王紹安(Wang, Shao-An) 助理教授

Email
sawang0103@tmu.edu.tw
現   職
呼吸治療學系 助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立成功大學生物資訊與訊息傳遞研究所 博士
2007/09~2013/05
國立成功大學藥理學研究所 碩士
2005/09~2007/06
高雄醫學大學藥學系 學士
2001/09~2005/06

本校學術經歷

任職單位與職稱[起迄時間]
呼吸治療學系助理教授
2019/08/01~

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
國立成功大學博士後研究員
2014/08~2019/07
人人藥局藥師
2014/06~2014/07
National Institute of Health, USASpecial Volunteer
2011/10~2012/10

專長與研究領域

學門領域
學術專長
抗藥性
抗藥性
分子及細胞生物學
分子及細胞生物學
癌症分子醫學
癌症分子醫學
轉譯醫學
轉譯醫學
藥理學
藥理學

論文著作

清冊下載


1. 2024 Sharma S,Wang SA,Yang WB,Lin HY,Lai MJ,Chen HC, Kao TY, Hsu FL, Nepali K, Hsu TI, Liou JP. First-in-class dual EZH2-HSP90 inhibitor eliciting striking anti-glioblastoma activity in vitro and in vivo . Journal of Medicinal Chemistry .2024

2. 2024 Young MJ,Wang SA,Chen YC,Liu CY,Hsu KC,Tang SW, Tseng YL, Wang YC, Lin SM, Hung JJ. USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy . Cell Death and Differentiation .2024

3. 2024 Cheng WH,Chang PL,Wu YC,Wang SA,Chen CL,Hsu FL, Neoh MM, Lin LY, Yuliani FS, Lin CH, Chen BC. Neutralization of CX3CL1 Attenuates TGF‑β‑Induced Fibroblast Diferentiation Through NF‑κB Activation and Mitochondrial Dysfunction in Airway Fibrosis . Lung .2024

4. 2023 Wang SA,Wu YC,Yang FM,Hsu FL,Zhang K,Hung JJ. NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells . Molecular Oncology .2023

5. 2022 Young MJ,Chen YC,Wang SA,Chang HP,Yang WB,Lee CC, Liu CY, Tseng YL, Wang YC, Sun HS, Chang WC, Hung JJ. Estradiol‑mediated inhibition of Sp1 decreases miR‑3194‑5p expression to enhance CD44 expression during lung cancer progression . Journal of Biomedical Science .2022

6. 2022 Feng YH,Lim SW,Lin HY,Wang SA,Hsu SP,Kao TJ, Ko CY, Hsu TI. Allopregnanolone suppresses glioblastoma survival through decreasing DPYSL3 and S100A11 expression . The Journal of Steroid Biochemistry and Molecular Biology .2022

7. 2022 Zhang K,Yao E,Wang SA,Chuang E,Wong J,Minichiello L, Schroeder A, Eckalbar E, Wolters PJ, Chuang PT. A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange . Developmental Cell .2022

8. 2022 Ming-Zhen Chen,Shao-An Wang,Shih-Chang Hsu,Kleiton Augusto Santos Silva,Feng-Ming Yang. Home Dust Mites Promote MUC5AC Hyper-Expression by Modulating the sNASP/TRAF6 Axis in the Airway Epithelium . International Journal of Molecular Sciences .2022 ;(16):9405

9. 2021 Wang SA,Yang MJ,Wang YC,Chen SH,Liu CY,Lo YA,Jen HH,Hsu KC,Hung JJ. USP24 Promotes Drug Resistance during Cancer Therapy . Cell death and differentiation .2021

10. 2020 Wang SA,Yang MJ,Jeng WY,Liu CY,Hung JJ. USP24 Stabilizes Bromodomain Containing Proteins to Promote Lung Cancer Malignancy . Scientific Reports .2020 ;(10):20870

11. 2018 Wang Yi Chang,Wu Yu Syuan,Hung Chia Yang,Wang Shao An,Young Ming Jer,Hsu Tsung I.,Hung Jan Jong. USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy . Nature Communications .2018 ;(9):3996-4013

12. 2017 Wang S. A.,Wang Y. C.,Chuang Y. P.,Huang Y. H.,Su W. C.,Chang W. C.,Hung J. J.. EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis . Oncogene .2017 ;(36):2930-2945

13. 2016 Wang Y. C.,Wang S. A.,Chen P. H.,Hsu T. I.,Yang W. B.,Chuang Y. P.,Su W. C.,Liaw H. J.,Chang W. C.,Hung J. J.. Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy . Oncogene .2016 ;(35):3669-3680

14. 2014 Hung Chia Yang,Yang Wen Bin,Wang Shao An,Hsu Tsung I.,Chang Wen Chang,Hung Jan Jong. Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis . Biochimica et Biophysica Acta - Molecular Cell Research .2014 ;(1843):2843-2854

15. 2014 Wang Shao An,Hung Chia Yang,Chuang Jian Ying,Chang Wen Chang,Hsu Tsung I.,Hung Jan Jong. Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression . Biochimica et Biophysica Acta - Molecular Cell Research .2014 ;(1843):1135-1149

16. 2012 Chuang J. Y.,Wang S. A.,Yang W. B.,Yang H. C.,Hung C. Y.,Su T. P.,Chang W. C.,Hung J. J.. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells . Oncogene .2012 ;(31):4946-4959

17. 2011 Wang Shao An,Li Hao Yi,Hsu Tsung I.,Chen Shu Hui,Wu Chin Jen,Chang Wen Chang,Hung Jan Jong. Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis . Journal of Biological Chemistry .2011 ;(286):43816-43829

18. 2010 Liu Yi Wen,Wang Shao An,Hsu Tsung Yi,Chen Tsu An,Chang Wen Chang,Hung Jan Jong. Inhibition of LPS-induced C/EBPδ by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells . Journal of Cellular Biochemistry .2010 ;(110):1430-1438

19. 2009 Wang Shao An,Chuang Jian Ying,Yeh Shiu Hwa,Wang Yi Ting,Liu Yi Wen,Chang Wen Chang,Hung Jan Jong. Heat Shock Protein 90 Is Important for Sp1 Stability during Mitosis . Journal of Molecular Biology .2009 ;(387):1106-1119

研究計畫

計畫名稱
113 去泛素化蛋白二十四在肺纖維化扮演之角色及其機制之探討
補助單位
國家科學及技術委員會

計畫名稱
112 To investigate the role of USP24 on mitochondrial function in drug- resistant lung cancer
補助單位
國家科學及技術委員會

計畫名稱
112 探討USP24抑制劑的鐵依賴性死亡機制並作為癌症抗藥性與纖維化的潛力治療策略
補助單位
國家科學及技術委員會

計畫名稱
111 探討USP24抑制劑的鐵依賴性死亡機制並作為肝纖維化的潛力治療策略
補助單位
國家科學及技術委員會

計畫名稱
111 探討USP24在肺癌與慢性阻塞性肺病之間扮演的角色
補助單位
國家科學及技術委員會

計畫名稱
110 新穎性USP24抑制劑於膠質母細胞瘤抗藥性之機轉探討
補助單位
科技部

計畫名稱
109 利用動物模式在人類鱗狀細胞肺癌中找出新的驅動突變基因(2/2)
補助單位
科技部

計畫名稱
108 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
108 利用動物模式在人類鱗狀細胞肺癌中找出新的驅動突變基因(1/2)
補助單位
科技部