| 1. |
2024
Hsu TI,Chen YP,Zhang RL,Chen ZA,Wu CH,Chang WC, Mou CY, Chan HW, Wu SH..
Overcoming the Blood-Brain Tumor Barrier with Docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma.
. ACS Appl Mater Interfaces
.2024
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| 2. |
2024
Sharma R,Chiang YH,Chen HC,Lin HY,Yang WB,Nepali K, Lai MJ, Chen KY, Liou JP*, Hsu TI*.
Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress
. Cancer Lett
.2024
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| 3. |
2024
Sharma S, ,Wang SA, ,Yang WB, ,Lin HY, ,Lai MJ, ,Chen HC, Kao TY, Hsu FL, Nepali K, Hsu TI*, Liou JP*.
First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo
. J Med Chem
.2024
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| 4. |
2024
Chen HC#,Hsu TI#,Chao TY,Yang ST*.
Neurocutaneous Melanosis with Meningeal Melanocytosis: A Rare Case of Intracranial Hypertension and Cutaneous Manifestations
. Life
.2024
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| 5. |
2023
Mitochondrial Mechanisms in Temozolomide Resistance: Unraveling the Complex Interplay and Therapeutic Strategies in Glioblastoma
. Mitochondrion
.2023
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| 6. |
2023
Li HY,Feng YH,Lin CL,Hsu TI*.
Mitochondrial Mechanisms in Temozolomide Resistance: Unraveling the Complex Interplay and Therapeutic Strategies in Glioblastoma
. Mitochondrion
.2023
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| 7. |
2023
Kao TJ,Lin CL,Yang WB,Li HY,Hsu TI.
Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities
. Lipids Health Dis
.2023
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| 8. |
2023
Chen HC,Chang WC,Chuang JY,Chang KY,Liou JP,Hsu TI*.
The complex role of eicosanoids in the brain: Implications for brain tumor development and therapeutic opportunities
. Biochim Biophys Acta Rev Cancer
.2023
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| 9. |
2023
Hsu TI.
Editorial: Metabolic reprogramming for acquiring therapeutic resistance in glioblastoma
. Front Oncol
.2023
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| 10. |
2022
Tsou YS,Wang CY,Chang MY,Hsu TI,Wu MT,Wu YH, Tsai WL, Chuang JY, Kao TJ.
Vav2 is required for Netrin-1 receptor-class-specific spinal motor axon guidance
. Developmental Dynamics
.2022
;(251):444-458
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| 11. |
2022
Tsai YT,Lo WL,Chen PY,Ko CY,Chuang JY,Kao TJ, Yang WB, Chang KY, Hung CY, Kikkawa U, Chang WC*, Hsu TI*.
Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation
. J Biomed Sci
.2022
;(29)
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| 12. |
2022
Feng YH#,Lim SW#,Lin HY,Wang SA,Hsu SP,Kao TJ, Ko CY*, Hsu TI*.
Allopregnanolone suppresses glioblastoma survival through decreasing DPYSL3 and S100A11 expression
. Journal of Steroid Biochemistry and Molecular Biology
.2022
;(219):106067-106067
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| 13. |
2022
Wu AC,Yang WB,Chang KY,Lee JS,Liou JP,Su RY, Cheng SM, Hwang DY, Kikkawa U, Hsu TI, Wang CY, Chang WC, Chen PY, Chuang JY.
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells
. Journal of Experimental & Clinical Cancer Research
.2022
;(41):47-47
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| 14. |
2021
Kao TJ,Wang CY,Hsu TI,Wu YH,Chuang JY,Huang CC, Hsieh CT.
TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb
. Neuroscience Research
.2021
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| 15. |
2021
Yang WB,Wu AC,Hsu TI,Liou JP,Lo WL,Chang KY, Chen PY, Kikkawa U, Yang ST, Kao TJ, Chen RM, Chang WC, Ko CY, Chuang JY.
Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells
. Cell Death & Disease
.2021
;(12):884-884
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| 16. |
2021
Tsai YT,Wu CC,Ko CY,Hsu TI,Chang WC,Lo WL, Chuang JY*.
Correlation between the expression of cancer stem cell marker BMI1 and glioma prognosis
. Biochem Biophys Res Commun
.2021
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| 17. |
2021
Tsai WL,Chang CJ,Hsu TI,Wu YH, Chang PS, Lin KL, Chuang JY, Kania A, Kao TJ*.
Paxillin is required for proper spinal motor axon growth into the limb
. J Neurosci
.2021
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| 18. |
2021
Nepali K,Hsu TI,Hsieh CM,Lo WL,Lai MJ,Hsu KC, Lin TE, Chuang JY, Liou JP*.
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma
. Eur J Med Chem
.2021
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| 19. |
2021
林宏益#,廖國興#,柯瓊媛,陳冠元,徐松柏,洪家揚, 徐宗溢*.
17beta-estradiol induces temozolomide resistance through NRF2-mediated redox homeostasis in glioblastoma
. Free Radic Biol Med
.2021
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| 20. |
2020
Chen TC,Chuang JY,Ko CY,Kao TJ,Yang PY,Yu CH, Liu MS, Hu SL, Tsai YT, Chan Hardy, Chang WC, Hsu TI.
AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis
. Redox Biol
.2020
;(30)
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| 21. |
2020
Lo WL,Hsu TI,Yang WB,Kao TJ,Wu MS,Huang YN, Yeh SH, Chuang JY.
Betulinic Acid-Mediated Tuning of PERK/CHOP Signaling by Sp1 Inhibition as a Novel Therapeutic Strategy for Glioblastoma
. Cancers
.2020
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| 22. |
2020
Yang WB,Hsu CC,Hsu TI,Liou JP,Chang KY,Chen PY, Liou JJ, Yang ST, Wang JY, Yeh SH, Chen RM, Chang WC, Chuang JY.
Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma
. Neuro-Oncology
.2020
|
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| 23. |
2020
Limanjaya I,Hsu TI,Chuang JY,Kao TJ*.
L-selectin activation regulates Rho GTPase activity via Ca+2 influx in Sertoli cell line, ASC-17D cells
. Biochem Biophys Res Commun
.2020
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| 24. |
2020
Hung CY,Hsu TI,Chuang JY,Su TP,Chang WC,Hung JJ*.
Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis
. Mol Neurobiol
.2020
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| 25. |
2019
Chien CH,Chuang JY,Yang ST,Yang WB,Chen PY,Hsu TI, Huang CY, Lo WL, Yang KY, Liu MS, Chu JM, Chung PH, Liu JJ, Chou SW, Chen SH, Chang KY*.
Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
. J Biomed Sci
.2019
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| 26. |
2019
Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ, Ko CY*.
CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation
. J Neuroinflammation
.2019
|
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| 27. |
2019
Tsai YT,Wu AC,Yang WB,Kao TJ,Chuang JY,Chang WC, Hsu TI.
ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade
. International Journal of Molecular Sciences
.2019
;(20)
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| 28. |
2019
Lin HY,Ko CY,Kao TJ,Yang WB,Tsai YT,Chuang JY, Hu SL, Yang PY, Lo WL, Hsu TI.
CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis
. Cancers
.2019
;(11)
|
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| 29. |
2018
Wang YC,Wu YS,Hung CY,Wang SA,Young MJ,Hsu TI, Hung JJ*.
USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
. Nat Commun
.2018
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| 30. |
2018
Yang WB,Chuang JY,Ko CY,Chang WC,Hsu TI.
Dehydroepiandrosterone Induces Temozolomide Resistance Through Modulating Phosphorylation and Acetylation of Sp1 in Glioblastoma
. Mol Neurobiol
.2018
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| 31. |
2017
Ko CY,Lin CH,Chuang JY,Chang WC,Hsu TI.
MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance
. Mol Neurobiol.
.2017
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| 32. |
2017
Chuang JY ,Lo WL,Ko CY ,Chou SY ,Chen RM ,Chang KY, Hung JJ, Su WC, Chang WC, Hsu TI.
Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma
. Oncogenesis
.2017
;(6):e339-e339
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| 33. |
2017
Chang KY ,Huang CT,Hsu TI,Hsu CC,Liu JJ,Chuang CK, Hung JJ, Chang WC, Tsai KK, Chuang JY..
Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma
. Biochem Biophys Res Commun
.2017
;(493):14-19
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| 34. |
2017
Chang KY,Hsu TI,Hsu CC,Tsai SY,Liu JJ,Chou SW, Liu MS, Liou JP, Ko CY, Chen KY, Hung JJ, Chang WC, Chuang CK, Kao TJ, Chuang JY..
Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase
. Redox Biology
.2017
;(13):655-664
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| 35. |
2016
Wang YC,Wang SA,Chen PH,Hsu TI,Chuang YP,Su WC, Liaw HJ, Chang WC, Hung JJ.
Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy
. Oncogene
.2016
|
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| 36. |
2016
Hsu TI,Wang YC,Hung CY,Yu CH,Su WC,Chang WC ,Hung JJ.
Positive feedback regulation between IL10 and EGFR promotes lung cancer formation
. Oncotarget
.2016
|
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| 37. |
2016
Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY, Liou JP, Ko CY, Chang KY, Chuang JY.
Suberoylanilide hydroxamic acid represses glioma stem-like cells
. J Biomed Sci.
.2016
;(23):81-92
|
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| 38. |
2015
Hsu TI,Chen YJ,Hung CY,Lin SJ,Su WC,Lai MD, Kim SY, Wang Q, Qian K, Goto M, Zhao Y, Kashiwada Y, Lee KS, Chang WC, Hung JJ.
A Novel Derivative of Betulinic Acid, SYK023, Suppresses Lung Cancer Growth and Malignancy
. Oncotarget
.2015
;(6):13671-13687
|
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| 39. |
2015
Hsu TI,Lin SC,Lu PS,Chang WC,Hung CY,Yeh YM, Su WC, Liao PC, Hung JJ.
MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy
. Oncogene
.2015
;(34):826-837
|
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| 40. |
2014
Hung CY,Yang WB,Wang SA,Hsu TI,Chang WC,Hung JJ.
Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis
. Biochim Biophys Acta
.2014
;(1843):2843-2854
|
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| 41. |
2014
Wang SA,Hung CY,Chuang JY,Chang WC,Hsu TI,Hung JJ.
Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression
. Biochim Biophys Acta
.2014
;(1843):1135-1149
|
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| 42. |
2014
Yang WB,Chen PH,Hsu TI,Fu TF,Su WC,Liaw H, Chang WC, Hung JJ.
Sp1-mediated microRNA-182 expression regulates lung cancer progression
. Oncotarget
.2014
;(5):740-753
|
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| 43. |
2014
Hsu CC,Chen CH,Hsu TI,Hung JJ,Ko JL,Zhang B, Lee YC, Chen HK, Chang WC, Lin DY.
The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF)
. Biochim Biophys Acta
.2014
;(1843):565-579
|
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| 44. |
2012
Hsu TI,Wang MC,Chen SY,Huang ST,Yeh YM,Su WC, Chang WC, Hung JJ.
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth
. Mol Pharmacol
.2012
;(82):1115-1128
|
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| 45. |
2012
Hsu TI,Wang MC,Chen SY,Yeh YM,Su WC,Chang WC, Hung JJ.
Sp1 expression regulates lung tumor progression
. Oncogene
.2012
;(31):3973-3988
|
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| 46. |
2011
Wang SA,Li HY,Hsu TI,Chen SH,Wu CJ,Chang WC, Hung JJ.
Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis
. J Biol Chem
.2011
;(286):43816-43829
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| 47. |
2011
Yeh SH,Yang WB,Gean PW,Hsu CY,Tseng JT,Su TP, Chang WC, Hung JJ.
Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway
. Nucleic Acids Res
.2011
;(39):5412-5423
|
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| 48. |
2010
Liu YW,Wang SA,Hsu TY,Chen TA,Chang WC,Hung JJ.
Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells
. J Cell Biochem
.2010
;(110):1430-1438
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