林秋烽(Lin, Chiou-Feng)　教授

Email
cflin2014@tmu.edu.tw
現   職
免疫監測核心實驗室 主任
微生物免疫學科 教授
醫學科學研究所 所長

學經歷

學　歷

畢業學校與學位[修業時間]
成功大學基礎醫學研究所 博士
1998/09~2002/06
成功大學微免所 碩士
1996/09~1998/06
中山醫學大學醫技系 學士
1992/09~1996/06

本校學術經歷

任職單位與職稱[起迄時間]
微生物免疫學科教授
2015/08/01~
微生物免疫學科副教授
2014/08/01~2015/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學科學研究所所長
2024/09/01 ~
國際轉譯科學博士學位學程教授
2023/05/01 ~
免疫監測核心實驗室主任
2019/02/20 ~
未聘任老師虛擬單位副研發長
2019/01/03 ~ 2022/07/31
非正式組織虛擬單位副研發長
2019/01/03 ~ 2022/07/31
研究發展處副研發長
2019/01/01 ~ 2022/07/31
醫學系副主任
2018/08/01 ~ 2018/12/31
(舊)細胞治療與再生醫學國際博士學位學程籌備處教授
2018/08/01 ~
微生物免疫學科主任
2017/08/01 ~ 2023/07/31

其它經歷

任職單位與職稱[起迄時間]
成功大學副教授
2010/08~2014/07
成功大學助理教授
2006/10~2010/07

專長與研究領域

學門領域
微生物及免疫學
學術專長
Protein Analysis
Biomarker Analysis
Immunostaining
Infectious Disease
Cell Death Assay
Cellular Response
Flow Cytometry
Animal Model

論文著作

清冊下載

論文 Journal Paper


1. 2024 Desmethylclomipramine triggers mitochondrial damage and death in TGF-β-induced mesenchymal type of A549 cells . Life Sci. .2024 ;(351):122817

2. 2024 Antiviral effects of Sarcodia suae water extracts against vesicular stomatitis virus infection . Eur J Phycol. .2024 ;(59):490-500

3. 2023 Persistent dysregulation of cellular immunity following COVID-19 recovery despite minimal post-COVID-19 sequelae manifestation . J. Infect. .2023

4. 2023 Anticancer polypyrrole-polyethylenimine drug-free nanozyme for precise B-cell lymphoma therapy . Biomed Pharmacother . .2023 ;(160):114397

5. 2023 Measurement of lipid droplets in peripheral immune cells shows an immunomodulatory effect on monocyte polarization in experimental dyslipidaemia . Biochem Biophys Res Commun . .2023 ;(650):73-80

6. 2023 Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model . Mol Ther Oncolytics. .2023 ;(28):104-117

7. 2023 Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication . PLoS Pathog. .2023

8. 2023 Efficacy and Safety of Bruton Tyrosine Kinase Inhibitor Monotherapy Compared with Combination Therapy for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Systematic Review and Meta-Analysis . Cancers (Basel) .2023 ;(15):1996

9. 2023 Polypeptide antibiotic actinomycin D induces Mcl-1 uncanonical downregulation in lung cancer cell apoptosis . Life Sci . .2023 ;(321):121615

10. 2023 Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model . Toxicol In Vitro. .2023

11. 2023 Efficacy and safety of add-on anti-CD20 monoclonal antibody to Bruton tyrosine kinase inhibitor treatment for chronic lymphocytic leukemia: a meta-analysis . Sci Rep. .2023 ;(13):9775

12. 2023 Efficacy and Safety of Bruton Tyrosine Kinase Inhibitor Plus Anti-CD20 Antibody Therapy Compared With Chemoimmunotherapy as Front-line Treatment for Chronic Lymphocytic Leukemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials . J Immunother. .2023 ;(46):299-309

13. 2023 Effectiveness and safety of CD22 and CD19 dual-targeting chimeric antigen receptor T-cell therapy in patients with relapsed or refractory B-cell malignancies: A meta-analysis . Cancer Med. .2023 ;(12):18767-18785

14. 2022 Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile . J Microbiol Immunol Infect . .2022

15. 2022 SHP2: the protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis . IUBMB Life .2022

16. 2022 Distinct B and NKT cell responses shape the delayed response to ChAdOx1 nCoV-19 vaccine in end-stage renal disease . J Infect. .2022

17. 2022 Elevated TNF-α Induces Thrombophagocytosis by Mononuclear Cells in ex vivo Whole-Blood Co-Culture with Dengue Virus . J Inflamm Res . .2022 ;(15):1717-1728

18. 2022 Epithelial-to-mesenchymal transition hinders interferon-γ-dependent immunosurveillance in lung cancer cells . Cancer Lett. .2022 ;(538):1-10

19. 2022 Role of Glycogen Synthase Kinase-3 in Interferon-γ-Mediated Immune Hepatitis . Int J Mol Sci. .2022

20. 2022 Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation . JCI Insight .2022

21. 2022 Monocyte Distribution Width in Children With Systemic Inflammatory Response: Retrospective Cohort Examining Association With Early Sepsis . Pediatr Crit Care Med . .2022 ;(23):698-707

22. 2022 Proteomic networks associated with tumor-educated macrophage polarization and cytotoxicity potentiated by heat-killed tuberculosis . Sci Rep. .2022 ;(12):6881

23. 2021 Repurposing the antiemetic metoclopramide as an antiviral against dengue virus infection in neuronal cells . Front. Cell. Infect. Microbiol. .2021

24. 2021 Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages . J Inflamm Res. .2021

25. 2021 Secretory autophagy participates in the trafficking of dengue virus proteins and full-length genome RNA through the autophagosome . Viruses .2021

26. 2021 Serum IL-18 is a potential biomarker for predicting severe dengue disease progression . J Immunol Res . .2021

27. 2021 IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis . Journal of Immunology Research .2021

28. 2021 Polarization of Type 1 Macrophages is Associated with the Se-verity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus . Cells .2021

29. 2021 Increased TNF- α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus . J Immunol Res . .2021

30. 2021 Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation . J Immunol Res . .2021

31. 2021 Profiles of Peripheral Immune Cells of Uncomplicated COVID-19 Cases with Distinct Viral RNA Shedding Periods . Viruses . .2021

32. 2021 Pharmacologically Inhibiting Glycogen Synthase Kinase-3β Ameliorates Renal Inflammation and Nephrotoxicity in an Animal Model of Cisplatin-Induced Acute Kidney Injury . Biomedicines .2021 ;(9):887

33. 2021 Monocyte Distribution Width, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio Improves Early Prediction for Sepsis at the Emergency Department . Journal of Personalized Medicine .2021 ;(11):732

34. 2021 Temporal Trends of Acute Kidney Injury and Associated Risk Exposures in Extremely Preterm Infants . Clin J Am Soc Nephrol . .2021 ;(16):1169-1177

35. 2021 Overcoming interferon (IFN)-γ resistance ameliorates transforming growth factor (TGF)-β-mediated lung fibroblast-to-myofibroblast transition and bleomycin-induced pulmonary fibrosis . Biochem Pharmacol. .2021

36. 2021 Lower risk of primary Sjogren's syndrome in patients with dengue virus infection: a nationwide cohort study in Taiwan . Clin Rheumatol. .2021

37. 2020 Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4 + T Lymphocytes . Cells .2020 ;(9):1424

38. 2020 CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain . Front Cell Infect Microbiol. .2020 ;(10):557610-557610

39. 2020 Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity . Front Cell Infect Microbiol . .2020 ;(10):375-375

40. 2019 Shen TJ,,Jhan MK,,Kao JC,,Ho MR,,Tsai TT,,Tseng PC, Wang YT, Lin CF*.. A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease. . J Vis Exp. .2019 ;(146)

41. 2019 Wu SY,,Chen CL,,Tseng PC,,Chiu CY,,Lin YE,,Lin CF*.. Fractionated ionizing radiation facilitates interferon-γ signaling and anticancer activity in lung adenocarcinoma cells. . J Cell Physiol. .2019

42. 2019 Krisnawati DI,,Liu YC,,Lee YJ,,Wang YT,,Chen CL,,Tseng PC, Lin CF*.. Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection. . Sci Rep. .2019 ;(9):5682-5862

43. 2019 Krisnawati DI,,Liu YC,,Lee YJ,,Wang YT,,Chen CL,,Tseng PC, Shen TJ, Lin CF*. Blockade Effects of Anti-interferon (IFN)-γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity. . J Immunol Res. .2019 ;(2019):1629258

44. 2019 Kuo CF,,Cheng MH,,Lin WC,,Lin CF*,,Lin YS,,Nina Tsao.. Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection . Sci Rep. .2019

45. 2018 Feng PH,Yu CT,Chen KY,Luo CS,Wu SM,Liu CY, Kuo LW, Chan YF, Chen TT, Chang CC, Lee CN, Chuang HC, Lin CF*, Han CL, Lee WH, Lee KY.. S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: the role of RELB . Oncotarget .2018 ;(9):7631-7643

46. 2018 Feng PH,Chen KY,Huang YC,Luo CS,Wu SM,Chen TT, Lee CN, Yeh CT, Chuang HC, Han CL, Lin CF*, Lee WH, Kuo CH, Lee KY.. Bevacizumab Reduces S100A9+ MDSC Linked to Intracranial Control in Patients with EGFR Mutant Lung Adenocarcinoma . J Thorac Oncol. .2018 ;(13):958-967

47. 2018 Jhan MK,HuangFu WC,Chen YF,Kao JC,Tsai TT,Ho MR, Shen TJ, Tseng PC, Wang YT, Lin CF*.. Anti-TNF-α restricts dengue virus-induced neuropathy. . J Leukoc Biol. .2018 ;(104):961-968

48. 2018 Kao JC,,HuangFu WC,,Tsai TT,,Ho MR,,Jhan MK,,Shen TJ, Tseng PC, Wang YT, Lin CF*.. The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR. . PLoS Negl Trop Dis. .2018 ;(12):e0006715-e0006715

49. 2018 Chiu WH,,Wu YW,,Lin CF*,,Lin YS,,Su WC.. Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells. . Cell Death Discovery .2018 ;(4):33

50. 2018 Jhan MK,,Shen TJ,,Tseng PC,,Wang YT,,Lin CF*.. Signaling of macrophage inflammatory protein (MIP)-3β facilitates dengue virus-induced microglial cell migration . Viruses. .2018 ;(10):690-700

51. 2017 Chen YD,Fang YT,Chang CP,Lin CF*,Hsu LJ,Wu SR, Chiu YC, Anderson R, Lin YS*. S100A10 regulates ULK1 localization to ER-mitochondria contact sites in IFN-γ-triggered autophagy . J Mol Biol .2017 ;(429):142-157

52. 2017 Lin CF*,Lin CM,Lee KY,Wu SY,Feng PH,Chen KY, Chuang HC, Chen CL, Wang YC, Tseng PC, Tsai TT. Escape from IFN-γ-dependent immunosurveillance in tumorigenesis . J Biomed Sci .2017 ;(24):10

53. 2017 Tai TW,Chen CY,Su FC,Tu YK,Tsai TT,Lin CF*, Chou IM*.. Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells. . Sci Rep. .2017 ;(7):44245

54. 2017 Jhan MK,Tsai TT,Chen CL,Tsai CC,Cheng YL,Lee YC, Ko CY, Lin YS, Chang CP, Lin LT, Lin CF*.. Dengue virus infection increases microglial cell migration. . Sci Rep. .2017 ;(7):91-103

55. 2017 Chen HH,Chen CC,Lin YS,Lin CF*,Chen CL,Chang PC, Chang CP*.. AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78. . Antivirus Res. .2017 ;(142):158-168

56. 2017 Ho MR,Tsai TT,Jhan MK,Chen CL,Lee YC,Chen CH, Lin CF*.. Blockade of dengue virus infection and viral cytotoxicity in neuronal cells by targeting endocytic pathways . Sci Rep. .2017 ;(7):6910-6921

57. 2017 King YA,Hu CH,Lee YJ,Lin CF*,Liu D,Wang KH*. Disseminated Cutaneous Mycobacterium kansasii Infection Presenting with Rosai-Dorfman disease-like histological features in a patient carrying anti-IFN-γ autoantibodies . J Dermatol. .2017

58. 2017 Chen YD,Fang YT,Cheng YL,Lin CF*,Hsu LJ,Wang SY, Anderson R, Chang CP*, Lin YS*.. Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-gamma-stimulated lung epithelial cells . Sci Rep. .2017 ;(7):5676

59. 2017 Cheng YL,Wu YW,Kuo CF,Lu SL,Liu FT,Anderson R, Lin CF*, Liu YL, Wang WY, Chen YD, Zheng PX, Wu JJ, Lin YS*.. Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus. . mBIO .2017 ;(8):899-917

60. 2017 Tsai TT,Chen CL,Tsai CC,Lin CF*.. Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo. . Antiviral Res. .2017 ;(145):44-53

61. 2017 Wan SW,Chen CY,Chen PW,Chou WH,Li CL,Chu YT, Chen YD, Liu YL, Anderson R, Lin CF*, Wang S, Chang CP, Yeh TM, Chen YH, Lin YS*.. Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection . J Immunol. .2017 ;(199):2834-2844

62. 2016 Tsai TT,Chen CL,Lin YS,Chang CP,Tsai CC,Cheng YL, Huang CC, Ho CJ, Lee YC, Lin LT, Jhan MK, Lin CF*. Microglia retard dengue virus-induced acute viral encephalitis . Sci Rep. .2016 ;(6):27670-27680

63. 2016 Cheng YL,Lin YS,Chen CL,Tsai TT,Tsai CC,Wu YW, Ou YD, Chu YY, Wang JM, Yu CY, Lin CF*.. Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes . Sci Rep. .2016 ;(6):32000-32015

64. 2016 Lin CF*,Chen CL,Chien SY,Tseng PC,Wang YC,Tsai TT.. Oxidative Stress Facilitates IFN-γ-Induced Mimic Extracellular Trap Cell Death in A549 Lung Epithelial Cancer Cells . PLoS One .2016 ;(11):162157

65. 2016 Lin CF*,Chien SY,Chen CL,Hsieh CY,TSeng PC,Wang YC.. IFN-γ Induces Mimic Extracellular Trap Cell Death in Lung Epithelial Cells through Autophagy-regulated DNA Damage. . J Interferon Cytokine Res .2016 ;(36):100-112

66. 2016 Wan SW,Yang YW,Lin CF*,Chang CP,Yeh TM,Anderson R, Lin YS*.. Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages. . Thromb. Haemost. .2016 ;(115):646-656

67. 2016 Huang SM,Liao WT,Lin CF*,Sun HS,Chow NH. Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves' Disease. . World J Surg. .2016 ;(40):505-509

68. 2016 Lin CF*,Tsai CC,Huang WC,Wang YC,Tseng PC,Tsai TT, Chen CL*.. Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis. . PLoS One .2016 ;(11):e01454

69. 2016 Tseng PC,Chen CL,Shan YS,Lin CF*. An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells. . Oncotarget .2016 ;(7):15150-15160

70. 2016 Klionsky DJ*,...Lin CF*.... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). . Autophagy .2016 ;(12):1-222

71. 2016 Chen CL,Wu YY,Lin CF*,Kuo CF,Han CL,Wang S, Chuang WJ, Chen CY, Wu JJ, Tsai PJ, Liu CC, Lin YS*. Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage . Sci Rep. .2016 ;(6):26026

72. 2015 Chen CL,Chiang TH,Tseng PC,Wang YC,Lin CF*.. Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ. . Biochemical and Biophysical Research Communications .2015 ;(466):578-584

73. 2015 Wang LC,Chen SO,Chiang SP,Yu CK,Lee YP,Tseng PC, Hsieh CY, Chen SH*, Lin CF*.. Enterovirus 71 Proteins 2A and 3D Antagonize the Antiviral Activity of Gamma Interferon via Signaling Attenuation. . J Virol. .2015 ;(89):7028-7037

74. 2015 Chiu WH,Su WC,Li CL,Chen CL*,Lin CF*. An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells. . Oncotarget .2015 ;(6):1-12

75. 2015 Hsing CH,Chen CL,Lin WC,Lin CF*. Propofol treatment inhibits constitutive apoptosis in primary neutrophils and granulocyte-differentiated HL60 cells. . PLOS ONE .2015 ;(10):e01296

76. 2015 Cheng YL,Lin YS,Chen CL,Wan SW,Ou YD,Yu CY, Tsai TT, Tseng PC, Lin CF*.. Dengue virus infection causes the activation of distinct NF-κB pathways for inducible nitric oxide synthase and TNF-α expression in RAW264.7 cells. . Mediators Inflamm. .2015 ;(2015):274025

77. 2015 Lin MC,Lin CF*,Li CF,Sun DP,Wang LY,Hsing CH*.. Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production. . Int J Med Sci. .2015 ;(16):12092-12107

78. 2015 Lin WC*,Chen CW,Huang YW,Chao L,Chao J,Lin YS, Lin CF*.. Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. . Scientific Reports .2015 ;(5):12463

79. 2015 Cheng HJ,Luo YH,Wan SW,Lin CF,Wang ST,Hung NT, Liu CC, Ho TS, Liu HS, Yeh TM, Lin YS*. Correlation of serum levels between anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients. . Am J Trop Med Hyg. .2015 ;(92):989-995

80. 2015 Hsieh CY,Chen CL,Yang KC,Ma CT,Choi PC,Lin CF*. Detection of reactive oxygen species during the cell cycle under normal culture conditions using a modified fixed-sample staining method. . J Immunoassay Immunochem. .2015 ;(36):149-161

81. 2014 Yen CL,Chao WC,Wu CH,Huang YF,Chang CS,Tsai YS, Lin CF, Shieh CC*. Phosphorylation of glycogen synthase kinase-3β in metabolically abnormal obesity affects immune stimulation-induced cytokine production . Int J Obes (Lond). .2014

82. 2014 Lin CF,Young KC,Bai CH,Yu BC,Ma CT,Chien YC, Chiang CL, Liao CS, Lai HW, Tsao CW*. Rosiglitazone regulates anti-inflammation and growth inhibition via PTEN . J Biomed Biotechnol. .2014 ;(2014):787924

83. 2014 Wan SW,Lu YT,Huang CH,Lin CF,Anderson R,Liu HS, Yeh TM, Yen YT, Wu-Hsieh BA, Lin YS*. Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1 . PLoS One. .2014 ;(9):e92495

84. 2014 Tseng PC,Chen CL,Shen YS,Chang WT,Liu HS,Hong TM, Hsieh CY, Lin SH, Lin CF*.. An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2. . Cell Communication and Signaling. .2014 ;(12):69

85. 2014 Tsai TT,Chuang YJ,Lin YS,Chang CP,Wan SW,Lin SH, Chen CL, Lin CF*.. Antibody-Dependent Enhancement Infection Facilitates Dengue Virus-Regulated Signaling of IL-10 Production in Monocytes. . PLoS Neglected Tropical Diseases. .2014 ;(8):e3320

86. 2014 Fang YT,Wan SW,Lu YT,Yao JH,Lin CF,Brown MG, Marshall JS, Anderson R*, Lin YS*.. Autophagy Facilitates Antibody-Enhanced Dengue Virus Infection in Human Pre-Basophil/Mast Cells . PLoS One .2014 ;(9):110655

87. 2014 Wang YC,Chen CL,Sheu BS,Yang YJ,Tseng PC,Hsieh CY, Lin CF*. Helicobacter pylori Infection Activates Src Homology-2 Domain-Containing Phosphatase 2 to Suppress IFN-γ Signaling. . J Immunol. .2014 ;(193):4149-4158

88. 2014 Hsieh CY,Chen CL,Lin YS,Yeh TM,Tsai TT,Hong MY, Lin CF*. Macrophage Migration Inhibitory Factor Triggers Chemotaxis of CD74+CXCR2+ NKT Cells in Chemically Induced IFN-γ-Mediated Skin Inflammation. . J Immunol. .2014 ;(193):3693-3703

89. 2014 Tai TW,Chen CY,Jou IM,Lin CF*. Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors . Bone .2014 ;(67):166-174

90. 2014 Chiu WC,Chen HHW,Chang JY,Luo SJ,Li CL,Su WC, Lin CF*. Inhibiting glycosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells . Cancer Lett. .2014 ;(349):144-151

91. 2014 Wang CY,Yang TT,Chen CL,Lin WC,Lin CF*. Reactive oxygen species generation facilitates glycogen synthase kinase-3β activation to mediate apoptosis in granulocyte-differentiated monocytes . Biochem Pharmacol. .2014 ;(88):86-94

92. 2014 Wang CY,Chiang TH,Chen CL,Tseng PC,Chien SY,Chuang YJ, Yang TT, Hsieh CY, Choi PC, Lin CF*. Autophagy facilitates cytokine-induced ICAM-1 expression . Innate Immun. .2014 ;(20):200-213

93. 2014 Chi CY,Lin CC,Liao IC,Yao YC,Liu CC,Lin CF*. Panton-Valentine Leukocidin facilitates the escape of Staphylococcus aureus from human keratinocyte endomsomes and induces apoptosis . J Infect Dis. .2014 ;(209):224-235

94. 2014 Wang CY,Lin CF*. Annexin A2: its molecular regulation and cellular expression in cancer development . Dis Markers. .2014 ;(2014):308976

95. 2013 Lin CF,Young KC,Bai CH,Ma CT,Chien YC,Su HC, Wang HY, Liao CS, Lai HW, Tsao CW*. Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW 264.7 cells . Immunopharmacol Immunotoxicol. .2013 ;(35):669-677

96. 2013 Jou IM,Lin CF,Tsai KJ,Wei SJ. Macrophage-Mediated Inflammatory Disorders . Mediators Inflamm. .2013 ;(2013):316482

97. 2013 Chen CL,Lin CF,Wan SW,Wei LS,Chen MC,Yeh TM, Liu HS, Anderson R, Lin YS*. Anti-Dengue Virus Nonstructural Protein 1 Antibodies Cause NO-Mediated Endothelial Cell Apoptosis via Ceramide-Regulated Glycogen Synthase Kinase-3β and NF-κB Activation . J Immunol. .2013 ;(191):1744-1752

98. 2013 Wan SW,Lin CF,Wang S,Chen YH,Yeh TM,Liu HS, Anderson R, Lin YS*. Current progress in dengue vaccines . J Biomed Sci. .2013 ;(20):37

99. 2013 Chang YT,Chen CL,Lin CF,Lu SL,Cheng MH,Kuo CF, Lin YS*. Regulatory role of GSK-3 β on NF- κ B, nitric oxide, and TNF- α in group A streptococcal infection . Mediators Inflamm. .2013 ;(2013):720689

100. 2013 Lin WC*,Lu SL,Lin CF,Chen CW,Chao L,Chao J, Lin YS. Plasma kallistatin levels in patients with severe community-acquired pneumonia . Crit Care .2013 ;(17):R27

101. 2013 Wan SW,Lin CF,Yeh TM,Liu CC,Liu HS,Wang S, Ling P, Anderson R, Lei HY, Lin YS*. Autoimmunity in dengue pathogenesis . J Formos Med Assoc. .2013 ;(112):3-11

102. 2013 Tsai TT,Chuang YJ,Lin YS,Wan SW,Chen CL,Lin CF*. An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection . J Biomed Sci. .2013 ;(20):37

103. 2013 Hong MY,Tseng CC,Chuang CC,Chen CL,Lin YH,Hsieh CY, Chang YT, Hsing CH, Chang KY, Lin CF*. Uropathogenic Escherichia coli causes cortical tubular necrotic cell death and the release of macrophage migration inhibitory factor . Cytokine .2013 ;(61):945-952

104. 2013 Yang TT,Chen CL,Lin WC,Lin YS,Tseng PC,Hsieh CY, Chen YH, Huang WC, Tsai CC, Wang CY, Shieh CC, Lin CF*. Glycogen synthase kinase-3β inactivation is an intracellular marker and regulator for endotoxemic neutrophilia . J Mol Med (Berl). .2013 ;(91):207-217

105. 2013 Shen WJ,Hsieh CY,Chen CL,Yang KC,Ma CT,Choi PC, Lin CF*. A modified fixed staining method for the simultaneous measurement of reactive oxygen species and oxidative responses . Biochem Biophys Res Commun. .2013 ;(430):442-447

106. 2012 Hong MY,Tseng CC,Chuang CC,Chen CL,Lin SH,Lin CF*. Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis . Mediators Inflamm. .2012 ;(2012):381358

107. 2012 Lin MC,Chen CL,Yang TT,Choi PC,Hsing CH,Lin CF*. Anesthetic propofol overdose causes endothelial cytotoxicity in vitro and endothelial barrier dysfunction in vivo . Toxicol Appl Pharmacol. .2012 ;(265):253-262

108. 2012 Liu SY#,Chen CL#,Yang TT,Huang WC,Hsieh CY,Shen WJ, Tsai TT, Shieh CC, Lin CF*. Albumin prevents reactive oxygen species-induced mitochondrial damage, autophagy, and apoptosis during serum starvation . Apoptosis .2012 ;(17):1156-1169

109. 2012 Hsieh CY,Chen CL,Tsai CC,Huang WC,Tseng PC,Lin YS, Chen SH, Wong TW, Choi PC, Lin CF*. Inhibiting Glycogen Synthase Kinase-3 Decreases 12-O-Tetradecanoylphorbol-13-Acetate-Induced Interferon-γ-Mediated Skin Inflammation . J Pharmacol Exp Ther. .2012 ;(343):125-133

110. 2012 Wang CY,Chen CL,Tseng YL,Fang YT,Lin YS,Su WC, Chen CC, Chang KC, Wang YC, Lin CF*. Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms . J Biol Chem. .2012 ;(287):32512-32524

111. 2012 Tseng PC,Huang WC,Chen CL,Sheu BS,Shan YS,Tsai CC, Wang CY, Chen SO, Hsieh CY, Lin CF*. Regulation of SHP2 by PTEN/AKT/GSK-3β signaling facilitates IFN-γ resistance in hyperproliferating gastric cancer . Immunobiology .2012 ;(217):926-934

112. 2012 Chiu WH,Luo SJ,Chen CL,Cheng JH,Hsieh CY,Wang CY, Huang WC, Su WC, Lin CF*. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells . Biochem Pharmacol. .2012 ;(83):1159-1171

113. 2012 Hsing CH,Chen YH,Chen CL,Huang WC,Lin MC,Tseng PC, Wang CY, Tsai CC, Choi PC, Lin CF*. Anesthetic propofol causes glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages . Anesthesiology .2012 ;(116):868-881

114. 2012 Hsing CH,Lin CF,So E,Sun DP,Chen TC,Li CF, Yeh CH*. α2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5 . Am J Physiol Renal Physiol. .2012 ;(303):F1443-F1453

115. 2012 Klionsky DJ,Abdalla FC,Abeliovich H,Abraham RT,Acevedo-Arozena A,Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, et al. Guidelines for the use and interpretation of assays for monitoring autophagy . Autophagy .2012 ;(8):445-544

116. 2012 Su HC,Ma CT,Yu BC,Chien YC,Tsai CC,Huang WC, Lin CF, Chuang YH, Young KC, Wang JN, Tsao CW*. Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine . Int Immunopharmacol. .2012 ;(14):150-156

117. 2012 Fang YT,Lin CF,Wang CY,Anderson R,Lin YS*. Interferon-γ stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis . J Cell Physiol. .2012 ;(227):2775-2787

118. 2012 Tsao CW*,Lin CF,Wu HT,Ma CT,Huang WC,Hsieh CY, Choi PC, Young KC. Glycogen synthase kinase-3β is critical for interferon-α-induced serotonin uptake in human Jurkat T cells . J Cell Physiol. .2012 ;(227):2556-2566

119. 2012 Wan SW,Lin CF,Lu YT,Lei HY,Anderson R,Lin YS*. Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection . J Cell Biochem. .2012 ;(113):1681-1691

120. 2011 Su HC,Ma CT,Lin CF,Wu HT,Chuang YH,Chen LJ, Tsao CW*. The acid sphingomyelinase inhibitors block interferon-α-induced serotonin uptake via a COX-2/Akt/ERK/STAT-dependent pathway in T cells . Int Immunopharmacol. .2011 ;(11):1823-1831

121. 2011 Lin WC,Lin CF,Chen CL,Chen CW,Lin YS*. Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury . J Pharmacol Exp Ther. .2011 ;(339):45-53

122. 2011 Chang YS,Lin CF,Wu CL,Kuo PY,Wu FS,Shieh CC, Gean PW, Chen ST, Chen MS, Wu WC, Tai MH, Tseng SH*. Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells . Invest Ophthalmol Vis Sci. .2011 ;(52):4214-4222

123. 2011 Lin YS*,Yeh TM,Lin CF,Wan SW,Chuang YC,Hsu TK, Liu HS, Liu CC, Anderson R, Lei HY. Molecular mimicry between virus and host and its implications for dengue disease pathogenesis . Exp Biol Med (Maywood). .2011 ;(236):515-523

124. 2011 Li MH,Luo YH,Lin CF,Chang YT,Lu SL,Kuo CF, Hong JS, Lin YS*. Dextromethorphan efficiently increases bactericidal activity, attenuates inflammatory responses, and prevents group a streptococcal sepsis . Antimicrob Agents Chemother. .2011 ;(55):967-973

125. 2011 Chang YS,Tsai CT,Huangfu CA,Huang WY,Lei HY,Lin CF, Su IJ, Chang WT, Wu PH, Chen YT, Hung JH, Young KC, Lai MD*. ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells . J Cell Biochem. .2011 ;(112):881-893

126. 2011 Ye YL#,Wu HT#,Lin CF#,Hsieh CY,Wang JY,Liu FH, Ma CT, Bei CH, Cheng YL, Chen CC, Chiang BL, Tsao CW*. Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway . Am J Physiol Lung Cell Mol Physiol. .2011 ;(300):L216-L224

127. 2011 Huang WC,Tsai CC,Chen CL,Chen TY,Chen YP,Lin YS, Lu PJ, Lin CM, Wang SH, Tsao CW, Wang CY, Cheng YL, Hsieh CY, Tseng PC, Lin CF*. Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis . FASEB J. .2011 ;(25):3661-3673

128. 2011 Tsai CC,Huang WC,Chen CL,Hsieh CY,Lin YS,Chen SH, Yang KC, Lin CF*. Glycogen synthase kinase-3 facilitates con a-induced IFN-γ-mediated immune hepatic injury . J Immunol. .2011 ;(187):3867-3877

129. 2011 Cheng YL,Huang WC,Chen CL,Tsai CC,Wang CY,Chiu WH, Chen YL, Lin YS, Chang CF*, Lin CF*. Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli . Biochem Biophys Res Commun. .2011 ;(412):334-340

130. 2011 Chang YP,Chen CL,Chen SO,Lin YS,Tsai CC,Huang WC, Wang CY, Hsieh CY, Choi PC, Lin CF*. Autophagy facilitates an IFN-γ response and signal transduction . Microbes Infect. .2011 ;(13):888-894

131. 2011 Hsing CH,Lin MC,Choi PC,Huang WC,Kai JI,Tsai CC, Cheng YL, Hsieh CY, Wang CY, Chang YP, Chen YH, Chen CL, Lin CF*. Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling . PLoS One .2011 ;(6):e17598

132. 2011 Huang WC,Chen CL,Lin YS,Lin CF*. Apoptotic sphingolipid ceramide in cancer therapy . J Lipids .2011 ;(2011):565316

133. 2010 Kai JI,Huang WC,Tsai CC,Chang WT,Chen CL,Lin CF*. Glycogen synthase kinase-3β indirectly facilitates interferon-γ-induced nuclear factor-κB activation and nitric oxide biosynthesis . J Cell Biochem. .2010 ;(111):1522-1530

134. 2010 Chuang CC,Chuang YC,Chang WT,Chen CC,Hor LI,Huang AM, Choi PC, Wang CY, Tseng PC, Lin CF*. Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection . BMC Immunol. .2010 ;(11):50

135. 2010 Chang YP,Tsai CC,Huang WC,Wang CY,Chen CL,Lin YS, Kai JI, Hsieh CY, Cheng YL, Choi PC, Chen SH, Chang SP, Liu HS, Lin CF*. Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation . J Biol Chem. .2010 ;(285):28715-28722

136. 2010 Tseng YL,Wu MH,Yang HC,Wang CY,Lin CF*. Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells . Cytokine .2010 ;(51):195-201

137. 2010 Lin CF*,Chen CL,Huang WC,Cheng YL,Hsieh CY,Wang CY, Hong MY. Different types of cell death induced by enterotoxins . Toxins (Basel) .2010 ;(2):2158-2176

138. 2010 Lin CY,Chang YC,Wang ST,Lee TY,Lin CF,Huang CC*. Altered inflammatory responses in preterm children with cerebral palsy . Ann Neurol. .2010 ;(68):204-212

139. 2010 Fang YT,Lin CF,Liao PC,Kuo YM,Wang S,Yeh TM, Shieh CC, Su IJ, Lei HY, Lin YS*. Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies . Mol Immunol. .2010 ;(47):1000-1009

140. 2010 Lin WC,Lin CF,Chen CL,Chen CW,Lin YS*. Prediction of outcome in patients with acute respiratory distress syndrome by bronchoalveolar lavage inflammatory mediators . Exp Biol Med (Maywood). .2010 ;(235):57-65

141. 2009 Cheng HJ,Lei HY,Lin CF,Luo YH,Wan SW,Liu HS, Yeh TM, Lin YS*. Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation . Mol Immunol. .2009 ;(47):398-406

142. 2009 Chen MC,Lin CF,Lei HY,Lin SC,Liu HS,Yeh TM, Anderson R, Lin YS*. Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency . J Immunol. .2009 ;(183):1797-1803

143. 2009 Cheng HJ,Lin CF,Lei HY,Liu HS,Yeh TM,Luo YH, Lin YS*. Proteomic analysis of endothelial cell autoantigens recognized by anti-dengue virus nonstructural protein 1 antibodies . Exp Biol Med (Maywood). .2009 ;(234):63-73

144. 2009 Huang WC,Lin YS,Wang CY,Tsai CC,Tseng HC,Chen CL, Lu PJ, Chen PS, Qian L, Hong JS, Lin CF*. Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells . Immunology .2009 ;(128):e275-e286

145. 2009 Wang CY,Lin YS,Su WC,Chen CL,Lin CF*. Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis . Mol Biol Cell. .2009 ;(20):4153-4161

146. 2009 Cheng YL,Wang CY,Huang WC,Tsai CC,Chen CL,Shen CF, Chi CY, Lin CF*. Staphylococcus aureus induces microglial inflammation via a glycogen synthase kinase 3beta-regulated pathway . Infect Immun. .2009 ;(77):4002-4008

147. 2009 Tsai CC,Kai JI,Huang WC,Wang CY,Wang Y,Chen CL, Fang YT, Lin YS, Anderson R, Chen SH, Tsao CW, Lin CF*. Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2 . J Immunol. .2009 ;(183):856-864

148. 2009 Wang Y,Huang WC,Wang CY,Tsai CC,Chen CL,Chang YT, Kai JI, Lin CF*. Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis . Br J Pharmacol. .2009 ;(157):1004-1013

149. 2009 Huang WC,Lin YS,Chen CL,Wang CY,Chiu WH,Lin CF*. Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia . J Pharmacol Exp Ther. .2009 ;(329):524-531

150. 2008 Lin CF,Wan SW,Chen MC,Lin SC,Cheng CC,Chiu SC, Hsiao YL, Lei HY, Liu HS, Yeh TM, Lin YS*.. Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model. . Lab Invest. .2008 ;(88):1079-1089

151. 2008 Lin CF*,Tsai CC,Huang WC,Wang CY,Tseng HC,Wang Y, Kai JI, Wang SW, Cheng YL.. IFN-gamma synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10. . J Cell Biochem. .2008 ;(105):746-755

152. 2008 Chen CL,Lin CF,Chang WT,Huang WC,Teng CF,Lin YS*.. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. . Blood. .2008 ;(111):4365-4374

153. 2008 Tsao CW*,Lin YS,Cheng JT,Lin CF,Wu HT,Wu SR, Tsai WH.. Interferon-alpha-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. . J Psychopharmacol. .2008 ;(22):753-760

154. 2008 Wan SW,Lin CF,Lin YS*.. C-terminal region of dengue virus nonstructural protein 1 is involved in endothelial cell cross-reactivity via molecular mimicry. . Am J Infect Dis. .2008 ;(4):85-91

155. 2008 Nguyen TH,Lan NT,Lin YS,Lin CF,Lien LB,Huang KJ, Yeh TM, Ha DQ, Huong VTQ, Chen LC, My LT, Huang JH, Liu CC, Lei HY*.. Anti-platelet and anti-endothelial cell autoantibodies in Vietnamese infants and children with dengue hemorrhagic fever. . Am J Infect Dis. .2008 ;(4):41-49

156. 2008 Lin CF*,Liu CC,Lei HY,Lin YS*. Patient and mouse antibodies against dengue virus nonstructural protein 1 cross-react with human platelets and cause their dysfunction. . Am J Infect Dis. .2008 ;(4):69-74

157. 2007 Luo YH,Kuo CF,Huang KJ,Wu JJ,Lei HY,Lin MT, Chuang WJ, Liu CC, Lin CF, Lin YS*.. Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis. . Kidney Int. .2007 ;(72):716-724

158. 2007 Lin CF*,Chen CL,Chiang CW,Jan MS,Huang WC,Lin YS*.. GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. . J Cell Sci. .2007 ;(120):2935-2943

159. 2007 Kuo CF,Chen CC,Lin CF*,Jan MS,Huang RY,Luo YH, Chuang WJ, Sheu CC, Lin YS*.. Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines. . Food Chem Toxicol. .2007 ;(45):278-285

160. 2007 Lin CF*,Wan SW,Lei HY,Lin YS*. Increased dengue virus-infected endothelial cell apoptosis caused by antibodies against nonstructural protein 1. . Dengue Bull. .2007 ;(31):111-117

161. 2006 Lin CF*,Wan SW,Cheng HJ,Lei HY,Lin YS*. Autoimmune pathogenesis in dengue virus infection. . Viral Immunol. .2006 ;(19):127-132

162. 2006 Qian L,Block ML,Wei SJ,Lin CF*,Reece J,Pang H, Wilson B, Hong JS, Flood PM*.. Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase. . J Pharmacol Exp Ther. .2006 ;(319):44-52

163. 2006 Lin CF*,Chen CL,Lin YS*. Ceramide in apoptotic signaling and anticancer therapy. . Curr Med Chem. .2006 ;(13):1609-1616

164. 2006 Chen CL,Lin CF*,Chiang CW,Jan MS,Lin YS*. Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis. . Mol Pharmacol. .2006 ;(70):510-517

165. 2006 Nguyen TH*,Nguyen TL,Lei HY,Lin YS,Le BL,Huang KJ, Lin CF, Do QH, Vu TQ, Lam TM, Yeh TM, Huang JH, Liu CC, Halstead SB.. Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. . Am J Trop Med Hyg. .2006 ;(74):684-691

166. 2005 Lin YS*,Lin CF*,Fang YT,Kuo YM,Liao PC,Yeh TM, Hwa KY, Shieh CC, Yen JH, Wang HJ, Su IJ, Lei HY.. Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity. . Clin Exp Immunol. .2005 ;(141):500-508

167. 2005 Nguyen TH*,Nguyen TL,Lei HY,Lin YS,Le BL,Huang KJ, Lin CF, Do QH, Vu TQ, Lam TM, Yeh TM, Huang JH, Liu CC, Halstead SB.. Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. . Am J Trop Med Hyg. .2005 ;(72):370-374

168. 2005 Lin CF*,Chen CL,Chang WT,Jan MS,Hsu LJ,Wu RH, Fang YT, Tang MJ, Chang WC, Lin YS*.. Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. . J Biol Chem. .2005 ;(280):23758-23765

169. 2005 Lin CF*,Chiu SC,Hsiao YL,Wan SW,Lei HY,Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, Lin YS*.. Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. . J Immunol. .2005 ;(174):395-403

170. 2004 Lin CF*,Chen CL,Chang WT,Jan MS,Hsu LJ,Wu RH, Tang MJ, Chang WC, Lin YS*.. Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis. . J Biol Chem. .2004 ;(279):40755-40761

171. 2004 Lin YS*,Lin CF*,Lei HY,Liu HS,Yeh TM,Chen SH, Liu CC.. Antibody-mediated endothelial cell damage via nitric oxide. . Curr Pharm Des. .2004 ;(10):213-221

172. 2004 Nguyen TH*,Lei HY,Nguyen TL,Lin YS,Huang KJ,Le BL, Lin CF, Yeh TM, Do QH, Vu TQ, Chen LC, Huang JH, Lam TM, Liu CC, Halstead SB.. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. . J Infect Dis. .2004 ;(189):221-232

173. 2004 Lin CF*,Lei HY,Liu CC,Liu HS,Yeh TM,Chen SH, Lin YS*.. Autoimmunity in dengue virus infection. . Dengue Bull. .2004 ;(28):51-57

174. 2003 Lin CF*,Lei HY,Shiau AL,Liu CC,Liu HS,Yeh TM, Chen SH, Lin YS*.. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. . J Med Virol. .2003 ;(69):82-90

175. 2002 Lin CF*,Lei HY,Shiau AL,Liu HS,Yeh TM,Chen SH, Liu CC, Chiu SC, Lin YS*.. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. . J Immunol. .2002 ;(169):657-664

176. 2001 Lin CF*,Lei HY,Liu CC,Liu HS,Yeh TM,Wang ST, Yang TI, Sheu FC, Kuo CF, Lin YS*.. Generation of IgM anti-platelet autoantibody in dengue patients. . J Med Virol. .2001 ;(63):143-149

177. 1999 Lin YS*,Huang YT,Chen PS,Lin CF*,Jan MS,Lei HY. Requirement of I-E molecule for thymocyte apoptosis induced by staphylococcal enterotoxin B in vivo. . Cell Immunol. .1999 ;(193):71-79

研究計畫

計畫名稱
113 靶向性幹細胞外泌體藥物於醫療未滿足嚴重肝臟疾病之精準治療策略:標靶急性肝衰竭與雷沙瓦抗藥性肝癌治療之藥物動力學/效力學及其免疫體學圖譜－探索CAR MSC外泌體改善急性肝衰竭及雷沙瓦抗藥性肝細胞癌的免疫恆定(1/3)
補助單位
國家科學及技術委員會
計畫名稱
113 糖尿病合併血脂異常增益登革病毒感染致病機制
補助單位
國家科學及技術委員會
計畫名稱
113 延攬詹茗凱君參與「靶向性幹細胞外泌體藥物於醫療未滿足嚴重肝臟疾病之精準治療策略:標靶急性肝衰竭與雷沙瓦抗藥性肝癌治療之藥物動力學/效力學及其免疫體學圖譜-探索CAR MSC外泌體改善急性肝衰竭及雷沙瓦抗藥性肝細胞癌的免疫恆定( 1/3)」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助 (NSTC 113-2811-B-038-049)
補助單位
國家科學及技術委員會
計畫名稱
113 「補助國內研究生出席國際學術會議」申請費用補助案(研究生：醫學科學研究所博士班洪于蘋君)
補助單位
國家科學及技術委員會
計畫名稱
112 麻醉劑異丙酚過量誘導輸液症候群模式造成血液毒性和免疫細胞炎性活化
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
112 高血糖症加劇登革病毒感染症的影響與機制(3/3)
補助單位
國家科學及技術委員會
計畫名稱
112 延攬詹茗凱君參與「高血糖症加劇登革病毒感染症的影響與機制」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助(NSTC 112-2811-B-038-029)
補助單位
國家科學及技術委員會
計畫名稱
111 麻醉劑異丙酚過量誘導輸液症候群模式造成血液毒性和免疫細胞異常的影響
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
111 開發周邊單核血球幹細胞檢測法研究計畫
補助單位
新研國際生化科技股份有限公司
計畫名稱
111 Predicting Post Dengue of ADE Risk and Immunity
補助單位
美商默沙東藥廠股份有限公司台灣分公司
計畫名稱
111 高血糖症加劇登革病毒感染症的影響與機制(2/3)
補助單位
國家科學及技術委員會
計畫名稱
111 (微生物及免疫學科林秋烽教授)延攬詹茗凱君參與「高血糖症加劇登革病毒感染症的影響與機制」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助(NSTC 111-2811-B-038-045)
補助單位
國家科學及技術委員會
計畫名稱
111 「補助國內研究生出席國際學術會議」申請費用補助案(研究生：國際醫學研究博士學位學程NGUYEN THI THUY君)
補助單位
國家科學及技術委員會
計畫名稱
111 蘇氏海木耳水萃物的抗病毒研究與應用：細胞模式與動物模式
補助單位
臺北醫學大學
計畫名稱
110 周邊血液免疫分析過量異丙酚誘導血液學毒性及其對血脂異常的細胞病理影響
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
110 高血糖症加劇登革病毒感染症的影響與機制(1/3)
補助單位
科技部
計畫名稱
110 科研創業計畫：監測血液免疫相合併智能演算預測CIK細胞抗癌療效
補助單位
國家科學及技術委員會
計畫名稱
109 細胞活性檢測研究計畫
補助單位
新研國際生化科技股份有限公司
計畫名稱
109 丙型干擾素抗性於上皮細胞間質轉化對免疫檢查點阻斷療法的影響
補助單位
科技部
計畫名稱
108 探討纖連蛋白誘導牙齦上皮細胞間質轉化現象中α5β1整合素調節SHP2的角色
補助單位
科技部
計畫名稱
108 標靶新穎多巴胺D2受體異源受體複合物以作為干擾病毒感染及免疫致病之抗登革策略
補助單位
科技部
計畫名稱
107 細胞損傷誘導之半乳糖凝集素-3在肺纖維化中促進乙型轉型生長因子誘導之間質轉化
補助單位
科技部
計畫名稱
107 醫學科學研究所博士生沈庭靚君擬於108年6月7日至6月12日赴希臘羅德參加第十六屆先天免疫學國際研討會，依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案
補助單位
計畫名稱
106 探討麻醉劑異丙酚抗登革病毒感染之效益
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
106 Development of new dengue virus mouse models for disease pathogenesis and herapeutic strategies－新藥開發並測試於登革病毒感染小鼠模式(3/3)
補助單位
科技部
計畫名稱
105 麻醉劑異丙酚誘導巨噬細胞凋亡中神經醯胺的生成與其角色
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
105 Development of new dengue virus mouse models for disease pathogenesis and therapeutic strategies─新藥開發並測試於登革病毒感染小鼠模式(1/3)-蔡宗婷
補助單位
科技部
計畫名稱
105 Development of new dengue virus mouse models for disease pathogenesis and therapeutic strategies－新藥開發並測試於登革病毒感染小鼠模式(2/3)
補助單位
科技部
計畫名稱
105 微生物及免疫學科申請補助延攬科技人才Tsung-Ting Tsai 蔡宗婷女士參與「Development of new dengue virus mouse models for disease pathogenesis and therapeutic strategies─新藥開發並測試於登革病毒感染小鼠模式(2/3)」
補助單位
科技部
計畫名稱
104 104年9月赴奧地利維也納參加4th
補助單位
科技部
計畫名稱
104 Evasion of fibrotic lung myofibroblasts from IFN-γ immunosurveillance.
補助單位
科技部
計畫名稱
104 神經醯胺生成於麻醉劑異丙酚刺激的巨噬細胞：分子機制與其角色
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
104 肝醣合成酶激酶3於登革病毒感染單核吞噬細胞的潛在角色(3/3)
補助單位
科技部
計畫名稱
104 肝醣合成酶激酶3於登革病毒感染單核吞噬細胞的潛在角色(3/3)
補助單位
科技部
計畫名稱
104 肝醣合成酶激酶3於登革病毒感染單核吞噬細胞的潛在角色-蔡宗婷
補助單位
科技部
計畫名稱
104 Development of new dengue virus mouse models for disease pathogenesis and herapeutic strategies－新藥開發並測試於登革病毒感染小鼠模式(1/3)
補助單位
科技部
計畫名稱
103 The effects of anesthetic propofol on neutrophil survival
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
103 肝醣合成酶激酶3於登革病毒感染單核吞噬細胞的潛在角色(2/3)
補助單位
科技部
計畫名稱
103 肝醣合成?激?3於登革病毒感染單核吞噬細胞的潛在角色(2/3)
補助單位
科技部
計畫名稱
103 肝醣合成酶激酶3於登革病毒感染單核吞噬細胞的潛在角色-蔡宗婷
補助單位
科技部
計畫名稱
103 TMU103-AE1-B03
補助單位
臺北醫學大學新聘教師計畫
計畫名稱
103 (103)新聘教師研究補助-林秋烽教師
補助單位
臺北醫學大學
計畫名稱
102 A POSSIBLE NOVEL TARGET OF INFLAMMATORY BOWEL DISEASE BY GLYCOGEN SYNTHASE KINASE-3 INHIBITION
補助單位
科技部