| 1. |
2024
Adi Yugatama,Ya-Lin Huang,Ming-Jen Hsu,Jia-Pei Lin,Fang-Ching Chao,Jenny KW Lam, Chien-Ming Hsieh.
Oral Delivery of Photopolymerizable Nanogels Loaded with Gemcitabine for Pancreatic Cancer Therapy: Formulation Design, and in vitro and in vivo Evaluations
. International Journal of Nanomedicine
.2024
;(19):3753-3772
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| 2. |
2023
Huang YH,Chen HK,Hsu YF,Chen HC,Chuang CH,Huang SW, Hsu MJ.
Src-FAK Signaling Mediates Interleukin 6-Induced HCT116 Colorectal Cancer Epithelial–Mesenchymal Transition
. International Journal of Molecular Sciences
.2023
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| 3. |
2023
Athika Darumas Putri,Hsu MJ,Han CL,Chao FC,Hsu CH,Lorenz C.D, Hsieh CM.
Differential cellular responses to FDA-approved nanomedicines: an exploration of albumin-based nanocarriers and liposomes in protein corona formation
. Nanoscale
.2023
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| 4. |
2023
Chang HW,Hsu MJ,Chien LN,Chi NF,Yu MC,Chen HC, Lin YF, Hu CJ.
Role of the Autism Risk Gene Shank3 in the Development of Atherosclerosis: Insights from Big Data and Mechanistic Analyses
. Cells
.2023
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| 5. |
2023
Huang SW, Hsu MJ, Chen HC, Meleddu R, Distito S., Maccioni E., Cottiglia F..
Suppression of Lipopolysaccharide-Induced COX-2 Expression via p38MAPK, JNK, and C/EBPβ Phosphorylation Inhibition by Furomagydarin A, a Benzofuran Glycoside from Magydaris pastinacea
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2023
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| 6. |
2022
Hsu MJ,Chen HK,Lien JC,Huang YH,Huang SW.
Suppressing VEGF-A/VEGFR-2 Signaling Contributes to the Anti-Angiogenic Effects of PPE8, a Novel Naphthoquinone-Based Compound
. cells
.2022
;(11):1-17
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| 7. |
2022
Hsu MJ,Chen HK,Chen CY,Lien JC,Gao JY,Huang YH, Hsu Justin BK, Lee Gilbert A, Huang SW.
Anti-Angiogenetic and Anti-Lymphangiogenic Effects of a Novel 2-Aminobenzimidazole Derivative, MFB
. Frontiers in Oncology
.2022
;(12)
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| 8. |
2020
Huang SW, Chyuan IT,Shiue C,Yu MC,Hsu YF,Hsu MJ.
Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signaling cascade
. Journal of Cellular and Molecular Medicine
.2020
;(2):1822-1836
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| 9. |
2019
Lien JC,Chung CL,Huang TF,Chang TC,Chen KC,,Gao GY, Hsu MJ, Huang SW.
A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐angiogenesis effects by targeting VEGFR‐2 signalling
. British Journal of Pharmacology
.2019
;(17):4034-4049
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| 10. |
2019
Huang SW,Yang HY,Huang WJ,Chen WC,Yu MC,Wang SW, Hsu YF, Hsu MJ.
WMJ-S-001, a novel aliphatic hydroxamate-based compound, suppresses lymphangiogenesis through p38MAPK-p53-survivin signaling cascade
. Frontiers in Oncology
.2019
;(9):1188-1204
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| 11. |
2018
Yen CS,Choy CS,Huang WJ,Huang SW,Lai PY,Yu MJ, Shiue C, Hsu YF, Hsu MJ.
A Novel Hydroxamate-Based Compound WMJ-J-09 Causes Head and Neck Squamous Cell Carcinoma Cell Death via LKB1-AMPK-p38MAPK-p63-Survivin Cascade
. Frontiers in Pharmacology
.2018
;(9):167
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| 12. |
2018
Sheu JR,Chen ZC,Hsu MJ,Wang SH ,Jung KW,Wu WF, Pan SH, Teng RD, Yang CH, Hsieh CY.
CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation
. Journal of Cellular and Molecular Medicine
.2018
;(22):999-1013
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| 13. |
2017
Chang Y ,Li JY ,Jayakumar Thanasekaran ,Hung SH,Lee WC,Manubolu M, Sheu JR, Hsu MJ.
Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition
. International Journal of Molecular Sciences
.2017
;(18):E2545
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| 14. |
2017
Chuang YF,Huang SW,Hsu YF,Yu MC,Ou G.,Huang WJ, Hsu MJ.
WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade
. British Journal of Pharmacology
.2017
;(174):2941-2961
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| 15. |
2016
Yen CS,Chen JC,Chang YF,Hsu YF,Chiu PT,Shiue C, Chuang YF, Ou G, Hsu MJ.
Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade
. Scientific Reports
.2016
;(6):25082
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| 16. |
2016
Huang YH,Yang HY,Huang SW,Ou G,Hsu YF,Hsu MJ.
Interleukin-6 Induces Vascular EndothelialGrowth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells
. PlosOne
.2016
;(11):e01588
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| 17. |
2016
Yen TL,Chen RJ,Jayakumar T,Lu WJ,Hsieh CY,Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR.
Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats
. Translational Research
.2016
;(170):57-72
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| 18. |
2016
Lin RK,Lin YF,Hsu MJ,Hsieh CL,Wang CY,HuangCC, Huang WJ.
Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species
. Bioorganic and Medicinal Chemistry Letters
.2016
;(26):5528-5533
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| 19. |
2015
Chang YF,Hsu YF,Chiu PT,Huang WJ,Huang SW,Ou G, Sheu JR, Hsu MJ.
WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain-containing protein tyrosine phosphatase 1
. Oncotarget
.2015
;(6):85-100
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| 20. |
2015
Chen WC,Yen CS,Huang WJ,Hsu YF,Ou G,Hsu MJ.
WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in lipopolysaccharide-stimulated RAW264.7 macrophages
. British Journal of Pharmacology
.2015
;(172):1894-1908
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| 21. |
2015
Chuang YF,Chen MC,Huang SW,Hsu YF,Ou G,Tsai YJ, Hsu MJ.
Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells
. PLoS One
.2015
;(10):1-20
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| 22. |
2015
Huang YH,Huang SW,Hsu YF,Ou G,Huang WJ,Hsu MJ.
The effects of a novel aliphatic chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death
. Scientific Reports
.2015
;(5):15900
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| 23. |
2015
Yang PS,Wang MJ,Jayakumar T,Chou DS,Ko CY,Hsu MJ, Hsieh CY.
Antiproliferative Activity of Hinokitiol, a Tropolone Derivative,Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells
. molecules
.2015
;(20):8198-8212
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| 24. |
2014
Huang YH,Yang HY,Hsu YF,Chiu PT,Ou G,Hsu MJ.
Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells.
. Angiogenesis
.2014
;(17):407-418
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| 25. |
2014
Chuang YF,Yang HY,Ko TL,Hsu YF,Sheu JR,Ou G, Hsu MJ.
Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells.
. Biochem Pharmacol.
.2014
;(88):372-383
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| 26. |
2014
Chen YY,Hsieh CY,Jayakumar T,Lin KH,Chou DS,Lu WJ, Hsu MJ, Sheu JR.
Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade
. Scientific Reports
.2014
;(4):5651-5662
|
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| 27. |
2014
Hsieh CY,Hsiao G,Hsu MJ,Wang YH,Sheu JR.
PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells.
. J Cell Mol Med
.2014
;(18):1278-1289
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| 28. |
2013
Chen YY,Hsu MJ,Sheu JR,Lee LW,Hsieh CY.
Andrographolide, a Novel NF- κ B Inhibitor, Induces Vascular Smooth Muscle Cell Apoptosis via a Ceramide-p47phox-ROS Signaling Cascade.
. Evid Based Complement Alternat Med
.2013
;(2013):821813
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| 29. |
2013
Yang HY,Hsu YF,Chiu PT,Ho SJ,Wang CH,Chi CC, Huang YH, Lee CF, Li YS, Ou, G, Hsu MJ.
Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: Targeting vascular endothelial growth factor receptor signaling and angiogenesis.
. PLoS One
.2013
;(8):e81592
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| 30. |
2013
Weng HY,Hsu MJ,Chen CC,Chen BC,Hong CY,Teng, CM, Pan, SL, Chiu, WT, Lin, CH.
Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade
. Eur J Pharmacol.
.2013
;(698):103-109
|
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| 31. |
2013
Chang HL,Chen CY,Hsu YF,Kuo WS,Ou G,Chiu PT, Huang YH, Hsu MJ.
Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade
. BBA-General Subjects
.2013
;(1830):4053-4064
|
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| 32. |
2012
Hsu YF,Sheu JR,Lin CH,Yang DS,Hsiao George,Ou George, Chiu PT, Huang YH, Kuo WS, Hsu MJ.
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.
. Biochim Biophys Acta-Gen. Subjects
.2012
;(1820):104-115
|
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| 33. |
2012
Lu WJ,Lin KH,Hsu MJ,Chou DS,Hsiao G,Sheu JR.
Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade
. Biochem Pharmacol
.2012
;(84):914-924
|
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| 34. |
2012
Ko WC,Chen BC,Hsu MJ,Tsai CT,Hong CY,Lin CH.
Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway
. Acta Pharmacol Sin.
.2012
;(33):49-56
|
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| 35. |
2012
Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC, Chiu, WT, Lin, CH.
Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
. J Biomed Sci.
.2012
;(19):86
|
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| 36. |
2011
Hsieh CY,Hsu MJ,Hsiao George,Wang YH,Huang CH,Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu JR.
ANDROGRAPHOLIDE ENHANCES NF-κB SUBUNIT P65 SER536 DEPHOSPHORYLATION THROUGH ACTIVATION OF PROTEIN PHOSPHATASE 2A (PP2A) IN VASCULAR SMOOTH MUSCLE CELLS
. J. Biol. Chem
.2011
;(286):5942-5955
|
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| 37. |
2011
Hsu YF,Sheu JR,Hsiao George,Lin CH,Chang TH,Chiu PT, Wang TY, Hsu MJ.
p53 in trichostatin A induced C6 glioma cell death
. BBA-Gen Subjects
.2011
;(1810):504-513
|
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| 38. |
2011
Hsu WH,Yang HY,Chiu PT,Hsu MJ.
Molecular Mechanisms in Lipopolysaccharide-Induced Interleukin 6 Release in Lymphatic Endothelial Cells
. Journal of Food and Drug Analysis
.2011
;(19):245-251
|
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| 39. |
2011
Jang TN,Chiu PT,Chen WC,Hsu MJ.
Molecular Mechanisms in Peptidoglycan-induced Human Umbilical Vascular Endothelial Cell Apoptosis
. Journal of Food and Drug Analysis
.2011
;(19):159-166
|
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| 40. |
2011
Hsu YF,Sheu JR,Lin CH,Chen WC,Hsiao G,Ou G, Chiu PT, Hsu MJ.
MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide
. Biochimica et Biophysica Acta
.2011
;(1810):1160-1169
|
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| 41. |
2010
Hsu MJ,Sheu JR,Lin CH,Shen MY,Hsu CY.
Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration
. Biochim Biophys Acta
.2010
;(1800):290-296
|
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| 42. |
2010
Hsu MJ,Chang CK,Chen MC,Chen BC,Ma HP,Hong CY, Lin CH.
Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages
. Journal of Leukocyte Biology
.2010
;(87):1069-1082
|
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| 43. |
2009
Chen BC,Kang JC,Lu YT,Hsu MJ,Liao CC,Chiu WT, Yeh FL, Lin CH.
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway.
. Mol Immunol
.2009
;(46):1179-1188
|
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| 44. |
2009
Kuo CT,Chen BC,Yu CC,Weng CM,Hsu MJ,Chen CC, Chen MC, Teng CM, Pan SL, Bien MY, Shih CH, Lin CH.
Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells.
. J Biomed Sci
.2009
;(1):16-43
|
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| 45. |
2009
Yu CC,Hsu MJ,Kuo ML,Chen RF,Chen MC,Bai KJ, Yu MC, Chen BC, Lin CH.
Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway.
. J Immunol.
.2009
;(182):7916-7927
|
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| 46. |
2009
Chen BC,Chang HM,Hsu MJ,Shih CM,Chiu YH,Chiu WT, Lin CH.
Peptidoglycan induces cyclooxygense-2 expression in macrophages by activating the neutral sphingomyelinase-ceramide pathway.
. J. Biol. Chem
.2009
;(284):20562-20573
|
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| 47. |
2008
Kuo CT,Hsu MJ,Chen BC,Chen CC,Teng CM,Pan SL, Lin CH.
Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction
. Toxicology Letters
.2008
;(177):48-58
|
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| 48. |
2007
Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ, Chen BC.
Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells.
. Eur. J. Pharmacol.
.2007
;(560):101-109
|
|
| 49. |
2007
Hsu MJ,Hsu CY,Chen BC,Chen MJ,Ou Geprge,Lin CH.
ASK1 in Amyloid β Peptide-Induced Cerebral Endothelial Cell Apoptosis
. J. Neurosci.
.2007
;(27):5719-5729
|
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| 50. |
2006
Chen BC,Liao CC,Hsu MJ,Liao YT,Lin CC,Sheu JR, Lin CH.
Peptidoglycan-Induced IL-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, PGE2/PGE4 Receptors, Protein Kinase A, I kappaB Kinase, and NF- kappaB.
. J. Immunol
.2006
;(177):681-693
|
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| 51. |
2006
Lin CH,Cheng HW,Hsu MJ,Chen MC,Lin CC,Chen BC.
c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells.
. J. Immunol.
.2006
;(177):3427-3438
|
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| 52. |
2005
Hsu MJ,Chao Y,Chang YH,Ho FM,Huang LH,Huang YL, Luh TY, Chen C., Lin, WW.
Cell apoptosis induced by a synthetic carbazole compound LCY-2-CHO is mediated through activation of caspase and mitochondrial pathways.
. Biochem. Pharmacol.
.2005
;(70):102-112
|
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| 53. |
2004
Chen BC,Chang YS,Kang JC,Hsu MJ,Sheu JR,Chen TL, Teng CM, Lin CH.
Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages.
. J. Biol. Chem.
.2004
;(279):20889-20897
|
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| 54. |
2004
Chen BC,Yu CC,Lei HC,Chang MS,Hsu MJ,Huang CL, Chen MC, Sheu JR, Chen TF etc.
Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells.
. J. Immunol.
.2004
;(173):5219-5228
|
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| 55. |
2004
Hsu MJ,Lin WW,Tsao WC,Hsu TL,Chang YC,Hsiao HW,Chiu AW,Chio CC, Hsieh SL.
Enhanced Adhesion of Monocyte via Reverse Signaling Triggered by Decoy Receptor 3 (DcR3)
. Exp. Cell Res
.2004
|
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