張瀞文(Chang, Ching-Wen) 助理教授

Email
changc11@tmu.edu.tw
現   職
代謝與肥胖科學研究所 助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立陽明大學口腔生物研究所 博士
2012/02~2015/11
國立宜蘭大學食品科學系 學士
2005/09~2009/06

本校學術經歷

任職單位與職稱[起迄時間]
代謝與肥胖科學研究所助理教授
2023/02/01~

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
美國國家衛生研究院博士後研究員
2018/01/22~2023/01/21

專長與研究領域

學門領域
學術專長
脂質代謝
脂質代謝
肝癌
肝癌
人類遺傳學
人類遺傳學
分子生物
分子生物

論文著作

清冊下載


1. 2023 Chang CW,Chen YS,Huang CH,Lin CH,Ng WV,Chu LJ, Trépo E, Zucman-Rossi J, Siao K, Maher JJ, Chiew MY, Chou CH, Huang HD, Teo WH, Lee IS, Lo JF, Wang XW . A genetic basis of mitochondrial DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma . Hepatology .2023

2. 2023 Hung MH,Chang CW,Wang KC,Chaisaingmongkol J,Ruchirawat M,Greten TF, Wang XW. Purine anabolism creates therapeutic vulnerability in hepatocellular carcinoma through m6A-mediated epitranscriptomic regulation . Hepatology .2023

3. 2023 Feng D,Xiang X,Guan Y,Guillot A,Lu H,Chang CW, He Y, Wang H, H Pan, Ju C, Colgan SP, Tacke F, Wang XW, Kunos G, Gao B. Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models . The Journal of Clinical Investigation .2023

4. 2023 Potential Hepatic Lipid Markers Associated with Nonalcoholic Steatohepatitis and Fibrosis in Morbid Obesity Patients . Journal of Clinical Medicine .2023

5. 2023 Wu HC,Hsieh YR,Wang W,Chang CW,Chang IW,Chen CL, Chang CC, Chang CH, Kao WY, Huang SY. Potential Hepatic Lipid Markers Associated with Nonalcoholic Steatohepatitis and Fibrosis in Morbid Obesity Patients . Journal of Clinical Medicine .2023

6. 2023 Huang PC,Chang CW,Lin YC,Chen CY,Chen TY,Chuang LT, Liu CJ, Huang CL, Li WC. Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis . International Journal of Molecular Sciences .2023

7. 2022 Ching-Wen Chang,Zhuang Wei,Stewart R. Durell,Lichun Ma,Marshonna Forgues,Xin Wei Wang. A compendium of co-regulated mitoribosomal proteins in pan-cancer uncovers collateral defective events in tumor malignancy . Iscience .2022

8. 2022 Ningning Liu,Ching Wen Chang,Clifford J Steer,Xin Wei Wang,Guisheng Song. MicroRNA-15a/16-1 prevents hepatocellular carcinoma by disrupting the communication between Kupffer cells and regulatory T cells . Gastroenterology .2022

9. 2021 Lichun Ma,Limin Wang,Subreen A Khatib,Ching-Wen Chang,Sophia Heinrich,Dana A DominguezMarshonna Forgues, Julián Candia, Maria O Hernandez, Michael Kelly, Yongmei Zhao, Bao Tran, Jonathan M Hernandez, Jeremy L Davis, David E Kleiner, Bradford J Wood, Tim F Greten, Xin Wei Wang. Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma . Journal of hepatology .2021

10. 2021 Man Hsin Hung, Joo Sang Lee,Chi Ma,Laurence P Diggs,Sophia Heinrich,Ching Wen Chang, Lichun Ma, Marshonna Forgues, Anuradha Budhu, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Eytan Ruppin, Tim F Greten, Xin Wei Wang. Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma . Nature Communications .2021

11. 2021 Kuan-Yang Chen,Yi-Hsiang Huang,Wan-Huai Teo,Ching-Wen Chang,Yu-Syuan Chen,Yi-Chen Yeh, Chieh-Ju Lee, Jeng-Fan Lo. Loss of Tid1/DNAJA3 co-chaperone promotes progression and recurrence of hepatocellular carcinoma after surgical resection: a novel model to stratify risk of recurrence . Cancers .2021

12. 2019 Zhuang Wei,Ching-Wen Chang,Van Luo,Beilei Bian,Xuewei Ding. Graph Embedding Method Based Genetical Trajectory Reveals Migration History Among East Asians . bioRxiv .2019

13. 2019 Tsai-Ying Chen,Yi-Ta Hsieh,Jian-Min Huang,Chung-Ji Liu,Lu-Te Chuang,Pei-Chun Huang, Tz-Yu Kuo, Hao-Yuan Chia, Chia-Yi Chou, Ching-Wen Chang, Yi-Fen Chen, Hsin-Ming Chen, Jeng-Fan Lo, Wan-Chun Li. Determination of pyruvate metabolic fates modulates head and neck tumorigenesis . Neoplasia .2019

14. 2019 Ching-Wen Chang,Jeng-Fan Lo,Xin Wei Wang. Roles of mitochondria in liver cancer stem cells . Differentiation .2019

15. 2018 Ching-Wen Chang, Yu-Syuan Chen,Yeou-Guang Tsay, Chia-Li Han,Yu-Ju Chen,Cheng-Chieh Yang, Kai-Feng Hung, Chao-Hsiung Lin, Tsung-Yen Huang, Shou-Yen Kao, Te-Chang Lee, Jeng-Fan Lo. ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells . Cell Death & Disease .2018

16. 2018 Yu-Syuan Chen,Ching-Wen Chang,Yeou-Guang Tsay,Liu-Ying Huang,Yi-Chen Wu,Li-Hao Cheng, Cheng-Chieh Yang, Cheng-Hsien Wu, Wan-Huai Teo, Kai-Feng Hung, Chih-Yang Huang, Te-Chang Lee. HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling . Theranostics .2018

17. 2016 Ching-Wen Chang,Yu-Syuan Chen,Chien-Chih Chen,Ik-On Chan,Chin-Chu Chen,Sen-Je Sheu, Ting-wei Lin, Shiu-Huey Chou, Chung-Ji Liu, Te-Chang Lee, Jeng-Fan Lo. Targeting cancer initiating cells by promoting cell differentiation and restoring chemosensitivity via dual inactivation of STAT3 and Src activity using an active component of Antrodia cinnamomea mycelia . Oncotarget .2016

18. 2014 Ching-Wen Chang,Yu-Syuan Chen,Shiu-Huey Chou,Chia-Li Han,Yu-Ju Chen,Cheng-Chieh Yang, Chih-Yang Huang, Jeng-Fan Lo. Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity . Cancer Research .2014

研究計畫

計畫名稱
113 Dnaja3-Tp53 雙缺失驅動具有性別差異的脂肪肝癌進展:機制見解和治療意義-延攬博後王人弘
補助單位
國家科學及技術委員會

計畫名稱
112 Dnaja3-Tp53 雙缺失驅動具有性別差異的脂肪肝癌進展:機制見解和治療意義
補助單位
國家科學及技術委員會

計畫名稱
111 新聘教師研究補助
補助單位
臺北醫學大學