張哲菖(Chang, Che-Chang ) 教授

Email
ccchang168@tmu.edu.tw
現   職
轉譯醫學博士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國防醫學大學生命科學研究所 博士
2000/08~2005/05
輔仁大學生物研究所 碩士
1995/08~1997/06
輔仁大學生物系 學士
1991/09~1995/06

本校學術經歷

任職單位與職稱[起迄時間]
轉譯醫學博士學位學程教授
2024/08/01~
轉譯醫學博士學位學程副教授
2018/08/01~2024/07/31
轉譯醫學博士學位學程助理教授
2012/08/01~2018/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際轉譯科學碩士學位學程副教授
2024/05/01 ~
(舊)國際轉譯科學博士學位學程籌備處副教授
2020/05/01 ~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程副教授
2020/05/01 ~
(舊)生技醫療產業研發博士學位學程助理教授
2018/01/01 ~ 2020/04/30
醫學資訊研究所助理教授
2017/03/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院博士後研究
2005/07/01~2012/07/31
長庚大學研究助理
1999/10/01~2000/07/31

專長與研究領域

學門領域
醫學之生化及分子生物
學術專長
Yeast two-hybrid
Ch-IP assay
Protein purification
Immunostaining

論文著作

清冊下載


1. 2024 Giang LH,Wu KS,Lee WC,Chu SS,Do AD,Huang MH, Lin YL, Hsieh CL, Sung SY, Yen Y, *Wong TT, and *Chang CC. RRM2 inhibition alters cell cycle through ATM/Rb/E2F1 pathway in atypical teratoid rhabdoid tumor . Neoplasia .2024 ;(58):101075

2. 2023 Yang TT,Chiang MF,Chang CC,Yang SY,Huang SW,Liao NS, Shih HM, Hsu W, Lin KI. SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis . Communications Biology .2023 ;(6):629

3. 2023 Hien Giang L,Wu KS ,Lee WC ,Chu SS, Do AD,Changou CA, Tran HM, Hsieh TH, Chen HH, Hsieh CL, Sung SY, Yu AL, Yen Y, Wong TT, Chang CC. Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor . Journal of Experimental & Clinical Cancer Research .2023

4. 2022 Chi HY,Hong W,Lai H,Hsu SH,Chang CC. Silicon Ribbon-Based Dual-Beam Optical Phased Array with Low Crosstalk and Large FoV . Applied Sciences .2022 ;(12):505

5. 2022 Lin SJ,Huang JY,Le PT,Lee CT,Chang CC,Yang YY, Su Emily CY, Lo CF, Wang HC. Expression of the AHPND Toxins PirAvp and PirBvp Is Regulated by Components of the Vibrio parahaemolyticus Quorum Sensing (QS) System . International Journal of Molecular Sciences .2022 ;(23)

6. 2022 Tsai YT,Li CY,Huang YH,Chang TS,Lin CY,Chuang CH, Wang CY, Anuraga G, Chang TH, Shih TC, Lin ZY, Chen YL, Chung I, Lee KH, Chang CC, Sung SY, Yang KH, Tsui WL, Yap CV, Wu MH. Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts . Oncogene .2022

7. 2022 Mutalik C,Okoro G,Chou Hl,Lin IH,Yougbaré S,Chang CC, Kuo TR. Phase-Dependent 1T/2H-MoS2Nanosheets for Effective Photothermal Killing of Bacteria . ACS Sustainable Chemistry and Engineering .2022 ;(10):8949-8957

8. 2022 Huang YS,Wu CC,Chang CC,Huang SF,Kuo HY,Shih HM. Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth . Cell Mol Life Sci .2022 ;(79)

9. 2022 Wu KS,Sung SY,Huang MH,Lin YL,Chang CC,Fang CL, Wong TT, Chen HH, Tsai ML. Clinical and Molecular Features in Medulloblastomas Subtypes in Children in a Cohort in Taiwan . Cancers .2022 ;(14):5419-5419

10. 2021 Chu CY,Lee YC,Hsieh CH,Yeh CT,Chao TY,Chen PH, Lin IH, Hsieh TH, Shih JW, Cheng CH, Chang CC, Lin PS, Huang YL, Chen TM, Yen Y, Ann DK, Kung HJ. Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy . Theranostics .2021

11. 2021 Kuo, WL,Tseng, LL,Chang, CC,Chen, CJ,Cheng, ML,Cheng, HH, Wu, MJ, Chen, YL, Chang, RT, Tang, HY, Hsu, YC, Lin, WJ, Kao, CY, Hsieh, WP, Kung, HJ & Wang, WC. Prognostic significance of o-glcnac and pkm2 in hormone receptor-positive and her2-nonenriched breast cancer . Diagnostics .2021 ;(11):1460

12. 2021 Yougbaré, S,Mutalik, C,Okoro, G,Lin, IH,Krisnawati, DI,Jazidie, A, Nuh, M, Chang, CC & Kuo, TR. Emerging trends in nanomaterials for antibacterial applications . International Journal of Nanomedicine .2021 ;(16):5831-5867

13. 2021 Tan SH ,Yougbaré S,Tao HY,Chang CC,Kuo TR. Plasmonic gold nanoisland film for bacterial theranostics . Nanomaterials .2021 ;(11)

14. 2021 Liang KH,Chang CC,Wu KS,Yu Alice L,Sung SY,Lee YY, Liang ML, Chen HH, Fen JJ, Chao ME, Liao YT, Wong TT. Notch signaling and natural killer cell infiltration in tumor tissues underlie medulloblastoma prognosis . Scientific Reports .2021 ;(11)

15. 2021 Lee YH,Tsai YS,Chang CC,Ho CC,Shih HM,Chen HM, Lai HL, Lee CW, Lee YC, Liao YC, Yang UC, Cheng TH, Chern Y, Soong BW. A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis . Movement Disorders .2021

16. 2021 Tsai KL,Chang CC,Chang YS,Lu YY,Tsai IJ,Chen JH, Lin SH, Tai CC, Lin YF, Chang HW, Lin CY, Su ECY. Isotypes of Autoantibodies Against Novel Differential 4-Hydroxy-2-nonenal-modified Peptide Adducts in Serum Is Associated with Rheumatoid Arthritis in Taiwanese Women . BMC Medical Informatics and Decision Making .2021 ;(21):49

17. 2020 Cheng TM,Li R,Kao YCJ,Hsu CH,Chu HL,Lu KY, Changou CA, Chang CC, Chang LH, Tsai ML, Mig FL. Synthesis and characterization of Gd-DTPA/fucoidan/peptide complex nanoparticle and in vitro magnetic resonance imaging of inflamed endothelial cells . Materials Science & Engineering C .2020 ;(114):111064

18. 2020 Lu YT,Bagus BY,Hsu SH,Chang CC. Tandem Mach Zehnder Directional Coupler Design and Simulation on Silicon Platform for Optical Coherence Tomography Applications . Sensors .2020 ;(20):1054-1065

19. 2020 Zhang RA,Lin TS,Liu WT,Hsu SH,Chang CC. Grating Lobe-Free Beam Steering through Optical Phase Array Using Phase-Compensated Two Index-Mismatched SiliconWires-Based Emitters . Applied sciences .2020 ;(10):1225-1231

20. 2020 Wu KS,Ho D MT,Jou ST,Yu AL,Tran HM,Liang ML, Chen HH, Lee YY, Chen YW, Lin SC, Chang FC, Tsai ML, Liu YL, Lee, HL, Hsieh K LC, Huang WC, Sung SY, Chang CC, Changou CA, Liang KH, Hsieh TH, Liu YR, Chao ME, Chen W, Chu SS, Cho EC, Wong TT.. Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan . Cancers .2020

21. 2020 Tran HM,Wu KS,Sung SY,Changou C A,Hsieh TH,Liu YR, Liu YL, Tsai ML, Lee HL, Hsieh K LC, Huang WC, Liang ML, Chen HH, Lee YY, Lin SC, Ho D MK, Chang FC, Chao ME, Chen W, Chu SS, Yu A L, Yen Y, Chang CC*, and Wong TT*. Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors . Cancers .2020 ;(12):752

22. 2019 Hung PF,Hong TM,Chang CC,Hung CL,Hsu YL,Chang YL, Wu CT, Chang GC, Chan NL, Yu SL, Yang PC, Pan SH. Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis . J Exp Clin Cancer Res. .2019 ;(38):5-23

23. 2019 Cheng, C.F.,Ku, H.C.,Cheng, J.J.,Chao, S.W.,Li, H.F.,Lai, P.F., Chang, C.C., Don, M.J., Chen, H.H. and Lin, H.. Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3 . Communications Biology .2019 ;(2):389-406

24. 2018 Chiang WF,Cheng TM,Chang CC,Pan SH,Changou CA,Chang TH, Lee KH, Wu SY, Shieh DB, Chen YL, Tu CC, Tsui WL and Wu MH. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation . Oncogene .2018 ;(37):116-127

25. 2018 Cheng CW,Chang CC,Patria YN,Chang RT,Liu YR,Li FA, Shih HM, Lin CY. Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer . Cancer Medicine .2018 ;(7):64-74

26. 2018 Cheng TM,Chu HL,Lee YC,Wang DY,Chang CC,Chung KL, Yen HC, Hsiao CW, Pan XY, Kuo TR and Chen CC. Quantitative Analysis of Glucose Metabolic Cleavage in Glucose Transporters Overexpressed Cancer Cells by Target-Specific Fluorescent Gold Nanoclusters . Analytical Chemistry .2018 ;(90):3974-3980

27. 2018 Lin CY,Yang ST,Shen SC,Hsieh YC,Hsu FT,Chen CY, Chiang YH, Chuang JY, Chen KY, Hsu TI, Leong WC, Su YK, Lo WL, Yeh YS, Patria YN, Shih HM, Chang CC, Chou SY. Serum amyloid A1 (SAA1) in combination with integrin αVβ3 increases glioblastoma cells mobility and progression. . Molecular Oncology .2018 ;(12):756-771

28. 2018 Hu LY,Chang CC,Huang YS,Chou WC,Lin YM,Ho CC, Chen WT, Shih HM, Hsiung CN, Wu PE, Shen CY. SUMOylation of XRCC1 activated by poly(ADP-ribosyl)ation regulates DNA repair . Human Molecular Genetics .2018 ;(27):2306-2317

29. 2018 Cheng CW,Chang CC,Chen HW,Lin CY,Chen JS. Serum ApoA4 levels predicted the progression of renal impairment in T2DM . Eur J Clin Invest. .2018 ;(48):e12937-12947

30. 2018 Chang CC,Huang YS,Lin YM,Lin CJ,Jeng JC,Liu SM, Ho TL, Chang RT, Changou CA, Ho CC and Shih HM. The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis . Scientific Reports .2018 ;(8):9786-9797

31. 2017 Hsu SH,Chuang KW,Chen CS,Lin CY,Chang CC. Two Interrogated FBG Spectral Linewidth for Strain Sensing through Correlation . Sensors .2017 ;(17):pii:E2837-2843

32. 2017 Chang YS,Pan CH,Chang CC,Tsai KL,Chou HW,Chen JH, Lin SH, Lu YY, Tai CC, Lin YF and Lin CY. Low Levels of IgG Recognizing the α-1-Antitrypsin Peptide and Its Association with Taiwanese Women with Primary Sjögren’s Syndrome . Int. J. Mol. Sci. .2017 ;(18):pii: E2750-2762

33. 2017 Wu MH,Chen YL,Lee KH,Chang CCC,Cheng TM,Wu SY, Tu CC, and Tsui WL. Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β-and PDGF-like signals in hepatic stellate cells . Scientific Reports .2017 ;(7):11006-11021

34. 2016 Huang YS,Chang CC,Lee SS,Jou YS,Shih HM. Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression . Oncotarget .2016 ;(7):43256-43266

35. 2016 Hsu SH,Lin CY,Tua CT,Chang CC. MicroRNA biosensing through spectral interferometry-based surface plasmon resonance using telecommunication wavelength . Electronics Letters .2016 ;(52):1096-1098

36. 2014 Kung Camy CH,Naik MT,Wang SH,Shih HM,Chang CC,Lin LY, Chen CL, Ma C, Chang CF, Huang TH. Structural analysis of poly-SUMO chain recognition by RNF4-SIMs domain . Biochemical Journal .2014 ;(462):53-65

37. 2014 Kuo CY,Li X,Kong XQ,Luo C,Chang CC,Chung Y., Shih HM, Li KK., Ann DK. An arginine-rich motif of Ring Finger Protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated KAP1/TRIM28 during genotoxic stress . J Biol. Chem. .2014 ;(289):20757-20772

38. 2013 Hsieh YL,Kuo HY,Chang CC,Naik MT,Liao PH,Ho CC, Huang TC, Jeng JC, Hsu PH, Tsai MD, Huang TH, Shih HM.. Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response. . EMBO J. .2013 ;(32):791-804

39. 2013 Chen CH,Chang CC,Lee TH,Luo M,Huang P,Liao PH, Wei S, Li FA, Chen RH, Zhou XZ, Shih HM, Lu KP. SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function . Cancer Research .2013 ;(73):3951-3962

40. 2012 Huang YS,Chang CC,Huang TC,Hsieh YL,Shih HM. Daxx interacts with and modulates the activity of CREB . Cell Cycle .2012 ;(11):99-108

41. 2012 Ying HY,Su ST,Hsu PH,Chang CC,Lin IY,Tseng YH, Tsai MD, Shih HM, Lin KI. SUMOylation of Blimp1 is critical for plasma cell differentiation . EMBO Reports .2012 ;(13):631-637

42. 2011 Naik MT,Chang CC,Naik NM,Kung CC,Shih HM,Huang TH. NMR chemical shift assignments of a complex between SUMO1 and SIM peptide derived from the C-terminal of Daxx . Biomol NMR Assign .2011 ;(5):75-77

43. 2011 Chang CC,Naik MT,Huang YS,Jeng JC,Liao PH,Kuo HY,Ho CC,Hsieh YL,Lin CH,Huang NJ,Naik NM,Kung CC,Lin SY,Chen RH,Chang KS,Huang TH,Shih HM. Structural and functional role of Daxx SIM phosphorylation in SUMO paralogueselective binding and apoptosis modulation . Mol. Cell .2011 ;(42):62-74

44. 2007 Chao TT,Chang CC,Shih HM. SUMO modification modulates the transrepression activity of PLZF . Biochem. Biophys. Res. Commun. .2007 ;(358):475-82

45. 2007 Shih HM,Chang CC,Kuo HY,Lin DY. Daxx mediates SUMOdependent transcriptional control and subnuclear compartmentalization . Biochemical Society .2007 ;(35):1397-1400

46. 2006 Lin DY,Huang YS,Jeng JC,Kuo HY,Chang CC,Chao TT, Ho CC, Chen YC, Lin TP, Fang HI, Hung, CC, Suen CS, Hwang MJ, Chang KS, Maul GG, Shih HM. Role of SUMOinteracting motif in Daxx sumoylation, subnuclear localization and repression of sumoylated transcription factors . Mol. Cell .2006 ;(24):341-354

47. 2005 Chang CC,Lin DY,Fang HI,Chen RH,Shih HM. Daxx mediates the SUMOdependent transcriptional repression of Smad4 . J. Biol. Chem. .2005 ;(280):10164-10173

48. 2005 Kuo HY,Chang CC,Jeng JC,Hu HM,Lin DY,Maul GG, Kwok RP, Shih HM. SUMO modification negatively modulates the transcriptional activity of CREBBinding Protein via the recruitment of Daxx . Proc. Natl. Acad. Sci. USA .2005 ;(102):16973-16978

研究計畫

計畫名稱
113 開發用於中樞非典型畸形/橫紋肌樣瘤治療的潛在標的並探討其在臨床前試驗的應用(3/3)
補助單位
國家科學及技術委員會

計畫名稱
113 「開發用於中樞非典型畸形/橫紋肌樣瘤治療的潛在標的並探討其在臨床前試驗的應用」-越南籍LE HIEN GIANG LE HIEN GIANG君
補助單位
國家科學及技術委員會

計畫名稱
112 The discovery of a EZH2 inhibitor as a potential cancer treatment for MB and ATRT
補助單位
國家科學及技術委員會

計畫名稱
112 開發用於中樞非典型畸形/橫紋肌樣瘤治療的潛在標的並探討其在臨床前試驗的應用(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 「補助國內研究生出席國際學術會議」EACR 2024 年年會(研究生:轉譯醫學博士學位學程博士班LE HIEN GIANG君)
補助單位
國家科學及技術委員會

計畫名稱
111 利用in vitro和in vivo平台檢測小泛素化蛋白抗體的專一性及其在臨床檢體之應用
補助單位
國家科學及技術委員會

計畫名稱
111 具有高生物感測靈敏度之環降環型共振器
補助單位
臺北醫學大學

計畫名稱
111 開發用於中樞非典型畸形/橫紋肌樣瘤治療的潛在標的並探討其在臨床前試驗的應用(1/3)
補助單位
國家科學及技術委員會

計畫名稱
111 AACR 2023 年年會(研究生:轉譯醫學博士學位學程博士班LE HIEN GIANG君)
補助單位
國家科學及技術委員會

計畫名稱
109 藉由串聯微環形共振器之干涉波包Ring-down 來提升感測靈敏度
補助單位
臺北醫學大學

計畫名稱
108 探討小泛素蛋白?Sentrin-specific protease 2的調控機制及其在上皮細胞間質轉化與乳癌幹性中扮演的角色
補助單位
科技部

計畫名稱
107 以能量關聯線寬特性研製高靈敏微環型共振器之生物感測器
補助單位
臺北醫學大學

計畫名稱
106 表面電漿共振空間相關影像生醫感測器
補助單位
臺北醫學大學

計畫名稱
106 探討小泛素蛋白酉每Sentrin-specific protease 2在三陰性乳癌中調節Smad4蛋白的小泛素化之分子機制及功能(3/3)
補助單位
科技部

計畫名稱
105 Creating the SUMOylated-factor specific antibody and the application in biochemical analysis
補助單位
科技部

計畫名稱
105 使用級聯低同調干涉之表面電漿技術於微小核醣核酸相位感測
補助單位
臺北醫學大學

計畫名稱
105 探討小泛素蛋白酶Sentrin-specific protease 2在三陰性乳癌中調節Smad4蛋白的小泛素化之分子機制及功能(2/3)
補助單位
科技部

計畫名稱
105 探討小泛素蛋白?Sentrin-specific protease 2在三陰性乳癌中調節Smad4蛋白的小泛素化之分子機制及功能(2/3)
補助單位

計畫名稱
104 以大腸癌患者衍生異種移植小鼠模式進行抗癌藥物處理的基因表現之剖析
補助單位
科技部

計畫名稱
104 矽線波導雙金屬表面電漿干涉於微小核醣核酸之生醫感測
補助單位
臺灣科技大學

計畫名稱
104 探討小泛素蛋白酉每Sentrin-specific protease 2在三陰性乳癌中調節Smad4蛋白的小泛素化之分子機制及功能(1/3)
補助單位
科技部

計畫名稱
104 探討小泛素蛋白?Sentrin-specific protease 2在三陰性乳癌中調節Smad4蛋白的小泛素化之分子機制及功能(1/3)
補助單位
科技部

計畫名稱
103 探討小泛素蛋白酶SENP2 (SENTRIN-SPECIFIC PROTEASE 2)在乳癌幹細胞生成過程中扮演之角色
補助單位
科技部

計畫名稱
103 探討小泛素蛋白?Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)
補助單位
行政院國家科學委員會

計畫名稱
103 高靈敏表面電漿干涉於微小核醣核酸之生醫感測
補助單位
北醫大/台科大

計畫名稱
102 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)
補助單位
行政院國家科學委員會

計畫名稱
102 探討小泛素蛋白SENTRIN-SPECIFIC PROTEASE 2 參與轉型生長因子-BETA訊息傳遞的作用機制(1-2)
補助單位
科技部

計畫名稱
102 探討小泛素蛋白SENTRIN-SPECIFIC PROTEASE 2 參與轉型生長因子-BETA訊息傳遞的作用機制(2/2)
補助單位
科技部

計畫名稱
101 探討小泛素蛋白?Sentrin-specific protease 2參與PML降解的作用機制
補助單位
行政院國家科學委員會

計畫名稱
101 TMU101-AE1-B41
補助單位
學校