| 1. |
2023
Chang CH,Lin BJ,Chen CH,Nguyen NL,Hsieh TH,Su JH, Chen MC.
Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
. Marine Drugs
.2023
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| 2. |
2023
Hsu HL,Lin BJ ,Lin YC,Tu CC,Nguyen NL ,Wang CC, Chen MC, Chen CH .
Cucurbitacin E Exerts Anti-Proliferative Activity via Promoting p62-Dependent Apoptosis in Human Non-Small-Cell Lung Cancer A549 Cells
. Curr Issues Mol Biol. 2023 Oct 7;45(10):8138-8151.
.2023
;(45):8138-8151
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| 3. |
2021
Ojha R,Chen IC,Hsieh CM,Nepali K,Lai RW,Hsu KC, Lin TE, Pan SL, Chen MC, Liou JP. .
Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent.
. Journal of Medicinal Chemistry
.2021
;(XX):XXX-XXX
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| 4. |
2021
Nham-Linh Nguyen,Thanh-Hoa Vo,Yu-Chi Lin,Chia-Ching Liaw,Mei-Kuang Lu,Jing-Jy Cheng, Mei-Chuan Chen*, Yao-Haur Kuo*.
Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities
. J Nat Prod.
.2021
;(84):259-267
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| 5. |
2020
Mehndiratta S,Chen MC,Chao YH,Lee CH,Liou JP,Lai MJ, Lee HY.
Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2020
;(36):74-84
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| 6. |
2020
Lin YC,Chen MC,Hsieh TH, Liou JP,Chen CH.
CK1δ as a potential therapeutic target to treat bladder cancer.
. Aging
.2020
;(12):5764-5780
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| 7. |
2020
Ojha R,Nepali K ,Chen CH,Chuang KH,,Wu TY,Lin TE,Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP..
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.
. Eur J Med Chem.
.2020
;(190):112086-112105
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| 8. |
2020
Nguyen NL,Vo TH,Lin YC,Liaw CC,Lin ZH,Chen MC, Kuo YH.
Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus Thorelii
. Molecules
.2020
;(25):551-565
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| 9. |
2020
Wu WC,Liu YM,Liao YH,Hsu KC,Lien ST,Chen IC, Lai MJ, Li YH, Pan SL, Chen MC, Liou JP.
Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells.
. Eur J Med Chem
.2020
;(203):112540-112553
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| 10. |
2019
Chen MC,Lin YC,Liao YH,Liou JP,Chen CH.
MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells.
. Cancers
.2019
;(11):1617-1632
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| 11. |
2019
Mehndiratta S,Lin MH,Wu YW,Chen CH,Wu TY,Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP.
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression.
. Eur J Med Chem.
.2019
;(185):111725-111739
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| 12. |
2019
Wang SW,Lin MH,Hsu FC,Chen MC,Liou JP,Liu YT, Chen SS, Lee HY.
Synthesis and biological evaluation of 2-quinolineacrylamides.
. Bioorg Med Chem.
.2019
;(28):115250-115259
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| 13. |
2019
Nepali K,Lin MH,Chao MW,Peng SJ,Hsu KC, Eight Lin T, Chen MC, Lai MJ, Pan SL, Liou JP.
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells.
. Bioorg Chem.
.2019
;(91):103119-103131
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| 14. |
2018
Lai MJ,Ojha R,Lin MH,Liu YM, Lee HY,Lin TE, Hsu KC, Chang CY, Chen MC, Nepali K, Chang JY, Liou JP.
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.
. Eur J Med Chem.
.2018
;(162):612-630
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| 15. |
2018
Mei-Chuan Chen ,Guei-Jane Wang ,Yueh-Hsiung Kuo ,Yin-Ru Chiang,Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee .
Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata
. Journal of Food and Drug Analysis
.2018
;(27):111-117
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| 16. |
2017
Tung-Yun Wu,Ting-Yu Cho,Chung-Kung Lu,Jing-Ping Liou,Mei-Chuan Chen.
Identification of 7-(4-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells.
. Sci Rep.
.2017
;(7):1-12
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| 17. |
2017
Kunal Nepali,Hsueh-Yun Lee,Mei-Jung Lai,Ritu Ojha,Tung-Yun Wu,Gu-Xian Wu, Mei-Chuan Chen, Jing-Ping Liou.
Ring-opened tetrahydro-g-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms
. European Journal of Medicinal Chemistry
.2017
;(15):115-127
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| 18. |
2017
Ming-Horng Tsai,Ju fang Liu,Yao-Chang Chiang,Chu-Sung Hu,Lee-Fen Hsu,Yu-Ching Lin, Zih-Chan Lin, Hui-Chun Lee, Mei-Chuan Chen, Chieh-Liang Huang, and Chiang-Wen Lee..
Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells.
. Oncotarget
.2017
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| 19. |
2017
Mei-Chuan Chen,Yi-Chiu Kuo,Chia-Ming Hsu,Yi-Lin Chen,Chien-Chang Shen,Che-Ming Teng, Shiow-Lin Pan.
The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells
. ScientificReports
.2017
;(7):46149-46149
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| 20. |
2017
Chen Mei Chuan ,Cho Ting Yu ,Kuo Yueh Hsiung ,Lee Tzong Huei .
Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea
. Journal of Natural Products
.2017
;(80):2439-2446
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| 21. |
2016
Chen Mei-Chuan ,Huang Hui-Hsuan ,Lai Chin-Yu ,Lin Yi-Jyun ,Liou Jing-Ping .
Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma
. Oncotarget
.2016
;(7):402-17
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| 22. |
2016
Huang HL,Chao MW,Li YC,Chang LH,Chen CH,Chen MC.
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer
. Scientific Reports
.2016
;(6)
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| 23. |
2016
Cho TY,Wang GJ,Ju YM,Chen MC,Lee TH.
Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623
. Journal of the Chinese Chemical Society
.2016
;(63):404-409
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| 24. |
2016
Hung HL,Chao MW,Chen CC,Cheng CC,Chen MC,Lin CF.
LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo.
. Scientific Reports
.2016
;(6)
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| 25. |
2015
Chen MC,Zhou B,Zhang K,Yuan YC,Un F,Hu S, Chou CM, Chen CH, Wu J, Wang Y, Liu X, Smith L, Warden CD, Liu Z, Li H, Su L, Malkas LH, Chung.
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro.
. Mol Pharmacol.
.2015
;(87):996-1005
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| 26. |
2015
Lai MJ,Lee HY,Chuang HY,Chang LH,Tsai AC,Chen MC, Huang HL, Wu YW, Teng CM, Pan SL, Liu YM, Mehndiratta S, Liou.
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of
. J Med Chem.
.2015
;(58):6549-6558
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| 27. |
2015
Liu YM,Lee HY,Lai MJ,Pan SL,Huang HL,Kuo FC, Chen MC, Liou JP..
Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells.
. Org Biomol Chem.
.2015
;(13):10226-10235
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| 28. |
2015
Chen MC,Huang HH,Lai CY,Lin YJ,Liou JP,Lai MJ, Li YH, Teng CM, Yang CR..
Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma.
. Oncotarget
.2015
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| 29. |
2015
Lin RD,Chen MC,Liu YL,Lin YT,Lu MK,Hsu FL, Lee MH..
New Whitening Constituents from Taiwan-Native Pyracantha koidzumii:
. Int J Mol Sci.
.2015
;(16):28598-28613
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| 30. |
2014
Wu SY,Pan SL,Xiao ZY,Hsu JL,Chen MC,Lee KH, Teng CM.
NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.
. Plos One
.2014
;(9):e11222
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| 31. |
2014
Lee HY,Tsai AC,Chen MC,Shen PJ,Cheng YC,Kuo CC, Pan SL, Liu YM, Liu JF, Yeh TK, Wang JC, Chang CY, Chang JY, Liou JP..
Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells.
. J Med Chem.
.2014
;(57):4009-4022
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| 32. |
2014
Mehndiratta S,Chiang YF,Lai MJ,Lee HY,Chen MC.
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
. Bioorg Med Chem.
.2014
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| 33. |
2014
Chen CH,Chen MC,Wang JC,Tsai AC,Chen CS.
Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo.
. Clin Cancer Res.
.2014
;(20):1274-1287
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| 34. |
2013
Chen MC,Chen CH,Liu YN,Wang HP,Pan SL,Teng CM.
TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.
. Cancer Lett.
.2013
;(336):370-378
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| 35. |
2013
Chen MC,Chen CH,Wang JC,Tsai AC,Liou JP,Pan SL, Teng CM..
The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells.
. Cell Death Dis.
.2013
;(19):e810
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| 36. |
2012
Lai CY,Tsai AC,Chen MC,Chang LH,Sun HL,Chang YL, Chen CC, Teng CM, Pan SL..
Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo.
. PLoS One.
.2012
;(8):e42192
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| 37. |
2012
Chen MC,Pan SL,Shi Q,Xiao Z,Lee KH,Li TK, Teng CM..
QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.
. Cancer Sci.
.2012
;(103):80-87
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| 38. |
2011
Chen CH,Huang PH,Chu PC,Chen MC,Chou CC,Wang D, Kulp SK, Teng CM, Wang Q, Chen CS..
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.
. J Biol Chem.
.2011
;(286):9968-9976
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| 39. |
2011
Chen MC,Chen CH,Chuang HC,Kulp SK,Teng CM,Chen CS..
Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells.
. Hepatology
.2011
;(53):148-159
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