方旭彬(Fang, Shiuh-Bin) 教授

Email
sbfang@tmu.edu.tw
現   職
小兒學科 教授
研究發展處 副研發長
醫學院 副院長

學經歷

學 歷

畢業學校與學位[修業時間]
英國倫敦大學學院皇家自由醫學院兒童健康學 博士
2007/03~2011/05
台北醫學大學醫學系 學士
1986/09~1993/06

本校學術經歷

任職單位與職稱[起迄時間]
小兒學科教授
2023/08/01~
小兒學科副教授
2018/02/01~2023/07/31
小兒學科助理教授
2012/08/01~2018/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學院副院長
2024/04/01 ~
研究發展處副研發長
2024/02/01 ~
醫學系副主任
2018/08/01 ~ 2024/03/31
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程助理教授
2015/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
台北醫學大學醫學系小兒學科助理教授
台北醫學大學署立雙合醫院小兒部主治醫師
國立台北護理學院嬰幼兒保育系講師
2001/08/01~2001/02/28
台北台安醫院小兒科部主治醫師
2001/03/01~2011/06/15
中山醫學大學附設醫院兒童部主治醫師
2000/08/01~2001/02/15
馬偕紀念醫院小兒部住院醫師
1995/08/01~2000/07/31

專長與研究領域

學門領域
桿菌屬細菌研究
Bacillus Research
微生物及免疫學
Microbiology and Immunology
小兒科
Pediatrics
微生物免疫
Microbiology and Immunology
小兒醫學
Pediatric Medicine
學術專長
細菌抗藥機轉
細菌抗藥機轉
細菌致病機制
細菌致病機制
細菌抗藥性
細菌抗藥性
細菌致病機制
細菌致病機制
細菌學
細菌學
微生物基因體學
微生物基因體學
小兒胃腸學
小兒胃腸學
小兒肝膽
小兒肝膽
小兒腸胃
小兒腸胃
小兒消化
小兒消化
小兒超音波學
小兒超音波學
分子微生物學
分子微生物學
抗生素抗藥性
抗生素抗藥性
小兒營養學
小兒營養學
微生物學
微生物學
益生菌 (Probiotics)
人類腸道組織體外培養 (Human intestinal in vitro organ culture)
非傷寒沙門氏桿菌 (nontyphoidal Salmonella)
M細胞體外培養 (In vitro M cell culture)

論文著作

清冊下載


1. 2024 Shiuh-Bin Fang. Can the administration of probiotics in pregnant mothers reduce Group B streptococcus maternal colonization and mother-to-infant vertical transmission? . Pediatrics and Neonatology .2024 ;(65):109-110

2. 2024 Arul P*,Huang ST*,Nandhini C,Huang CH,Gowthaman NSK,Fang SB*. Development of morphologically tunable cobalt-zeolitic framework with copper nanowires: A bifunctional catalyst for the analysis of nitrobenzene and ortho-nitrobenzaldehyde in environmental effluents . Journal of Environmental Chemical Engineering .2024 ;(12):113090

3. 2023 Kumaragurubaran N,Arul P,Huang ST,Huang CH,Fang SB,Lin YH. Nanocatalyst coupled with a latent-ratiometric electrochemical switch for label-free zero-tolerance rapid detection of live Salmonella in whole blood samples . Sensors and Actuators .2023 ;(381):133428

4. 2023 Fang SB. Intestinal anti-tissue transglutaminase IgA deposits as an early diagnostic tool for potential celiac disease in children with type-1 diabetes . Pediatrics and Neonatology .2023 ;(64):369-370

5. 2023 Lee YJ†,Chang YC†,Lee IH,Ho KH,Fang SB,Lauderdale TL, Chen TW, Chen KC, Huang CH, Huang TW. Persistence and dynamic structures of diverse cephalosporinase genes in nontyphoidal Salmonella in cross-sectional surveillance in Taiwan . International Journal of Antimicrobial Agents .2023 ;(62)

6. 2023 Huang WC,Chen WT,Chen YC,Fang SB,Huang TW,Chang PR, Chang YC. Salmonella YqiC exerts its function through an oligomeric state . Protein Science .2023 ;(32)

7. 2023 Maeda K,Shigemura K,Fang SB,Yang YM,Chiang YT,Sung SY, Chen KC, Nakano Y, Miyara T, Fujisawa M. A Comparison of the Impact of the COVID-19 Pandemic on Urological Surgeries in Japan and Taiwan . International Journal of Urology .2023 ;(30):43-49

8. 2022 Fan HH†, Fang SB†*,Chang YC,Huang ST,Huang CH,Chang PR,Chang WC, Lauderdale TY, Lin PC, Cheng HY. Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium . Journal of Biomedical Science .2022 ;(29):102

9. 2022 Yang CW,Kao YC,Lin PC,Chien HY,Lin SC,Lee YH, Huang YL, Fang SB. Case report: Proteinase 3 antineutrophil cytoplasmic antibody–associated ulcerative colitis presenting as recurrent intestinal pseudo-obstruction in a teenage patient with in situ proteinase 3 immunohistochemical staining . Frontiers in Pediatrics .2022 ;(10):1-7

10. 2022 Miura M,Shigemura K,Osawa K,Nakanishi N,Nomoto R,Onishi R, Yoshida H, Sawamura T, Fang SB, Chiang YT, Shung SY, Chen KC, Miyara T, Fujisawa M. Genetic characteristics of azithromycin-resistant Neisseria gonorrhoeae collected in Hyogo, Japan during 2015-2019 . Journal of Medical Microbiology .2022 ;(71)

11. 2022 Chen CC,Chen SY,Fang SB,Lu SC,Bai CH,Wang YH. Diagnostic accuracy of SARS-CoV-2 antigen test in the pediatric population: a systematic review and meta-analysis . Pediatrics and Neonatology .2022

12. 2022 Onishi R,Shigemura K,Osawa K,Yang YM,Maeda K,Tanimoto H, Kado M, Fang SB, Sung SY, Miyara T, Fujisawa M. Impact on quinolone resistance of plasmid-mediated quinolone resistance gene and mutations in quinolone resistance-determining regions in extended spectrum beta lactamase-producing Klebsiella pneumoniae isolated from urinary tract infection patients . Pathogens and disease .2022 ;(80):1-8

13. 2022 Tanimoto H,Shigemura K,Osawa K,Kado M,Onishi R,Fang SB, Sung SY, Miyara T, Fujisawa M. Comparative genetic analysis of the antimicrobial susceptibilities and virulence of hypermucoviscous and non-hypermucoviscous ESBL-producing Klebsiella pneumoniae in Japan . Journal of Microbiology, Immunology and Infection .2022 ;(S1684-1182):00139-6

14. 2021 Fang SB,Lauderdale TY,Huang CH,Chang PR,Wang YH,Shigemura K, Lin YH, Chang WC, Wang KC, Huang TW, Chang YC. Genotypic diversity of ciprofloxacin nonsusceptibility and its relationship with minimum inhibitory concentrations in nontyphoidal Salmonella clinical isolates in Taiwan . Antibiotics .2021 ;(10):1383-1383

15. 2021 Mukai S,Shigemura K,Yang YM,Nomi M,Yanagiuchi A,Fang SB, Onish R, Sengoku A, Fujisawa M. Comparison between antimicrobial stewardship program and intervention by infection control team for managing antibiotic use in neurogenic bladder-related urinary tract infection patients: A retrospective chart audit . American Journal of Infection Control .2021 ;(S0196-6553):00707-0

16. 2021 Onishi R,Shigemura K,Osawa K,Yang YM,Maeda K,Fang SB, Sung SY, Onuma K, Uda A, Miyara T, Fujisawa M. The antimicrobial resistance characteristics of imipenem-non-susceptible, imipenemase-6-producing Escherichia coli . Antibiotics .2021 ;(11):32-32

17. 2020 Fang SB. Letter to the Editor: Enterococci and food safety – Are all probiotics beneficial? . Pediatrics and Neonatology .2020 ;(61):359-360

18. 2020 Wang KC,Huang CH,Chang PJ,Huang MT,Fang SB. Role of wzxE in Salmonella Typhimurium lipopolysaccharide biosynthesis and interleukin-8 secretion regulation in human intestinal epithelial cells . Microbiological Research .2020 ;(238):126502

19. 2020 Sun WS,Lee YJ,Tsai KN,Ho YH,Fang SB. Probiotic cocktail identified by microbial network analysis inhibits growth, virulence gene expression, and host cell colonization of vancomycin-resistant enterococci . Microorganisms .2020 ;(8):816

20. 2020 Fan HH,Lin IC,Chen JE,Lee WH,Fang SB. Anorexia nervosa manifesting as massive ascites, hypercholesterolemia, and sequential binge eating in an 11-year-old girl . Medicine (Baltimore) .2020 ;(99):e21793

21. 2020 Lin SC,Chiang BL,Lee YJ,Chang YT,Fang SB. Pseudomonas aeruginosa sepsis presenting as oral ecthyma gangrenosum in identical twins with Bruton tyrosine kinase gene mutation: two case reports and review of the literature . Journal of Microbiology, Immunology and Infection .2020 ;(53):1030-1034

22. 2019 Fang SB. Endoscopic balloon dilatation in pediatric patients with esophageal strictures: from the past to the future . Pediatrics and Neonatology .2019 ;(60):119-120

23. 2017 Fang SB,Huang CJ,Huang CH,Wang KC,Chang NW,Pan HY, Fang HW, Huang MT, Chen CK. speG is required for intracellular replication of Salmonella in various human cells and affects its polyamine metabolism and global transcriptomes . Frontiers in Microbiology .2017 ;(8):2245

24. 2016 Wang KC,Huang CH,Huang CJ,Fang SB. Impacts of Salmonella enterica Serovar Typhimurium and Its speG Gene on the Transcriptomes of In Vitro M Cells and Caco-2 Cells . PLoS One .2016 ;(11):e01534

25. 2016 Wang KC,Huang CH,Ding SM,Chen CK,Fang HW,Huang MT, Fang SB. Role of yqiC in the Pathogenicity of Salmonella and Innate Immune Responses of Human Intestinal Epithelium . Frontiers in Microbiology .2016 ;(7):1614

26. 2015 Fang SB,Ko HY,Huang ST,Huang CH,Li LT,Chen CC, Wang KC, Pai CP, Lee HC, Fang HW. Cinnamomum osmophloeum extracts inhibit growth of Helicobacter pylori and postinfectious interleukin-8 expression in human gastric epithelial cells . RSC Advances .2015 ;(5):22097-22105

27. 2014 Fang SB,Shih HY,Huang CH,Li LT,Chen CC,Fang HW. Live and heat-killed Lactobacillus rhamnosus GG upregulate gene expression of pro-inflammatory cytokines in 5-fluorouracil-pretreated Caco-2 cells . Supportive Care in Cancer .2014 ;(22):1647-1654

28. 2013 Fang SB,Schüller S,Phillips AD. Human Intestinal in vitro Organ Culture as a Model for Investigation of Bacteria-host Interactions . Journal of Experimental and Clinical Medicine .2013 ;(5):43-50

29. 2010 Fang HW Fang SB,Chiang Chiau JS,Yeung CY,Chan WT,Jiang CB, Cheng ML, Lee HC. Inhibitory effects of Lactobacillus casei subsp. rhamnosus on Salmonella lipopolysaccharide-induced inflammation and epithelial barrier dysfunction in a co-culture model using Caco-2/peripheral blood mononuclear cells . Journal of Medical Microbiology .2010 ;(59):573-579

30. 2009 Fang SB,Tseng WY,Lee HC,Tsai CK,Huang JT,Hou SY. Identification of Salmonella using colony-print and detection with antibody-coated gold nanoparticles . Journal of Microbiological Methods .2009 ;(77):225-228

31. 2009 Fang SB,Lee HC,Hu JJ,Hou YS,Liu HL,Fang HW. Dose-dependent effect of Lactobacillus rhamnosus on quantitative reduction of faecal rotavirus shedding in children . Journal of Tropical Pediatrics .2009 ;(55):297-301

32. 2008 Huang JT,Hou SY,Fang SB,Yu HW,Lee HC,Yang CZ. Development of a biochip using antibody-coated gold nanoparticles to detect specific bioparticles . Journal of Industrial Microbiology & Biotechnology .2008 ;(35):1377-1385

33. 2008 Huang JT,Wang GC,Tseng KM,Fang SB. A chip for catching, separating, and transporting bio-particles with dielectrophoresis . Journal of Industrial Microbiology and Biotechnology .2008 ;(35):1551-1557

34. 2008 Fang SB,Chang YT,Chuo YH,Tsai ST,Tseng CL. Hyperthermia as an early sign of intracranial hemorrhage in full-term neonates . Pediatrics and Neonatology .2008 ;(49):71-76

35. 2006 Lin PY,Fang SB,Liao WC,Lu YM,Jou HJ. Fetal ascites and second trimester maternal hepatitis C infection . Taiwanese Journal of Obstetrics and Gynecology .2006 ;(45):260-263

36. 2006 Fang HW,Yang CB,Chang CH,Huang CH,Liu HL,Fang SB. The potential role of phagocytic capacity in osteolytic process induced by polyethylene wear particles . Journal of International Medical Research .2006 ;(34):655-664

37. 2006 Lee HC,Yeung CY,Fang SB,Jiang CB,Sheu JC,Wang NL. Biliary cysts in children– Long term follow up in Taiwan . Journal of the Formosan Medical Association .2006 ;(105):118-124

38. 2005 Fang SB,Lee HC,Yeung CY,Tsai JD. Urinary tract infections in young infants with prolonged jaundice . Acta Paediatrica Taiwanica .2005 ;(46):356-360

39. 2005 Lee HC,Fang SB,Yeung CY,Tsai JD. Conjugated versus unconjugated hyperbilirubinaemia in young infants with urinary tract infections . Annals of Tropical Paediatrics .2005 ;(25):277-282

40. 2004 Yeung CY,Lee HC,Lin SP,Fang SB,Jiang CB,Huang FY. Serum cytokines in differentiating between viral and bacterial enterocolitis . Annals of Tropical Paediatrics .2004 ;(24):337-343

41. 2004 Fang SB,Sheu JN,Lue KH,Chen JY. Recurrent peritonitis with massive ascites as the initial manifestation of systemic lupus erythematosus: report of one case . Acta Paediatrica Taiwanica .2004 ;(45):111-115

42. 2003 Fang SB,Hsiao CH,Tseng CL. Spinal Burkitt’s lymphoma manifesting as nocturnal abdominal pain and constipation: a case report . Annals of Tropical Paediatrics .2003 ;(23):215-219

43. 2001 Chi H,Sun W,Chang WT,Lee HC,Fang SB. Pediatric Salmonella enterocolitis in a teaching hospital in Taitung: a four-year analysis . Acta Paediatrica Taiwanica .2001 ;(42):297-300

44. 2001 Fang SB,Lee HC,Huang FY,Chen MR. Intestinal pseudo-obstruction followed by major clinical features in Kawasaki disease: report of one case . Acta Paediatrica Taiwanica .2001 ;(42):111-114

45. 2000 Fang SB,Lee HC,Chang PY,Wang NL. Colonic perforation in two children with Campylobacter enterocolitis . European Journal of Pediatrics .2000 ;(159):714-715

46. 2000 Fang SB,Lee HC,Sheu JC,Chen BF. An unusual cause of gastrointestinal bleeding– segmental dilatation of the ileum: report of one case . Acta Paediatrica Taiwanica .2000 ;(41):93-97

47. 1999 Fang SB,Lee HC,Sheu JC,Lo ZJ,Wu BL. Prenatal sonographic detection of adrenal hemorrhage confirmed by postnatal surgery . Journal of Clinical Ultrasound .1999 ;(27):206-209


1. 2024 Lin JY,Fan FH,Batsaikhan B,Fang SB*. In vitro investigation of multi-strain probiotics and their antibiotic synergism for inhibiting multidrug-resistant nontyphoidal Salmonella . The 258th Scientific Meeting of Taiwan Pediatric Association in Taipei .2024

2. 2024 Fan FH,Lin JY,Chen JH*,Fang SB*. The effect of probiotics on decolonization of vancomycin-resistant enterococci from human gut: systemic review and meta-analysis of randomized clinical trials . The 258th Scientific Meeting of Taiwan Pediatric Association in Taipei .2024

3. 2023 Fang SB,Batsaikhan B,Lin YH,Sun WS,Chu YC,Huang ST, Wang JY, Wu YT. Antibacterial effects and mechanisms of naphthoquinone-imidazolium derivatives against ceftriaxone-resistant nontyphoidal Salmonella . The 254th Scientific Meeting of Taiwan Pediatric Association in Taipei .2023

4. 2023 Fang SB*,Batsaikhan B,Lin YH,Sun WS,Chu YC,Huang ST, Wang JY, Wu YT. Identification of compounds against ceftriaxone-resistant nontyphoidal Salmonella by Ultra-High Throughput Screening and exploration of the antibacterial effect and potential mechanism of its derivatives . The 16th Congress of Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition in Seoul, Korea .2023

5. 2022 Lin PC,Chang PR,Lin YH, Cheng HY,Fang SB. RNA sequencing and comparative analysis in global transcriptomes of nontyphoidal Salmonella from bacteremia and non-bacteremia patients after infecting human intestinal epithelium in vitro . The 250th Scientific Meeting of Taiwan Pediatric Association in Taipei .2022

6. 2021 Lin PC,Chang PR,Lin YH, Cheng HY,Chang WC,Lauderdale TY, Fang SB. yqiC is required for antibiotic-independent oxygen consumption and modulation in the electron transport chain of non-typhoidal Salmonella . The 246th Scientific Meeting of Taiwan Pediatric Association in Taipei .2021

7. 2021 Cheng HY,Chang PR,Lin YH,Chang WC,Lauderdale TY,Fang SB. yqiC is required for electron transport chain, glycolysis capacity, and antioxidation of Salmonella Typhimurium . The 6th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Vienna, Australia .2021

8. 2021 Lin YH,Chen YC,Chen WT,Chang PR,Huang TW,Chang YC, Fang SB. The oligomeric state of YqiC is critical for colonization and invasion of Salmonella Typhimurium in human intestinal epithelial cells . The 6th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Vienna, Australia .2021

9. 2021 Fang SB,Chang WC,Chou WH,Wang KC,Lin YH. Detection of ampicillin resistance in nontyphoidal Salmonella using a multigene panel identified by next-generation sequencing . The 6th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Vienna, Australia .2021

10. 2020 Cheng HY,Chang PR,Lin YH,Chang WC,Lauderdale TY,Fang SB. yqiC is required for electron transport chain, glycolysis capacity, and antioxidation of Salmonella Typhimurium . The Annual Meeting of the Taiwan Society of Pediatric Gastroenterology and Nutrition in New Taipei City .2020

11. 2020 Lin YH,Chen YC,Chen WT,Chang PR,Huang TW,Chang YC, Fang SB. The oligomeric state of YqiC is critical for colonization and invasion of Salmonella Typhimurium in human intestinal epithelial cells . The 244th Scientific Meeting of Taiwan Pediatric Association in Taichung .2020

12. 2019 Fan HH,Huang CH,Chang PJ,Sun WS,Fang SB. Regulation of yqiC on the global transcriptome of Salmonella and interaction of YqiC with Salmonella colonization in human intestinal cells . The 238th Scientific Meeting of Taiwan Pediatric Association in Taipei .2019

13. 2019 Fang SB,Chang WC,Chou WH,Wang KC. Detection of ampicillin resistance in nontyphoidal Salmonella using a multigene panel identified by next-generation sequencing . The 238th Scientific Meeting of Taiwan Pediatric Association in Taipei .2019

14. 2019 Lin CC,Chen SY,Fang SB,Chiu CH. Virological and clinical characteristics associated with viral shedding of norovirus in children's gastroenteritis . The 238th Scientific Meeting of Taiwan Pediatric Association in Taipei .2019

15. 2019 Fang SB,Huang CH,Chang PJ,Fan HH,Sun WS. Impacts of yqiC on the global transcriptome of Salmonella and interaction of YqiC with Salmonella colonization in human intestinal epithelium . FEMS 2019 The 8th Congress of European Microbiologists .2019

16. 2018 Fang SB,Lauderdale TY,Huang CH,Chang PJ,Chang WC,Wang KC, Sun WS. Genetic mutations and plasmid genes associated with ciprofloxacin resistance in nontyphoid Salmonella in Taiwan . The Annual Meeting of the Taiwan Society of Pediatric Gastroenterology and Nutrition in Tainan .2018

17. 2018 Fang SB,Lauderdale TY,Huang CH,Chang PJ,Chang WC,Wang KC, Sun WS. Genetic analysis of ciprofloxacin-resistant nontyphoid Salmonella in Taiwan . The 14th Asia Pan-Pacific Society of Pediatric Gastroenterology and Nutrition Meeting, Bangkok, Thailand .2018

18. 2018 Lin PC,Lin ZQ,Du XX,Fang SB,Kuo YT,Chen SY, Wang CY. D-lactic acidosis in an 18-year-old male of Down syndrome with the short bowel syndrome . The 236th Scientific Meeting of Taiwan Pediatric Association in Tainan .2018

19. 2017 Wang KC,Chou WH,Chang CM,Lauderdale TY,Chang WC,Fang SB. Incidences of four genetic mutations identified by next generation sequencing in the ciprofloxacin-resistant nontyphoid Salmonella clinical isolates in Taiwan—a preliminary study . The 230th Scientific Meeting of Taiwan Pediatric Association in Taipei .2017

20. 2017 Fang SB,Wang KC,Huang CJ. Upregulated genes of intracellular Salmonella Typhimurium after invasion into human intestinal epithelial cells . The 13th Congress of Asian Society for Pediatric Research, Hong Kong .2017

21. 2017 Fang SB,Chou WH,Wang KC,Chang CM,Lauderdale TY,Chang WC. Genetic epidemiology of novel genetic mutations identified by next generation sequencing in the ciprofloxacin-resistant Salmonella isolates in Taiwan . The 13th Congress of Asian Society for Pediatric Research, Hong Kong .2017

22. 2017 Fang SB,Wang KC,Huang CH,Chang PJ,Huang MT. Role of wzxE in the lipopolysaccharide biosynthesis of Salmonella Typhimurium and regulation of interleukin-8 secretion in human intestinal epithelial cells . The 232th Scientific Meeting of Taiwan Pediatric Association in Kaohsiung .2017

23. 2016 Fang SB,Wang KC,Huang CH,Lee YC,Chang TC,Kiu KT, Su YH, Huang MT, Fang HW. Innate immunity to rotavirus vaccines and a recombinant attenuated Salmonella vaccine in Caco-2 cells, in vitro M cells, and human colonic mucosa in polarized in vitro organ culture . The 1st Annual Meeting of the 7th Taiwan Society of Pediatric Gastroenterology and Nutrition in Taichung .2016

24. 2016 Fang SB,Wang KC,Huang CH,Lee YC,Chang TC,Kiu KT, Su YH, Huang MT, Fang HW. Innate immune responses to rotavirus vaccines and a recombinant attenuated Salmonella vaccine in Caco-2 cells, in vitro M cells, and ex vivo human colonic mucosa . The 5th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Montreal, Canada .2016

25. 2016 Fang SB,Wang KC,Huang CJ. Significantly regulated genes of intracellular nontyphidal Salmonella within human intestinal epithelial cells . The 228th Scientific Meeting of Taiwan Pediatric Association in Taichung .2016

26. 2016 Wang KC,Chou WH,Chang CM,Chang WC,Fang SB. Comparative analysis of antibiotic resistance patterns of nontyphoid Salmonella clinical isolates using next-generation sequencing for discovering novel genetic mutation targets . ASM Microbe 2016 in Boston, USA .2016

27. 2016 Wang KC,Chou WH,Chang CM,Chang WC,Fang SB. Identification of novel genetic mutations related to antibiotic resistance in nontyphoid Salmonella using next-generation sequencing . The 57th Annual Meeting and the 226th Scientific Meeting of Taiwan Pediatric Association and the 3rd Forum of Pediatric Nephro-Urology in Taiwan .2016

28. 2016 Lu MC,Chen JE,Fang SB,CY Wang. A left-sided Poland syndrome newborn associated with dextroposition and cardiac congenital anomalies and left intraventricular hemorrhage . The 57th Annual Meeting and the 226th Scientific Meeting of Taiwan Pediatric Association and the 3rd Forum of Pediatric Nephro-Urology in Taiwan .2016

29. 2016 Fang SB,Wang KC,Huang CH,Lee YC,Chang TC,Kiu KT, Su YH, Huang MT, Fang HW. Innate immunity to rotavirus vaccines and a recombinant attenuated Salmonella vaccine in Caco-2 cells, in vitro M cells, and human colonic mucosa in polarized in vitro organ culture . The 1st Annual Meeting of the 7th Taiwan Society of Pediatric Gastroenterology and Nutrition in Taichung, August 27-28, 2016 .2016

30. 2016 Fang SB,Wang KC,Huang CH,Lee YC,Chang TC,Kiu KT, Su YH, Huang MT, Fang HW. Innate immune responses to rotavirus vaccines and a recombinant attenuated Salmonella vaccine in Caco-2 cells, in vitro M cells, and ex vivo human colonic mucosa . The 5th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Montreal, Canada. October 5-8, 2016 .2016

31. 2016 Fang SB,Wang KC,Huang CJ. Significantly regulated genes of intracellular nontyphoidal Salmonella within human intestinal epithelial cells . The 228th Scientific Meeting of Taiwan Pediatric Association in Taichung, November 19, 2016 .2016

32. 2015 Fang SB,Wang KC,Huang CH,Huang CJ. Global regulation of gene expression in human in vitro M-cells by the speG gene of Salmonella Typhimurium . The 11th Congress of Asian Society for Pediatric Research (ASPR2015) in Osaka, Japan .2015

33. 2015 Fang SB,Wang KC,Huang CH,Ding SM,Chen CK,Fang HW, Huang MT. yqiC is required for colonization, motility, and flagellation of Salmonella Typhimurium, and interleukin-8 and human β-defensin-3 production in human intestinal epithelial cells . The 6th Congress of European Microbiologists (FEMS 2015) in Maastricht, Netherlands .2015

34. 2015 Wang KC,Fang SB,Huang CH,Huang CJ. Global regulation of gene expression in human in vitro M-cells by the speG gene of Salmonella Typhimurium . The 222th Scientific Meeting of Taiwan Pediatric Association in Taipei. .2015

35. 2015 Wang KC,Fang SB,Huang CH,Ding SM,Chen CK,Fang HW, Huang MT. yqiC is responsible for flagellation and type 3 secretion system of Salmonella Typhimurium by downregulation of type 1 fimbrial genes and biosynthesis of menaquinone. . The 222th Scientific Meeting of Taiwan Pediatric Association in Taipei. .2015

36. 2015 Fang Sb. In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes . The 2nd Japan-Taiwan-Korea Joint Meeting of Pediatric Gastroenterology, Hepatology and Nutrition in Tokyo, Japan .2015

37. 2014 Lee YH,Fang SB,Lin SC,Kao YC,Huang YL,Fang. A possible overlapping syndrome of systemic lupus erythematosus and antineutrophil cytoplasm autoantibodies-associated vasculitis presenting as recurrent intestinal pseudo-obstruction in a 13-year-old teenage girl . 台灣消化系醫學會第247次學術討論月會 .2014

38. 2014 Fang SB,Huang CH,Chang NW,Pan HY,Huang CJ,Fang HW, Huang MT, Chen CK. The impacts of speG on intracellular replication and polyamine metabolism of Salmonella Typhimurium . The 55th Annual Convention and 218th Scientific Meeting of Taiwan Pediatric Association in Taipei .2014

39. 2014 Huang CJ,Fang SB,Huang CH,Chang NW,Pan HY,Fang HW, Huang MT, Chen CK. Transcriptome analysis of genes regulated by speG in Salmonella Typhimurium before and after invasion into human intestinal epithelium . .2014

40. 2014 Fang SB,Huang CJ,Huang CH,Chang NW,Pan HY,Ding SM, Lee YC, Fang HW, Huang MT, Chen CK. The impacts of speG on transcriptome, polyamine metabolism, and bacterial virulence of Salmonella Typhimurium during in vitro infection in human intestinal epithelium . EBMO Conference on Microbiology after the genomics revolution: Genomes 2014 in Paris, France .2014

41. 2014 Wang KC,Ding SM,Huang CH,Chen CK,Fang HW,Huang MT, Fang SB. The impacts of Salmonella yqiC gene on bacterial virulence and host responses in human cell lines . The 220th Scientific Meeting of Taiwan Pediatric Association in Kaohsiung .2014

42. 2013 Pai CP,Fang SB,Ko HY,Fang HW. The anti-microbial and anti-inflammatory effects of indigenous cinnamon extract on Helicobacter pylori and Helicobacter pylori-infected human gastric epithelium . The 54th Annual Convention and 214th Scientific Meeting of Taiwan Pediatric Association in Taipei .2013

43. 2013 Huang TS,Fang SB,Shih HY,Fang HW. Regulation of 5-fluorouracil-induced inflammation in human intestinal epithelium by Lactobacillus rhamnosus GG . The 54th Annual Convention and 214th Scientific Meeting of Taiwan Pediatric Association in Taipei .2013

44. 2011 Fang SB,Lucas M,Wang J,Maskell DJ,Klein NJ,Phillips AD. Salmonella Typhimurium inhibits gene expression of human β-defensin 3 in polarised ex vivo human intestinal organ culture . The 7th World Congress of the World Society for Pediatric Infectious Disease (WSPID) in Melbourne, Australia. .2011

45. 2011 Fang SB,Chaudhuri RR,Peters SE,Wang J,Pleasance SJ,Maskell DJ, Charles IG, Parkhill J, Eckert S, Klein N, Phillips AD. Identification of virulence genes of Salmonella Typhimurium responsible for bacterial adhesion, invasion, and intracellular replication in human epithelial cells using Transposon Directed Insertion-site Sequencing (TraDIS) . The 44th Annual Meeting of European Society of Pediatric Gastroenterology, Hepatology and Nutrition in Sorrento, Italy .2011

46. 2010 Fang SB,Lucas M,Maskell JD,Phillips AD. Stimulation of IL-8 and β-defensin-2 by pathogen-associated molecular patterns of Salmonella enterica serovar Typhimurium in polarised human intestinal epithelial cells . The 43rd Annual Meeting of European Society of Pediatric Gastroenterology, Hepatology and Nutrition in Istanbul, Turkey .2010

47. 2010 Fang SB,Lucas M,Maskell JD,Phillips AD. Stimulation of IL-8 and β-defensin-2 by pathogen-associated molecular patterns of Salmonella enterica serovar Typhimurium in polarised human intestinal epithelial cells . The 6th Congress of Asian Society for Pediatric Research and 51st Annual Meeting of Taiwan Pediatric Association in Taipei, Taiwan .2010

48. 2009 Lee HC,Chiang Chiau JS,Yeung CY,Fang SB,Chan WT,Jiang CB, Fang HW, Cheng ML. Probiotic Lcr35-induced improvement in inflammatory response is associated with profile of pro-inflammatory cytokines mRNA expression in caco-2/PBMCs co-culture model . The 3rd Annual Meeting of the 4th Taiwan Society of Pediatric Gastroenterology and Nutrition in Taipei .2009

49. 2009 Chang ST,Yeung CY,Lee HC,Fang SB,Chen HW,Chen WT, Jiang CB. Mother-to-child vertical transmission of hepatitis C virus: A prospective study on risk factors and clinical courses-Preliminary report . The 3rd Annual Meeting of the 4th Taiwan Society of Pediatric Gastroenterology and Nutrition in Taipei .2009

50. 2008 Fang SB,Lucas M,Sivananthan A,Schüller S,Phillips AD. Inhibition of intracellular replication of Salmonella enterica serovar Typhimurium SL1344 and IL-8 secretion in HEp-2 cells by postinfectious administration of Lactobacillus GG and Lactobacillus plantarum 299v . The 3rd World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Iguassu Falls, Brazil .2008

51. 2008 Yeung CY,Lee HC,Chiau Chiang JS,Fang HW,Fang SB,Cheng ML. Anti-inflammatory effect of Lactobacillus Casei Variety Rhamnosus in inhibiting LPS-induced IL-8 expression by differentiated Caco-2 cells in a compartmentalized coculture model with peripheral blood mononuclear cells . The 3rd World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in Iguassu Falls, Brazil .2008

52. 2008 Fang SB,Schüller S,Phillips AD. Inhibition of IL-8 Secretion from HEp-2 Cells by Lactobacilli after Salmonella Infection and Analysis of Probiotic Ability of Reduction in Intracellular Replication of Salmonella . Acta Paediatrica Taiwanica. 49 (Suppl); Apr 2008 (The 49th Annual Convention and 194th Scientific Meeting of Taiwan Pediatric Association, Taipei .2008


1. 2010 Fang SB. 第七章 腸胃系統 . 兒童身評與診斷 .2010


1. 2023 用於檢測耐胺芐青黴素非傷寒沙門氏桿菌之方法及裝置 . 中華民國專利發明 .2023

2. 2022 Fang SB,Tsai KN,Sun WS,Ho YH,Lee YJ. 抑制具萬古黴素抗藥性腸球菌之益生菌及其組合與其用途 . 中華民國發明專利 .2022

3. 2022 Fang SB,Tsai KN,Sun WS,Ho YH,Lee YJ. Probiotic and probiotic combination for inhibition of vancomycin-resistant enterococci and use thereof . US Patent .2022

4. 2014 Fang HW,Fang SB,Ko HY,Li LT,Chen CC. 土肉桂萃取混合物及其製造方法與製備藥劑之用途 (Use of cinnamomum osmophloeum extrated mixture in manufacturing medicines) . 中華民國發明專利 (證書號數I463988, 公開編號TW201431557) .2014


1. 2011 Fang SB. Early interactions of non-typhoidal Salmonella with human epithelium . Doctoral thesis, UCL (University College London) .2011

研究計畫

計畫名稱
113 體外篩選和探討可抑制抗生素抗藥性非傷寒沙門氏桿菌之有效益生菌株以及對抗生素之加乘作用(1/2)
補助單位
國家科學及技術委員會

計畫名稱
111 萘醌咪唑小分子改造化合物對頭孢曲松抗藥性非傷寒沙門氏桿菌之抗菌作用與機轉
補助單位
臺北醫學大學

計畫名稱
110 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略
補助單位
科技部

計畫名稱
110 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略
補助單位
科技部

計畫名稱
110 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略(3/3)
補助單位
科技部

計畫名稱
109 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略
補助單位
科技部

計畫名稱
109 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略(2/3)
補助單位
科技部

計畫名稱
108 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略(1/3)
補助單位
科技部

計畫名稱
108 醫學系方旭彬副教授隨專題研究計畫申請補助延攬科技人才孫維聲先生參與「探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略」研究計畫案,業經核定以「博士後研究」資格補助(MOST 108-2811-B-038-508)
補助單位

計畫名稱
108 延攬科技人才林盈秀君參與「探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析:以雙面向方法發展對抗沙門氏菌感染之新策略」
補助單位
科技部

計畫名稱
107 探討以益生菌株最佳雞尾酒組合將人類腸道中具萬古黴素抗藥性腸球菌去定植化
補助單位
台達電子工業股份有限公司

計畫名稱
107 探討細菌抗生素抗藥性之新基因突變, 進入宿主細胞內向上調控之沙門氏菌基因, 與yqiC誘導宿主初級免疫反應之機轉用以對抗沙門氏菌感染(3/3)
補助單位
科技部

計畫名稱
106 以微生物分析流程鑑定在體外抑制具萬古黴素抗藥性腸球菌之益生菌最佳雞尾酒組合
補助單位
台達電子工業股份有限公司

計畫名稱
106 探討細菌抗生素抗藥性之新基因突變, 進入宿主細胞內向上調控之沙門氏菌基因, 與yqiC誘導宿主初級免疫反應之機轉用以對抗沙門氏菌感染(2/3)
補助單位
科技部

計畫名稱
105 探討細菌抗生素抗藥性之新基因突變, 進入宿主細胞內向上調控之沙門氏菌基因, 與yqiC誘導宿主初級免疫反應之機轉用以對抗沙門氏菌感染(1/3)
補助單位
科技部

計畫名稱
105 探討細菌抗生素抗藥性之新基因突變, 進入宿主細胞內向上調控之沙門氏菌基因, 與yqiC誘導宿主初級免疫反應之機轉用以對抗沙門氏菌感染(1/3)
補助單位

計畫名稱
104 以實驗細胞株,體外人體組織培養和臨床方法探討新發現沙門氏菌致病基因之特性
補助單位
財團法人國家衛生研究院

計畫名稱
104 博士後研究人員出國發表論文補助事
補助單位

計畫名稱
103 發展人體腸道體外組織培養及體外M細胞模式成為研究新型口服疫苗之平台
補助單位
科技部

計畫名稱
103 以實驗細胞株,體外人體組織培養和臨床方法探討新發現沙門氏菌致病基因之特性
補助單位
國家衛生研究院

計畫名稱
102 以實驗細胞株,體外人體組織培養和臨床方法探討新發現沙門氏菌致病基因之特性
補助單位
國家衛生研究院

計畫名稱
102 利用微陣列探討speG基因對鼠傷寒沙門氏菌及在體外M細胞模式中人類腸道上皮與B淋巴球細胞之全局性調控
補助單位
行政院國家科學委員會

計畫名稱
102 In vitro characterization of Salmonella virulence gene speG in human intestinal cells
補助單位
臺北科技大學

計畫名稱
101 以實驗細胞株,體外人體組織培養和臨床方法探討新發現沙門氏菌致病基因之特性
補助單位
國家衛生研究院

計畫名稱
101 Regulation of human β-defensin 3 expression in human intestinal epithelium by Salmonella enterica serovar Typhimurium
補助單位
臺北科技大學

計畫名稱
101 TMU101-AE1-B64
補助單位
雙和