張榮善(Chang, Jungshan) 教授

Email
js.chang@tmu.edu.tw
現   職
醫學科學研究所 教授

學經歷

學 歷

畢業學校與學位[修業時間]
美國紐約市立大學Biology 博士
1997/09~2002/05
美國紐約市立大學Biology 碩士
1994/09~1997/07
國立中興大學植物病理學系 學士
1984/09~1988/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學科學研究所教授
2024/08/01~
醫學科學研究所副教授
2013/02/01~2024/07/31
醫學科學研究所助理教授
2009/08/01~2013/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際醫學研究碩士學位學程副教授
2018/02/01 ~
國際醫學研究博士學位學程副教授
2018/02/01 ~
(舊)細胞治療與再生醫學國際博士學位學程籌備處副教授
2018/02/01 ~
國際醫學研究博士學位學程副教授
2016/11/01 ~ 2017/10/31
國際醫學研究碩士學位學程副教授
2016/11/01 ~ 2017/10/31

其它經歷

任職單位與職稱[起迄時間]
中山醫學大學免疫所助理教授
2009/02/19~2009/07/31
The Mount Sinai School of MedicineAssociate scientist
2007/10~2008/10
The Mount Sinai School of MedicinePost.Dr
2002/06~2007/09
The Mount Sinai School of MedicinePre. doctoral
2001/11~2002/05
Queens College of City University of New York Laboratory Instructor
1994/09~2001/05

專長與研究領域

學門領域
細胞生物學 (Cell Biology)
鐮狀紅血細胞病(Sickle Cell Disease)
白血球移動及運轉(Leukocyte Trafficking)
細胞 粘附分子(Adhesion Molecules)
先天免疫 系統(Innate Immunity)
學術專長
Intravital Microscopy
Surgical Surgical procedures
High Speed Multichannel Fluorescent Intravital Videomicroscopy
Confocal Microscopy
Fluroescent Microscopy
Fluorescent Microscopy

論文著作

清冊下載


1. 2024 Dirersa WB ,Kan TC,Chang J,Getachew G,Ochirbat S,Kizhepat S, Wibrianto A, Rasal A, Chen HA, Ghule AV, Chou, TH, Chang JY.. Engineering H2O2 Self-Supplying Platform for Xdynamic Therapies via Ru–Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy. . ACS Appl Mater Interfaces .2024

2. 2024 Cheng CC,Chang J,Ho AS,Sie ZL, Peng CL,Wang CL, Dev K, Chang CC. Tumor-intrinsic IFNα and CXCL10 are critical for immunotherapeutic efficacy by recruiting and activating T lymphocytes in tumor microenvironment . Cancer Immunology, Immunotherapy .2024 ;(73):1-18

3. 2024 Wang WC,Chang J,Lee CH,Chiang YW,Leu SJ,Mao YC, Chiang JR, Yang CK, Wu CJ, Yang YY. Phage display-derived alpaca nanobodies as potentialtherapeutics for Naja atra snake envenomation . Applied and Environmental Microbiology .2024 ;(90):1-23

4. 2024 Ochirbat S,Kan TC,Hsu CC,Huang TH,Chuang KH,Chen M, Cheng CC, Chang CC, Rahayu S, Chang J. The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers . Angiogenesis . .2024

5. 2024 Characterization of Chicken-Derived Antibody against Alpha-Enolase of Streptococcus pneumoniae . International Immunopharmacology .2024 ;(128)

6. 2023 Simpor leaf extract (Dillenia suffruticosa Martelli) induced apoptosis of the MCF-7 and HepG2 cell lines. . Journal of Applied Pharmaceutical Science .2023 ;(13):107-113

7. 2023 Ho YS. Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers . Molecular Therapy: Nucleic Acids .2023 ;(33):351-366

8. 2023 Wang CL,Ho AS,Chang CC,Sie ZL,Peng CL,Chang J, Cheng CC. Radiotherapy enhances CXCR3highCD8+ T cell activation through inducing IFNγ-mediated CXCL10 and ICAM-1 expression in lung cancer cells . Cancer Immunol Immunother .2023 ;(6):1865-1880

9. 2023 Getachew G,Tiena YC ,Kan TC,Dirersa WB,Wibrianto A,Orchirbat S, Chang J, Rasal AS,Gurav V, Kizhepata S, Chang JW. Defect-passivated metal halide perovskite quantum dots stabilized into biodegradable porous polydopamine nanoparticles for photothermal/ chemodynamic/gas therapy of cancer . Chemical Engineering Journal .2023 ;(467):1-20

10. 2023 Dirersa WB ,Kan TC,Getachew G,Wibrianto A,Ochirbat S, Rasal A, Chang J, Chang JY . Preclinical Assessment of Enhanced Chemodynamic Therapy by an FeMnOx-Based Nanocarrier: Tumor-Microenvironment-Mediated Fenton Reaction and ROS-Induced Chemotherapeutic for Boosted Antitumor Activity. . ACS Appl. Mater. Interfaces .2023 ;(15):55258-55275

11. 2023 A multifunctional nanocatalyst based on ultra-fluorescent carbon quantum dots for cascade enzymatic activity and stimuli-responsive chemotherapy of cancer . Carbon .2023 ;(208):191-207

12. 2022 Sorafenib suppresses radioresistance and synergizes radiotherapy-mediated CD8+ T cell activation to eradicate hepatocellular carcinoma . International Immunopharmacology .2022 ;(112):1-12

13. 2022 Fong TH. Caffeic Acid Phenethyl Ester Inhibits Basal Lipolysis by Activating PPAR-Gamma and Increasing Lipid Droplet-Associated Perilipin in Mature Rat Adipocytes . Evid Based Complement Alternat Med .2022 ;(2022):1-11

14. 2022 Airway Exposure to 1,3-Beta-d-Glucan Induces Airway Hyperresponsiveness in Guinea Pigs . ACS Pharmacology and Translational Science .2022 ;(5):169-175

15. 2022 Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4’-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2’-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers . Pharmaceutics .2022 ;(14):839

16. 2022 Single Cell Effects of Photobiomodulation on Mitochondrial Membrane Potential and Reactive Oxygen Species Production in Human Adipose Mesenchymal Stem Cells . Cells .2022 ;(11):972

17. 2022 Improving Tirapazamine (TPZ) to Target and Eradicate Hypoxia Tumors by Gold Nanoparticle Carriers . Pharmaceutics .2022 ;(14):847

18. 2022 Ding YF,Lin YW,Chiu WK,Lin CW,Yang YC,Chang LC, Chang J, Yang SF, Chien MH.. Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma . Aging .2022 ;(14):4500-4512

19. 2021 Irradiation Mediates IFNα and CXCL9 Expression in Non-Small Cell Lung Cancer to Stimulate CD8+ T Cells Activity and Migration toward Tumors . Biomedicines .2021 ;(9):1349 -1366

20. 2021 IFNγ-Mediated PD-L1 and MCL1 Expression in EGFR-Positive Lung Cancer to Augment CD8+ T Cells Cytotoxicity . Cells .2021 ;(10):215-232

21. 2020 Serum Neurofilament Light Polypeptide is a Biomarker for Inflammation in Cerebrospinal Fluid Caused by Fine Particulate Matter . Aerosol and Air Quality Research .2020 ;(20):1665-1674

22. 2020 Hsu YT,Chen HF,Lin WJ,Chang J,Mai FD. Reduction of Au3+ to distinctive Au-based materials by amphiphilic sodium dodecylbenzenesulfonate . RSC Advances .2020

23. 2020 Cheng,Lin HC,Chiang YW,Chang J,Sie ZL,Yang BL, Lim KH, Peng CL, Ho, AS, Chang YF. Nicotine exhausts CD8+ T cells against tumor cells through increasing miR‑629‑5p to repress IL2RB‑mediated granzyme B expression . Cancer Immunology, Immunotherapy .2020

24. 2020 Ho JH,Chang J,Yeh KT,Gong Z,Lin YM,Liu ZW. Prognostic and Clinical Implications of WNK Lysine Deficient Protein Kinase 1 Expression in Patients with Hepatocellular Carcinoma . In Vivo .2020

25. 2020 Trang NTT,Chang J,Chen WA,Chen CC,Chen HM,Chang CC, Fong TH. A Novel Microchip Technique for Quickly Identifying Nanogranules in an Aqueous Solution by Transmission Electron Microscopy: Imaging of Platelet Granules . Applied Sciences .2020 ;(10):4946

26. 2019 Chang YF,Lim KH,Chiang YW,Sie ZL,Chang J,Ho AS, Cheng CC. STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers . BMC Cancer .2019 ;(19):959-972

27. 2019 Lin CH , ,Lee HH,Kuei CH,Lin HY,Lu LS,Lee FP, Chang J, Wang JY, Hsu KC, and Lin YL. Nicotinic Acetylcholine Receptor Subunit Alpha-5 Promotes Radioresistance via Recruiting E2F Activity in Oral Squamous Cell Carcinoma . J. Clin. Med. .2019 ;(8):1-14

28. 2019 Wu MS,Chien CC,Chang J,Chen YC. Pro‐apoptotic effect of haem oxygenase‐1 in human colorectal carcinoma cells via endoplasmic reticular stress. . J Cell Mol Med .2019 ;(23):5692--5704

29. 2019 Ho YJ,Liu FC, ,Chang J,Shi B,Yeh KT,Lin YM, Lu JW.. High expression of meningioma1is correlated with reduced survival rates in colorectal cancer patients . Acta Histochem. .2019 ;(121):628-637

30. 2018 Cheng CC,Chou KF,Wu CW,Su NW,Peng CL,Su YW, Chang J, Ho AS, Lin HC, Chen CG, Yang BL, Chang YC, Chiang YW, Lim KH, Chang YF. EGFR-mediated interleukin enhancer-binding factor 3 contributes to formation and survival of cancer stem-like tumorspheres as a therapeutic target against EGFR-positive non-small cell lung cancer . Lung Cancer .2018 ;(116):80-89

31. 2018 Cheng CC ,Lin HC,Tsai KJ,Chiang YW,Lim KH, Chen CG, Su YW, Peng CL, Ho AS, Huang L, Chang YC, Lin HC, Chang , Chang YF. Epidermal growth factor induces STAT1 expression to exacerbate the IFNr‐mediated PD‐L1 axis in epidermal growth factor receptor‐positive cancers . Molecular Carcinogenesis .2018 ;(57):1588-1598

32. 2018 Cheng CC, Liao PN, Ho AS,Lim KH,Chang J,Su YW,Chen CG,Chiang YW, Yang BL, Lin HC, Chang YC, Chang CC, Chang YF.. STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening . Journal of Biomedical Science .2018 ;(25):60-71

33. 2017 Ho YJ,Lin YM,Huang YC,Chang J,Yeh KT,Lin LI, Gong Z, Tzeng TY, Lu JW. Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma . APMIS .2017 ;(125):985-995

34. 2017 Cheng CC,Chang J,Huang SC,Lin HC,Ho AS,Lim KH, Chang CC, Huang L, Chang YC, Chang YF, Wu CW. YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells . PLoS One .2017 ;(12):1-15

35. 2016 Targeting Mac-1-mediated leukocyte-RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage. . Experimental Hematology .2016 ;(44):940-946

36. 2016 Cheng CC,Guan SS,Yang HJ,Chang CC,Luo TY,Chang J, Ho AS. Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer . J Biomed Sci .2016 ;(23):18-27

37. 2016 Chen G,Chang J,Chang D,Pinho S,Jang JE,Frenette PS. Targeting Mac-1-mediated leukocyte–RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage . Experimental Hematology .2016 ;(44):940-946

38. 2016 Lu N,Alagesan M,Ho CL,Wei RJ,Kung CC,Chang J, Wen YS, Liu LK.. New fluorous ponytailed 4-[(2,2,2-trifluoroethoxy)methyl]pyridinium halide salts. . Acta Crystallogr C Struct Chem .2016 ;(72):1007-1011

39. 2015 Guan SS,Cheng CC,Ho AS,Wang CC,Luo TY,Liao TZ, Chang J, Wu CT, Liu SH. Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo . Oncotarget .2015 ;(6):36139-36155

40. 2014 Guan SS,Chang J,Cheng CC,Luo TY,Ho AS,Wang CC, Wu CT, Liu SH. Afatinib and its encapsulated polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo . Oncotarget .2014 ;(5):4868-4680

41. 2014 Ai-Sheng Ho,Chien-Hsin Chen,Chun-Chia Cheng,Chia-Chi Wang,Hua-Ching Lin,Tsai-Yueh Luo, Gi-Shih Lien, Jungshan Chang. Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers . Oncotarget .2014 ;(5):474-480

42. 2014 Ajnai G,Chiu A,Kan T,Cheng CC,Tsai TH,Chang J. Trends of Gold Nanoparticle-Based Drug Delivery System in Cancer Therapy . JOURNAL OF EXPERIMENTAL AND CLINICAL MEDICINE .2014 ;(6)

43. 2013 Cheng CC,Huang CF,Ho AS,Chang CS,Mai FD,Chen LY, Luo TY, Chang J. Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided (111)In-labeled polymeric micelles . Int J Nanomedicine .2013 ;(2013):1385-1391

44. 2012 Shu-Lin Liu,Yang-Chih Cheng,Chun-Chao Chang,Ai-Sheng Ho,Chun-Chia Cheng,Ling-Yun Chen, Chia-Chi Wang, Jungshan Chang. Identification of overexpressed cytokines as serum biomarkers of hepatitis C virus-induced liver fibrosis using bead-based flexible multiple analyte profiling. . African Journal of Biotechnology .2012 ;(11):7535-7541

45. 2012 Chun-Chia Cheng,,Jungshan Chang,Ling-Yun Chen,Ai-Sheng Ho,Ker-Jer Huang,Shui-Cheng Lee, Fu-Der Mai1, Chun-Chao Chang. Human neutrophil peptides 1-3 as gastric cancer tissue markers measured by MALDI-imaging mass spectrometry: implications for infiltrated neutrophils as a tumor target. . Dis Marker .2012 ;(32):21-31

46. 2012 Cheng CC, Lu N,Peng CL,Chang CC,Mai FD,Chen LY,Liao MH, Wang WM, Chang Js. Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system . PROTEOMICS .2012 ;(12):2584-2597

47. 2011 Shu-Lin Liu,Chun-Chia Cheng,Chun-Chao Chang,Chia-Chi Wang,Shui-Cheng Lee,Ai-Sheng Ho, Ling-Yun Chen. Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein . Journal of Biomedical Science .2011 ;(18):1-10

48. 2010 Chang JS,Patton J,Sarkar A,Erns B,Magnani JL,Frenette PS. GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. . Blood .2010 ;(116):1778-86

49. 2009 Hidalgo A, Chang J,Peired A,Jang J,Chiang, E,Frenette, PS. Heterotypic interactions by leukocyte microdomains contribute to acute inflammatory injuryinjury . Nature Medicine .2009 ;(14):384-391

50. 2008 Chang J,Shi PA,Chiang EY,Frenette,PS. Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion . Blood .2008 ;(111):915-923

51. 2007 Chiang EY,Hidalgo A,Chang J,Frenette PS. Imaging receptor microdomains on leukocyte subsets in live mice . Nature Methods .2007 ;(4):219-222

52. 2005 Kataymama Y,Hidalgo A,Chang J,frenette, PS. CD44 is a physiological E-selectin ligand on neutrophils. . Journal of experimental medicine .2005 ;(201):1183-1189

研究計畫

計畫名稱
108 乳癌細胞尼古丁受體表現與新穎抗體奈米藥物之臨床前試驗評估-α9尼古丁受體於小鼠模式探討致癌機制與奈米藥物之臨床前試驗評估(3/3)
補助單位
科技部

計畫名稱
108 貴校醫學科學研究所博士生甘慈珺君擬於109年4月3日至4月4日赴日本東京參加ICSTR東京-國際科學與技術研究會議,依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案,核定補助如說明,請查照。
補助單位
科技部

計畫名稱
107 乳癌細胞尼古丁受體表現與新穎抗體奈米藥物之臨床前試驗評估-α9尼古丁受體於小鼠模式探討致癌機制與奈米藥物之臨床前試驗評估(2/3)
補助單位
科技部

計畫名稱
106 石墨烯在生物安全方面的評估
補助單位
財團法人工業技術研究院

計畫名稱
106 乳癌細胞尼古丁受體表現與新穎抗體奈米藥物之臨床前試驗評估-α9尼古丁受體於小鼠模式探討致癌機制與奈米藥物之臨床前試驗評估(1/3)
補助單位
科技部

計畫名稱
105 微米咖啡殘渣再生利用-生物毒性評估研究計畫
補助單位
可茵生技有限公司

計畫名稱
104 探討藉抑制白血球浸潤對腦創傷的影響
補助單位
科技部

計畫名稱
103 探討含氟修飾之順鉑藥物的毒理機制對具順鉑抗藥性之大直腸腫瘤細胞
補助單位
臺北科技大學

計畫名稱
102 以MALDI與TOF-SIMS研究大腸癌病人血液與組織內CTGF與PTEN表現探討
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
101 奈米金鍵結標靶藥物afatinib用於治療HER2大量表現之癌症
補助單位
臺北醫學大學附設醫院

計畫名稱
101 以MALDI 與TO-SIMS研究大腸癌病人血液與組織內ghrelin與ghrelin受器表現變化
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
101 探討及研究免疫球蛋白(Intravenous Immunoglobulin ,IVIG)調控和抑制嗜中性白血球(neutrophils)的黏附聚集機制
補助單位
行政院國家科學委員會

計畫名稱
101 preparing the polyfluorinated 5,5-bipyridine-containing cisplatin analogues and the studies of their cytotoxicity and possible mechanism
補助單位
臺北科技大學

計畫名稱
101 利用蛋白質體技術探討藥物引起肝纖維化之分子機轉
補助單位
臺北醫學大學

計畫名稱
100 以MALDI與TOF-SIMS研究大腸癌組織Heme oxygenase-1與腫瘤相關蛋白及鐵離子表現變化
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
100 進行以腸道掃描鏡或膠囊內視鏡偵測大腸癌(2)
補助單位
國防部軍備局中山科學研究院

計畫名稱
100 探討及研究免疫球蛋白(Intravenous Immunoglobulin ,IVIG)調控和抑制嗜中性白血球(neutrophils)的黏附聚集機制
補助單位
行政院國家科學委員會

計畫名稱
100 利用蛋白質體技術探討藥物引起肝纖維化之分子機轉
補助單位
臺北醫學大學

計畫名稱
99 探討及研究免疫球蛋白(Intravenous Immunoglobulin ,IVIG)調控和抑制嗜中性白血球(neutrophils)的黏附聚集機制
補助單位
行政院國家科學委員會

計畫名稱
98 使用表面矽處理的碲化鎘量子點製成的抗氧化探針當成生物標記進而直接觀察動物活體內腫瘤與基質間的相互作用
補助單位
臺北醫學大學附設醫院

計畫名稱
98 分析S100A7(psoriasin)對轉移前的人乳腺癌微環境所扮演的角色;強調癌症和免疫細胞之間的交互影響
補助單位
臺北醫學大學附設醫院

計畫名稱
98 免疫球蛋白(Intravenous Immunoglobulin, IVIG)調控和抑制嗜中性白血球(Neutrophils)黏附聚集機制的研究及探討
補助單位
臺北醫學大學新聘教師計畫