張語曲(Chang Yu-Chu) 副教授

Email
yuchuc@tmu.edu.tw
現   職
細胞治療與再生醫學國際博士學位 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
杜克大學生化系 博士
2003/08~2009/05
臺灣大學物理學系 學士
1997/08~2001/06

本校學術經歷

任職單位與職稱[起迄時間]
細胞治療與再生醫學國際博士學位副教授
2024/08/01~
(舊)細胞治療與再生醫學國際博士學位學程籌備處助理教授
2020/08/01~2024/07/31
生物化學暨細胞分子生物學科助理教授
2017/08/01~2020/07/31
癌症生物學與藥物研發博士學位學程專案助理教授
2016/03/21~2017/07/31
癌症生物學與藥物研發博士學位學程專案助理研究員
2015/08/31~2016/03/20

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
生物化學暨細胞分子生物學科助理教授
2020/08/01 ~
(舊)細胞治療與再生醫學國際博士學位學程籌備處助理教授
2018/08/01 ~ 2020/07/31

其它經歷

任職單位與職稱[起迄時間]
University of California, Los AngelesStaff Research Associate
2015/03/15~2015/08/31
University of California, Los Angeles博士後研究員
2010/03/15~2015/03/14
Duke University博士後研究員
2009/06~2010/02/28

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2024 Chang YC,Cao Z,Chen WT,Huang WC. Effects of stand-alone polar residue on membrane protein stability and structure . BBA-Biomembranes .2024

2. 2024 Kuo CY,Tay RJ,Lin HC,Juan SC,Vidal-Diez de Ulzurrun G,Chang YC, Hoki J, Schroeder FC, Hsueh YP. The nematode-trapping fungus Arthrobotrysoligospora detects prey pheromones viaG protein-coupled receptors . Nature Microbiology .2024

3. 2024 Ching-Yu Lee,Yu-Chu Chang,Kai-Chiang Yang,Yung-fang Lin,Alexander T.H. Wu,Ching-Li Tseng . Development and functional evaluation of a hyaluronic acid coated nano-formulation with kaempferol as a novel intra-articular agent for Knee Osteoarthritis treatment . Biomedicine & Pharmacotherapy .2024 ;(175)

4. 2024 Wen-Jing Hsu,Ming-Chen Chiang,Yi-Chun Chao,Yu-Chu Chang,Ming-Chien Hsu,Chu-Hung Chung, I-Lin Tsai, Cheng-Ying Chu, Han-Chung Wu, Ching-Chieh Yang, Chi-Ching Lee, Cheng-Wei Lin. Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial Homeostasis to Promote Breast Cancer Metastasis . Cancer Research .2024

5. 2023 Lee CH,Lee YY,Chang YC,Pon WL,Lee SP,Wali N, Nakazawa T, Honda Y, Shie JJ, Hsueh YP. A carnivorous mushroomparalyzesand kills nematodesvia a volatile ketone . Science Advances .2023 ;(9)

6. 2023 Huang WC,Chen WT,Chen YC,Fang SB,Huang TW,Chang PR, Chang YC. Salmonella YqiC exerts its function through an oligomeric state . Protein Science .2023

7. 2023 Lee YC,Chang YC,Lee IH,Ho KH,Fang SB,Lauderdale TL, Chen TW, Chen KC, Huang CH, Huang TW. Persistence and dynamic structures of diverse cephalosporinase genes in nontyphoidal Salmonella in cross-sectional surveillance in Taiwan . International Journal of Antimicrobial Agents .2023 ;(62)

8. 2023 Lee KY,Yang CC,Shueng PW,Wu SM,Chen CH,Chao YC, Chang YC, Han CL, Chuang HM, Lee CC, Lin CW. Downregulation of TAZ elicits a mitochondrial redox imbalance and ferroptosis in lung epithelial cells exposed to diesel exhaust particles . Ecotoxicology and Environmental Safety .2023

9. 2023 Hung-Che Lin,Guillermo Vidal-Diez de Ulzurrun,Sheng-An Chen, Ching-Ting Yang,Rebecca J Tay, Tomoyo Iizuka, Tsung-Yu Huang, Chih-Yen Kuo, A Pedro Gonçalves, Siou-Ying Lin, Yu-Chu Chang, Jason E Stajich, Erich M Schwarz, Yen-Ping Hsueh. Key processes required for the different stages of fungal carnivory by a nematode-trapping fungus . PLoS Biology .2023

10. 2022 Fan HH,Fang SB,Chang YC,Huang ST,Huang CH,Chang PR, Chang WC, Yang LTL, Ling PC, Cheng HY. Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium . Journal of Biomedical Science .2022 ;(29):1-23

11. 2021 Fang SB,Lauderdale TY,Huang CH,Chang PR,Wang YH,Shigemura K, Lin YH, Chang WC, Wang KC, Huang TW, Chang YC . Genotypic Diversity of Ciprofloxacin Nonsusceptibility and Its Relationship with Minimum Inhibitory Concentrations in Nontyphoidal Salmonella Clinical Isolates in Taiwan . Antibiotics (Basel) .2021

12. 2021 Hsu WJ,Chen CH,Chang YC,Cheng CH, TsaI YH, Lin CW. PRMT1 Confers Resistance to Olaparib via Modulating MYC Signaling in Triple-Negative Breast Cancer . Journal of Personalized Medicine .2021

13. 2014 Yu-Chu Chang,James U. Bowie. Measuring MembraneProtein Stability under Native Conditions . Proc.Natl.Acad.Sci .2014 ;(111):219-224

14. 2013 Kyle G. Daniels,Nam K. Tonthat,David R. McClure,Yu-Chu Chang,Xin Liu,Maria A. Schumacher, Carol A. Fierke, Scott C. Schmidler, and Terrence G. Oas. Ligand Concentration Regulates the Pathways of Coupled Protein Folding and Binding . J. Am. Chem. Soc. .2013 ;(136):822-825

15. 2010 Yu-Chu Chang,William R. Franch, Terrence G. Oas. Probing the Folding Intermediate of Bacillus subtilis RNase P Protein by Nuclear Magnetic Resonance . Biochemistry .2010 ;(49):9428-9437

16. 2010 Yu-Chu Chang,Terrence G. Oas. Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand . Biochemistry .2010 ;(49):5086-5096

17. 2009 Hammes GG,Chang YC,Oas TG. Conformational selection or induced fit: a flux description of reaction mechanism . Proceedings of the National Academy of Sciences of the United States of America .2009 ;(106):13737-13741


1. 2013 Hong H,Chang YC,Bowie JU. Measuring transmembrane helix interaction strengths in lipid bilayers using steric trapping . Methods Mol. Biol. .2013

研究計畫

計畫名稱
111 探討沙門氏桿菌蛋白質YqiC與電子傳遞鏈複合體II之交互作用
補助單位
國家科學及技術委員會

計畫名稱
110 建立探討膜蛋白折疊的研究平台(3/3)
補助單位
國家科學及技術委員會

計畫名稱
109 建立探討膜蛋白折疊的研究平台(2/3)
補助單位
科技部

計畫名稱
108 建立探討膜蛋白折疊的研究平台(1/3)
補助單位
科技部

計畫名稱
107 利用蛋白質交互作用探討沙門氏菌 YqiC蛋白質的功能
補助單位
科技部

計畫名稱
107 膜蛋白熱力學穩定性及折疊動力學之探討(2/2)
補助單位
科技部

計畫名稱
106 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
106 膜蛋白熱力學穩定性及折疊動力學之探討(1/2)
補助單位
科技部

計畫名稱
105 張語曲助理教授擬於106年6月赴美國波士頓參加Membrane Protein Folding
補助單位