潘俊旭(Pan, Chun-Hsu) 專案助理教授

Email
panch@tmu.edu.tw
現   職
新藥研發產業博士學位學程 專案助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
交通大學生化工程研究所 博士
2003/09~2009/01
中國醫藥學院醫學研究所 碩士
2001/09~2003/07
中國醫藥學院營養系 學士
1998/09~2001/07

本校學術經歷

任職單位與職稱[起迄時間]
新藥研發產業博士學位學程專案助理教授
2020/08/01~
(舊)生技醫療產業研發博士學位學程專案助理教授
2020/05/01~2020/07/31
藥物科學學科專案助理教授
2014/03/25~2020/04/30
藥物科學學科助理研究員
2013/09/01~2014/03/24

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥物科學學科專案助理教授
2020/05/01 ~

其它經歷

任職單位與職稱[起迄時間]
無資料!

專長與研究領域

學門領域
藥理及毒理
保健營養
醫學之生化及分子生物
中醫藥
藥學
學術專長
Western blot
Ascending aortic banding (animal model)
in-gel zymography
xenograft tumor model (animal model)
DNA cloning and transformation
Immunohistochemical assay
electroporation
flow cytometry
Luciferase-based reporter assay
wire injury and balloon angioplasty (animal model)
Real-time PCR
Primary cells isolation
High-performance liquid chromatograph
Cell migration and invasion assay
Tube formation assay
MTT assay
Laser scanning confocal microscopy

論文著作

清冊下載


1. 2024 Thakur A,Mishra A,Rana M,Pan CH,Kaur C,Nepali K*. Recent Advances and Future Directions on Small Molecule VEGFR Inhibitors in Oncological Conditions . European Journal of Medicinal Chemistry .2024 ;(272)

2. 2024 Thakur A,Chu YH,Rao V,Mathew J,Grewal AS,Prabakaran P, Guru S, Liou JP, Pan CH*, Nepali K*. Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation . European Journal of Medicinal Chemistry .2024 ;(273)

3. 2023 Thakur A,Rana M,Sachdeva R,Matthew J,Sanya N,Pan CH, Liou JP, Nepali K*. Small Molecule Tractable PARP Inhibitors: Scaffold Construction Approaches, Mechanistic Insights and Structure Activity Relationship . Bioorganic Chemistry .2023 ;(141)

4. 2023 Rana M,Thakur A,Kaur C,Pan CH,Lee SB,Liou JP, Nepali K*. Prudent Tactics to Sail the Boat of PARP Inhibitors as Therapeutics for Diverse Malignancies . Expert Opinion on Drug Discovery .2023 ;(18):1169-1193

5. 2023 Zumbi CN,Pan CH,Huang HY,Wu CH*. Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signalling pathway . Food Science and Human Wellness .2023

6. 2022 Sharma R,Chatterjee E,Mathew J,Sharma S,Rao NV,Pan CH, Lee SB, Dhingra A, Grewal AS, Liou JP, Guru SK, Nepali K. Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier . European Journal of Medicinal Chemistry .2022 ;(240)

7. 2022 Tung YT,Wu CH,Chen WC,Pan CH,Chen YW,Tsao SP, Chen CJ, Huang HY. Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats . Nutrients .2022 ;(14)

8. 2022 Nurrahma BA,Yeh TH,Hsieh RH,Tsao SP,Chen CW,Lee YP, Pan CH, Huang HY*. Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit 6-OHDA-Induced Parkinson's Disease . Antioxidants .2022 ;(11)

9. 2021 Pan CH,Chien SC,Chen CJ,Shih CM,Hsieh MH,Huang CY, Bi WF, Chan CS, Kao YT, Hsiao CY, Chiang SJ, Chiang KH, JHuang JH, Liu YR, Luo JD, Huang HY, Wu CH. Circulating level of microRNA‑142‑5p is a potential biomarker for predicting in‑stent restenosis: a case–control study . BMC Cardiovascular Disorders .2021 ;(21):77-77

10. 2021 Chen LH,Wang MF,Chang CC,Huang SY,Pan CH,Yeh YT, Huang CH, Chan CH, Huang HY. Lactobacillus paracasei PS23 effectively modulates gut microbiota composition and improves gastrointestinal function in aged SAMP8 mice . Nutrients .2021 ;(13):1116

11. 2021 Pan CH,Lin YP,Wang JY,Huang HY,Huang SC,Lo JM, Wu CH*. Preventive effect and mechanism of Crossostephium chinense extract on balloon angioplasty–induced neointimal hyperplasia . Evidence-Based Complementary and Alternative Medicine .2021 ;(2021)

12. 2021 Pan CH,Chien YC,Sung MS,Huang HY,Sheu MJ,Wu CH. Pathological Role of Phosphoglycerate Kinase 1 in Balloon Angioplasty-Induced Neointima Formation . International Journal of Molecular Sciences .2021 ;(22):8822

13. 2021 Chen LH,Pan CH,Huang SY,Chan CH,Huang HY. The Immunomodulatory Effects of Long-Term Supplementation with Lactobacillus casei Shirota Depend on Ovalbumin Presentation in BALB/c Mice . Scientific Reports .2021 ;(11)

14. 2021 Chen LH,Chang SS,Chang HY,Wu CH,Pan CH,Chang CC, Chan CH, Huang HY. Probiotic supplementation attenuates age-related sarcopenia via the gut–muscle axis in SAMP8 mice . Journal of Cachexia, Sarcopenia and Muscle .2021

15. 2020 Huang WC,Pan CH,Wei CC,Huang HY. Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation . Nutrients .2020 ;(12)

16. 2020 Tung YT,Pan CH,Chien YW,Huang HY. Edible mushrooms: Novel medicinal agents to combat metabolic syndrome and associated diseases . Current Pharmaceutical Design .2020

17. 2020 Pan CH,Chen SY,Wang JY,Tsao SP,Huang HY,Chiu PWC, Wu CH. Sclareol Ameliorated ERCC1-mediated Cisplatin Resistance in A549 Human Lung Adenocarcinoma Cells and a Murine Xenograft Tumor Model by Suppressing AKT-GSK3β-AP1/Snail and JNK-AP1 Pathways . Chemico-Biological Interactions .2020 ;(332)

18. 2019 Hsien-Feng Liao,Ying-Ping Juan,Chun-Hsu Pan. 淺談FAAH(rs324420)藥物基因體學 . 藥學雜誌 .2019 ;(35):40-45

19. 2019 Pan CH,Chen CJ,Shih CM,Wang MF,Wang JY,Wu CH. Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta . Aging .2019 ;(11)

20. 2018 Wu CH,Liu FC,Pan CH,Lai MT,Lan SJ,Wu CH, Sheu MJ*. Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model . International Journal of Molecular Sciences .2018 ;(19):791-805

21. 2017 Liao HF,Pan CH,Chou PY,Chen YF,Wu TS,Sheu MJ, Wu CH. Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells. . PLoS One .2017 ;(12)

22. 2017 Pan CH,Li PC,Chien YC,Yeh WT,Liaw CC,Sheu MJ, Wu CH*. Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty‐induced neointimal hyperplasia . Phytotherapy Research .2017

23. 2016 Wu CH,Pan CH,Lee CK,Sheu MJ,Liu FC,Wang GJ, Wu CH. Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans . Journal of Functional Foods .2016 ;(24):173-182

24. 2016 Chung YL,Pan CH,Wang CCN,Hsu KC,Sheu MJ,Chen HF, Wu CH. Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo . Journal of Natural Products .2016

25. 2015 Li PC,Sheu MJ,Ma WF,Pan CH,Sheu JH,Wu CH. Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells . Marine drugs .2015 ;(13):3046-3060

26. 2014 Chen SC,Chien YC,Pan CH,Sheu JH*,Chen CY*,Wu CH*. Inhibitory effect of Dihydroaustrasulfone alcohol on the migration of human non-small cell lung carcinoma A549 cells and the antitumor effect on a Lewis lung carcinoma-bearing tumor model in C57BL/6J mice . Marine Drugs .2014 ;(12):196-213

27. 2014 Pei-Chuan Li,Chun-Hsu Pan,Ming-Jyh Sheu,Chin-Ching Wu,Wei-Fen Ma,Chieh-Hsi Wu*. Deep Sea Water Prevents Balloon Angioplasty-Induced Hyperplasia through MMP-2: An in Vitro and in Vivo Study . PLOS One .2014 ;(9):e96927

28. 2014 Chun-Hsu Pan,Wen-Hsin Lin,Yi-Chung Chien,Fon-Chang Liu,Ming-Jyh Sheu,Yueh-Hsiung Kuo*, Chieh-Hsi Wu*. K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2 . Toxicology and Applied Pharmacology .2014 ;(282):215-226

29. 2014 Chung YL†,Pan CH†,Liou WH,Sheu MJ,Lin WH,Tsung-Chih Chen, Hsu-Shan Huang, Chieh-Hsi Wu*. NSC746364, a G-Quadruplex Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells through Activation of ATR/Chk1-Dependent Pathway . Journal of Pharmacological Sciences .2014 ;(124):7-17

30. 2013 Sheu MJ,Chou PY,Lin WH,Pan CH,Chien YC,Chung YL, Liu FC, Wu CH*. Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via AMPK-ACC Pathway: an in vivo Study . Marine Drugs .2013 ;(11):2183-2202

31. 2013 Liu FC,Pan CH,Lai MT,Chang SJ,Chung JG,Wu CH*. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALB/C Allograft Tumor Model . Evidence-based Complementary and Alternative Medicine .2013 ;(2013):68407

32. 2013 Pan CH†,Tsai CH†,Liu FC,Fan MJ,Sheu MJ,Hsieh WT, Wu CH*. Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model . Journal of the Science of Food and Agriculture .2013 ;(93):1278-1283

33. 2012 Huang GJ,Pan CH,Wu CH*. Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated RAW246.7 macrophages and the λ-carrageenan-induced paw edema model . Journal of Natural Products .2012 ;(75):54-59

34. 2012 Huang GJ,Pan CH,Liu FC,Wu TS,Wu CH*. Anti-inflammatory effects of ethanolic extract of Antrodia Salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the -carrageenan-induced paw edema model . Food and Chemical Toxicolog .2012 ;(50):1485-1493

35. 2012 Pan CH,Tsai CH,Lin WH,Chen GY,Wu CH*. Ethanolic extract of Vitis thunbergii exhibits lipid lowering properties via modulation of the AMPK-ACC pathway in hypercholesterolemic rabbits . Evidence-Based Complementary and Alternative Medicine .2012 ;(2012):436786

36. 2012 Wang HH†,Pan CH†,Wu PP,Luo SF,Lin HJ,Wu CH*. Alteration of the tongue manifestation reflects clinical outcomes of peptic ulcer disease . Journal of Alternative and Complementary Medicine .2012 ;(18):1038-1044

37. 2012 Pan CH,Chen CW,Sheu MJ,Wu CH*. Salvianolic acid B inhibit SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor . Vascular Pharmacology .2012 ;(56):98-105

38. 2011 Wu RSC,Huang CC,Pan CH,Wu KC,Chen CC,Liu SK, Tang CL, Wu CH*. Total sleep deprivation augments balloon angioplasty-induced neointimal hyperplasia in rat . Experimental Physiology .2011 ;(96):1239-1247

39. 2011 Chou PY,Huang GJ,Pan CH,Chien YC,Chen YY,Wu CH, Sheu MJ, Cheng HC*. Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway . American Journal of Chinese Medicine .2011 ;(39):803-815

40. 2010 Pan CH,Hsieh IC,Liu FC,Hsieh WT,Sheu MJ,Koizumi A, Wu CH*. Effects of a Chinese Herbal Health Formula, “Gan-Lu-Yin”, on Angiogenesis . Journal of Agricultural and Food Chemistry .2010 ;(58):7685-7692

41. 2010 Lin CS*,Pan CH,Wen CH,Yang TH,Kuan TH. Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts . Peptides .2010 ;(31):1334-1340

42. 2008 Pan CH,Wen CH,Lin CS*. Interplay of angiotensin II and angiotensin 1-7 in the regulations of matrix metalloproteinases of human cardiocytes . Experimental Physiology .2008 ;(93):599-612

43. 2008 Lin CS*,Pan CH. Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation . Cellular and Molecular Life Sciences .2008 ;(65):1489-1508

44. 2007 Pan CH,Lin JL,Lai LP,Chen CL,Huang SKS,Lin CS*. Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation . FEBS Letters .2007 ;(581):526-534

45. 2007 Chen CL,Lin JL,Lai LP,Pan CH,Huang SKS,Lin CS*. Altered expression of FHL1, CARP, TSC-22 and P311 provide insights into complex transcriptional regulation in pacing-induced atrial fibrillation . Biochimica et biophysica acta-Molecular basis of disease .2007 ;(1772):317-329

46. 2005 Wu CH,Pan JS,Chang WC,Hung JS,Mao SJT*. The molecular mechanism of actinomycin D in preventing neointimal formation in rat carotid arteries after balloon injury . Journal of Biomedical Science .2005 ;(12):503-512

47. 2005 Ko YT*,Pan CH,Lee YT,Chang JY. Detection of proteins related to starch synthase activity in the developing mungbean (Vigna radiata L.) . Journal of Agricultural and Food Chemistry .2005 ;(53):4805-4812

48. 2005 潘俊旭,謝柏昌,徐繹翔,王瑞萍,古家禎,林志生*. 血管藥物塗層支架之專利趨勢分析 . 化工資訊與商情 .2005 ;(22):68-74


1. 2005 林志生,蔡明蒔,潘俊旭,孫玉苓,王瑞萍,黃元平, 張豐鵬. 微奈米生物感測系統專利地圖及分析 . 奈米科技專利研究系列 .2005

研究計畫

計畫名稱
110 具選擇性血管細胞靶向之新穎支架藥物開發與其藥理機制探索
補助單位
科技部