| 1. |
2024
Tze-Sian Chan,Li-Hsin Cheng,Chung-Chi Hsu,Pei-Ming Yang,Tai-Yan Liao,Hsiao-Yen Hsieh, Pei-Chun Lin, Wei-Chun HuangFu, Chih-Pin Chuu, Kelvin K. Tsai.
ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
. Molecular Oncology
.2024
;(18):562-579
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| 2. |
2024
Po-Yu Chou,Mei-Jung Lai,Kelvin K. Tsai,Li-Hsin Cheng,Yi-Wen Wu,Mei-Chuan Chen, Shiow-Lin Pan, Hsiu-O Ho, Kunal Nepali, Jing-Ping Liou.
Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids
. Journal of Medicinal Chemistry
.2024
;(67):17207-17225
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| 3. |
2024
Di-Wei Tang,I-Chung Chen,Po-Yu Chou,Mei-Jung Lai, Zheng-Yang Liu,Kelvin K. Tsai, Li-Hsin Cheng, Jian-Xun Zhao, Er-Chieh Cho, Hung-Hsuan Chang, Tony Eight Lin, Kai-Cheng Hsu, Mei-Chuan Chen, Jing-Ping Liou.
HSP90/LSD1 dual inhibitors against prostate cancer as well as patient-derived colorectal organoids
. European Journal of Medicinal Chemistry
.2024
;(278):116801
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| 4. |
2024
Ting-Yu Chang,Yan Yan, Zih-Yao Yu, Moeez Rathore, Nian-Zhe Lee,Hui-Ju Tseng, Li-Hsin Cheng, Wei-Jan Huang, Wei Zhang, Ernest R Chan, Yulan Qing, Ming-Lun Kang, Rui Wang, Kelvin K Tsai, John J Pink, William E Harte, Stanton L Gerson, Sung-Bau Lee.
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
. Journal of Clinical Investigation
.2024
|
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| 5. |
2023
Li-Hsin Cheng,Chung-Chi Hsu,Hung-Wen Tsai,Wen-Ying Liao,Pei-Ming Yang,Tai-Yan Liao, Hsiao-Yen Hsieh, Tze-Sian Chan, Kelvin K. Tsai.
ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression
. Cancer Research
.2023
;(83):830-844
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| 6. |
2023
Tsai KK,Bae BI,Hsu CC,Cheng LH,Shaked Y.
Oncogenic ASPM is a regulatory hub of developmental and stemness signaling in cancer
. Cancer Research
.2023
;(83):2993-3000
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| 7. |
2022
Ching-Yu Lin,Bi-Juan Wang,Yu-Ke Fu,Chieh Huo,Ya-Pei Wang,Bo-Chih Chen, Wei-Yi Liu, Jen-Chih Tseng, Shih Shen Jiang, Zong-Lin Sie, Kelvin K Tsai, Chiou-Hwa Yuh, Wen-Ching Wang, Hsing-Jien Kung, Chih-Pin Chuu.
Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism
. Clinical and Translational Medicine
.2022
;(12):e764
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| 8. |
2022
Kelvin K Tsai,Shenq-Shyang Huang,Jason J. Northey,Wen-Ying Liao,Chung-Chi Hsu,Li-Hsin Cheng , Michael E. Werner, Chih-Pin Chuu, Chandrima Chatterjee, Jonathon N. Lakins, Valerie M. Weaver.
Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and anti-tumor immunity
. Nature Cancer
.2022
;(3):734-752
|
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| 9. |
2021
Chung-Chi Hsu,Wen-Ying Liao,Kwang-Yu Chang,Tze-Sian Chan,Po-Jui Huang,Chun-Ting Chiang, Yan-Shen Shan, Lin-Hsin Cheng, Tai-Yan Liao, Kelvin K. Tsai.
A multi-mode Wnt- and stemness-regulatory module dictated by FOXM1 and ASPM isoform I in gastric cancer
. Gastric Cancer
.2021
;(24):624-639
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| 10. |
2021
Shenq-Shyang Huang,Wen-Ying Liao,Chung-Chi Hsu,Tze-Sian Chan,Tai-Yan Liao,Pei-Ming Yang, Li-Tzong Chen, Shian-Ying Sung, Kelvin K. Tsai.
A Novel Invadopodia-Specific Marker for Invasive and Pro-Metastatic Cancer Stem Cells
. Frontiers in Oncology
.2021
;(11):638311
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| 11. |
2020
Liao WY,Hsu CC,Chan TS,Yen CJ,Chen WY,Pan HW, Tsai KK.
Dishevelled-1-regulated superpotent cancer stem cells mediate Wnt heterogeneity and tumor progression in hepatocellular carcinoma
. Stem Cell Reports
.2020
;(14):462-477
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| 12. |
2020
Michael Timaner,Kelvin K Tsai,Yuval Shaked.
The multifaceted role of mesenchymal stem cells in cancer
. Seminars in Cancer Biology
.2020
;(60):225-237
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| 13. |
2020
Chiang NJ,Tsai KK,Hsiao CF,Yang SH,Hsiao HH,Shen WC, Hsu C, Lin YL, Chen JS, Shan YS, Chen LT.
A multicenter, phase I/II trial of biweekly S-1, leucovorin, oxaliplatin and gemcitabine in metastatic pancreatic adenocarcinoma-TCOG T1211 stud
. European Journal of Cancer
.2020
;(124):123-130
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| 14. |
2019
Lin CY,Wang BJ,Chen BC,Tseng JC,Jiang SS,Tsai KK, Shen YY, Yuh CH, Sie ZL, Wang WC, Kung HJ, Chuu CP.
Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc
. Cancers
.2019
;(11):E1785
|
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| 15. |
2019
Tze-sian Chan,Yuval Shaked,Kelvin K. Tsai.
Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers
. Frontiers in Oncology
.2019
;(9):688-688
|
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| 16. |
2019
Hsu CC,Liao WY,Chan TS,Chen WY,Lee CT,Shan YS, Huang PJ, Hou YC, Li CR, Tsai KK.
The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis
. Journal of Pathology
.2019
;(249):498-508
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| 17. |
2019
Kelvin K. Tsai,Tze-Sian Chan,Yuval Shaked.
Next Viable Routes to Targeting Pancreatic Cancer Stemness: Learning from Clinical Setbacks
. Journal of Clinical Medicine
.2019
;(8):702-702
|
|
| 18. |
2018
Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY, Li CR, Lin CY, Huang SP, Chen LT, Tsai KK.
ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling
. Oncogene
.2018
;(38):1340-1353
|
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| 19. |
2017
Nicolas Andre,Kelvin Tsai,Manon Carre,Eddy Pasquier.
Metronomic chemotherapy: direct targeting of cancer cells after all?
. Trends in Cancer
.2017
;(3):319-325
|
|
| 20. |
2017
Liao WY,Chan TS,Tsai KK.
The novel roles of stromal fibroblasts in metronomic chemotherapy: focusing on cancer stemness and immunity
. Journal of Cancer Research and Practice
.2017
;(4):123-126
|
|
| 21. |
2017
Chang KY,Huang CT,Hsu TI,Hsu CC,Liu JJ,Chuang CK, Hung JJ, Chang WC, Tsai KK, Chuang JY.
Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma
. Biochem. Biophys. Res. Commun.
.2017
;(493):14-19
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|
| 22. |
2016
Chan TS,Hsu CC,Pai VC,Liao WY,Huang SS,Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jian KY, Chu JM, Lien GS, Weaver VM,Tsai KK.
Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells
. The Journal of Experimental Medicine
.2016
;(213):2967-2988
|
|
| 23. |
2014
Chen JY,Li CF,Kuo CC,Tsai KK,Hou MF,Hung WC.
Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression
. Breast Cancer Research
.2014
;(16):410
|
|
| 24. |
2013
Lin CY,Huo C,Kuo LK,Hiipakka RA,Jones RB,Lin HP, Hung Y, Su LC, Tseng JC, Kuo YY, Want YL, Fukui Y, Kao YH, Kokontis JM, Yeh CC, Chen L, Yang.
Cholestane-3β, 5α, 6β-triol suppresses proliferation, migration, and invasion of human prostate cancer cells
. Proceedings of the National Academy of Sciences
.2013
;(8):e65734
|
|
| 25. |
2013
Wang WY,Hsu CC,Wang TY,Li CR,Hou YC,Chu JM, Lee CT, Liu MS, Su JJ, Jian KY, Huang SS, Jiang SS, Shan YS, Lin PW, Shen YY, Lee MT, etc..
A Gene Expression Signature of Epithelial Tubulogenesis and a Role for ASPM in Pancreatic Tumor Progression
. Gastroenterology
.2013
;(145):1110-1120
|
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| 26. |
2013
Chien CC,Kempson IM,Wang CL,Chen HH,Hwu Y,Chen NY, Lee TK, Petibois C, Tsai KK, Liu MS, Chang KY, Yang CS, Margaritondo G.
Complete microscale profiling of tumor microangiogenesis
. Biotechnology Advances
.2013
;(31):396-401
|
|
| 27. |
2013
Li CR,Su JJ,Wang WY,Lee MT,Huang SS,Jian KY, Li CF, Shen KH, Hsu JM, Chen M, Jian SS, Chen CK, Weaver VM, Tsai KK.
Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer
. The American Journal of Pathology
.2013
;(182):363-374
|
|
| 28. |
2012
Chan CH,Li CF,Yang WL,Gao Y,Lee SW,Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Sarbassov D, Nakayama KI, Lin HK.
The Skp2-SCF ubiquitin ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis.
. Cell
.2012
;(149):1098-1111
|
|
| 29. |
2012
Cheng HH,Cheng CK,Yan JL,Chen HL,Lin WC,Wang KH, Tsai KK, Guven H, Flaberg E, Szekely L, Klein G, Wu KK.
Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan
. Proceedings of the National Academy of Sciences
.2012
;(109):13231-13236
|
|
| 30. |
2012
Chang HS,Chu P,Peng SL,Mao TL,Shan YS,Tsai KK, Yu WC.
Kruppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma
. The American Journal of Pathology
.2012
;(181):423-430
|
|
| 31. |
2010
Gilbert PM,Mouw JK,Unger MA,Lakins JN,Gbegnon MK,Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM.
HoxA9 regulates BRCA1 expression to modulate mammary tissue growth and survival
. Journal of Clinical Investigation
.2010
;(120):1535-1550
|
|
| 32. |
2009
Tsai KK,Sturat J,Chuang YY,Little JB,Yuan ZM.
Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant
. Radiation Research
.2009
;(172):306-313
|
|
| 33. |
2005
Stuart JR,Kawai H,Tsai KK,Chuang EY,Yuan ZM.
c-Abl regulates early growth response protein (EGR1) in response to oxidative stress
. Oncogene
.2005
;(24):8085-8092
|
|
| 34. |
2005
Tsai KK,Chuang YY,Little J,Yuan ZM.
Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment
. Cancer Research
.2005
;(65):6734-6744
|
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