陳凱筠(Chen, Kai-Yun) 教授

Email
kychen08@tmu.edu.tw
現   職
神經醫學博士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國防醫學院生命科學研究所 博士
1997/09~2004/02
國防醫學院微生物及免疫學研究所 碩士
1994/09~1996/06
高雄醫學院醫事技術學系 學士
1989/09~1992/06

本校學術經歷

任職單位與職稱[起迄時間]
神經醫學博士學位學程教授
2022/08/01~
(舊)神經再生醫學博士學位學程副教授
2019/02/01~2022/07/31
(舊)神經再生醫學博士學位學程助理教授
2013/08/01~2019/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
臺北醫學大學博士後研究
2008/08/01~2013/07/31

專長與研究領域

學門領域
幹細胞/再生生物醫學
生物學之生化及分子生物
醫學之生化及分子生物
轉譯醫學專案研究計畫
微生物及免疫學
學術專長

論文著作

清冊下載


1. 2023 Lin TC,Tsai YC,Chen YA,Young TH,Wu CC,Chiang YH, Kao CH, Huang A PH, Hsu YH, Chen KY, Tsai LK . Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study . Frontiers in Cellular Neuroscience .2023

2. 2023 Chan Lung,Hsu Wayne,Chen Kai Yun,Wang Weu,Hung Yi Chieh,Hong Chien Tai,Chan Lung,Hsu Wayne,Chen Kai Yun,Wang Weu,Hung Yi Chieh,Hong Chien Tai. Therapeutic Effect of Human Adipocyte-derived Stem Cell-derived Exosomes on a Transgenic Mouse Model of Parkinson's Disease . In vivo (Athens, Greece) .2023 ;(37):2028-2038

3. 2023 Tsou Yi Syue,Lai Jing Huei,Chen Kai Yun,Chang Cheng Fu,Huang Chi Chen,Tsou Yi Syue,Lai Jing Huei,Chen Kai Yun,Chang Cheng Fu,Huang Chi Chen. Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke . International journal of molecular sciences .2023 ;(24)

4. 2023 Phuong Thao Do,De‑Maw Chuang,Chung‑Che Wu,Chi‑Zong Huang,Yen‑Hua Chen,Shuo‑Jhen Kang, Yung‑Hsiao Chiang, Chaur‑Jong Hu, Kai‑Yun Chen. Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood‑Brain Barrier Integrity in Experimental Ischemic Stroke . Translational Stroke Research .2023

5. 2022 Tsai Yan Rou,Kim Dong Seok,Hsueh Shih Chang,Chen Kai Yun,Wu John Chung Che,Wang Jia Yi,Tsou Yi Syue,Hwang Inho,Kim Yukyung,Gil Dayeon,Jo Eui Jung,Han Baek Soo,Tweedie David,Lecca Daniela,Scerba Michael T.,Selman Warren R.,Hoffer Barry J.,Greig Nigel H.,Chiang Yung Hsiao,Tsai Yan Rou,Kim Dong Seok,Hsueh Shih Chang,Chen Kai Yun,Wu John Chung Che,Wang Jia Yi,Tsou Yi Syue,Hwang Inho,Kim Yukyung,Gil Dayeon,Jo Eui Jung,Han Baek Soo,Tweedie David,Lecca Daniela,Scerba Michael T.,Selman Warren R.,Hoffer Barry J.,Greig Nigel H.,Chiang Yung Hsiao. 3,6′‐ and 1,6′‐Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation . Pharmaceutics .2022 ;(14)

6. 2022 Chien-Tai Hong,Lung Chan,Kai-Yun Chen,Hsun-Hua Lee,Li-Kai Huang,Yu-Chen S. H. Yang, Yun-Ru Liu, Chaur-Jong Hu. Rifaximin Modifies Gut Microbiota and Attenuates Inflammation in Parkinson’s Disease: Preclinical and Clinical Studies . Cells .2022

7. 2021 Do PT ,Wu CC,Chiang YH,Hu CJ,Chen KY. Mesenchymal stem/stromal cell therapy in blood-brain barrier preservation following ischemia: Molecular mechanisms and prospects . International Journal of Molecular Sciences .2021 ;(22)

8. 2021 Lo YC,Chen KY ,Chou HC,Lin IH,Chen CM . Neonatal hyperoxia induces gut dysbiosis and behavioral changes in adolescent mice . Journal of the Chinese Medical Association .2021 ;(84):290-298

9. 2021 Ma HP+,Ou JC+,Chen KY,Liao KH,Kang SJ,Wang JY, Chiang YH,Wu JC. Screening for Poor Self-Reported Sleep Quality at 12 Weeks in Post-Mild Traumatic Brain Injury Patients Using the HF-Age-Gender (HAG) Index . Brain Sci . .2021

10. 2021 Chen KY,Tsai TY,Chang CF,Ou JC,Tsai YR,Ma HP, Chiu WT, Tsai SH, Liao KH, Lin JW, Lin CM, Wu JCC, Chiang YH. Worsening of Dizziness Impairment Is Associated with Bone Marrow Kinase on Chromosome X Level in Patients after Mild Traumatic Brain Injury . Journal of Neurotrauma .2021

11. 2020 Hong CT,Chen KY,Wang W,Chiu JY,We D,Chao TY, Hu CJ, Chau KYD, Bamodu OA. Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling . Cells .2020 ;(9):740

12. 2020 Feng XJ,Huang YT ,Huang YZ,Kuo CW,Peng CW,Rotenberg A, Juan CH, Pei YC, Chen YH, Chen KY, Chiang YH, Liu HH, Wu JX, Hsieh TH. Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-induced Parkinsonism in rats . Brain Stimulation .2020 ;(13):655-663

13. 2020 Ali AAA,Shahror RA ,Chen KY. Efficient labeling of mesenchymal stem cells for high sensitivity long-term MRI monitoring in live mice brains . International Journal of Nanomedicine .2020 ;(15):97-114

14. 2020 Shahror RA,Wu CC,Chiang YH,Chen KY,Shahror RA,Wu CC, Chiang YH, Chen KY. Genetically modified mesenchymal stem cells: The next generation of stem cell-based therapy for TBI . International Journal of Molecular Sciences .2020 ;(21):1-17

15. 2020 Chi NF ,Chiou HY ,Chou SY ,Hu CJ ,Chen KY ,Chang CF, Hsieh YC . Hyperglycemia-related FAS gene and hsa-let-7b-5p as markers of poor outcomes for ischaemic stroke . European Journal of Neurology .2020 ;(27):1647-1655

16. 2020 Leung SW ,Lai JH ,Wu John CC,Tsai YR,Chen YH,Kang SJ,Chiang YH,Chang CF, Chen KY. Neuroprotective effects of emodin against ischemia/reperfusion injury through activating erk-1/2 signaling pathway . International Journal of Molecular Sciences .2020 ;(21)

17. 2020 Hsieh TH,Kuo CW ,Hsieh KH,Shieh MJ,Peng CW,Chen YC, Chang YL,Huang YZ, Chen CC, Chang PK, Chen KY, Chen HY. Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson's disease . Brain Sciences .2020 ;(10)

18. 2019 Lee HH,Ma HP,Ou JC,Ong JR,Chen KY,Wu CC, Chiu WT, Liao KH, Lin CM, Lin SY, Wu D, Huang YH, Wang YH, Hu CJ, Hong, CT. Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury . Frontiers in Neurology .2019

19. 2019 Ma HP,Chen PS,Wong CS,Chang CF,Ou JC,Tsai YR, Chiu WT, Tsai SH, Liao KH, Chiang YH,Wang JY, Chen KY*, Wu JC*. Psychometric Evaluation of Anxiety, Depression, and Sleep Quality after a Mild Traumatic Brain Injury: A Longitudinal Study . Behavioural Neurology .2019 ;(2019)

20. 2019 Shahror RA,Linares GR,Wang Y,Hsueh SC,Wu CC,Chuang DM, Chiang YH, Chen KY. Transplantation of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury . JOURNAL OF NEUROTRAUMA .2019

21. 2019 Lai JH,Chen KY,Wu JC,Olson L,Brené S,Huang CZ, Chen YH, Kang SJ, Ma KH, Hoffer BJ, Hsieh TH, Chiang YH. Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease. . Brain Res. .2019

22. 2019 Shahror RA,Ali AAA,Wu CC,Chiang YH,Chen KY. Enhanced Homing of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 to Injury Site in a Mouse Model of Traumatic Brain Injury. . Int J Mol Sci. .2019 ;(20):E2624

23. 2019 Tsai YR,Tweedie D,Navas-Enamorado I, Scerba MT,Chang CF,Lai JH, Wu JC, Chen YH, Kang SJ, Hoffer BJ, de Cabo R, Greig NH, Chiang YH, Chen KY.. Pomalidomide Reduces Ischemic Brain Injury in Rodents. . Cell Transplant. .2019 ;(28):439-450

24. 2019 Shahror RA,Wu CC,Chiang YH,Chen KY. Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model . JOVE .2019

25. 2019 Wang YJ,Wong HS,Wu CC,Chiang YH,Chiu WT, Chen KY, Chang WC.. The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury. . J Biomed Sci. .2019 ;(26):94

26. 2019 Wang YJ ,Chang WC,Wu CC,Chiang YH,Chiu WT,Chen KY, Chang WP. Increased short- and long-term risk of sleep disorders in people with traumatic brain injury . Neuropsychological Rehabilitation .2019

27. 2019 Hsieh YL, Su FY,Tsai LK,Huang CC,Ko YL,Su LW, Chen KY, Shih HM, Hu CM, Lee WH.. NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase. . Cell Rep. .2019 ;(29):2134-2143

28. 2019 Tsai WL,Chen HY,Huang YZ,Chen YH,Kuo CW,Chen KY, Hsieh TH.. Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson's Disease. . Behav Neurol. .2019 ;(2019):4829572

29. 2018 Wang Yu Jia ,Chen Kai Yun ,Kuo Li Na ,Wang Wen Chang ,Hsu Yu Wen . The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury . BMC Medical Genetics .2018 ;(19)

30. 2018 Yu YW ,Hsueh SC,Lai JH,Chen YH,Kang SJ,Chen KY, Hsieh TH, Hoffer BJ, Li Y, Greig NH, Chiang YH.. Glucose-dependent insulinotropic polypeptide mitigates 6-OHDA-induced behavioral impairments in Parkinsonian rats . International Journal of Molecular Sciences .2018 ;(19)

31. 2018 Hsieh Tsung Hsun ,Peng Chih Wei ,Chen Kai Yun ,Huang Ying Zu ,Lin Yi Huang , Wei Zong Zhong, Jen I. Liang, Jingpu Zhao, Chun Yu Cheng, Ya Ju Chang, Chih Hsiu Cheng, Yu Fen Chuang. The applications of smart mobile device for detecting balance dysfunction in individuals with down syndrome . Biomedical Engineering - Applications, Basis and Communications .2018 ;(30)

32. 2018 Hsueh Shih Chang ,Chen Kai Yun ,Lai Jing Huei ,Wu Chung Che ,Yu Yu Wen . Voluntary physical exercise improves subsequent motor and cognitive impairments in a rat model of parkinson’s disease . International Journal of Molecular Sciences .2018 ;(19)

33. 2018 Chang Chih Ju ,Chang Ming Yuan ,Lee Yi Chao ,Chen Kai Yun ,Hsu Tsung I. . Nck2 is essential for limb trajectory selection by spinal motor axons . Developmental Dynamics .2018 ;(247):1043-1056

34. 2018 Lai JH,Karlsson TE,Wu JC,Huang CZ,Chen YH,Kang SJ,Brodin ATS, Hoffer BJ,Olson L, Chiang YH, Chen KY. Role of Nogo receptor-1 for recovery of balance, cognition andemotion after mild traumatic brain injury in mice . Journal of Neurotrauma .2018

35. 2018 Tsai Yan Rou ,Chang Cheng Fu ,Lai Jing Huei ,Wu John Chung Che ,Chen Yen Hua , Kang SJ, Hoffer BJ, Tweedie D, Luo W, Greig NH, Chiang YH, Chen KY.. Pomalidomide ameliorates H2O2-induced oxidative stress injury and cell death in rat primary cortical neuronal cultures by inducing anti-oxidative and anti-apoptosis effects . International Journal of Molecular Sciences .2018 ;(19)

36. 2017 Ma HP,Chen PS,Ou JC,Chiang YH,Tsai SH,Chiu WT, Liao KH, Wu CC, Chen KY. Significance of Balance Test in Assessing Emotional Aspect of Dizziness in Mild Traumatic Brain Injury Patients . JOURNAL OF NEUROLOGY AND NEUROSCIENCE .2017 ;(8):1-7

37. 2017 Chang KY,Hsu TI,Hsu CC,Tsai SY ,Liu JJ,Chou SW, Liu MS, Liou JP, Ko CY,Chen KY, Hung JJ, Chang WC, Chuang CK, Kao TJ, Chuang JY. Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase . Redox Biology .2017 ;(13):655-664

38. 2017 Lee KH,Chen CL ,Lee YC,Kao TJ,Chen KY,Fang CY, Chang WC, Chiang YH, Huang . Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway . Scientific Reports .2017 ;(7)

39. 2017 Lee HH ,Yeh CT ,Ou JC ,Ma HP ,Chen KY ,Chang CF, Lai JH, Liao KH, Lin CM, Lin SY, Wu D, Huang YH, Hu CJ, Hong CT.. The association of Apolipoprotein E allele 4 polymorphism with the recovery of sleep disturbance after mild traumatic brain injury . Acta Neurologica Taiwanica .2017 ;(26):13-19

40. 2017 Chang CF,Lai JH,Wu JC,Greig NH,Becker RE,Luo Yu, Chen YH, Kang SJ, Chiang YH, Chen KY. (−)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury . Brain Research .2017 ;(1677):118-128

41. 2017 Hsieh TH,Kang JW ,Lai JH ,Huang YZ ,Rotenberg A,Chen KY, Wang JY, Chan SY, Chen SC, Chiang YH, Peng CW.. Relationship of mechanical impact magnitude to neurologic dysfunction severity in a rat traumatic brain injury model . PLoS One .2017 ;(12)

42. 2017 Kai-Yun Chen,Shih-Wei Huang,Yen-Nung Lin,Chun-De Liao,Wen-Hsuan Hou,Tsan-Hon Liou, Yung-Hsiao Chiang, Shin-Han Tsa, Wen-Ta Chiu, Li-Fong Lin.. Postural Stability Assessment in Patients with Mild Traumatic Brain Injury Complaining of Dizziness . Journal of Medical and Biological Engineering .2017

43. 2016 Yu YW,Hsieh TH,Chen KY,Wu J. CC,Hoffer J. B,Greig H. N, Li Y, Lai JH, Chang CF, Lin JW, Chen YH, Yang LY, Chiang YH. Glucose-dependent insulinotropic polypeptide Ameliorates mTBI-induced Cognitive and Sensorimotor Deficits in Rats . J Neurotrauma .2016

44. 2016 Wong YH,Wu CC,Wu JC,Lai HY,Chen KY,Jheng BR, Chen MC, Chang TH, Chen BS. Temporal Genetic Modifications after Controlled Cortical Impact-Understanding Traumatic Brain Injury through a Systematic Network Approach . International Journal of Molecular Sciences .2016

45. 2016 Liao Kuo-Hsing ,Sung Chih-Wei ,Chu Shu-Fen ,Chiu Wen-Ta ,Chiang Yung-Hsiao . Reduced power spectra of heart rate variability are correlated with anxiety in patients with mild traumatic brain injury . Psychiatry Research .2016 ;(243):349-56

46. 2015 Sung CW,Chen KY,Chiang YH,Chiu WT,Ou JC,Lee HC, Tsai SH, Lin JW, Yang CM, Tsai YR, Liao KH, Chen GS, Li WJ, Wang JY. Heart rate variability and serum level of insulin-like growth factor-1 are correlated with symptoms of emotional disorders in patients suffering a mild traumatic brain injury . Clinical Neurophysiology .2015

47. 2015 Liao KH,Wang JY,Lin HW,Lui TN,Chen KY,Yen DH, Jeng MJ. Risk of death in patients with post-traumatic cerebrospinal fluid leakage-Analysis of 1773 cases . J Chin Med Assoc .2015

48. 2014 Wang YJ,Hsu YW,Chang CM,Wu CC,Ou JC,Tsai YR, Chiu WT, Chang WC, Chiang YH, Chen KY. The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury . BioMed Research International .2014 ;(2014):1-7

49. 2013 Wu CC,Chen KY,Yu YW,Huang SW,Shih HM,Chiu WT, Chiang YH, Shiau CY. Different Sham Procedures Induce Corresponding Increases in Levels of Trauma Markers For Rats in Traumatic Brain Injury Experiments . J Surg Res. .2013 ;(179):138-144

50. 2012 Wu CC,Chen KY,Yu YW,Huang SW,Shih HM,Chiu WT, Chiang YH, Shiau CY. Location and Level of Etk Expression in Neurons Are Associated with Varied Severity of Traumatic Brain Injury . PLoS One .2012 ;(7):e39226

51. 2012 Chen KY,Wu CC,Chang CF,Chen YH,Chiu WT,Lou YH, Chen YH, Shih HM, Chiang YH. Suppression of Etk/Bmx Protects against Ischemic Brain Injury. . Cell Transplantation .2012 ;(21):345-354

52. 2010 Chang CJ,Hsu CC,Yung MC,Chen KY,Tzao C,Wu WF, Chou HY, Lee YY, Lu KH, Chiou SH, Ma HI. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. . Biochemical and Biophysical Research Communications .2010 ;(380):236-242

53. 2009 Lo CH,Chang CM,Tang SW,Pan WY,Fang CC,Chen Y, Wu PY, Chen KY, Ma HI, Xiao X, Tao MH. Differential antitumor effect of interleukin-12 family cytokines on orthotopic hepatocellular carcinoma. . J Gene Med .2009 ;(12):423-434

研究計畫

計畫名稱
113 探討BMX與Wnt/beta-catenin訊息傳遞路徑對腦外傷後認知功能缺失的調控機制(3/3)
補助單位
國家科學及技術委員會

計畫名稱
112 探討BMX與Wnt/beta-catenin訊息傳遞路徑對腦外傷後認知功能缺失的調控機制(2/3)
補助單位
國家科學及技術委員會

計畫名稱
111 探討BMX與Wnt/beta-catenin訊息傳遞路徑對腦外傷後認知功能缺失的調控機制(1 /3)
補助單位
國家科學及技術委員會

計畫名稱
110 闡明CEEMT(環境豐富化合併音樂療法) 對腦外傷後認知、憂鬱與焦慮的影響與機制探討
補助單位
科技部

計畫名稱
109 多功能氧化銥複合薄膜微電極合成機制之探討及於生醫電子藥物及生醫感測器之應用
補助單位
臺北醫學大學

計畫名稱
108 腦外傷後睡眠障礙的分析與治療—以音樂治療介入動物模式
補助單位
科技部

計畫名稱
108 神經再生醫學博士學位學程博士生Rami shahr君擬於108年10月19日至10月23日赴美國芝加哥參加神經科學學會第49屆年會
補助單位
科技部

計畫名稱
107 深層腦刺激併用運動治療巴金森氏症之機制探討
補助單位
科技部

計畫名稱
107 Rami shahr君擬於107年11月3日至11月7日赴美國聖地牙哥參加神經科學會第48屆年會
補助單位

計畫名稱
106 巴金森氏症之新穎療法
補助單位
科技部

計畫名稱
105 研究Etk/Bmx在大黃素對腦損傷的神經保護作用中所扮演之角色
補助單位
阮綜合醫療社團法人阮綜合醫院

計畫名稱
104 大腦皮質電刺激對於增進創傷性腦損傷動物之生理機制探討
補助單位
科技部

計畫名稱
104 利用基因體學、表觀基因體學及表觀蛋白質體學分析探討Etk/Bmx腦損傷中所扮演的角色
補助單位
科技部

計畫名稱
104 以類澱粉前驅蛋白抑制劑Phenserine治療腦中風之研究-賴璟暉
補助單位
科技部

計畫名稱
104 以類澱粉前驅蛋白抑制劑Phenserine治療腦中風之研究(3/3)
補助單位
科技部

計畫名稱
104 以類澱粉前驅蛋白抑制劑Phenserine治療腦中風之研究(3/3)
補助單位
科技部

計畫名稱
103 運動及環境豐富化引發的神經滋養與神經重塑在輕度腦外傷動物的治療效果
補助單位
科技部

計畫名稱
103 The dosage effect of PAI0l on glioblastoma cell growth PAI0l 對小鼠顱內腫瘤之生長影響
補助單位
普惠德生技股份有限公司

計畫名稱
102 TMU102-AE1-B27
補助單位
臺北醫學大學新聘教師計畫