高祖仁(Kao, Tzu-Jen) 教授

Email
geokao@tmu.edu.tw
現   職
國際神經醫學碩士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
南卡羅來納大學生物醫學系 博士
2001/08~2006/12
貝勒大學生物系 學士
1997/08~2001/08

本校學術經歷

任職單位與職稱[起迄時間]
國際神經醫學碩士學位學程教授
2022/08/01~
國際神經醫學碩士學位學程籌備處副教授
2022/04/01~2022/07/31
(舊)神經再生醫學博士學位學程副教授
2018/08/01~2022/03/31
(舊)神經再生醫學博士學位學程助理教授
2013/09/05~2018/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
福利委員會主任委員
2020/08/01 ~ 2022/07/31

其它經歷

任職單位與職稱[起迄時間]
無資料!

專長與研究領域

學門領域
幹細胞/再生生物醫學
醫學之生化及分子生物
學術專長
in ovo electroporation
retrograde tracing
confocal imaging
calcium imaging
biochemistry
stripe asssay
time-lapse microscopy

論文著作

清冊下載


1. 2022 Tsou YS,Wang CY,Chang MY,Hsu TI,Wu MT,Wu YH, Tsai WL, Chuang JY, Kao TJ. Vav2 is required for Netrin-1 receptor-class-specific spinal motor axon guidance . Developmental Dynamics .2022 ;(251):444-458

2. 2022 Kao TJ,Wang CY,Hsu TI,Wu YH,Chuang JY,Huang CC, Hsieh CT. TDP-43 is essential for Eph receptor-specific spinal motor axon trajectory into the limb . Neuroscience Research .2022 ;(176):31-39

3. 2021 Chiao CC,Liu YH,Phan NN,An TNT,Ta HDK,Anuraga G, Wu YF, Lee KH, Chuang JY, Wang CY, Kao TJ. Prognosis and genomic analysis of the Proteasome 20S Subunit Alpha (PSMA) family members in clinical breast cancer . diagnostics .2021 ;(11):2220

4. 2021 Cheng LC,Kao TJ,Phan NN,Chiao CC,Yen MC,Chen CF, Hung JH, Jiang JZ, Sun Z, Wang CY, Hsu HP. Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease . Medicine .2021 ;(100):e24321

5. 2021 Tsai WL,Chang CJ,Wang CY,Hsu TI,Chang MY,Wu YH, Chang PS, Lin KL, Chuang JY, Kania A, Kao TJ. Paxillin is required for proper spinal motor axon growth into the limb . Journal of Neuroscience .2021 ;(24):3808-3821

6. 2021 Choy TK,Wang CY,Phan NN,Ta HDK,Anuraga G,Liu YH, Wu YF, Lee KH, Chuang JY, Kao TJ. Identification of Dipeptidyl Peptidase (DPP) Family Genes in Clinical Breast Cancer Patients via an Integrated Bioinformatics Approach . Diagnostics .2021 ;(11):1204

7. 2021 Kao TJ,Wu CC,Phan NN,Liu YH,Khoa HD,Anuraga G, Wu YF, Lee KH, Chuang JY, Wang CY. Prognoses and genomic analyses of PSMC family genes in clinical breast cancer . Aging .2021

8. 2021 Ho MH,Yen CH,Hsieh TH,Kao TJ,Chiu JY,Chiang YH, Hoffer BJ, Chang WC, Chou SY. CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury . Redox Biology .2021 ;(46):102067

9. 2021 Prayugo FB,Kao TJ,Anuraga G,Ta HDK,Chuang JY,Lin LC, Wu YF, Wang CY, Lee KU. Expression profiles and prognostic value of FABPs in colorectal carcinomas . Biomedicines .2021 ;(9):1460

10. 2020 Limanjaya I,Hsu TI,Chuang JY,Kao TJ. L-selectin activation regulates Rho GTPase activity via Ca+2 influx in Sertoli cell line, ASC-17D cells . Biochem Biophys Res Commun .2020 ;(525):1011-1017

11. 2020 Lo WL,Hsu TI,Yang WB,Kao TJ,Wu MH,Huang YN, Yeh SH, Chuang JY. Betulinic acid-mediated tuning of PERK/CHOP signaling by sp1 inhibition as a novel therapeutic strategy for glioblastoma . Cancers .2020 ;(12):981-981

12. 2020 Chen TC,Chuang JY,Ko CY,Kao TJ,Yang PY,Yu CH, Liu MS, Hu SL,Tsai YT, Chan H, Chang WC, Hsu TI. AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis . Redox Biol .2020 ;(30):101413-101413

13. 2019 Lin HY,Ko CY,Kao TJ,Yang WB,Tsai YT,Chuang JY, Hu SL, Yang PY, Lo WL, Hsu TI. CYP17A1 maintains the survival of glioblastomas by regulating SAR1-mediated endoplasmic reticulum health and redox homeostasis . Cancers .2019 ;(11):1378-1378

14. 2019 Tsai YT,Wu AC,Yang WB,Kao TJ,Chuang JY,Chang WC , Hsu TI. Angptl4 induces tmz resistance of glioblastoma by promoting cancer stemness enrichment via the egfr/akt/4e-bp1 cascade . International Journal of Molecular Sciences .2019 ;(20):5625-5625

15. 2019 Lin HC,Ching YH,Huang CC,Pao PC,Lee YH,Chang WC, Kao TJ, Lee YC. Promyelocytic Leukemia Zinc Finger Is Involved in the Formation of Deep Layer Cortical Neurons . . Journal of Biomedical Science .2019 ;(26):30-43

16. 2019 Lin HC,Ko CY,Lee KH,Chen IH,Kao TJ,Chang WC, Hsu TI, Lee YC. E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells . Biochem Biophys Res Commun .2019 ;(512):629-634

17. 2019 Kuo CJ,Huang CC,Chou SY,Lo YC,Kao TJ,Huang NK, Lin C, Lin HC, Lin HC, Lee YC. Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex. . Phytomedicine .2019 ;(54):132-139

18. 2019 Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ, Ko CY. CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation. . Journal of Neuroinflammation .2019 ;(16):146

19. 2019 Croteau LP,Kao TJ,Kania A. Ephrin-A5 potentiates netrin-1 axon guidance by enhancing Neogenin availability. . Scientific Reports .2019 ;(9):1-17

20. 2018 Chang CJ,Chang MY,Chou SY,Huang CC,Chuang JY,Hsu TI, Chang HF, Wu YH, Wu CC, Morales D, Kania A, Kao TJ. Ephexin1 is required for Eph-mediated limb trajectory of spinal motor axons. . Journal of Neuroscience .2018 ;(38):2043-2056

21. 2018 Nck2 is essential for limb trajectory selection by spinal motor axons . Developmental Dynamics .2018 ;(247):1043-1056

22. 2018 Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43-UBI (+)-related neurodegenerative pathology. . Journal of Biomedical Science .2018 ;(25):76

23. 2018 Kuo CJ,Huang CC,Chou SY,Lo YC,Kao TJ,Huang NK, Lin C, Lin HC, Lin HC, Lee YC. Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex. . Phytomedicine .2018 ;(54):132-139

24. 2018 Wu CC,Lee PT,Kao TJ,Chou SY,Su RY,Lee YC, Yeh SH, Liou JP, Hsu TI, Su TP, Chuang CK, Chang WC, Chuang JY. Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress . Redox Biology .2018 ;(19):74-80

25. 2018 Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH, Lin HC, Shen CKJ, Chang WC, Huang CC. Znf179 E3 ligase-mediated TDP-43 polybiquitination is involved in TDP-43-ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology . Journal of Biomedical Science .2018 ;(25)

26. 2017 Chuang JY,Kao TJ,Lin SH,Wu AC,Lee PT,Su TP, Yeh SH, Lee YC, Wu CC, Chang WC. Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury . Redox Biology .2017 ;(11):135-143

27. 2017 Varadarajan SG,Kong JH,Phan KD,Kao TJ,Panaitof SC,Cardin J, Eltzschiq H, Kania A, Novitch BG, Bulter SJ. Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord. . Neuron .2017 ;(94):790-799

28. 2017 Lee KH,Chen CL,Lee YC,Kao TJ,Chen KY,Fang CY, Chang WC, Chiang YH, Huang CC. Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway. . Sci Rep .2017 ;(7):4787

29. 2017 Chang KY,Hsu TI,Hsu CC,Tsai SY,Liu JJ,hou SW, Liu MS, Liou JP, Ko CY, Chen KY, Hung JJ, Chang WC, Chuang CK, Kao TJ, Chuang JY. Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguianine-DNA methyltransferase. . Redox Biol .2017 ;(13):655-664

30. 2016 Li IH,Ma KH,Kao TJ,Lin YY,Weng SJ,Yen TY, Chen LC, Huang YS. Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine (‘ecstasy’)-induced serotonergic neurotoxicity . NeuroToxicology .2016 ;(52):114-126

31. 2015 Kao TJ,Nicholl GC,Johansen JA,Kania A,Beg AA. α2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles. . J Neurosci .2015 ;(35):2344-2357

32. 2015 Poliak S,Morales D,Croteau LP,Krawchuk D,Palmesino E,Morton S, Jean-Francois C, Charron F, Ackerman SL, Kao TJ, Kania A. Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons . eLife .2015 ;(4):e10841-0

33. 2012 Dudanova I,Kao TJ,Hermann JE,Zheng B,Kania A,Klein R. Genetic evidence for a contribution of Eph:ephrinA reverse signaling to motor axon guidance. . J Neurosci .2012 ;(32):5209-5215

34. 2011 KaoTJ,Law C,Kania A. Eph and ephrin signaling: lessons learned from spinal motor neurons. . Semin Cell Dev Biol .2011 ;(23):83-91

35. 2011 Kao TJ,Kania A. Ephrin-mediated cis-attenuation of Eph receptor signaling is essential for spinal motor axon guidance. . Neuron .2011 ;(71):76-91

36. 2010 Palmesino E,Rousso DL,Kao TJ,Klar A,Laufer E,Uemura O, Okamoto H, Novitch BG, Kania A. Foxp1 and Ihx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. . PLos Biol .2010 ;(8):e10004-e10004

37. 2009 Kao TJ,Palmesino E,Kania A. Src family kinases are required for limb trajectory selection by spinal motor axons. . J Neurosci .2009 ;(29):5690-5700

38. 2007 Kao TJ,Millette CF. L-type voltage-operated Ca+2 channels modulate transient Ca+2 influx triggered by activation of Sertoli cell surface L-selectin. . J Cell Biochem .2007 ;(101):1023-1037

研究計畫

計畫名稱
113 探討趨化因子及其受體在神經網絡形成過程中所扮演的關鍵角色(1/3)
補助單位
國家科學及技術委員會

計畫名稱
112 探討引導受體與配體之間的cis-弱化互動對脊髓運動神經迴路形成的影響(3/3)
補助單位
國家科學及技術委員會

計畫名稱
111 探討引導受體與配體之間的cis-弱化互動對脊髓運動神經迴路形成的影響(2/3)
補助單位
國家科學及技術委員會

計畫名稱
110 探討引導受體與配體之間的cis-弱化互動對脊髓運動神經迴路形成的影響(1/3)
補助單位
科技部

計畫名稱
109 探討家族遺傳性肌萎縮性脊髓側索硬化症的基因突變對胚胎發育的影響及其應用
補助單位
科技部

計畫名稱
108 探討ephrin與Netrin訊息在神經系統發育時期增效整合作用之機制
補助單位
科技部

計畫名稱
107 Paxillin在脊髓運動神經軸突引導中的功能
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
107 探討Wnt訊息與程序性細胞凋亡對脊髓運動神經迴路形成的影響(3/3)
補助單位
科技部

計畫名稱
106 探討Wnt訊息與程序性細胞凋亡對脊髓運動神經迴路形成的影響(2/3)
補助單位
科技部

計畫名稱
105 家族遺傳性肌萎縮性脊髓側索硬化症的基因突變在胚胎發育過程中所造成的影響
補助單位
阮綜合醫療社團法人阮綜合醫院

計畫名稱
105 探討Wnt訊息與程序性細胞凋亡對脊髓運動神經迴路形成的影響(1/3)
補助單位
科技部

計畫名稱
105 探討Wnt訊息與程序性細胞凋亡對脊髓運動神經迴路形成的影響(1/3)
補助單位

計畫名稱
104 Ephs與Netrin受體在脊髓運動神經中的互動機制
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
104 Netrin-1與ephrin訊息的協同作用,對脊髓運動神經發育所扮演的角色
補助單位
科技部

計畫名稱
103 Ephexin-1在脊髓運動神經的軸突引導中所扮演的角色
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
103 研究不同引導物質之間的協同作用,對脊髓運動神經發育所扮演的角色(2/2)
補助單位
行政院國家科學委員會

計畫名稱
102 Ephs與ephrins的多種相互作用,對脊髓運動神經的軸突引導所扮演的角色
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
102 研究不同引導物質之間的協同作用,對脊髓運動神經發育所扮演的角色(1/2)
補助單位
行政院國家科學委員會

計畫名稱
102 研究不同引導物質之間的協同作用,對脊髓運動神經發育所扮演的角色(2/2)
補助單位
科技部

計畫名稱
102 研究不同引導物質之間的協同作用、對髓運動神經發育所扮演的角色(1-2)
補助單位
科技部

計畫名稱
102 TMU102-AE1-B22
補助單位
臺北醫學大學新聘教師計畫