陳嘉玲(Chen, Chia-Ling) 副教授

Email
chialing66@tmu.edu.tw
現   職
呼吸治療學系 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
成功大學基礎醫學研究所 博士
2002/09~2008/03
成功大學生物化學暨分子生物學研究所 碩士
2000/09~2002/06
東海大學食品科學系 學士
1996/09~2000/06

本校學術經歷

任職單位與職稱[起迄時間]
呼吸治療學系副教授
2022/02/01~
呼吸治療學系助理教授
2017/09/13~2022/01/31
癌症轉譯研究中心助理研究員
2016/11/01~2017/09/12
(舊)轉譯醫學研究中心助理研究員
2015/08/01~2016/10/31
轉譯醫學研究中心(舊)助理研究員
2014/09/24~2015/07/31
轉譯醫學研究中心(舊)專案助理研究員
2014/08/01~2014/09/23

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
成功大學微生物及免疫學研究所博士後研究員
2008/04~2014/07

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2024 Shih FC,Lin CF,Wu YC,Hsu CC,Chen BC,Chang YC, Lin YS, Satria RD, Lin PY, Chen CL*. Desmethylclomipramine triggers mitochondrial damage and death in TGF-β-induced mesenchymal type of A549 cells . Life Sciences .2024 ;(351):122817-1-122817-11

2. 2023 Chen CL ,Tseng PC,Chao YP,Shen TJ,Jhan MK,Wang YT, Nguyene TT, Lin CF. Polypeptide antibiotic actinomycin D induces Mcl-1 uncanonical downregulation in lung cancer cell apoptosis . Life Sciences .2023 ;(321):1-9

3. 2023 Hung YP,Chen CL,Tseng PC,Satria RD,Chen MC,Lin CF. Measurement of lipid droplets in peripheral immune cells shows an immunomodulatory effect on monocyte polarization in experimental dyslipidaemia . Biochem Biophys Res Commun .2023 ;(650):73-80

4. 2022 Chen CL,Tseng PC,Satria RG,Nguyen TT,Tsai CC,Lin CF. Role of glycogen synthase kinase-3 in IFN-γ-mediated immune hepatitis . International Journal of Molecular Sciences .2022

5. 2022 Tseng PC,Chen CL,Lee KY,Feng PH,Wang YC,Satria RD, Lin CF . Epithelial-to-mesenchymal transition hinders interferon-γ-dependent immunosurveillance in lung cancer cells . Cancer Letters .2022 ;(539):1-13

6. 2022 Shen TJ,Chen CL,Tsai TT,Jhan MK,Bai CH,Yen YC, Tsai CW, Tseng PC, Yu CY, Lin CF*. Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation . JCI Insight .2022 ;(7):1-15

7. 2022 Cheng WH,Kao SY,Chen CL,Yuliani FS,Lin LY,Lin CH, Chen BC*. Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells . Respir Res .2022 ;(23):381

8. 2021 Chang CJ,Lin CF,Lee CH,Chuang HC,Shih FC,Wan SW, Tai C, Chen CL*. Overcoming interferon (IFN)-γ resistance ameliorates transforming growth factor (TGF)-β-mediated lung fibroblast-to-myofibroblast transition and bleomycin-induced pulmonary fibrosis . Biochemical Pharmacology .2021 ;(183):114356

9. 2021 Tsai TH,Yang CC,Kou TC,Yang CE,Dai JZ,Chen CL, Lin CW*. Overexpression of GLUT3 promotes metastasis of triple-negative breast cancer by modulating the inflammatory tumor microenvironment . J Cell Physiol .2021

10. 2021 Putri DU#,Chen CL#,Wang CH,Sue YM,Sue YM,Lin CF, Tsai CW, Liu YJ, Lee CH*. Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile . J Microbiol Immunol Infect .2021 ;(S1684-1182):0103-1-0103-4

11. 2021 Cheng WH,Chen CL,Chen JY,Lin CH,Chen BC*. Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway . Mol Med .2021 ;(27):69-83

12. 2021 Chen JY,Cheng WH,Lee KY,Kuo HP,Chung KF,Chen CL, Chen BC, Lin CH*. Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma . Biomedicine & Pharmacotherapy .2021 ;(140):111701-111712

13. 2021 Chang CJ#,Lin CF#,Chen BC,Lin PY,Chen CL*. SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis . IUBMB Life .2021 ;(70):131-142

14. 2020 Lu ZY,Cheng MH,Yu CY,Lin YS,Yeh TM,Chen CL, Chen CC, Wan SW, Chang CP*. Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1 . Int J Mol Sci .2020 ;(21):9702

15. 2020 Chuang HC,Chen HC,Chai PJ,Liao HT,Wu CF,Chen CL, Jhan MK, Hsieh HI, Wu KY, Chen TF, Cheng TJ*. Neuropathology changed by 3- and 6-months low-level PM 2.5 inhalation exposure in spontaneously hypertensive rats . Part Fibre Toxicol .2020 ;(17):59

16. 2020 Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF*. CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain . Front Cell Infect Microbiol .2020 ;(10):557610-557620

17. 2020 Lin YS,Huang IH,Lan SH,Chen CL,Chen YY,Chan NJ, Hsu CC*. Involvement of Capsaicin-Sensitive Lung Vagal Neurons and TRPA1 Receptors in Airway Hypersensitivity Induced by 1,3-β-D-Glucan in Anesthetized Rats . Int J Mol Sci .2020 ;(21):6845

18. 2020 Hsieh TH,Tsai TT,Chen CL,Shen TJ,Jhan MK,Tseng PC, Lin CF*. Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity . Front Cell Infect Microbiol .2020 ;(10):375

19. 2020 Tsai CC,Tsai CK,Tseng PC,Lin CF,Chen CL*. Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4 + T Lymphocytes . Cells .2020 ;(9(6)):1424-1439

20. 2019 Wu SY,Chen CL,Tseng PC,Chiu CY,Lin YE,Lin CF*. Fractionated ionizing radiation facilitates interferon-γ signaling and anticancer activity in lung adenocarcinoma cells . J Cell Physiol .2019 ;(234):16003-10

21. 2019 Tseng PC,Kuo CF,Cheng MH,Wan SW,Lin CF,Chang CP, Lin YS, Wu JJ, Huang CC, Chen CL*. HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection . Frontiers in Immunology .2019 ;(10):1-13

22. 2019 Cheng YL,Kuo CF,Lu SL,Hiroko O,Wu YN,Hsieh CL, Noda T, Wu SR, Anderson R, Lin CF, Chen CL, Wu JJ, Lin YS*. Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy . mBio .2019 ;(10):e02148-19

23. 2019 Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection . Sci Rep .2019

24. 2019 Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity . J Immunol Res .2019

25. 2019 Bai KJ,Chuang KJ,Chen CL,Jhan MK,Hsiao TC,Cheng TJ, Chang LT, Chang TY, Chuang HC*. Microglial activation and inflammation caused by traffic-related particulate matter . Chem-Biol Interact .2019 ;(311):108762-70

26. 2018 Chen CL ,Cheng MH,Kuo CF,Cheng YL,Li MH,Chang CP, Wu JJ, Anderson R, Wang S, Tsai PJ, Liu CC, Lin YS*. Dextromethorphan Attenuates NADPH Oxidase-regulated GSK-3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection . Antimicrob Agents Chemother .2018 ;(60):e02045-17

27. 2017 Tsai TT ,Chen CL ,Tsai CC,Lin CF. Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo . Antiviral Research .2017 ;(145):44-53

28. 2017 Zainal Nurhafiza ,Chang CP,Cheng YL,Wu YW,Anderson Robert ,Wan SW, Chen CL, Ho TS, AbuBakar S, Lin YS.. Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection . Scientific Reports .2017 ;(7)

29. 2017 Chen HH,Chen CC,Lin YS,Chang PC,Lu ZY,Lin CF, Chen CL, Chang CP. AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78 . Antiviral Research .2017 ;(142):158-168

30. 2016 Tsai TT,Chen CL,Lin YS,Chang CP,Tsai CC,Cheng YL, Huang CC, Ho CJ, Lee YC, Lin LT, Jhan MK, Lin CF.. Microglia retard dengue virus-induced acute viral encephalitis . Scientific Reports .2016 ;(6)

31. 2016 Tseng PC,Chen CL,Shan YS,Lin CF. An increase in galectin-3 causes cellular unresponsiveness to IFN-γ-induced signal transduction and growth inhibition in gastric cancer cells . Oncotarget .2016 ;(7):15150-15160

32. 2016 Su YC,Davuluri GVN ,Chen CH,Shiau DC,Chen CC ,Chen CL, Lin YS, Chang CP.. Galectin-1-induced autophagy facilitates cisplatin resistance of hepatocellular carcinoma . PLoS One .2016 ;(11)

33. 2016 Chen CL,Wu YY,Lin CF,Kuo CF,Han CL,Wang S, Chuang WJ, Chen CY, Wu JJ, Tsai PJ, Liu CC, Lin YS. Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage . Scientific Reports .2016 ;(6):26026-26040

34. 2016 Lin CF,Tsai CC,Huang WC,Wang YC,Tseng PC,Tsai TT, Chen CL.. Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis . PLoS One .2016 ;(11):e0145460-74

35. 2015 Chen CL,Chiang TH,Tseng PC,Wang YC,Lin CF. Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ . Biochemical and Biophysical Research Communications .2015 ;(466):578-584

36. 2015 Chiu WH,Su WC ,Li CL ,Chen CL ,Lin CF. An increase in glucosylceramide synthase induces BclxL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells . Oncotarget .2015 ;(6):20513-20524

37. 2014 Wang CY,Yang TT,Chen CL,Lin WC,Lin CF. Reactive oxygen species-regulated glycogen synthase kinase-3β activation contributes to all-trans retinoic acid-induced apoptosis in granulocyte-differentiated HL60 cells . Biochemical Pharmacology .2014 ;(88):86-94

38. 2014 Wang YC,Chen CL,Sheu BS,Yang YJ,Tseng PC,Hsieh CY, Lin CF.. Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-γ signaling . Journal of Immunology .2014 ;(193):4149-4158

39. 2014 Hsieh CY,Chen CL,Lin YS,Yeh TM,Tsai TT,Hong MY, Lin CF.. Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation . Journal of Immunology .2014 ;(193):3693-3703

40. 2013 Yang TT,Chen CL,Lin WC,Lin YS,Tseng PC,Hsieh CY, Chen YH, Huang WC, Tsai CC, Wang CY, Shieh CC, Lin CF.. Glycogen synthase kinase-3β inactivation is an intracellular marker and regulator for endotoxemic neutrophilia . Journal of Molecular Medicine .2013 ;(91):207-217

41. 2013 Chang YT,Chen CL,Lin CF,Lu SL,Cheng MH,Kuo CF, Lin YS.. Regulatory role of GSK-3 β on NF-B, nitric oxide, and TNF-α in group A streptococcal infection . Mediators of Inflammation .2013 ;(2013)

42. 2013 Chen CL,Lin CF,Wan SW,Wei LS,Chen MC,Yeh TM, Liu HS, Anderson R, Lin YS. . Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation . Journal of Immunology .2013 ;(191):1744-1752

研究計畫

計畫名稱
113 肺部纖維化的新穎治療策略:關閉肌成纖維細胞活性同時啟動免疫監控機轉(3/3)
補助單位
國家科學及技術委員會

計畫名稱
113 Doublecortin like kinase 1 (DCLK1)在支氣管肺纖維化中的病理生理角色-探討DCLK1調節上皮細胞間質轉化誘發第二型免疫反應在嚴重氣喘疾病中的角色(3/3)
補助單位
國家科學及技術委員會

計畫名稱
113 「補助國內研究生出席國際學術會議」申請費用補助案(研究生:醫學科學研究所博士班林珮筠君)
補助單位
國家科學及技術委員會

計畫名稱
112 肺部纖維化的新穎治療策略:關閉肌成纖維細胞活性同時啟動免疫監控機轉(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 Doublecortin like kinase 1 (DCLK1)在支氣管肺纖維化中的病理生理角色-探討DCLK1調節上皮細胞間質轉化誘發第二型免疫反應在嚴重氣喘疾病中的角色(2/3)
補助單位
國家科學及技術委員會

計畫名稱
111 肺部纖維化的新穎治療策略:關閉肌成纖維細胞活性同時啟動免疫監控機轉(1/3)
補助單位
國家科學及技術委員會

計畫名稱
111 Doublecortin like kinase 1 (DCLK1)在支氣管肺纖維化中的病理生理角色-探討DCLK1調節上皮細胞間質轉化誘發第二型免疫反應在嚴重氣喘疾病中的角色(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 探究巨噬細胞移動抑制因子於肺纖維化疾病中的免疫病理角色
補助單位
科技部

計畫名稱
109 TXNIP在肺泡巨噬細胞偏向M1/M2極化中的調控:慢性阻塞性肺病致病機轉的研究(3/3)
補助單位
科技部

計畫名稱
109 肺纖維化之分子病理機制探討-探討Sema7A+調節型T細胞在肺部纖維化中第二型免疫反應的調控角色(3/3)
補助單位
科技部

計畫名稱
108 TXNIP在肺泡巨噬細胞偏向M1/M2極化中的調控:慢性阻塞性肺病致病機轉的研究(2/3)
補助單位
科技部

計畫名稱
108 肺纖維化之分子病理機制探討-探討Sema7A+調節型T細胞在肺部纖維化中第二型免疫反應的調控角色(2/3)
補助單位
科技部

計畫名稱
107 Study on the potential anti- pulmonary fibrotic effect of desmethylclomipramine
補助單位
科技部

計畫名稱
107 探討HECT E3泛素連接酶調控熱殺死結核分枝桿菌/TLR誘發之發炎機制
補助單位
科技部

計畫名稱
107 TXNIP在肺泡巨噬細胞偏向M1/M2極化中的調控:慢性阻塞性肺病致病機轉的研究(1/3)
補助單位
科技部

計畫名稱
107 肺纖維化之分子病理機制探討-探討Sema7A+調節型T細胞在肺部纖維化中第二型免疫反應的調控角色(1/3)
補助單位
科技部

計畫名稱
106 探討TXNIP在吸煙導致肺部發炎與慢性阻塞性肺病中的病理生理角色
補助單位
科技部

計畫名稱
105 探討熱源性外毒素B引發胞葬作用的缺失以調節促發炎反應與免疫脫逃機制於A群鏈球菌感染
補助單位
科技部

計畫名稱
104 探討Txnip於尼古丁刺激巨噬細胞誘導炎性蛋白C-reactive protein表現的調控機轉及其病理效應(2/2)
補助單位
科技部

計畫名稱
104 探討Txnip於尼古丁刺激巨噬細胞誘導炎性蛋白C-reactive protein表現的調控機轉及其病理效應(2/2)
補助單位
科技部

計畫名稱
103 探討TXNIP於尼古丁刺激巨噬細胞誘導炎性蛋白C-REACTIVE PROTEIN表現的調控機轉及其病理效應
補助單位
科技部

計畫名稱
103 探討Txnip於尼古丁刺激巨噬細胞誘導炎性蛋白C-reactive protein表現的調控機轉及其病理效應(1/2)
補助單位
科技部

計畫名稱
103 TMU103-AE1-B21
補助單位
臺北醫學大學新聘教師計畫

計畫名稱
103 (103)新聘教師研究補助-陳嘉玲教師
補助單位
臺北醫學大學