| 1. |
2024
Tze-Sian Chan,Li-Hsin Cheng,Chung-Chi Hsu,Pei-Ming Yang,Tai-Yan Liao,Hsiao-Yen Hsieh, Pei-Chun Lin, Wei-Chun HuangFu, Chih-Pin Chuu, Kelvin K. Tsai.
ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
. Molecular Oncology
.2024
;(18):562-579
|
|
| 2. |
2024
Tony Eight Lin,Dyan Yen,Wei-Chun HuangFu,Yi-Wen Wu,Jui-Yi Hsu,Shih-Chung Yen, Tzu-Ying Sung, Jui-Hua Hsieh, Shiow-Lin Pan, Chia-Ron Yang, Wei-Jan Huang, Kai-Cheng Hsu.
An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors
. Protein Science
.2024
;(33):1-15
|
|
| 3. |
2024
Sushree Shankar Panda,Chi-Chiu Lee,Khamushavalli Geevimaan,Kai-Chi Chen,Shung-Haur Yang,Chia-Ning Shen, Wei-Chun HuangFu, Han-Chung Wu .
Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression
. J Biomed Sci
.2024
;(31)
|
|
| 4. |
2023
Huang-Ju Tu,Chih-Jou Su,Chao-Shiang Peng,Tony Eight Lin,Wei-Chun HuangFu,Kai-Cheng Hsu, Tsong-Long Hwang, Shiow-Lin Pan.
Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity
. J Food Drug Anal
.2023
;(31):358-370
|
|
| 5. |
2023
Chen-Wei Chiang,Yun-Shih Lin,Fu-Ling Chang,Tsai-Yu Lin,Keng-Chang Tsai,Wei-Chun HuangFu, Yu-Ching Lee.
Single-chain fragment antibody disrupting the EphA4 function as a therapeutic drug for gastric cancer
. Biochemical and Biophysical Research Communications
.2023
;(680):161-170
|
|
| 6. |
2023
Yi-Wen Wu,Wei-Chun HuangFu,Tony Eight Lin,Chao-Hsiang Peng,Huang-Ju Tu,Ting-Yi Sung, Tzu-Ying Sung, Shih-Chung Yen, Shiow-Lin Pan, Kai-Cheng Hsu.
Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
. International Journal of Biological Macromolecules
.2023
;(259):1-13
|
|
| 7. |
2022
Tony Eight Lin, Min-Wu Chao,Wei-Chun HuangFu,Huang-JuTu, Zhao-Xiang Peng,Chih-Jou Su, Tzu-Ying Sung, Jui-Hua Hsieh, Cheng-Chung Lee, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu.
Identification and analysis of a selective DYRK1A inhibitor
. Biomedicine & Pharmacotherapy
.2022
;(146):1-12
|
|
| 8. |
2022
Shih-Chung Yen,Liang-Chieh Chen,Han-Li Huang,Wei-Chun HuangFu,Yi-Ying Chen,Tony Eight Lin, Ssu-Ting Lien, Hui-Ju Tseng, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Shiow-Lin Pan, Kai-Cheng Hsu .
Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach
. Bioorganic Chemistry
.2022
;(121):1-14
|
|
| 9. |
2022
Shih-Chung Yen,Yi-Wen Wu,Cheng-Chiao Huang,Min-Wu Chao,Huang-Ju Tu,Liang-Chieh Chen, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Jung-Chun Chu, Wei-Jan Huang, Chia-Ron Yang, Wei-Chun HuangFu, Shiow-Lin Pan, Kai-Cheng Hsu .
O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia
. Phytomedicine
.2022
;(100):1-12
|
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| 10. |
2021
Min-Wu Chao,Tony Eight Lin,Wei-Chun HuangFu,Chao-Di Chang,Huang-Ju Tu,Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu.
Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach
. J Enzyme Inhib Med Chem
.2021
;(36):98-108
|
|
| 11. |
2021
Ting-Yi Sung,Han-Li Huang,Chun-Chun Cheng,Fu-Ling Chang,Po-Li Wei,Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu, Shiow-Lin Pan.
EGFL6 promotes colorectal cancer cell growth and mobility and the anti‐cancer property of anti-EGFL6 antibody
. Cell & Bioscience
.2021
;(11):1-14
|
|
| 12. |
2021
Yi-Wen Wu,Min-Wu Chao,Huang-Ju Tu,Liang-Chieh Chen,Kai-Cheng Hsu,Jing-Ping Liou, Chia-Ron Yang, Shih-Chung Yen, Wei-Chun HuangFu, Shiow-Lin Pan.
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo
. Oncogenesis
.2021
;(10):1-14
|
|
| 13. |
2020
Chiu, Po-Yu,HuangFu, Wei-Chun,Liu, I-Hsuan,Chang, Ya-Pei.
Topical application of Heparanase-1 facilitates bone remodeling during the healing of bone defects in a mouse model
. Journal of the Chinese Medical Association
.2020
|
|
| 14. |
2020
Yen-Tzu Tseng,Chun-Lin Ko,Chia-Teng Chang,Yen-Hua Lee,Wei-Chun Huang Fu,I-Hsuan Liu.
Leucine-rich Repeat Containing 8A Contributes to the Expansion of Brain Ventricles in Zebrafish Embryos
. Biol Open
.2020
;(9)
|
|
| 15. |
2020
Chao-Feng Lin,Kai-Cheng Hsu,Wei-Chun HuangFu,Tony Eight Lin,Han-Li Huang,Shiow-Lin Pan.
Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
. BMC Pharmacol Toxicol
.2020
;(21)
|
|
| 16. |
2020
Yen-Hua Lee,Koichi Kawakami,Wei-Chun HuangFu,I-Hsuan Liu.
Chondroitin Sulfate Proteoglycan 4 Regulates Zebrafish Body Axis Organization via Wnt/planar Cell Polarity Pathway
. PLoS One
.2020
;(15)
|
|
| 17. |
2020
Kai-Cheng Hsu,Wei-Chun HuangFu,Tony Eight Lin,Min-Wu Chao,Tzu-Ying Sung,Yi-Ying Chen, Shiow-Lin Pan, Jih-Chin Lee, Shey-Cherng Tzou, Chung-Ming Sun, Jinn-Moon Yang.
A Site-Moiety Map and Virtual Screening Approach for Discovery of Novel 5-LOX Inhibitors
. Sci Rep
.2020
;(10):1-12
|
|
| 18. |
2020
Liang-Chieh Chen,Han-Li Huang,Wei-Chun HuangFu,Shih-Chung Yen,Sin-Ting Ngo,Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu.
Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia
. J Nat Prod
.2020
;(83):2967-2975
|
|
| 19. |
2020
Yen-Tzu Tseng,Shang-Wei Li,Wei-Chun HuangFu,Yun Yen,I-Hsuan Liu.
The single nucleotide variant at c.662A>G in human RRM2B is a loss-of-function mutation
. Mol Genet Genomic Med
.2020
;(8):e1497
|
|
| 20. |
2020
Chia-Teng Chang,Yen-Hua Lee,Wei-Chun HuangFu,I-Hsuan Liu.
Cell-intrinsic Fgf signaling contributes to primordial germ cell homing in zebrafish
. Theriogenology
.2020
;(158):424-431
|
|
| 21. |
2018
RituOjha,Han-Li Huang,Wei-Chun HuangFu, Yi-Wen Wu,Kunal Nepali,Mei-Jung Lai, Chih-Jou Su, Ting-Yi Sung, Yi-Lin Chen, Shiow-Lin Pan, Jing-Ping Liou.
1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC
. Eur J Med Chem
.2018
;(150):667-677
|
|
| 22. |
2018
Yi-Wen Wu,Kai-Cheng Hsu,Hsueh-Yun Lee,Tsui-Chin Huang,Tony E. Lin,Yi-Ling Chen, Ting-Yi Sung, Jing-Ping Liou, Wendy W. Hwang-Verslues, Shiow-Lin Pan, Wei-Chun HuangFu.
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo
. Front. Pharmacol.
.2018
;(9):1-16
|
|
| 23. |
2018
Ming‐Kai Jhan,Wei‐Chun HuangFu,Yi‐Fan Chen,Jo‐Chi Kao,Tsung‐Ting Tsai,Min‐Ru Ho, Ting‐Jing Shen, Po‐Chun Tseng, Yung‐Ting Wang, Chiou‐Feng Lin.
Anti‐TNF‐α restricts dengue virus‐induced neuropathy
. Journal of Leukocyte Biology
.2018
;(104):961-968
|
|
| 24. |
2018
Jo-Chi Kao,Wei-Chun HuangFu,Tsung-Ting Tsai,Min-Ru Ho,Ming-Kai Jhan,Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Chiou-Feng Lin.
The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR
. PLoS Neglected Tropical Diseases
.2018
;(12):1-16
|
|
| 25. |
2018
Quan-Liang Jian,Wei-Chun HuangFu,Yen-Hua Lee,I-Hsuan Liu.
Age but not short-term intensive swimming affects chondrocyte turnover in zebrafish vertebral cartilage
. PeerJ
.2018
;(6):1-23
|
|
| 26. |
2018
Yin-Wen Lee,Wei-Chun HuangFu,Yen-Yin Li,I-Chou Wu,Sheng-Lung Huang,Shien-Kuei Liaw, Mark Dubinskii.
Distributed and side-pumped fiber laser using a laser diode bar stack
. IEEE Access
.2018
;(6):70456-70462
|
|
| 27. |
2018
Tony Eight Lin,Wei-Chun HuangFu,Min-Wu Chao,Tzu-Ying Sung,Chao-Di Chang,Yi-Ying Chen, Jui-Hua Hsieh, Huang-Ju Tu, Han-Li Huang, Shiow-Lin Pan, Kai-Cheng Hsu.
A novel selective JAK2 inhibitor identified using pharmacological interactions
. Frontiers in Pharmacology
.2018
;(9):1-14
|
|
| 28. |
2017
Liu YM ,HuangFu WC ,Huang HL ,Wu WC ,Chen YL ,Yen Y, Huang HL, Nien CY, Lai MJ, Pan SL, Liou JP.
1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma
. European Journal of Medicinal Chemistry
.2017
;(140):84-91
|
|
| 29. |
2017
Hsu KC ,Hung HC ,HuangFu WC ,Sung TY ,Lin ET ,Fang MY, Chen IJ, Pathak N, Hsu JT, Yang JM.
Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains
. Scientific Reports
.2017
;(7)
|
|
| 30. |
2017
Ming-Kang Lee,Shau-Ping Lin,Wei-Chun HuangFu,Dee-Shiuh Yang,I-Hsuan Liu.
Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells
. PLoS One
.2017
;(12):e0184111
|
|
| 31. |
2017
Hsueh-Yun Lee,Jiann-Fong Lee,Sunil Kumar,Yi-Wen Wu,Wei-Chun HuangFu,Lai MJ, Li YH, Huang HL, Kuo FC, Hsiao CJ, Cheng CC, Yang CR, Liou JP.
3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity
. European Journal of Medicinal Chemistry
.2017
;(125):1268-1278
|
|
| 32. |
2017
HuangFu WC,Chao MW,Cheng CC,Wei YC,Wu YW,Liou JP, Hsiao G, Lee YC, Yang CR.
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo
. Sci Rep
.2017
;(7):1-12
|
|
| 33. |
2017
Chao MW,Huang HL,HuangFu WC,Hsu KC,Liu YM,Wu YW, Lin CF, Chen YL, Lai MJ, Lee HY, Liou JP, Teng CM, Yang CR.
An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells
. Oncotarget
.2017
|
|
| 34. |
2016
Nai-Yun Chang,Yen-Ju Chan,Shih-Torng Ding,Yen-Hua Lee,Wei-Chun HuangFu,I-Hsuan Liu.
Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis
. PLoS One
.2016
;(11):e0167
|
|
| 35. |
2015
Yu-Tang Chin,Sheng-Huei Yang,Tung-Cheng Chang,Chun A. Changou,Hsuan-Yu Lai,Earl Fu, Wei-Chun HuangFu, Paul J. Davis, Hung-Yun Lin, Leroy F. Liu.
Mechanisms of dihydrotestosterone action on resveratrol-induced anti-proliferation in breast cancer cells with different ERα status
. Oncotarget
.2015
;(6):35866-35879
|
|
| 36. |
2014
Chun-Chun Cheng,Yen-Hua Lee,Shau-Ping Lin,Wei-Chun HuangFu,I-Hsuan Liu.
Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells
. Journal of Biomedical Science
.2014
;(21):21
|
|
| 37. |
2014
Chin YT,Hsieh MT,Yang SH,Tsai PW,Wang SH,Wang CC, Lee YS, Cheng GY, HuangFu WC, London D, Tang HY, Fu E, Yen Y, Liu LF, Lin HY, Davis PJ.
Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro
. Oncotarget
.2014
;(5):12891-12907
|
|
| 38. |
2013
Bhattacharya S,HuangFu WC,Dong G,Qian J,Baker DP,Karar J, Koumenis C, Diehl JA, and Fuchs SY.
Anti-tumorigenic effects of Type I interferon are subdued by integrated stress responses.
. Oncogene
.2013
;(32):4214-4221
|
|
| 39. |
2012
HuangFu WC,Qian J,Liu C,Liu J,Lokshin AE,Baker DP, Rui H, and Fuchs SY.
Inflammatory signaling compromises cell responses to interferon alpha.
. Oncogene
.2012
;(31):161-172
|
|
| 40. |
2011
Qian J,Zheng H,HuangFu WC,Liu J,Carbone CJ,Leu NA, Baker DP, and Fuchs SY.
Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1.
. PLoS Pathogens
.2011
;(7)
|
|
| 41. |
2010
Huangfu WC,Fuchs SY.
Ubiquitination-dependent regulation of signaling receptors in cancer
. Genes Cancer
.2010
;(1):725-734
|
|
| 42. |
2010
HuangFu WC,Qian J,Liu C,Rui H,Fuchs SY.
Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling.
. Pigment Cell & Melanoma Research
.2010
;(23):838-840
|
|
| 43. |
2010
Bhattacharya S,HuangFu WC,Liu J,Veeranki S,Baker DP,Koumenis C, Diehl JA, Fuchs SY..
Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor.
. Journal of biological chemistry
.2010
;(285):2318-2325
|
|
| 44. |
2009
Liu J,HuangFu WC,Kumar KG,Qian J,Casey JP,Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, and Fuchs SY.
Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor.
. Cell Host Microbe
.2009
;(5):72-83
|
|
| 45. |
2008
HuangFu WC,Liu J,Harty RN,Fuchs SY..
Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor.
. FEBS letters
.2008
;(582):3206-3210
|
|
| 46. |
2007
HuangFu WC,Matsumoto K,Ninomiya-Tsuji J..
Osmotic stress blocks NF-kappaB-dependent inflammatory responses by inhibiting ubiquitination of IkappaB.
. FEBS Letters
.2007
;(281):5549-5554
|
|
| 47. |
2006
Huangfu WC,Omori E,Akira S,Matsumoto K,Ninomiya-Tsuji J.
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
. J Biol Chem
.2006
;(281):28802-28810
|
|
| 48. |
2005
Cheng CC,Hung KC,Huang-Fu WC.
Differentiate RNA Single-Stranded Region of the Branched Structures and Hairpin Loops by an Octahedral Cobalt(II) Complex
. Journal of the Chinese Chemical Society
.2005
;(52):1291-1297
|
|
| 49. |
2003
Cheng CC,Huang-Fu WC,Hung KC,Chen PJ,Wang WJ,Chen YJ.
Mechanistic aspects of CoII(HAPP)(TFA)2 in DNA bulge-specific recognition.
. Nucleic acids research
.2003
;(31):2227-2233
|
|