簡銘賢(Chien, Ming-Hsien) 教授

Email
d002089002@tmu.edu.tw
現   職
研究發展處 副研發長
癌症轉譯研究中心 副主任
臨床醫學研究所 教授

學經歷

學 歷

畢業學校與學位[修業時間]
台北醫學大學醫學研究所 博士
2000/09~2005/07
台北醫學院生物醫學技術研究所 碩士
1998/09~2000/07
中山醫學院醫技系 學士
1994/09~1998/07

本校學術經歷

任職單位與職稱[起迄時間]
臨床醫學研究所教授
2016/02/01~
臨床醫學研究所副教授
2013/02/01~2016/01/31
臨床醫學研究所助理教授
2010/02/01~2013/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
癌症轉譯研究中心副主任
2022/08/01 ~
研究發展處副研發長
2021/08/01 ~
國際醫學研究博士學位學程教授
2018/02/01 ~
國際醫學研究碩士學位學程教授
2018/02/01 ~
國際醫學研究博士學位學程教授
2016/11/01 ~ 2017/10/31
國際醫學研究碩士學位學程教授
2016/11/01 ~ 2017/10/31

其它經歷

任職單位與職稱[起迄時間]
萬芳醫院醫學研究員
國立臺灣大學毒理學研究所博士後研究員
2005/10/24~2009/10/23

專長與研究領域

學門領域
1.
2.
3.
學術專長

論文著作

清冊下載


1. 2024 Chien MH, Yang YC,Ho KH,Ding YF,Chen LH,Chiu WK, Chen JQ, Tung MC, Hsiao M, Lee WJ.. Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma. . Cell Death Dis. .2024 ;(15):82

2. 2023 Lin YW,Wen YC,Hsiao CH,Lai FR,Yang SF,Yang YC,Ho KH,Hsieh FK,Hsiao M,Lee WJ,Chien MH. Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition . Cells. .2023 ;(12):352

3. 2023 Lee KL,Lai TC,Lee WJ,Chen YC,Ho KH, Hung WY,Yang YC,Chan MH,Hsieh FK,Chung CL,Chang JH,Chien MH. Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer . Cancers .2023 ;(15):3288

4. 2023 Wen YC,Lin CY ,Hsiao CH,Wang SS,Huang HC,Lin YW,Ho KH, Chang LC, Yang SF, Chien MH. Genetic variants of dipeptidyl peptidase IV are linked to the clinicopathologic development of prostate cancer . J Cell Mol Med. .2023 ;(27):2507-2516

5. 2023 Yang YC,Lin YW,Lee WJ,Lai FR,Ho KH,Chu CY,Hua KT,Chen JQ,Tung MC,Hsiao M,Wen YC,Chien MH. The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase . J Biomed Sci. .2023 ;(30):68

6. 2023 Ho KH,Pan KF,Cheng TY,Chien MH,Hua KT. Multiple impacts of Naa10p on cancer progression: Molecular functions and clinical prospects . Biochim Biophys Acta Rev Cancer. .2023 ;(1878)

7. 2023 Wen YC,Lin CY ,Ho KH,Lin YW,Hsiao CH,Wang SS,Chang LC,Yang SF,Chien MH. Functional variants of the chitinase 3-like 1 gene are associated with clinicopathologic outcomes and progression of prostate cancer . J Cell Mol Med. .2023

8. 2022 Pan KF, Yang YC, Lee WJ,Hua KT,Chien MH. Proteoglycan Endocan: A multifaceted therapeutic target in Cancer. . Biochim Biophys Acta Rev Cancer. .2022 ;(1877):188672

9. 2022 Chien MH,Shih PC,Ding YF,Chen LH,Hsieh FK,Tsai MY, Li PY, Lin CW, Yang SF. Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity. . Expert Opin Ther Targets. .2022 ;(26):375-388

10. 2022 Tung MC,Lin YW,Lee WJ,Wen YC,Liu YC,Chen JQ, Hsiao M, Yang YC, Chien MH. Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis. . Cell Death Dis. .2022 ;(13):400

11. 2022 Ding YF,Lin YW,Chiu WK,Lin CW,Yang YC,Chang LC, Chang J, Yang SF, Chien MH. Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma . Aging (Albany NY). .2022 ;(14):4500-4512

12. 2022 Lai TC,Lee YL,Lee WJ,Hung WY,Cheng GZ,Chen JQ, Hsiao M, Chien MH, Chang JH. Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer. . Cancers (Basel). .2022 ;(14):2750

13. 2022 Yuan LT,Yang YC,Lee HL,Shih PC,Chen LH,Tang CH, Chang LC, Wang HL, Yang SF, Chien MH. Genetic Polymorphisms of lncRNA LINC00673 as Predictors of Hepatocellular Carcinoma Progression in an Elderly Population . Int J Mol Sci. .2022 ;(23):12737

14. 2021 Hung WY,Lee WJ,Cheng GZ,Tsai CH,Yang YC,Lai TC, Chen JQ, Chung CL, Chang JH, Chien MH. Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway. . Cell Oncol (Dordr). .2021 ;(44):1087-1103

15. 2021 Ding YF,Wen YC,Chuang CY,Lin CW,Yang YC,Liu YF, Chang WM, Chang LC, Yang SF, Chien MH.. Combined Impacts of Genetic Variants of Long Non-Coding RNA MALAT1 and the Environmental Carcinogen on the Susceptibility to and Progression of Oral Squamous Cell Carcinoma. . Front Oncol. .2021 ;(11):684941-684941

16. 2021 Yuan LT,Lee WJ,Yang YC,Chen BR,Yang CY,Chen MW, Chen JQ, Hsiao M, Chien MH, Hua KT.. Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122. . Cancers (Basel) .2021 ;(13):2376-2376

17. 2021 Yang YC,Chien MH,Lai TC,Tung MC,Jan YH,Chang WM, Jung SM, Chen MH, Yeh CN, Hsiao M.. Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma. . J Biomed Sci. .2021 ;(28):29-29

18. 2021 Lee KL,Lai TC,Wang YC,Shih PC,Yang YC,Tsao TC, Liu TC, Wen YC, Chang LC, Yang SF, Chien MH.. Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan. . Genes (Basel) .2021 ;(12):427-427

19. 2021 Pan KF,Lee WJ,Chou CC,Yang YC,Chang YC,Chien MH, Hsiao M, Hua KT.. Direct interaction of β-catenin with nuclear ESM1 supports stemness of metastatic prostate cancer. . EMBO J. .2021 ;(40):e105450-e105450

20. 2020 Chien MH,Yang WE,Yang YC,Ku CC,Lee WJ,Tsai MY, Lin CW, Yang SF. Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells. . Cancers (Basel). .2020 ;(12):E703-E703

21. 2020 Wen YC,Lin YW,Chu CY,Yang YC,Yang SF,Liu YF, Hsiao M, Lee WJ, Chien MH. Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma. . J Pineal Res. .2020 ;(69):e12668-e12668

22. 2020 Hsiao PC,Chang JH,Lee WJ,Ku CC,Tsai MY,Yang SF, Chien MH. The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells. . Cancers (Basel). .2020 ;(12):E2163-E2163

23. 2020 Yang YC,Pan KF,Lee WJ,Chang JH,Tan P,Gu CC, Chang WM, Yang SF, Hsiao M, Hua KT, Chien MH. Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer. . Cancer Res. .2020 ;(80):3292-3304

24. 2020 Lin YW,Wen YC,Chu CY,Tung MC,Yang YC,Hua KT, Pan KF, Hsiao M, Lee WJ, Chien MH. Stabilization of ADAM9 by N-α-acetyltransferase 10 protein contributes to promoting progression of androgen-independent prostate cancer. . Cell Death Dis. .2020 ;(11):591

25. 2020 Yang YC,Chien MH,Lai TC,Su CY,Jan YH,Hsiao M, Chen CL. Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures. . Int J Mol Sci. .2020 ;(21):E2813

26. 2020 Chang JH,Lai TC,Yang PJ,Shih PC,Yang YC,Lee KL, Liu TC, Tsao TC, Yang SF, Chien MH. Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients . Int J Mol Sci. .2020 ;(21):E8023

27. 2019 Wu SY,Wen YC,Ku CC,Yang YC,Chow JM,Yang SF, Lee WJ, Chien MH. Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses. . J Biomed Sci. .2019 ;(26):1-13

28. 2019 Yuan LT,Chang JH,Lee HL,Yang YC,Su SC,Lin CL, Yang SF, Chien MH. Genetic Variants of lncRNA MALAT1 Exert Diverse Impacts on the Risk and Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma. . J Clin Med .2019 ;(8):1-15

29. 2019 Hung WY,Chang JH,Cheng Y,Cheng GZ,Huang HC,Hsiao M, Chung CL, Lee WJ, Chien MH. Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response. . Cell Death Dis .2019 ;(10):1-17

30. 2019 Wu YL,Chien MH,Chou YE,Chang JH,Liu TC,Tsao TC, Chou MC, Yang SF. Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients. . J Cancer. .2019 ;(10):2907-2914

31. 2019 Chien MH,Lin YW,Wen YC,Yang YC,Hsiao M,Chang JL, Huang HC, Lee WJ. Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis . J Exp Clin Cancer Res .2019 ;(38):1-17

32. 2019 Tung MC,Wen YC,Wang SS,Lin YW,Chow JM,Yang SF, Chien MH. Impact of Long Non-Coding RNA HOTAIR Genetic Variants on the Susceptibility and Clinicopathologic Characteristics of Patients with Urothelial Cell Carcinoma . J Clin Med. .2019 ;(8):1-17

33. 2019 Hsiao CH,Ji AT,Chang CC,Chien MH,Lee LM,Ho JH. Mesenchymal stem cells restore the sperm motility from testicular torsion-detorsion injury by regulation of glucose metabolism in sperm . Stem Cell Res Ther .2019 ;(10):1-10

34. 2019 Su CW,Chang YC,Chien MH,Hsieh YH,Chen MK,Lin CW, Yang SF. Loss of TIMP3 by promoter methylation of Sp1 binding site promotes oral cancer metastasis. . Cell Death Dis. .2019 ;(10):1-17

35. 2018 Wang SC,Chow JM,Chien MH, Lin CW, Chen HY,Hsiao PC, Yang SF. Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway. . Environ Toxicol. .2018 ;(33):514-522

36. 2018 Yang YC,Chien MH,Liu HY,Chang YC,Chen CK,Lee WJ, Kuo TC, Hsiao M, Hua KT, Cheng TY. Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress . Cancer Letters .2018 ;(421):28-40

37. 2018 Chien MH,Ho YC,Yang SF,Yang YC,Lai SY,Chen WS, Chen MJ, Yeh CB.. Niclosamide, an oral antihelmintic drug, exhibits antimetastatic activity in hepatocellular carcinoma cells through downregulating twist-mediated CD10 expression . Environmental Toxicology .2018 ;(33):659-669

38. 2018 Weng MS ,Chang JH,Hung WY,Yang YC,Chien MH. The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance . Journal of Experimental and Clinical Cancer Research .2018 ;(37):61

39. 2018 Wang SW,Chen YR,Chow JM,Chien MH ,Yang SF,Wen YC, Lee WJ, Tseng TH. Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells . Molecular Carcinogenesis .2018 ;(57):866-877

40. 2018 Lu KH,Su SC,Lin CW,Hsieh YH,Lin YC,Chien MH, Reiter RJ, Yang SF. Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway . J Pineal Res. .2018 ;(65):e12507-e12507

41. 2018 Su CW,Chien MH,Lin CW,Chen MK,Chow JM,Chuang CY, Chou CH, Liu YC, Yang SF. Associations of genetic variations of the endothelial nitric oxide synthase gene and environmental carcinogens with oral cancer susceptibility and development . Nitric Oxide .2018 ;(79):1-7

42. 2018 Chien MH,Lee WJ,Yang YC,Tan P,Pan KF,Liu YC, Tsai HC, Hsu CH, Wen YC, Hsiao M, Hua KT. N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas . Cancer Lett. .2018 ;(433):86-98

43. 2018 Tung MC,Wen YC,Wang SS,Lin YW,Liu YC,Yang SF, Chien MH. Dopamine receptor D2 genetic variations is associated with the risk and clinicopathological variables of urothelial cell carcinoma in a Taiwanese population. . Int J Med Sci. .2018 ;(15):1187-1193

44. 2018 Chang JH,Cheng CW,Yang YC,Chen WS,Hung WY,Chow JM, Chen PS, Hsiao M, Lee WJ, Chien MH. Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses . J Exp Clin Cancer Res. .2018 ;(37):199-199

45. 2018 Shih YW,Yang SF,Chien MH,Chang CW,Chang VHS,Tsai HT. Significant Effect of Acupressure in Elevating Blood Stem Cell Factor During Chemotherapy in Patients With Gynecologic Cancer . J Nurs Res. .2018 ;(26):411-419

46. 2018 Hung WY,Chang JH,Cheng Y,Cheng CK,Chen JQ,Hua KT, Cheng CW, Hsiao M, Chung CL, Lee WJ, Chien MH. Leukocyte cell-derived chemotaxin 2 retards non-small cell lung cancer progression through antagonizing MET and EGFR activities . Cellular Physiology and Biochemistry .2018 ;(51):337-355

47. 2017 Chien MH,Lee WJ,Yang YC,Li YL,Chen BR,Cheng TY, Yang PW, Wang MY, Jan YH, Lin YK, Lee JM, Hsiao M, Chen JS, Hua KT. KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer . Biochimica et Biophysica Acta - Gene Regulatory Mechanisms .2017 ;(1860):1013-1024

48. 2017 Chen MW,Yang ST,Chien MH,Hua KT,Wu CJ,Hsiao SM, Lin H, Hsiao M, Su JL, Wei LH. The STAT3-miRNA-92-Wnt signaling pathway regulates spheroid formation and malignant progression in ovarian cancer . Cancer Research .2017 ;(77):1955-1967

49. 2017 Chang JL,Chow JM,Chang JH,Wen YC,Lin YW,Yang SF, Lee WJ, Chien MH. Quercetin simultaneously induces G0/G1-phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells . Environmental Toxicology .2017 ;(32):1857-1868

50. 2017 Chien MH,Chang WM,Lee WJ,Chang YC,Lai TC,Chan DV, Sharma R, Lin YF, Hsiao M. A Fas Ligand (FasL)-fused humanized antibody against tumor-Associated glycoprotein 72 selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio . Molecular Cancer Therapeutics .2017 ;(16):1102-1113

51. 2017 Chang JH,Lai SL,Chen WS ,Hung WY,Chow JM,Hsiao M, Lee WJ, Chien MH. Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways . Biochimica et Biophysica Acta - Molecular Cell Research .2017 ;(1864):1746-1758

52. 2017 Hua KT,Liu YF,Hsu CL,Cheng TY,Yang CY,Chang JS, Lee WJ, Hsiao M, Juan HF, Chien MH. 3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma . Scientific Reports .2017 ;(7)

53. 2017 Chien MH,Chow JM,Lee WJ,Chen HY,Tan P,Wen YC, Lin YW, Hsiao PC, Yang SF. Tricetin induces apoptosis of human leukemic HL-60 cells through a reactive oxygen species-mediated c-jun N-terminal kinase activation pathway . International Journal of Molecular Sciences .2017 ;(18):E1667

54. 2017 Chien MH,Lee TH,Lee WJ,Yeh YH,Li TK,Wang PC, Chen JJ, Chow JM, Lin YW, Hsiao M, Wang SW, Hua KT. Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts . Cancer Letters .2017 ;(388):249-261

55. 2017 Lin YW,Wang SS,Wen YC,Tung MC,Lee LM, Yang SF, Chien MH. Genetic variations of melatonin receptor type 1a are associated with the clinicopathologic development of urothelial cell carcinoma . International Journal of Medical Sciences .2017 ;(14):1130-1135

56. 2017 Yang JS,Lin CW ,Hsieh YH,Chien MH ,Chuang CY,Yang SF. Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells . Oncotarget .2017 ;(8):83088-83099

57. 2017 Yeh CM,Su SC,Lin CW,Yang WE,Chien MH,Reiter RJ, Yang SF. Melatonin as a potential inhibitory agent in head and neck cancer . Oncotarget .2017 ;(8):90545-90556

58. 2017 Shih YW,Yang SF,Chien MH,Chang CW, Chang VHS,Tsai HT. Significant Effect of Acupressure in Elevating Blood Stem Cell Factor During Chemotherapy in Patients With Gynecologic Cancer. . J Nurs Res. .2017

59. 2016 Chang PY,Tsao SM,Chang JH,Chien MH ,Hung WY, Huang YW, Yang SF. Plasma levels of soluble intercellular adhesion molecule-1 as a biomarker for disease severity of patients with community-acquired pneumonia . Clinica Chimica Acta .2016 ;(463):174-180

60. 2016 Lin YW,Lee LM,Lee WJ,Chu CY,Tan P,Yang YC, Chen WY, Yang SF, Hsiao M, Chien MH. Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity. . J Pineal Res. .2016 ;(60):277-290

61. 2016 Kao SJ,Lee WJ,Chang JH,Chow JM,Chung CL,Hung WY, Chien MH. Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer. . Environ Toxicol. .2016 ;(0):1-13

62. 2016 Chen WY,Hua KT,Lee WJ,Lin YW,Liu YN,Chen CL, Wen YC, Chien MH. Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy . Int J Mol Sci. .2016 ;(17):E1194-E1194

63. 2016 Lin CW,Yang WE,Lee WJ,Hua KT,Hsieh FK,Hsiao M, Chen CC, Chow JM, Chen MK, Yang SF, Chien MH. Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis. . Carcinogenesis .2016 ;(37):712-722

64. 2016 Tseng TH,Chien MH,Lin WL,Wen YC,Chow JM,Chen CK, Kuo TC, Lee WJ. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression. . Environ Toxicol. .2016 ;(0):1-11

65. 2016 Yong KK,Chang JH,Chien MH,Tsao SM,Yu MC,Bai KJ, Tsao TC, Yang SF. Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia. . Int J Mol Sci. .2016 ;(17):E179-E179

66. 2016 Chang JH,Hung WY,Bai KJ,Yang SF,Chien MH. Utility of Plasma Osteopontin Levels in Management of Community-Acquired Pneumonia . Int J Med Sci .2016 ;(13):673-9

67. 2016 Kuo TC,Chen CK,Hua KT,Yu P,Lee WJ,Chen MW,Jeng YM,Chien MH, Kuo KT, Hsiao M, Kuo ML. Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells . Cancer Lett. .2016 ;(383):282-294

68. 2016 Ho HY,Lin CW,Chien MH,Reiter RJ,Su SC,Hsieh YH, Yang SF. Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma. . J Pineal Res. .2016 ;(61):479-492

69. 2015 Lee WJ,Hsiao M,Chang JL,Yang SF,Tseng TH,Cheng CW, Chow JM, Lin KH, Lin YW, Liu CC, Lee LM, Chien MH. Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft . Archives of Toxicology .2015 ;(89):1103-1117

70. 2015 Yang SF,Lee WJ,Tan P,Tang CH,Hsiao M,Hsieh FK, Chien MH. Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas . Oncotarget .2015 ;(6):2736-2753

71. 2015 Huang HL,Chiang WL,Hsiao PC,Chien MH,Chen HY,Weng WC, Hsieh MJ, Yang SF. Timosaponin AIII mediates caspase activation and induces apoptosis through JNK1/2 pathway in human promyelocytic leukemia cells . Tumour Biol .2015 ;(35):3489-3497

72. 2015 Su S,Chien M,Lin C,Chen M,Yang S. RAGE Gene Polymorphism and Environmental Factor in the Risk of Oral Cancer . J Dent Res .2015 ;(94):403-411

73. 2015 Hsiao SM,Chen MW,Chen CA,Chien MH,Hua KT,Hsiao M, Kuo ML, Wei LH. The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer . Ann Surg Oncol .2015

74. 2015 Lee wj,Chien mh,Chow JM,Chang JL,Wen YC,Lin YW, Cheng CC, Lai GM, Hsiao M, Lee LM. Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress . Scientific Reports .2015 ;(5):10420-10420

75. 2015 Lin FY,Lin CW,Yang SF,Lee WJ,Lin YW,Lee LM, Chang JL, Weng WC, Lin CH, Chien MH*. Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. . PLoS ONE .2015 ;(10):e01216-e01216

76. 2015 Chien MH,Lee WJ,Hsieh FK,Li CF,Cheng TY,Wang MY, Chen JS, Chow JM, Jan YH, Hsiao M, Hua KT, Kuo ML. Keap1-Nrf2 interaction suppresses cell motility in lung adenocarcinomas by targeting the S100P protein. . Clin Cancer Res. .2015 ;(21):4719-4732

77. 2015 Wen YC,Lee WJ,Tan P,Yang SF,Hsiao M,Lee LM, Chien MH*. By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer. . Oncotarget .2015 ;(6):21120-21136

78. 2015 Chao R,Chow JM,Hsieh YH,Chen CK,Lee WJ,Hsieh FK, Yu NY, Chou MC, Cheng CW, Yang SF, Chien MH*. Tricetin suppresses the migration/invasion of human glioblastoma multiforme cells by inhibiting matrix metalloproteinase-2 through modulation of the expression and transcriptional activity of specificity protein 1. . Expert Opin Ther Targets. .2015 ;(19):1293-306

79. 2014 Hsiao PC,Chou YE,Tan P,Lee WJ,Yang SF,Chow JM, Chen HY, Lin CH, LeeLM, Chien MH. Pterostilbene simultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines. . PLoS ONE .2014 ;(9):e10534-e10534

80. 2014 Hsiao PC,Lee WJ,Yang SF,Tan P,Chen HY,Lee LM, Chang JL, Lai GM, Chow JM, Chien MH. Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. . Tumor Biology .2014

81. 2014 Lien GS,Liu JF,Chien MH,Hsu WT,Chang TH,Ku CC, Ji AT, Tan P, Hsieh TL, Lee LM, Ho JH. The ability to suppress macrophage-mediated inflammation in orbital fat stem cells is controlled by miR-671-5p. . Stem Cell Res Ther. .2014 ;(5):97-97

82. 2014 Yu SY,Liao CH,Chien MH,Tsai TY,Lin JK,Weng MS. Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer. . J Agric Food Chem. .2014 ;(62):2085-2095

83. 2014 Huang HL,Hsieh MJ,Chien MH,Chen HY,Yang SF,Hsiao PC. Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. . PLoS One .2014 ;(9):e98943-e98943

84. 2014 Kao SJ,Chuang CY,Tang CH,Lin CH,Bien MY,Yu MC, Bai KJ, Yang SF*, Chien MH*. Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia . Clin Chem Lab Med .2014 ;(52):445-451

85. 2014 Hsieh MC,Hsu HT,Hsiao PC,Yang SF,Yeh CB,Bien MY, Lin CH, Chien MH*. Role of VEGF-C Gene Polymorphisms in Susceptibility to Hepatocellular Carcinoma and Its Pathological Development . J Clin Lab Anal .2014 ;(28):237-244

86. 2014 Hua KT,Lee WJ,Chen CK,Hsiao M,Ku CC,Wei LH, Kuo ML, Chien MH*. Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2 . Biochim Biophys Acta-MCR .2014 ;(1843):387-397

87. 2014 Tung MC,Hsieh MJ,Wang SS,Yang SF,Chen SS,Wang SW, Lee LM, Lee WJ, Chien MH. Associations of VEGF-C Genetic Polymorphisms with Urothelial Cell Carcinoma Susceptibility Differ between Smokers and Non-Smokers in Taiwan. . PLOS ONE .2014 ;(9):e91147-e91147

88. 2014 Wu CH,Ko JL,Chen SC,Lin YW,Han CP,Yang TY, Chien MH, Wang PH. Clinical implications of aldo-keto reductase family 1 member C3 and its relationship with lipocalin 2 in cancer of the uterine cervix . Gynecologic Oncology .2014 ;(132):474-82

89. 2014 Wen YC,Chen WY,Lee WJ,Yang SF,Lee LM,Chien MH. Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy . Clinica Chimica Acta .2014 ;(431):169-73

90. 2014 Yang JS,Chen MK,Yang SF,Chang YC,Su SC,Chiou HL, Chien MH, Lin CW. Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma (in press) . Clinical Chemistry and Laboratory Medicine .2014 ;(52):1367-1377

91. 2013 Yu YH,Chen HA,Chen PS,Cheng YJ,Hsu WH,ChangYW,Chen YH,Jan Y,Hsiao M,Chang TY,Liu YH,Jeng YM,Wu CH,Huang MT,Su YH,Hung MC,Chien MH,Chen CY,. MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol . Oncogene .2013 ;(32):431-443

92. 2013 Wong RH,Huang CH,Yeh CB,Lee HS,Chien MH,Yang SF. Effects of Metallothionein-1 Genetic Polymorphism and Cigarette Smoking on the Development of Hepatocellular Carcinoma. . Ann Surg Oncol .2013 ;(20):2088-2095

93. 2013 Kao SJ,Yang HW,Tsao SM,Cheng CW,Bien MY,Yu MC, Bai KJ, Yang SF, Chien MH. Plasma long pentraxin 3 (PTX3) concentration is a novel marker of disease activity in patients with community-acquired pneumonia. . Clin Chem Lab Med. .2013 ;(51):907-913

94. 2013 Lin CH,Yu MC,Chiang CC,Bien MY,Chien MH,Chen BC. Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells . Cell Signal .2013 ;(25):1166-1175

95. 2013 Cheng CW,Chien MH,Su SC,Yang SF. New markers in pneumonia . Clin Chim Acta .2013 ;(419):19-25

96. 2013 Cheng CW,Su JL,Lin CW,Su CW,Shih CH,Yang SF*, Chien MH*. Effects of NFKB1 and NFKBIA Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathological Features . PLoS ONE .2013 ;(8):e56130-e56130

97. 2013 Chien MH,Liu YF,Hsin CH,Lin CH,Shih CH,Yang SF, Cheng CW, Lin CW. Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan . PLoS ONE .2013 ;(8):e60283-e60283

98. 2013 Yeh YH,Chang JL,Hsiao PC,Tsao SM,Lin CH,Kao SJ, Chou MC, Yang SF*, Chien MH*. Circulating level of lipocalin 2 as a predictor of severity in patients with community-acquired pneumonia . J Clin Lab Anal .2013 ;(27):253-260

99. 2013 Chien MH,Lee LM,Hsiao M,Wei LH,Chen CH,Lai TC, Hua KT, Chen MW, Sun CM, Kuo ML. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs . Evid Based Complement Alternat Med .2013 ;(2013):718380-718380

100. 2013 Lin CH,Yu MC,Tung WH,Chen TT,Yu CC,Weng CM, Tsai YJ, Bai KJ, Hong CY, Chien MH, Chen BC. Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway . Biochim Biophys Acta-MCR .2013 ;(1833):2823-2833

101. 2013 Lin CW,Chuang CY,Tang CH,Chang JL,Lee LM,Lee WJ, Chow JM, Yang SF*, Chien MH*. Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development . PLoS ONE .2013 ;(8):e72940-e72940

102. 2013 Hsiao PC,Hsieh YH,Chow JM,Yang SF,Hsiao M,Hsiao M, Hua KT, Lin CH, Chen HY, Chien MH*. Hispolon Induces Apoptosis through JNK1/2-Mediated Activation of a Caspase-8, -9, and -3-Dependent Pathway in Acute Myeloid Leukemia (AML) Cells and Inhibits AML Xenograft Tumor Growth in Vivo . J Agric Food Chem .2013 ;(61):10063-10073

103. 2012 Chien MH,Lin CW,Cheng CW,Wen YC,Yang SF. Matrix metalloproteinase (MMP)-2 as a target for head and neck cancer therapy. . Expert Opin Ther Tar .2012

104. 2012 Chien MH,Yang JS,Chu YH,Lin CH,Wei LH,Yang SF, Lin CW. Impacts of CA9 gene polymorphisms and environmental factors on oral-cancer susceptibility and clinicopathologic characteristics in Taiwan . PLoS ONE .2012 ;(7):e51051

105. 2012 Chu YH,Tzeng SL,Lin CW,Chien MH,Chen MK,Yang SF. Impacts of MicroRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer . PLoS ONE .2012 ;(7):e39777-e39777

106. 2012 Lin CW,Hsieh YS,Hsin CH,Su CW,Lin CH,Wei LH, Yang SF, Chien MH. Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer . PLoS One .2012 ;(7):e35078-e35078

107. 2012 Kao SJ,Su JL,Chen CK,Yu MC,Bai KJ,Chang JH, Bien MY, Yang SF, Chien MH. Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression . Toxicol Appl Pharmacol .2012 ;(261):105-115

108. 2012 Chien MH,Ying TH,Hsieh YS,Chang YC,Yeh CM,Ko JL, Lee WS, Chang JH, Yang SF. Dioscorea nipponica Makino inhibits migration and invasion of human oral cance rHSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity . Food and Chemical Toxicology .2012 ;(50):558-566

109. 2012 Lin CW,Tseng SW,Yang SF,Ko CP,Lin CH,Wei LH, Chien MH, Hsieh YS. Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer. . Oral Dis .2012 ;(18):734-740

110. 2012 Chung TT,Yeh CB,Li YC,Su SC,Chien MH,Yang SF, Hsieh YH. Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features . PLoS One .2012 ;(7):e33517-e33517

111. 2012 Yeh CB,Hsieh MJ,Hsieh YH,Chien MH,Chiou HL,Yang SF. Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity. . PLoS One .2012 ;(7):e31055-e31055

112. 2012 Chien MH,Ying TH,Yang SF,Yu JK,Hsu CW,Hsieh SC, Hsieh YH. Lipocalin-2 Induces Apoptosis in Human Hepatocellular Carcinoma Cells through Activation of Mitochondria Pathways. . Cell Biochem Biophys .2012 ;(64):177-186

113. 2012 Liu CM,Lin YM,Yeh KT,Chang JH,Chen CJ,Chou MY, Yang SF, Chien MH. Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray . J Oral Pathol Med .2012 ;(41):533-539

114. 2012 Chien MH,Hsin CH,Chou Lin SS,Chung TT,Lin CH,Weng MS, Chou MY, Chen MK, Yang SF. Interleukin (IL)-23 receptor polymorphism is a risk factor for oral cancer susceptibility. . Head & Neck .2012 ;(34):551-556

115. 2012 Chien MH,Bien MY,Ku CC,Chang YC,Pao HY,Yang YL, Hsiao M, Chen CL, Ho JH. Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury . Critical Care Medicine .2012 ;(40):1245-1253

116. 2012 Chien MH,Ying TH,Hsieh YH,Lin CH,Shih CH,Wei LH, Yang SF. Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis . Oral Oncology .2012 ;(48):417-423

117. 2012 Chien MH,Lin SS,Chung TT,Lin CH,Chou MY,Weng MS, Chen MK, Yang SF. Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of oral cancer. . Head & Neck .2012 ;(34):405-411

118. 2011 Chanda K,Maiti B,Yellol GS,Chien MH,Kuo ML,Sun CM. Polymer supported synthesis of novel benzoxazole linked benzimidazoles under microwave conditions: In vitro evaluation of VEGFR-3 kinase inhibition activity. . Org Biomol Chem. .2011 ;(21):1917-1926

119. 2011 Hua KT,Tan CT,Johansson G,Lee JM,Yang PW,Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ,Chen MW, Chien MH, Chen PS,Lee WJ,Ch. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. . Cancer Cell .2011 ;(19):218-231

120. 2011 Chiang TY,Shyu LY,Yao Tsao,Chien MH,Tsao SM,Lee YT, Yang SF. Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia . Clinical Chemistry and Laboratory Medicine .2011

121. 2011 Liu CM,Yeh CJ,Yu CC,Chou MY,Lin CH,Wei LH, Lin CW, Yang SF, Chien MH. Impact of interleukin-8 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan . Oral Diseases .2011

122. 2011 Chien MH,Yeh KT,LI YC,Hsieh YH,Lin CH,Weng MS, Kuo WH, and Yang SF. Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma . Journal of surgical oncology .2011

123. 2011 Chien MH,Lee TS,Kao C,Yang SF,Lee WS. Terbinafine inhibits oral squamous cell carcinoma growth through anti-cancer cell proliferation and anti-angiogenesis . Molecular Carcinogenesis .2011

124. 2011 Chien MH,Yeh CB,Li YC,Wei LH,Chang JH,Peng YT, Yang SF, Kuo WH. Relationship of Interleukin-8 Gene Polymorphisms With Hepatocellular Carcinoma Susceptibility and Pathological Development . Journal of Surgical Oncology .2011 ;(104):798-803

125. 2010 Tzeng JI,Chen BC,Chang HM,Wang JJ,Sureshbabu M,Chien MH, Hsu MJ, Bien MY, Chiu WT, Hong CY, Lin CH. Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages. . Pharmacological Res. .2010 ;(61):162-166

126. 2010 Weng CJ,Chien MH,Lin CW,Chung TT,Zavras AI,Tsai CM, Chen MK, Yang SF. Effect of CC chemokine ligand 5 and CC chemokine receptor 5 genes polymorphisms on the risk and clinicopathological development of oral cancer. . oral oncology .2010

127. 2010 Chien MH,Lee TS,Liang YC,Lee WS. beta-Sitosterol Inhibits Cell Cycle Progression of Rat Aortic Smooth Muscle Cells through Increases of p21(cip1) Protein . J. Agric. Food Chem. .2010 ;(58):10064-10069

128. 2010 Chien MH,Kuo ML,Wei LH. Re: Cyclooxygenase-2, prostaglandin E2 and acute myeloid leukemia . carcinogenesis .2010 ;(31):954-954

129. 2010 Chen MW,Hua KT,Kao HJ,Chi CC,Wei LH,Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huan. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM . Cancer Res. .2010 ;(70):7830-7840

130. 2010 Su JL,Chiou J,Tang CH,Zhao M,Tsai CH,Chen PS, Chang YW,Chien MH, Peng CY, Hsiao M, Kuo ML, Yen ML. CYR61 regulates BMP-2-dependent osteoblast differentiation through the{alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. . J Biol Chem. .2010 ;(285):31325-31336

131. 2009 Chang MS,Chen BC,Weng CM,Lee WS,Lin CH. Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. . Pharmacological Res. .2009 ;(60):247-253

132. 2009 Chen CH,Chien MH,Kuo ML,Chou CT,Lai JJ,Lin SF, Thummanagoti S, Sun CM. Diversity-Oriented Synthesis of Angular Bis-benzimidazole Derivatives under Microwave Irradiation. . J. Comb. Chem. .2009 ;(11):1038-1046

133. 2009 Chien MH,Ku CC,Johansson G,Chen MW,Hsiao M,Su JL, Inoue H, Hua KT, Wei LH, Kuo ML. Vascular endothelial growth factor-c (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. . Carcinogenesis .2009 ;(30):2005-2013

134. 2008 Su JL,Chen PS,Chien MH,Chen PB,Chen YH,Lai CC, Hung MC, Kuo ML. Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells. . Cancer Cell .2008 ;(3):557-560

135. 2006 Chang YC,Li PC,Chen BC,Chang MS,Wang JL,Chiu WT, Lin CH. Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways. . Cell Signal. .2006 ;(18):1235-1243

136. 2005 Chang MS,Chen BC,Yu MT,Sheu JR,Chen TF,Lin CH. Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kB, but not p38 MAPK, pathways. . Cell Signal. .2005 ;(17):299-310

137. 2005 Kao SJ,Lei HC,Kuo CT,Chang MS,Chen BC,Chang YC, Chiu WT, Lin CH. Lipoteichoic Acid induces nuclear factor-kB activation and nitric oxide synthase expression via phosphatidylinositiol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages. . Immunology .2005 ;(115):366-374

138. 2004 Chang MS,Lee WS,Chen BC,Sheu JR,Lin CH. YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, Akt, and NF-kB in human pulmonary epithelial cells. . Mol. Pharmacol. .2004 ;(66):561-571

139. 2004 Chen BC,Yu CC,Lei HC,Chang MS,Hsu MJ,Huang CL, Sheu JR, Chen TF, Chen TL, Lin CH. Bradykinin B2 receptor mediates NF-kB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells. . J. Immunol. .2004 ;(173):5216-5228

140. 2002 Chang MS,Lee WS,Teng CM,Lee HM,Sheu JR,Hsiao G, Lin CH. YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells. . Br. J. Pharmacol. .2002 ;(136):558-567

141. 2002 Lin CH,Chang CW,Wang CC,Chang MS,Yang LL. Byakangelicol, isolated from Angelica dahurica, inhibits both the activity and induction of cyclooxygenase-2 in human pulmonary epithelial cells. . J. Pharm. Pharmacol. .2002 ;(54):1271-1278

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新光醫療財團法人新光吳火獅紀念醫院

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101 中草藥蛇床子素對男性賀爾蒙依賴型前列腺癌細胞侵襲轉移能力之影響及其相關分子機制探討
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臺北醫學大學

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100 研究C 型血管內皮生長因子在急性骨髓性白血病中之新穎功能及相關的分子機轉-焦點於抗藥性及血管新生調控相關基因探討
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行政院國家科學委員會

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100 探討血漿中pentraxin 3之變化在肺炎病人中扮演之角色
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新光醫療財團法人新光吳火獅紀念醫院

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99 研究C 型血管內皮生長因子在急性骨髓性白血病中之新穎功能及相關的分子機轉
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行政院國家科學委員會

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99 IL-6/Jak/Stat3 訊息路徑對卵巢癌紫杉醇抗藥性產生的功能性及機轉性研究-焦點於調控微小管的穩定性
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萬芳