林佑穗(Lin, You-Shuei)　教授

Email
yslin@tmu.edu.tw
現   職
生理學科 教授

學經歷

學　歷

畢業學校與學位[修業時間]
國立陽明大學生理學研究所 博士
1994/09/01~2000/06/01
私立臺北醫學院保健營養學系 學士
1990/09/01~1993/06/01

本校學術經歷

任職單位與職稱[起迄時間]
生理學科教授
2022/08/01~
生理學科副教授
2010/02/01~2022/07/31
生理學科助理教授
2002/08/01~2010/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學科學研究所助理教授
2007/08/01 ~
神經科學研究所助理教授
2006/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
美國肯塔基大學生理系研究員
2000/08/01~2002/07/25

專長與研究領域

學門領域
肺病理生理學 (Pulmonary Pathophysiology)
神經電生理學 (electroneurophysiology)
學術專長
Measurement of respiratory cardiovascular parameters
Single fiber recording

論文著作

清冊下載

論文 Journal Paper


1. 2024 You Shuei Lin, Nai‐Ju Chan,Pei‐Yu Xiao, Ching Jung Lai. Stimulatory effect of methylglyoxal on capsaicin-sensitive lung vagal afferents in rats: role of TRPA1 . Am J Physiol Regul Integr Comp Physiol .2024

2. 2023 Shiao-Ya Hong, Chih-Cheng Lai,, Nai-Chi Teng,Chao-Hsien Chen,Chun-Chun Hsu,,Nai-Ju Chan, Cheng-Yi Wang, Ya-Hui Wang, You Shuei Lin. Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies . Front Med (Lausanne) .2023

3. 2023 Chan NJ,Hsu CC,Lin YS,Lin RL,Lee LY. Inhibitory Effect of Sulfur Dioxide Inhalation on Hering-Breuer Inflation Reflex in Mice: Role of Voltage-Gated Potassium Channels . J Appl Physiol .2023

4. 2022 Lin YS,Hsu CC,Ruan T,Lee LY. Mechanisms Involved in the Stimulatory and Inhibitory Effects of 5-Hydroxytryptamine on Vagal Mechanosensitive Afferents in Rat Lung . Front. Physiol .2022

5. 2022 Lan SH,Lai CC,Chang SP,Hsu CC,Chen,CHWanf YH, Huang YL, Wang CY, Lin YS. Efficacy and safety of anti-interleukin-5 therapy in patients with chronic obstructivepulmonary disease: a meta-analysis of randomized, controlled trials . Journal of Microbiology, Immunology and Infection .2022

6. 2021 Chen CH,Lin HC,Wang YH,Wang CY ,Lin YS,Lai CC. The safety of nintedanib for the treatment of interstitial lung disease: A systematic review and meta-analysis of randomized controlled trials . PLoS One .2021

7. 2021 Lin YS,Liu CY,Chen PW,Wang CY,Chen HC,Tsao CW. Coenzyme Q 10 amends testicular function and spermatogenesis in male mice exposed to cigarette smoke by modulating oxidative stress and inflammation . American Journal of Translational Research .2021 ;(13):10142-10154

8. 2020 Lin YS,Shen YJ,Ou PH,Lai CJ. HIF-1α-Mediated, NADPH Oxidase-Derived ROS Contributes to Laryngeal Airway Hyperreactivity Induced by Intermittent Hypoxia in Rats . frontier in physiology .2020

9. 2020 Chan CS,Lin YS,Lin YK,Chen YC,Kao YH,Hsu CC, Chen SA, Chen YJ. Atrial arrhythmogenesis in a rabbit model of chronic obstructive pulmonary disease . Translational Research .2020

10. 2020 Chung CL,Lin YS,Chan NJ,Chen YY,Hsu CC. Hypersensitivity of Airway Reflexes Induced by Hydrogen Sulfide: Role of TRPA1 Receptors . International Journal of Molecular Sciences .2020

11. 2020 Lin YS,Huang IH,Lan SH,Chen CL,Chen YY,Chan NJ, HUs CC. Involvement of Capsaicin-Sensitive Lung Vagal Neurons and TRPA1 Receptors in Airway Hypersensitivity Induced by 1,3-β-D-Glucan in Anesthetized Rats . International Journal of Molecular Sciences .2020

12. 2019 Wang CY,Lin YS,Wang YH,Lai CC,Wang H,Chen L. Risk of sepsis among patients with COPD treated with fixed combinations of inhaled corticosteroids and long-acting Beta2 agonists . aging .2019 ;(11):6863-6871

13. 2019 Hsu CC,Ruan T,Lee LY,Lin YS. Stimulatory Effect of 5-Hydroxytryptamine (5-HT) on Rat Capsaicin-Sensitive Lung Vagal Sensory Neurons via Activation of 5-HT3 Receptors . Front. Physiol .2019 ;(10):642-647

14. 2019 Lin AH,Hsu CC,Lin YS,Lin RL,Lee LY. Mechanisms underlying the stimulatory effect of inhaled sulfur dioxide on vagal bronchopulmonary C-fibres . J Physiol .2019

15. 2019 Chun-Chun Hsu, Ting Ruan, Lu-Yuan Lee, You Shuei Lin . Stimulatory Effect of 5-Hydroxytryptamine (5-HT) on Rat Capsaicin-Sensitive Lung Vagal Sensory Neurons via Activation of 5-HT3 Receptors . Front. Physiol .2019

16. 2017 Hsu CC,Lin TS,Lin RL,Lee LY. Immediate and delayed potentiating effects of tumor necrosis factor-alpha on TRPV1 sensitivity of rat vagal pulmonary sensory neurons . The American Journal of Physiology-Lung Cellular and Molecular Physiology .2017 ;(313):293-304

17. 2016 Fan WJ,Chen SC,Lai CH,Lin YS,Peng CW,Kou YR. Influence of serotonergic mechanisms on the urine flow rate in male rats . Am. J. Physiol. Regul. Integr. Comp. Physiol. .2016 ;(307):1239-1250

18. 2016 Lin HW,Chung CL,Lin YS,Yu CM,Lee CN,Bein MY. Inhaled pharmacotherapy and stroke risk in patients with chronic obstructive pulmonary disease: a nationwide population based study using two-stage approach . PLoS One .2016 ;(10):013010-013010

19. 2016 Hsu CC,Lee CN,Yu CY,Lin YJP,Chiang LL,Lin YS. Airway adverse reflexes evoked by lung exposure to hydrogen sulfide: role of pulmonary C-fiber afferents and transient receptor potential ankyrin 1 receptors . Exp. Ther. Med. .2016

20. 2013 Lin YJ,Lin YS,Lai CJ,Yuan ZF,Ruan T,Kou YR. Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C-fibers to intravenous agonists . JOURNAL OF APPLIED PHYSIOLOGY .2013 ;(114):361-370

21. 2013 Weng WH,Hsu CC,Chiang LL,Lin YJP,Lin YS,Su CL. Role of TRPV1 and P2X receptors in the activation of lung vagal C-fiber afferents by inhaled cigarette smoke in rats . Molecular Medicine Reports .2013 ;(in pre)

22. 2013 Hsu CC,Lin RL,Lin YS,Lee LY. Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: role of tachykinins. . J. Appl. Physiol .2013 ;(inpres)

23. 2013 Hsu CC,Lin RL,Lee LY,Lin YS. Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors . Am. J. Physiol. Regul. Integr. Comp. Physiol .2013 ;(inpres)

24. 2013 Fan WJ,Li YT,Chen JJ,Chen SC,Lin YS,KouYR, Peng CW. Sexually dimorphic urethral activity in response to pharmacological activation of 5-HT1A receptors in the rat. . Am J Physiol Renal Physiol .2013 ;(305):1332-1342

25. 2011 Chen SC,Grill WM,Fan WJ,Kou YR,Lin YS,Lai CH, Peng CW. Bilateral Pudendal Afferent Stimulation Improves Bladder Emptying in Rats with Urinary Retention . Bristish Journal of Urology International .2011

26. 2011 Chen JC,Chuang JG,Su YY,Chiang BL,Lin YS,Chow LP. The protease allergen Pen c 13 induce allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model . J. Biol. Chem. .2011 ;(286):26667-26679

27. 2011 Kuo BJ,Yuan ZF,Lin YS,Lin YN,Li WS,Yang CCH, Lai CJ. Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats . Respir. Physiol. Neurobiol. .2011 ;(175):70-79

28. 2011 Bien MY,Lin YS,Shih CH,Yang LY,Lin HW,Bai KJ, Wang JH, Kou YR. Comparisons of predictive performance of breathing pattern variabilities measured during T-piece, automatic tube compensation and pressure support ventilation for weaning ICU patients from mechanical ventilation . Critical Care Medicine .2011 ;(accept)

29. 2010 Lin YS,Hsu CC,Bien MY,Bien MY,Weng HT,Kou YR. Activations of TRPA1 and P2X receptors are important in the ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats . J. Appl. Physiol .2010 ;(108):1293-1303

30. 2010 Lee LY,Gu Q,Lin YS. Effect of smoking on cough reflex sensitivity: basic and pre-clinical studies . Lung .2010 ;(188):23-27

31. 2010 Lin YS,Hsu CC,Bien MY,Hsu HC,Weng HT,Kou YR. Activations of TRPA1 and P2X receptors are important in the ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats . J Appl Physiol .2010

32. 2009 Lin YS,Lin RL,Bien MY,Ho CY,Kou YR. Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: the role of transient receptor potential vanilloid 1 receptors (in press) . J. Appl. Physiol. .2009 ;(106):1142-1152

33. 2009 Chun-Chun Hsu,Mauo-Ying Bien,Ya Tien Huang,Ting Ruan,Yu Ru Kou,You Shuei Lin. N-Arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents . Respiratory Physiology & Neurobiology .2009 ;(167):323-332

34. 2009 Bien MY,Lin YS,Shie HG,Yang YL,Shih CH,Wang JH, Cheng KC. The Rapid Shallow Breathing Index and Its Predictive Accuracy Measured under Five Different Ventilatory Strategies in the Same Patient Group . The Chinese Journal of Physiology .2009

35. 2009 Lee LY,Gu Q,Lin YS. Effect of Smoking on Cough Reflex Sensitivity: Basic and Pre-clinical Studies . Lung .2009

36. 2009 Bien MY,Jung F,Lin YS,Yang SS. Clinical Application of Extracorporeal Membrane Oxygenation . Journal of Respiratory Therapy .2009

37. 2007 Gu Q,YS Lin,LY Lee. Epinephrine enhances the sensitivity of rat vagal chemosensitive neurons: role of β3-adrenoceptor. . J. Appl. Physiol. .2007 ;(102):1545-1555

38. 2007 Li TL,Chiou LC,Lin YS,Hsieh JR,Hwang LL. Electrophysiological Study on the Effects of Leptin in Rat Dorsal Motor Nucleus of the Vagus. . Am J Physiol Regul Integr Comp Physiol .2007 ;(102):1545-1555

39. 2006 Ruan T,Lin YS,Lin KS,Kou YR. Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats . J Appl Physiology .2006 ;(101):644-654

40. 2005 Ruan T,Lin YS,Lin KS,Kou YR. Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats . J. Physiol. .2005 ;(565):563-578

41. 2005 Lin RL,Gu Q,Lin YS,Lee LY. Stimulatory effect of CO2 on vagal bronchopulmonary C-fiber afferents during airway inflammation . J. Appl. Physiol. .2005 ;(99):1704-1711

42. 2003 Lin Y,Gu Q,Lee LY. Activation of dopamine D2-receptors attenuates hyperresponsiveness of bronchopulmonary C-fibers induced by prostaglandin E2 in rats . Am. J. Respir. Crit. Care Med. .2003 ;(167):1096-1101

43. 2003 Lee LY, Lin YS, Gu Q, Chung E, and Ho CY. Functional morphology and physiological properties of bronchopulmonary C-fiber afferents . Anat. Rec. .2003 ;(270):17-24

44. 2002 Lin YS and Lee LY. Stimulation of pulmonary vagal C-fibres by anandamide in anaesthetized rats: role of vanilloid type 1 receptors. . J. Physiol. (London) .2002 ;(539):947-955

45. 2002 Lee LY, Kwong K, Lin YS, and Gu Q. Hypersensitivity of bronchopulmonary C-fibers induced by airway mucosal inflammation: cellular mechanisms . Pulm. Pharmacol. Ther. .2002 ;(15):199-204

46. 2001 Ho CY, Gu Q, Lin YS, and Lee LY. Sensitivity of vagal afferent endings to chemical irritants in the rat lung . Respir. Physiol. .2001 ;(127):113-124

47. 2001 Lin YS, Ho CY, Tang GJ, and Kou YR. Alleviation of wood smoke-induced lung injury by tachykinin receptor antagonist and hydroxyl radical scavenger in guinea pigs . Eur. J. Pharmacol. .2001 ;(425):141-148

48. 2000 Lin YS, and Kou YR. Acute neurogenic airway plasma exudation and edema induced by inhaled wood smoke in guinea pigs: role of tachykinins and hydroxyl radical . Eur. J. Pharmacol. .2000 ;(394):139-148

49. 2000 Lin YS, Ho CY, Chang SY, and Kou YR. Laryngeal C-fiber afferents are not involved in the apneic response to laryngeal wood smoke in anesthetized rats . Life Sci. .2000 ;(66):1695-1704

50. 1999 Kou YR, Lin YS, Ho CY, and Lin CZ. Neonatal capsaicin treatment alters immediate ventilatory responses to inhaled wood smoke in rats . Respir. Physiol. .1999 ;(116):115-123

51. 1998 Tang GJ, Kou YR, and Lin YS. Peripheral neural modulation of endotoxin induced hyperventilation . Crit. Care Med. .1998 ;(26):1558-1563

52. 1997 Lin YS, and Kou YR. Reflex apneic response evoked by laryngeal exposure to wood smoke in rats: neural and chemical mechanisms. . J. Appl. Physiol. .1997 ;(83):723-730

53. 1997 Kou YR, Lai CJ, Hsu TH, and Lin YS. Involvement of hydroxyl radical in the immediate ventilatory responses to inhaled wood smoke in rats . Respir. Physiol. .1997 ;(107):1-13

會議論文 Conference Paper


1. 2011 Lin YS,Yang W,Lee LY. Effect of 5-hydroxytryptamine (5-HT) on Rat Capsaicin-sensitive Vagal Pulmonary Sensory Neurons via Activation of 5-HT3 Receptors . FASEB J .2011

2. 2010 Bien MY,Kou YR,Lin YS,Shih CH,Lin HW. Analysis of breath-to-breath rapid shallow breathing index variability during T-piece, automatic tube compensation, and pressure support ventilation trials in weaning patients . Journal of Respiratory Therapy .2010

3. 2009 You Shuei Lin,Hsu-Ting Weng,Chun-Chun Hsu,Yu Ru Kou. Role of TRPV1 and P2X receptors in the stimulation of capsaicin-sensitive lung vagal afferent fibers by inhaled cigarette smoke in rats . IUPS .2009

4. 2008 Bien MY,Lin YS,Shih CH,Wang JH,Kou YR. Differences in breathing pattern variabilities measured during T-piece, automatic tube compensation and pressure support ventilation in patients with weaning success and failure . Annual Convention of European Respiratory Society .2008

5. 2006 Huang YT,Shiu SS,Yang CC,Lin YS. Airway Hyperresponsiveness Induced by Lung Exposure to 1,3-beta-D-glucan. Proceeding of the American Thoracic Society. . Proceeding of the American Thoracic Society. .2006

6. 2006 Peng AY,Kuo YL,Lin PY,Lin YS. Pulmonary Responses Evoked by Lung Exposure to 1,3-beta-D-glucan in Anesthetized Rats: Role of Hydroxyl Radicals . Proceeding of the American Thoracic Society. .2006

7. 2005 Lin YS,Lin RL,Chen YL,Lee LY. Hypersensitivity of Pulmonary C-fiber Afferents Induced by Anandamide in Anesthetized Rats: Role of Vanilloid Type 1 Receptors . Proceeding of the American Thoracic Society. .2005

8. 2005 Lin YS,Sung HJ,Lee CC,Lin CM,Chiu YY,Lee YJ, Chen WY, Chen YL, Lin PY. Involvement of Pulmonary Vagal C Fibers in Pulmonary Responses After Lung Exposure to 1,3-beta-D-glucan in Anesthetized Rats. . Proceeding of the American Thoracic Society .2005

9. 2003 Lin YS, Ruan T and Lee LY. Stimulation of pulmonary C-fiber afferents by 5-hydroxytryptamine (5-HT) in anesthetized rats: role of 5-HT3 receptors . Am. J. Respir. Crit. Care Med. .2003

10. 2003 Ruan T, Lin YS, and Lee LY. Effect of 5-hydroxytryptamine (5-HT) on pulmonary mechanoreceptors in anesthetized rats: role of 5-HT3 receptors . Am. J. Respir. Crit. Care Med. .2003

11. 2002 Gu Q, Kwong K, Lin YS, and Lee LY. EP2 and EP4 prostanoid receptors mediate prostaglandin E2-induced hypersensitivity in rat vagal capsaicin-sensitive neurons: in vivo and in vitro studies . FASEB J. .2002 ;(16):A454

12. 2002 Lin YS, and Lee LY. Stimulation of pulmonary vagal C fibers by anandamide in anesthetized rats: role of vanilloid type 1 receptors . Am. J. Respir. Crit. Care Med. .2002 ;(165):A722

13. 2002 Lin YS, Gu Q, and Lee LY. Stimulatory and sensitizing effects of epinephrine on vagal pulmonary C fibers in anesthetized rats. . FASEB J. .2002 ;(16):A454

14. 2001 Lin YS, Gu Q, and Lee LY. Attenuation of ozone-induced tachypnoea by activation of dopamine D2-receptors in the rats: involvement of vagal bronchopulmonary C-fibres . .2001

15. 2001 Lin YS, Gu Q, and Lee LY. Activation of dopamine D2 receptor attenuates hyperresponsiveness of pulmonary C fibers induced by prostaglandin E2 in rats . FASEB J. .2001 ;(15):A797

16. 2000 Lin YS, and Kou YR. Acute neurogenic airway plasma exudation and edema induced by inhaled wood smoke in guinea pigs: role of tachykinins and hydroxyl radical . FASEB J. .2000 ;(14):A604

17. 2000 Lin SH, Lin YS, Jeng MJ, and Kou YR. Importance of respiratory frequency in the overinflation-induced lung injury in guinea pigs . FASEB J. .2000 ;(14):A604

18. 1999 Lin YS, and Kou YR. Superior laryngeal C-fiber afferents are not involved in evoking the reflex apneic response to laryngeal wood in rats . FASEB J. .1999 ;(13):A822

19. 1998 Lin YS, and Kou YR. Chemical factors contributing to the airway plasma exudation induced by inhaled wood smoke in guinea pigs . FASEB J. .1998 ;(12):A174

20. 1996 Kou YR, and Lin YS. Reflex apneic response evoked by laryngeal exposure to wood smoke in rats . FASEB J. .1996 ;(10):A638

研究計畫

計畫名稱
113 貴機構延攬沈彥志君參與「舒馬曲坦誘發呼吸反應之機轉探討 : 肺牽張感覺神經受器的角色」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助(NSTC 113-2811-B-038-047)，補助項目為研究費、年終獎金、離職儲金、保險費等，請查照。
補助單位
國家科學及技術委員會
計畫名稱
113 舒馬曲坦誘發呼吸反應之機轉探討 : 肺牽張感覺神經受器的角色(2/3)
補助單位
國家科學及技術委員會
計畫名稱
112 貴校延攬沈彥志君參與「舒馬曲坦誘發呼吸反應之機轉探討 : 肺牽張感覺神經受器的角色」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助(NSTC 112-2811-B-038-061)，補助項目為研究費、年終獎金、離職儲金、保險費等，請查照。
補助單位
國家科學及技術委員會
計畫名稱
112 舒馬曲坦誘發呼吸反應之機轉探討 : 肺牽張感覺神經受器的角色(1/3)
補助單位
國家科學及技術委員會
計畫名稱
111 2023美國胸腔學會會議(研究生：醫學科學研究所博士班詹乃儒君)
補助單位
國家科學及技術委員會
計畫名稱
110 110年度「補助博士生赴國外研究」(千里馬)-詹乃儒
補助單位
科技部
計畫名稱
110 Metformin抑制TRPA1與P2X3受器所引發的呼吸反射及過度敏感之機制探討
補助單位
科技部
計畫名稱
109 英明格引發呼吸道過度敏感:肺C纖維的角色(3/3)
補助單位
科技部
計畫名稱
108 英明格引發呼吸道過度敏感:肺C纖維的角色(2/3)
補助單位
科技部
計畫名稱
107 英明格引發呼吸道過度敏感:肺C纖維的角色(1/3)
補助單位
科技部
計畫名稱
106 活化腺?酸A3受體對於呼吸道敏感的抑制作用:肺C纖維感覺神經的角色(2/2)
補助單位
科技部
計畫名稱
105 活化腺?酸A3受體對於呼吸道敏感的抑制作用:肺C纖維感覺神經的角色(1/2)
補助單位
科技部
計畫名稱
105 活化腺?酸A3受體對於呼吸道敏感的抑制作用:肺C纖維感覺神經的角色(1/2)
補助單位
計畫名稱
104 活化腺?酸A3受體對於呼吸道敏感的抑制作用
補助單位
科技部
計畫名稱
103 硫化氫引發呼吸道過度敏感機轉之探討
補助單位
科技部
計畫名稱
95 1,3-beta-D-glucan侵入肺部所引發肺迷走C纖維感覺神經過度敏感發炎機轉的探討2-2
補助單位
行政院國家科學委員會
計畫名稱
95 1,3-beta-D-glucan 侵入肺部所引發肺迷走C 纖維感覺神經過度敏感機轉
補助單位
行政院國家科學委員會
計畫名稱
94 1,3-beta-D-glucan侵入肺部所引發氣道過度反應機轉之探討
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
94 1,3-beta-D-glucan侵入肺部所引發肺迷走C纖維感覺神經過度敏感發炎機轉的探討1/2
補助單位
行政院國家科學委員會
計畫名稱
93 Vanilloid 第一型受器的內生性活化物造成肺迷走C纖維感覺神經敏感化之作用機轉
補助單位
行政院國家科學委員會
計畫名稱
92 肺C纖維感覺神經在1,3-beta-D-glucan 引發氣道過度反應中所扮演的角色　　
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
92 Vanilloid第一型受器之內生性活化物造成肺迷走C纖維感覺神經敏感化之作用機轉
補助單位
行政院國家科學委員會
計畫名稱
92 1,3-beta-D-glucan對肺迷走C纖維感覺神經的作用
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
91 Anandamide 對於大白鼠肺化學反射感度的影響
補助單位
臺北醫學大學