吳姿樺(Wu, Tzu-Hua) 教授

Email
thwu@tmu.edu.tw
現   職
臨床藥學學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
美國麻省藥學院(MCPHS)藥學研究所 博士
1996/09~1998/05
美國麻省藥學院藥學研究所 碩士
1993/09~1996/05
中國醫藥學院藥學系 學士
1986/09~1991/06

本校學術經歷

任職單位與職稱[起迄時間]
臨床藥學學科教授
2016/08/01~
臨床藥學學科副教授
2012/02/01~2016/07/31
藥學系副教授
2008/08/01~2012/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程教授
2020/04/01 ~
(舊)生技醫療產業研發博士學位學程副教授
2016/09/01 ~ 2017/08/31

其它經歷

任職單位與職稱[起迄時間]
大仁技術學院助理教授
2000/08~2002/07
台灣大學生化研究所博士後研究員
1999/08/01~2000/07/31
中央研究院生化所博士後研究員
1998/08/01~1999/07/31

專長與研究領域

學門領域
藥物動態學 (Pharmacodynamics)
臨床藥理學暨治療學 (Clinical pharmacology and therapeutics)
精神與行為科學 (Behavioral neuroscience)
神經藥理 (Neuropharmacology)
藥理及毒理
療劑監測與藥物動力學 (Therapeutic drug monitoring and Pharmacokinetics)
學術專長
腦部微透析技術 (Microdialysis)
莫瑞斯迷宮 (Morris water maze)
藥物分析_電化學分析(HPLC-ECD)
蛋白質化學相關技術
抗白內障活性測試 (Anticataratogenic Bioassays)
臨床樣品分析相關技術

論文著作

清冊下載


1. 2022 Goh, K. K.,Chen, C. Y. A.,Wu, T. H.,Chen, C. H.,Lu, M. L.. Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction. . International Journal of Molecular Sciences .2022 ;(23):7092

2. 2022 Lu ML,Ku WC,Syifa N,Hu SC,Chou CT,Wu YH, Kuo PH, Chen CH, Chen WJ, Wu TH*. Developing a Sensitive Platform to Measure 5-Methyltetrahydrofolate in Subjects withMTHFR and PON1 Gene Polymorphisms. . Nutrients. .2022 ;(14):3320

3. 2022 Goh KK,Chen CH ,Wu TH,Chiu YH,Lu ML. Efficacy and safety of intermittent theta-burst stimulation in patients with schizophrenia: A meta-analysis of randomized sham-controlled trials. . Front Pharmacol . .2022 ;(13):944437

4. 2021 Hung YC,Chen HC,Kuo PH,Lu ML,Huang MC,Chen CH, Wang S, Mao WC, Wu CS, Wu TH*. Visualizing Patterns of Medication Switching Among Major Depressive Patients with Various Stability and Difficulty to Treatments. . Neuropsychiatric Disease Treatment .2021 ;(17):1953-1963

5. 2021 Goh KK,Wu TH,Chen CH,Lu ML. . Efficacy of N-methyl-D-aspartate receptor modulator augmentation in schizophrenia: A meta-analysis of randomised, placebo-controlled trials. . J Psychopharmacol. .2021 ;(35):236-252.

6. 2021 Wu TH ,Lin CH,Goh KK,Chen YA,Lane HY,Lu ML. The relationships between hyperprolactinemia, metabolic disturbance, and sexual dysfunction in patients with schizophrenia under olanzapine treatment. . Frontiers in Pharmacology .2021 ;(12):718800--

7. 2020 Liu TY,Kuo PH,Lu ML,Huang MC,Chen CH,Wu TH, Wang S, Mao WC, Chen HC*. Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale . PLoS One .2020 ;(15):e0227614

8. 2020 Syifa N,Yang JT,Wu CS,Lin MH,Wu WL,Lai CW, Ku SH, Liang SY, Hung YC, Chou CT, Wang CS, Ishihama Y, Liao JH, Wu SH*, Wu TH*. Phosphoproteomics and Bioinformatics Analyses Reveal Key Roles of GSK-3 and AKAP4 in Mouse Sperm Capacitation. . Int J Mol Sci. .2020 ;(21):7283--

9. 2019 Wang YC,Lin HT,Lu ML,Huang MC,Chen CH,Wu TH, Wang S, Mao WC, Kuo PH, Chen HC*. The Association Between the Sedative Loads and Clinical Severity Indicators in the First-Onset Major Depressive Disorder . Frontier in Psychiatry .2019 ;(10):129

10. 2019 Wu TH,Chiu CC,Chen PY,Huang MC,Chen CH,Shen WW, Lu ML*. Obsessive-compulsive symptoms in patients with schizophrenia: relationships with olanzapine pharmacological parameters, psychopathology, and quality of life . Psychiatry Research .2019 ;(276):1-5

11. 2019 Wu TH,Chiu CC,Goh KK,Chen PY,Huang MC,Chen CH, Lu ML*. Relationship between metabolic syndrome and acylated/desacylated ghrelin ratio in patients with schizophrenia under olanzapine medication. . Jounal of psychopharmacology .2019 ;(34):86-92

12. 2019 Wu CS*,Chen YH,Chen CL,Chien SK,Syifa N,Hung YC, Cheng KJ, Hu SC, Lo PT, Lin SY, Wu TH*. Constructing a Bilingual Website with Validated Database for Herb and Western Medicine Interactions using Ginseng, Ginkgo and Dong Quai as Examples . BMC Complementary and Alternative Medicine .2019 ;(19):335

13. 2018 Lu ML,Chen CH,Kuo PT,Lin CH,Wu TH*. Application of plasma levels of olanzapine and N-desmethyl-olanzapine to monitor metabolic parameters in patients with schizophrenia . Schizophrenia Research .2018 ;(193):139-145

14. 2018 Lu CP,Huang CY,Wang SH,Chiu CH,Li LH,Hua KF*, Wu TH*. Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin. . Chem Biol Interact. .2018 ;(290):12-18

15. 2017 Lin HC,Lin MH,Liao JH,Wu TH,Lee TH,Mi FL, Wu CH, Chen KC, Cheng CH, and Lin CW. Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets . J. Agric. Food Chem. .2017 ;(65):51-59

16. 2017 Lu MY,Lin TH,Chiang PH,Kuo PH,Wang N,Wu WH, Lin KH, Wu TH*. Deferasirox-Iron Complex Formation Ratio as an Indicator of Long-term Chelation Efficacy in β-Thalassemia Major. . Therapeutic Drug Monitoring .2017 ;(39):185-191

17. 2016 Liao JH,Huang YS,Lin YC,Huang FY,Wu SH,Wu TH*. Anti-cataractogenesis Mechanisms of Curcumin and a Comparison of its Degradation . J Agric Food Chem .2016 ;(64):2080-2086

18. 2016 Lu ML,Wu YX,Chen CH,Kuo PT,Chen YH,Lin CH, Wu TH. Application of Plasma Levels of Olanzapine and N-Desmethyl-Olanzapine to Monitor Clinical Efficacy in Patients with Schizophrenia. . PLOS ONE .2016 ;(11):e01485--

19. 2015 Chen YC,Pan LC,Lai CW,Chien YS,Wu TH*. Silymarin and protein kinase A inhibitor modulate glucose-mediated mouse sperm motility: an in vitro study . Reproductive Biology .2015 ;(15):172-177

20. 2015 Lu MY,Wang N,Wu WH,Lai CW,Kuo PH,Chiang PH, Lin KH, Wu TH*. Simultaneous determination of plasma deferasirox and iron-deferasirox complex using an HPLC-UV system and pharmacokinetics of deferasirox in patients with β-thalassemia major: once-daily versus twice-daily administration . Clinical Therapeutics .2015 ;(37):1751-1760

21. 2015 Liao JH,Wu TH(1st Equal),Chen MY,Chen WT,Lu SY,Wang YH, Wang SP, Hsu YM, Huang YS, Huang ZY, Lin YC, Chang CM, Huang FY, Wu SH. The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions . Scientific Reports_proof received .2015

22. 2014 Liao JH,Lin IL,Huang KF,Kuo PT,Wu SH,Wu TH*. Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C induced degradation . JAFC .2014 ;(62):5932-5938

23. 2013 Lu ML,Lin CH,Chen YC,Yang HC,Wu TH. Determination of olanzapine and N-desmethyl-olanzapine in plasma using a reversed-phase HPLC coupled with coulochemical detection: correlation of olanzapine or N-desmethyl-olanzapine concentration with metabolic parameters . PLOS ONE .2013 ;(8(5)):1-7

24. 2013 Yeh MI,Huang HC,Liaw JH,Huang MC,Wu TH,Huang KF, Hsu FL. Ethosomes in hair dye products as carriers of the major compounds of black tea . Int J Dermatol. .2013 ;(52):868-875

25. 2013 Wu TH,Chien YS,Wang WF,Hsu KY,Sheu SY. Implementation and Outcomes of Community Pharmacy Practicum . THE JOURNAL OF TAIWAN PHARMACY .2013 ;(29):8-12

26. 2012 Chang SC,Lu ML,Wang YC,Lin FW,Huang SH,Kuo PH, Ho HO, Wu TH. Combined Therapy with Thioridazine Decreases Plasma Levels of Quetiapine in Taiwanese Schizophrenic Patients. . Therapeutic Drug Monitoring .2012 ;(34):345-348

27. 2012 Chou YC,Chen CL,Wu TH. Medical device on pharmacists' work-related musculoskeletal complaints and burnouts. . Ergonomics .2012 ;(55):1420-1428

28. 2012 Hsu FL,Huang WJ,Wu TH,Lee MH,Chen LC,Lu HJ, Hou WC, Lin MH. Evaluation of Antioxidant and Free Radical Scavenging Capacities of Polyphenolics from Pods of Caesalpinia Pulcherrima . Int. J. Mol. Sci. .2012 ;(13):6073-6088

29. 2012 Hua KF,Wang SH,Dong WC,Lin CY,Ho CL,Wu TH*. High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-alpha/delta and NF-kappaB . Inflammation Research .2012 ;(61):1107-1116

30. 2011 Hu CC,Liao JH,Hsu KY,Lin IL,Tsai MH,Wu WH, Wei TT, Huang YS, Chiu SJ, Chen HY, Wu SH and Wu TH. Role of Pirenoxine in the Effects of Catalin on in vitro Ultraviolet-induced Lens Protein Turbidity and Selenite-induced Cataractogenesis in vivo. . Molecular Vision .2011 ;(17):1862-1870

31. 2011 Lin MH,Liu HK,Huang WJ,Hunang CC,Wu TH,Hsu FL. Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from Corni fructus to tackle insulin-dependent diabetes mellitus. . J. Agric. Food Chem .2011 ;(59):7743-7751

32. 2011 Liao JH,Wu TH,Hsu FL,Huang YS,Chiang PH,Huang ZY, Huang CH, Wu SH*, Lin MH*. Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: an Implications for Anti-cataract Agent. . International Journal of Molecular Sciences .2011 ;(12):7059-7076

33. 2011 Liao JH,Chen CS,Hu CC,Chen WT,Wang SP,Lin IL, Huang YH, Tsai MH, Wu TH*, Huang FY, Wu SH. Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis. . Inorganic Chemistry .2011 ;(50):365-377

34. 2010 Wu TH*,Liao JH,Hsu FL*,Wu HR,Shen CK,Yuann JM, Chen ST. Grape Seed Proanthocyanidin Extract Chelates Iron and Attenuates the Toxic Effects of 6-Hydroxydopamine: implications for Parkinsons's Disease . Journal of Food Biochemistry (DOI: 10.1111/j.1745-4514.2009.00276.x) .2010 ;(34):244-262

35. 2010 Liao JH,Lin YC,Hsu J,Lee AY,Chen TA,Hsu CH, Chir JL, Hua KF, Wu TH, Hong LJ, Yen PW, Chiou A, Wu SH. Binding and cleavage of E. coli HUbeta by the E. coli Lon protease. . Biophysical Journal .2010 ;(98):129-137

36. 2009 Liao JH,Chen CS,Maher JH,Liu CY,Lin MH,Wu TH*, Wu SH*. Astaxanthin Interacts with Selenite and Attenuates Selenite-Induced Cataractogenesis. . Chem. Res. Toxicol. .2009 ;(22):518-525

37. 2008 Wu TH,Chiu CC,Shen WW,Lin FW,Wang LH,Chen HY, Lu ML. Pharmacokinetics of olanzapine in Chinese male schizophrenic patients with various smoking behaviors. . Prog Neuropsychopharmacol Biol Psychiatry. .2008 ;(32):1889-1893

38. 2008 Chen CH,Chiu CC,Huang MC,Wu TH,Liu HC,Lu ML. Metformin for Metabolic Dysregulation in Schizophrenic Patients Treated with Olanzapine. . Progress in Neuro-Psychopharmacology and Biological Psychiatry .2008 ;(32):925-931

39. 2007 Chen CS,Wu SH,Wu YY,Fang JM,Wu TH*. Properties of Astaxanthin/Ca2+ Complex Formation in the Deceleration of cis/trans Isomerization. . Organic Letters .2007 ;(9):2985-2988

40. 2007 Chen CL,Wu TH,Chang YL,Chou YC,Cheng H,Tsai LA, Chun MH. Assessment of Pain Control in Patients with Spinal Cord Injuries. . Journal of Hospital Pharmacy .2007 ;(24):6-10

41. 2006 Wu, T.-H,Liao, J.-H.,Hou, W.-C,Huang, F.-Y.,Maher, T. J.,Hu, C.-C.. Astaxanthin Protects against Oxidative Stress and Calcium-induced Porcine Lens Protein Degradation . J. Agric. Food Chem. .2006 ;(54):2418-2423

42. 2006 Chang MT,Wu TH*,Wang CY,Jang TN,Huang CY. The Impact of an Intensive Antimicrobial Control Program in a Taiwanese Medical Center. . Pharmacy World Science .2006 ;(28):257-264

43. 2006 Chen CJ,Tsai CC,Hsieh JF,Chien CM,Wu TH,Chen ST. A Screening Platform for Compounds with Potential Immuno-Regulatory Activities Using Human Cord Blood Mononuclear Cells. . Combinatorial Chemistry & High Throughput Screening .2006 ;(9):777-784

44. 2002 Lin TC, Nishikawa K, Wu TH and Ishimaru K. Antioxidative and free radical scavenging activities of phenolics from Scutellaria baicalensis. . The Chinese Pharmaceutical Journal .2002 ;(54):193-198

45. 2001 Lin TC, Yamada S, Wu TH and Ishimaru K. Growth rate and polyphenol production in transformed root cultures of Fragaria x ananassa in phytohormone-free BF liquid medium. . The Chinese Pharmaceutical Journal .2001 ;(53):225-232

46. 2000 Johnson DA, Wu TH, Li PK and Maher TJ. The effects of steroid sulfatase inhibition on learning and memory. . Brain Research .2000 ;(865):286-290

47. 1996 Sheu JH, Sung PJ, Huang LH, Lee SF, Wu TH, Chang BY, Duh CY, Fang LS, Soong K and Lee TJ. New Cytotoxic Briaran Diterpenes from the Formosan Gorgonian Briareum sp.. . Journal of Natural Products .1996 ;(59):935-938


1. 2016 Liao JM,Chiu SF,Hung YC,Wu CH,Wu TH*. Impact of Pharmacy-initiated Checking Principle on Patients’Waiting Time in Community Pharmacy . .2016

2. 2015 Lo TW,Wu TH*. Teaching ethics in pharmacy practice utilizing a team-base and scenario-based assignment . .2015

3. 2006 Huang SH,Lu ML,Wu TH. Metabolic effects of quetiapine and the modulation role of silymarin in schizophrenia patients. . TMU Annual conference, 2006 .2006

4. 2005 Huang CY,Lee YH,Chang MT,Wu TH. Effects of Silymarin on Hyperglycemia: from basic research to clinic . 93 Annual Joint Conference Proceedings .2005

5. 2004 Chang MT,Wu TH,Wang CY. Impact of Intensive Antibiotic Control Program in a Medical Center . 2004 Annual meeting of Pharmaceutical Society of Republic of China. .2004

6. 2004 Huang CY,Shern CK,Lin CH,Chang MT,Lin HC,Tsai CY, Wang CY and Wu TH. Utilization of silymarin by diabetic patients: an evaluation study. . 2004 Annual meeting of Pharmaceutical Society of Republic of China. .2004

7. 2003 Wu HR,Sinchaikul S,Chen ST,Wu TH. Cytotoxic Effects of Grape Seed Proanthocyanidins on Cultured Human HEP G2 Cells: a Proteomic Study . 2003 annual meeting of Pharmaceutical Society of Republic of China .2003

8. 1996 Wu, TH, Acworth IN and Maher TJ. Effects of body temperature manipulations on striatal extracellular dopamine levels as determined using in vivo microdialysis. . .1996

研究計畫

計畫名稱
113 評估急重症就診病人營養元素缺乏型態及藥物治療成效(1/3)
補助單位
國家科學及技術委員會

計畫名稱
111 以療劑監測與體學技術探討泌乳激素調控因子及病情控制
補助單位
國家科學及技術委員會

計畫名稱
109 刺蒺藜與潼蒺藜粗萃對精子活性差異與鋅鎂濃度的影響
補助單位
科技部

計畫名稱
109 枸杞多醣對鐵沉積及其相關病症之影響
補助單位
科技部

計畫名稱
108 探討酵素基因多型性變異及生化營養指標對接受鐵螯合治療之重型海洋性貧血病人心臟鐵質沉積控制成效的影響
補助單位
科技部

計畫名稱
108 憂鬱症之單碳代謝與糖原合成酵素激?3β訊息失調及刺蒺藜果實成份之影響
補助單位
科技部

計畫名稱
108 貴校藥學系(所)碩士班研究生蔡宛芙君擬於108年9月9日至9月13日赴日本京都參加國際鋅生物學會第六屆會議,依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案
補助單位

計畫名稱
107 精子獲能反應之磷酸化蛋白質體分析以及中藥調控機制之探討(3/3)
補助單位
科技部

計畫名稱
107 貴校博士生Nailis君擬於108年7月26日至7月30日赴美國波士頓參加發展生物學會第78屆年會
補助單位

計畫名稱
106 精子獲能反應之磷酸化蛋白質體分析以及中藥調控機制之探討(2/3)
補助單位
科技部

計畫名稱
106 貴校藥學系碩士班研究生王建升君擬於106年9月10日至9月14日赴南韓首爾(Seoul)參加第77屆世界藥學會
補助單位
科技部

計畫名稱
105 精子獲能反應之磷酸化蛋白質體分析以及中藥調控機制之探討(1/3)
補助單位
科技部

計畫名稱
105 精子獲能反應之磷酸化蛋白質體分析以及中藥調控機制之探討(1/3)
補助單位

計畫名稱
104 薑黃素及其衍生物延緩白內障形成活性與生化機制
補助單位
科技部

計畫名稱
104 104 年9 月赴德國杜塞爾多夫(Duesseldorf)參加The International Pharmaceutical Federation (FIP)
補助單位

計畫名稱
103 比較不同鋅化合物對精子磷酸化蛋白質之影響
補助單位
科技部

計畫名稱
103 運用小鼠鐵沉積模式來探究鋅對鐵代謝及精子功能異常問題之影響
補助單位
臺北醫學大學

計畫名稱
102 Deferasirox血中濃度檢測及具排鐵潛力食品藥物對鐵質沉積指標之影響與安全性分析
補助單位
行政院國家科學委員會

計畫名稱
102 DEFERASIROX血中濃度檢測及具排鐵潛力食品藥物對鐵質沉積指標之影響與安全性分析
補助單位
科技部

計畫名稱
101 水飛薊對殺菌劑造成精子功能異常的調節機制探討: 磷酸蛋白質體的研究
補助單位
行政院國家科學委員會

計畫名稱
100 葉黃素對雄性小鼠生殖功能損傷模式之免疫調節作用機制
補助單位
行政院國家科學委員會

計畫名稱
99 葉黃素對雄性小鼠生殖功能損傷模式之免疫調節作用機制
補助單位
行政院國家科學委員會

計畫名稱
98 葉黃素對雄性小鼠生殖功能損傷模式之免疫調節作用機制
補助單位
行政院國家科學委員會

計畫名稱
97 加強中藥用藥安全與藥事服務品質教育計畫
補助單位
行政院衛生署中醫藥委員會

計畫名稱
95 蝦紅素保護眼球水晶體蛋白質之生化機轉研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
93 蝦紅素對眼球水晶體蛋白質的影響
補助單位
行政院國家科學委員會

計畫名稱
92 葡萄子花前青素對巴金森氏症細胞模式的影響及生化路徑的探討
補助單位
行政院國家科學委員會

計畫名稱
91 葡萄子之花青素萃取物對人類肝癌細胞之影響
補助單位
臺北醫學大學