賴鴻政(Lai, Hung-Cheng) 教授

Email
hclai@tmu.edu.tw
現   職
婦產學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國防醫學院醫學科學研究所 博士
2000/08~2003/02
國防醫學院醫學系 學士
1986/08~1993/07

本校學術經歷

任職單位與職稱[起迄時間]
婦產學科教授
2013/11/01~

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際醫學研究碩士學位學程教授
2017/08/01 ~
國際醫學研究博士學位學程教授
2017/08/01 ~
(舊)細胞治療與再生醫學國際博士學位學程籌備處教授
2017/08/01 ~
婦產學科主任
2017/02/01 ~ 2023/01/31
臨床醫學研究所
2014/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
國防醫學院教授
2011/08/01~2013/10/31
國防醫學院副教授
2008/08/01~2011/07/31
國防醫學院助理教授
2005/04/01~2007/03/31

專長與研究領域

學門領域
婦產科
學術專長
DNA methylation

論文著作

清冊下載


1. 2024 Kobayashi Y,Shimada M,Tamate M,Cho HW,Zhu J,Chou HH, Kajiyama H, Okamoto A, Aoki D, Kang S, Lee JW, Kim JW, Kim JH, Lin Z, Liu J, Wu X, Lai HC, Chang TC, Lai CH, Kim YM, Enomoto T.. Current treatment strategies for ovarian cancer in the East Asian Gynecologic Oncology Trial Group (EAGOT) . J Gynecol Oncol. .2024

2. 2024 Chen LY, Chou YT,Liew PL,Chu LH,Wen KC,Lin SF,Weng YC, Wang HC, Su PH, Lai HC.. In vitro drug testing using patient-derived ovarian cancer organoids . J Ovarian Res. .2024

3. 2024 Chen LY,Shen YA,Chu LH,Su PH,Wang HC,Weng YC, Lin SF, Wen KC, Liew PL, Lai HC.. Active DNA Demethylase, TET1, Increases Oxidative Phosphorylation and Sensitizes Ovarian Cancer Stem Cells to Mitochondrial Complex I Inhibitor . Antioxidants (Basel) . .2024

4. 2023 Peng SW ,Mai-Huong T. Ngo,Kuo YC ,Teng MH ,Guo CL , Lai HC , Chang TS ,* and Huang YH . Niclosamide Revitalizes Sorafenib through Insulin-Like Growth Factor 1 Receptor (IGF-1R)/Stemness and Metabolic Changes in Hepatocellular Carcinoma. . Cancers .2023

5. 2023 Quang Anh Do ,PH Su ,CW Chen ,HC Wang ,YX Lee ,YC Weng , LY Chen, YH Hsu and HC Lai. DNA Methylation of Window of Implantation Genes in Cervical Secretions Predicts Ongoing Pregnancy in Infertility Treatment. . International Journal of Molecular Sciences .2023

6. 2023 Yi-Xuan Lee,Po-Hsuan Su,Anh Q Do,Chii-Ruei Tzeng ,Yu-Ming Hu ,Chi-Huang Chen, Chien-Wen Chen, Chi-Chun Liao, Lin-Yu Chen, Yu-Chun Weng, Hui-Chen Wang, Hung-Cheng Lai. Cervical Secretion Methylation Is Associated with the Pregnancy Outcome of Frozen-Thawed Embryo Transfer. . Int J Mol Sci .2023

7. 2022 Wen KC,Huang RL , Chen LY ,Wu TI ,Lu CH,TY Chu, YC Ou , CH Wu , ST Hsu , DC Ding , LH Chu , CW Chen , HC Chang, YS Liu, HC Wang , YC Weng , PH Su , H Lin , HC Lai*. Endometrial Cancer Detection Using a Cervical DNA Methylation Assay (MPap) in Women with Abnormal Uterine Bleeding: A Multicenter Hospital-Based Validation Study. . Cancers .2022 ;(14(17))

8. 2022 Darmawi,Chen LY ,Su PH,Liew PL ,Wang HC,Weng YC , Huang RL , Lai HC . BHLHE22 Expression Is Associated with a Proinflammatory Immune Microenvironment and Confers a Favorable Prognosis in Endometrial Cancer. . IJMS .2022

9. 2022 Chu LH ,Liao CC,Liew Pl ,Chen CW ,Su PH ,Wen KC ,Lai HC , Huang RL ,Chen LY . Epigenomic analysis reveals the KCNK9 potassium channel as a potential therapeutic target for adenomyosis . IJMS .2022

10. 2022 LY Chen, , , , , ,Huang RL ,Su PH ,Chu LH,Weng YC ,Wang HC, Lai HC ,Wen KC . Epigenomic profiling of epithelial ovarian cancer stem-cell differentiation reveals GPD1 associated immune suppressive microenvironment and poor prognosis. . IJMS .2022

11. 2021 Su PH , , , , ,,Huang RL,Lai HC,Chen LY,YC Weng,Wang CC , Wu CC . NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. . J Biomed Sci .2021

12. 2020 Lin YC,Wen KC,Sung PL, Chou YT,Liew PL,Chen LY, Huang RL, Lai HC, Chang LT. . Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report. . Journal of Ovarian Research .2020

13. 2020 Lin YC,Liao CC,Lai HC. Intraperitoneal splenosis mimics peritoneal carcinomatosis of leiomyosarcoma and ovarian cancer. . Taiwan J Obstet Gynecol .2020

14. 2020 Lin YC,Wen KC,Sung PL,Chou YT,Liew PL,Chen LY, Huang RL, Lai HC, Chang LT.. Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report. . Journal of Ovarian Research .2020

15. 2020 Lin YC,Liao CC,Lai HC. Intraperitoneal splenosis mimics peritoneal carcinomatosis of leiomyosarcoma and ovarian cancer. . Taiwan J Obstet Gynecol. .2020

16. 2019 Frank H. C. Cheng,Lin HY,Hwang TW,Chen YC,Huang RL,Chang CB ,Weiqin Yang ,Lin RI ,Lin CW ,Gary C. W. Chen, Mai SY , Jora M. J. Lin,Chuang YM , Chou JL , Kuo LW , Chin Li, Alfred S. L. Cheng, Lai HC, Wu SF , Tsai JC , Michael W. Y. Chan. E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness. . Cancer Sci. .2019 ;(113):1085-1095

17. 2019 Mase S,Shinjo K,Totani H,Katsushima K,Arakawa A,Takahashi S, Lai HC, Lin RI, Chan MWY, Sugiura-Ogasawara M, Kondo Y. ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer. . Cancer Sci. .2019 ;(110):1105-1116

18. 2019 Su PH,Hsu YW,Huang RL,Chen LY,Chao TK,Liao CC, Chen CW, Wu TI, Mao SP, Balch C, Lai HC. TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions. . Cancer Lett. .2019 ;(450):53-62

19. 2019 Chen LY,Huang RL,Chan MW,Yan PS,Huang TS,Wu RC, Suryo Rahmanto Y, Su PH, Weng YC, Chou JL, Chao TK, Wang YC, Shih IM, Lai HC. TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target. . J Pathol. .2019

20. 2019 Li SS,Ip CKM,Tang MYH,Tang MKS,Tong Y,Zhang J, Hassan AA, Mak ASC, Yung S, Chan TM, Ip PP, Lee CL, Chiu PCN, Lee LTO, Lai HC, Zeng JZ, Shum HC, Wong AST. Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. . Nat Commun. .2019

21. 2019 Chen CW,Chang HC,Huang TF,Liao CC,Huang RL,Lai HC. Transition from multiport to single-site surgery: A single institution experience in robotic supracervical hysterectomy for benign gynecological diseases. . Taiwan J Obstet Gynecol. .2019 ;(58):514-519

22. 2019 Su PH, Lai HC,Huang RL,Chen LY,Wang YC,Wu TI,Chan MWY, Liao CC, Chen CW, Lin WY, Chang CC. Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer. . Sci Rep. .2019 ;(9)

23. 2019 Liew PL ,Huang RL,Wu TI,Liao CC,Chen CW,Su PH, Wang HC, Weng YC, Lai HC*. Combined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scrapings. . Clinical Epigenetics. .2019

24. 2019 Tzu-I Wu,Rui-Lan Huang,Po-Hsuan Su,Shih-Peng Mao,Chen-Hsuan Wu,Hung-Cheng Lai. Ovarian Cancer Detection by DNA Methylation in Cervical Scrapings. . Clinical Epigenetics .2019

25. 2019 Vin Yee Chung,Tuan Zea Tan,Jieru Ye,Rui-Lan Huang,Hung-Cheng Lai, Dennis Kappei, Heike Wollmann, Ernesto Guccione, and Ruby Yun-Ju Huang. The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells. . Commun Biol. .2019

26. 2018 Chang CC, Wang HC,Liao YP,Chen YC,Weng YC,Yu MH, Lai HC*. The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings. . Journal of Gynecologic Oncology .2018 ;(29)

27. 2018 Liew PL,Huang RL,Weng YC,Fang CL ,Hui-Ming Huang T ,Lai HC*. Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors. . Int J Cancer .2018 ;(0):0-0

28. 2018 Huang RL,Chen HJ,Chen LY,Chao TK,Lin WY,Liew PL, Su PH, Weng YC, Wang YC, Liao CC, Hsu YW, Chen Wang H, Lai HC*. Epigenetic loss of heparan sulfate 3-O-sulfation sensitizes ovarian carcinoma to oncogenic signals and predicts prognosis. . Int J Cancer. .2018 ;(143(8)):1943-1953

29. 2018 Tang MKS,Yue PYK,Ip PP,Huang RL,Lai HC,Cheung ANY, Tse KY, Ngan HYS, Wong AST. Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. . Nature Communication .2018 ;(9(1))

30. 2018 Chen HJ,Huang RL,Liew PL,Su PH,Chen LY,Weng YC, Chang CC, Wang YC, Chan MW, Lai HC. GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells . Int J Cancer. .2018 ;(143(12)):3106-3119

31. 2017 Su Po Hsuan ,Hsu Yao Wen ,Huang Rui Lan ,Weng Yu Chun ,Wang Hui Chen ,Chen YC , Tsai YJ , Yuan CC, Lai HC. Methylomics of nitroxidative stress on precancerous cells reveals DNA methylation alteration at the transition from in situ to invasive cervical cancer . Oncotarget .2017 ;(8):65281-65291

32. 2017 Kocsis Adrienn ,Takács Tibor ,Jeney Csaba ,Schaff Zsuzsa ,Koiss Róbert , Járay B, Sobel G, Pap K, Székely , Ferenci T, Lai HC, Nyíri M, Benczik M. Performance of a new HPV and biomarker assay in the management of hrHPV positive women: Subanalysis of the ongoing multicenter TRACE clinical trial (n > 6,000) to evaluate POU4F3 methylation as a potential biomarker of cervical precancer and cancer . International Journal of Cancer .2017 ;(140):1119-1133

33. 2017 Deng Shan ,Wong Chris Kong Chu ,Lai Hung Cheng ,Wong Alice Sze Tsai . Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells via simultaneous inhibition of Wnt/β-catenin signaling and epithelial-to-mesenchymal transition . Oncotarget .2017 ;(8):25897-25914

34. 2017 Hsu YW ,Huang RL ,Su PH,Chen YC,Wang HC, Liao CC, Lai HC. Genotype-specific methylation of HPV in cervical intraepithelial neoplasia . Journal of Gynecologic Oncology .2017 ;(28)

35. 2017 Chao TK ,Huang TS ,Liao YP ,Huang RL ,Su PH, Shen HY, Lai HC, Wang YC. Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer . PLoS One .2017 ;(12)

36. 2017 Chang PY,Liao YP,Wang HC,Chen YC,Huang RL,Wang YC, Yuan CC, Lai HC. An epigenetic signature of adhesion molecules predicts poor prognosis of ovarian cancer patients. . Oncotarget .2017 ;(8)

37. 2017 Huang RL,Su PH, Liao YP, Wu TI, Hsu YT,Lin WY, Wang HC, Weng YC, Ou YC, Huang TH, Lai HC. Integrated epigenomics analysis reveals a DNA methylation panel for endometrial cancer detection using cervical scrapings . Clinical Cancer Research .2017 ;(23):263-272

38. 2016 Li-Chun Liu,Hung-Cheng Lai,Yu-Ching Chou,Rui-Lan Huang,Mu-Hsien Yu,Lin CP, Tsai WC, Chiang KJ, Wang YC, Chao TK. Paired boxed gene 1 expression: A single potential biomarker for differentiating endometrial lesions associated with favorable outcomes in patients with endometrial carcinoma . The Journal of Obstetrics and Gynaecology Research .2016 ;(42):1159-1167

39. 2016 Lin CK,Bai MY,Hu TM,Wang YC,Chao TK,Weng SJ, Ma KH, Lai HC*. Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in ovarian cancer . Oncotarget .2016

40. 2015 Chou JL,Huang RL,Jacqueline Shay,Chen LY,Lin SJ,Pearlly S. Yan, Chao WT, Lai YH, Lai YL, Chao TK, Lee CI, Tai CK, Wu SF, Kenneth P. Nephew, Tim H.-M. Hypermethylation of the TGF-beta target, ABCA1 is associated with poor prognosis in ovarian cancer patients. . Clinical Epigenetics .2015 ;(17):0-0

41. 2015 Wang PH,Sun HD,Lin H,Wang KL,Liou WS,Hung YC, Chiang YC, Lu CH, Lai HC, Chang TC; Taiwanese Gynecologic Oncology Group. Outcome of patients with recurrent adult-type granulosa cell tumors – A Taiwanese Gynecologic Oncology Group study . Taiwan J Obstet Gynecol .2015 ;(54):253-259

42. 2015 Par Bahadur Pun,Liao YP,Su PH,Wang HC,Chen YC,Hsu YW; Huang RL; Chang CC, Lai HC. Triage of high-risk human papillomavirus-positive women by methylated POU4F3 . Clinical Epigenetics .2015 ;(7):85-92

43. 2015 Chen TC,Huang HJ,Wang TY,Yang LY,Chen CH,Cheng YM, Liou WH, Hsu ST, Wen KC, Ou YC, Hung YC, Lai HC, Ho CM, Chang TC. Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study. . Gynecol Oncol .2015 ;(137):468-473

44. 2015 Chang CC,Ou YC,Wang KL,Chang TC,Cheng YM,Chen CH, Chu TY, Hsu ST, Liou WS, Chang YY, Wu HH, Chen TH, Lai HC. Triage of Atypical Glandular Cell by SOX1 and POU4F3 Methylation: A Taiwanese Gynecologic Oncology Group (TGOG) Study . PLoS One .2015 ;(10)

45. 2015 Chang CC,Huang RL,Liao YP,Su PH,Hsu YW,Wang HC, Tien CY, Yu MH, Lin YW, Lai HC. Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm. . BMC Cancer .2015 ;(15):418-426

46. 2015 Jadhav RR,Ye Z,Huang RL,Liu J,Hsu PY,Huang YW, Rangel LB, Lai HC, Roa JC, Kirma NB, Huang TH, Jin VX. Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer. . Clin Epigenetics .2015 ;(7)

47. 2014 Huang RY,Chen GB,Matsumura N,Lai HC,Mori S,Li J, Wong MK, Konishi I, Thiery JP, Goh LK. Histotype-specific copy-number alterations in ovarian cancer. . BMC Med Genomics. .2014 ;(5)

48. 2014 Benjamin AT Rodr,David Frankhouser,Mark Murphy,Michael Trimarchi,Hok-Hei Tam,John Curfman, Rita Huang, Michael WY Chan, Lai HC, Deval Parikh, Bryan Ball, Sebastian Schwind, .... Methods for high-throughput MethylCap-Seq data analysis. . BMC Genomics .2014 ;(suppl6):0-0

49. 2014 Huang YK,Peng BY,Wu CY,Su CT,Wang HC,Lai HC. DNA Methylation of SOX1 and PAX1 as biomarker for oral cancer detection . Clin Oral Inest. .2014 ;(18):801-808

50. 2014 Yo YT,Lin YW,Wang YC,Balch C,Huang RL,Chan M.W.Y., Sytwu HK, Chen CK, Chang CC, Nephew KP, Huang T, Yu MH, Lai HC*. Growth inhibition of ovarian tumor-initiating cells by niclosamide. . Mol Cancer Ther .2014 ;(11):1703-1712

51. 2014 Yu PN,Yan MD,Lai HC,Huang RL,Chou YC,Lin WC, Yeh LT, Lin YW. Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. . Int J Cancer. .2014 ;(134):543-551

52. 2014 Liu KC,Yo YT,Huang RL,Wang YC,Liao YP,Huang TS, Chao TK, Lin CK, Weng SJ, Ma KH, Chang CC, Yu MH, Lai HC*.. Ovarian cancer stem-like cells show induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor. . Oncotarget. .2014 ;(4):2366-2382

53. 2014 Liao YP,Huang RL,Su PH,Yo YT,Michael W.Y. Chan,Chang CC, Yu MH, Wang PH, Yen MS, Kenneth P. Nephew, Lai HC*.. Hypomethylation Signature of Tumor-initiating Cells Predicts Poor Prognosis of Ovarian Cancer Patients. . Hum Mol Genet. .2014 ;(23):1894-1906

54. 2014 ChangCC,Huang RL,Wang HC,Liao YP,Yu MH,Lai HC*. High Methylation Rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 Genes in Cervical Adenocarcinomas . Int J Gynecol Cancer .2014 ;(24):201-209

55. 2014 Chen YC,Huang RL,Huang YK,Laio YP,Su PH,Wang HC, Chang CC, Lin YW, Yu MH, Chu TY , Lai HC*.. Methylomics analysis identifies epigenetically silenced genes and implies an activation of b-catenin signaling in cervical cancer . Int J Cancer. .2014 ;(135):117-127

56. 2014 Lai HC,WangYC,Yu MH,Huang RL,Yuan CC,Chen KJ , Wu CC ,Chiang KJ ,Chao TK. DNA methylation as a biomarker for the detection of hidden carcinoma in endometrial atypical hyperplasia. . Gynecol Oncology .2014

57. 2013 Hsu YT,Gu F,Huang YW,Liu J,Ruan J,Huang RL, Wang CM, Chen CL, Lai HC, Mutch DG, Goodfellow P, Thompson IM, Kirma NB, Huang TH.. Promoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancer. . Clin Cancer Res. .2013 ;(19):6272-6285

58. 2013 Rao X,Evans J,Chae H,Pilrose J,Kim S,Yan P, Huang RL, Lai HC, Lin H, Liu Y, Miller D, Rhee JK, Huang YW, Gu F, Gray JW, Huang TM, Nephew. CpG island shore methylation regulates caveolin-1 expression in breast cancer. . Oncogene .2013 ;(32):4519-4528

59. 2013 Wang YC,Chao TK,Chang CC,Yo YT,Yu MH,Lai HC*. Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells. . PLoS One. .2013 ;(8):e74538

60. 2013 Huang HH,Liu LC,Tan SJ,Lai HC*. Robot-assisted excision of a symptomatic deep infiltrating cervical endometrioma. . Taiwan J Obstet Gynecol. .2013 ;(52):437-439

61. 2013 Chao TK,Yo YT,Liao YP,Wang YC,Su PH,Huang TS, Lai HC*. LIM-homeobox transcription factor 1, alpha (LMX1A) inhibits tumourigenesis, epithelial–mesenchymal transition and stem-like properties of epithelial ovarian cancer. . Gynecol Oncol .2013 ;(128):475-482

62. 2013 Huang RL,Gu Fei,Nameer B. Kirma,Jianhua Ruan,Chen CL,Wang HC, Liao YP, Chang CC, Yu MH, Ian M. Thompson, Huang HC, Tim Hui-Ming Huang, Lai HC*, Kenneth P. Comprehensive Methylome Analysis of Ovarian Tumor Reveals Hedgehog Signaling Pathway Regulators as Prognostic DNA Methylation Biomarkers. . Epigenetics. .2013 ;(8):624-634

63. 2013 Chao TK,Ke FY,Liao YP,Wang HC,Yu CP,Lai HC*. Triage of Cervical Cytological Diagnoses of Atypical Squamous Cells by DNA Methylation of Paired Boxed Gene 1 (PAX1) . Diagnostic Cytopathology. .2013 ;(41):41-46

64. 2013 Su PH,Lin YW,Huang RL,Liao YP,Lee HY,Wang HC, Chao TK, Chen CK, Chan Michael W.Y. , Chu TY, Yu MH, Lai HC*. Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. . Oncogene. .2013 ;(32):15-26

65. 2013 Chau WK,Ip CK,Mak AS,Lai HC,Wong AS. c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/b-catenin–ATP-binding cassette G2 signaling. . Oncogene .2013 ;(32):2767-2781

66. 2012 Yi-Te Yo,Ya-Wen Lin,Yu-Chi Wang,Curt Balch,Rui-Lan Huang,Chan M.W.Y., Sytwu HK, Chen CK, Chang CC, Nephew KP, Huang T, Yu MH, Lai HC. Growth Inhibition of Ovarian Tumor Niclosamide . Molecular Cancer Therapeutics .2012 ;(11):1703-1712

67. 2012 Tan SJ,Lin CK,Fu PT,Liu YL,Sun CC,Chang CC, Yu MH, Lai HC*.. Robotic surgery in complicated gynecologic diseases: experience of Tri-Service General Hospital in Taiwan . Taiwan J Obstet Gynecol. .2012 ;(51):18-25

68. 2012 Sun HD,Lin H,Jao MS,Wang KL,Liou WS,Hung YC, Chiang YC, Lu CH, Lai HC, Yu MH*.. A long-term follow-up study of 176 cases with adult-type ovarian granulose. . Gynecol Oncol. .2012 ;(124):244-249

69. 2012 Wang KL,Chang TC,Jung SM,Chen CH,Cheng YM,Wu HH, Liou WS, Hsu ST, Ou YC, Yeh LS, Lai HC, Huang CY, Chen TC, Chang CJ, Lai CH*. Primary treatment and prognostic factors of small cell neuroendocrine carcinoma of the uterine cervix: A Taiwanese Gynecologic Oncology Group study. . Eur J Cancer. .2012 ;(48):1484-1494

70. 2012 Wang YC,Yo YT,Lee HY,Liao YP,Chao TK,Su PH, Lai HC*. LDH1-bright Epithelial Ovarian Cancer Cells are Associated with CD44, Drug Resistance, and Poor Clinical Outcome. . American Journal of Pathology .2012 ;(180):1159-1169

71. 2012 Huang RL,Chang CC,Su PH,Chen YC,Liao YP,Wang HC, Yo YT, Chao TK, Huang HC, Lin CY, Chu TY, Lai HC*.. Methylomic Analysis Identifies Frequent DNA Methylation of Zinc Finger Protein 582 (ZNF582) in Cervical Neoplasms . PLoS One .2012 ;(7)

72. 2011 Lin CJ,Lai HC,Wang KH,Hsiung CA,Liu HW,Ding DC, Hsieh CY, Chu TY.. Testing for methylated PCDH10 or WT1 is superior to the HPV test in detecting severe neoplasms (CIN3 or greater) in the triage of ASC-US smear results. . Am J Obstet Gynecol .2011 ;(204):21.e1-e7

73. 2011 Yeh KT,Chen TH,Yang HW,Chou JL,Chen LY,, Chen YH, Lin RI, Su HY, Chen GC, Deatherage DE, Huang YW, Yan PS, Lin HJ, Nephew KP, Huang TH, Lai. Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer. . Epigenetics. .2011 ;(6):727-739

74. 2011 Liu LC,Huang RL,Lin YC,Lai HC,Su HY,Chang FW, Yu MH*.. Squamous cell carcinoma arising from an ovarian teratoma related to human papillomavirus infection: using a PCR-based reverse-blot assay. . Taiwan J Obstet Gynecol. .2011 ;(50):543-545

75. 2010 Su HY,Lai HC,Lin YW,Liu CY,Chou YC,Lin SP, Lin WC, Yu MH*. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway . Int. J. Cancer .2010 ;(127):555-567

76. 2010 JL Chou,HY Su,LY Chen,YP Liao,Corinna Hartman-Frey,...Kenneth Nephew, Tim Huang, Lai HC *, Michael Chan*. Promoter hypermethylation of FBXO32, a novel TGF-b/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer . Laboratory Investigation. .2010 ;(90):414-425

77. 2010 Ho CM*,Lai HC,Huang SH,Chien TY,Lin MC,Chang SF, Cheng WF. Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma. . Eur J Clin Invest. .2010 ;(40):310-318

78. 2010 Huang TH,Lai HC,Liu HW,Lin CJ,Wang KH,Ding DC, Chu TY*.. Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer. . Int J Gynecol Cancer. .2010 ;(20):513-519

79. 2010 Tan SJ,Juan YH,Fu PT,Yu,MH,Lai HC*. Chemotherapy with low dose bevacizumab and carboplatin in the treatment of a patient with recurrent cervical cancer . Eur J Gynaecol Oncol. .2010 ;(31):350353

80. 2010 Lai HC*,Lin YW,Huang RL,Chung MT,Wang HC,Liao YP, Su PH, Yu MH,. Quantitative DNA methylation analysis detects cervical intraepithelial neoplasm 3 and worse . Cancer .2010 ;(116):4266-4274

81. 2010 Chou JL,Chen LY,Lai HC,Chan MW. TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy. . Expert Opinion on Therapeutic Targets .2010 ;(14):1213-1223

82. 2009 Ho CM,Lin MC,Huang SH,Huang CJ,Lai HC,Chien TY, Chang SF. PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas . Gynecol Oncol. .2009 ;(112):307-313

83. 2009 Chung MT,Lai HC,Sytwu HK,Yan MD,Shih YL,Chang CC, Yu MH, Liu HS, Chu DW, Lin YW. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. . Gynecol Oncol .2009 ;(112):645-653

84. 2009 Chung MT,Sytwu HK,Yan MD,Shih YL,Chang CC,Yu MH, Chu TY, Lai HC*, Lin YW*. Promoter Methylation of SFRPs Gene Family in Cervical Cancer. . Gynecol Oncol .2009 ;(112):301-306

85. 2009 Su HY,Lai HC*,Lin YW,Chou YC,Liu CY,Yu MH*. An Epigenetic Marker Panel for Screening and Prognostic Prediction of Ovarian Cancer. . Int. J. Cancer .2009 ;(124):387-393

86. 2009 Chou YY,Chiu SK,Lai HC,Chang FY. Tubo-ovarian abscess with Morganella morganii bacteremia. . J Microbiol Immunol Infect. .2009 ;(42):357-359

87. 2009 Liu CY,Chao TK,Su PH,Lee HY,Shih YL,Su HY, Chu TY, Yu MH, Lin YW *, Lai HC *. Characterization of LMX-1A as a metastasis suppressor in cervical cancer. . Journal of Pathology .2009 ;(219):222-231

88. 2009 Lin YW,Chung MT,Lai HC,De Yan M,Shih YL,Chang CC,Yu MH.. Methylation analysis of SFRP genes family in cervical adenocarcinoma. . J Cancer Res Clin Oncol. .2009 ;(135):1665-1674

89. 2009 Ding DC,Chiang MH,Lai HC,Hsiung CA,Hsieh CY,Chu TY. Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia. . Eur J Obstet Gynecol Reprod Biol. .2009 ;(147):215-220

研究計畫

計畫名稱
113 利用卵巢癌腫瘤類器官(OV-PDOs)作為精準醫學及免疫治療之研究(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 利用卵巢癌腫瘤類器官(OV-PDOs)作為精準醫學及免疫治療之研究(1/3)
補助單位
國家科學及技術委員會

計畫名稱
112 113年度婦幼醫學學門規劃研究推動計畫
補助單位
國家科學及技術委員會

計畫名稱
111 利用輸卵管上皮類器官培養技術開發卵巢癌早期偵測之表基因生物標記(3/3)
補助單位
國家科學及技術委員會

計畫名稱
110 利用輸卵管上皮類器官培養技術開發卵巢癌早期偵測之表基因生物標記(2/3)
補助單位
科技部

計畫名稱
110 探討BHLHE22在子宮內膜癌生成之角色
補助單位
科技部

計畫名稱
109 利用輸卵管上皮類器官培養技術開發卵巢癌早期偵測之表基因生物標記(1/3)
補助單位
科技部

計畫名稱
108 子宫内膜容受性檢測研究計畫
補助單位
酷氏基因生物科技股份有限公司

計畫名稱
108 DNA與RNA甲基化與去甲基化在卵巢癌之研究
補助單位
科技部

計畫名稱
107 表基因工程作為婦科癌症治療策略之研究(3/3)
補助單位
科技部

計畫名稱
107 子宮內膜癌分子篩檢試劑套組開發案(III)
補助單位
科技部

計畫名稱
106 表基因工程作為婦科癌症治療策略之研究(2/3)
補助單位
科技部

計畫名稱
106 子宮內膜癌分子篩檢試劑套組開發案
補助單位
科技部

計畫名稱
106 子宮內膜癌分子篩檢試劑套組開發案(Ⅱ)
補助單位
科技部

計畫名稱
105 表基因工程作為婦科癌症治療策略之研究(1/3)
補助單位
科技部

計畫名稱
105 表基因工程作為婦科癌症治療策略之研究(1/3)
補助單位

計畫名稱
105 婦產科申請補助延攬科技人才許雅婷女士參與「表基因工程作為婦科癌症治療策略之研究」研究計畫案
補助單位
科技部

計畫名稱
105 卵巢癌朝細胞的表基因分析-資深研究助理獎助金王惠貞
補助單位
財團法人國家衛生研究院

計畫名稱
105 卵巢癌幹細胞的表基因分析
補助單位
財團法人國家衛生研究院

計畫名稱
104 第一型子宫内膜癌與良性子宮腫瘤的病人內膜表基因體的差異研究-Part I
補助單位
行政院衛生署雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
104 DNA甲基化生物標記作為子宮內膜癌篩檢之研發
補助單位
衛生福利部

計畫名稱
104 卵巢癌幹細胞的表基因分析
補助單位
財團法人國家衛生研究院

計畫名稱
104 卵巢癌幹細胞的表基因分析
補助單位
財團法人國家衛生研究院

計畫名稱
104 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究(3/3)
補助單位
科技部

計畫名稱
104 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究(3/3)
補助單位
科技部

計畫名稱
103 「台加(MOST-CIHR-IG)表觀基因體學邊研討會」暨CANADIAN GE3LS AND HEALTH SERVICES AND POLICY RESEARCH CONFERENCE
補助單位
科技部

計畫名稱
103 卵巢癌幹細胞之代謝研究-II
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
103 104年度國家衛生研究院院外整合性醫藥衛生科技研究計畫優秀資深研究助理獎助-王惠貞
補助單位
財團法人國家衛生研究院

計畫名稱
103 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究
補助單位
科技部

計畫名稱
103 卵巢癌幹細胞的表基因分析
補助單位
國家衛生研究院

計畫名稱
103 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究(2/3)
補助單位
科技部

計畫名稱
103 TMU103-AE1-B06
補助單位
臺北醫學大學新聘教師計畫

計畫名稱
103 (103)新聘教師研究補助-賴鴻政教師
補助單位
臺北醫學大學

計畫名稱
102 卵巢癌幹細胞之代謝研究-I
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
102 利用新一代定序技術來開發新穎之卵巢癌甲基化生物標記
補助單位
衛生福利部

計畫名稱
102 利用新一代定序技術來開發新穎之卵巢癌甲基化生物標記
補助單位
衛生福利部

計畫名稱
102 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究(1/3)
補助單位
行政院國家科學委員會

計畫名稱
102 子宮頸癌中基化甲基化胞嘧啶與TET基因之研究(2/3)
補助單位
科技部

計畫名稱
102 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究
補助單位
科技部

計畫名稱
102 子宮頸癌中羥基化甲基化胞嘧啶與TET基因之研究
補助單位
科技部