林景堉(Lin, Ching-Yu) 教授

Email
cylin@tmu.edu.tw
現   職
醫學生物科技博士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立台灣大學農業化學所 博士
1992/06~1997/09
國立台灣大學公衛流病所 碩士
2005/02~2007/01
國立台灣大學農業化學所 碩士
1989/09~1991/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學生物科技博士學位學程教授
2020/07/01~
醫學檢驗暨生物技術學系教授
2018/08/01~2020/06/30
醫學檢驗暨生物技術學系副教授
2012/08/01~2018/07/31
醫學檢驗暨生物技術學系助理教授
2011/02/01~2012/07/31
醫學檢驗暨生物技術學系(舊)助理教授
2007/08/14~2011/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學檢驗暨生物技術學系教授
2020/11/01 ~
醫學生物科技博士學位學程籌備處副教授
2015/02/01 ~
癌症生物學與藥物研發博士學位學程
2014/02/01 ~
醫學科學研究所助理教授
2007/08/14 ~

其它經歷

任職單位與職稱[起迄時間]
國立宜蘭大學兼任助理教授
2003/09~2005/06
金車股份有限公司主任
1997/09~2007/08
中央研究院博士後研究
1997/07~1997/11

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2024 Meng-Huan Lei,Po-Wen Hsu,Yin-Tai Tsai, Chen-Chi Chang, I-Jung Tsai,Hung Hsu, Ming-Hui Cheng, Ying-Li Huang, Hung-Tse Lin, Yu-Cheng Hsu, Ching-YuLin. LowLevels of IgM Recognizing 4-Hydroxy-2-Nonenal-Modified Apolipoprotein A-I Peptide and Its Association with the Severity of Coronary Artery Disease in Taiwanese Patients . Curr. Issues Mol. Biol. .2024

2. 2023 Hsiu-Mei Chen,Yi-Hsuan Tsai,Chien-Yi Hsu,Yong-Yi Wang,Cheng-En Hsieh, Jin-Hua Chen, Yu-Sheng Chang and Ching-Yu Lin. Peptide-Coated Bacteriorhodopsin-Based Photoelectric Biosensor for Detecting Rheumatoid Arthritis . Biosensors .2023

3. 2022 Ching-Yu Lin,Uyen Thi Nhat Nguyen,Han-Yun Hsieh,Hidetoshi Tahara,Yu-Sheng Chang,Bing-Yu Wang,Bing-Chen Gu,Yu-Han Dai,Chia-Che Wu,I-Jung Tsai,Yu-Jui Fan. Peptide-based electrochemical sensor with nanogold enhancement for detecting rheumatoid arthritis . Talanta .2022 ;(236):122886-122896

4. 2022 Prakhar Dutta,Ting-Yu Su,An-Ying Fu,Mei-Chi Chang,Yu-Jie Guo,I-Jung Tsai, Pei-Kuen Wei, Yu-Sheng Chang, Ching-Yu Lin*, and Yu-Jui Fan*. Combining portable solar-powered centrifuge to nanoplamonic sensing chip with smartphone reader for rheumatoid arthritis detection . Chemical Engineering Journal .2022 ;(434):133864-133873

5. 2022 I-Jung Tsai,Wen-Chi Shen,Chia-Ling Lee,Horng-Dar Wang,Ching-Yu Lin. Machine Learning in Prediction of Bladder Cancer on Clinical Laboratory Data . Diagnostics .2022 ;(12):203-219

6. 2022 Horn-Jiunn Sheen,,Bivas Panigrah,Bivas Panigrah,Wei-Chen Hsu,ei-Shan Chung,Qiu-Zhe Xie, Ching-Yu Lin, Yu-Sheng Chang, Chih-Ting Lin, Yu- Jui Fan. Electrochemical biosensor with electrokinetics-assisted molecular trapping for enhancing C-reactive protein detection . Biosensors and Bioelectronics .2022 ;(210):2022-2030

7. 2022 Monika Renuka Sanotra,Wen-Chung Huang,Simon Silver,Ching-Yu Lin,Tsuei-Chuan Chang,Doan Phuong Quy Nguyen, Ching-Kuo Lee, Shu-Huei Kao, Jonathan Chang-Cheng Shieh, Yung-Feng Lin. Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease Clinical Biochemistry . Clinical Biochemistry .2022 ;(101):26-24

8. 2022 I-Jung Tsai,Wen-Chi Shen,Jia-ZhenWu,Yu-Sheng Chang,Ching-Yu Lin. Autoantibodies to Oxidatively Modified Peptide: Potential Clinical Application in Coronary Artery Disease . Diagnostics .2022 ;(12):2269-2287

9. 2022 Chen-Chi Chang, I-Jung Tsai,Wen-Chi Shen,Hung-Yi Chen,Po-Wen Hsu,,Ching-Yu Lin. A Coronary Artery Disease Monitoring Model Built from Clinical Data and Alpha-1-Antichymotrypsin . Diagnostics .2022 ;(12):1415-1434

10. 2022 Yuarn-Jang Lee,Ying-Chin Lin,Chen-Chung Liao,Yu-Sheng Chang,Yu-Hui Huang,I-Jung Tsai, Jin-Hua Chen, Sheng-Hong Lin, Yi-Fang Lin, Ting-Wan Hsieh, Yi-Su Chen, Chih-Yin Wu, Chi-Ching Chang, Ching-Yu Lin. Using anti-malondialdehyde-modified peptide adduct autoantibodies in serum of taiwanese women to diagnose primary Sjogren’s syndrome . Clinical Biochemistry .2022 ;(108):27--41

11. 2021 Ying-Chin Lin,Ching-Yu Lin,Hsiu-Mei Chen,Li-Pin Kuo,Cheng-En Hsieh,Xiang-He Wang,Chih-Wen Cheng,Chih-Yin Wu,Yi-Su Chen. Direct and Label-Free Determination of Human Glycated Hemoglobin Levels Using Bacteriorhodopsin as the Biosensor Transducer . Sensors .2021 ;(20):7274-7288

12. 2021 Kai‑Leun Tsai,Che‑Chang Chang,Yu‑Sheng Chang,Yi‑Ying Lu,I‑Jung Tsai,Jin‑Hua Che,, Sheng‑Hong Lin, Chih‑Chun Tai, Yi‑Fang Lin, Hui‑Wen Chang, Ching‑Yu Lin and Emily Chia‑Yu Su. Isotypes of autoantibodies against novel differential 4‑hydroxy‑2‑nonenal‑modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women . BMC Med Inform Decis Mak .2021 ;(21):49-68

13. 2021 I-Jung Tsai,Emily Chia-Yu Su,I-Lin Tsai,Ching-Yu Lin. Clinical Assay for the Early Detection of Colorectal Cancer Using Mass Spectrometric Wheat Germ Agglutinin Multiple Reaction Monitoring . cancers .2021 ;(13):2190-2205

14. 2021 Yu‐Cheng Hsu,I‐Jung Tsai,Hung Hsu,Po‐Wen Hsu,Ming‐Hui Cheng,Ying‐Li Huang, Jin‐Hua Chen,Meng‐Huan Lei and Ching‐Yu Lin. Using Anti‐Malondialdehyde Modified Peptide Autoantibodies to Import Machine Learning for Predicting Coronary Artery Stenosis in Taiwanese Patients with Coronary Artery Disease . diagnostics .2021 ;(11):961-973

15. 2020 Chih-Hong Pan,Ching-Yu Lin,Ching-Huang Lai,Hueiwang Anna Jeng. Arsenic Exposure and Methylation Eciency in Relation to Oxidative Stress in Semiconductor Workers . Atmosphere .2020 ;(11):464-479

16. 2019 Tsai KL,Liao CC,Chang YS,Huang CW,Huang YC,Chen JH, Lin SH, Tai CC, Lin YF , Lin CY. Low Levels of IgM and IgA Recognizing Acetylated C1-Inhibitor Peptides Are Associated with Systemic Lupus Erythematosus in Taiwanese Women . Molecules .2019 ;(24):1645-1659

17. 2018 Cheng CW,Chang CC, Patria YN,Chang RT, Liu YR,Li FA, Shih HM , Lin CY. Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer . Cancer Medicine .2018 ;(7):64-74

18. 2018 CY Lin,ST Yang,SC Shen,YC, Hsieh,FT Hsu,CY Chen, YH Chiang, JY Chuang, KY Chen, TI Hsu, WC Leong, YK Su, WL Lo, YS Yeh, YN Patria, HM Shih, CC Chang, SY Chou. Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression . Molecular Oncology .2018 ;(12):756-771

19. 2018 Lin CY,Sheu JJ,Tsai IS,Wang ST,Yang LY,IU Hsu, Chang HW, Lee HM, SH Kao, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141-147 in Taiwanese with Alzheimer's disease . Clinical Biochemistry .2018 ;(56):75-82

20. 2018 Cheng CW,Chang CC,Chen HW,Lin CY,Chen JS. Serum ApoA4 levels predicted the progression of renal impairment in T2DM . European Journal of Clinical Investigation .2018 ;(48):e12937-e12937

21. 2018 Liao CC,Chang YS,Cheng CW,Chi WM,Tsai KL,Chen WJ, Kung TS, Tai CC, Lin YF, Lin HT, Lu YY, Lin CY*. Isotypes of autoantibodies against differentially expressed novel malondialdehyde-modified peptide adducts in serum of Taiwanese women with rheumatoid arthritis . Journal of Proteomics .2018 ;(170):141-150

22. 2017 Hsu SH ,Chuang KW ,Chen CS ,Lin CY,Chang CC . Two Interrogated FBG Spectral Linewidth for Strain Sensing through Correlation . Sensors .2017 ;(17):2837-2843

23. 2017 YS Chang,CH Pan,CC Chang,KL Tsai,HW Chou,JH Chen, SH Lin, YY Lu, CC Tai, YF Lin, and CY Lin*. Low Levels of IgG Recognizing the α-1-Antitrypsin Peptide and Its Association with Taiwanese Women with Primary Sjögren's Syndrome . International Journal of Molecular Sciences .2017 ;(18):2750-2762

24. 2016 Chen-Chung Liao,Pei-Lun Chou,Chao-Wen Cheng,Yu-Sheng Chang,Wei-Ming Chi,Kai-Leun Tsai, Wei-Jung Chen, Ting-Shuan Kung, Chih-Chun Tai, Kuan-Wei Lee, You-Chia Chen, and Ching. Comparative analysis of novel autoantibody isotypes against citrullinated-inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3)(542-556) peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren's syndrome and secondary Sjögren's syndrome in rheumatoid arthritis . Journal of Proteomics .2016 ;(141):1-11

25. 2016 SH Hsu,CY Lin,CT Tuan,CC Chang. MicroRNA biosensing through spectral interferometry-based surface plasmon resonance using telecommunication wavelength . ELECTRONICS LETTERS .2016 ;(52):1096-1098

26. 2016 WC Tsai,Z. Zhuang,CY. Lin,WJ Chen. Novel antimicrobial peptides with promising activity against multidrug resistant Salmonella enterica serovar Choleraesuis and its stress response mechanism . J Appl Microbiol .2016 ;(121):952-965

27. 2015 Uen YH, Liao CC,Lin JC,Pan YH,Liu YC,Chen YC,Chen WJ, Tai CC, Lee KW, Liu YR, Lin HT, Lin CY. Analysis of Differentially Expressed Novel Post-Translational Modifications of Plasma Apolipoprotein E in Taiwanese Females with Breast Cancer . J Proteomics .2015 ;(126):252-262

28. 2014 S. H. Hsu,Y.-C. Yang,Y.-H. Su,S.-M. Wang,S.-A. Huang,C.-Y. Lin. Biosensing using microring resonator interferogram . Sensors-Basel .2014 ;(14):1184-1194

29. 2014 Kuo CC,Lin CY,Shih YL,Hsieh CB,Lin PY,Guan SB, Hsieh MS, Lai HC, Chen CJ and Lin YW. Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas . Clin Chem Lab Med .2014 ;(52):1235-1245

30. 2014 Lin JC,Lin CY,Tarn WY,Li FY. Elevated SRPK1 lessens apoptosis in the breast cancer cells through RBM4-regulated splicing events . RNA .2014 ;(20):1621-1631

31. 2014 Tsai WC,Kuo TY,Lin CY,Lin JC,Chen WJ. Photobacterium damselae subsp. piscicida responds to antimicrobial peptides through phage-shock-protein A (PspA)-related extracytoplasmic stress response system . J Appl Microbiol .2014 ;(118):27-38

32. 2013 Yih-Huei Uen,Kai-Yuan Lin,Ding-Ping Sun,Chen-Chung Liao,Ming-Song Hsieh,Yung-Kai Huang, Yen-Wei Chen, Pei-Hsuan Huang, Wei-Jung Chen, Chih-Chun Tai, Ching-Yu Lin. Comparative proteomics, network analysis and post-translational modification identification reveal differential profiles of plasma Con A-bound glycoprotein biomarkers in gastric cancer . Journal of Proteomics .2013 ;(83):197-213

33. 2013 SH Hsu,CY Tsou,MS. Hsieh,CY Lin. Low-coherence interferometric fiber sensor with improved resolution using stepper motor assisted optical ruler . Optical Fiber Technology .2013 ;(19):223-226

34. 2012 LC Chuang,CY Hu,HC Chen,PJ Lin,BH Lee,CY Lin, MH Pan, SL You, CY Hsieh, CJ Chen.. Associations of Human Leukocyte Antigen Class II Genotypes With Human Papillomavirus 18 Infection and Cervical Intraepithelial Neoplasia Risk. . Cancer .2012 ;(1):223-231

35. 2012 Lee-Wen Huang,Ching-Yu Lin,Chin-Cheng Lee,Tsan-Zon Liu,Cherng-Jye Jeng. Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors . Appl Immunohistochem Mol Morphol .2012 ;(20):381-385

36. 2012 Lee-Wen Huang,Yu-Hung Lin,Hun-Shan Pan,Kok-Min Seow,Ching-Yu Lin. Human papillomavirus genotyping as a predictor of high-grade cervical dysplasia in women with mildly cytologic abnormalities: a two-year follow-up report . Diagn Cytopathol .2012 ;(40):673-677

37. 2011 Nae-Fang Twu,Ming-Shyen Yen,Yi-Jen Chen,Hei-Yu Lau,Bill Ken-Jen Yu,Ching-Yu Lin. Type-specific human papillomavirus DNA testing with the genotyping array:a comparison of cervical and vaginal sampling . European Journal of Obstetrics & Gynecology and Reproductive Biology .2011 ;(156):96-100

38. 2011 Hui-Chi Chen,San-Lin You,Chang-Yao Hsieh,Mark Schiffman,Ching-Yu Lin,Mei-Hung Pan, Yi-Chun Chou, Kai-Li Liaw, Ann W. Hsing, Chien-Jen Chen. Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan: A community-based survey of 10602 women . International Journal of Cancer .2011 ;(128):1192-1203

39. 2011 MS Hsieh,TG Wu,CS Su,WJ Cheng,Namik Ozbek,KY Tsai and CY Lin. Comparison of an electrochemical biosensor with optical devices for hemoglobincmeasurement in human whole blood samples . Clinica Chimica Acta .2011 ;(412):2150-2156

40. 2011 HC Chen,Mark Schiffman,CY Lin,MH Pan,SL You,LC Chuang, CY Hsieh, KL Liaw, Ann Hsing, CJ Chen. Persistence of Type-specific Human Papillomavirus Infection and Increased Long-term Risk of Cervical Cancer . Journal of the National Cancer Institute .2011 ;(103):1387-1396

41. 2011 Ya-Ju Chang,Hui-Chi Chen,Bor-Heng Lee,San-Lin You,Ching-Yu Lin,MH Pan, YC Chou, CY Hsieh, YM Chen, YJ Cheng, CJ Chen. Unique variants of human papillomavirus genotypes 52 and 58 and risk of cervical neoplasia . International Journal Cancer .2011 ;(129):965-973

42. 2010 Sing-Chung Li,Ching-Yu Lin,Tzong-Fu Kuo,Yun-Ho Lin,Chia-Chun Chen,Way-Neng Lin, Wing P. Chan. Chicken model of steroid-induced bone marrow adipogenesis using proteome analysis: A preliminary study . Proteome Science .2010 ;(8):47-54

43. 2008 Lin CY,Chao Angel,Chou, HH,Yang YC,Ho CM,Lin RW , Chang TC, Chiou JY, Chao FY, Wang KL, Chi. Human papillomavirus typing with a polymerase chain reaction-based genotyping array compared with type-specific PCR . Journal of Clinical Virology .2008 ;(42):361-367

44. 2008 Ding DC,Hsu HC,Huang RL,Lai HC,Lin CY,Yu MH, Chu TY. Type specific distribution of HPV along the full spectrum of cervical carcinogenesis in Taiwan, an indication of viral oncogenic potential . European Journal of Obstetrics & Gynecology and Reproductive Biology .2008 ;(140):245-251

45. 2008 Guo Ming,Lin CY,Gong Yun,Cogd David E,Zhang Wei,Lin E, Sneige Nour. Human Papillomavirus Genotyping for the Eight Oncogenic Types Can Improve Specificity of HPV Testing in Women with Mildly Abnormal Pap Results . Modern Pathology .2008 ;(21):1037-1043

46. 2007 Lin CY,HC Chen,RW Lin,SL You,CM You,LC Chuang, MH Pan, MH Lee, YC Chou, CJ Chen. Quality Assurance of Genotyping Array for Detection and Typing of Human Papillomavirus . Journal of Virological Methods .2007 ;(140):1-9

研究計畫

計畫名稱
112 糖尿病的心血管風險:新穎性抗丙二醛修飾胜肽加成物自體抗體在血漿中的致病角色並導入機器學習以預測第二型糖尿病合併冠狀動脈疾病
補助單位
國家科學及技術委員會

計畫名稱
110 111年度【產學合作計畫-使用麥胚凝集素-多重反應監測質譜試劑進行大腸直腸癌早期檢測的臨床分析: U.S. FDA的規範】
補助單位
國家科學及技術委員會

計畫名稱
110 111年度科技部產學-使用麥胚凝集素-多重反應監測質譜試劑進行大腸直腸癌 早期檢測的臨床分析: U.S. FDA的規範
補助單位
昕穎生醫技術股份有限公司

計畫名稱
108 開發肺癌檢測血液DNA甲基化生物標記之專利地圖分析---以USPTO/TW/EPO/WIPO資料庫為例
補助單位
科技部

計畫名稱
108 開發類風濕關節炎自體免疫疾病檢測之生物標記研究計畫
補助單位
天亮醫療器材股份有限公司園區分公司

計畫名稱
107 新穎性關節液與血清蛋白質之氨甲醯修飾與抗氨甲醯修飾蛋白質的自體抗體在類風濕性關節炎臨床關聯性角色的探討
補助單位
科技部

計畫名稱
106 人類抗瓜氨酸-α-間胰蛋白抑制劑重鏈H3胜肽抗體酵素免疫分析試劑:檢測自體免疫風濕性疾病的體外診斷試劑
補助單位
科技部

計畫名稱
106 人類抗瓜氨酸-α-間胰蛋白抑制劑重鏈H3胜肽抗體酵素免疫分析試劑:檢測自體免疫風濕性疾病的體外診斷試劑
補助單位
昕創生醫技術股份有限公司

計畫名稱
105 新穎性血清蛋白質轉譯後修飾對類風濕關節炎、修格連氏症候群、全身性紅斑性狼瘡及其合併症致病角色的探討:丙二醛修飾的研究
補助單位

計畫名稱
104 新穎性關節液與血清蛋白質轉譯後修飾對類風濕關節炎、修格連氏症候群、全身性紅斑性狼瘡及其合併症致病角色的探討: 4-羥基-2-壬烯醛修飾的研究
補助單位
科技部

計畫名稱
103 新穎性關節液與血清蛋白質之丙二醛修飾在類風濕關節炎致病角色之探討
補助單位
科技部

計畫名稱
102 產學合作計畫-以質譜選擇反應偵測模式發展肺癌早期檢測之血漿CON-A補捉轉捉轉訪後修飾胜肽生物標記的開發計畫
補助單位
科技部

計畫名稱
102 產學合作計畫-以質譜選擇反應偵測模式發展肺癌早期檢測之血漿CON-A補捉轉捉轉訪後修飾胜肽生物標記的開發計畫-昕穎
補助單位
昕穎生醫技術股份有限公司

計畫名稱
101 血漿N-醣蛋白質轉譯後修飾在類風濕性關節炎合併修格連氏症候群致病角色之探討
補助單位
行政院國家科學委員會

計畫名稱
101 級聯干涉與共振器線寬之高靈敏矽線波導生醫光電感測
補助單位
臺灣科技大學

計畫名稱
100 以質譜選擇反應偵測模式發展胃癌早期檢測之血漿Con-A捕捉轉譯後修飾胜肽生物標記的開發計畫
補助單位
行政院國家科學委員會

計畫名稱
100 以質譜選擇反應偵測模式發展胃癌早期檢測之血漿Con-A捕捉轉譯後修飾胜肽生物標記的開發計畫
補助單位
昕穎生醫技術股份有限公司

計畫名稱
98 卵巢癌中葡萄糖調控蛋白78(GRP78)之表現
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
96 加護病房敗血症患者生物標記診斷
補助單位
臺北醫學大學附設醫院

計畫名稱
96 人類乳突瘤病毒與乳癌相關性證據的評估
補助單位
臺北醫學大學新聘教師計畫