阮淑慧(Juan, Shu-Hui) 教授

Email
juansh@tmu.edu.tw
現   職
生理學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
美國猶他州大學生物化學研究所 博士
1994/01/01~1998/12/01
美國猶他州大學食品營養學系 碩士
1991/10/01~1993/12/01
私立臺北醫學院保健營養學系 學士
1986/10/01~1990/06/01

本校學術經歷

任職單位與職稱[起迄時間]
生理學科教授
2009/08/01~
生理學科副教授
2005/08/01~2009/07/31
生理學科助理教授
2003/08/01~2005/07/31
生理學科助理教授
2001/08/01~2003/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學科學研究所副教授
2007/08/01 ~
神經科學研究所副教授
2006/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
國立中興大學農學院食品科學系兼任助理教授
中央研究院生物醫學研究所博士後研究

專長與研究領域

學門領域
Physiology
Cardiovascular disease
Signal transduction
Endothelial and smooth muscle cell physiology
Angiogenesis
Cell migration
學術專長
Recombinant DNA technique
EMSA and CHIP assay
DNA manipulation and cloning
Histologic staining techniques
In situ hybridization
Immunohistochemistry
Primary and cell line culture

論文著作

清冊下載


1. 2023 Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells. . Int J Mol Sci. .2023 ;(24):9738-52

2. 2022 L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. . Sci Rep. .2022 ;(12):4673-4686

3. 2022 Chou CL,Juan SH,Li CH,Chen HH,Kao CC,Chen LY, Chien LN, Fang TC. Association Between DPP-4 Inhibitors and Events of Colorectal and Liver Cancers in Patients With Diabetes Receiving Second-Line Agents: A Nested Case-Control Study. . Front Oncol. .2022

4. 2022 Wang WC,Juan SH,Li CH,Chou CL,Chen LY,Chien LN, Fang TC. Valacyclovir-associated neurotoxicity among patients on hemodialysis and peritoneal dialysis: A nationwide population-based study . Front Med (Lausanne) .2022

5. 2022 Chen CM,Houng JY,Ko TL,Juan SH,Chou HC. Sigesbeckia orientalis Extract Ameliorates the Experimental Diabetic Nephropathy by Downregulating the Inflammatory and Oxidative Stress Signaling Pathways . Evid Based Complement Alternat Med .2022

6. 2021 Wen LL,Chen YT,Lee YC ,Ko TL ,Chou HC,Juan SH. Perfluorooctane sulfonate induces autophagy-associated apoptosis through oxidative stress and the activation of extracellular signal–regulated kinases in renal tubular cells . Plos One .2021 ;(16):1-15

7. 2021 Yang LY,Tsai MY,Juan SH, Chang SF,Yu CR,Lin JC, Johnson KR, Lim HG, Fann YC, Lee YG.. Exerting the Appropriate Application of Methylprednisolone in Acute Spinal Cord Injury Based on Time Course Transcriptomics Analysis. . Int J Mol Sci. 2021 Dec 1;22(23):13024. .2021 ;(22):13024-13038

8. 2020 Wang YC,Juan SH,Chou CL,Hsieh TC,Wu JL,Fang TC. Long-Term Effects of Ketoanalogues on Mortality and Renal Outcomes in Advanced Chronic Kidney Disease Patients Receiving a Low-Protein Diet. . Nutrients .2020 ;(12):2708

9. 2019 Chang CC,Huang KH,Hsu SP,Lee YCG,Sue YM,Juan SH. Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation . Scientific Reports .2019 ;(9):4606-18

10. 2019 Lee YCG,Sue YM,Lee CK ,Huang HM,He JJ, Wang YS, Juan SH. Synergistic effects of cAMP–dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes . Phytomedicine .2019 ;(55):255-263

11. 2018 Hyperglycemia induces epithelial-mesenchymal transition in the lungs of experimental diabetes mellitus. . Acta Histochem .2018 ;(120):525-33

12. 2018 Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys. . J Renin Angiotensin Aldosterone Syst. .2018 ;(19):1-11

13. 2018 MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells. . Pharmacology. .2018 ;(102):262-71

14. 2017 Chou HC,Wen LL,Chang CC,Lin CY,Jin L,Juan SH. L-carnitine via PPARγ- and Sirt1-dependent mechanisms attenuates epithelial-mesenchymal transition and renal fibrosis caused by perfluorooctanesulfonate. . Toxicological Sciences .2017

15. 2017 Teng MS,Hsu LA ,Juan SH ,Lin WC ,Lee MC ,Su CW, Wu S, Ko YL.. A GDF15 3′ UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p . PLoS One .2017 ;(12):e0183187

16. 2017 Chang CC,Hsu YH,Chou HC,Lee YG,Juan SH. 3-Methylcholanthrene/Aryl-Hydrocarbon Receptor-Mediated Hypertension through eNOS Inactivation. . J Cell Physiol. .2017 ;(232):1020-1029

17. 2016 Wen LL,Lin CY,Chou HC,Chang CC,Lo HY,Juan SH. Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation. . Plos One .2016 ;(11(5)):e-015519

18. 2015 Cheng KT,Wang YS,Chou HC,Chang CC,Lee CK,Juan SH. Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes:Roles of AMPK and PPAR α in the lipolytic effect of kinsenoside . Phytomedicine .2015 ;(Accept)

19. 2015 Teng MS,Hsu LA,Wu S,Sun YC,Juan SH,Ko YL.. Association of CDH13 Genotypes/Haplotypes with Circulating Adiponectin Levels, Metabolic Syndrome, and Related Metabolic Phenotypes: The Role of the Suppression Effect. . PLoS One. .2015 ;(10):e01226-64

20. 2014 Chang CC,Sue YM,Yang NJ,Lee YH,Juan SH. 3-Methylcholanthrene, an AhR Agonist, Caused Cell-Cycle Arrest by Histone Deacetylation through a RhoA-Dependent Recruitment of HDAC1 and pRb2 to E2F1 Complex. . PLoS ONE .2014 ;(9):e9279

21. 2014 Hsu YH,Chang CC,Yang NJ,Lee YH,Juan SH. RhoA-Mediated Inhibition of Vascular Endothelial Cell Mobility: Positive Feedback Through Reduced Cytosolic p21 and p27. . J Cell Physiol. Feb 18. .2014

22. 2014 Sue YM,Chou HC,Chang CC,Yang NJ,Chou Y,Juan SH. L-Carnitine Protects against Carboplatin-Mediated Renal Injury: AMPK- and PPARα-Dependent Inactivation of NFAT3. . PLoS One. .2014 ;(9):104079

23. 2013 Wen HC,Kao C,,Hsu RC,Huo YN,Ting PC,Chen LC, Hsu SP, Juan SH, Lee WS.. Thy-1-induced migration inhibition in vascular endothelial cells through reducing the RhoA activity. . PLoS One. 2013 Apr 17 .2013 ;(8(4)):1-10

24. 2013 Chou Y,Lin HC,Chen KC,Chang CC,Lee WS,Juan SH. Molecular Mechanisms Underlying the Antiproliferative and Antimigratory Effects of Folate on Homocysteine-Challenged Rat Aortic Smooth Muscle Cells. . Br J Pharmacol .2013 ;(Feb 20)

25. 2013 Teng MS,Hsu LA,Wu S,Chou HH,Chang CJ,Sun YZ, Juan SH, Ko YL. Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level. . Atherosclerosis. .2013 ;(228):406-12

26. 2012 Chang CC,Lee PS,Chou Y,Huang LL,Juan SH. Mediating Effects of Aryl-Hydrocarbon Receptor and RhoA in Altering Brain Vascular Integrity, and the Therapeutic Potential of Statins . American Journal of Pathology .2012 ;(181):211-21

27. 2011 Sue YM,Cheng CF,Chou Y,Chang CC,Lee PS,Juan SH. Ectopic overexpression of heme oxygenase-1 protects kidneys from carboplatin-mediated apoptosis. . British Journal of Pharmacology .2011 ;(162):1716-30

28. 2011 Peng PH,Chao HM,Juan SH,Chen CF,Liu JH,Ko ML. Pharmacological preconditioning by low dose cobalt protoporphyrin induces heme oxygenase-1 overexpression and alleviates retinal ischemia-reperfusion injury in rats. . Curr Eye Res. .2011 ;(36):238-46

29. 2010 Lee FP,Jen CY,Chang CC,Chou Y,Lin H,Chou CM, Juan SH. Mechanisms of adiponectin-mediated COX-2 induction and protection against iron injury in mouse hepatocytes . Journal of Cellular Physiology .2010 ;(224):837-847

30. 2010 Sun YY,Wang CY,Hsu MF,Juan SH,Chang CY,Chou CM, Yang LY, Hung KS, Xu J, Lee YH, Hsu CY. Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1alpha in a cell-type-specific manner. . J Neurosci. .2010 ;(30):9621-30

31. 2010 Lin H,Yu CH,Jen CY,Cheng CF,Chou Y,Chang CC, Juan SH*. Adiponectin-Mediated Heme Oxygenase-1 Induction Protects Against Iron-Induced Liver Injury via a PPAR{alpha}-Dependent Mechanism. . Am J Pathol. .2010 ;(177):1697-709

32. 2010 Lin H,Sue YM,Chou Y,Cheng CF,Chang CC,Li HF, Chen CC, Juan SH*.. Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis. . Br J Pharmacol. .2010 ;(161):1661-1676

33. 2009 Sue YM,Chung CP,Lin H,Chou Y,Jen CY,Li HF, Chang CC, Juan SH. PPAR{delta}-mediated p21/p27 induction via increased CBP nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells. . Am J Physiol Cell Physiol. .2009 ;(297):C321-9

34. 2009 Chang CC,Tsai SY,Lin H,Li HF,Lee YH,Chou Y, Jen CY, Juan SH. Aryl-hydrocarbon receptor-dependent alteration of FAK/RhoA in the inhibition of HUVEC motility by 3-methylcholanthrene. . Cell Mol Life Sci. 2009 .2009 ;(66):3193-205

35. 2009 Sue YM,Cheng CF,Chang CC,Chau Y,Chen CH,Juan SH. Antioxidation and anti-inflammation by heme oxygenase-1 contributes to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells . Nephrology Dialysis Transplantation. .2009 ;(24):769-77

36. 2008 Cheng CF*,Juan SH*,(*equalcontribution),Chen JJ,Chao YC,Chen HH, Lian WS, Lu CY, Chang CI, Chiu TH, Lin H. Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis. . Apoptosis. 2008 Jul;13(7):883-94. .2008 ;(13):883-94

37. 2008 Hsu SP,Ho PY,Juan SH,Liang YC,Lee WS. Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway . Cell Mol Life Sci. 2008 Oct 14. [Epub ahead of print] .2008

38. 2008 Lin CW,Hou WC,Shen SC,Juan SH,Ko CH,Wang LM, Chen YC. Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. . Carcinogenesis. 2008 Sep;29(9):1807-15. Epub 2008 Jul 14. .2008 ;(29):1807-15

39. 2008 Lin H,Lee JL,Hou HH,Chung CP,Hsu SP,Juan SH. Molecular Mechanisms of the Antiproliferative Effect of Beraprost, a Prostacyclin Agonist, in Murine Vascular Smooth Muscle Cells . Journal of Cellular Physiology J Cell Physiol. .2008 ;(214):434-441

40. 2008 Peng PH,Lin YH,Lee YH,Hou HH,Hsu SP,Juan SH. Molecular Mechanisms of p21 and p27 Induction by 3-Methylcholanthrene, an Aryl-Hydrocarbon Receptor Agonist, Involved in Antiproliferation of Human Umbilical Vascular Endothelial Cells . Journal of Cellular Phyisology. .2008 ;(215):161-71

41. 2008 Lin CH,Juan SH,Wang CY,Sun YY,Chau CM,Chang SF, Hu SY, Lee WS, Lee YH.. Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons. . J Neurochem. 2008 Mar;104(5):1415-29. .2008 ;(104):1415-29

42. 2008 Peng PH,Ko ML,Chen CF,Juan SH,Dec;115(11):335-42.. Heme oxygenase-1 gene transfer protects retinal ganglion cells from ischemia-reperfusion injury. . Clin Sci (Lond). 2008 Mar 14; [Epub ahead of print] .2008 ;(115):335-42

43. 2007 Hsu YF,Lee TS,Lin SY,Hsu SP,Juan SH,Hsu YH, Zhong WB, Lee WS. Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells. . Mol Carcinog. .2007 ;(46):275-83

44. 2007 Juan SH,Chen CH,Hou CC,Chen TH,Lin H,Chu YL, Su YM. Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. . Nephrol Dial Transplant .2007 ;(22):732-9

45. 2006 Lee MH,Jiang CB,Juan SH,Lin RD,Hou WC. Antioxidant and heme oxygenase-1 (HO-1)-induced effects of selected Taiwanese plants. . Fitoterapia. .2006

46. 2006 Juan SH,Lee JL,Ho PY,Lee YH,Lee WS. Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells. . European Journal of Pharmacology .2006 ;(530):1-9

47. 2005 Chao HH,Juan SH,Liu JC,Yang HY,Yang E,Cheng TH, Shyu KG. Resveratrol inhibits angiotensin II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells. . European Journal of Pharmacology .2005 ;(515):1-9

48. 2005 Chao HH,Chen JJ,Chen CH,Lin H,Cheng CF,Lian WS, Chen YL, Juan SH, Liu JC, Liou JY, Chan P. Inhibition of angiotensin II induced endothelin-1 gene expression by 17-beta-oestradiol in rat cardiac fibroblasts. . Heart .2005 ;(91):664-9

49. 2005 Juan SH,Cheng TH,Lin HC,Chu YL,Lee WS. Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. . Biochemical Pharmacology .2005 ;(69):41-48

50. 2005 Huang HM,Liang YC,Cheng TH,Chen CH,Juan SH. Potential Mechanism of Blood Vessels Protection by Resveratrol, a Red Wine Component . Annals of the New York Academy of Sciences .2005 ;(1042):349-56

51. 2005 Juan SH,Yen JY,Lee HM,Huang HM. IL-5 Inhibits Apoptosis by Upregulation of c-myc Expression in Human Hematopoietic Cells . Annals of the New York Academy of Sciences .2005 ;(1042):481-7

52. 2004 Shih CM,Lin H,Liang YC,Lee WS,Bi WF,Juan SH. Concentration-dependent differential effect of quercetin on rat aortic smooth muscle cells . European Journal of Pharmacology .2004 ;(496):41-48

53. 2004 Juan SH,Chen JJ,Chen CH,Lin H,Cheng CF,Liu JC, Hsieh MH, Chen YL, Chao HH, Cheng TH. 17beta-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells. . Am J Physiol Heart Circ Physiol. .2004 ;(287):H1254-61

54. 2004 Lin HC,Cheng TH,Chen YC,Juan SH. Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells . Pharmacology .2004 ;(71):107-112

55. 2004 Hong HJ, Chan P,Chan P,Liu JC,Juan SH,Huang MT,Lin JG, Cheng TH.. Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. . Cardiovasc Res. 2004 Jan 1;61(1):159-68. .2004 ;(61):159-68

56. 2004 Hong HJ,Liu JC,Chan P,Juan SH,Loh SH,Lin JG, Cheng TH.. 17beta-estradiol downregulates angiotensin-II-induced endothelin-1 gene expression in rat aortic smooth muscle cells. . J Biomed Sci. .2004 ;(11):27-36

57. 2003 Hsu, H.-K., Juan, S.-H., Ho, P.-Y., Liang, Y.-C., Lin C.-H., Teng, C.-M & Lee W.-S.. Inhibition of Human Vascular Endothelial Cells Proliferation by YC-1 Through a cyclic GMP-Independent Pathway. . Biochemcal Pharmacology .2003 ;(66):263-271

58. 2003 Lee W.-S., Liu, C.-W., Juan, S.-H., Liang, Y.-C., Ho, P.-Y., &Lee Y.-H.. Molecular mechanism of progesterone-induced antiproliferation in rat aortic smooth muscle cells. . Endocrinology .2003 ;(144):2785-2790

59. 2003 Cheng, C.-M., Hong, H.-J., Liu, J.-C., Shih, N.-L., Juan, S.-H., Loh, S.-H., Chan, P., Chen, J-J., & Cheng, T.-H.. Crucial Role of Extracellular Signal-regulated Kinase Pathway in Reactive Oxygen Species-mediated Endothelin-1 Gene Expression Induced by Endothelin-1 in Rat Cardiac Fibroblasts. . Mol. Phormacol. .2003 ;(63):1002-1011

60. 2003 Lin, H.-Y., Juan, S.-H., Shen, S.-C., Hsu, F.-L., & Chen, Y.-C.. Heme Oxygenase 1 Involves in Flavonoids Inhibition of Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Macrophages. . Biochemcal Pharmacology .2003 ;(66):1821-1832

61. 2001 S.-H. Juan, T.-S Lee, K.-W Tseng, J.-Y. Liou, S.-K Shyue, and L.-Y. Chau. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apoE-deficient mice . Circulation .2001 ;(104):1519-1525

62. 1999 Juan S.-H.,andAust S.D.. Mutational analysis of loading of iron into rat liver ferritin by ceruloplamsin . Arch. Biochem. Biophys. .1999 ;(361):295-301

63. 1998 Juan, S.-H.,andAust, S.D.. Iron and phosphate content of rat liver ferritin heteropolymers . Arch. Biochem. Biophys .1998 ;(357):293-298

64. 1998 Juan, S.-H.,andAust, S.D.. Studies on the interaction between ferritin and ceruloplasmin . Arch. Biochem. Biophys .1998 ;(355):56-62

65. 1998 Guo, J.-H.,Juan, S.-H.,andAust, S.D.. Mutational analysis of the four a-helix bundle iron loading channel of rat liver ferritin . Arch. Biochem. Biophys. 352, 71-77 .1998 ;(352):71-77

66. 1998 Guo, J.-H.,Juan, S.-H.,andAust, S.D.. Suppression of cell growth by heavy chain ferritin . Biochem. Biophys. Res. Commun. 242, 39-45 .1998 ;(242):39-45

67. 1998 Juan, S.-H.,andAust, S.D.. The effect of putative nucleation sites on the loading and stability of iron in ferritin . Arch. Biochem. Biophys .1998 ;(350):259-265

68. 1997 Juan, S.-H., Guo. J.-H., andAust, S.D.. Loading of iron into recombinant rat liver ferritin heteropolymers by ceruloplasmin . Arch. Biochem. Biophys. 341, 280-286 .1997 ;(341):280-286


1. 2005 Juan SH,Ho PY,Lee JL,Lee YH,Lee WS. Antiangiogenic and antiproliferative effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells . The 20th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan P656 .2005

2. 2004 Juan SH,Cheng TH,Liang YC,Lin HC. Differential effects of the increment of quercetin on rat aortic smooth musc . the 68th Annual Scientific Meeting of the Japanese Circulation Society, Tokyo, March 27-29 .2004

3. 2004 Juan SH,Liang YC,Cheng TH. Potential Mechanism of Blood Vessels Protection by Resveratrol, a Red Wine Component . 2nd conference of Asian Society for Mitochondrial Research and Medicine, Taipei 01-02 .2004

4. 2004 Chao HH,Juan SH,Chen CH,Lin H,Liu JC,Cheng TH. Resveratrol down-regulates Angiotensin II-induced endothelin-1 gene expression in rat aortic smooth muscle cells . 2nd Conference of Asian Society for Mitochondrial Research and Medicine .2004

5. 2003 Juan SH, Cheng TH, Chen YC, and Lin HC. Induction of heme oxygenase-1 expression by quercetin in rat aortic smooth muscle cells via p38MAPK and NF-kappaB signaling pathway . XIIIth International Symposium on Atherosclerosis, Oct. 2003, Kyoto, Japan .2003

6. 2000 S.-H. Juan, T.-S Lee, K.-W Tseng, J.-Y. Liou, S.-K Shyue, and L.-Y. Chau. Overexpression of heme oxygenase-1 reduces iron overload in vascular smooth muscle cells in vitro and lesion formation in apoE-deficient mice . .2000

7. 2000 S.-H. Juan,andL.-Y. Chau. Induction of apoptosis in vascular smooth muscle cells by heme oxygenase-1 derived carbon monoxide. . .2000

8. 1998 Juan, S.-H.,andAust, S.D.. Expression and study of recombinant rat liver ferritin heteropolymers . .1998

9. 1997 Guo, J.-H.,Juan, S.-H.,andAust, S.D.. Mutational analysis of the four a-helix bundle iron loading channel of rat liver ferritin . .1997

10. 1997 Juan, S.-H.,andAust, S.D.. The effect of putative nucleation sites on the loading and stability of iron in ferritin . .1997


1. 2002 S.-H. Juan, and L.-Y.. Induction of apoptosis in vascular smooth muscle cells by heme oxygenase-1-derived carbon monoxide. Heme Oxygenase in Biology and Medicine. . Kluwer Academic/Plenum Publishers .2002

研究計畫

計畫名稱
113 貴機構延攬劉志信君參與「辛伐他汀抗透明腎細胞癌的體內相關性,與結合促進代謝藥物的協同作用,經由mevalonate及LKB1/AMPK依賴性途徑」研究計畫案,申請本會補助,業經核定以「博士級研究人員」資格補助(NSTC 113-2811-B-038-028),補助項目為研究費、年終獎金、離職儲金、保險費等,請查照。
補助單位
國家科學及技術委員會

計畫名稱
113 辛伐他汀抗透明腎細胞癌的體內相關性,與結合促進代謝藥物的協同作用,經由mevalonate及LKB1/AMPK依賴性途徑(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 貴機構延攬劉志信君參與「辛伐他汀抗透明腎細胞癌的體內相關性,與結合促進代謝藥物的協同作用,經由mevalonate及LKB1/AMPK依賴性途徑」研究計畫案,申請本會補助,業經核定以「博士級研究人員」資格補助(NSTC 113-2811-B-038-006),補助項目為研究費、離職儲金、保險費等,請查照。
補助單位
國家科學及技術委員會

計畫名稱
112 辛伐他汀抗透明腎細胞癌的體內相關性,與結合促進代謝藥物的協同作用,經由mevalonate及LKB1/AMPK依賴性途徑(1/3)
補助單位
國家科學及技術委員會

計畫名稱
112 貴校延攬印度籍Ashish Rao S君參與「辛伐他汀抗透明腎細胞癌的體內相關性,與結合促進代謝藥物的協同作用,經由mevalonate及LKB1/AMPK依賴性途徑」研究計畫案,申請本會補助,業經核定以「博士級研究人員」資格補助(NSTC 112-2811-B-038-042),補助項目為研究費、年終獎金、離職儲金、機票費、保險費等
補助單位
國家科學及技術委員會

計畫名稱
110 辛伐他汀抗腎細胞癌的作用,經由抑制代謝重編程從mTOR、PPAR到RhoA(3/3)
補助單位
國家科學及技術委員會

計畫名稱
109 辛伐他汀抗腎細胞癌的作用,經由抑制代謝重編程從mTOR、PPAR到RhoA
補助單位
科技部

計畫名稱
109 辛伐他汀抗腎細胞癌的作用,經由抑制代謝重編程從mTOR、PPAR到RhoA(2/3)
補助單位
科技部

計畫名稱
108 辛伐他汀抗腎細胞癌的作用,經由抑制代謝重編程從mTOR、PPAR到RhoA(1/3)
補助單位
科技部

計畫名稱
108 生理學科阮淑慧教授申請補助延攬科技人才印度籍Lateef Reshi 巫瑞旭君參與「辛伐他汀抗腎細胞癌的作用,經由抑制代謝重編程從mTOR、PPAR到RhoA」研究計畫案,業經核定以「博士後研究」資格補助(MOST 108-2811-B-038-521)
補助單位

計畫名稱
107 博士後研究員-李曉芬
補助單位

計畫名稱
107 腎細胞癌機理研究:從RhoA透過微小核酸群調控CD44表現到生物標記及治療之研發(3/3)
補助單位
科技部

計畫名稱
106 腎細胞癌機理研究:從RhoA透過微小核酸群調控CD44表現到生物標記及治療之研發(2/3)
補助單位
科技部

計畫名稱
106 生理學科申請補助延攬科技人才張智程先生參與「腎細胞癌機理研究:從RhoA透過微小核酸群調控CD44表現到生物標記及治療之研發」研究計畫案,業經核定以「博士後研究」補助(MOST 106-2811-B-038-021)
補助單位
科技部

計畫名稱
105 腎細胞癌機理研究:從RhoA透過微小核酸群調控CD44表現到生物標記及治療之研發(1/3)
補助單位
科技部

計畫名稱
105 腎細胞癌機理研究:從RhoA透過微小核酸群調控CD44表現到生物標記及治療之研發(1/3)
補助單位

計畫名稱
105 細胞癌機理研究:從RhoA透過微小核酸群調控CD44表現到生物標記及治療之研發-張智程
補助單位

計畫名稱
104 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色;經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成)的調控與白蘆黎醇/史達汀臨床治療及應用-張智程
補助單位
科技部

計畫名稱
104 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酉每)的調控與白蘆黎醇/史達汀臨床治療及應用(3/3)
補助單位
科技部

計畫名稱
104 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酉每)的調控與白蘆黎醇/史達汀臨床治療及應用(3/3)
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科技部

計畫名稱
103 赴美國波士頓參加EXPERIMENTAL BIOLOGY CONFERENCE,申請補助費用
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科技部

計畫名稱
103 「探討芳香烴受體(AHR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成?)的調控與白蘆黎醇/史達汀臨床治療及應用」
補助單位
科技部

計畫名稱
103 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酉每)的調控與白蘆黎醇/史達汀臨床治療及應用(2/3)
補助單位
行政院國家科學委員會

計畫名稱
102 CD44和RhoA蛋白在腎細胞癌之角色並鑑別miRNAs對CD44的誘導作用之影響
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
102 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酶)的調控與白蘆黎醇/史達汀臨床治療及應用(1/3)
補助單位
行政院國家科學委員會

計畫名稱
102 探討芳香烴受體(AHR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酶)的調控與白蘆黎醇/史達汀臨床治療及應用(1-3)
補助單位
科技部

計畫名稱
102 探討芳香烴受體(AHR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酶)的調控與白蘆黎醇/史達汀臨床治療及應用(2/3)
補助單位
科技部

計畫名稱
102 探討芳香火巠受體(AHR)改變血管內皮細胞功能之新角色:經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酶)的調控與白蘆黎醇/史達汀臨床治療及應用-張智程(博)
補助單位
科技部

計畫名稱
101 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色:經由後轉譯修飾細胞週期蛋白的調控與史達汀臨床治療及應用。
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
101 芳香烴碳水化合物協同劑(3MC)對腦血管完整性及通透性之改變,與使用史達汀衍生物的干預治療作用
補助單位
行政院國家科學委員會

計畫名稱
100 芳香烴碳水化合物協同劑(3MC)降低腦血管內皮細胞增生,經由表觀基因修飾,與使用史達汀衍生物的干預治療作用。
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
100 芳香烴碳水化合物協同劑(3MC)對腦血管完整性及通透性之改變,與使用史達汀衍生物的干預治療作用
補助單位
行政院國家科學委員會

計畫名稱
99 芳香烴碳水化合物協同劑抑制新血管生成,相關於內皮細胞生長、附著、趨附性之分子機轉研究,及白蘆黎醇臨床治療與應用
補助單位
行政院國家科學委員會

計畫名稱
98 探討維生素B9對於P53分子調控的機轉
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衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
98 HO-1保護Carboplatin透過NFAT 3所導致老鼠腎管細胞凋亡
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台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
98 葉酸抗趨化作用及抑制癌化動脈血管生成的分子機轉之探討
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
98 探討卡鉑(carboplatin)透過氧化壓力活化NFAT 3造成老鼠腎管細胞凋亡及N-乙醯半胱胺酸(NAC)的保護機制
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台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
98 芳香烴碳水化合物協同劑抑制新血管生成,相關於內皮細胞生長、附著、趨附性之分子機轉研究,及白蘆黎醇臨床治療與應用
補助單位
行政院國家科學委員會

計畫名稱
96 前列環素經由過氧化物酶體增殖激活受體(PPARδ) 調節CBP之位移以增加p21 和p27蛋白質量,並抑制老鼠主動脈平滑肌細胞增生
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
96 芳香烴碳水化合物協同劑抑制新血管生成,相關於內皮細胞生長、附著、趨附性之分子機轉研究,及白蘆黎醇臨床治療與應用
補助單位
行政院國家科學委員會

計畫名稱
95 川芎萃取物川芎嗪誘發HO-1基因表現及HO-1對抑制全達黴素(gentamicin)所引發腎小管細胞凋亡的之機轉探討。
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台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
95 前列環素降低動脈平滑肌生長之機轉研究,以及此機轉對於治療粥狀動物硬化的可能意義(1-2)
補助單位
行政院國家科學委員會

計畫名稱
95 前列環素降低動脈平滑肌生長之機轉研究,以及此機轉對於治療粥狀動物硬化的可能意義(2-2)
補助單位
行政院國家科學委員會

計畫名稱
95 芳香烴碳水化合物受體 (aryl-hydrocardon receptor) 的受質,抑制人類臍帶血管內皮細胞增生及其誘發p21與p27過度表達的分子機制之探討。
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
94 雌激醇對血管內皮細胞中,循環性應力誘發之內皮素基因表現的分子機轉研究,及白蘆黎醇臨床治療與應用(2/2)
補助單位
行政院國家科學委員會

計畫名稱
93 雌激醇對血管內皮細胞中,循環性應力誘發之內皮素基因表現的分子機轉研究,及白蘆黎醇臨床治療與應用(1/2)
補助單位
行政院國家科學委員會

計畫名稱
93 探討HO-1基因治療對於預防糖尿病及高眼壓併發之大鼠視網膜神經細胞凋零的效果
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
92 肝細胞藉由HO-1排出鐵離子之機轉研究,以及此機轉對於貧血、繼發性鐵離過載治療的可能意義(2/2)
補助單位
行政院國家科學委員會

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92 檞皮酮在心血管疾病的藥理研究;及在主動脈平滑肌細胞中,經由檞皮酮誘發HO-1基因表現之機轉探討
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
91 肝細胞藉由HO-1排出鐵離子之機轉研究,以及此機轉對於貧血、繼發性鐵離過載治療的可能意義(1/2)
補助單位
行政院國家科學委員會

計畫名稱
90 於肝臟實質細胞過度表現HFE及原血紅素氧化酵素第一型之現象及其在於發性鐵過量及血色沉著症之應用
補助單位
臺北醫學大學