謝尚逸(Yves Hsieh) 教授

Email
yvhsieh@tmu.edu.tw
現   職
藥物科學學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
雪梨大學化學系 博士
2009/02~2013/11
奧克蘭大學生命科學系 碩士
2004/01~2006/02
奧克蘭大學生命科學系 學士
1999/02~2003/11

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科教授
2024/02/01~
藥物科學學科副教授
2020/08/01~2024/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
中草藥臨床藥物研發博士學位學程副教授
2023/07/01 ~
新藥研發產業博士學位學程副教授
2023/07/01 ~
生藥學研究所副教授
2021/04/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院基因體中心訪問副教授
瑞典皇家理工學院專任副教授
2019/12/01~2020/07/01
瑞典皇家理工學院助理教授
2016/02/01~2019/11/30
阿德雷大學博士後研究員
2013/10/01~2016/01/31

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2024 Ta-Wei Liu,Su-Jung Hsu,Yves S.Y. Hsieh,Hui-Kang Liu,Ching-Kuo Lee. Polymethoxyflavone from Citrus depressa as an inhibitor against various variants of SARS-CoV-2 spike protein . Journal of Ethnopharmacology .2024 ;(320):117412-117412

2. 2024 Tzu-Yin Chen,Eileen Shyur,Tzu-Hsuan Ma,Lakshmi Wijeyewickrema,Sheng-Wei Lin,Mu-Rong Kao, Pi-Hui Liang, Jiun-Jie Shie, Er-Yuan Chuang, Jing-Ping Liou, Yves SY Hsieh. Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech-Derived Peptides on Binding and Inhibitory Activity Against Thrombin . ChemBioChem .2024

3. 2024 Mu-Rong Kao ,Rebecka Karmarkar Saldivar,Yves S.Y. Hsieh . Production of therapeutic glycoproteins in glycoengineered plant: old farm for new crops . Current Opinion in Biotechnology .2024 ;(87):103145-103145

4. 2024 Mu-Rong Kao,Jake Parker,Daniel Oehme,Shu-Chieh Chan,Lin-Chen Cheng,Damao Wang, Vaibhav Srivastava, John M. Wagner, Philip J. Harris, Yves S. Y. Hsieh. Substrate Specificities of Variants of Barley (1,3)- and (1,3;1,4)-β-d-Glucanases Resulting from Mutagenesis and Segment Hybridization . Biochemistry .2024 ;(63):1194-1205

5. 2024 Yves S.Y. Hsieh ,Mu-Rong Kao,Matthew R. Tucker. The knowns and unknowns of callose biosynthesis in terrestrial plants . Carbohydrate Research .2024 ;(538):109103-109103

6. 2024 Shu-Chieh Chang,Rebecka Karmakar Saldivar,Mu-Rong Kao ,Xiaohui Xing ,Chun-Hong Yeh ,Jiun-Jie Shie, D. Wade Abbott, Philip J. Harris, Yves S.Y. Hsieh. Two glycosyl transferase 2 genes from the gram-positive bacterium Clostridium ventriculi encode (1,3;1,4)-β-D-glucan synthases . Carbohydrate Polymers .2024 ;(342):122394-122394

7. 2024 Xiaohui Xing,Kanglin Xing, ,Yves S.Y. Hsieh,D. Wade Abbott . Inequality relations for NMR-based polymer homoblock analysis and extended application: Reanalysis of historical data on alginates, chitosans, homogalacturonans, and galactomannans . Carbohydrate Research .2024 ;(542):109189-109189

8. 2024 Mu-Rong Kao,Tzu-Hsuan Ma,Hsiang-Yu Chou,Shu-Chieh Chang,Lin-Chen Cheng,Kuo-Shiang Liao, Jiun-Jie Shie, Philip J Harris, Chi-Huey Wong, Yves SY Hsieh . A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies . ACS Chemical Biology .2024 ;(19):1515-1524

9. 2024 Ilaria Marcotuli,Xiaohui Xing,Davide Caranfa,Stefania L. Giove,Yves S.Y. Hsieh,Shu-Chieh Chang, D. Wade Abbott, Agata Gadaleta. Is the CslF6 gene involved in the accumulation of (1,3;1,4)-β-D-glucan in wheats, their wild relatives and their hybrids? . Food Chemistry: Molecular Sciences .2024

10. 2024 Pei-Wei Weng,Chia-Hung Liu,Pei-Ru Jheng,Chia-Che Chiang,Yan-Ting Chen,Lekshmi Rethi, Yves S. Y. Hsieh, Andrew E.-Y. Chuang . Spermatozoon-propelled microcellular submarines combining innate magnetic hyperthermia with derived nanotherapies for thrombolysis and ischemia mitigation . Journal of Nanobiotechnology .2024 ;(22)

11. 2024 Ta-Wei Liu,Benni Iskandar,Man-Hsiu Chu,Yun-Han Wang,Ting-An Huang,Su-Jung Hsu, Yves SY Hsieh, Ching-Kuo Lee . Dynamic changes in the metabolome and microbiome during Citrus depressa Hayata liquid fermentation . Food Chemistry .2024

12. 2023 SY Hsiung,Jing Li,Balazs Imre,Mu-Rong Kao,Hsien-Chun Liao,Damao Wang, Chih-Hui Chen, Pi-Hui Liang, Philip J. Harris, Yves S.Y. Hsieh. Structures of the xyloglucans in the monocotyledon family Araceae (aroids) . Planta .2023 ;(257):39

13. 2023 Chiu Pei-Fang,Lin I-Chun,Lu Yeh-Lin,Chang Chiao-Nien,Chan Hui-Yu,Lin Tzung-Shen,Tsai Keng-Chang,S. Y. Hsieh Yves,Chen Mei-Jou,Lin Mei-Hsiang,Liang Pi-Hui. Design, Structure–Activity Relationships, and Enzyme Kinetic Studies of Tricyclic and Tetracyclic Coumarin–based Sulfamates as Steroid Sulfatase Inhibitors . Bioorganic Chemistry .2023 ;(138)

14. 2023 Yixuan Zhou,Kuo-Shiang Liao,Tzu-Yin Chen,Yves S Y Hsieh,Chi-Huey Wong. Effective Organotin-Mediated Regioselective Functionalization of Unprotected Carbohydrates . Journal of Organic Chemistry .2023

15. 2023 Gyu Hwan Hyun,Da-Hye Jeong,Yoon Young Yang,In Ho Cho,Yu-Jin Ha,Xiaohui Xing, D. Wade Abbott, Yves S.Y. Hsieh, Yun Pyo Kang, Jong-Ho Cha, Soon-Sun Hong, Seul Ji Lee, You-Sun Kim, Sung Won Kwon. Multivalent Carbohydrate Nanocomposites for Tumor Microenvironment Remodeling to Enhance Anti-tumor Immunity . ACS Nano .2023 ;(17):11567-11582

16. 2023 Meiling Dan,Yuting Zheng,Guohua Zhao,Yves S Y Hsieh,Damao Wang. Current insights of factors interfering the stability of lytic polysaccharide monooxygenases . Biotechnology Advances .2023 ;(67):108216-108216

17. 2023 Shu-Chieh Chang,Mu-Rong Kao, Rebecka Karmakar Saldivar,Sara M. Díaz-Moreno,Xiaohui Xing,Valentina Furlanetto , Johannes Yayo, Christina Divne, Francisco Vilaplana, D. Wade Abbott, Yves S. Y. Hsieh. The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-D-glucans . Nature Communications .2023 ;(14): 4526- 4526

18. 2023 Yan-Ting Chen,Chia-Hung Liu,Wen-Yu Pan,Pei-Ru Jheng,Yves S. Y. Hsieh,Thierry Burnouf, Yu-Jui Fan, Jia-Wei Chiang, Tzu-Yin Chen, Er-Yuan Chuang. Biomimetic Platelet Nanomotors for Site-Specific Thrombolysis and Ischemic Injury Alleviation . ACS applied materials & interfaces .2023

19. 2023 Shih-Yi Hsiung,Shun-Xin Deng,Jing Li,Sheng-Yao Huang,Chen-Kun Liaw,Su-Yun Huang, Ching-Chiung Wang, Yves S.Y. Hsieh. Machine learning-based monosaccharide profiling for tissue-specific classification of Wolfiporia extensa samples . Carbohydrate Polymers .2023

20. 2022 Yuting Zheng,Yanping Li,Yuanyuan Yang,Ye Zhang,Di Wang,Peiyao Wang, Ann CY Wong, Yves SY Hsieh, Damao Wang. Recent Advances in Bioutilization of Marine Macroalgae Carbohydrates: Degradation, Metabolism, and Fermentation . Journal of Agricultural and Food Chemistry .2022 ;(70):1438-1453

21. 2022 Damao Wang,Mu-Rong Kao,Jing Li,Peicheng Sun,Qijun Meng,Anisha Vyas, Pi-Hui Liang, Yane-Shih Wang, Yves S. Y. Hsieh. Novel Two-Step Process in Cellulose Depolymerization: Hematite- Mediated Photocatalysis by Lytic Polysaccharide Monooxygenase and Fenton Reaction . Journal of Agricultural and Food Chemistry .2022 ;(70):9941-9947

22. 2022 Hyunsu Kim,Jing Li,Yves S. Y. Hsieh,Maenghyo Cho,Sung-Hoon Ahn,Chenzhe Li. Photo-Programmed Deformations in Rigid Liquid Crystalline Polymers Triggered by Body Temperature . Small .2022

23. 2022 Jing Li,Shih-Yi Hsiung,Murong Kao,Xiaohui Xing,Shu-Chieh Chang,Damao Wang, Pei-Yun Hsieh, Pi-Hui Liang, Zaibiao Zhu, Ting-Jen Rachel Cheng, Jiun-Jie Shie, Jing-Ping Liou, D Wade Abbott, Sung Won Kwon, Yves SY Hsieh. Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce . Carbohydrate Research .2022 ;(521)

24. 2022 Chiao-Nien Chang,I-Chun Lin,Tzung-Sheng Lin,Pei-Fang Chiu,Yeh-Lin Lu,Manmath Narwane, I-Chen Liu, Yue Hng, Keng-Chang Tsai, Mei-Hsiang Lin, Yves S. Y. Hsieh, Mei-Jou Chen, Pi-Hui Liang. The Design, Structure–Activity, and Kinetic Studies of 3-Benzyl-5- oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl Sulfamates as Steroid Sulfatase Inhibitors . Bioorganic Chemistry .2022 ;(129)

25. 2021 Jing Li,Damao Wang,Shu-Chieh Chang,Pi-Hui Liang,Vaibhav Srivastava, Shih-Yun Guu, Jiun-Jie Shie, Kay-Hooi Khoo, Vincent Bulone, Yves S. Y. Hsieh. Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli . Journal of Agricultural and Food Chemistry .2021

26. 2021 Damao Wang,Yanping Lo,Y Zheng,Yves SY Hsieh. Recent Advances in Screening Methods for the Functional Investigation of Lytic Polysaccharide Monooxygenases . Frontiers in Chemistry .2021

27. 2021 Shu-Chieh Chang,Rebecka Karmakar Saldivar,Pi-Hui Liang,Yves SY Hsieh. Structures, biosynthesis, and physiological functions of (1,3;1,4)-β-D-glucans . Cells .2021 ;( 10):510

28. 2021 Yanping Li,Yuting Zheng,Ye Zhang,Yuanyuan Yang,Peiyao Wang,Balázs Imre, Ann C. Y. Wong, Yves S. Y. Hsieh, Damao Wang. Brown Algae Carbohydrates: Structures, Pharmaceutical Properties, and Research Challenges . Marine Drugs .2021 ;(19)

29. 2020 Lin Tzung Sheng,Hsieh Chang Hsun,Kuo Chin,Juang Yu Pu,Hsieh Yves S.Y.,Chiang Hongsen,Hung Shang Cheng,Jiang Ching Chuan,Liang Pi Hui.. Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate . Carbohydrate Polymers .2020 ;(229):115496

30. 2020 Juang Yu Pu,Lin You Yu,Chan She Hung,Chang Chun Kai,Shie Jiun Jie,Hsieh Yves S.Y.,Guh Jih Hwa,Liang Pi Hui.. Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins . Bioorganic Chemistry .2020 ;(99):103835

31. 2020 Marcotuli Ilaria,Colasuonno Pasqualina,Hsieh Yves S.Y.,Fincher Geoffrey B.,Gadaleta Agata. Non-starch polysaccharides in durum wheat: A review . International Journal of Molecular Sciences .2020 ;(21):2933

32. 2020 Hyung Min Kim, Yanxue Song, Gyu Hwan Hyun, Nguyen Phuoc Long, Nguyen Phuoc Long, Jeong Hill Park,Yves S.Y. Hsieh, Sung Won Kwon. Characterization and Antioxidant Activity Determination of Neutral and Acidic Polysaccharides from Panax Ginseng C. A. Meyer . Molecules .2020 ;(25):791

33. 2019 Li Jing,Wang Damao,Xing Xiaohui,Cheng Ting Jen Rachel,Liang Pi Hui,Bulone Vincent,Park Jeong Hill,Hsieh Yves S.Y.. Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc . International Journal of Biological Macromolecules .2019 ;(135):29-37

34. 2019 Hsieh Yves S.Y.,Harris Philip J.. Xylans of red and green algae: What is known about their structures and how they are synthesised? . Polymers .2019 ;(11):354

35. 2019 Pham Trang A.T.,Schwerdt Julian G.,Shirley Neil J.,Xing Xiaohui,Hsieh Yves S.Y.,Srivastava Vaibhav,Bulone Vincent,Little Alan.. Analysis of cell wall synthesis and metabolism during early germination of Blumeria graminis f. sp. hordei conidial cells induced in vitro . The Cell Surface .2019 ;(5):100030

36. 2018 Roberts Alison W.,Lahnstein Jelle,Hsieh Yves S.Y.,Xing Xiaohui,Yap Kuok,Chaves Arielle M.,Scavuzzo-Duggan Tess R.,Dimitroff George,Lonsdale Andrew,Roberts Eric,Bulone Vincent,Fincher Geoffrey B.,Doblin Monika S.,Bacic Antony,Burton Rachel A.. Functional characterization of a glycosyltransferase from the moss physcomitrella patens involved in the biosynthesis of a novel cell wall arabinoglucan . The Plant Cell .2018 ;(30):1293-1308

37. 2018 Wang Damao,Aarstad Olav A.,Li Jing,McKee Lauren S.,Sætrom Gerd Inger,Vyas Anisha,Srivastava Vaibhav,Aachmann Finn L.,Bulone Vincent,Hsieh Yves Sy.. Preparation of 4-Deoxy- L -erythro-5-hexoseulose Uronic Acid (DEH) and Guluronic Acid Rich Alginate Using a Unique exo-Alginate Lyase from Thalassotalea crassostreae . Journal of Agricultural and Food Chemistry .2018 ;(66):1435-1443

38. 2018 Wang Damao,Li Jing,Salazar-Alvarez Germán,McKee Lauren S.,Srivastava Vaibhav,Sellberg Jonas A.,Bulone Vincent,Hsieh Yves S.Y.. Production of functionalised chitins assisted by fungal lytic polysaccharide monooxygenase . Green Chemistry .2018 ;(20):2091-2100

39. 2018 Wang Damao,Li Jing,Wong Ann C.Y.,Aachmann Finn L.,Hsieh Yves S.Y.. A colorimetric assay to rapidly determine the activities of lytic polysaccharide monooxygenases . Biotechnology for Biofuels .2018 ;(11)

40. 2017 Xing Xiaohui,Hsieh Yves S.Y.,Yap Kuok,Ang Main E.,Lahnstein Jelle,Tucker Matthew R.,Burton Rachel A.,Bulone Vincent.. Isolation and structural elucidation by 2D NMR of planteose, a major oligosaccharide in the mucilage of chia (Salvia hispanica L.) seeds . Carbohydrate Polymers .2017 ;(175):231-240

41. 2016 Hsieh Yves S.Y.,Zhang Qisen,Yap Kuok,Shirley Neil J.,Lahnstein Jelle,Nelson Clark J.,Burton Rachel A.,Millar A. Harvey,Bulone Vincent,Fincher Geoffrey B.. Genetics, Transcriptional Profiles, and Catalytic Properties of the UDP-Arabinose Mutase Family from Barley . Biochemistry .2016 ;(55):322-334

42. 2016 Marcotuli Ilaria,Hsieh Yves S.Y.,Lahnstein Jelle,Yap Kuok,Burton Rachel Anita,Blanco Antonio,Fincher Geoffrey Bruce,Gadaleta Agata. Structural Variation and Content of Arabinoxylans in Endosperm and Bran of Durum Wheat (Triticum turgidum L.) . Journal of Agricultural and Food Chemistry .2016 ;(64):2883-2892

43. 2015 Corbin Kendall R.,Hsieh Yves S.Y.,Betts Natalie S.,Byrt Caitlin S.,Henderson Marilyn,Stork Jozsef,DeBolt Seth,Fincher Geoffrey B.,Burton Rachel A.. Grape marc as a source of carbohydrates for bioethanol: Chemical composition, pre-treatment and saccharification . Bioresource Technology .2015 ;(193):76-83

44. 2014 Hsieh Yves S.Y.,Wijeyewickrema Lakshmi C.,Wilkinson Brendan L.,Pike Robert N.,Payne Richard J.. Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein . Angewandte Chemie - International Edition .2014 ;(126):4028-4032

45. 2013 Liao Shih Fen,Liang Chi Hui,Ho Ming Yi,Hsu Tsui Ling,Tsai Tsung I.,Hsieh Yves S.Y.,Tsai Chih Ming,Li Shiou Ting,Cheng Yang Yu,Tsao Shu Ming,Lin Tung Yi,Lin Zong Yan,Yang Wen Bin,Ren Chien Tai,Lin Kuo I.,Khoo Kay Hooi,Lin Chun Hung,Hsu Hsien Yeh,Wu Chung Yi,Wong Chi Huey.. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes . Proceedings of the National Academy of Sciences of the United States of America .2013 ;(110):13809-13814

46. 2013 Wong Ann C Y,Froud Kristina E.,Hsieh Yves S.-Y.. Noise-induced hearing loss in the 21 century: A research and translational update . World Journal of Otorhinolaryngology .2013 ;(3):58-70

47. 2012 Hsieh Yves S.Y.,Taleski Deni,Wilkinson Brendan L.,Wijeyewickrem Lakshmi C.,Adams Ty E.,Pike Robert N.,Payne Richard J.. Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin . Chemical Communications .2012 ;(48):1547-1549

48. 2012 Hsieh Yves S.Y.,Wilkinson Brendan L.,O'Connell Mitchell R.,MacKay Joel P.,Matthews Jacqueline M.,Payne Richard J.. Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants . Organic Letters .2012 ;(14):1910-1913

49. 2012 Hsieh Yves S.Y.,Harris Philip J.. Structures of xyloglucans in primary cell walls of gymnosperms, monilophytes (ferns sensu lato) and lycophytes . Phytochemistry .2012 ;(79):87-101

50. 2011 Thomas Gemma L.,Hsieh Yves S.Y.,Chun Candy K.Y.,Cai Zheng Li,Reimers Jeffrey R.,Payne Richard J.. Peptide ligations accelerated by N-terminal aspartate and glutamate residues . Organic Letters .2011 ;(13):4770-4773

51. 2010 Hsieh Yves S.Y.,Wong Chi Yan. Composition of polysaccharides in primary walls of Litchi Chinensis Sonn . Journal of Food Biochemistry .2010 ;(34):971-982

52. 2009 Hsieh Yves S.Y.,Liao Shih Fen,Yang Wen Bin. Biologically active polysaccharides in medicinal plants . New Zealand Journal of Forestry Science .2009 ;(39):217-233

53. 2009 Hsieh Yves S.Y.,Paxton Maree,Ade Carsten P.,Harris Philip J.. Structural diversity, functions and biosynthesis of xyloglucans in angiosperm cell walls . New Zealand Journal of Forestry Science .2009 ;(39):187-196

54. 2009 Hsieh Yves S.Y.,Harris Philip J.. Xyloglucans of monocotyledons have diverse structures . Molecular Plant .2009 ;(2):943-965

55. 2008 Hsieh Yves S.Y.,Chien Cheng,Liao Sylvian K.S.,Liao Shih Fen,Hung Wei Ting,Yang Wen Bin,Lin Chih Chien,Cheng Ting Jen Rachel,Chang Chia Chuan,Fang Jim Min,Wong Chi Huey,Hsieh Yves S.Y.,Chien Cheng,Liao Sylvian K.S.,Liao Shih Fen,Hung Wei Ting,Yang Wen Bin,Lin Chih Chien,Cheng Ting Jen Rachel,Chang Chia Chuan,Fang Jim Min,Wong Chi Huey. Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense . Bioorganic and Medicinal Chemistry .2008 ;(16):6054-6068

研究計畫

計畫名稱
113 化學合成癌症相關之醣蛋白(5/5)
補助單位
國家科學及技術委員會

計畫名稱
112 化學合成癌症相關之醣蛋白(4/5)
補助單位
國家科學及技術委員會

計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費用補助案(研究生:藥學系(所)博士班熊師怡君)
補助單位
國家科學及技術委員會

計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費用補助案(研究生:藥學系(所)博士班Rebecka Karmakar Saldivar君),業經核定,請查照辦理。
補助單位
國家科學及技術委員會

計畫名稱
111 Remodeling of N-glycosylated therapeutic glycoprotein by core- fucose specific endo- and exoglycosida
補助單位
國家科學及技術委員會

計畫名稱
111 化學合成癌症相關之醣蛋白(3/5)
補助單位
國家科學及技術委員會

計畫名稱
111 貴機構(藥學系(所)謝尚逸副教授申請延攬賴傳穎君參與「化學合成癌症相關之醣蛋白(3/5)」研究計畫案,申請本會補助,業經核定以「博士級研究人員」資格補助(NSTC 111-2811-M-038-005),補助項目為研究費、年終獎金、離職儲金、保險費等
補助單位
國家科學及技術委員會

計畫名稱
111 第23屆國際四面體學術會議(研究生:藥學系(所)碩士班鄭琳蓁君)
補助單位
國家科學及技術委員會

計畫名稱
110 植物新藥多醣成分及含量分析之研究計畫
補助單位
山酮新藥開發股份有限公司

計畫名稱
110 化學合成癌症相關之醣蛋白(2/5)
補助單位
科技部

計畫名稱
109 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
109 Structural profiling of xyloglucans, heteroxylans, and heteromannans in three ginseng species
補助單位
科技部

計畫名稱
109 化學合成癌症相關之醣蛋白(1/5)
補助單位
科技部