郭泰志(Kuo, Tai-Chih) 副教授

Email
tckuo@tmu.edu.tw
現   職
生物化學暨細胞分子生物學科 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
University of Texas at Austin植物系 博士
1991/08/01~1998/07/01
陽明醫學大學生化所 碩士
1986/09/01~1988/06/01
國立臺灣大學植物病蟲害學系 學士
1980/08/01~1984/06/01

本校學術經歷

任職單位與職稱[起迄時間]
生物化學暨細胞分子生物學科副教授
2014/08/01~
生化學科副教授
2012/08/01~2014/07/31
生化學科助理教授
2005/09/07~2012/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學科學研究所助理教授
2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
工業技術研究院生物醫學工程中心研究員
2002/01/01~2005/09/07
Somagenic Inc. (santa Cruz, CA.USA)研究員
2000/05/01~2001/12/01
美國普林斯頓大學博士後研究員
1998/08/01~2000/05/01

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2021 Lee KY,Kuo TC,Chou CM,Dai JZ,Wu SM,Lin CW. Upregulation of CD109 Promotes the Epithelial-to-Mesenchymal Transition and Stemness Properties of Lung Adenocarcinomas via Activation of the Hippo-YAP Signaling . Cells .2021 ;(10)

2. 2021 Tsai TH,Yang CC,Kuo TC,Yang CE,Dai JZ,Chen CL, Lin CW. Overexpression of GLUT3 promotes metastasis of triple‐negative breast cancer by modulating the inflammatory tumor microenvironment . Journal of Cellular Physiology .2021 ;(10)

3. 2021 Chih-Chin Kao,San-Yuan Wang,Yung-Kun Chuang,Wei-Yuan Lee,Wei-Chiao Chang,Mai-SzuWu, Tai-Chih Kuo, I-Lin Tsai. Clinical mass spectrometry discovered human IgG sialylation as a potential biosignature for kidney function . J Pers Med .2021 ;(11):761-772

4. 2021 Chen CY,Chiang YC,Kuo TC,Tam KW,Loh EW. Effects of intranasal oxytocin in food intake and craving: A meta-analysis of clinical trials . Clin Nutr .2021 ;(40):5407-5416

5. 2021 Kuo TC,Lin CC,Tsai CC,Chen SJ,Hung TM,Hsieh CC, Lu JY, Huang RN. Toxicity of Terahertz-Based Functional Mineral Water (Plant-Derived) to Immature Stages of Mosquito Vectors . Insects .2021

6. 2020 Wen-Jing Hsu,Mei-Hsiang Lin, Tai-Chi Kuo,Chi h -Ming Chou,Fwu-Long Mi, ,Chia - Hsiung Cheng, Cheng -Wei Lin. Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells . International Journal of Biological Macromolecules .2020 ;(149):600-608

7. 2020 Tai-Chih Kuo,Meng-Wei Wu,Wei-Chen Lin,Daumantas Matulis,Yuh-Shyong Yang,Si-Yu Li, Wen-Yih Chen. Reduction of interstrand charge repulsion of DNA duplexes by salts and by neutral phosphotriesters - Contrary effects for harnessing duplex formation . Journal of the Taiwan Institute of Chemical Engineers .2020 ;(in press)

8. 2020 Chi Lin,Tai-Chih Kuo,Jin-Chi Lin,Yi-Cheng Ho,Fwu-Long Mi. Delivery of polysaccharides fromOphiopogon japonicus (OJPs) using OJPs/ chitosan/whey protein co-assembled nanoparticles to treat defective intestinal epithelial tight junction barrier . International Journal of Biological Macromolecules .2020 ;(160):558-570

9. 2020 Tsung-Min Lee,El-Wui Loh,Tai-Chih Kuo,Ka-Wai Tam,Hsin-Chien Lee, Dean Wu. Effects of Ultraviolet and Blue-light filtering on Sleep: A Meta-analysis of Controlled Trials and Studies on Cataract Patients . Eye .2020

10. 2020 Kuo-Hao Ho,Tai-Chih Kuo,Yi-Ting Lee,Peng-Hsu Chen,Chwen-Ming Shih,Chia-Hsiung Cheng, Ann-Jeng Liu, Chin-Cheng Lee, Ku-Chung Chen. Xanthohumol regulates miR-4749-5p-inhibited RFC2 signaling in enhancing temozolomide cytotoxicity to glioblastoma . Life Sciences .2020 ;(254):117807

11. 2020 Jing-Ya Shiao,Yu-Ting Chang,Ming-Chu Chang,Michael X Chen,Li-Wei Liu,Xiang-Yu Wang, Yun-Jung Tsai, Tai-Chih Kuo, I-Lin Tsai. Development of efficient on-bead protein elution process coupled to ultra-high performance liquid chromatography-tandem mass spectrometry to determine immunoglobulin G subclass and glycosylation for discovery of bio-signatures in pancreatic disease . J. Chrom A .2020 ;(1621):461039

12. 2019 Baranauskiene L.,Kuo TC,Chen WY,Matulis D. Isothermal titration calorimetry for characterization of recombinant proteins . Current Opinion in Biotechnology .2019 ;(55):9-15

13. 2019 Tai-Chih Kuo,Ting-Jou Ding,Jui-Hui Lin,Shih-Hsin Ma. Optical Design of an LED Lighting Source for Fluorescence Microscopes . Appl. Sci. .2019 ;(9)

14. 2018 Lue JH,Su YS,Kuo TC. Workshop, Cost-Effective and Streamlined Fabrications of Re-Usable World-To-Chip Connectors for Handling Sample of Limited Volume and for Assembling Chip Array . Sensors .2018 ;(18):4223-4228

15. 2018 Kuo TC,Huang YC,Matulis D,Chen WY. Molecular self-interactions of ribonuclease A revealed by isothermal titration calorimetry and self-interaction chromatography –Effects of anisotropy of protein surface charges . Journal of the Taiwan Institute of Chemical Engineers .2018

16. 2016 Liao HZ,Kuo TC,Kao CH,Chou TM,Kao YH,Huang RN. Identification of the chitinase genes from the diamondback moth, Plutella xylostella . Bulletin of Entomological Research .2016 ;(106):769-780

17. 2015 Tai-Chih Kuo,Ching-Wei Tsai,Peng-Chen Lee,Wen-Yih Chen. Revisiting the Streptavidin-Biotin binding by Using an Aptamer and Displacement Isothermal Calorimetry Titration . J. Mol. Recog. .2015 ;(28):125-128

18. 2013 Kuo TC,Lee PC,Tsai CW,Chen WY. Salt Bridge Exchange Binding Mechanism Between Streptavidin and its DNA Aptamer –Thermodynamics and Spectroscopic Evidences. . J Molecular Recognition .2013 ;(26):149-159

19. 2012 Hu WP,Huang LY,Kuo TC,Hu WW,Chang Y,Chen WY. Optimization of DNA Directed Immobilization on Mixed oligo (ethylene glycol) (OEG) Monolayers for Immunodetectio . Anal Biochem .2012 ;(423):26-35

20. 2012 Kuo TC,,Wang CH,Lin HC,Lin YH,Lin M,Lin CM, Kuo HS. Assessment of Renal Function by the Stable Oxygen and Hydrogen Isotopes in Human Blood Plasma . PLoS One .2012 ;(7):e32137-45

21. 2012 YY Chagn,TC Kuo,CH Hsu,DR Hou,YH Kao,RN Huang. Characterization of the role of protein–cysteine residues in the binding with sodium arsenite. . Arch Toxicol .2012 ;(86):911-922

22. 2012 Tsai MC,Wu JY,Lin HC,Chen TH,Hsieh YH,,Shih CM, Chen WY, Huang RN, Kuo TC. Use of a kinesin-cro fusion protein as the nanoshuttle to transport specific DNA . current nano science .2012 ;(8):669-675

23. 2012 LC Lai,TC Kuo,RN Huang,WJ Wu. The Insecticidal Activities of Fire Ant (Hymenoptera: Formicidae) Venoms against Plutella xylostella (Lepidoptera: Plutellidae) Larvae. . J. Econ. Entomol. .2012 ;(105):1591-1596

24. 2012 Kuo TC,Hsu TC,Liu YC,Yang KH. Size-controllable synthesis of surface-enhanced Raman scattering-active gold nanoparticles coated on TiO2 . Analyst .2012 ;(137):3847-3853

25. 2011 Yu-Ying Chang,Ming-Chang Chiang,Tai-Chih Kuo,Li-Ling Chi,Yung-Hsi Kao,Rong-Nan Huang. The down-regulation of galectin-1 expression is a specific biomarker of arsenic . Toxicology Letters .2011 ;(205):38-46

26. 2010 Lin HL,Lin CC,Lin YJ,Lin HC,Shih CM,Kuo TC. The determination of growth rates of micro organisms by using the optical density data of liquid cultures – a revisit with the relative density approach . Applied & Enviromental Microbiology .2010 ;(76):1683-1685

27. 2009 Wang SH,Shih YL,Kuo TC,Ko WC,Shih CM. Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells . Toxicological Sciences .2009 ;(108):124-131

28. 2008 Dallas A,Balastkaya SV,Kuo TC,Ilves H,Vlassov V,Kaspar RL, Kisich KO, Kazakov SA, Johnston BH. Hairpin ribozyme-antisense RNA constructs can act as molecular lassos . Nucleic Acids Research .2008 ;(36):1-15

29. 2007 Tai-Chih Kuo. Simulation of complex SELEX experiements with a novel statistical model . Computers and Chemical Engineering .2007 ;(31):1007-1019

30. 2006 Kuo TC,Odom OW,Herrin DL. Unusual metal specificity and structure of the group I ribozyme of Chlamydomonas reinhardtii 23S rRNA . FEBS Journal .2006 ;(273):2631-2644

31. 2005 Tai-Chih Kuo. Streamlined method for purifying single-stranded DNA from PCR products for frequent or high-throughput needs . Biotechniques .2005 ;(38):702-704

32. 2000 Laura Landweber,Tai-Chih Kuo,Edward A Curtis. Evolution and assembly of an extremely scrambled gene . Proc. Nat'l Acad Sci, USA .2000 ;(97):3298-3303

研究計畫

計畫名稱
107 闡明動力素分子馬達蛋白質(kinesin molecular motor protein) 之關節區團 (hinge domain)的結構和功能—為建構實用的動力素分子載具鋪路
補助單位
科技部

計畫名稱
107 利用生物物理及生化方法探討新穎寡鍊磷酸甲基化核酸nDNA與互補寡鍊核酸形成的雙股螺旋之特性
補助單位
科技部

計畫名稱
106 利用核酸核適體建構實用蛋白質動力素分子馬達載具
補助單位
科技部

計畫名稱
101 利用基因工程與核酸核適體來建構實用的分子馬達載具-整合經濟有效的顯微鏡影像系統及微流道晶片製造的基礎
補助單位
行政院國家科學委員會

計畫名稱
99 利用蛋白質與核酸工程技術解決發展蛋白分子馬達載具之瓶頸問題
補助單位
行政院國家科學委員會

計畫名稱
98 異常抗藥性微生物多方雙向傳呼之研究
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
96 利用蛋白質動力素分子馬達及核酸適核體aptamers來建構新穎性生醫分子檢測元件
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
96 利用動力素蛋白質馬達與雙價性DNA aptamer來達到在微流道中單方向地運輸特定分子的目的 (III)
補助單位
行政院國家科學委員會

計畫名稱
96 利用蛋白質動力素分子馬達及核酸適核體來建構新穎性生醫分子檢測元件(I)
補助單位
行政院國家科學委員會

計畫名稱
95 篩選並運用能與血清白蛋白及藥物結合的單股DNA aptamers來延長水溶性短效藥物在體內的作用時間
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
95 利用動力素蛋白質馬達與雙價性DNA aptamer來達到在微流道中單方向地運輸特定分子的目的(II)
補助單位
行政院國家科學委員會

計畫名稱
94 利用動力素蛋白質馬達與雙價性DNA aptamer來達到在微流道中單方向地運輸特定分子的目的
補助單位
行政院國家科學委員會

計畫名稱
94 篩選貝塔糊蛋白前驅物、動力素及微小管的DNA aptamers以作為後續探討阿茲海默症病因的分子工具
補助單位
臺北醫學大學新聘教師計畫