卓爾婕(Cho, Er-Chieh) 教授

Email
echo@tmu.edu.tw
現   職
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程 主任
臨床藥學學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
牛津大學臨床藥理學所 博士
2006/09~2011/02
臺北醫學大學細胞與分子生物研究所 碩士
2003/09~2005/06
臺北醫學大學藥學系 學士
1999/09~2003/06

本校學術經歷

任職單位與職稱[起迄時間]
臨床藥學學科教授
2020/08/01~
臨床藥學學科副教授
2017/02/01~2020/07/31
臨床藥學學科助理教授
2013/05/01~2017/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
臨床基因體學暨蛋白質體學碩士學位學程主任
2021/08/01 ~ 2022/07/31
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程主任
2019/08/01 ~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程副教授
2017/02/01 ~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程
2014/08/01 ~ 2017/01/31

其它經歷

任職單位與職稱[起迄時間]
臺北醫學大學博士後研究員
2013/01~2013/04
美國希望城醫學中心博士後研究員
2011/10~2012/12
美國加州大學洛杉磯分校博士後學者
2011/01~2011/09
中央研究院碩士級研究助理
2005/07~2006/02

專長與研究領域

學門領域
藥理及毒理
醫學之生化及分子生物
藥學
生物學之生化及分子生物
學術專長

論文著作

清冊下載


1. 2024 Lin J, ,Lin JH, ,Yeh TY, ,Zheng JH, ,Cho EC*, ,Lee KC*. Fabrication of hyaluronic acid with graphene quantum dot as a dual drug delivery system for cancer therapy. . FlatChem .2024 ;(44):1-9

2. 2023 Y.-L. Chen ,G.-Y. Lee ,D.-W. Tang ,K. Huang ,P.-Y. Lo ,J.-H. Huang, E.-C. Cho, K.-C. Lee . 2-Mercaptoimidazole selectively etching and thiol-functionalized ZIF-8 metaleorganic framework to serve as a multifaceted platform for radical scavenging and Au loading . Materials Today Chemistry .2023 ;(27):1-12

3. 2023 Lee KC,Hsiao YS,Sung MY,Chen YL,Wu NJ,Huang JH, Cho EC*, Weng HC*, Hsu SC*. MOF-derived spinel NiMn2O4/CoMn2O4 heterojunction and its application in a high-performance photocatalyst and supercapacitor . Journal of Environmental Chemical Engineering .2023 ;(11):1-13

4. 2023 Cho EC,Hsiao YS,Huang JH,Sung MY,Chen YL,Wu NJ, Hsu SC*, Weng HC*, Lee KC*. Construction of BiVO4/Bi2WO6/WO3 heterojunctions with improved photocatalytic capability in elimination of dye and antibiotics and inactivation of E. coli . Journal of the Taiwan Institute of Chemical Engineers .2023 ;(149):1-11

5. 2023 Chen YL,Chen Li,Sung MY,Lin JH,Liu CJ,Kuo CJ, Cho EC*, Lee KC*. Environment-friendly organic coordination design of Z-scheme heterojunction N-BOB/BiOIO3 for efficient LED-light-driven photocatalytic and electrochemical performance . Chemosphere .2023 ;(341):1-11

6. 2022 Lee HY, ,Tang DW, ,Liu CY, ,Cho EC*.. A novel HDAC1/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation . Chem Biol Interact . .2022 ;(352):1-10

7. 2022 Lee GY, ,Lo PY, ,Cho EC, ,Zheng JH, ,Li M, ,Huang JH, Lee K C*.. Integration of PEG and PEI with graphene quantum dots to fabricate pH-responsive nanostars for colon cancer suppression in vitro and in vivo . FlatChem .2022 ;(31):1-7

8. 2022 Cho EC,,Chang-Jian CW, ,Huang JH,,Huang TY, ,Wu NJ, ,Li MT, Chen YL, Hsu SC*, Weng HC*, Lee KC* . Preparation of Ni(OH)2/CuO heterostructures for improved photocatalytic degradation of organic pollutants and microorganism . Chemosphere .2022 ;(300):1-10

9. 2022 Cho EC,,Chang-Jian CW, ,Lu CZ, ,Huang JH, ,Hsieh TH, ,Wu NJ, Lee KC*, Hsu SC* and Weng HC* . Bio-Phenolic Resin Derived Porous Carbon Materials for High-Performance Lithium-Ion Capacitor . Polymers .2022

10. 2022 Liu HH, ,Lee CH, ,Hsieh YC, ,Zheng JH, ,Liu YR, ,Chang CH, Cho EC*. Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo . Genes .2022

11. 2021 Cho EC,, Liu CY, ,Tang DW,, Lee HY. Ring size changes in the development of class I HDAC inhibitors. . J Enzyme Inhib Med Chem .2021 ;(36):1387-1401

12. 2021 Cho EC,,Chang-Jian CW, ,Wu YJ, ,Chao SH,,Huang JH,,Lee KC, Weng HC, Hsu SC. Modification of aluminum current collectors with laser-scribed graphene for enhancing the performance of lithium ion batteries . Journal of Power Sources .2021 ;(506):1-11

13. 2021 Cho EC,,Chang-Jian CW, ,Huang JH,,Wu R T,,Lu CZ,,Lee KC, Weng HC, Hsu SC. Laser scribing of Ag-decorated graphene for high-performance and flexible heaters . Journal of the Taiwan Institute of Chemical Engineers .2021 ;(119):224-231

14. 2021 Liu HH, ,Lee CH, ,Hsieh YC, ,Hsu DW, ,Cho EC.. Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis . Biochemical and Biophysical Research Communications .2021 ;(567):183-189

15. 2021 Chen YL, ,Lee GY, ,Sung MY, ,Huang JH, ,Cho EC*, ,Lee KC*.. Versatile Functionalization of P25 Conjugated ND Nanocomposites for UV-Mediated Free Radical Scavenging and Facilitates Anti- Inflammation Potential in Human Cells . ACS Applied Materials & Interfaces .2021 ;(13):39088-39099

16. 2021 Lin TE, ,Sung LC, ,Chao MW, ,Li M,, Zheng JH,, Sung TY, Hsieh JH, Yang CR, Lee HY, Cho EC*, Hsu KC*.. Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors . J Enzyme Inhib Med Chem . .2021 ;(37):226-235

17. 2020 Lo PY,Lee GY,Zheng JH,Huang JH,Cho EC,Lee KC. Intercalating pyrene with polypeptide as a novel self-assembly nano-carrier for colon cancer suppression in vitro and in vivo . Materials Science & Engineering C .2020 ;(109):1-12

18. 2020 Chen CH,Hsieh YC,Yang PM,Liu YR,Cho EC. Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer . Biochemical and Biophysical Research Communications .2020 ;(524):1003-1009

19. 2020 Wu KS,Ho DM,Jou ST,Yu AL,Tran HM,Liang ML, Chen HH, Lee YY, Chen YW, Lin SC, Chang FC, Tsai ML, Liu YL, Lee HL, Hsieh KL, Huang WC, Sung SY, Chang CC, Changou CA, Liang KH, Hsieh TH, Liu YR, Chao ME, Chen W, Chu SS, Cho EC, Wong TT. Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan . Cancers .2020 ;(12):1-24

20. 2020 Lo PY, ,Lee GY, ,Zheng JH, ,Huang JH, ,Cho EC,,Lee KC. GFP plasmid and chemoreagent conjugated with graphene quantum dots as a novel gene delivery platform for colon cancer inhibition in vitro and in vivo . ACS Applied Bio Materials .2020

21. 2020 Lee GY, ,Cho EC,,Lo PY,,Zheng JH, ,Huang JH, ,Chen YL, Lee KC. Simultaneous formation of Bi2O2(OH)(NO3)/BiOBr ultrathin hierarchical microspheres for effectively promoting visible-lightdriven photocatalytic activity in environmental remediation . Chemosphere .2020

22. 2020 Cho EC, ,Chang-Jian CW, ,Huang JH, ,Lee GY, ,Hung WH, ,Sung MY, Lee KC, Weng HC, Syu WL, Hsiao YS, Chen CP. Co2+-Doped BiOBrxCl1−x Hierarchical Microspheres Display Enhanced Visible-Light Photocatalytic Performance in the Degradation of Rhodamine B and Antibiotics and the Inactivation of E. coli . Journal of Hazardous Materials .2020 ;(402(2021)123457):1-11

23. 2020 Cho EC , ,Chang-Jian CW , ,Chou JA , ,Chung CL , ,Ho PC, ,Lee KC, Huang JH, Huang JH, Hsiao YS. MWCNT-embedded Li4Ti5O12 microspheres interfacially modified with polyaniline as ternary composites for high-performance lithium ion battery anodes . Ceramics International .2020

24. 2020 Cho EC,,Chang-Jian CW, ,Syu WL, ,Tseng HS, ,Lee KC, ,Huang JH, Hsiao YS. PEDOT-modified laser-scribed graphene films as bginder– and metallic current collector–free electrodes for large-sized supercapacitors . Applied Surface Science .2020 ;(518)

25. 2020 Cho EC, ,Chang-Jian CW, ,Huang JH, ,Chou JA, ,Syu WL, ,Chen YL, Lee KC, Hsiao YS. Phase and morphology control in the synthesis of Co3O4 nanosphere/ a-Co(OH)2 nanosheet hybrids for application in supercapacitors . Journal of the Taiwan Institute of Chemical Engineers .2020 ;(110)

26. 2019 Lee KC,,Chang-Jian CW, ,Cho EC, ,Huang JH, ,Lin WT, ,Ho BC, Chou JA, Hsiao YS.. Surface modification of Ni(OH)2 nanosheets with PEDOT:PSS for supercapacitor and bendable electrochromic applications . Solar Energy Materials and Solar Cells .2019 ;(195):1-11

27. 2019 Lee KC,Chen YL,Wang CC,Huang JH,Cho EC. Refluxed Esterification of Fullerenes Conjugated P25 TiO2 Promotes Free Radical Scavenging Capacity and Facilitates Anti-aging Potentials in Human Cells . ACS Appl. Mater. Interfaces .2019 ;(11):311-319

28. 2019 Lee KC,Lo PY, Lee GY,Zheng JH,Cho EC.. Carboxylated carbon nanomaterials in cell cycle and apoptotic cell death regulation. . Journal of Biotechnology .2019 ;(296):14-21

29. 2019 Lu HF,Hung KS,Chu HW,Wong HS,Kim J,Kim MK, Choi BY, Tai YT, Ikegawa S, Cho EC, Chang WC.. Meta-Analysis of Genome-Wide Association Studies Identifies Three Loci Associated With Stiffness Index of the Calcaneus. . J Bone Miner Res. .2019

30. 2019 Lin MH,Wang JS,Hsieh YC,Zheng JH,Cho EC. NO2 functionalized coumarin derivatives suppress cancer progression and facilitate apoptotic cell death in KRAS mutant colon cancer . Chemico-Biological Interactions .2019 ;(309):1-10

31. 2019 Hung WH,Zheng JH,Lee KC,Cho EC. Doxorubicin conjugated AuNP/biopolymer composites facilitate cell cycle regulation and exhibit superior tumor suppression potential in KRAS mutant colorectal cancer . Journal of Biotechnology .2019 ;(306):149-158

32. 2019 Cho EC,Chang-Jian CW,Lee KC,Huang JH,Ho BC,Ding YR, Hsiao YS. Spray-dried nanoporous NiO/PANI:PSS composite microspheres for high-performance asymmetric supercapacitors . Composites Part B .2019 ;(175)

33. 2018 Cho EC,Chang-Jian CW,Zheng JH,Huang JH,Lee KC,Ho BC, Hsiao YS. Microwave-assisted synthesis of TiO2/WS2 heterojunctions with enhanced photocatalytic activity . Journal of the Taiwan Institute of Chemical Engineers .2018 ;(2018):1-10

34. 2018 Yu CY,Chang WC,Zheng JH,Hung WH,Cho EC. Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer . Biochemical and Biophysical Research Communications .2018 ;(506):901-906

35. 2018 Lu HF,Wang H SC,Chen BK,Liao HT,Hsu YW,Ikegawa S, Cho EC, Hung KS, Chang WC. Integrative genomic analysis for the functional roles of ITPKC in bone mineral density . Bioscience Reports .2018

36. 2018 Cho EC,Chang-Jian CW,Lee KC,Huang JH,Ho BC,Liu RZ, Hsiao YS. Ternary Composite Based on Homogeneous Ni(OH)2 on Graphene with Ag nanoparticles as Nanospacers for Efficient Supercapacitor . Chemical Engineering Journal .2018 ;(334):2058-2067

37. 2017 Cho EC,Chang-Jian CW,Ho BC,Yu CC,Hsiao YS,Lee KC, Huang JH. The effect of wetting property on electrochromic properties offunctionalized poly(3,4-ethylenedioxythiophene) films . Dyes and Pigments .2017 ;(145):95-102

38. 2017 Chang-Jian CW,Cho EC,Yen SC,Ho BC,Lee KC,Huang JH, Hsiao YS. Facile preparation of WO3/PEDOT:PSS composite for inkjet printed electrochromic window and its performance for heat shielding . Dyes and Pigments .2017 ;(148):465-473

39. 2017 Chang-Jian CW,Cho EC,Lee KC,Huang JH,Chen PY,Ho BC, Hsiao YS. Thermally conductive polymeric composites incorporating 3D MWCNT/PEDOT:PSS scaffolds . Composites Part B .2017 ;(136):46-54

40. 2017 Cho EC,Chang-Jian CW,Chen HC,Chuang KS,Zheng JH,Hsiao YS, Lee KC, Huang JH. Robust Multifunctional Superhydrophobic Coatings with Enhanced Water/Oil Separation, Self-Cleaning,Anti-Corrosion, and Anti-biological adhesion . Chemical Engineering Journal .2017

41. 2017 Yi-Chen Hsieh,Shih-Hsin Tu,Chien-Tien Su,Er-Chieh Cho,Chih-Hsiung Wu,Mao-Chih Hsieh, Shiyng-Yu Lin, Yun-Ru Liu, Chin-Sheng Hung, Hung-Yi Chiou. A polygenic risk score for breast cancer risk in a Taiwanese population . Breast Cancer Res Treat. .2017

42. 2016 Cho EC,Yen Y. Novel regulators and molecular mechanisms of p53R2 and its disease relevance. . Biochimie .2016 ;(123):81-84

43. 2016 Hsieh YC,Cho EC,Tu SH,Wu CH,Hung CS,Hsieh MC, Su CT, Liu YR, Lee CH, Ho YS, Chiou HY. MSH2 rs2303425 Polymorphism is Associated with Early-Onset Breast Cancer in Taiwan. . Ann Surg Oncol. .2016

44. 2016 Cho EC,Huang JH,Li CP,Chang-Jian CW,Lee KC,Yu-Sheng Hsiao, Jen-Hsien Huang. Graphene-based thermoplastic composites and their application for LED thermal management . Carbon .2016 ;(102):66-73

45. 2016 Cho EC,Chang-Jian CW,Hsiao YS,Lee KC,Huang JH. Influence of the bridging atom on the electrochromic performance of a cyclopentadithiophene polymer . SolarEnergyMaterials&SolarCells .2016 ;(150):43-50

46. 2016 Yang KC,Zheng JH,Chen YL,Lee KC,Cho EC. Carboxyfullerene decorated titanium dioxid enanomaterials for reactive oxygen species scavenging activities . RSC Adv .2016 ;(6):53025-53033

47. 2016 Cho EC,Chang-Jian CW,Hsiao YS,Lee KC,Huang JH. Interfacial engineering of melamine sponges using hydrophobic TiO2 nanoparticles for effective oil/water separation. . Journal of the Taiwan Institute of Chemical Engineers. .2016 ;(67):476-483

48. 2016 Cho EC,Chang-Jian CW,Hsiao YS,Lee KC,Huang JH. Three-dimensional carbon nanotube based polymer composites for thermal management . Composites: Part A .2016 ;(90):678-686

49. 2015 Cho EC,Kuo ML,Cheng JH,Cheng YC,Hsieh YC,Liu YR, Hsieh RH, Yen Y. RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress . Mediators of Inflammation .2015 ;(2015)

50. 2015 Cho EC,Huang JH,Li CP,Chang-Jian CW,Lee KC,Huang JH. The optoelectronic properties and applications of solution-processable titanium oxide nanoparticle . Organic Electronics .2015 ;(18):126-134

51. 2015 Cho EC,Li CP,Huang JH,Lee KC,Huang JH. Three-Dimensional conductive nanocomposites based on multiwalled carbon nanotube networks and PEDOT:PSS as a flexible transparent electrode for optoelectronics . ACS Appl. Mat. Interfaces .2015 ;(7):11668-11676

52. 2015 Cho EC,Ciou JH,Zheng JH,Pan J,Hsiao YS,Lee KC, Huang JH. Fullerene C70 decorated TiO2 nanowires for visible-light-responsive photocatalyst . Appl. Surf. Sci. .2015 ;(355):536-546

53. 2015 Cho EC,Hsiao YS,Lee KC,Huang JH. Few-layer Graphene Based Sponge as a Highly Efficient, Recyclable and Selective Sorbents for Organic Solvents and Oils . RSC Adv. .2015 ;(5):53741-53748

54. 2014 Cho EC,Kuo ML,Liu X,Yang L,Hsieh YC,Wang J, Cheng Y, Yen Y. Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients . Oncotarget .2014 ;(5):4834-4844

55. 2013 Pigazzi M,Manara E,Bresolin S,Tregnago,Beghin A,Baron E, Giarin E, Cho EC, Masetti R, Rao DS, Sakamoto KM, Basso G.. MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation. . Haematologica. .2013 ;(98):602-610

56. 2012 Cho EC,Zheng S,Munro S,Liu G,Carr SM,Moehlenbrink J, Lu YC, Stimson L, Khan O, Konietzny R, McGouran J, Coutts AS, Kessler B, et al. Arginine methylation controls growth regulation by E2F-1. . EMBO J. .2012 ;(31):1785-1797

57. 2012 Sandoval S,Kraus C,Cho EC,Cho M,Bies J,Manara E, Accordi B, Landaw EM, Wolff L, Pigazzi M, Sakamoto KM.. Sox4 cooperates with CREB in myeloid transformation. . Blood. .2012 ;(120):155-165

58. 2011 Mitton B,Cho EC,Aldana-Masangkay GI,Sakamoto KM. The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies. . Leuk Lymphoma. .2011 ;(52):2057-2063

59. 2011 Cho EC,Mitton B,Sakamoto KM. CREB and leukemogenesis. . Crit Rev Oncog. .2011 ;(16):37-46

60. 2009 Durant ST,Cho EC,La Thangue NB. p53 methylation--the Arg-ument is clear. . Cell Cycle .2009 ;(8):801-802

61. 2008 Jansson M,Durant ST,Cho EC,Sheahan S,Edelmann M,Kessler B, La Thangue NB. Arginine methylation regulates the p53 response. . Nat Cell Biol .2008 ;(10):1431-1439

62. 2006 Hsiao JC,Chao CC,Young MJ,Chang YT,Cho EC,Chang W. A poxvirus host range protein, CP77, binds to a cellular protein, HMG20A, and regulates its dissociation from the vaccinia virus genome in CHO-K1 cells. . J Virol .2006 ;(80):7714-7728

研究計畫

計畫名稱
113 篩選發炎抑制劑與老藥新用NF-κB途徑抑制劑於HMGA2致癌級聯與大腸癌之治療潛力及分子作用機轉探討(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 篩選發炎抑制劑作為HMGA2過表現型大腸 癌之抗癌藥物探討
補助單位
國家科學及技術委員會

計畫名稱
112 不同類別奈米碳材料之分子調控與毒性作用探討評估
補助單位
國家科學及技術委員會

計畫名稱
112 篩選發炎抑制劑與老藥新用NF-κB途徑抑制劑於HMGA2致癌級聯與大腸癌之治療潛力及分子作用機轉探討(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 應用發炎反應抑制劑對於致癌基因 HMGA2大量表現大腸癌之合併治療研究及調控分子機轉探討
補助單位
國家科學及技術委員會

計畫名稱
110 探討HDAC/LSD1雙效抑制劑對KRAS突變及 5-FU抗藥性大腸癌細胞之治療及機轉研究
補助單位
國家科學及技術委員會

計畫名稱
110 有機/無機混成奈米複合材料發展智慧型藥物傳輸系統以治療p53失效腫瘤之探討與評估
補助單位
科技部

計畫名稱
109 探討粒線體因子C20orf7在大腸癌進程中對化療藥物抗藥性及上皮細胞間質轉化作用EMT之調控機轉及大腸癌合併治療策略研究
補助單位
科技部

計畫名稱
108 探討趨化因子CCR6於大腸癌5-FU抗藥性的調控機轉及合併治療研究
補助單位
科技部

計畫名稱
108 解析CCL20-CCR6趨化因子途徑調控上皮細胞間質轉化作用EMT而影響大腸癌抗藥性之分子機制及治療策略研究
補助單位
科技部

計畫名稱
107 以粒線體因子NDUFAF5為標的來抑制 5FU抗藥性大腸癌之聯合治療探討及調控機轉分析
補助單位
科技部

計畫名稱
107 解析多發性骨髓瘤促進因子WHSC1在KRAS突變大腸癌之調控機制及以WHSC1為標的之聯合治療研究
補助單位
科技部

計畫名稱
106 香豆素衍生物於KRAS突變大腸癌與5- fu抗藥性癌細胞之治療及機轉研究
補助單位
科技部

計畫名稱
106 以人類細胞株及小鼠模型探討新型生物黏附性奈米材料在抗老化及皮膚癌預防之應用性研究
補助單位
科技部

計畫名稱
105 碳60及碳70富勒烯複合奈米材料對皮膚癌之預防潛力研究
補助單位
科技部

計畫名稱
105 導入RAF蛋白激?抑制劑複合奈米碳材料應用於治療KRAS突變之大腸直腸癌的藥物載體研究
補助單位

計畫名稱
104 建立化療增敏劑結合奈米碳管之癌症藥物輸送系統(2/2)
補助單位
科技部

計畫名稱
104 建立化療增敏劑結合奈米碳管之癌症藥物輸送系統(2/2)
補助單位
科技部

計畫名稱
103 建立化療增敏劑結合奈米碳管之癌症藥物輸送系統(1/2)
補助單位
科技部

計畫名稱
103 建立化療增敏劑結合奈米碳管之癌症藥物輸送系統(1/2)
補助單位
科技部

計畫名稱
102 TMU102-AE1-B02
補助單位
學校