| 1. |
2023
Chang CH,Lin BJ,Chen CH,Nguyen NL,Hsieh TH,Su JH, Chen MC.
Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
. Marine Drugs
.2023
;(21):73-89
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| 2. |
2023
Hsu HL,Lin BJ,Lin YC,Tu CC,Nguyen NL,Wang CC, Chen MC, Chen CH.
Cucurbitacin E Exerts Anti-Proliferative Activity via Promoting p62-Dependent Apoptosis in Human Non-Small-Cell Lung Cancer A549 Cells
. Curr Issues Mol Biol . 2023 Oct 7;45(10):8138-8151.
.2023
;(45):8138-8151
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| 3. |
2023
Jayakumar T,Sheu JR,Yuan KC,Yen TL,Hsia CW,Huang WC, Tseng LN, Chen CH, Hsia CH.
Anti-inflammatory Mechanism of Morin Hydrate by Suppressing the NF-κB/MAPKs Mediated Cell Migration and Modulating Src/FAK and β-Catenin.
. Natural Product Commun.
.2023
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| 4. |
2021
Hsieh TH,Liang ML,Zheng JH,Lin YC,Yang YC,Vo TH, Liou JP, Yen Y, Chen CH.
Combining an Autophagy Inhibitor, MPT0L145, with Abemaciclib Is a New Therapeutic Strategy in GBM Treatment
. Cancers
.2021
;(13):6117-6135
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| 5. |
2020
Ojha R,Nepali K,Chen CH,Chuang KH,Wu TY,Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP.
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo
. European Journal of Medicinal Chemistry
.2020
;(190):112086-112103
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| 6. |
2020
Wu WC,Liu YM,Lin MH,Liao YH,Lai MJ,Chuang HY, Hung TY, Chen CH, Liou JP.
Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response.
. European Journal of Medicinal Chemistry
.2020
;(192):112158-112174
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| 7. |
2020
Lin YC,Chen MC,Hsieh TH,Liou JP,Chen CH.
CK1δ as a potential therapeutic target to treat bladder cancer.
. Aging
.2020
;(12):5764-5780
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| 8. |
2020
Liang ML,Chen CH,Liu YR,Huang MH,Lin YC,Wong TT, Lin SE, Chu SS, Ding YH, Hsieh TH.
Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas
. Cancers
.2020
;(12):3597-3614
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| 9. |
2019
Liu YM,Chen CH,Yeh TK,Liou JP.
Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents
. Future Medicinal Chemistry
.2019
;(11):959-974
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| 10. |
2019
Chen CH,Hsieh TH,Lin YC,Liu YR,Liou JP,Yen Y.
Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells.
. Cancers
.2019
;(11):1345-1358
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| 11. |
2019
Mehndiratta S,Lin MH,Wu YW,Chen CH,Chuang KH,Wu TY, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP..
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression.
. European Journal of Medicinal Chemistry
.2019
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| 12. |
2019
Chen MC,Lin YC,Liao YH,Liou JP,Chen CH.
MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells.
. Cancers
.2019
;(11):1617-1632
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| 13. |
2018
Chen CH,Changou C,Hsieh TH,Lee YC,Chu CY,Hsu KC, Wang HC, Lin YC, Lo YN, Liu YR, Liou JP, Yen Y.
Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer
. Clinical Cancer Research
.2018
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| 14. |
2017
Ho MR,Tsai TT,Chen CL,Jhan MK,Tsai CC,Lee YC, Chen CH, Lin CF.
Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways
. Scientific Reports
.2017
;(7)
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| 15. |
2016
Huang HL,Chao MW,Li YC,Chang LH,Chen CH,Chen MC, Cheng CC, Liou JP, Teng CM, Pan SL.
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer.
. Scientific Reports
.2016
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| 16. |
2016
Yang SH,Lin HY,Changou CA,Chen CH,Liu YR,Wang J, Jiang X, Luh F, Yen Y.
Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma
. Oncotarget
.2016
;(7):362-373
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| 17. |
2016
Chen CH,Liu YM,Pan SL,Liu YR,Liou JP,Yen Y.
Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo
. Oncotarget
.2016
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| 18. |
2015
Chen MC,Zhou B,Zhang K,Yuan YC,Un F,Hu S, Chou CM, Chen CH, Wu J, Wang Y, Liu X, Smith DL, Li H, Liu Z, Warden CD, Su L, et al.
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro
. Mol Pharmacol
.2015
;(87):996-1005
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| 19. |
2015
Liu YM,Lee HY,Chen CH,Lee CH,Wang LT,Pan SL, Lai MJ, Yeh TK, Liou JP.
1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells
. Eur J Med Chem
.2015
;(89):320-330
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| 20. |
2015
Chen CH,Lee CH,Liou JP,Teng CM,Pan SL..
Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acrylamide in human colorectal cancer cells in vitro and in vivo
. Oncotarget
.2015
;(6):35991-36002
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| 21. |
2015
Huang HL,Peng CY,Lai MJ,Chen CH,Lee HY,Wang JC, Liou JP, Pan SL, Teng CM..
Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo
. Oncotarget
.2015
;(6):4976-4991
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| 22. |
2014
Chen CH,Chen MC,Wang JC,Tsai AC,Chen CS,Liou JP, Pan SL, Teng CM.
Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo.
. Clin Cancer Res
.2014
;(20):1274-1287
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| 23. |
2013
Chen MC,Chen CH,Liu YN,Wang HP,Pan SL,Teng CM..
TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells
. Cancer Lett
.2013
;(336):370-378
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| 24. |
2013
Chen MC,Chen CH,Wang JC,Tsai AC,Liou JP,Pan SL, Teng CM..
The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cell
. Cell Death Dis
.2013
;(4):e810
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| 25. |
2012
Chen CH,Liao CH,Chang YL,Guh JH,Pan SL,Teng CM.
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines
. Cancer Lett
.2012
;(315):1-11
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| 26. |
2012
Chao MW,Chen CH,Chang YL,Teng CM,Pan SL.
α-Tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathways
. PLoS One
.2012
;(7):e44093
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| 27. |
2011
Chang LH,Chen CH,Huang DY,Pai HC,Pan SL,Teng CM.
Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells
. J Cell Physiol
.2011
;(226):1060-1068
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| 28. |
2011
Huang PH,Chen CH,Chou CC,Sargeant AM,Kulp SK,Teng CM, Byrd JC, Chen CS.
Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases
. Mol Pharmacol
.2011
;(79):197-206
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| 29. |
2011
Chen MC,Chen CH,Chuang HC,Kulp SK,Teng CM,Chen CS.
Novel Mechanism by Which Histone Deacetylase Inhibitors Facilitate Topoisomerase IIa Degradation in Hepatocellular Carcinoma Cells
. Hepatology
.2011
;(53):148-159
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| 30. |
2011
Chen CH,Huang PH,Chu PC,Chen MC,Chou CC,Wang D, Kulp SK, Teng CM, Wang Q, Chen CS.
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression
. J Biol Chem
.2011
;(286):9968-9976
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