楊自森(Yang, Tzu-Sen) 副教授

Email
tsyang@tmu.edu.tw
現   職
生醫光機電研究所 所長
生醫光機電研究所 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
中央大學機械工程系 博士
1997/09~2003/06
成功大學航空太空工程研究所 碩士
1995/09~1997/06
淡江大學航空工程 學士
1991/09~1995/06

本校學術經歷

任職單位與職稱[起迄時間]
生醫光機電研究所副教授
2017/11/01~
生物醫學工程學系副教授
2017/03/01~2017/10/31
奈米醫學工程研究所副教授
2016/02/01~2017/02/28
生醫材料暨組織工程研究所副教授
2015/08/01~2016/01/31
牙體技術學系副教授
2014/02/01~2015/07/31
牙體技術學系助理教授
2010/02/01~2014/01/31
生醫材料暨工程研究所(舊)助理教授
2008/02/01~2010/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
生醫光機電研究所所長
2020/11/01 ~
牙體技術學系副教授
2017/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
清華大學生醫工程與環境科學系博士後研究
2005/08/01~2008/01/31
清華大學原子科學系博士後研究
2003/10/13~2005/07/31

專長與研究領域

學門領域
分子生醫光電
生物物理
奈米技術
細胞生物力學
生物力學
生醫材料
學術專長
生物力學
生物力學
生物單分子螢光技術
生物單分子操控技術

論文著作

清冊下載


1. 2023 Imaging and Histopathological Analysis of Microvascular Angiogenesis in Photodynamic Therapy for Oral Cancer . Cancers .2023

2. 2022 Li-Chern Pan,Nguyen-Le-Thanh Hang,Mamadi M.S Colley, Jungshan Chang,Yu-Cheng Hsiao,Long-Sheng Lu, Bing-Sian Li, Cheng-Jen Chang, Tzu-Sen Yang. Single Cell Effects of Photobiomodulation on Mitochondrial Membrane Potential and Reactive Oxygen Species Production in Human Adipose Mesenchymal Stem Cells . Cells .2022

3. 2022 Momoh Gbetuwa,Long-Sheng Lu,Tsung-Jen Wang,Yin-Ju Chen,Jeng-Fong Chiou,Tai-Yuan Su, Tzu-Sen Yang. Nucleus Near-Infrared (nNIR) Irradiation of Single A549 Cells Induces DNA Damage and Activates EGFR Leading to Mitochondrial Fission . Cells .2022

4. 2022 Biophotonic Effects of Low-Level Laser Therapy at Different Wavelengths for Potential Wound Healing . Photonics .2022

5. 2021 Shyuan-Yow Chen,Yung-Chieh Cho,Tzu-Sen Yang,Keng-Liang Ou,Wen-Chien Lan,Bai-Hung Huang, Takashi Saito, Chi-Hsun Tsai, Bou-Yue Peng, Yen-Chun Chuo, Hung-Yang Lin, Hsiao-Wei Chao, Christopher J. Walinski , and Muhammad Ruslin. A Tailored Biomimetic Hydrogel as Potential Bioink to Print a Cell Scaffold for Tissue Engineering Applications: Printability and Cell Viability Evaluation . Applied Sciences .2021 ;(11):829

6. 2021 Ping-Jen Hou,Chang-Yu Lee,Keng-Liang Ou,Wen-Chien Lan,Yen-Chun Chuo,Hung-Yang Lin, Hsiao-Wei Chao, Bai-Hung Huang, Takashi Saito, Hsin-Yu Tsai, Tzu-Sen Yang, Christopher J. Walinski, and Muhammad Ruslin. Calcium Release from Different Toothpastes after the Incorporation of Tricalcium Phosphate and Amorphous Calcium Phosphate . Applied Sciences .2021 ;(11):1848

7. 2021 Pei-Wen Peng,Jen-Chang Yang,Wei-Fang Lee,Chih-Yuan Fang,Chun-Ming Chang,I-Jan Chen, Chengpo Hsu, and Tzu-Sen Yang. Effects of Heat Treatment of Selective Laser Melting Printed Ti-6Al-4V Specimens on Surface Texture Parameters and Cell Attachment . Applied Sciences .2021 ;(11):2234

8. 2021 Jy-Jiunn Tzeng,Tzu-Sen Yang,Wei-Fang Lee,Hsuan Chen,Hung-Ming Chang. Mechanical Properties and Biocompatibility of Urethane Acrylate-Based 3D-Printed Denture Base Resin . Polymers .2021 ;(13):822

9. 2021 Peng PW, Huang CF,Hsu CY,Chen A,Ng HH,Cheng MS, Tsay S, Lai TY, Yang TS, Lee WF. Color Stability and Staining Susceptibility of Direct Resin-Based Composites after Light-Activated In-Office Bleaching . Polymers .2021

10. 2021 Yang TS,Chen MS,Huang CJ,Chen CY,Brangule A,Zarkov A, Kareiva A, Lin CK, Yang JC. A Novel Sol-Gel Bi2-xHfxO3+x/2 Radiopacifier for Mineral Trioxide Aggregates (MTA) as Dental Filling Materials . Applied Sciences .2021

11. 2021 Aditi P,Yang TS,Yang TI,Belem WF,Teng NC,Chen IW, Huang CS, Kareiva A, Yang JC. An Insight into Nano Silver Fluoride-Coated Silk Fibroin Bioinspired Membrane Properties for Guided Tissue Regeneration . Polymers .2021

12. 2021 Huang BH,Lu YJ,Lan WC,Ruslin M,Lin HY,Ou KL, Saito T, Tsai HY, Lee CH, Cho YC, Yang TS, Liu CM, Hou PJ. Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications . Metals .2021

13. 2021 Aditi P,Yang TS,Cheng SL,Hung CS,Brangule A,Kareiva A, Yang JC. A Novel One-Pot Synthesis and Characterization of Silk Fibroin/α-Calcium Sulfate Hemihydrate for Bone Regeneration . Polymers .2021

14. 2021 Syamsiah S,Chang CW,Lan WC,Ou KL,Huang BH,Lin YY, Saito T, Tsai HY, Chuo YC, Yang TS, Liu CM, Hou PJ. An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model . Applied Sciences .2021

15. 2021 Teng NC,Aditi P,Hsu WH,Huang CS,Lee WF,Lee TH, Yang TCK, Yang TS, Yang JC. Effect of gamma-polyglutamic acid/nano-hydroxyapatite paste on rehardening and prevention of surface etched enamel . Polymers .2021

16. 2021 Tzeng JJ,Yang TS,Lee WF,Chen H,Chang HM. Mechanical Properties and Biocompatibility of Urethane Acrylate-Based 3D-Printed Denture Base Resin . Polymers .2021

17. 2021 Yang TS,Shy S. The preferential accumulation and the settling velocity of small heavy particles in Taylor Couette flows . Journal of Mechanics .2021

18. 2021 Tzu-Sen Yang ,Shenqyang (Steven) Shy. THE PREFERENTIAL ACCUMULATION AND THE SETTLING VELOCITY OF SMALL HEAVY PARTICLES IN TAYLOR -COUETTE FLOWS . Journal of Mechanics .2021

19. 2021 Pei-Wen Peng,Jen-Chang Yang,Mamadi M.S Colley,Tzu-Sen Yang. An Optical Tweezers-Based Single-Cell Manipulation and Detection Platform for Probing Real-Time Cancer Cell Chemotaxis and Response to Tyrosine Kinase Inhibitor PD153035 . Photonics .2021

20. 2021 Guo-Shou Wang,Ji-Ying Chen,Wei-Cheng Chen,I-Chin Wei,Szu-Wei Lin,Kuang-Wen Liao, Tzu-Sen Yang, Ju-Fang Liu. Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma . Environmental Toxicology .2021

21. 2020 Keng-Liang Ou,Ping-Jen Hou,Bai-Hung Huang,Hsin-Hua Chou,Tzu-Sen Yang,Chiung-Fang Huang, akaaki Ueno. Bone Healing and Regeneration Potential in Rabbit Cortical Defects Using an Innovative Bioceramic Bone Graft Substitute. . Applied Sciences .2020 ;(10):6239

22. 2019 Chiung-Fang Huang,Mamadi M S Colley,Long-Sheng Lu,Chia-Yu Chang,Pei-Wen Peng,Tzu-Sen Yang. Performance characterization of continuous-wave laser-induced forward transfer of liquid bioink . Applied Physics Express .2019 ;(12):116504-116508

23. 2018 Ping-Jen Hou, Keng-Liang Ou,Chin-Chieh Wang,Chiung-Fang Huang,Muhammad Ruslin,Erwan Sugiatno, Tzu-Sen Yang, Hsin-Hua Chou. Hybrid micro/nanostructural surface offering improved stress distribution and enhanced osseointegration properties of the biomedical titanium implant. . Journal of the Mechanical Behavior of Biomedical Materials. .2018 ;(79):173-180

24. 2016 Keng-Liang Ou,Chao-Chia Weng,Chi-Chang Wu,Yun-Ho Lin,Hsi-Jen Chiang,Tzu-Sen Yang, James Wang, Yun Yen, Han-Yi Cheng, Erwan Sugiatno. Research of StemBios Cell Therapy on Dental Implants Containing Nanostructured Surfaces: Biomechanical Behaviors, Microstructural Characteristics, and Clinical Trial . Implant Dentistry .2016 ;(21):63-73

25. 2016 Keng-Liang Ou,Heng-Jui Hsu,Tzu-Sen Yang,Yun-Ho Lin,Chin-Sung Chen,Pei-Wen Peng. Osseointegration of titanium implants with SLAffinity treatment a histological and biomechanical study in miniature pigs . Clinical Oral Investigations .2016 ;(20):1515-1524

26. 2016 Dah-Shyang Tsai1,Tzu-Sen Yang,Yu-Sheng Huang1,Pei-Wen Peng,Keng-Liang Ou. Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size . International Journal of Nanomedicine .2016 ;(11):2531-2542

27. 2016 Wei-Chiang Hung,Fang-Mo Chang,Tzu-Sen Yang,Keng-Liang Ou,Che-Tong Lin, Pei-Wen Peng. Oxygen-implanted induced formation of oxide layer enhances blood compatibility on titanium for biomedical applications . Mater. Sci. Eng. C Mater. Biol. Appl. .2016

28. 2014 Chen KH,Wang KJ,Tsai ML,Wang KM,Adria AM,Cheng WC,Yang TS,Teng NC,Tan KP, Chang KS. Gene selection for cancer identification: a decision tree model empowered by particle swarm optimization algorithm . BMC Bioinformatics .2014 ;(20):49

29. 2014 Wei-Ju Chung,Yujia Cui,Feng-Yun J. Huang,Tzu-Hui Tu,Tzu-Sen Yang2,Jem-Mau Lo, ChiShiun Chiang, Ian C. Hsu1. 99mTc Pyrene Derivative Complex Causes Double-Strand Breaks in dsDNA Mainly through Cluster-Mediated Indirect Effect in Aqueous Solution . PLOS ONE .2014 ;(9):e10816-e10816

30. 2013 May-Show Chen,Pei-Wen Peng,Bing-Chun Liou,Hsiao-Chen Kuo,Keng-Liang Ou,Tzu-Sen Yang. Single-molecule manipulation and detection platform for studying cancer cell chemotaxis . J Polym Eng .2013 ;(0):1-7

31. 2013 Yang TS,Ou KL,Peng PW,Liou BC,Wang WT,Huang YC, Tsai CM, Su CH. Quantifying membrane permeability of amphotericin B ion channels in single living cells . Biochim Biophys Acta-Biomembranes .2013 ;(1828):1794-1801

32. 2013 Tzu-Sen Yang,Mao-Suan Huang,Mao-Sheng Wang,Ming-Hong Lin,Meng-Yuan Tsai,Pei-Yi Wang. Effect of Electrical Discharging on Formation of Nanoporous Biocompatible Layer on Ti-6Al-4V Alloys . Implant Dent .2013 ;(22):374-379

33. 2013 Yu-Hao Chan,Yushan-Sophie Chang,Yun-Dun Shen,Tzu-Sen Yang,Shih-Fu Ou,Ya-Ju Hsu, Mao-Suan Huang, Keng-Liang Ou. Comparative In Vitro Osteoinductivity Study of HA and a-TCP/HA Bicalcium Phosphate . Int. J. Appl. Ceram. Technol .2013

34. 2013 Chiung-Fang Huang,Pei-Wen Peng,Chih-Ming Cheng,Jing-Shin Tsai,Wei-Ting Wang,Chien-Ting Hsu, Keng-Liang Ou, Tzu-Sen Yang. Direct Visualization of DNA Recognition by Restriction Endonuclease EcoRI . Journal of Experimental & Clinical Medicine .2013 ;(5):25-29

35. 2013 Wei-Fang Lee,,Tzu-Sen Yang,Yi-Chieh Wu,Pei-Wen Peng. Nanoporous Biocompatible Layer on Ti-6Al-4V Alloys Enhanced Osteoblast-like Cell Response . Journal of Experimental and Clinical Medicine .2013 ;(5):92-96

36. 2012 C. M. Cheng,M. C. Chang,Y. F. Chang,W. T. Wang,C. T. Hsu,J. S. Tsai, C. Y. Liu, C. M. Wu, K. L. Ou,T. S. Yang. Optical Tweezers-Assisted Cross-Correlation Analysis for a Non-intrusive Fluid Temperature Measurement in Microdomains . Japanese Journal of Applied Physics .2012 ;(51):067002-067005

37. 2011 May-Show Chen,Chia-Yeh Liu,Wei-Ting Wang,Chien-Ting Hsu,Chih-Ming Cheng,Jing-Shin Tsai, Keng-Liang Ou and Tzu-Sen Yang. Probing Real-Time Response to Multitargeted Tyrosine Kinase Inhibitor 4-N-(3′-Bromo-Phenyl)Amino-6,7-Dimethoxyquinazoline in Single Living Cells Using Biofuntionalized Quantum Dots . Journal of Nanomedicine & Nanotechnology .2011 ;(2):100011-100011

38. 2011 Cheng CM,Lee YJ,Wang WT,Hsu CT,Tsai JS,Wu CM, Ou KL, Yang TS*. Determining the Binding Affinity Constant of Tyrosine Kinase Inhibitor PD153035 to DNA Using Optical Tweezers . Biochemical and Biophysical Research Communications .2011 ;(404):297-301

39. 2011 Cheng CM,Lee YJ,Wang WT,Hsu CT,Tsai JS,Wu CM, Ou KL, Yang TS. Determining the Binding Affinity Constant of Tyrosine Kinase Inhibitor PD153035 to DNA Using Optical Tweezers . Biochemical and Biophysical Research Communications .2011 ;(404):297-301

40. 2011 Chen MS,Liu CY,Wang WT,Hsu CT,Cheng CM,Tsai JS , Ou KL , Yang TS. Probing Real-Time Response to Multitargeted Tyrosine Kinase Inhibitor 4-N-(3′-Bromo-Phenyl)Amino-6,7-Dimethoxyquinazoline in Single Living Cells Using Biofuntionalized Quantum Dots . Journal of Nanomedicine and Nanotechnology .2011 ;(2)

41. 2010 Tzu-Sen Yang,Yujia Cui,Chien-Ming Wu,Jem-Mau Lo,Chi-Shiun Chiang,Wun-Yi Shu, Wei-Ju Chung, Chung-Shan Yu, Kuo-Ning Chiang, Ian C. Hsu. Molecular dynamics: DNA takes a stretch . NPG Asia Materials (Research Highlight) .2010 ;(2):45

42. 2009 Yang TS,Cui Yujia,Wu CM,Lo JM,Chiang CS,Shu WY, Chung WJ, Yu CS, Chiang KN, Hsu Ian C.. Determining the Zero-Force Binding Energetics of Intercalated DNA Complex Using Single Molecule Approach . ChemPhysChem, .2009 ;(10):2791-2794

43. 2008 Yang TS,Cui Yujia,Wu CM,Lo JM,Shu WY,Chiang CS, Chiang KN, Yu CS, Lo ST, Hsu Ian C. Nanodosimetry Study by Single Molecule Approaches . Biophysical Journal .2008 ;(94):2835

44. 2008 Yang T S,Cui Yujia,Wu CM,Lo JM,Chiang CS,Shu WY, Yu CS, Chiang KN, Hsu Ian C.. Measurement of The Binding Affinity of Intercalated DNA Complex by Stretching Single DNA Molecules with Optical Tweezers . Biophysical Journal .2008 ;(94):1713

45. 2007 Yang T S,Cui Yujia,Wu CM,Lo JM,Chiang CS,Shu WY, Hsu Ian C. Single molecule approach to detect DNA double-strand break by Auger electrons . Biophysical Journal .2007

46. 2005 楊自森,吳見明,蔡旻龍,莊淳宇,崔豫笳,許志楧. 分子生醫光電科學與技術 . 物理雙月刊 .2005 ;(27):670-686

47. 2005 楊自森,吳見明,蔡旻龍,許志楧. 生醫光電檢測技術 . 機械工業雜誌 .2005 ;(265):188-195

48. 2005 Yang TS,Shy SS. Spatiotemporal Intermittency Measurements in A Gas-Phase Near-Isotropic Turbulence Using High-Speed DPIV and Wavelet Analysis . Journal of Mechanics .2005 ;(21):157-169

49. 2005 Yang TS,Shy SS. Two-Way Interaction between Solid Particles and Air Turbulence: Particle Settling Rate and Turbulence Modification Measurements . Journal of Fluid Mechanics .2005 ;(526):171-216

50. 2003 Yang TS,Shy SS. The Settling Velocity of Heavy Particles in an Aqueous Near-Isotropic Turbulence . Physics of Fluids .2003 ;(15):868-880

51. 2001 Chang NW,Shy SS,Yang SI,Yang TS. Spatially Resolved Flamelet Statistics for Reaction Rate Modeling Using Premixed Methane-Air Flames in a Near-Homogeneous Turbulence . Combustion and Flame .2001 ;(127):1880-1894

52. 1999 Shy SS,I WK,Lee EI,Yang TS. Experimental Analysis of Flame Surface Density Modeling for Premixed Turbulent Combustion Using Aqueous Autocatalytic Reactions . Combustion and Flame .1999 ;(118):606-618


1. 2003 Yang TS,Shy SS. A Gas-Phase Near-Isotropic Turbulence and Its Wavelet Analysis for Studying Fine-Scale Intermittency . Kluwer Academic Publishers .2003

2. 2003 Jiang LJ,Shy SS,Yang TS,Lee JH. Four-Dimensional Measurements of the Structure of Dissipative Scales in An Aqueous Near-Isotropic Turbulence . Kluwer Academic Publishers .2003

研究計畫

計畫名稱
112 養豬場污泥微生物菌叢分析
補助單位
財團法人工業技術研究院

計畫名稱
111 利用NIH3T3細胞探討光生物調控對傷口癒合過程之影響
補助單位
國家科學及技術委員會

計畫名稱
111 建立粒線體生物標誌探討近紅外光及其光熱效應與癌症藥物對癌細胞粒線體動力學之影響
補助單位
國家科學及技術委員會

計畫名稱
110 近紅外雷射光源光生物調控輻照度對不同代數人類脂肪幹細胞粒線體膜電位調控之影響
補助單位
國家科學及技術委員會

計畫名稱
110 探討 830 nm 低能量雷射光對單細胞生物層級的黑色素細胞內 ROS 與 Melanin的影響並評估其應用於白髮治療之潛力
補助單位
國家科學及技術委員會

計畫名稱
110 斑馬魚評估比較(含鋅與含鈉)電解氧化水之癒合效果實驗研究計畫
補助單位
邁士生技股份有限公司

計畫名稱
110 光生物調控與富血小板纖維蛋白支架對脂肪幹細胞軟骨分化能力之影響
補助單位
臺北醫學大學

計畫名稱
109 導入數位光學元件應用於斑馬魚尾鰭再生之遠端近紅外光生物調控系統研發
補助單位
科技部

計畫名稱
108 高精準度低能量雷射光治療系統之研發
補助單位
科技部

計畫名稱
108 奈米陣列結構應用於可調控細胞行為之人工微環境元件材料設計與製程開發
補助單位
臺北醫學大學

計畫名稱
107 利用低能量光治療活化NF-kB訊息傳遞迴路之單一活細胞及時監測
補助單位
科技部

計畫名稱
106 單一細胞層級NF-κB動力學於TNF-α訊息傳遞迴路之模型建立(3/3)
補助單位
科技部

計畫名稱
106 博士班學生柯利本(107)年2月17日至21日赴美國舊金山出席「62nd Annual Meeting of the Biophysical Society」會議
補助單位
外交部

計畫名稱
105 單一細胞層級NF-κB動力學於TNF-α訊息傳遞迴路之模型建立(2/3)
補助單位
科技部

計畫名稱
105 單一細胞層級NF-κB動力學於TNF-α訊息傳遞迴路之模型建立(2/3)
補助單位
科技部

計畫名稱
105 貴校牙體技術學系闕琬珊同學訂於本(106)年6 月17 日至20 日參加「Single-CellBiophysics:Measurement, Modulation, andModeling」國際研討會
補助單位
外交部

計畫名稱
104 腫瘤壞死因子 TNF-α 與轉錄因子NFκB 振盪表現之時間空間關聯性研究
補助單位
科技部

計畫名稱
104 單一細胞層級NF-κB動力學於TNF-α訊息傳遞迴路之模型建立(1/3)
補助單位
科技部

計畫名稱
104 單一細胞層級NF-κB動力學於TNF-α訊息傳遞迴路之模型建立(1/3)
補助單位
科技部

計畫名稱
103 利用奈米生醫技術評估遷移刺激因子對細胞層級傷口癒合行 為之影響
補助單位
科技部

計畫名稱
103 奈米生醫技術探討小分子藥物MM-IGD-AZ-2對於細胞遷移能力之影響
補助單位
科技部

計畫名稱
103 奈米級氧化鈰粒子混合葡萄聚醣之製備與抗菌應用
補助單位
臺灣科技大學

計畫名稱
102 單一細胞層級兩性黴素B 離子通道作用機制之及時監測:由膜外到膜內
補助單位
行政院國家科學委員會

計畫名稱
102 單一細胞層級兩性黴素B 離子通道作用機制之及時監測:由膜外到膜內
補助單位
科技部

計畫名稱
101 利用奈米生醫技術進行單一細胞層級癌細胞趨化性時空調控之即時監測
補助單位
行政院國家科學委員會

計畫名稱
100 利用生物單分子技術進行藥物分子與DNA結合反應之熱力學參數圖譜定量量測
補助單位
行政院國家科學委員會

計畫名稱
100 前瞻低氮氧化物合成氣燃燒器開發(II)
補助單位
行政院國家科學委員會

計畫名稱
98 以生醫光電為基礎之生物標誌感測器於居家照護之研究
補助單位
臺北醫學大學附設醫院

計畫名稱
98 利用功能化量子點以及生物單分子技術進行單細胞層級癌症檢測之研究
補助單位
臺北醫學大學附設醫院

計畫名稱
98 利用功能化量子點以及生物單分子技術進行單細胞層級癌症檢測之研究
補助單位
臺北醫學大學附設醫院

計畫名稱
96 限制性內切核酸酶與DNA結合以及切除之動態行為研究
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
96 利用單分子操控術探討限制性內切核酸酶與DNA結合與切除之動態行為研究
補助單位
臺北醫學大學新聘教師計畫