吳駿翃(Wu, Alexander Jun-Hong) 教授

Email
chaw1211@tmu.edu.tw
現   職
轉譯醫學博士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
皇后大學解剖及細胞生物學 博士
1997/09~2005/06
皇后大學生化 學士
1993/09~1997/05

本校學術經歷

任職單位與職稱[起迄時間]
轉譯醫學博士學位學程教授
2024/02/01~
轉譯醫學博士學位學程副教授
2013/08/01~2024/01/31
轉譯醫學博士學位學程助理教授
2012/08/01~2013/07/31
轉譯醫學博士學位學程籌備處助理教授
2012/03/01~2012/07/31
放射線學科助理教授
2008/08/01~2012/02/29
生醫材料暨工程研究所(舊)博士後研究(計畫補助)
2006/09/01~2008/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際轉譯科學碩士學位學程副教授
2024/05/01 ~
(舊)國際轉譯科學博士學位學程籌備處副教授
2020/05/01 ~
醫學資訊研究所副教授
2019/11/01 ~
國際研究組組長
2014/11/19 ~ 2017/07/31
(舊)國際研究合作組組長
2014/08/01 ~ 2014/11/18

其它經歷

任職單位與職稱[起迄時間]
Ottana Health Research Institute博士後研究員
2005/05~2006/04

專長與研究領域

學門領域
生物學之生化及分子生物
血液科腫瘤科風濕免疫及感染
學術專長
生物科學類
生物科學類
醫學
Medical Science
癌症細胞生物學
癌症細胞生物學

論文著作

清冊下載


1. 2023 Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats . Biomed Pharmacother. .2023

2. 2023 In silico study of novel niclosamide derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidate . Arab J Chem .2023

3. 2023 Identification of INFG/STAT1/NOTCH3 as γ-Mangostin's potential targets for overcoming doxorubicin resistance and reducing cancer-associated fibroblasts in triple-negative breast cancer . Biomed Pharmacother. .2023 ;(163)

4. 2023 Novel Multi-Target Agent for c-MET/STAT3/AKT Signaling Axis . Int. J. Mol. Sci. .2023 ;(24)

5. 2023 Therapeutic potential of EGFR/mTOR/Nf-kb targeting small molecule for the treatment of non-small cell lung cancer . Am J Cancer Res .2023

6. 2023 Multi-omics identification of genetic alterations in head and neck squamous cell carcinoma and therapeutic efficacy of HNC018 as a novel multi-target agent for c-MET/STAT3/AKT signaling axis. . Int J Mol Sci .2023

7. 2023 In Silico Evaluation of HN-N07 Small Molecule as an Inhibitor of Angiogenesis and Lymphangiogenesis Oncogenic Signatures in Non-Small Cell Lung Cancer . Biomedicines .2023

8. 2023 Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent . Int J Mol Sci .2023

9. 2023 Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3–c]quinolin-12(12H)-one as potential breast cancer drugs . Arabian Journal of Chemistry .2023

10. 2023 Multiomics Study of a Novel Naturally Derived Small Molecule, NSC772864, as a Potential Inhibitor of Proto-Oncogenes Regulating Cell Cycle Progression in Colorectal Cancer . Cells .2023

11. 2023 Computational identification of novel signature of T2DM-induced nephropathy and therapeutic bioactive compounds from Azanza garckeana. . Am J Transl Res .2023

12. 2023 Preclinical Evaluation of a Novel Small Molecule LCC-21 to Suppress Colorectal Cancer Malignancy by Inhibiting Angiogenic and Metastatic Signatures . Cells .2023

13. 2022 Deciphering the immuno-pathological role of FLT, and evaluation of a novel dual inhibitor of topoisomerases and mutant-FLT3 for t . Am J Cancer Res .2022 ;(12):5140-5159

14. 2022 Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradioresistant Cell Cycle-Related Oncogenic Signatures . Cancers .2022

15. 2022 Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivativ . International Journal of Molecular Sciences .2022 ;(23)

16. 2022 Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin . Biology .2022

17. 2022 Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone . Computers in Biology and Medicine .2022 ;(148)

18. 2022 Biochemical and tissue physiopathological evaluation of the preclinical efficacy of Solanum torvum Swartz leaves for treating oxidative impairment in rats administered a β-cell-toxicant (STZ) . Biomedicine and Pharmacotherapy .2022

19. 2022 Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration . Front Cell Dev Biol .2022

20. 2022 Luteolin-Rich Extract of Thespesia garckeana F. Hoffm. (Snot Apple) Contains Potential Drug-Like Candidates and Modulates Glycemic and Oxidoinflammatory Aberrations in Experimental Animals . Oxidative Medicine and Cellular Longevity .2022 ;(2022):1-20

21. 2022 Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents . Biomed Pharmacother .2022

22. 2022 Transcriptomic discovery of a theranostic signature (SERPINE1/MMP3/ COL1A1/SPP1) for head and neck squamous cell carcinomas and identification of antrocinol as a candidate drug . Computers in biology and medicine .2022 ;(150)

23. 2022 Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule . Front. Immunol .2022

24. 2021 BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase. . Int J Biol Sci. .2021 ;(17):3224-3238

25. 2021 Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines . biomedicines .2021 ;(9):1-22

26. 2021 Multi-Omics Data Analysis of Gene Expressions and Alterations, Cancer-Associated Fibroblast and Immune Infiltrations, Reveals the Onco-Immune Prognostic Relevance of STAT3/CDK2/4/6 in Human Malignancies . Cancers .2021 ;(13):1-26

27. 2021 An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3β/β-Catenin/STAT3/CD44 Suppressor with Anti-Glioblastoma Properties . Int J Mol Sci .2021 ;(22):1-23

28. 2021 mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 are druggable candidates for N-(2,4-difluorophenyl)-2',4'-difluoro-4-hydroxybiphenyl-3-carboxamide (NSC765598), with consequent anticancer implications . Frontiers in Oncology .2021

29. 2021 Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types . Cancers .2021 ;(13):1-25

30. 2021 In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1 . Int J Mol Sci .2021 ;(22):1-20

31. 2021 Comprehensive Omics Analysis of a Novel Small-Molecule Inhibitor of Chemoresistant Oncogenic Signatures in Colorectal Cancer Cell with Antitumor Effects . Cells .2021 ;(10):1-21

32. 2021 Identification of Cancer Hub Gene Signatures Associated with Immune-Suppressive Tumor Microenvironment and Ovatodiolide as a Potential Cancer Immunotherapeutic Agent . Cancers .2021 ;(13):1-20

33. 2021 Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance . Cancers .2021 ;(13):1-27

34. 2021 MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types . Computational and Structural Biotechnology Journal .2021 ;(19):4970-4983

35. 2021 LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells . Journal of inflammation research .2021 ;(2021):4551-4565

36. 2021 Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate . Pharmaceutics .2021

37. 2021 Gamma-Mangostin Isolated from Garcinia mangostana Suppresses Colon Carcinogenesis and Stemness by Downregulating the GSK3β/β-Catenin/CDK6 Cancer Stem Pathway . phytomedicine .2021

38. 2021 A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling . Cells .2021 ;(10):1-20

39. 2021 In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer . Journal of inflammation research .2021 ;(14):4901-4913

40. 2021 Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives . Frontiers in Pharmacology .2021 ;(12)

41. 2021 Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment . J Inflamm Res .2021

42. 2021 Transcriptomic-Based Identification of the Immuno-Oncogenic Signature of Cholangiocarcinoma for HLC-018 Multi-Target Therapy Exploration . Cells .2021

43. 2020 Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages . Toxicol Appl Pharmacol . .2020

44. 2020 Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes . Am J Cancer Res .2020 ;(1):2237-2354

45. 2020 HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses . Cancers .2020 ;(12):1-18

46. 2019 ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients . J. Clin. Med .2019 ;(8):1070-1083

47. 2019 In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer . J Cell Mol Med. .2019 ;(8):1-13

48. 2019 The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells . Mol Imaging .2019 ;(18):1-13

49. 2019 Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts . Cancers .2019 ;(12):1-16

50. 2019 Wen YT,Wu AT,Bamodu OA,Wei Li,Lin CM,Yen Y, Chao TY, Mukhopadhyay D, Hsiao M, Huang HS. A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis . Cancers .2019 ;(11):1-18

51. 2018 Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway . Cancers .2018 ;(10):1-10

52. 2018 Chen JH,Wu A TH,Tzeng D TW,Huang CC,Tzeng YM,Chao TY. Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling . phytomedicine .2018 ;(52):70-78

53. 2018 Intensity-modulated radiotherapy with systemic chemotherapy improves survival in patients with nonmetastatic unresectable pancreatic adenocarcinoma: A propensity score-matched, nationwide, population-based cohort study. . Radiother Oncol .2018 ;(129):326-332

54. 2017 Hung YW, Wang WC, Chu CY, Hung CL, Changou CA, Yen Y, Kung HJ. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progressio . Nature communications .2017 ;(22):15874-15890

55. 2017 Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression . Cancer Letter .2017 ;(403):28-36

56. 2017 Huang TH,Wu SY,Huang YJ,Wei PL,Wu AT(,Chao TY. The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cells . Am J Cancer Res .2017 ;(7):1227-1237

57. 2017 Chang YC,Chi LH,Chang WM,Su CY,Lin YF,Chen CL, Chen MH, Chang PM, Wu AT, Hsiao M. Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis . Journal of hematology and oncology .2017 ;(10):0-0

58. 2017 Huang YJ,Yang CK,Wei PL,Huynh TT,Whang-Peng J,Meng TC, Hsiao M, Tzeng YM, Wu AT, Yen Y. Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways . Journal of Hematology and Oncology .2017 ;(10):0-0

59. 2016 Su YH,Huang WC,Huang TH,Huang YJ,Sue YK,Huynh TT, Hsiao M, Liu TZ, Wu ATH, Lin CM. Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes . Oncotarget .2016 ;(0):0-0

60. 2016 Wei Li,Su YK,Lin CM,Chao TY,Huang SP,Huynh TT, Jan HJ, Whang-Peng, Chiou JF, Wu AT, Hsiao M. Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes . Oncotarget .2016 ;(0):0-0

61. 2016 Hsiao YW,Lai TC,Lin YH,Su CY,Lee JJ,Liao AT, Lin YF, Hsieh SC, Wu AT, Hsiao M. Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity. . Oncotarget .2016 ;(0):0-0

62. 2015 Lin CS,Lin YC,Adebayo BO,Wu A,Chen JH,Peng YJ, Cheng MF, Lee WH, Hsiao M, Chao TY, Yeh CT. Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma . Cancer Lett .2015 ;(368):36-45

63. 2015 Chang TC,Yeh CT,Adebayo BO,Lin YC,Deng L,Rao YK, Huang CC, Lee WH, Wu AT, Hsiao M, Wu CH, Wa. 4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype . Toxicol Appl Pharmacol. .2015 ;(288):258-268

64. 2015 Huang CC,Lin CM,Huang YJ,Wei L,Ting LL,Kuo CC, Hsu C, JFC, Wu AT, Lee WH.. Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells . Biotechnol Appl Biochem. .2015 ;(0):0-0

65. 2015 Bamodu OA,Huang WC,Tzeng DT,Wu A,Wang LS,Yeh CT, Chao TY. Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity. . Cancer Letter .2015 ;(364):125-134

66. 2015 Su CM,Lee WH,Wu AT,Lin YK,Wang LS,Wu CH, Yeh CT. Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition . J Nutr Biochem .2015 ;(26):675-685

67. 2015 Zucha MA,Wu AT,Lee WH,Wang LS,Lin WW,Yuan CC, Yeh CT. Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer . Oncotarget .2015 ;(6):13255-13268

68. 2015 Huynh TT,Lin CM,Lee WH,Wu AT,Lin YK,Lin YF, Yeh CT, Wang LS. Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis . J Nutr Biochem .2015 ;(26):466-475

69. 2014 Huynh TT,Rao YK,Lee WH,Chen HA,Le TD,Tzeng DT, Wang LS, Wu AT, Lin YF, Tzeng YM, Yeh CT. Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/B-catenin signaling pathway and epithelial-mesenchymal transition . Toxicol in Vitro .2014 ;(28):552-561

70. 2013 Mak KK, Wu ATH,Lee WH,Chang TC,Chiou JF,Wang LS,Wu CH, Huang CYF, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA448 circuit. . Mol Nutr Food Res. .2013 ;(0):0-0

71. 2013 Yeh CT, Su CL,Huang CY,Lin JKY,Lee WH,Chang PMH,Kuo YL, Liu YW, Wang LS, Wu CH, Shieh YS, Jan YH, Chuang YJ, Hsiao M, Wu ATH. A preclinical evaluation of antimycin A as a potential anti-lung cancer stem cell agent. . Evidence-Based Complementary and Alternative Medicine .2013 ;(0):0-0

72. 2013 Lee CM, Wu ATH,Su YH,Lee WH,Chiou JF,Lin YK,Hsiao M, Wu CH, Yeh CT. Blue berry isolate, Pterostilbene, functions as a potential anti-cancer stem cell agent in suppressing irradiation-mediated enrichment of hepatoma stem cells. . Evidence-Based Complementary and Alternative Medicine .2013 ;(0):0-0

73. 2012 Yeh CT,Rao YK,Ye M,Wu WS,Chang TC,Wang LS, Wu CH, Wu AT, Tzeng YM. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging . Toxicol Appl Pharmacol .2012 ;(0):0-0

74. 2012 Lu HY, Chiou JF,Wu ATH,Tsai CY,Leu JD,Ting LL,Wang MF, Chen HY, Lin CT, Williams DF, Deng WP. The Effect of Diminished Osteogenic Signals on Reduced Osteoporosis Recovery in Aged Mice and . Biomaterials .2012 ;(0):0-0

75. 2012 Lin LC, Yeh CT,Kuo CC,Lee CM,Yen GC,Wang LS,Wu CH, Yang WC, Wu ATH. Sulforaphane Potentiates the Efficacy of Imatinib against Chronic Leukemia Cancer . J Agric Food .2012 ;(60):7031-7039

76. 2012 Cheng PW,Wu AT,Lu PJ,Yang YC,Ho WY,Lin HC, Hsiao M, Tseng CJ. Modulation of Central Control of Hypotensive Effects by Neuropeptide Y is Mediated through RSK Induced Activation of Endothelial Nitric Oxide Synthase . British Journal of Pharmacology .2012 ;(167):1148-1160

77. 2012 Yeh CT, Wu AT,Chang PM,Chen KY,Yang CN,Ho CC,Chen CC, Kuo YL, Lee PY, Liu YW, Yen CC, Hsiao M, Lu PJ, Lai JM, Wang LS, Wu CH, Chiou JF, Yang PC,. Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell . Am J Respir Crit Care Med. .2012 ;(0):0-0

78. 2012 Liu YP,Yang CJ,Hung MS,Yeh CT,Wu AT,Lee YC, Lai TC, Lee CH, Hsiao YW, Lu. Cisplatin selects for multidrug-resistant CD133+ . Cisplatin selects for multidrug-resistant CD133+ .2012 ;(0):0-0

79. 2011 Liu HY,Wu ATH,Tsai CY,Chou KR,Zeng R,Wang MF, Chang WC, Hwang SM, Su CH, Deng WP. The Balance between Adipogenesis and Osteogenesis in Bone Regeneration by Platelet–Rich Plasma for Age-related Osteoporosis . Biomaterials .2011 ;(0):0-0

80. 2011 wei hj, wu at,hsu ch,lin hp,cheng wf,su ch,chiu wt,whang-peng j, douglas fl, deng wp. The Development of a Novel Cancer Immunotherapeutic Platform Using Tumor-targeting Mesenchymal Stem Cells and a Protein Vaccine . molecular therapy .2011 ;(19):2249-2257

81. 2011 Chiou JF, Wu AT,Wang WT,Kuo TH,Gelovani JG,Lin IH,Wu CH, Chiu WT, Deng WP. A Preclinical Evaluation of Antrodia Camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging . Evid Based Complement Alternat Med .2011 ;(0):0-0

82. 2010 Tai CR,Wu AT,Chiou JF,Jan HJ,Wei HJ,Hsu CH, Lin CT, Chiu WT, Wu CW, Lee HM, Deng WP. The investigation of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging . BMC Cancer .2010

83. 2010 Rao YK,Wu AT,Geethangili M,Huang MT,Chao WJ,Wu CH, Deng WP, Yeh CT, Tzeng YM. Identification of Antrocin from Antrodia camphorata as a Selective and Novel . Chemical Research in Toxicology .2010

84. 2010 Tung JN,Chen YW,Hsu CH,Liu TZ,Hsieh PY,Ting LL, Ko HL, Chang YJ, Chiou JF, Wu AT. Normoxically Overexpressed Hypoxia Inducible Factor 1-alpha is Involved in Arsenic Trioxide Resistance Acquisition in Hepatocellular Carcinoma. . annals of surgical oncology .2010

85. 2009 Chen WH,Lai MT,Wu ATH,Wu CC,Gelovani JG,Lin CT, Hung SC, Chiu WT, Deng WP. In Vitro Stage-Specific Chondrogenesis of Mesenchymal Stem Cells Committed to Chondrocytes . Arthritis Rheum-US .2009 ;(60):450-459

86. 2008 Anupriwan A,Schenk M,Kongmanas K,Vanichviriyakit R,Santos DC,Yaghoubian A, Liu F, Wu A, Berger T, Faull KF, Saitongdee P, Sretarugsa P, Tanphaichitr N. Presence of Arylsulfatase A and Sulfogalactosylglycerolipid in Mouse Ovaries: Localization to the Corpus Luteum . Endocrinology .2008 ;(149):3942-3951

87. 2008 Lo WC,Hsu CH,Wu AT,Yang LY,Chen WH,Chiu WT, Lai WF, Wu CH, Gelovani JG, Deng WP. A novel cell-based therapy for contusion spinal cord injury using GDNF-delivering NIH3T3 cells with dual reporter genes monitored by molecular imaging . J Nucl Med .2008 ;(49):1512-1519

88. 2007 Wu AT,Sutovsky P,Xu W,van der Spoel AC,Platt FM,Oko R. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport . Dev Biol .2007 ;(312):471-483

89. 2007 Wu A,Anupriwan A,Iamsaard S,Charkrabandhu K,Santos DC,Rupar T, Tsang BK, Carmona E, Tanphaichitr N. Sperm surface arylsulfatase A can disperse the cumulus matrix of cumulus oocyte complexes . J Cell Physiol .2007 ;(213):201-211

90. 2007 Wu AT,Sutovsky P,Manandhar G,Xu W,Katayama M,Day BN, Park KW, Yi YJ, Xi YW, Prather RS, Oko R. PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization . J Biol Chem .2007 ;(282):12164-12175

91. 2003 Sutovsky P,Manandhar G,Wu A,Oko R. Interactions of sperm perinuclear theca with the oocyte: implications for oocyte activation, anti-polyspermy defense, and assisted reproduction . Microsc Res Tech .2003 ;(61):362-378


1. 2005 Wu A,Sutovsky P,Manandhar G,Katayama M,Day BN,Prather RS, Oko R. The involvement of a sperm specific WW domain binding protein in pronuclear formation during mammalian fertilization . XVIII North American Testis Workshop, Seattle, Washington, USA .2005

2. 2005 Wu A,Sutovsky P,Oko R. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport . 38th Annual meeting, Society for the study of reproduction, Quebec City, Canada .2005

3. 2002 Mountjoy JR,Wu ATH,Oko R. A RAB2 variant (PT24) is a prominent component of the bull sperm perinuclear theca . Queen's university 5th annual meeting for basic and clinical research trainees faculty of health sciences .2002

4. 2002 Sutovsky P,Wu A,Park KW,Prather RS,Carter DB,Takahashi D, Dominko T, Sutovsky M, Oko R. PT32: sperm perinuclear theca protein with protperties of the sperm-borne oocyte activating factor . 35th annual meeting, Society for the study of reproduction, Baltimore MD, USA .2002

5. 2001 Wu A,Oko R. PT32. A potential candidate for sperm borne oocyte activating factor . 7th international congress of Andrology, Montreal Quebec, Canada .2001

6. 2001 Wu A,Oko R. A potential sperm borne oocyte activating factor or cofactor . Queen's University 4th Annual meeting for basic and clinical research trainees faculty of health sciences .2001

7. 2000 Oko R,Sutovsky P,Tovich R,Wu A. The composition and role of the sperm perinuclear theca . French-Czech-Slovak Colloquium, international conference of reproductive biology, Slovak Academy of Sciences at Stara Lesna .2000

8. 1999 Wu ATH,Oko R. The characterization of a novel 32 kDa sperm perinuclear theca protein . Queen's University 2nd Anuunal Meeting for basic and clinical research trainees faculty of health sciences .1999

9. 1999 Wu ATH,Oko R. The characterization of a novel 32kDa sperm perinuclear theaca protein . The 39th American Society for Cell biology annual meeting, Washington DC, USA .1999

10. 1998 Oko R,Aul R,Wu A. The identity and possible role of sperm perinuclear theca proteins . Candadian Federation of Biological Societies 41st Anuunal Meeting, Edmonton, Canada .1998

11. 1997 Lawson V,Wu TH,Schalles U,Oko R. The molecular cloning and developmental expression of two novel mRNAs encoding putative 14kDa ODF and FS proteins of the rat sperm tail . The American Society for Cell Biology, Washington D.C .1997

12. 1997 Gong J,Wu TH,Oko R. A novel testicular protein, with sequence similarities to WW domain binding protein, is the major component of the bull sperm subacrosomal layer . The American Society for Cell Biology, Washington D.C .1997

研究計畫

計畫名稱
113 結合新奈米附載劑型與間質幹細胞治療系統應用於糖尿病危重肢體缺血 -利用多功能胜肽之特殊培養方法開發增強型間葉幹細胞和其外秘小體做為治療糖尿病危重肢體缺血之轉譯研究(3/3)
補助單位
國家科學及技術委員會

計畫名稱
113 探討魚針草酸透過重塑免疫微環境及標靶具免疫療法抗性頭頸癌幹細胞之轉譯研究
補助單位
國家科學及技術委員會

計畫名稱
112 結合新奈米附載劑型與間質幹細胞治療系統應用於糖尿病危重肢體缺血 -利用多功能胜肽之特殊培養方法開發增強型間葉幹細胞和其外秘小體做為治療糖尿病危重肢體缺血之轉譯研究(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 「補助國內研究生出席國際學術會議」The 53rd Annual Meeting of the Japanese Society for Spine Surgery and Related Research(研究生:國際醫學研究博士學位學程博士班BUI TUAN ANH君)
補助單位
國家科學及技術委員會

計畫名稱
112 「補助國內研究生出席國際學術會議」AACR年會2024(研究生:轉譯醫學博士學位學程博士班HUYNH THI LUU KIM HUONG君)
補助單位
國家科學及技術委員會

計畫名稱
111 探討倍半萜內酯 Antrocin 為先導化合物以及其奈米優化物針對抑制原神經到間質轉化達到治療腦癌幹細胞之轉譯研究
補助單位
國家科學及技術委員會

計畫名稱
111 結合新奈米附載劑型與間質幹細胞治療系統應用於糖尿病危重肢體缺血 -利用多功能胜肽之特殊培養方法開發增強型間葉幹細胞和其外秘小體做為治療糖尿病危重肢體缺血之轉譯研究(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 委託測試工業化量產前之肌肉萎縮新藥臨床前動物試驗研究計畫
補助單位
松陽生技股份有限公司

計畫名稱
109 預防肌肉萎縮新藥之臨床前轉譯研究研究計畫
補助單位
松陽生技股份有限公司

計畫名稱
105 化學全合成牛樟芝天然物安卓幸(Antrocin)以及其衍生物抗癌機制實驗研究計畫
補助單位
易宏生物科技股份有限公司

計畫名稱
105 探討牛樟芝萃取物在提高肝臟對於酒精分解功能以及保護肝臟的生物機制之研究計畫
補助單位
易宏生物科技股份有限公司

計畫名稱
104 2016第二屆史丹佛-台灣 ALDH2基因與人類疾病研討會
補助單位

計畫名稱
103 臨床前FGFR抑制劑對於抗藥性胰臟癌療效之評估
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衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
103 BLCFA1對於抑制惡性三陰性乳癌轉移功效之研究
補助單位
普惠德生技股份有限公司

計畫名稱
103 化學全合成牛樟芝天然物安卓幸(ANTROCIN)抗癌動物試驗研究計畫
補助單位
易宏生物科技股份有限公司

計畫名稱
103 探討BLCFA01在小鼠模式抗老話功能之研究
補助單位
普惠德生技股份有限公司

計畫名稱
102 探討LncRNA MALAT1 在惡性乳癌幹細胞生成之角色以及pterostilbene 對於透過抑制MALAT1而抑制乳癌幹細胞功能之研究
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
102 BLCFA1對於抑制惡性腫瘤生長功效之研究
補助單位
普惠德生技股份有限公司

計畫名稱
101 探討樟芝萃取物antrocin在抑制大直腸癌細胞轉移的效用及機制
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
101 應用分子造影模式探討蛋白疫苗結合幹細胞趨癌特性做為廣效性癌 症基因合併疫苗療法之臨床前研究評估
補助單位
行政院國家科學委員會

計畫名稱
101 探討Hscube2對於抑制乳癌幹細胞的機制及以其作為新藥開發之潛能
補助單位
臺北醫學大學

計畫名稱
100 探討氧化壓力在抗藥性乳癌幹細胞所扮演之角色及利用調控自由基藥物提高化療功效的可能性
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
100 探討以植物化學成分抑制β-catenin/PIN1訊息傳道路徑於肝癌幹細胞的發生
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
100 應用分子造影模式探討蛋白疫苗結合幹細胞趨癌特性做為廣效性癌 症基因合併疫苗療法之臨床前研究評估
補助單位
行政院國家科學委員會

計畫名稱
100 探討Hscube2對於抑制乳癌幹細胞的機制及以其作為新藥開發之潛能
補助單位
臺北醫學大學

計畫名稱
99 應用分子造影模式探討蛋白疫苗結合幹細胞趨癌特性做為廣效性癌 症基因合併疫苗療法之臨床前研究評估
補助單位
行政院國家科學委員會

計畫名稱
98 葉酸缺乏引發之氧化/氮化壓力在調控肝癌SK-Hep-1細胞的轉移傾向所扮演之角色
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
97 應用分子造影模式探討基因及細胞治療方法於非小細胞肺癌動物模式的研究
補助單位
行政院國家科學委員會