皇甫維君(HuangFu, Wei-Chun) 副教授

Email
clarehf@tmu.edu.tw
現   職
癌症生物學與藥物研發研究所 副教授
醫學科技學院 副院長

學經歷

學 歷

畢業學校與學位[修業時間]
North Carolina State UniversityMolecular & Cellular Toxicology 博士
2002/09~2007/05
Duke UniversityEnvironmental Toxicology 碩士
2000/09~2002/05
清華大學原子科學 學士
1995/09~1998/06

本校學術經歷

任職單位與職稱[起迄時間]
癌症生物學與藥物研發研究所副教授
2019/02/01~
癌症生物學與藥物研發研究所助理教授
2018/12/01~2019/01/31
癌症生物學與藥物研發博士學位學程助理教授
2013/08/01~2018/11/30

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
癌症生物學與藥物研發博士學位學程主任
2024/03/14 ~ 2024/07/31
醫學科技學院副院長
2023/03/01 ~
癌症生物學與藥物研發博士學位學程助理教授
2019/01/01 ~
國際研究組組長
2019/01/01 ~ 2019/12/31
(舊)生技醫療產業研發博士學位學程助理教授
2018/01/01 ~

其它經歷

任職單位與職稱[起迄時間]
臺北醫學大學博士後研究
2012/04~2013/07
中央研究院博士後研究
2011/10~2012/03
藥莘醫藥資深研究員
2010/10~2011/10
賓州大學博士後研究
2007/06~2010/08
中央研究院研究助理
1998/07~2000/06

專長與研究領域

學門領域
醫學之生化及分子生物
藥理及毒理
學術專長
Western analysis
FACS analysis

論文著作

清冊下載


1. 2024 Tze-Sian Chan,Li-Hsin Cheng,Chung-Chi Hsu,Pei-Ming Yang,Tai-Yan Liao,Hsiao-Yen Hsieh, Pei-Chun Lin, Wei-Chun HuangFu, Chih-Pin Chuu, Kelvin K. Tsai. ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells . Molecular Oncology .2024 ;(18):562-579

2. 2024 Tony Eight Lin,Dyan Yen,Wei-Chun HuangFu,Yi-Wen Wu,Jui-Yi Hsu,Shih-Chung Yen, Tzu-Ying Sung, Jui-Hua Hsieh, Shiow-Lin Pan, Chia-Ron Yang, Wei-Jan Huang, Kai-Cheng Hsu. An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors . Protein Science .2024 ;(33):1-15

3. 2024 Sushree Shankar Panda,Chi-Chiu Lee,Khamushavalli Geevimaan,Kai-Chi Chen,Shung-Haur Yang,Chia-Ning Shen, Wei-Chun HuangFu, Han-Chung Wu . Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression . J Biomed Sci .2024 ;(31)

4. 2023 Huang-Ju Tu,Chih-Jou Su,Chao-Shiang Peng,Tony Eight Lin,Wei-Chun HuangFu,Kai-Cheng Hsu, Tsong-Long Hwang, Shiow-Lin Pan. Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity . J Food Drug Anal .2023 ;(31):358-370

5. 2023 Chen-Wei Chiang,Yun-Shih Lin,Fu-Ling Chang,Tsai-Yu Lin,Keng-Chang Tsai,Wei-Chun HuangFu, Yu-Ching Lee. Single-chain fragment antibody disrupting the EphA4 function as a therapeutic drug for gastric cancer . Biochemical and Biophysical Research Communications .2023 ;(680):161-170

6. 2023 Yi-Wen Wu,Wei-Chun HuangFu,Tony Eight Lin,Chao-Hsiang Peng,Huang-Ju Tu,Ting-Yi Sung, Tzu-Ying Sung, Shih-Chung Yen, Shiow-Lin Pan, Kai-Cheng Hsu. Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule . International Journal of Biological Macromolecules .2023 ;(259):1-13

7. 2022 Tony Eight Lin, Min-Wu Chao,Wei-Chun HuangFu,Huang-JuTu, Zhao-Xiang Peng,Chih-Jou Su, Tzu-Ying Sung, Jui-Hua Hsieh, Cheng-Chung Lee, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu. Identification and analysis of a selective DYRK1A inhibitor . Biomedicine & Pharmacotherapy .2022 ;(146):1-12

8. 2022 Shih-Chung Yen,Liang-Chieh Chen,Han-Li Huang,Wei-Chun HuangFu,Yi-Ying Chen,Tony Eight Lin, Ssu-Ting Lien, Hui-Ju Tseng, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Shiow-Lin Pan, Kai-Cheng Hsu . Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach . Bioorganic Chemistry .2022 ;(121):1-14

9. 2022 Shih-Chung Yen,Yi-Wen Wu,Cheng-Chiao Huang,Min-Wu Chao,Huang-Ju Tu,Liang-Chieh Chen, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Jung-Chun Chu, Wei-Jan Huang, Chia-Ron Yang, Wei-Chun HuangFu, Shiow-Lin Pan, Kai-Cheng Hsu . O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia . Phytomedicine .2022 ;(100):1-12

10. 2021 Min-Wu Chao,Tony Eight Lin,Wei-Chun HuangFu,Chao-Di Chang,Huang-Ju Tu,Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu. Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach . J Enzyme Inhib Med Chem .2021 ;(36):98-108

11. 2021 Ting-Yi Sung,Han-Li Huang,Chun-Chun Cheng,Fu-Ling Chang,Po-Li Wei,Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu, Shiow-Lin Pan. EGFL6 promotes colorectal cancer cell growth and mobility and the anti‐cancer property of anti-EGFL6 antibody . Cell & Bioscience .2021 ;(11):1-14

12. 2021 Yi-Wen Wu,Min-Wu Chao,Huang-Ju Tu,Liang-Chieh Chen,Kai-Cheng Hsu,Jing-Ping Liou, Chia-Ron Yang, Shih-Chung Yen, Wei-Chun HuangFu, Shiow-Lin Pan. A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo . Oncogenesis .2021 ;(10):1-14

13. 2020 Chiu, Po-Yu,HuangFu, Wei-Chun,Liu, I-Hsuan,Chang, Ya-Pei. Topical application of Heparanase-1 facilitates bone remodeling during the healing of bone defects in a mouse model . Journal of the Chinese Medical Association .2020

14. 2020 Yen-Tzu Tseng,Chun-Lin Ko,Chia-Teng Chang,Yen-Hua Lee,Wei-Chun Huang Fu,I-Hsuan Liu. Leucine-rich Repeat Containing 8A Contributes to the Expansion of Brain Ventricles in Zebrafish Embryos . Biol Open .2020 ;(9)

15. 2020 Chao-Feng Lin,Kai-Cheng Hsu,Wei-Chun HuangFu,Tony Eight Lin,Han-Li Huang,Shiow-Lin Pan. Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury . BMC Pharmacol Toxicol .2020 ;(21)

16. 2020 Yen-Hua Lee,Koichi Kawakami,Wei-Chun HuangFu,I-Hsuan Liu. Chondroitin Sulfate Proteoglycan 4 Regulates Zebrafish Body Axis Organization via Wnt/planar Cell Polarity Pathway . PLoS One .2020 ;(15)

17. 2020 Kai-Cheng Hsu,Wei-Chun HuangFu,Tony Eight Lin,Min-Wu Chao,Tzu-Ying Sung,Yi-Ying Chen, Shiow-Lin Pan, Jih-Chin Lee, Shey-Cherng Tzou, Chung-Ming Sun, Jinn-Moon Yang. A Site-Moiety Map and Virtual Screening Approach for Discovery of Novel 5-LOX Inhibitors . Sci Rep .2020 ;(10):1-12

18. 2020 Liang-Chieh Chen,Han-Li Huang,Wei-Chun HuangFu,Shih-Chung Yen,Sin-Ting Ngo,Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu. Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia . J Nat Prod .2020 ;(83):2967-2975

19. 2020 Yen-Tzu Tseng,Shang-Wei Li,Wei-Chun HuangFu,Yun Yen,I-Hsuan Liu. The single nucleotide variant at c.662A>G in human RRM2B is a loss-of-function mutation . Mol Genet Genomic Med .2020 ;(8):e1497

20. 2020 Chia-Teng Chang,Yen-Hua Lee,Wei-Chun HuangFu,I-Hsuan Liu. Cell-intrinsic Fgf signaling contributes to primordial germ cell homing in zebrafish . Theriogenology .2020 ;(158):424-431

21. 2018 RituOjha,Han-Li Huang,Wei-Chun HuangFu, Yi-Wen Wu,Kunal Nepali,Mei-Jung Lai, Chih-Jou Su, Ting-Yi Sung, Yi-Lin Chen, Shiow-Lin Pan, Jing-Ping Liou. 1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC . Eur J Med Chem .2018 ;(150):667-677

22. 2018 Yi-Wen Wu,Kai-Cheng Hsu,Hsueh-Yun Lee,Tsui-Chin Huang,Tony E. Lin,Yi-Ling Chen, Ting-Yi Sung, Jing-Ping Liou, Wendy W. Hwang-Verslues, Shiow-Lin Pan, Wei-Chun HuangFu. A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo . Front. Pharmacol. .2018 ;(9):1-16

23. 2018 Ming‐Kai Jhan,Wei‐Chun HuangFu,Yi‐Fan Chen,Jo‐Chi Kao,Tsung‐Ting Tsai,Min‐Ru Ho, Ting‐Jing Shen, Po‐Chun Tseng, Yung‐Ting Wang, Chiou‐Feng Lin. Anti‐TNF‐α restricts dengue virus‐induced neuropathy . Journal of Leukocyte Biology .2018 ;(104):961-968

24. 2018 Jo-Chi Kao,Wei-Chun HuangFu,Tsung-Ting Tsai,Min-Ru Ho,Ming-Kai Jhan,Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Chiou-Feng Lin. The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR . PLoS Neglected Tropical Diseases .2018 ;(12):1-16

25. 2018 Quan-Liang Jian,Wei-Chun HuangFu,Yen-Hua Lee,I-Hsuan Liu. Age but not short-term intensive swimming affects chondrocyte turnover in zebrafish vertebral cartilage . PeerJ .2018 ;(6):1-23

26. 2018 Yin-Wen Lee,Wei-Chun HuangFu,Yen-Yin Li,I-Chou Wu,Sheng-Lung Huang,Shien-Kuei Liaw, Mark Dubinskii. Distributed and side-pumped fiber laser using a laser diode bar stack . IEEE Access .2018 ;(6):70456-70462

27. 2018 Tony Eight Lin,Wei-Chun HuangFu,Min-Wu Chao,Tzu-Ying Sung,Chao-Di Chang,Yi-Ying Chen, Jui-Hua Hsieh, Huang-Ju Tu, Han-Li Huang, Shiow-Lin Pan, Kai-Cheng Hsu. A novel selective JAK2 inhibitor identified using pharmacological interactions . Frontiers in Pharmacology .2018 ;(9):1-14

28. 2017 Liu YM ,HuangFu WC ,Huang HL ,Wu WC ,Chen YL ,Yen Y, Huang HL, Nien CY, Lai MJ, Pan SL, Liou JP. 1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma . European Journal of Medicinal Chemistry .2017 ;(140):84-91

29. 2017 Hsu KC ,Hung HC ,HuangFu WC ,Sung TY ,Lin ET ,Fang MY, Chen IJ, Pathak N, Hsu JT, Yang JM. Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains . Scientific Reports .2017 ;(7)

30. 2017 Ming-Kang Lee,Shau-Ping Lin,Wei-Chun HuangFu,Dee-Shiuh Yang,I-Hsuan Liu. Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells . PLoS One .2017 ;(12):e0184111

31. 2017 Hsueh-Yun Lee,Jiann-Fong Lee,Sunil Kumar,Yi-Wen Wu,Wei-Chun HuangFu,Lai MJ, Li YH, Huang HL, Kuo FC, Hsiao CJ, Cheng CC, Yang CR, Liou JP. 3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity . European Journal of Medicinal Chemistry .2017 ;(125):1268-1278

32. 2017 HuangFu WC,Chao MW,Cheng CC,Wei YC,Wu YW,Liou JP, Hsiao G, Lee YC, Yang CR. Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo . Sci Rep .2017 ;(7):1-12

33. 2017 Chao MW,Huang HL,HuangFu WC,Hsu KC,Liu YM,Wu YW, Lin CF, Chen YL, Lai MJ, Lee HY, Liou JP, Teng CM, Yang CR. An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells . Oncotarget .2017

34. 2016 Nai-Yun Chang,Yen-Ju Chan,Shih-Torng Ding,Yen-Hua Lee,Wei-Chun HuangFu,I-Hsuan Liu. Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis . PLoS One .2016 ;(11):e0167

35. 2015 Yu-Tang Chin,Sheng-Huei Yang,Tung-Cheng Chang,Chun A. Changou,Hsuan-Yu Lai,Earl Fu, Wei-Chun HuangFu, Paul J. Davis, Hung-Yun Lin, Leroy F. Liu. Mechanisms of dihydrotestosterone action on resveratrol-induced anti-proliferation in breast cancer cells with different ERα status . Oncotarget .2015 ;(6):35866-35879

36. 2014 Chun-Chun Cheng,Yen-Hua Lee,Shau-Ping Lin,Wei-Chun HuangFu,I-Hsuan Liu. Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells . Journal of Biomedical Science .2014 ;(21):21

37. 2014 Chin YT,Hsieh MT,Yang SH,Tsai PW,Wang SH,Wang CC, Lee YS, Cheng GY, HuangFu WC, London D, Tang HY, Fu E, Yen Y, Liu LF, Lin HY, Davis PJ. Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro . Oncotarget .2014 ;(5):12891-12907

38. 2013 Bhattacharya S,HuangFu WC,Dong G,Qian J,Baker DP,Karar J, Koumenis C, Diehl JA, and Fuchs SY. Anti-tumorigenic effects of Type I interferon are subdued by integrated stress responses. . Oncogene .2013 ;(32):4214-4221

39. 2012 HuangFu WC,Qian J,Liu C,Liu J,Lokshin AE,Baker DP, Rui H, and Fuchs SY. Inflammatory signaling compromises cell responses to interferon alpha. . Oncogene .2012 ;(31):161-172

40. 2011 Qian J,Zheng H,HuangFu WC,Liu J,Carbone CJ,Leu NA, Baker DP, and Fuchs SY. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. . PLoS Pathogens .2011 ;(7)

41. 2010 Huangfu WC,Fuchs SY. Ubiquitination-dependent regulation of signaling receptors in cancer . Genes Cancer .2010 ;(1):725-734

42. 2010 HuangFu WC,Qian J,Liu C,Rui H,Fuchs SY. Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling. . Pigment Cell & Melanoma Research .2010 ;(23):838-840

43. 2010 Bhattacharya S,HuangFu WC,Liu J,Veeranki S,Baker DP,Koumenis C, Diehl JA, Fuchs SY.. Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. . Journal of biological chemistry .2010 ;(285):2318-2325

44. 2009 Liu J,HuangFu WC,Kumar KG,Qian J,Casey JP,Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, and Fuchs SY. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. . Cell Host Microbe .2009 ;(5):72-83

45. 2008 HuangFu WC,Liu J,Harty RN,Fuchs SY.. Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor. . FEBS letters .2008 ;(582):3206-3210

46. 2007 HuangFu WC,Matsumoto K,Ninomiya-Tsuji J.. Osmotic stress blocks NF-kappaB-dependent inflammatory responses by inhibiting ubiquitination of IkappaB. . FEBS Letters .2007 ;(281):5549-5554

47. 2006 Huangfu WC,Omori E,Akira S,Matsumoto K,Ninomiya-Tsuji J. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. . J Biol Chem .2006 ;(281):28802-28810

48. 2005 Cheng CC,Hung KC,Huang-Fu WC. Differentiate RNA Single-Stranded Region of the Branched Structures and Hairpin Loops by an Octahedral Cobalt(II) Complex . Journal of the Chinese Chemical Society .2005 ;(52):1291-1297

49. 2003 Cheng CC,Huang-Fu WC,Hung KC,Chen PJ,Wang WJ,Chen YJ. Mechanistic aspects of CoII(HAPP)(TFA)2 in DNA bulge-specific recognition. . Nucleic acids research .2003 ;(31):2227-2233

研究計畫

計畫名稱
113 新穎性DYRK1B抑制劑用於胰臟癌之藥理機轉探討與藥物研發(3/3)
補助單位
國家科學及技術委員會

計畫名稱
112 研發新穎性 HGK 抑制劑在胰臟癌中之抗 癌效用與機轉探討
補助單位
國家科學及技術委員會

計畫名稱
112 新穎性DYRK1B抑制劑用於胰臟癌之藥理機轉探討與藥物研發(2/3)
補助單位
國家科學及技術委員會

計畫名稱
111 探討新穎TBK1抑制劑對特發性肺纖維化之功效及機轉
補助單位
國家科學及技術委員會

計畫名稱
111 研發新穎性MAPK8抑制劑用於阿茲海默症治療
補助單位
國家科學及技術委員會

計畫名稱
111 新穎性DYRK1B抑制劑用於胰臟癌之藥理機轉探討與藥物研發(1/3)
補助單位
國家科學及技術委員會

計畫名稱
111 高效率掺銩鎖模光纖雷射放大器與其在生醫材料加工之應用
補助單位
臺北醫學大學

計畫名稱
110 新穎性DYRK1A抑制劑於阿茲海默症之機轉探討(3/3)
補助單位
國家科學及技術委員會

計畫名稱
109 探討利用類黃酮作為新穎DYRK1B抑制劑在惡性胰臟癌之療效
補助單位
科技部

計畫名稱
109 新穎性DYRK1A抑制劑於阿茲海默症之機轉探討(2/3)
補助單位
科技部

計畫名稱
108 新穎性DYRK1A抑制劑於阿茲海默症之機轉探討(1/3)
補助單位
科技部

計畫名稱
107 開發新穎性DYRK1A抑制劑應用於阿茲海默症之治療
補助單位
科技部

計畫名稱
105 探討新穎性雙重標靶藥物 HDACs/microtubule 抑制劑 21-277 抑制體外與體內人類腫瘤細胞生長之藥理機制
補助單位

計畫名稱
104 高功率奈米製程之摻鉺光纖雷射在皮膚分段光熱分解療法之應用
補助單位
臺北科技大學

計畫名稱
102 TMU102-AE1-B29
補助單位
臺北醫學大學新聘教師計畫