李元綺(Lee, Gladys Yuan-Chii) 教授

Email
ycgl@tmu.edu.tw
現   職
醫學資訊研究所 教授

學經歷

學 歷

畢業學校與學位[修業時間]
英國劍橋大學生化研究所 博士
1994/09~2000/02
東海大學生物研究所 碩士
1988/06~1991/06
東海大學外文系 學士
1983/10~1987/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學資訊研究所教授
2024/02/01~
醫學資訊研究所副教授
2011/02/01~2024/01/31
醫學資訊研究所(舊)副教授
2009/02/01~2011/01/31
醫學資訊研究所(舊)助理教授
2003/08/01~2009/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學生物科技博士學位學程籌備處
2015/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
國家衛生研究院博士後研究
2000/03/01~2003/07/31
中央研究院研究助理
1992/07/01~1993/08/31

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2023 Lim HGM,Fann YC,Lee YCG. COWID: an efficient cloud-based genomics workflow for scalable identification of SARS-COV-2 . Briefings in Bioinformatics .2023 ;(24):bbad280-12

2. 2023 Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells . International Journal of Molecular Sciences .2023 ;(24):9738

3. 2022 Humoral Immunogenicity and Reactogenicity of the Standard ChAdOx1 nCoV-19 Vaccination in Taiwan . Vaccines .2022 ;(10):312-326

4. 2022 Exerting the Appropriate Application of Methylprednisolone in Acute Spinal Cord Injury Based on Time Course Transcriptomics Analysis . International Journal of Molecular Sciences .2022 ;(22):13024

5. 2022 Robust Mutation Profiling of SARS-CoV-2 Variants from Multiple Raw Illumina Sequencing Data with Cloud Workflow . Genes .2022

6. 2022 L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells . Scientific Reports .2022

7. 2021 Perfluorooctane sulfonate induces autophagy-associated apoptosis through oxidative stress and the activation of extracellular signal–regulated kinases in renal tubular cells . PLOS ONE .2021 ;(16):e0245442-0245457

8. 2021 Hendrick Gao-Min Lim,Shih-Hsin Hsiao,Yuan-Chii Gladys Lee. Orchestrating an Optimized Next-Generation Sequencing-Based Cloud Workflow for Robust Viral Identification during Pandemics . Biology .2021 ;(10):1023-1037

9. 2020 Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism . Biochim Biophys Acta Gene Regul Mech .2020 ;(1863):194601-194612

10. 2019 Lee Yuan Chii G. ,Sue Yuh Mou ,Lee Ching Kuo ,Huang Huei Mei ,He Jhin Jyun ,Wang Yu Shiou, Juan Shu Hui. Synergistic effects of cAMP–dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes . Phytomedicine .2019 ;(55):255-263

11. 2019 Simvastatin reduces the carcinogenic efect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation . Scientific Reports .2019 ;(9):4606-4618

12. 2019 Berberine promotes beige adipogenic signatures of 3T3-L1 cells by regulating post-transcriptional events . Cells .2019 ;(8):632-646

13. 2018 Lin JC,Lee YC,Tan TH,Liang YC,Chuang HC,Fann YC, Johnson KR, Lin YJ. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell . Biochimica et Biophysica Acta (BBA)-Molecular Cell Research .2018 ;(1865):259-272

14. 2017 Lin JC,Lee YC,Liang YC,Fann YC,Johnson KR,Lin YJ. The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells . Scientific Report .2017 ;(7):44202-44212

15. 2017 Chang CC,Hsu YH,Chou HC,Lee YCG,Juan SH. 3-Methylcholanthrene/Aryl-Hydrocarbon Receptor-Mediated Hypertension Through eNOS Inactivation . Journal of Cellular Physiology .2017 ;(232):1020-1029

16. 2014 Sun LM,Wang KH,Lee YCG. Keloid incidence in Asian People and its comorbidity with other fibrosis-related diseases: a nationwide population-based study . Archives of Dermatological Researcfh .2014 ;(306):803-808

17. 2014 Wei TYW,Hsia JY,Chiu SC,Su LJ,Juan CC,Lee YCG, Chen JMM, Chou HY, Huang JY, Huang HM, Yu CTR. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis . Cellular Signalling .2014 ;(26):2940-2950

18. 2013 Wu D,Lee YCG,Liu HC,Yuan RY,Chiou HY,Hung CH, Hu CJ. Identification of TLR downstream pathways in stroke patients . Clinical Biochemistry .2013 ;(46):1058-1064

19. 2012 Wei TY,Juan CC,Hisa JY,Su LJ,Lee YC,Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade . Cancer Science .2012 ;(103):1640-1650

20. 2011 Yeh CY,Shin SM,Yeh HH,Wu TJ,Shin JW,Chang TY, Raghavaraju G, LEE CT, Chiang JH, Tseng VS, LEE YC, Shen CH, Chow NH, Liu HS. Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer . BMC Cancer .2011 ;(11):139-150

21. 2011 Yu CT,Hsia JY,Hseih YC,Su LJ,Lee TC,Ku CF, Chen KS, Chen JM, Wei TY, Lee YC, Huang CY, Wu YC, Yang CY, Hsu SL. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A . J Thorac Oncol .2011 ;(6):988-997

22. 2010 Lee CC,Jan HJ,Lai JH,Ma HI,Hueng DY,Lee YCG, Cheng YY, Liu LW, Wei HW, Lee HM. Nodal Promotes growth and invasion in human gliiomas . Oncogene .2010 ;(29):3110-3123

23. 2010 Wu MM,Hsieh YC,Lien LM,Chen WH,Bai CH,Chiu HC, Chen HH, CHung WT, Lee YC, Hsu CY, Lin HW, Chiou HY. Associateion of Estrogen Receptor Alpha Genotypes/Haplotypes with Carotid Intima-Media Thickness in Taiwan Women . Angiology .2010 ;(61):275-282

24. 2009 Chen CH,Lai JM,Chou TY,Chen CY,Su LJ,Lee YC, Cheng TS, Hong YR, Chou CK, Whang-Peng J, Wu YC, Huang CY. VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway . PLoS One .2009 ;(4):e5052-e5063

25. 2008 Torng PL,Lee YCG,Huang CY,Ye JH,Lin YS,Chu YW, Huang SC, Cohen P, Wu CW, Lin CT. Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma . Oncogene .2008 ;(27):2137-2147

26. 2007 Lee YCG,Hwang YC,Chen KC,Huang DY,Huang TW,Kao CY, Wu HC, Lin CT, Huang CYF. Effect of Epstein-Barr Virus infection on global gene expression in nasopharyngeal carcinoma . Functional and Integrative Genomics .2007 ;(7):79-93

27. 2007 Chen KY,Lee YCG,Lai JM,Chang YL,Lee YC,Yu CJ, Huang CYF, Yang PC. Identification of Trophinin as an Enhancer for Cell Invasion and a Prognostic Factor for Early Stage Lung Cancer . European Journal of Cancer .2007 ;(43):782-790

28. 2007 Chen CH,Lu PJ,Chen YC,Fu SL,Wu KJ,Tsou AP, Lee YCG, Lin TCE, Hsu SL, Lin WJ, Huang C. FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway . Oncogene .2007 ;(26):4272-4283

29. 2006 Lee CM,Chen SY,Lee YCG,Huang CYF,Chen YMA. Benzo[a]pyrene and glycine N-methyltransferse Interactions: Gene expression profiles of the liver detoxification pa . Toxicology and Applied Pharmacology .2006 ;(214):126-135

30. 2006 Yen YT,Chen B,Chiu HW,Lee YCG,Li YC,Hsu CY. Developing a NLP and IR-Based Algorithm for Analyzing Gene-disease Relationship . Methods of Information in Medicine .2006 ;(45):321-329

31. 2005 Lu TJ,Huang CYF,Yuan CJ,Lee YC,Leu TH,Chang WC, Lu TL, Jeng WY, Lai MD. Zinc ion acts as a cofactor for serine/threonin kinase MST3 and has a distinct role in autophosphorylation of MST3 . Journal of Inorganic Biochemistry .2005 ;(99):1306-1313

32. 2005 Yu CTR,Hsu JM,Lee YCG,Tsou AP,Chou CK,Huang CTF. Phosphorylatiuon and Stabilization of HURP by Aurora-A: Implication of HURP as a Transforming Target of Aurora-A . Molecular and Cellular Biology .2005 ;(25):5789-5800

33. 2004 Huang TW,Tien AC,Huang WS,Lee YCG,Peng CL,Tseng HH, Kao CY, Huang CYF. POINT: a database for thprediction of proteine -protein interactions based on the orthologous interactome . Bioinformatics .2004 ;(20):3273-3276

34. 2004 Tien AC,Lin MH,Su LJ,Hong YR,Cheng TS,Lee YC, Lin WJ, Still, IH, Huang CY. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model . Molecular and Cellular Proteomics .2004 ;(3):93-104

35. 2004 Hsu JM,Lee YCG,Yu CTR,Huang CYF. Fbx7 functions in the SCF complex regulating Cdk1-Cyclin B-phosphorylated HURP proteolysis by protein-rich region . Journal of Biological Chemistry .2004 ;(279):32592-32602

36. 2003 Jin-Yuan Shih, Yuan-Chii G. Lee, Shuenn-Chen Yang, Tse-Ming Hong, CShih JY, Lee YCG, Yang SC, Hong TM, Huang CYF and Yang PC. Collapsin Response Mediator Protein-1: A Novel Invasion-Suppressor Gene . Clinical and Experimental Metastasis .2003 ;(20):69-74

37. 2003 Tsou AP, Yang CW, Huang CYF, Yu CTR, Lee YCG, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH and Chou CK. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma . Oncogene .2003 ;(22):298-307

38. 2001 Ellenrieder C, Bartosch B, Lee GYC, Murphy M, Sweeney C, Hergersberg M, Carrington M, Jaussi R and Hunt T. The long form of CDK2 arises via alternative splicing and forms an active protein kinase with cyclins A and E . DNA and Cell Biology .2001 ;(20):412-423


1. 2022 Lim HGM,Fann YC,Lee YCG. Proteotranscriptomics Analysis Reveals Signature Pathways Associated with Colorectal Cancer Progression: a Pilot Study . 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE) .2022

2. 2021 Lim HGM,Lee YCG. Transcriptomics and Proteomics Analysis to Identify Signature Pathways in Colorectal Cancer Progression . 14th Great Lakes Bioinformatics (GLBIO). Organization: Great Lakes Bioinformatics Consortium of International Society for Computational Biology. Virtual conference .2021

3. 2020 Lim HGM,Lee YCG. Using Gene-level to Generalize Transcript-level Classification Performance on Multiple Colorectal Cancer Microarray Studies . 10th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB), Organization: Chemical, Biological & Environmental Engineering Society (CBEES), at Kyoto, Japan .2020

4. 2020 Lim HGM,Lee YCG. Empowering Cloud Technology for SARS-CoV2 Identification. 28th Conference on Intelligent Systems for Molecular Biology . (ISMB 2020), Organization: International Society for Computational Biology (ISCB). Virtual conference .2020

5. 2019 Lim HGM,Lee YCG. A Cross-Platform Comparison of Affymetrix, Agilent, and Illumina Microarray Reveals Functional Genomics in Colorectal Cancer Progression . 41st International Engineering in Medicine and Biology Conference (EMBC), Organization: IEEE EMBS, at CityCube Berlin, Germany .2019

6. 2019 Lim HGM,Lee YCG. Comparative Study between Transcript-level and Gene-level Classification on Multiple Affymetrix Platforms of Colorectal Cancer Microarray Studies . 18th International Conference on Bioinformatics (InCoB), Organization: Asia Pacific BioInformatics Network (APBioNET) , at Universitas YARSI, Jakarta, Indonesia .2019

研究計畫

計畫名稱
113 整合型圖展示學習於精準腫瘤學之應用:揭示肺腺癌中EGFR Exon19Del和L858R突變的不同生物路徑
補助單位
國家科學及技術委員會

計畫名稱
111 雲為基礎的 “圖展示學習” 技術以物路徑及蛋-轉錄組學來研究癌症系統物學
補助單位
國家科學及技術委員會

計畫名稱
109 植基於圖技術的雲癌症精準醫學之機器學習模組
補助單位
科技部

計畫名稱
109 醫學資訊研究所博士班研究生Hendrick君擬於110年5月10日至110年5月13日參加14th Great Lakes Bioinformatics conference 2021
補助單位
科技部

計畫名稱
107 醫學資訊研究所博士生Hendrick君擬於108年7月23日至7月27日赴德國柏林參加41st International Engineering in Medicine and Biology Conference,依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案
補助單位

計畫名稱
105 以RNA-seq分析來探討HIV提高non-AIDS-defining malignancies罹患率之分子機制
補助單位
科技部

計畫名稱
105 多元生物資訊分析台灣本土癌症RNA次世代定序數據研究人類內源性反轉錄病毒的致癌因子(2/2)
補助單位
科技部

計畫名稱
105 多元生物資訊分析台灣本土癌症RNA次世代定序數據研究人類內源性反轉錄病毒的致癌因子(2/2)
補助單位

計畫名稱
104 多元生物資訊分析台灣本土癌症RNA次世代定序數據研究人類內源性反轉錄病毒的致癌因子(1/2)
補助單位
科技部

計畫名稱
104 多元生物資訊分析台灣本土癌症RNA次世代定序數據研究人類內源性反轉錄病毒的致癌因子(1/2)
補助單位
科技部

計畫名稱
104 醫學資訊研究所李元綺副教授擬邀請EMBL-European Bioinformatics Institute (EMBL-EBI) Charles E.Cook研究員,於105年05月09日至105年05月14日來台訪問,依補助邀請國際科技人士短期訪問作業要點申請補助經費乙案
補助單位

計畫名稱
103 次世代RNA定序數據分析人類內源性逆轉錄病毒與癌症的關係
補助單位
科技部

計畫名稱
103 以MICRORNA與基因架構出階層式調控網路來揭露疾病發生過程:以子宮肌瘤和蟹足腫疾病為例
補助單位
科技部

計畫名稱
100 革新的疾病相關路徑鑑定法:從全基因調控路徑的建立、路徑尋找,到路徑分析與驗證
補助單位
行政院國家科學委員會

計畫名稱
99 從系統生物學的全方位研究到「抑制癌細胞轉移」之標靶藥物的製成
補助單位
行政院衛生署

計畫名稱
97 以生物路徑表現量之分析方法研發阻斷癌轉移的標靶藥物
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
95 以生物資訊為主導之醫學研究協尋癌症轉移基因
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
93 建立以微陣列及知識為基礎的人類疾病及基因之線上資料庫
補助單位
行政院國家科學委員會

計畫名稱
92 蛋白質體間交互作用之組織網路之探索
補助單位
臺北醫學大學專題