楊文賓(Yang Wen-Bin) 助理教授

Email
wenbinyang@tmu.edu.tw
現   職
神經醫學博士學位學程 助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立成功大學生物資訊與訊息傳遞研究所 博士
2009/09~2014/12
國立成功大學生物資訊研究所 碩士
2007/09~2009/06
國立嘉義大學生物農業科技學系 學士
2003/09~2007/06

本校學術經歷

任職單位與職稱[起迄時間]
神經醫學博士學位學程助理教授
2024/02/01~
神經醫學研究中心助理研究員
2021/06/01~2024/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
臺北醫學大學博士後研究員
2017/04/01~2021/05/31
國立交通大學博士後研究員
2016/03/02~2017/03/31
國家衛生研究院博士後研究員
2015/03/02~2016/03/01

專長與研究領域

學門領域
藥理及毒理
Pharmacology and Toxicology
醫學生化及分子生物
Medical Biochemistry and Molecular Biology
學術專長
分子及細胞生物學
分子及細胞生物學
生物資訊
生物資訊
細胞訊息傳遞
細胞訊息傳遞
癌症基因體學
癌症基因體學
癌症細胞生物學
癌症細胞生物學

論文著作

清冊下載


1. 2024 Sachin S,Wang SA,Yang WB,Lin HY,Lai MJ,Chen HC, Kao TY, Hsu FL, Nepali K, Hsu TI, Liou JP. First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo . Journal of Medicinal Chemistry .2024 ;(67):2963-2985

2. 2024 Sharma R,Chiang YH,Chen HC,Lin HY,Yang WB,Nepali K, Lai MJ, Chen KY, Liou JP, Hsu TI. Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress . Cancer Letters .2024 ;(586)

3. 2024 Liu CC,Yang WB,Chien CH,Wu CL,Chuang JY,Chen PY, Chu JM, Cheng SM, Qiu LY, Chang YC, Hwang DY, Huang CY, Lee JS, Chang KY. CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity . Cell Death & Disease .2024 ;(15)

4. 2023 Kao TJ,Lin CL,Yang WB,Li HY,Hsu TI. Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities . Lipids in Health and Disease .2023 ;(22)

5. 2022 Young MJ,Chen YC,Wang SA,Chang HP,Yang WB,Lee CC, Liu CY, Tseng YL, Wang YC, Sun HS, Chang WC, Hung JJ. Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression . JOURNAL OF BIOMEDICAL SCIENCE .2022 ;(29)

6. 2022 Wu AC,Yang WB,Chang KY,Lee JS,Liou JP,Su RY, Cheng SM, Hwang DY, Kikkawa U, Hsu TI, Wang CY, Chang WC, Chen PY, Chuang JY. HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells . JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH .2022 ;(41)

7. 2022 Tsai YT,Lo WL,Chen PY,Ko CY,Chuang JY,Kao TJ, Yang WB, Chang KY, Hung CY, Kikkawa U, Chang WC, Hsu TI. Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation . JOURNAL OF BIOMEDICAL SCIENCE .2022 ;(29)

8. 2022 Chien CH,Yang WB,Chuang JY,Lee JS,Liao WA,Huang CY, Chen PY, Wu AC, Yang ST, Lai CC, Chi PI, Chu JM, Cheng SM, Liu CC, Hwang DY, Chen SH, Chang KY. SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma . JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH .2022 ;(41)

9. 2022 Lin HY,Lim SW,Hsu TI,Yang WB,Huang CC,Tsai YT, Chang WC, Ko CY. CCAAT/enhancer-binding protein delta regulates glioblastoma survival through catalase-mediated hydrogen peroxide clearance . OXIDATIVE MEDICINE AND CELLULAR LONGEVITY .2022 ;(2022)

10. 2021 Yang WB,Wu AC,Hsu TI,Liou JP,Lo WL,Chang KY, Chen PY, Kikkawa U, Yang ST, Kao TJ, Chen RM, Chang WC, Ko CY, Chuang JY. Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells . CELL DEATH & DISEASE .2021 ;(12)

11. 2020 Lo WL,Hsu TI,Yang WB,Kao TJ,Wu MH,Huang YN, Yeh SH, Chuang JY. Betulinic Acid-Mediated Tuning of PERK/CHOP Signaling by Sp1 Inhibition as a Novel Therapeutic Strategy for Glioblastoma . CANCERS .2020 ;(12)

12. 2020 Yang, WB,Hsu, CC,Hsu, TI,Liou, JP,Chang, KY,Chen PY, Liu JJ, Yang ST, Wang JY, Yeh SH, Chen RM, Chang WC, Chuang JY. Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma . NEURO-ONCOLOGY .2020 ;(22):1439-1451

13. 2020 You MS,Yang WB,Cheng CH,Yu S,Chang HC,Yu HS. Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish . JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY .2020 ;(213)

14. 2019 Yang WB,Chuang JY,Ko CY,Chang WC,Chang TI. Dehydroepiandrosterone Induces Temozolomide Resistance Through Modulating Phosphorylation and Acetylation of Sp1 in Glioblastoma . MOLECULAR NEUROBIOLOGY .2019 ;(56):2301-2313

15. 2019 Lin HY,Ko CY,Kao TJ ,Yang WB,Tsai YT ,Chuang JY, Hu SL, Yang PY, Lo WL, Hsu TI . CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis . CANCERS .2019 ;(11)

16. 2019 Chien CH,Chuang JY,Yang ST,Yang WB,Chen PY,Hsu TI, Huang CY, Lo WL, Yang KY, Liu MS, Chu JM, Chung PH , Liu JJ, Chou SW, Chen SH, Chang KY. Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets . JOURNAL OF BIOMEDICAL SCIENCE .2019 ;(26)

17. 2019 Tsai YT,Wu AC,Yang WB,Kao TJ,Chuang JY,Chang WC, Hsu TI. ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2019 ;(20)

18. 2016 Wang YC,Wang SA,Chen PH,Hsu TI,Yang WB,Chuang YP, Su WC, Liaw HJ, Chang WC, Hung JJ. Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy . ONCOGENE .2016 ;(35):3669-3680

19. 2016 Su WP,Hsu SH,Chia LC,Lin JY,Chang SB,Jiang ZD, Lin YJ, Shih MY, Chen YC, Chang MS, Yang WB, Hung JJ, Hung PC, Wu WS, Myung K, Liaw H. Combined interactions of plant homeodomain and chromodomain regulate NuA4 activity at DNA double-strand breaks . GENETICS .2016 ;(202):77-92

20. 2014 Hung CY,Yang WB,Wang SA,Hsu TI,Chang WC,Hung JJ. Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis . BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH .2014 ;(1843):2843-2854

21. 2014 Su WP,Hsu SH,Wu CK,Chang SB,Lin YJ,Yang WB, Hung JJ, Chiu WT, Tzeng SF, Tseng YL, Chang JY, Su WC, Liaw HJ. Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma . ONCOTARGET .2014 ;(5):6323-6337

22. 2014 Yang WB,Chen PH,Hsu TI,Fu TF,Su WC,Liaw H, Chang WC, Hung JJ. Sp1-mediated microRNA-182 expression regulates lung cancer progression . ONCOTARGET .2014 ;(5):740-753

23. 2012 Chuang, JY,Wang, SA,Yang, WB,Yang, HC,Hung, CY,Su TP, Chang WC, Hung JJ. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells . ONCOGENE .2012 ;(31):4946-4959

24. 2011 Wang YT,Yang WB,Chang WC,Hung JJ. Interplay of Posttranslational Modifications in Sp1 Mediates Sp1 Stability during Cell Cycle Progression . JOURNAL OF MOLECULAR BIOLOGY .2011 ;(414):1-14

25. 2011 Yeh SH,Yang WB,Gean PW,Hsu CY,Tseng JT,Su TP, Chang WC, Hung JJ. Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway . NUCLEIC ACIDS RESEARCH .2011 ;(39):5412-5423

26. 2008 Wang YT,Chuang JY,Shen MR,Yang WB,Chang WC,Hung JJ. Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process . JOURNAL OF MOLECULAR BIOLOGY .2008 ;(380):869-885

研究計畫

計畫名稱
113 釐清γ-氨基丁酸介導的膠質母細胞瘤中與帝盟多抗藥性相關的表觀遺傳變化(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
110 釐清麩胺酸介導γ-氨基丁酸的訊號傳遞在復發性膠質母細胞瘤中扮演的角色
補助單位
國家科學及技術委員會