林永國(Lin, Yung-Kuo)　教授

Email
yklin213@tmu.edu.tw
現   職
內科學科 教授
臺北心臟醫學研究中心 副主任

學經歷

學　歷

畢業學校與學位[修業時間]
臺北醫學大學臨床醫學研究所博士班 博士
2011/09~2014/01
陽明醫學院醫學系 學士
1985/09~1992/06

本校學術經歷

任職單位與職稱[起迄時間]
內科學科教授
2022/02/01~
內科學科副教授
2015/08/01~2022/01/31
內科學科助理教授
2012/05/01~2015/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
臺北心臟醫學研究中心副主任
2023/08/01 ~
臺北心臟醫學研究中心副主任
2020/08/01 ~ 2022/07/31

其它經歷

任職單位與職稱[起迄時間]
萬芳醫院主治醫師
2010/03~
亞東紀念醫院主治醫師
2007/09~2010/02
樂生療養院/迴龍醫院主治醫師
2006/05~2007/09
東元紀念醫院主治醫師/導管室主任
2002/11~2006/05
為恭紀念醫院主治醫師
2002/01~2002/10
台北榮民總醫院住院醫師 總醫師 主治醫師
1994/11~2001/12
蘇澳榮民醫院住院醫師(公費生)
1992/11~1994/10

專長與研究領域

學門領域
學術專長

論文著作

清冊下載

論文 Journal Paper


1. 2022 Fibroblast Growth Factor 1 Reduces Pulmonary Vein and Atrium Arrhythmogenesis via Modification of Oxidative Stress and Sodium/Calcium Homeostasis . Front Cardiovasc Med. .2022 ;(8):813589

2. 2021 Huang SY,Lu YY,Lin YK,Chen YC,CHen YA,Chung CC, Lin WS, Chen SA, Chen YJ. Ceramide modulates electrophysiological characteristics and oxidative stress of pulmonary vein cardiomyocytes . Eur J Clin Invest. .2021

3. 2021 Chung CC,Lin YK,Chen YC,Kao YH,Yeh YH,Chen YJ. Calcium Regulation on the Atrial Regional Difference of Collagen Production Activity in Atrial Fibrogenesis . Biomedicines .2021 ;(9):686

4. 2021 Calcium dysregulation increases right ventricular outflow tract arrhythmogenesis in rabbit model of chronic kidney disease . J Cell Mol Med. .2021 ;(25):11264-11277

5. 2021 Regional Diversities in Fibrogenesis Weighed as a Key Determinant for Atrial Arrhythmogenesis . Biomedicines .2021 ;(9):1900-1900

6. 2021 Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling . Int J Mol Sci. .2021 ;(23):166

7. 2021 Yen-Yu Lu,Shih-Yu Huang,Yung-Kuo Lin,Yao-Chang Chen,Yi-Ann Chen,Shih-Ann Chen, Yi-Jen Chen. Epicardial adipose tissuemodulates arrhythmogenesis in right ventricle outflow tract cardiomyocytes . Europace .2021 ;(23):970-977

8. 2020 Lkhagva B,Lin YK,Chen YC,Cheng WL,Higa S,Kao YH, Chen YJ. ZFHX3 knockdown dysregulates mitochondrial adaptations to tachypacing in atrial myocytes through enhanced oxidative stress and calcium overload . Acta Physiol (Oxf) .2020

9. 2020 Li SJ,Kao YH,Chung CC,Cheng WL,Lin YK,Chen YJ. Vascular endothelial growth factor on Runt-related transcript factor-2 in aortic valve cells . Eur J Clin Invest .2020

10. 2020 Lin YK,Cheng CC,Huang JH,Chen YA,Lu YY,Chen YC, Chen SA, Chen YJ. Various subtypes of phosphodiesterase inhibitors differentially regulate pulmonary vein and sinoatrial node electrical activities . Exp Ther Med .2020 ;(19):2773-2782

11. 2020 Liu CM, Lin FZ, Chen YC, Lin YK, Lu YY, Wu CI, Higa S, Chen SA, Chen YJ. Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia . Pflugers Arch .2020 ;(472):1783-1791

12. 2020 Lu YY,Cheng CC,Wu HJ,Lin YK,Chen YC,Chen SA, Chen YJ.. Effects of ANP on pulmonary vein electrophysiology, Ca2+ homeostasis and adrenergic arrhythmogenesis via PKA . Clin Exp Pharmacol Physiol. .2020 ;(47):247-254

13. 2020 Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling . Transl Res. .2020 ;(216):43-56

14. 2019 Chung CC,Lin YK,Chen YC,Kao YH,Lee TI,Chen YJ. Vascular endothelial growth factor enhances profibrotic activities through modulation of calcium homeostasis in human atrial fibroblasts . Lab Invest. .2019 ;(100):285-296

15. 2019 Corrigendum to "Age and thyroid hormone replacement delays the recovery from amiodarone-induced hypothyroidism" . Int J Cardiol. .2019

16. 2019 Lee TI,Chen YC,Lin YK,Chung CC,Lu YY,Kao YH, Chen YJ. Empagliflozin Attenuates Myocardial Sodium and Calcium Dysregulation and Reverses Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats . Int J Mol Sci. .2019 ;(20):pii: E1680

17. 2019 Cheng WL,Kao YH,Chao TF,Lin YK,Chen SA,Chen YJ. MicroRNA-133 suppresses ZFHX3-dependent atrial remodelling and arrhythmia . Acta Physiol (Oxf). .2019 ;(227):e13322.

18. 2019 Chan CS,Lin YK,Chen YC,Lu YY,Chen SA,Chen YJJ. Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation . Int J Mol Sci. .2019 ;(20): pii: E3224.

19. 2019 Lin YK,Chen YJ. Telocytes: Supporting cells participating in ventricular arrhythmogenesis? . J Arrhythm. .2019 ;(35):522-523

20. 2019 Huang JH,Chen YC,Lu YY,Lin YK,Chen SA,Chen YJ. Arginine vasopressin modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes . J Biomed Sci. .2019 ;(26):71.

21. 2018 Lin YK,Chen YA,Lee TI,Chen YC,Chen SA,Chen YJ. Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation . Circ J. .2018 ;(82):1237-1244

22. 2018 Yang HY,Huang JH,Chiu HW,Lin YK,Hsu CY,Chen YJ. Vitamin D and bisphosphonates therapies for osteoporosis are associated with different risks of atrial fibrillation in women: A nationwide population-based analysis . Medicine (Baltimore). .2018 ;(97):e12947

23. 2018 Chan CS,Chen YC,Chang SL,Lin YK,Kao YH,Chen SA, Chen YJ. Heart Failure Differentially Modulates the Effects of Ivabradine on the Electrical Activity of the Sinoatrial Node and Pulmonary Veins . J Card Fail. .2018 ;(24):763-772

24. 2018 Huang JH,Lin YK,Chung CC,Hsieh MH,Chiu WC,Chen YJ. Factors That Determine the Prothrombin Time in Patients With Atrial Fibrillation Receiving Rivaroxaban . Clin Appl Thromb Hemost .2018

25. 2018 Chung CC,Lin YK,Chen YC,Kao YH,Yeh YH,Chen YJ. Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrial fibroblasts with modulation of nitric oxide synthesis and calcium homeostasis . J Mol Cell Cardiol. .2018 ;(123):128-138

26. 2018 Chen YC,Chung CC,Lin YK,Chen YJ. Genetic and ethnic modulation of cardiovascular toxicity of vascular endothelial growth factor inhibitors . Ann Med. .2018 ;(50):46-56

27. 2018 Lee TW,Lee TI,Lin YK,Kao YH,Chen YJ. Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes . J Biomed Sci .2018 ;(25):42

28. 2018 Lin YK,Chen YC,Chen YA,Huang JH,Chen SA,Chen YJ. Levosimendan differentially modulates electrophysiological activities of sinoatrial nodes, pulmonary veins, and the left and right atria . . J Cardiovasc Electrophysiol .2018 ;(29):1150-1158

29. 2018 Chan CS,Lin YK,Kao YH,Chen YC,Chen SA,Chen YJ. Hydrogen sulphide increases pulmonary veins and atrial arrhythmogenesis with activation of protein kinase C . J Cell Mol Med .2018 ;(22):3503-3513

30. 2017 Lu YY,Wu WS,Lin YK,Cheng CC,Chen YC,Chen SA, Chen YJ. Angiotensin 1-7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway . Eur J Clin Invest. .2017 ;(48)

31. 2017 Chen YC,Chung CC,Lin YK,Chen YJ. Genetic and ethnic modulation of cardiovascular toxicity of vascular endothelial growth factor inhibitors . Ann Med. .2017 ;(50):46-56

32. 2017 Chen YC,Chung CC,Lin YK,Chen YJ. Genetic and ethnic modulation of cardiovascular toxicity of vascular endothelial growth factor inhibitors . Ann Med .2017 ;(27):1-11

33. 2017 Lin YK,Chen YA,Lee TI,Chen YC,Chen SA,Chen YJ. Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation . Circ J .2017

34. 2017 Huang SY,Chen YC,Kao YH,Hsieh MH,Lin YK,Chen SA, Chen YJ. Redox and Activation of Protein Kinase A Dysregulates Calcium Homeostasis in Pulmonary Vein Cardiomyocytes of Chronic Kidney Disease . J Am Heart Assoc .2017 ;(6):1-14

35. 2017 Lin YK,Cheng CC,Tsai MC,Wu PY,Chen YA,Chen YC, Chen SA, Chen YJ. Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities . Exp Ther Med .2017 ;(13):2486-2492

36. 2017 Lu YY,Cheng CC,Tsai CF,Lin YK,Lee TI,Chen YC, Chen SA, Chen YJ. Discrepant effects of heart failure on electrophysiological property in right ventricular outflow tract and left ventricular outflow tract cardiomyocytes . Clin Sci (Lond) .2017 ;(131):1317-1327

37. 2017 Chang SL,Chuang HL,Chen YC,Kao YH,Lin YK,Yeh YH, Chen SA, Chen YJ. Heart failure modulates electropharmacological characteristics of sinoatrial nodes . Exp Ther Med .2017 ;(13):771-779

38. 2017 Chung CC,Kao YH,Yao CJ,Lin YK,Chen YJ. A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress-induced mitogen-activated protein kinase signalling in rats . Acta Physiol (Oxf) .2017 ;(220):432-445

39. 2017 Huang JH,Lin YK,Hsieh MH,Chen SA,Chiu WC,Chen YJ. Modulation of Autonomic Nervous Activity in the Termination of Paroxysmal Atrial Fibrillation. . Pacing Clin Electrophysiol. .2017

40. 2016 Lu YY,Chen YC,Kao YH,Lin YK,Yen YH,Chen SA, Chen YJ. Colchicine modulates calcium homeostasis and electrical property of HL-1 cells . J Cell Mol Med .2016 ;(20):1182-1190

41. 2016 Lu YY,Lin YK,Wen ZH,Chen YC,Chen SA,Chen YJ. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes . Clinical Science .2016 ;(130):721-732

42. 2016 Huang JH,Lin YK,Hsieh MH,Chiu WC,Chen YJ. Age and thyroid hormone replacement delays the recovery from amiodarone-induced hypothyroidism. . Int J Cardiol .2016 ;(202):561-563

43. 2016 Kao YH,Hsu JC,Chen YC,Lin YK,Lkhagva B,Chen SA, Chen YJ. ZFHX3 knockdown increases arrhythmogenesis and dysregulates calcium homeostasis in HL-1 atrial myocytes . Int J Cardiol .2016 ;(210):85-92

44. 2016 Huang SY,Chen YC,Kao YH,Hsieh MH,Chen YA,Chen WP, Lin YK, Chen SA, Chen YJ. Renal failure induces atrial arrhythmogenesis from discrepant electrophysiological remodeling and calcium regulation in pulmonary veins, sinoatrial node, and atria . Int J Cardiol. .2016 ;(202):846-857

45. 2016 Lu YY,Cheng CC,Chen YC,Lin YK,Chen SA,Chen YJ. Electrolyte Disturbances Differentially Regulate Sinoatrial Node and Pulmonary Veins Electrical Activity: a Contribution to Hypokalemia or Hyponatremia-induced Atrial Fibrillation. . Heart Rhythm .2016 ;(13):781-788

46. 2016 Huang SY,Chen YA,Chen SA,Chen YJ,Lin YK. Uremic Toxins - Novel Arrhythmogenic Factor in Chronic Kidney Disease - Related Atrial Fibrillation . Acta Cardiol Sin .2016 ;(32):259-264

47. 2016 Lee P,Liu JC,Hsieh MH,Hao WR,Tseng YT,Liu SH, Lin YK, Sung LC, Huang JH, Yang HY, Ye JS, Zheng HS, Hsu MH, Syed-Abdul S, Lu R, Nguyen PA,. Cloud-based BP system integrated with CPOE improves self-management of the hypertensive patients: A randomized controlled trial. . Comput Methods Programs Biomed. .2016 ;(132):105-113

48. 2016 Chuang CY,Chang TI,Lin YK,Hsieh MH,Yeh JS. Type A intramural hematoma and hemopericardium secondary to penetrating atherosclerotic ulcer . Intern Emerg Med. .2016 ;(11):155-156

49. 2016 Tam WC,Lin YK,Chan WP,Huang JH,Hsieh MH,Chen SA, Chen YJ. Pericardial Fat Is Associated With the Risk of Ventricular Arrhythmia in Asian Patients . Circ J. .2016 ;(80):1726-1733

50. 2016 Huang SY,Chen YC,Kao YH,Hsieh MH,Lin YK,Chung CC, Lee TI, Tsai WC, Chen SA, Chen YJ. Fibroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes . Oncotarget .2016 ;(7):69231-69242

51. 2016 Lin YK,Chen YC,Chen YA,Yeh YH,Chen SA,Chen YJ. B-Type Natriuretic Peptide Modulates Pulmonary Vein Arrhythmogenesis: A Novel Potential Contributor to the Genesis of Atrial Tachyarrhythmia in Heart Failure . J Cardiovasc Electrophysiol. .2016 ;(27):1462-1471

52. 2016 Chung CC,Kao YH,Yao CJ,Lin YK,Chen YJ. A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress-induced mitogen-activated protein kinase signalling in rats . Acta Physiol (Oxf). .2016

53. 2016 Lu YY,Lin YK,Kao YH,Chung CC,Yeh YH,Chen SA, Chen YJ. Collagen regulates transforming growth factor-β receptors of HL-1 cardiomyocytes through activation of stretch and integrin signaling. . Mol Med Rep. .2016 ;(14):3429-3436

54. 2015 Chang CJ,Cheng CC,Yang TF,Chen YC,Lin YK,Chen SA, Chen YJ. Selective and non-selective non-steroidal anti-inflammatory drugs differentially regulate pulmonary vein and atrial arrhythmogenesis . Int J Cardiol. .2015 ;(184):559-67

55. 2015 Tsai WC,Lu YY,Chen YC,Chang CJ,Kao YH,Lin YK, Chen YH, Chen SA, Yang LY, Chen YJ. Ablation of androgen receptor gene triggers right ventricular outflow tract ventricular tachycardia . Int J Cardiol. .2015 ;(189):172-81

56. 2015 Lkhagva B,Lin YK,Kao YH,Chazo TF,Chung CC,Chen SA, Chen YJ. Novel Histone Deacetylase Inhibitor Modulates Cardiac Peroxisome Proliferator-Activated Receptors and Inflammatory Cytokines in Heart Failure . Pharmacology .2015 ;(96):186-91

57. 2015 Chen WT,Chen YC,Hsieh MH,Huang SY,Kao YH,Chen YA, Lin YK, Chen SA, Chen YJ. The Uremic Toxin Indoxyl Sulfate Increases Pulmonary Vein and Atrial Arrhythmogenesis. . J Cardiovasc Electrophysiol. .2015 ;(26):203-10

58. 2014 Lkhagva B,Chang SL,Chen YC,Kao YH,Lin YK,Chiu CT, Chen SA, Chen YJ. Histone Deacetylase Inhibition Reduces Pulmonary Vein Arrhythmogenesis through Calcium Regulation. . Int J Cardiol. .2014 ;(177):982-9

59. 2014 Huang SY,Lu YY,Chen YC,Chen WT,Lin YK,Chen SA, Chen YJ. Hydrogen Peroxide Modulates Electrophysiological Characteristics of Left Atrial Myocytes. . Acta Cardiol Sin. .2014 ;(30):38-45

60. 2014 Yang HY,Huang JH,Lin YK,Hsu CY,Chen SA,Chen YJ. Bipolar Disorder and Schizophrenia Present Different Risks of Atrial fibrillation: A Nationwide Population-Based Analysis. . Acta Cardiol Sin. .2014 ;(30):46-52

61. 2014 Huang JH,Lin YK,Hsieh MH,Chen SA,Chen YJ. Non-standard dose dronedarone in treating atrial fibrillation patients. . Int J Cardiol. .2014 ;(172):e214-6

62. 2014 Chen YC,Lu YY,Cheng CC,Lin YK,Chen SA,Chen YJ. Sinoatrial node electrical activity modulates pulmonary vein arrhythmogenesis . Int J Cardiol. .2014 ;(173):447-52

63. 2014 Chen YC,Huang JH,Lin YK,Hsieh MH,Chen YJ. Gender modulates the aging effects on different patterns of early repolarization . Heart Vessels. .2014 ;(29):249-55

64. 2014 Kao YH,Chen YC,Lin YK,Shiu RJ,Chao TF,Chen SA, Chen YJ. FGF-23 Dysregulates Calcium Homeostasis and Electrophysiological Properties in HL-1 Atrial Cells. . Eur J Clin Invest. .2014 ;(44):795-801

65. 2014 Lin YK,Chen YC,Kao YH,Tsai CF,Yeh YH,Huang JL, Cheng CC, Chen SA, Chen YJ. A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation . Int J Cardiol. .2014

66. 2014 Tsai WC,Lee TI,Chen YC,Kao YH,Lu YY,Lin YK, Chen SA, Chen YJ. Testosterone replacement increases aged pulmonary vein and left atrium arrhythmogenesis with enhanced adrenergic activity. . Int J Cardiol. .2014

67. 2014 Huang JH,Lin YK,Hsieh MH,Chen SA,Chen YJ. Non-standard dose dronedarone in treating atrial fibrillation patients. . Int J Cardiol. .2014 ;(172):e214-6

68. 2014 Chen WT,Chang SL,Lin YJ,Lo LW,Hu YF,Chao TF, Chung FP, Liao JN, Huang YC, Hsieh MH, Lin YK, Chen YJ, Chen SA, Tsao HM.. The impact of anatomical remodeling of the left atrium and pulmonary vein on the recurrence of paroxysmal atrial fibrillation after catheter ablation. . Int J Cardiol. .2014 ;(176):1173-5

69. 2013 Chang SL,Chen YC,Hsu CP,Kao YH,Lin YK,Lin YJ, Wu TJ, Chen SA, Chen YJ. Electrophysiological characteristics of complex fractionated electrograms and high frequency activity in atrial fibrillation . Int J Cardiol .2013 ;(168):2289-99

70. 2013 Hanafy DA,Chen YC,Chang SL,Lu YY,Lin YK,Kao YH, Chen SA, Chen YJ. Different effects of dronedarone and amiodarone on pulmonary vein lectrophysiology, mechanical properties and H2O2-induced arrhythmogenicity . Eur J Pharmacol. .2013 ;(702):103-108

71. 2013 Chang CJ,Chen YC,Kao YH,Lin YK,Chen SA,Chen YJ. Response to letter regarding article, . Circ Arrhythm Electrophysiol. .2013 ;(6):e23-e23

72. 2013 Chang CJ,Chen YC,Lin YK,Huang JH,Chen SA,Chen YJ. Rivaroxaban modulates electrical and mechanical characteristics of left atrium. . J Biomed Sci. .2013 ;(20):17-17

73. 2013 Yang HY,Chiu WC,Huang JH,Hsu CY,Lin YK,Chen YJ. Analysis of 10-year nationwide population-based data on sex differences in hospitalization for heart failure. . Heart Vessels .2013 ;(28):721-7

74. 2013 Chang SL,Chen YC,Hsu CP,Kao YH,Lin YK,Lai YJ, Yeh HI, Higa S, Chen SA, Chen YJ. Heat shock protein inducer modifies arrhythmogenic substrate and inhibits atrial fibrillation in the failing heart. . Int J Cardiol. .2013 ;(168):4019-26

75. 2013 Tsai WC,Yang LY,Chen YC,Kao YH,Lin YK,Chen SA, Cheng CF, Chen YJ. Ablation of the androgen receptor gene modulates atrial electrophysiology and arrhythmogenesis with calcium protein dysregulation. . Endocrinology. .2013 ;(154):2833-42

76. 2013 Chen WT,Chen YC,Lu YY,Kao YH,Huang JH,Lin YK, Chen SA, Chen YJ.. Apamin modulates electrophysiological characteristics of the pulmonary vein and the sinoatrial node. . Eur J Clin Invest. .2013 ;(43):957-63

77. 2013 Lin YK,Chen YJ. Adipocytokines modulate ionic currents – A key to lipotoxicity potentiated cardiac arrhythmia. . Journal of Arrhythmia. .2013 ;(29):247-248

78. 2013 Lin YK,Chen YC,Huang JH,Lin YJ,Huang SS,Chen SA, Chen YJ. Leptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes. . J Biomed Sci. .2013 ;(20):94

79. 2013 Cheng CC,Weerateerangkul P,Lu YY,Chen YC,Lin YK,Chen SA, Chen YJ. Apelin regulates the electrophysiological characteristics of atrial myocytes . Eur J Clin Invest. .2013 ;(43):34-40

80. 2013 Lin YK,Chen YC,Chang SL,Lin YJ,Chen JH,Yeh YH, Chen SA, Chen YJ. Heart failure epicardial fat increases atrial arrhythmogenesis . Int J Cardiol .2013 ;(167):1979-1983

81. 2012 Lin YK,Chen YC,Chen JH,Chen SA,Chen YJ. Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation. . Basic Res Cardiol. .2012 ;(107):293

82. 2012 Lin YK,Chen YC,Chang SL,Lin YJ,Chen JH,Yeh YH, Chen SA, Chen YJ. Heart failure epicardial fat increases atrial arrhythmogenesis . Int J Cardiol. .2012 ;(Epub):*-*

83. 2012 Lin YK,Lai MS,Chen YC,Cheng CC,Huang JH,Chen SA, Chen YJ, Lin CI.. Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium . Clinical Science (London, England : 1979) .2012 ;(122):121-32

84. 2012 Suenari K,Cheng CC,Chen YC,Lin YK,Nakano Y,Kihara Y, Chen SA, Chen YJ.. Effects of ivabradine on the pulmonary vein electrical activity and modulation of pacemaker currents and calcium homeostasis . Journal of cardiovascular electrophysiology .2012 ;(23):200-206

85. 2012 Tsao HM,Weerateerangkul P,Chen YC,Kao YH,Lin YK,Huang JH, Chen SA, Chen YJ. Amyloid peptide regulates calcium homoeostasis and arrhythmogenesis in pulmonary vein cardiomyocytes . Eur J Clin Invest. .2012 ;(42):589-598

86. 2012 Yang HY,Chiu WC,Huang JH,Hsu CY,Lin YK,Chen YJ. Analysis of 10-year nationwide population-based data on sex differences in hospitalization for heart failure . Heart Vessels. .2012

87. 2012 Chang CJ,Chen YC,Kao YH,Lin YK,Chen SA,Chen YJ. Dabigatran and thrombin modulate electrophysiological characteristics of pulmonary vein and left atrium . Circ Arrhythm Electrophysiol. .2012 ;(5):1176-1183

88. 2011 Lin YK,Chen YC,Cheng CC,Lin FZ,Lin CI,Chen SA, Chen YJ. Interactions of aging and hydrogen peroxide on pulmonary vein electrical activity: implications in the pathophysiology of atrial fibrillation . Acta Cardiol Sin .2011 ;(27):109-114

89. 2011 Lin YK,Chen YC,Chen SA,Chen YJ. Ion Channel Remodeling in Pulmonary Vein Arrhythmogenesis for Atrial Fibrillation . J Exp Clin Med .2011 ;(3):108-111

90. 2011 Chang SL,Chen YC,Yeh YH,Lai YJ,Yeh HI,Lin CI, Lin YK, Lin YJ, Wu TJ, Huang YK, Chen SA, Chen YJ. Heart Failure Enhances Arrhythmogenesis in Pulmonary Veins . Clin Exp Pharmacol Physiol. .2011 ;(38):666-674

91. 2011 Tsai WC,Chen YC,Lin YK,Chen SA,Chen YJ. Gender Differences in the Electrophysiological Characteristics of Pulmonary Veins and Left Atrium and Their Clinical Implication in Atrial Fibrillation . Circ Arrhythm Electrophysiol. .2011 ;(4):550-559

92. 2011 Chang SL,Tsao HM,Lin YJ,Lo LW,Hu YF,Tuan TC, Suenari K, Tai CT, Li CH, Chao TF, Lin YK, Tsai CF, Wu TJ, Chen SA. Characteristics and Significance of Very Early Recurrence of Atrial Fibrillation After Catheter Ablation . J Cardiovasc Electrophysiol. .2011 ;(22):1193-1198

93. 2011 Tseng TW,Hu YF,Tsai CF,Tsao HM,Tai CT,Lin YJ, Chang SL, Lo LW, Lee PC, Li CH, Chao TF, Suenari K, Lin YK, Chiang CE, Chen SA.. Paradoxical Aging Changes of the Atrioventricular Nodal Properties in Patients With Atrioventricular Nodal Re-Entrant Tachycardia . Circ J. .2011 ;(75):1581-1584

94. 2011 Lee TI,Kao YH,Chen YC,Pan NH,Lin YK,Chen YJ. Cardiac peroxisome-proliferator-activated receptor expression in hypertension co-existing with diabetes . Clin Sci (Lond). .2011 ;(121):305-312

95. 2011 Huang SY,Lin YJ,Tsao HM,Chang SL,Lo LW,Hu HF, Suenari K, Lin YK, Huang JH, Chen IC, Ko WC, Ong ET, Chen SA. The biatrial substrate properties in different types of paroxysmal atrial fibrillation . Heart Rhythm .2011 ;(8):961-967

96. 2011 Chung FP,Hu YF,Chao TF,Higa S,Cheng H,Lin YJ, Chang SL, Lo LW, Tuan TC, Tai CT, Li CH, Lin YK, Chen SA. The correlation between ventricular repolarization and clinical severity of spinal cord injuries . Heart Rhythm .2011 ;(8):879-884

97. 2011 Hu YF,Yeh HI,Tsao HM,Tai CT,Lin YJ,Chang SL, Lo LW, Tuan TC, Tzeng CH, Huang SH, Lin YK, Chen SA.. Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation . Heart Rhythm .2011 ;(8):650-656

98. 2011 Suenari K,Chen YC,Kao YH,Cheng CC,Lin YK,Chen YJ, Chen SA. Discrepant electrophysiological characteristics and calcium homeostasis of left atrial anterior and posterior myocytes . Basic Res Cardiol. .2011 ;(106):65-74

99. 2011 Cheng CC,Huang CF,Chen YC,Lin YK,Kao YH,Chen YJ, Chen SA. Heat-stress responses modulate beta-adrenergic agonist and angiotensin II effects on the arrhythmogenesis of pulmonary vein cardiomyocytes . J Cardiovasc Electrophysiol. .2011 ;(22):183-190

100. 2011 Huang JH,Yang HY,Hsu CY,Lin YK,Chen SA,Chen YJ. Gender differences in trend of hospital management for atrial fibrillation: a nationwide population-based analysis . Int J Cardiol. .2011 ;(153):89-94

101. 2011 Tsai CF,Chen YC,Lin YK,Chen SA,Chen YJ. Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium . Basic Res Cardiol. .2011 ;(106):979-993

102. 2011 Huang JH,Lin YK,Hsieh MH,Chen SA,Chen YJ. Thyroxine monotherapy without amiodarone enhances atrial fibrillation recurrences in amiodarone-induced hypothyroidism . Int J Cardiol. .2011 ;(152):277-278

103. 2011 Chang SL,Chen YC,Yeh YH,Lin YK,Wu TJ,Lin CI, Chen SA, Chen YJ. Heart failure enhanced pulmonary vein arrhythmogenesis and dysregulated sodium and calcium homeostasis with increased calcium sparks . J Cardiovasc Electrophysiol. .2011 ;(22):1378-1386

104. 2011 Lee TI,Chen YC,Kao YH,Hsiao FC,Lin YK,Chen YJ. Rosiglitazone induces arrhythmogenesis in diabetic hypertensive rats with calcium handling alteration . Int J Cardiol. .2011

105. 2010 Lin YK,Chen YJ. Research update for articles published in EJCI in 2008- Swelling activated chloride currents in the electrical activity of pulmonary vein cardiomyocytes . Eur J Clin Invest. .2010 ;(40):770-789

106. 2010 Lin YK,Lin FZ,Chen YC,Cheng CC,Lin CI,Chen YJ, Chen SA. Oxidative stress on pulmonary vein and left atrium arrhythmogenesis . Circ J. .2010 ;(74):1547-1556

107. 2010 Lin YK,Chen YJ,Chen SA. Potential atrial arrhythmogenicity of adipocytes: implications for the genesis of atrial fibrillation . Medical hypotheses .2010 ;(74):1026-1029

108. 2010 Lin YK,Lu YY,Chen YC,Chen YJ,Chen SA. Nitroprusside modulates pulmonary vein arrhythmogenic activity . J Biomed Sci. .2010 ;(17):20

109. 2006 Hsieh MH,Tai CT,Lee SH,Lin YK,Tsao HM,Chang SL, Lin YJ, Wongchaoen W, Lee KT, Chen SA. The different mechanisms between late and very late recurrences of atrial fibrillation in patients undergoing a repeated catheter ablation . J Cardiovasc Electrophysiol .2006 ;(17):231-5

110. 2005 Tsao HM,Wu MH,Huang BH,Lee SH,Lee KT,Tai CT, Lin YK, Hsieh MH, Kuo JY, Lei MH, Chen SA. Morphologic remodeling of pulmonary veins and left atrium after catheter ablation of atrial fibrillation: insight from long-term follow-up of three-dimensional magnetic resonance imaging . J Cardiovasc Electrophysiol. .2005 ;(16):7-12

111. 2005 Hsieh MH,Tai CT,Lee SH,Tsao HM,Lin YK,Huang JL, Chan P, Chen YJ, Kuo JY, Tuan TC, Hsu TL, Kong CW, Chang SL, Chen SA. Catheter ablation of atrial fibrillation versus atrioventricular junction ablation plus pacing therapy for elderly patients with medically refractory paroxysmal atrial fibrillation . J Cardiovasc Electrophysiol. .2005 ;(16):457-61

112. 2004 Lee SH,Tai CT,Hsieh MH,Tsai CF,Lin YK,Tsao HM, Yu WC, Huang JL, Ueng KC, Cheng JJ, Ding YA, Chen SA. Predictors of early and late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation . J Interv Card Electrophysiol. .2004 ;(10):221-6

113. 2004 Pan JP,Liu TY,Chiang SC,Lin YK,Chou CY,Chan WL, Lai ST. The value of plasma levels of tumor necrosis factor-alpha and interleukin-6 in predicting the severity and prognosis in patients with congestive heart failure . J Chin Med Assoc. .2004 ;(67):222-8

114. 2003 Kuo JY,Tai CT,Tsao HM,Hsieh MH,Tsai CF,Lin WS, Lin YK, Ding YA, Hou CJ, Tsai CH, Chen SA. P wave polarities of an arrhythmogenic focus in patients with paroxysmal atrial fibrillation originating from superior vena cava or right superior pulmonary vein . J Cardiovasc Electrophysiol. .2003 ;(14):350-7

115. 2003 Wu CC,Hsieh MH,Tai CT,Chiang CE,Yu WC,Lin YK, Tsao HM, Ding YA, Chen SA. Utility of patient-activated cardiac event recorders in the detection of cardiac arrhythmias . J Interv Card Electrophysiol. .2003 ;(8):117-20

116. 2003 Lin WS,Tai CT,Hsieh MH,Tsai CF,Lin YK,Tsao HM, Huang JL, Yu WC, Yang SP, Ding YA, Chang MS, Chen SA. Catheter ablation of paroxysmal atrial fibrillation initiated by non-pulmonary vein ectopy . Circulation .2003 ;(107):3176-83

117. 2003 Hsieh MH,Tai CT,Tsai CF,Lin WS,Lin YK,Tsao HM, Huang JL, Ueng KC, Yu WC, Chan P, Ding YA, Chang MS, Chen SA. Clinical outcome of very late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation. . J Cardiovasc Electrophysiol. .2003 ;(14):598-601

118. 2003 Tuan TC,Tai CT,Lin YK,Hsieh MH,Tsai CF,Ding YA, Chen SA. Use of fluoroscopic views for detecting Marshall's vein in patients with cardiac arrhythmias . J Interv Card Electrophysiol .2003 ;(9):327-31

119. 2003 Tai CT,Lin YK,Lan FC,Chen HY,Ding YA,Chang MS, Chen SA. Conduction properties of the crista terminalis in patients with atrial flutter due to amiodarone therapy for atrial fibrillation . Pacing Clin Electrophysiol. .2003 ;(26):2241-6

120. 2002 Tai CT,Haque A,Lin YK,Tsao HM,Ding YA,Chang MS, Chen SA. Double potential interval and transisthmus conduction time for prediction of cavotricuspid isthmus block after ablation of typical atrial flutter . J Interv Card Electrophysiol. .2002 ;(7):77-82

121. 2002 Tai CT,Huang JL,Lin YK,Hsieh MH,Lee PC,Ding YA, Chang MS, Chen SA. Noncontact three-dimensional mapping and ablation of upper loop re-entry originating in the right atrium . J Am Coll Cardiol. .2002 ;(40):746-53

122. 2001 Wu CC,Tai CT,Lin YK,Tsao HM,Yu WC,Chen SA. Pulmonary vein dissection during mapping of atrial fibrillation. . J Cardiovasc Electrophysiol .2001 ;(12):505-505

123. 2001 Kuo JY,Tai CT,Tsao HM,Lin YK,Chen SA. A regular narrow QRS complex tachycardia with atrioventricular dissociation. . Pacing Clin Electrophysiol. .2001 ;(24):1150-1

124. 2001 Lu TM,Tai CT,Hsieh MH,Tsai CF,Lin YK,Yu WC, Tsao HM, Lee SH, Ding YA, Chang MS, Chen SA. Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area . J Am Coll Cardiol. .2001 ;(37):1658-64

125. 2001 Kuo JY,Tai CT,Lin YK,Tsao HM,Chen SA. Bidirectional ventricular tachycardia after radiofrequency ablation of idiopathic left ventricular tachycardia. . Pacing Clin Electrophysiol. .2001 ;(24):1412-4

126. 2001 Yu WC,Hsu TL,Tai CT,Hsieh MH,Lu TM,Lin YK, Tsao HM, Ding YA, Chang MS, Chen SA. Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation . J Cardiovasc Electrophysiol. .2001 ;(12):887-92

127. 2001 Tai CT,Lin YK,Chen SA. Atypical atrial flutter involving the isthmus between the right pulmonary veins and fossa ovalis . Pacing Clin Electrophysiol. .2001 ;(24):384-7

128. 2001 Tsao HM,Wu MH,Yu WC,Tai CT,Lin YK,Hsieh MH, Ding YA, Chang MS, Chen SA. Role of right middle pulmonary vein in patients with paroxysmal atrial fibrillation. . J Cardiovasc Electrophysiol. .2001 ;(12):1353-7

129. 2001 Kuo JY,Tai CT,Chiang CE,Yu WC,Chen YJ,Tsai CF, Chen CC, Lin WS, Lin YK, Tsao HM, Ding YA, Chang MS, Chen SA. Mechanisms of transition between double paroxysmal supraventricular tachycardias . J Cardiovasc Electrophysiol. .2001 ;(12):1339-45

130. 2000 Lin WS,Prakash VS,Tai CT,Hsieh MH,Tsai CF,Yu WC, Lin YK, Ding YA, Chang MS, Chen SA. Pulmonary Vein Morphology in Patients with Paroxysmal Atrial Fibrillation Initiated by Ectopic Beats Originating from Pulmonary Veins - Implication for Catheter Ablation . Circulation. .2000 ;(101):1274-81

131. 2000 Hsieh MH,Tai CT,Tsai CF,Yu WC,Lee SH,Lin YK, Ding YA, Chang MS, Chen SA. Pulmonary vein electrogram characteristics in patients with focal source of paroxysmal atrial fibrillation. . J Cardiovasc Electrophysiol. .2000 ;(11):953-9

132. 2000 Lee SH,Tai CT,Lin WS,Tsai CF,Hsieh MH,Yu WC, Lin YK, Chen CC, Ding YA, Chang MS, Chen SA. Predicting the arrhythmogenic foci of atrial fibrillation before atrial transseptal procedure: implication for catheter ablation. . J Cardiovasc Electrophysiol. .2000 ;(11):750-7

133. 1999 Yu WC,Lin YK,Tai CT,Tsai CF,Hsieh MH,Chen CC, Hsu TL, Ding YA, Chang MS, Chen SA. Early recurrence of atrial fibrillation after external cardioversion. . Pacing Clin Electrophysiol. .1999 ;(22):1614-9

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