao SH. Mitochondrial function in modulating human granulosa cell steroidogenesis and female fertility . 2023 Annual Meeting of TSMRM Discover MITO in Human Diseases. .2023

4. 2023 Li YH,Chiang YL,Kao SH. ETFDH mutation induced generation of amyloid-β peptides of amyloid precursor proteins and cell pyroptosis contributing to Alzheimer’s disease . 2023 Annual Meeting of TSMRM, Discover MITO in Human Diseases .2023

5. 2022 Tuong HN,Hu YM,Ho YP,Wang RS,Lee YX,Tan SJ, Kao SH, Tzeng CR. Aging increases risk of delayed endometrial implantation window: An analysis using Endometrial Receptivity Array. . The 7th World Congress of the International Society for Fertility Preservation (ISFP). .2022

6. 2022 Tuong HN,Hu YM,Ho YP,Lin SY,Wang RS,Lee YX, Tan SJ, Kao SH, Tzeng CR. Combination of preimplantation genetic testing (PGT) and endometrial receptivity analysis (ERA) improves pregnancy outcomes in women with advanced age undergoing frozen-thawed embryo transfer. . The 7th World Congress of the International Society for Fertility Preservation (ISFP) .2022

7. 2021 Hsu SY,Chu PL,Kuo YT,Chen SH,Tzeng CR,Kao SH. Investigating the cytoprotective effects of mitochondrial-derived peptides on mitochondrial dysfunction. . 2021 Annual Conference of Taiwan Society for Mitochondrial Research and Medicine. .2021

8. 2020 Sreerangaraja Urs DB,Wu WH,Komrskova K,Postlerova P,Lin YF,Tzeng CR, Kao SH. Mitochondrial function in modulating human granulosa cell steroidogenesis and female fertility. . 2020 Annual Conference of Taiwan Society for Mitochondrial Research and Medicine. .2020

9. 2019 Cheng HY,Huang CY,Hsu LH,Kao SH. Minocycline potentiates the therapeutic effects of tyrosine kinase inhibitor on non-small-cell lung cancer via targeting mitochondria. . 16th conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM 2019) .2019

10. 2018 Huang CY,Hsu LH,Liu KJ,Chen CY,Kao SH. Mitochondrial translocation of EGFR promoted mitochondrial activity in gefitinib-resistant NSCLC . 1st International Mitochondria Meeting for Young Scientists .2018

11. 2018 Suphannee C,Kuo YD,Hsu YC,Hsu SP,Kao SH. ETFDH mutations perturb skeletal differentiation and impair the cross-talk between skeletal and cardiac muscle . 1st Youngmito meeting 2018 .2018

12. 2017 Huang CY,Hsu LH,Liu KJ,Chen CY,Kao SH. Blocking mitochondrial bioenergy metabolism as therapeutic target for drug-resistance in lung adenocarcinoma . 14th Conference of Asia Society of Mitochondrial Research and Medicine .2017

13. 2016 Hsu YC,Kuo YT,Chokchaiwong S,Zhong WB,Lin SH,Wang JC, Chen TY, Kao SH. ETFDH mutation induced oxidative stress leads to mitochondrial dysfunction and abnormal myogenesis . 2016 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine (TSMRM) Changhua, Taiwan .2016

14. 2015 Hsu YC,Kuo YT,Chokchaiwong S,Zhong WB,Lin SH,Wang JC, Chen TY, Kao SH. ETFDH mutation induced oxidative stress leads to mitochondrial dysfunction . The Second FHS International Conference: Gazing into the Future of Health Sciences in Asia, Hokkaido, Japan .2015

15. 2015 Lo MC,Chen MH,Chang CR,Kao SH,Lee HM. Nε-(Carboxymethyl) lysine (CML) impairs insulin secretion through ROS-mediated Drp1 overactivation . 7th Biennial Meeting of Society for Free Radical Research-Asia in Chiang Mai, Thailand. .2015

16. 2014 Lo MC,Chen MH,Lu CI,Kao SH,Lee HM. Glycoxidative stress-induced mitophagy decreases insulin secretion in pancreatic beta-cells . 17th Biennial Meeting of Society for Free Radical Research International, 2014 March 23-Mach 26, Kyoto, Japan .2014 ;(Poster):182

17. 2014 Chen YH,Wang HH,Lo CH,Yeh YL,Yen MY,Kao SH. OPA1 mutation induced oxidative insult, respiration chain uncoupling, and mitochondrial genome disintegrity . 17th Biennial Meeting of Society for Free Radical Research International, 2014 March 23-Mach 26, Kyoto, Japan .2014 ;(Poster):205

18. 2014 Chokchaiwong S,Kuo YD,Zhong WB,Lin SH,Chen YH,Wu YC, Kao SH. ETFDH mutation induced oxidative stress leads to mitochondrial dysfunction . 17th Biennial Meeting of Society for Free Radical Research International, 2014 March 23-Mach 26, Kyoto, Japan .2014 ;(Poster):206

19. 2014 Lai YT,Wei YC,Chiu YW,Ku HY,Wu YC,Chang HY, Tzeng CR, Kao SH, Tsai TF.. Cisd2 deficiency impaired sperm function and spermatogenesis . The 11th Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM), Taipei .2014

20. 2014 Chen YH,Wang HH,Lo CH,Yeh YL,Chen YC,Liu IC, Huang CY, Yen MY, Kao SH. PA1 mutation induced mitochondrial nucleoid disruption leading to mitochondrial genome instability and respiratory chain dysfunction . The 11th Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM), Taipei .2014

21. 2014 Lo MC,Chen MH,Lu CI,Kao SH,Lee HM. Nε-(carboxymethyl) lysine (CML)-induced mitophagy in pancreas of diabetic db/db mice decreased by treatment with alpha-lipoic acid . The 11th Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM), Taipei .2014

22. 2014 Ku YD,Chokchaiwong S,Lin SH,Zhong WB,Hsu YC,Wang JC, Chen TY, Kao SH. ETFDH mutation induced oxidative stress leads to mitochondrial dysfunction . 11th Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM), Taipei .2014

23. 2013 Kao SH,Yen MY,Yeh YL,Lin AL,Chen YH. OPA1 in mitochondrial structural network organization and bioenergetics. . The 6th Biennial Meeting of Society for Free Radical Research Asia, Oct. 16-19, Taoyuan, Taiwan .2013

24. 2013 Wang RS,Chang HY,Kao SH,Wu YC,Yeh SY,Tzeng CR, Chang C. Mitochondrial dysfunction in cumulus cells of androgen receptor knockout female mice. . The 10th Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM), Nov. 4-5, in Seoul, Korea, Poster .2013

25. 2012 Lin HW,Liao TL,Wu IC,Lai YT,Wang RS,Chang C, Tzeng CR, Kao SH.. Androgen receptor knockout induced mitochondrial dysfunction in mice. . 2012 Symposium ofTSMRM; 2012 Symposium of Australasian College of Medical Sciences and Research, Oct 26-27, ChangHwa, Taiwan .2012

26. 2012 Lo MC,Chen MH,Lee HM,Kao SH. Up regulation of mitochondrial dynamic proteins and autophagy in pancreas in diabetic db/db mice decreased by treatment with thio-antioxidant. . The 9th Conference of the Asian Society for Mitochondrial Research, November 2-5, 2012, Beijing, China, Poster 20. .2012

27. 2012 Lin HW,Liao TL,Wang RS,Chang C,Tzeng CR,Kao SH. Androgen receptor knockout induced mitochondrial dysfunction in mice muscle . The 9th Conference of the Asian Society for Mitochondrial Research, November 2-5, 2012, Beijing, China, Poster 14 .2012

28. 2011 Hsu LH,Liu Kj,Tsai MF,Wu CR,Hsieh SC,Chu NM. Kao SH. Estrogen Up-regulates Osteopontin Expression and Synergy with Epidermal Growth Factor Promote Lung Cancer Cell Migration. . 14th World Conference on Lung Cancer (WCLC 2011) taking place in Amsterdam, The Netherlands from 3 – 7 July. Poster 1097. .2011

29. 2011 Lo MC,Chen MH,Lu CI,Kao SH,Lee HM. Nε-(carboxymethyl) lysine (CML) impairs insulin secretion through ROS Mediated mitofusins degradation and Drp1 up-regulation. . 5th SFRR-Asia, 8th ASMRM, 11th J-mit, 2 taking place in Kagoshima, Japan from Aug 31-Sep 4. Poster 41. .2011

30. 2010 Yeh YL,Lin AL,Yen MY,Kao SH. OPA1 in the maintenance of mitochondrial bioenergetics and structural networks . The 7th Conference of the Asian Society for Mitochondrial Research and Medicine(ASMRM) and The 10th Conference of J-Mit .2010

31. 2010 Liao TL,Wang YP,Wei YH,Kao SH,Tzeng CR. Mitochondrial Estrogen Receptor β in the Modulation of Mitochondrial Transcription in Endometriosis . The 7th Conference of the Asian Society for Mitochondrial Research and Medicine(ASMRM) and The 10th Conference of J-Mit .2010

32. 2010 Kao SH,Liao TL,Wang YP,Wei YH,Tzeng CR. Estrogen receptor beta modulates mitochondrial function and biogenesis . The First Asia-Pacific Symposium on Mitochondrial Medicine and Genetic Diagnosis .2010

33. 2009 Kao SH,Hsien IG,Lee YR,Chang YF,Yen YK,Tzeng CR. Osteopontin-Modulated Endometriotic Cell Migration and Invasion . The 7th Conference of the Pacific Rim Society for Fertility and Sterility. .2009 ;(0):LBC-002

34. 2009 Chang HY,Tsai MF,Lee HM,Wei YH,Kao SH. Estrogen receptor  agonist attenuate mitochondrial biogenesis and promote cell growth in MCF-7 breast cancer cells. . 6th Conference of Asian Society for Mitochondrial Research and Medicine .2009 ;(0):PC-22

35. 2009 Liu SY,Hung YC,Chang WL,Wang YS,Kao SH. High Glucose induced human peritoneal mesothelial cell apoptosis and mitochondrial function. . 6th Conference of Asian Society for Mitochondrial Research and Medicine .2009 ;(0):PF-02

36. 2009 Kao SH,Lin AN,Chang LW,Yeh YL,Yen MY. Effects of OPA1 mutations on mitochondrial dysfunction . 6th Conference of Asian Society for Mitochondrial Research and Medicine .2009 ;(0):PF-02

37. 2009 Lo MC,Lu CI,Cheng MH,Chen CD,KaoSH,Lee HM. Advanced glycation end products cause mitochondrial dysfunction due to mitochondrial damage, mitophage, and mitochondrial fragmentation. . 6th Conference of Asian Society for Mitochondrial Research and Medicine .2009 ;(0):OF-01

38. 2009 Liao TL,Wang YP,Wei YH,Kao SH,Tzeng CR. Mitochondrial estrogen receptor beta in modulation mitochondrial DNA transcription in endometriosis. . 6th Conference of Asian Society for Mitochondrial Research and Medicine .2009 ;(0):PMT-15

39. 2008 Kao SH,Lee YR,,Tzeng CR.. Osteopontin in the endometriosis . Asia Pacific Initiative on Reproduction (ASPIRE 2008), Singapore .2008

40. 2008 Kao SH,Lee YR,Tzeng CR. Osteopontin in the endometriosis . American Society for Reproductive Medicine 64th Annual Meeting , 2008 November 8-12, San Francisco, California. .2008 ;(1):A-185

41. 2008 Wu WH,Chang SP,Kao SH. Mitochondrial Function in Modulatation of Human Granulosa Cell Steroidogenesis and Female Fertility . American Society for Reproductive Medicine, 64th Annaul Meeting, 2008 Nov 8-12, San Francisco, California. .2008 ;(1):p23-p23

42. 2008 Chang LW,Wang RS,Liu CS,Lee HM,Kao SH. Induced mitochondrial dysfunction and apoptosis of rat glioma cells by C6 ceramide. . 5th Conference of Asian Society for Mitochondrial Research and Medicine (China, Tianjin). PA-02 .2008 ;(0):PA-02

43. 2008 Wu WH,Chang SP,Kao SH. Mitochondrial function in modulation of human granulosa cell steroidogenesis and female fertility . Fert Steril .2008 ;(90):S118

44. 2007 Liao TL,Kao SH,Wei YH,Wang YP,Lai TC,Tzeng CR. Mitochondrial Estrogen Receptor β in the Modulation of Mitochondrial DNA Transcription in Endometriosis. . 4th Conference of Asian Society for Mitochondrial Research and Medicine, (Seoul, Korea, Feb 2-3). .2007 ;(1):p-36

45. 2007 Lu CI,Lee YR,Lee HM,Hsieh RH,Kao SH. Induced Mitochondrial Dysfunction and Cell Death of Pancreaticβcells by Nε-(carboxymethyl) lysine. . 4th Conference of Asian Society for Mitochondrial Research and Medicine, (Seoul, Korea, Feb 2-3. .2007 ;(1):p20-p20

46. 2007 Chang LW,Wang YP,Kao SH. Induced Oxidative Stress and Apoptosis of C6 Glioma Cells by C6- Ceramide. . 4th Conference of Asian Society for Mitochondrial Research and Medicine, (Seoul, Korea, Feb 2-3). .2007 ;(1):p-22

47. 2007 Kao SH,,Liao TL,,Wei YH,,Wang YP,,Lai TC,,Tzeng CR.. Mitochondrial Estrogen Receptor β on Mitochondrial DNA Modulation in Endometriosis. . 2007 Annual Meeting of European Society of Human Reproduction and Embryology. (Lyon, France, 2007, July 1st-4th), Poster P484. .2007

48. 2007 Chen IC,,Kao SH,,Wu GJ,,Tzeng CR.. Enhancement of embryo implantation ability by LPA supplementation through GRS2 signaling pathway. . 2007 Annual Meeting of European Society of Human Reproduction and Embryology. (Lyon, France, 2007, July 1st-4th). Clinical Science Award .2007 ;(1):p545-p545

49. 2006 Huang TY,Li JM,Shun CT,Kao SH. A preliminary and pilot study about mitochondrial DNA deletion in Sudden Infant Death Syndrome: an endemic study in Taiwan. . The 58th Annual Meeting of the American Academy of Forensic Sciences (AAFS) February 20-25, 2006, in Seattle, WA .2006

50. 2004 Kao S.H.,Liao, T.L.,Lee, H.M.. Oxidative stress mediates TCDD Induced Oxidative Damages and hypoxia inducing factor-1α expression in Human Trophoblast Cells. . The 60th Annual Meeting of the American Society for Reproductive Medicine.( Philadelphia, Pennsylvania, October 16-20), P- 487. .2004

51. 2004 Kao SH,,Huang HC,,Tzeng, CR,,Liao, TL,,Wei, YH.. Oxidative stress induce endometriosis progression. . 2nd Conference of Asian Society for Mitochondrial Research and Medicine.(Taipei, April 1-2) .2004

52. 2004 Kao SH,,Liao TL,,Lee HM,,Tzeng, C.. TCDD-induced oxidative damages in human trophoblast cells. . 2nd Conference of Asian Society for Mitochondrial Research and Medicine, (Taipei, April 1-2) .2004

53. 2004 Kao, SH,,Hung, SL,,Chen, TH,,Lee HM. Celecoxib Induces Heme Oxygenase-1 Expression in Glomerular Mesangial Cells via c-Jun-N-terminal kinase and Phosphatidylinositol 3-kinase dependent pathways. . 2nd Conference of Asian Society for Mitochondrial Research and Medicine, (Taipei, April 1-2) .2004

54. 2004 Kao, SH,,Chen, HW,,Hwang, IS,,Chao, HT,,Liao, TL,,Wei, Y.. Oxidative stress status and mitochondrial DNA mutations on Sperm Declined Motility. . 2nd Conference of Asian Society for Mitochondrial Research and Medicine, (Taipei, April 1-2) .2004

55. 2004 Kao, SH,,Lee SY,,Liao, TL,,Chen, SC,,Chao, HT.. Repeated ovarian ovulations induce mitochondrial DNA mutations and oxidative damages in mouse ovaries and livers. . 2nd Conference of Asian Society for Mitochondrial Research and Medicine, (Taipei, April 1-2) .2004

56. 2004 Hiseh RH,,Li JY,,Kao SH,,Pang CY,,Wei YH.. Energy demand affected distribution of MELAS-associated mtDNA mutations in multiple tissues. . 2nd Conference of Asian Society for Mitochondrial Research and Medicine, (Taipei, April 1-2) .2004

57. 2004 Liao, T.L.,,Tzeng, C.R.,,Chen, Y.T.,,Lin, T.Y,Chao H. T.,,Kao, S.H.. Oxidative stress mediates TCDD-induced hypoxia and oxidative damages in human trophoblast cells. . The 4th Conference of the Pacific Rim Society for Fertility and Sterility. (Okinawas, Japan, March 8-11) .2004

58. 2004 Kao S.H.,,Liao, T.L.,,Lee, H.M.,,Tzeng. C.R.. Oxidative stress mediates TCDD Induced Oxidative Damages and hypoxia inducing factor-1α expression in Human Trophoblast Cells. . The 60th Annual Meeting of the American Society for Reproductive Medicine.( Philadelphia, Pennsylvania, October 16-20). .2004

59. 2002 Lee, S.Y.,,Liao, T.L.,,Hsu, T.Y.,,Chen, Y.F,Tzeng, C.R.,,Kao, S.H.. Repeated Ovarian Superovulations Induce Mitochondrial DNA Mutations and Oxidative Damages in Mouse Ovaries. . The 3rD Conference of The Pacific Rim Society for Fertility and Sterility. .2002

60. 2002 Huang, H.C.,,Liao, T.L.,,Lin, H.Y.,,Tsai, M.C,Chao, H.T.,,Tzeng, C., and Kao, S.H.. Oxidative Stress Induce Endometriosis Progression. . The 3rD Conference of The Pacific Rim Society for Fertility and Sterility. .2002

61. 1997 Wei YH, Lee CH, Lu CY, Pang CY, Kao SH.. Mitochondrial DNA mutation and oxidative stress in human ageing. . 12th Joint Annual Conference of Biomedical Sciences. .1997

62. 1996 Wei YH, Lee CH, Kao SH.. Mitochodnrial DNA deletions and lipid peroxidation in human ageing. . Proceedings of the 12th FAOBMB Congress .1996

63. 1996 Kao SH, Chao HT, Wei YH.. Mitochondrial DNA deletions associated with declined fertility and motility of human sperm. . Proceedings of the 7th FAOBMB Congress .1996

64. 1995 Wei YH, Kao SH, Lee CH.. Simultaneous increse of mitochondrial DNA deletions and lipid peroxidation in human ageing. . Proceedings of the 7th FAOBMB Congress .1995

65. 1995 Kao SH, Chao HT, Wei YH.. Mitochondrial DNA deletions associated with declined fertility and motility of human sperm. . 10th Joint Annual Conference of Biomedical Sciences. .1995

66. 1994 Wei YH, Lee CH, Pang CY, Yang JH, Kao SH.. Tandem duplications and deletions in mitochodnrial DNA are early molecular events of human ageing process. . 16th IUBMB Congress Satellite Meeting on .1994

67. 1993 Kao SH, Lee CH, Hsu HS, Wei YH.. Ageing-associated DNA deletions and lipid peroxidations in the mitochondrial DNA of human testis. . International Conference on Clinical Molecular Biology .1993

書籍 Book


1. 1996 Wei YH, Kao SH.. Mitochondrial DNA mutations and lipid peroxidation in human ageing. . Berdanier, C.D., ed., CRC press, Inc., Boca Raton, Florida .1996 ;(Ch.9):165-188

2. 1993 Lee SL, Kao SH, Wei YH.. Regulation of sperm functions by active components in the follicular fluid. . Wei, Y.H., Chen, S.C., and Su, J.C., eds, World Scientific Publishing Co., Singapore .1993

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