| 1. |
2024
Rachmawati Sumitraa M,Chen LC ,Tsai WC,Ansarf M,Lawal B, ,Mokgautsia N, Guh JH, Wu ATH, Huang HS.
Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3-c]quinolin-12(12H)-ones as potential breast cancer drugs
. Arabian Journal of Chemistry
.2024
;(17)
|
|
| 2. |
2024
Srivastava P,Yadav KV,Chang TH,Su CY ,Lawal B,Wu ATH, Huang HS.
In-Silico Analysis of TMEM2 as a Pancreatic Adenocarcinoma and Cancer-Associated Fibroblast Biomarker, and functional characterization of NSC777201, for targeted drug development
. American Journal of Cancer Research
.2024
;(14):3010-3035
|
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| 3. |
2024
Lukman HY ,Kuo YC ,Owolabi MS, ,Lawal B,Chen LC,Ajenifujah OT, Fadaka AO, Olawale F, Onikanni AS, Saidu S, Waard MD, Fouad D, Batiha SES, Sabiu S, Wu ATH, Huang HS.
Evaluation of terpenes rich Hura crepitans Extract on Glucose Regulation and Diabetic Complications in STZ-induced Diabetic Rats
. Biomedicine and Pharmacotherary
.2024
;(179):117308
|
|
| 4. |
2023
Hogan IA,Kuo YC,Abubakar AN ,Lawal B,Agboola AR ,Lukman HY, Onikanni AS, Olawale F, Fadaka AO, Ibrahim YO, Babalola SB, Batiha GES, Albogami SM, Alorabi M, Waard MD, Huang HS*.
Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens methanol extract
. Biomedicine and Pharmacotherary
.2023
;(158):114114-114131
|
|
| 5. |
2023
Chen YF,Lawal B,Huang LJ ,Kuo SC ,Rachmawati Sumitra M,Mokgautsi N, Lin HY*, Huang HS*.
In Vitro and In Silico Biological Studies of 4-Phenyl-2-Quinolone (4-PQ) Derivatives as Anticancer Agents
. Molecules
.2023
;(28):555-579
|
|
| 6. |
2023
Mokgautsi N, ,Kuo YC,Huang YJ,Chen CH,Mukhopadhyay D,Wu ATH*, Huang HS*.
Preclinical Evaluation of a Novel Small Molecule LCC-21 to Suppress Colorectal Cancer (CRC) Malignancy by Inhibiting Angiogenic and Metastatic Oncogenic Signatures
. Cells
.2023
;(12):266-292
|
|
| 7. |
2023
Mokgautsi N,Kuo YC,Chen CH,Huang YJ,Wu ATH ,Huang HS.
Multi-omics study of a novel naturally derived small molecule, NSC772864, as a potential inhibitor of proto-oncogenes regu-lating cell cycle progression in colorectal cancer
. Cells
.2023
;(12):340-367
|
|
| 8. |
2023
Huang HS,Chiang IT ,Lawal B,Weng YS,Jeng LB,Kuo YC, Liu YC, Hsu FT.
A Novel Isotope-labeled Small Molecule Probe CC12 for Anti-glioma via Suppressing LYN-mediated Progression and Activating Apoptosis Pathways
. International Journal of Biological Sciences
.2023
;(19):3209-3225
|
|
| 9. |
2023
Lawal B,Tsai SK ,Wu ATH,Huang HS.
In silico study of Novel Niclosamide Derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidates
. Arabian Journal of Chemistry
.2023
;(16):104654-104676
|
|
| 10. |
2023
Lawal B ,Kuo YC ,Wu ATH ,Huang HS.
Therapeutic potential of EGFR/mTOR/Nf-kb targeting small molecule for the treatment of non-small cell lung Cancer
. American Journal of Cancer Research
.2023
;(13):2598-2616
|
|
| 11. |
2023
Abdulrasheed-Adeleke T,Lawal B ,Agwupuye EI,Kuo YC,Eni AM,Ekoh OF, Lukman HY, Onikanni AS, Olawale F, Saidu S, Ibrahim YO, Al Ghamdi MAS, Aggad SS, Alsayegh AA, Aljarba NH, Batiha GES, Wu ATH, Huang HS.
Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic beta-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats
. Biomed Pharmacother
.2023
;(162):114582-114602
|
|
| 12. |
2023
Lawal B ,Kuo YC,Onikanni AS,Chen YF,Abdulrasheed-Adeleke T ,Fadaka AO, Olugbodi JO, Lukman HY, Olawale F, Mahmoud MH, Batiha GES, Wu ATH, Huang HS* .
Computational identification of novel signature of T2DM-induced nephropathy and therapeutic potential of bioactive compounds from Azanza garckeana
. American Journal of Translational Research
.2023
;(15):4504-4520
|
|
| 13. |
2023
Nivrutti Khedkar H,Chen LC ,Kuo YC,Wu ATH ,Huang HS*.
Multi-Omics Identification of Genetic Alterations in Head and Neck Squamous Cell Carcinoma and Therapeutic Efficacy of HNC018 as a Novel Multi-Target Agent for c-MET/STAT3/AKT Signaling Axis
. International Journal of Molecular Sciences
.2023
;(24):10247-10269
|
|
| 14. |
2023
Chen LC,Mokgautsi N, ,Kuo YC,Wu ATH*,Huang HS*.
In Silico Evaluation of HN-N07 Small Molecule as an Inhibitor of Angiogenesis and Lymphangiogenesis Oncogenic Signatures in Non-Small Cell Lung Cancer
. Biomedicines
.2023
;(11):2011-2034
|
|
| 15. |
2023
Chiang YC,Leu WJ ,Chen YC,Ye PC ,Hsiao YC ,Hsu JL, Hsu LC, Huang HS,* Guh JH*.
Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancer
. Prostate
.2023
|
|
| 16. |
2023
Kuo YC ,Cheng CY,Chen LC,Lawal B ,Shih PJ ,Huang HS.
Diagnosis of kidney insufficiency by using the pressure waveforms of wrist-type sphygmomanometers: Toward a convenient point-of-care device
. American Journal of Translational Research
.2023
|
|
| 17. |
2023
Chinyama HA ,Wei L,Mokgautsi N,Lawal B,Wu ATH,Huang HS.
Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent.
. International Journal of Molecular Sciences
.2023
|
|
| 18. |
2022
George T,Chen M,Czosseck A,Chen HP ,Huang HS ,Lundy D.
Liposomal encapsulation of cytotoxic multi-target inhibitor improves efficacy and safety profile in triple negative breast cancer
. Journal of Controlled Release
.2022
;(342):31-43
|
|
| 19. |
2022
Mokgautsi N, ,Kuo YC ,Tang SL, ,Liu FC,Chen SJ,Wu ATH*, Huang HS*.
Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradiore-sistant Cell Cycle-Related Oncogenic Signatures
. Cancers
.2022
;(14):262-284
|
|
| 20. |
2022
Lawal B ,Wu ATH,Huang HS.
Leveraging bulk and single-cell RNA sequencing data of NSCLC tumor microenvironment and therapeutic potential of NLOC-15A, a novel multitarget small molecule
. Frontiers in Immunology
.2022
|
|
| 21. |
2022
Alozieuwa UB,Lawal B ,Sani S,Onikanni AS ,Osuji O,Ibrahim YO, Babalola SB, Mostafa-Hedeab G, Alsayegh AA, Batiha GES, Wu ATH, Huang HS,* Conte-Junior CA.
Luteolin-Rich Extract of Thespesia garckeana F. Hoffm. (Snot Apple) Contains Potential Drug-Like Candidates and Modulates Glycemic and Oxidoinflammatory Aberrations in Experimental Animals
. Oxidative Medicine and Cellular Longevity
.2022
|
|
| 22. |
2022
Lawal B ,Sani S ,Onikanni AS ,Ibrahim YO ,Agboola AR ,Lukman HY, Olawale F, Jigam AA, Batiha GES, Babalola SB, Mostafa-Hedeab G, Gonçalves Lima CM, Wu ATH*, Huang HS*, Conte-Junior CA.
Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents
. Biomedicine & Pharmacotherapy
.2022
;(152):113196
|
|
| 23. |
2022
Lawal B ,Kuo YC ,Khedkar H,Mokgautsi N, ,Sumitra MR,Wu ATH*, Huang HS*.
Deciphering the immuno-pathogenic role of FLT, and evaluation of a novel Dual Inhibitor of Topoisomerases and Mutant-FLT3 for Treating Leukemia
. American J Cancer Research
.2022
;(12):5140-5159
|
|
| 24. |
2022
Lawal B ,Kuo YC,Sumitra MR,Wu ATH*,Huang HS*.
Identification of novel inflammatory and immune response target-signature of Sars-COVID-19 infections: RXn-02 Pharmacokinetics and potential translational therapy
. Computers in Biology and Medicine
.2022
;(148):105814
|
|
| 25. |
2021
Lawal B ,Kuo YC,Wu ATH ,Huang HS.
BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase
. International Journal of Biological Sciences
.2021
;(17):3224-3238
|
|
| 26. |
2021
Huang TH ,Mokgautsi, N,Huang YJ ,Wu THA ,Huang HS.
Comprehensive Omics Analysis of a Novel Small-Molecule In-hibitor of Chemoresistant Oncogenic Signatures in Colorectal Cancer Cell with Antitumor Effects
. Cells
.2021
;(10):1970-1994
|
|
| 27. |
2021
Bashir L,Kuo YC ,Sumitra MR ,Wu ATH,Huang HS.
In vivo pharmacokinetic and anticancer studies of HH-N25, a selective inhibitor of topoisomerase I, and hormonal signaling for treating breast cancer
. Journal of Inflammation Research
.2021
;(14):4901-4913
|
|
| 28. |
2021
Lawal B ,Kuo YC, S,Tang SL ,Liu FC,Wu ATH ,Lin HY, Huang HS*.
Transcriptomic-based identification of the immuno-oncogenic signature of cholangiocarcinoma for HLC-018 multi-target therapy exploration
. Cells
.2021
;(10):2873-2896
|
|
| 29. |
2021
Yang SR,Hung SC,Chu LJ ,Hua KF, ,Wei CW, ,Tsai IL, Kao CC, Sung CC, Wu CY, Chen A, Wu ATH, Liu FC, Huang HS, Ka SM*.
NSC828779 alleviates renal tubulointerstitial lesions involving interleukin-36 signaling in mice
. Cells
.2021
;(10):3060-3078
|
|
| 30. |
2021
Ahmed AAA,Lee YR,Wu THA,Yadav VK,Yu DS,Huang HS.
Structure-based strategies for synthesis and lead optimization of N-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as potential multi-target anticancer agents
. Arab. J. Chem.
.2021
;(14):102884-102907
|
|
| 31. |
2021
Angom RS,Zhu J,Wu TH Alexander,Rachmawati-Sumitra M,Pham V,Dutta S, Wang E, Madamsetty V, Perez Cordero GD, Huang HS, Mukhopadhyay D, Wang Y.
LCC-09, a novel salicylanilide derivative, exerts anti-inflammatory effect in vascular endothelial cells
. Journal of Inflammation Research
.2021
;(14):4551-4565
|
|
| 32. |
2021
Yang SR,Hua KF,Takahata A,Wu CY,Hsieh CY,Chiu HW, Chen CH, Mukhopadhyay D, Suzuk Y,Ka SM, Huang HS, Chen A..
LCC18, a benzamide-linked small molecule, ameliorates IgA nephropathy in mice
. The Journal of Pathology
.2021
;(253):427-441
|
|
| 33. |
2021
Lawal B,Liu YL,Mokgautsi N ,Khedkar H ,Rachmawati-Sumitra M,Wu THA, Huang HS.
Pharmacoinformatics and preclinical studies of NSC765690 and NSC765599, potential STAT3/CDK2/4/6 inhibitors with antitumor activities against NCI60 human tumor cell lines
. Biomedicines
.2021
;(9)
|
|
| 34. |
2021
Lawal B ,Lee CY ,Mokgautsi N,Sumitra RM ,Khedkar H,Wu THA, Huang HS.
mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 are druggable candidates for N-(2,4-difluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide (NSC765598), with consequent anticancer implications
. Frontiers in Oncology
.2021
;(11):656738-656761
|
|
| 35. |
2021
Mokgautsi N ,Wen YT,Lawal B,Khedkar H,Sumitra RM,Wu THA, Huang HS.
An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a potential GSK3β/β-Catenin/STAT3/CD44 suppressor with Anti-Glioblastoma Properties
. International Journal of Molecular Sciences
.2021
;(22):2464-2487
|
|
| 36. |
2021
Lawal B ,Lo WC,Mokgautsi N,Sumitra RM, Khedkar H,Wu THA, Huang HS.
A Preclinical Report of a Cobimetinib-Inspired Novel Anticancer Small-Molecule Scaffold of Isoflavones, NSC777213, for Targeting PI3K/AKT/mTOR/MEK in multiple cancers
. American Journal of Cancer Research
.2021
;(11):2590-2617
|
|
| 37. |
2021
Wu THA,Huang HS,Wen YT, Lawal B ,Mokgautsi N,Huynh TT, Hsiao M, Wei L.
A preclinical investigation of GBM-N019 as a potential inhibitor of glioblastoma multiform via exosoamal mTOR/CDK6/STAT3 signaling
. Cells
.2021
;(10):2391-2411
|
|
| 38. |
2021
Lawal B ,Wang YC,Wu THA,Huang HS.
Pro-oncogenic c-Met/EGFR, biomarker signatures of the tumor microenvironment are clinical and therapy response prognosticators in colorectal cancer, and therapeutic targets of 3-phenyl-2H-benzo[e][1,3]-oxazine-2,4(3H)-dione derivatives
. Frontiers in Pharmacology
.2021
;(12):691234
|
|
| 39. |
2021
Mokgautsi N ,Wang YC ,Lawal B ,Khedkar H,Sumitra RM,Wu ATH, Huang HS .
Network Pharmacological Analysis Through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Multiple Cancer types
. Cancers
.2021
;(13):2523-2547
|
|
| 40. |
2021
Khedkar Nivrutti H,Wang YC,Yadav VK,Srivastava P,Lawal B,Mokgautsi N, Sumitra RM, Wu ATH, Huang HS.
In-silico evaluation of genetic alterations in ovarian carcinoma and therapeutic efficacy of NSC777201, as a novel multi-target agent for TTK, NEK2, and CDK1
. International Journal of Molecular Sciences
.2021
;(22):5895-5915
|
|
| 41. |
2021
Yang SR,Hua KF,Wu CY,Chen A ,Weng JC,Tsai YL, Wan CJ, Lee CC, Chan JF, Hsieh CY, Hsu YJ, Wu CC, Mukhopadhyay D, Huang HS, Liu FC, Ka SM.
Cf-02, a novel benzamide-linked small molecule, blunts NF-κB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice
. The FASEB Journal
.2021
;(35):e21785
|
|
| 42. |
2020
Chiu YS ,Wu JL ,Yeh CT ,Yadav VK ,Huang HS ,Wang LS .
γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling
. Aging-US
.2020
;(12):6630-6643
|
|
| 43. |
2020
Fann LY,Shih JH,Tseng JH,Huang HS,Hsiao SH.
CC12 induces apoptotic cell death and cell cycle arrest in human glioblastoma cell line and mouse xenograft model
. Molecules
.2020
;(25):1793-1808
|
|
| 44. |
2020
Kung CC ,Dai SP ,Chiang H,Huang HS ,Sun WH.
Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression
. Molecular Biology Reports
.2020
;(47):3423–3437-3437
|
|
| 45. |
2020
Su YS,Chen H,Hsieh WS,Chen CH,Jiang H,Huang HS, Chang DM, Huang SL, Sun WH*.
TDAG8 deficiency reduces satellite glial number and proinflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain
. Journal of Neuroinflammation
.2020
;(17):170-186
|
|
| 46. |
2020
Yadav VK ,Huang YJ ,George TA,Wei PL,Sumitra MR,Ho CL, Chang TH, Wu ATH,* Huang HS* .
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation
. Cancers
.2020
;(12):1590-1605
|
|
| 47. |
2020
Lee JC,Wu THA,Chen JH,Huang WY,Lawal B ,Mokgautsi N, Huang HS*, Ho CL.
HNC0014, a multi-targeted small-molecule, inhibits head and neck squamous cell carcinoma by suppressing c-Met/STAT3/CD44/PD-L1 oncoimmune signature and eliciting anti-tumor immune responses
. Cancers
.2020
;(12):3759-3777
|
|
| 48. |
2020
Hsieh CL,Huang HS,Chen KC,Saka T,Chiang CY ,Chung WK, Sung SY.
A novel salicylanilide derivative induces autophagy cell death in castration-resistant prostate cancer via ER stress-activated PERK signaling pathway
. Molecular Cancer Therapeutics
.2020
;(19):101-111
|
|
| 49. |
2019
Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02
. Biochemical and Biophysical Research Communications
.2019
;(517):155-163
|
|
| 50. |
2019
Wen YT,Wu ATH ,Bamodu OA ,Wei L ,Lin CM,Yen Y, Chao TY, Mukhopadhyay Hsiao M,* Huang HS.
A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis
. Cancers
.2019
;(11):10.3390/cancers11101442
|
|
| 51. |
2019
Shen CJ,Lin PL,Lin HC,Cheng YW,Huang HS,Lee H.
RV-59 suppresses cytoplasmic Nrf2-mediated 5-fluorouracil resistance and tumor growth in colorectal cancer
. American Journal of Cancer Research
.2019
;(9):2789-2796
|
|
| 52. |
2019
Madamsetty VS ,Pal K ,Dutta SK ,Wang E,Thompson JR,Banerjee RK, Caulfield TR, Mody K, Yen Y, Mody K, Banerjee RK, Mukhopadhyay D, Huang HS.
Design and evaluation of PEGylated liposomal formulation of a novel multi-kinase inhibitor for enhanced chemosensitivity and inhibition of metastatic pancreatic ductal adenocarcinoma
. Bioconjugate Chemistry
.2019
;(30):2703-2713
|
|
| 53. |
2019
Chen TC,Guh JH,Hsu HW,Chen CL,Lee CC,Wu CL, Lee YR, Lin JJ., Yu DS, Huang HS.
Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents
. Arab. J. Chem.
.2019
;(12):2864-2881
|
|
| 54. |
2019
Chen CL,Chen TC,Lee CC,Shih LC,Lin CY,Hsieh YY, Ahmed Atef AA, Huang HS.
Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents
. Arab. J. Chem.
.2019
;(12):3503-3516
|
|
| 55. |
2019
Chen TC,Yu DS,Chen SJ,Chen CL,Lee CC,Hsieh YY; Chang LC; Guh JH, Lin JJ; Huang HS*.
Design, Synthesis and Biological Evaluation of Tetracyclic Azafluorenone Derivatives with Topoisomerase I Inhibitory Properties as Potential Anticancer Agents
. Arab. J. Chem.
.2019
;(12):43484-4364
|
|
| 56. |
2018
Liu FC,Lu JW,Chien CY,Huang HS,Lee CC,Lien SB, Lin LC, Chen WC, Ho YJ, Shen MC, Ho LJ, Lai JH.
Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin
. Int. J. Mol. Sci.
.2018
;(19):1453-1466
|
|
| 57. |
2018
Wu CL,Chen CL,Huang HS,Yu DS.
A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis related pathway
. Cancer Medicine
.2018
;(7):3945-3954
|
|
| 58. |
2018
Wu, J. L.,Lee, C. H.,Yang, C. T.,Chang, C. M.,Li, G.,Cheng, C. K., Chen, C. H., Huang, H. S.*, Lai, Y. S.*.
Novel technique for repairing posterior medial meniscus root tears using porcine knees and biomechanical study
. PlosOne
.2018
;(13):0192027
|
|
| 59. |
2018
Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system
. Nanomedicine: Nanotechnology, Biology, and Medicine
.2018
;(14):1019-1031
|
|
| 60. |
2018
Fann LY,Chen Y,Chu DC,Weng SJ,Chu HC,Wu TH, Lee JF, Ali AAA, Chen TC, Huang HS*, Ma KH*.
Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways
. Oncotarget
.2018
;(9):11922-11937
|
|
| 61. |
2017
Liu FL,Chen CL,Lee CC,Wu CC,Hsu TH,Tsai CY, Huang HS, Chang DM.
The Simultaneous Inhibitory Effect of Niclosamide on RANKL-Induced Osteoclast Formation and Osteoblast Differentiation
. Int. J. Med. Sci.
.2017
;(14):840-852
|
|
| 62. |
2016
Lee CC,Chen CL,Liu FL,Chiou CY,Chen TC,Wu CC, Sun WH,Chang DM, Huang HS.
Development of 1-amino-4-(phenylamino)anthraquinone-2-sulfonate sodium derivatives as a new class of inhibitors of RANKL-induced osteoclastogenesis
. Arch Pharm
.2016
;(349):342-355
|
|
| 63. |
2016
Ahmed Ali AA,Hsu FT,Hsieh CL,Shiau CY,Chiang CH,Wei ZH, Chen CY*, Huang HS*.
Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI
. Scientific Reports
.2016
;(6):36650
|
|
| 64. |
2016
Wu DW,Chen TC,Huang HS,Lee H.
TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small cell lung cancer cells
. Cell Death Dis
.2016
;(7):e2290
|
|
| 65. |
2016
Lin YH,Chuang SM,Chen CL,Jeyachandran S,Lo SC,Wu PC, Huang HS*, Hou MH*.
Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G‐quadruplex DNA
. Sci Rep
.2016
;(6):31019
|
|
| 66. |
2016
Chang LC,Chen TC,Chen SJ,Chen CL,Lee CC,Wu SH, Yen Y, Huang HS, Lin JJ.
Identification of a new class of WNT1 inhibitor: cancer cells migration, G-quadruplex stabilization and target validation
. Oncotarget
.2016
;(7):67986-68001
|
|
| 67. |
2016
Lee CC,Lo Y,Ho LJ,Lai JH,Lien SB,Lin LC, Chen CL, Chen TC, Liu FC*, Huang HS*.
A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes
. Plos One
.2016
;(11):e01493
|
|
| 68. |
2016
Ahmed Ali AA,Chen TC,Lee YR,Chen CL,Lee CC,Shiau CY, Chiang CH, Huang HS*.
Novel Anthra[1,2-c][1,2,5]thiadiazole-6,11-diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination
. Plos one
.2016
;(11):e01542
|
|
| 69. |
2016
Chen CL,Lee CC,Liu FL,Chen TC,Ahmed Ali AA,Chang DM, Huang HS.
Design, synthesis and SARs of novel salicylanilides as potent inhibitors of the RANKL-induced osteoclastogenesis and bone resorption
. Eur. J. Med. Chem.
.2016
;(117):70-84
|
|
| 70. |
2015
Lee YR,Chen TC,Lee CC,Chen CL,Ahmed Ali AA,Tikhomirov A, Guh JH, Yu DS, Huang HS.
Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole -6,11-dione derivatives as promising scaffold of antitumor agents
. Euro J Med Chem
.2015
;(102):661-676
|
|
| 71. |
2015
Chen TC,Wu CL,Lee CC,Chen CL,Yu DS,Huang HS*.
Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents
. Eur. J. Med. Chem.
.2015
;(103):615-627
|
|
| 72. |
2015
Lee CC,Liu FL,Chen CL,Chen TC,Chang DM,Huang HS.
Discovery of 5-(2',4'-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis
. Eur. J. Med. Chem.
.2015
;(98):115-126
|
|
| 73. |
2015
Lee CC,Liu FL,Chen CL,Chen TC,Liu FC,Ahmed AliAA, Chang DM, Huang HS.
Novel inhibitors of RANKL-induced osteoclastogenesis: Deign, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)- diones
. Bioorg. Med. Chem.
.2015
;(23):4522-4532
|
|
| 74. |
2014
Tang SH,Huang HS,Wu HU,Tsai YT,Chuang MJ,Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS, Cha TL.
Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in Vitro and in Vivo
. Oncotarget
.2014
;(5):1-14
|
|
| 75. |
2014
Chen YW,Huang HS,Shieh YS,Ma KH,Huang SH,Hueng DY, Sytwu HK, Lin GJ.
A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo
. Plos One
.2014
;(9):104703
|
|
| 76. |
2014
Chen CL,Liu FL,Lee CC,Chen TC,Chang WW,Guh JH, Ali AAA, Chang DM, Huang HS*.
Ring Transformation Strategy for the Synthesis of Anthra[2,3-d]oxazole-2-thione-5,10-dione Homologues as DNA Topoisomerase Inhibitors and as Antitumor Agents
. Eur. J. Med. Chem.
.2014
;(87):30-38
|
|
| 77. |
2014
Chen CL,Liu FL,Lee CC,Chen TC,Ahmed AAA,Sytwu HK, Chang DM, Huang HS*.
Modified salicylanilide and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption
. J. Med. Chem.
.2014
;(57):8072-8085
|
|
| 78. |
2014
Hsu JL,Liu SP,Lee CC,Hsu LC,Ho YF,Huang HS*, Guh JH*.
A unique amidoanthraquinone derivative displays anti-proliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway
. Naunyn-Schmiedeberg's Archives of Pharmacology
.2014
;(7):1-12
|
|
| 79. |
2014
Chung YL,Pan CH,Lioua WH,Sheua MJ,Lin WH,Chen TC, Huang HS, Wu CH*.
NSC746364, a G-quadruplex stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of ATR/Chk1-dependent pathway
. J. Pharmacol. Sci.
.2014
;(124):7-17
|
|
| 80. |
2014
Liou JT,Huang HS,Chiang ML,Lin CS,Yang SP,Ho LJ, Lai JH*.
A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells
. Eur. J. Pharmacol.
.2014
;(726):124-132
|
|
| 81. |
2013
Lee CC,Chang DM,Huang KF,Chen CL,Chen TC,Lo Y, Guh JH*, Huang HS*.
Design, Synthesis and Antiproliferative Evaluation of Fluorenone Analogs with DNA Topoisomerase I Inhibitory Properties
. Bioorg. Med. Chem.
.2013
;(21):7125-7133
|
|
| 82. |
2013
Chen TC,Yu DS,Huang KF,Fu YC,Chen CL,Lee CC, Huang FC, Hsieh HH, Lin JJ*, Huang HS*.
Structure-based Design, Synthesis and Biological Evaluation of Novel Anthra[1,2-d]imidazole-6,11-dione Homologues as Potential Antitumor Agent
. Eur. J. Med. Chem.
.2013
;(69):278-293
|
|
| 83. |
2013
Liou WS,Hsieh SC,Chang WY,Wu HM,Huang HS,Lee CF*.
Brand name or generic? What Are the Health Professionals Prescribed for Treating Diabetes? A Longitudinal Analysis of the National Health Insurance Reimbursement Database
. Pharmacoepidemiol Drug Saf., 2013, 10.1002/pds.3445.
.2013
;(10):1002
|
|
| 84. |
2013
Wang CH,Huang HS,Dai NT,Sheu MJ,Chang DM*.
Ascorbigen Induces Dermal Papilla Cell Proliferation in Vitro, but Fails to Modulate Chemotherapy-Induced Alopecia in Vivo
. Phytotherapy Research
.2013
;(3):doi: 1
|
|
| 85. |
2013
Lee YR,Yu DS,Liang YC,Huang KF,Chou SJ,Chen TC, Lee CC, Chen CL, Chiou SH*, Huang HS*.
New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cell Lines and Cancer Stem-like Cells caused by Some Selected Anthraquinone-derived Small Molecules
. Plos One
.2013
;(2):e56284
|
|
| 86. |
2013
Chen CL,Chang DM,Chen TC,Lee CC,Hsieh HH,Huang FC, Huang KF, Guh JH, Lin JJ*, Huang HS*.
Structure-based Design, Synthesis and Evaluation of Novel Anthra[1,2-d]imidazole-6,11-dione Derivatives as Telomerase Inhibitors and Potential for Cancer Polypharmacology
. Eur. J. Med. Chem.
.2013
;(60):29-41
|
|
| 87. |
2012
Lee CC,Huang KF,Chang DM,Hsu JJ,Huang F C,Shih KN, Chen CL, Chen TC, Chen RH, Lin JJ*, Huang HS*.
Design, Synthesis and Evaluation of Telomerase Inhibitory, hTERT Repressing, and Anti-proliferation Activities of Symmetrical 1,8-disubstituted Amidoanthraquinones
. Eur. J. Med. Chem.
.2012
;(50):102-112
|
|
| 88. |
2012
Lee CC,Huang KF,Lin PY,Huang FC,Chen CL,Chen TC, Guh JH, Lin JJ*, Huang HS*.
Synthesis, Antiproliferative Activities and Telomerase Inhibition Evaluation of Novel Asymmetrical 1,2-Disubstituted Amidoanthraquinone Derivatives
. Eur. J. Med. Chem.
.2012
;(47):322-336
|
|
| 89. |
2012
Huang F C,Huang KF,Chen RH,Wu JE,Chen TC,Chen CL, Lee CC, Chen JY, Lin JJ*, Huang HS*.
Synthesis, Telomerase Evaluation and Anti-proliferative Studies on Various Series of Diaminoanthraquinone-linked Aminoacyl Residues Derivative
. Arch. Pharm.
.2012
;(345):101-111
|
|
| 90. |
2012
Cheng CP,Huang HS,Hsu YC,Sheu MJ,Chang DM.
Benzamide-linked Small Molecule NDMC101 Inhibits NFATc1 and NF-κB Activity: a Potential Osteoclastogenesis Inhibitor for Rheumatoid Arthritis
. J. Clin. Immunol.
.2012
;(32):762-777
|
|
| 91. |
2012
Cheng MH,Yang Y C,Wong YH,Chen TR,Lee CY,Yang CC, Chen SH, Yang IN, Yang YS, Huang HS, Yang CY, Huang MS, Chiu H.
B1, A Novel Topoisomerase II Inhibitor, Induces Apoptosis and Cell Cycle G1 Arrest in Lung Adenocarcinoma A549 Cells .
. Anti-Cancer Drugs
.2012
;(23):191-199
|
|
| 92. |
2011
Chang YL,Lee HJ,Liu ST,Lin YS,Chen TC,Hsieh TY*, Huang HS*, Huang SM*.
Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin
. Int. J. Biochem. Cell Biol.
.2011
;(43):1720-1728
|
|
| 93. |
2011
Chang CJ,Hsu CC,Chang CH,Tsai LL,Chang YC,Lu SW, Yu CH, Huang HS, Wang JJ, Tsai CH, Chou MY, Yu CC, Hu FW.
Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer
. Oncol. Rep.
.2011
;(26):1003-1010
|
|
| 94. |
2011
Liu FC,Huang HS,Huang CY,Ro Y,Chang DM,Lai JH, Ho LJ*.
A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced Interferon Regulatory Factor-1 in porcine chondrocytes: A potential disease-modifying drug for osteoarthritis therapeutics
. J. Clin. Immunol.
.2011
;(31):1131-1142
|
|
| 95. |
2011
Chiang CH,Chang CC,Huang HC,Tsai PH,Jeng SY,Hung SI, Liang YC, Huang HS, Chiou SH, Lee FY, Lee SD, Yuan CC, Hsieh JH.
Investigation of hepatoprotective activity of induced pluripotent stem cells in the mouse model of liver injury
. J. Biomed. Biotechnol.
.2011
;(2011):219060
|
|
| 96. |
2011
Shchekotikhin A,Glazunova VA,Dezhenkova LG,Shevtsova EK,Traven VF,Balzarini J, Huang HS, Shtil AA, Preobrazhenskaya MN.
The first series of 4,11-bis[(2-aminoethyl)amino]anthrax[2,3-B]furan-5,10-diones: synthesis and anti-proliferative characteristics
. Eur. J. Med. Chem.
.2011
;(46):423-428
|
|
| 97. |
2010
Huang HS,Huang KF,Lee CC,Chen CL,Li CL,Lin JJ.
NSC 746364, NSC 746365 and NSC 746366: the spectra of cytotoxicity and molecular correlates of response to telomerase activity
. Anti-Cancer Drugs
.2010
;(21):169-180
|
|
| 98. |
2010
Dutikova YuV,Borisova ОF,Shchyolkina AК,Lin JJ,Huang HS,Shtil AA, Kaluzhny DN.
5,10,15,20-Tetra-(N-methyl-3-pyridyl)porphyrin destabilizes the anti-parallel telomeric quadruplex d(TTAGGG)4
. Molecular Biology
.2010
;(44):823-831
|
|
| 99. |
2010
Chou YS,Horng CT,Huang HS,Chen JT,Tsai ML.
Reactive Arthritis following Streptococcus viridian Urinary Tract Infection
. Ocul. Immunol. Inflamm.
.2010
;(18):41-42
|
|
| 100. |
2009
Huang HS*,Chen JC,Chen RH,Huang KF,Huang FC,Jhan JR, Chen CL, Lo Y, Lee CC, Lin JJ*.
Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole -6,11-dione homologues
. Bioorg. Med. Chem.
.2009
;(17):7418-7428
|
|
| 101. |
2009
Shchekotikhin AE,Glazunova VA,Dezhenkova LG,Luzikov YN,Sinkevich YB,Kovalenko LV, Buyanov VN, Balzarini J, Huang FC, Lin JJ, Huang HS, Shtil AA, Preobrazhenskaya MN.
Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra-[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones
. Bioorg. Med. Chem.
.2009
;(17):1861-1869
|
|
| 102. |
2008
Huang HS*,Huang KF,Li CL,Huang YY,Chiang YH,Huang FC, Lin JJ*.
Synthesis, Human Telomerase Inhibition and Antiproliferative Studies of a Series of 2,7-Bis-substituted Amido-anthraquinone Derivatives
. Bioorg. Med. Chem.
.2008
;(16):6976-6986
|
|
| 103. |
2007
Cheng KT,Hsu FL,Chen SH,Hsieh PK,Huang HS,Lee CK, Lee MH*.
New constituent from Podocarpus macrophyllus var. macrophyllus shows anti-tyrosinase effect and regulates tyrosinase-related proteins and mRNA in human epidermal melanocytes
. Chem. Pharm. Bull.
.2007
;(55):757-761
|
|
| 104. |
2007
Huang HS*,Chen IB,Huang KF,Lu WC,Shieh FY,Huang YY, Huang FC, Lin JJ*.
Synthesis and Human Telomerase Inhibition of a Series of Regioisomeric Disubstituted Amidoanthraquinones
. Chem. Pharm. Bull.
.2007
;(55):284-292
|
|
| 105. |
2007
Huang HS*,Lin JJ,Huang KF,Li CL.
A Concise Paradigm for the Construction of Amide Linker of 2,7-Diamidoanthraquinone Derivatives as Potential Telomerase Inhibitors
. Taiwan Pharm. J.
.2007
;(59):179-187
|
|
| 106. |
2006
Preobrazhenskaya M,Shchekotikhin AE,Shtil AA,Huang HS*.
Antitumor Anthraquinone Analogues for Multidrug Resistant Tumor Cells
. J. Med. Sci.
.2006
;(26):1-4
|
|
| 107. |
2006
Huang HS*,Chiu HF,Tao CW,Chen IB.
Synthesis and Antitumor Evaluation of Symmetrical 1,5-Diamidoanthraquinone Derivatives as Compared to their Disubstituted Homologues
. Chem. Pharm. Bull.
.2006
;(54):458-464
|
|
| 108. |
2006
Preobrazhenskaya M,Tevyashova AN,Olsufyeva EN,Huang KF,Huang HS*.
Second Generation Drugs-derivatives of Natural Antitumor Anthracycline Antibiotics Daunorubicin, Doxorubicin and Carminomycin
. J. Med. Sci.
.2006
;(26):119-128
|
|
| 109. |
2005
Huang HS*,Chiu HF,Lu WC,Yuan CL.
Synthesis and Antitumor Activity of 1,8-Diaminoanthraquinone Derivatives
. Chem. Pharm. Bull.
.2005
;(53):1136-1139
|
|
| 110. |
2005
Huang HS*,Chou CL,Guo CL,Yuan CL,Lu YC,Shieh FY, Lin JJ.
Human Telomerase Inhibition and Cytotoxicity of Regioisomeric Disubstituted Amidoanthraquinones and Aminoanthraquinones
. Bioorg. Med. Chem.
.2005
;(13):1435-1444
|
|
| 111. |
2004
Huang HS*,Chiu HF,Lee AR,Guo CL,Yuan, CL.
Synthesis and structure-activity correlations of the cytotoxic bifunctional 1,4-diamidoanthraquinone derivatives
. Bioorg. Med. Chem.
.2004
;(12):6163-6170
|
|
| 112. |
2004
Huang HS*,Chiu HF,Yeh PF,Yuan CL.
Structure-based Design and Synthesis of Regioisomeric Disubstituted Aminoanthraquinone Derivatives as Potential Anticancer Agents
. Helvetica. Chimica. Acta.
.2004
;(87):999-1006
|
|
| 113. |
2004
Chen RF,Chou CL,Wang MR,Chen CF,Liao JF,Ho LK, Tao CW, Huang HS*.
Small-Molecule Anthracene-induced Cytotoxicity and Induction of Apoptosis through Generation of ROS
. Biol. Pharm. Bull.
.2004
;(27):838-845
|
|
| 114. |
2004
Lin LH,Huang HS,Lin CC,Lee LW,Lin PY.
Effects of Cantharidinimides on Human Carcinoma Cells
. Chem. Pharm. Bull.
.2004
;(52):855-857
|
|
| 115. |
2004
Chen RF,Shen YC,Huang HS,Liao JF,Ho LK,Chou YC, Wang WY, Chen CF*.
Evaluation of the anti-inflammatory and cytotoxic effects by anthraquinone and anthracene derivatives in human leukocytes
. J. Pharm. Pharmacol.
.2004
;(56):915-919
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| 116. |
2003
Huang HS*,Chiou JF,Fong Y,Hou CC,Lu YC,Wang JY, Shih JW, PanYR, Jeng WR, Lin JJ.
Activation of Human Telomerase Reverse Transcriptase Expression by Some New Symmetrical Bis-substituted Derivatives of the Anthraquinone
. J. Med. Chem.
.2003
;(46):3300-3307
|
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| 117. |
2002
Huang HS,Chiou J F, Chiu H F ,Chen R F ,Lai Y L.
Synthesis and Cytotoxicity of 9-Alkoxy-1,5-Dichloroanthracene Derivatives in Murine and Human Cultured Tumor Cells
. Arch Pharm
.2002
;(335):33-38
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| 118. |
2002
Huang HS,Chiou J F ,Chiu H F ,Tao C W ,Chen R F ,Jeng W R.
Synthesis of Symmetrical 1,5-Bisacyloxy Anthraquinone Derivatives and Their Dual Activity of Cytotoxicity and Lipid Peroxidation
. Arch Pharm
.2002
;(335):481-486
|
|
| 119. |
2002
Huang HS,Chiou J F ,Chiu H F ,Tao C W ,Yeh P F ,Jeng W R.
Synthesis of Symmetrical 1,5-Bisthiosubstituted Anthraquinones for Cytotoxicity in Cultured Tumor Cells and Lipid Peroxidation
. Chem. Pharm. Bull.
.2002
;(50):1491-1494
|
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| 120. |
2001
Huang HS,Hwang J M ,Jen Y M ,Lin J J ,Lee K Y ,Shi C H, Hsu H C.
Studies on Anthracenes. 1. Human Telomerase Inhibition and Lipid Peroxidation of 9-Acyloxy 1,5-Dichloroanthracene Derivatives
. Chem. Pharm. Bull.
.2001
;( 49):969-973
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| 121. |
2001
Huang HS,Chiu H F ,Hwang J M ,Jen Y M ,Tao C W ,Lai Y L.
Studies on Anthracenes.2. Synthesis and Cytotoxic Evaluation of 9-Acyloxy 1,8-Dichloroanthracene Derivatives
. Chem. Pharm. Bull.
.2001
;(49):1346-1348
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| 122. |
2001
Huang HS,Lin P Y ,Hwang J M ,Hsu H C ,Lai Y L ,Tao C W .
Studies on Anthracenes. 3. Synthesis, Lipid Peroxidation and Cytotoxic Evaluation of 10-Substituted 1,5-Dichloro-9(10H)-anthracenone Derivatives
. Chem. Pharm. Bull.
.2001
;(49):1288-1291
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| 123. |
1997
Müller K,Prinz H ,Gawlik I ,Ziereis K ,Huang HS.
Simple Analogs of Anthralin: Unusual Specificity of Structure and Antiproliferative Activity
. J. Med. Chem.
.1997
;(40):3773-3780
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| 124. |
1996
Müller K,Huang HS,Wiegrebe W.
Antipsoriatic Anthrones with Modulated Redox Properties. 3. 10-Thio-Substituted 1,8-Dihydroxy-9(10H)- anthracenone as Inhibitors of Keratinocyte Growth, 5-Lipoxygenase, and the Formation of 12(S)-HETE in Mouse Epidermis
. J. Med. Chem.
.1996
;(39):3132-3138
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| 125. |
1995
Electron-impact Induced and Thermal Decomposition of Dithranol Derivatives, III: Fragmentations of 10-Alkoxy- and 10-Benzyloxy-Dithranol Radical Cations
. Arch Pharm
.1995
;(328):297-299
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| 126. |
1994
Electron-impact Induced and Thermal Decomposition of Dithranol Derivatives, I: Thermolysis of 10-Phenylthio-dithranol in the Mass Spectrometer
. Arch Pharm
.1994
;(327):669-671
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| 127. |
1994
Electron-impact Induced and Thermal Decomposition of Dithranol Derivatives, II: Multiple H-Rearrangements in 10-Benzylthio-dithranol Radical Cations
. Arch Pharm
.1994
;(327):735-738
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| 128. |
1994
A Convenient Synthesis of 14C-Anthralin
. Arch Pharm
.1994
;(327):743-744
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| 129. |
1989
Synthesis of Ethyl 4(1H)-Oxopyrimido[1,2-a] perimidine-3- carboxylate
. Arch Pharm
.1989
;(322):303-304
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| 130. |
1988
Synthesis and Biological Evaluation of Some 1-Substituted 3-(2-Perimidyl)ureas
. Arch Pharm
.1988
;(321):425-426
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| 131. |
1988
Synthesis of Methyl 4(1H)-Oxopyrimido[1,2-a]perimidine-2- carboxylate
. Arch Pharm
.1988
;(321):771-772
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