林美香(Lin, Mei-Hsiang) 副教授

Email
mhl00001@tmu.edu.tw
現   職
藥物科學學科 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立臺灣大學藥理學研究所 博士
1998/09/01~2003/06/30
國立臺灣大學醫學院藥研所 碩士
1991/09/01~1993/06/01
臺北醫學大學藥學系 學士
1990/09/01~1991/06/01

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科副教授
2012/08/01~
藥物科學學科助理教授
2012/02/01~2012/07/31
藥學系助理教授
2007/08/01~2012/01/31
生化學科助理教授
2004/02/01~2007/07/31
生化學科講師
1998/08/01~2004/01/31
生化學科助教
1995/03/01~1998/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥物科學學科主任
2016/08/01 ~ 2019/07/31
生化學科助理教授
2007/08/01 ~
醫學科學研究所助理教授
2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
臺灣大學助理
2003/09/01~1994/01/31
私立臺北醫學院附設醫院藥師
1994/02/01~1995/02/28

專長與研究領域

學門領域
藥物化學、有機合成
藥學
學術專長
有機化學實驗操作
IR. GC操作

論文著作

清冊下載


1. 2023 Chiu PF ,Lin IC,Lu YL,Chang CN, Chan HY,Lin TS, Tsai KC, Hsieh YSY, Chen MJ, Lin MH*, Liang PH*. Design, structure–activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin–based sulfamates as steroid sulfatase inhibitors . Bioorganic Chemistry .2023 ;(138):106581-106581

2. 2022 Kan TC,Lin MH,Cheng CC ,Lu JW,Sheu MT,Ho YS, Sri Ra-hayu, and Chang JS. Preclinical therapeutic assessment of a new chemotherapeutics [dichloro(4,4'-bis(2,2,3,3-tetrafluoropropoxy)methyl)-2,2'-bi-pryridine) platinum] in an orthotopic patient-derived xenograft 4 model of triple negative breast cancers . Pharmaceutics .2022 ;(14):839-839

3. 2022 Chang CN,Lin IC,Lin TS,Chiu PF,Lu YL,Manmath Narwane, Liu IC, Hng Y, Tsai KC, Lin MH, Hsieh YSY, Chen MJ, Liang PH . The Design, Structure–Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitors . Bioorganic Chemistry .2022 ;(129):106148-106148

4. 2020 Samir Mehndiratta,Lin MH,Yi-Wen Wu,Chun-Han Chen,Tung-Yun Wu,Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP . N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PDL-1 expression . European Journal of Medicinal Chemistry .2020 ;(185,):111725-111725

5. 2020 Hsu WJ ,Lin MH,Kuo TC ,Chou CM ,Mi FL ,Cheng CH, Lin CW. Fucoidan from Laminaria japonica exerts antitumor effect on angiogenesis and micrometastasis in triple-negative breast cancer in vitro and zebrafish model in vivo . International journal of biological macromolecules .2020 ;(149):600-608

6. 2020 Lee JF ,Chang TY ,Liu ZF,Lee NZ,Yeh YH ,Chen YS, Chen TC , Chou HS, Li TK, Lee SB*, Lin MH*. Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases . European Journal of Medicinal Chemistry .2020

7. 2020 Wang SW ,Lin MH ,Hsu FC ,Chen MC , Liou JP ,Liu YT, Chen SS, Lee HY*. Synthesis and biological evaluation of 2-quinolineacrylamides . Bioorg. Med. Chem. .2020 ;(28):115250-115250

8. 2020 Hng Y ,Lin MH ,Lin TS,Lu YL,Chang CN,Liu IC, Tsai KC, Liang PH*. Design and Synthesis of 3-Benzylaminocoumarin-7-O-Sulfamate Derivatives as Steroid Sulfatase Inhibitors . Bioorganic Chemistry .2020

9. 2020 Tseng HJ,Lin MH,Shiao YJ,Yang YC,Chu JC,Chen CY, Chen YY, Lin TE, Su CJ, Pan SL, Chen LC, Wang CY, Hsu KC, Huang WJ*. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease . European Journal of Medicinal Chemistry .2020 ;(192)

10. 2019 Lai MJ,Ojha R,Lin MH,Liu YM,Lee HY,Hsu KC, Chang CY, Chen MC, Nepali, K, Chang JY, Liou JP. 1-Arylsulfonyl Indoline-Benzamides as a New Antitubulin Agents, with Inhibition of Histone Deacetylase . European Journal of Medicinal Chemistry .2019 ;(162):612-630

11. 2019 Lin MH,Zheng JH ,Wang JH ,Hsieh YC,Cho EC.. NO2 functionalized coumarin derivatives suppress cancer progression and facilitate apoptotic cell death in KRAS mutant colon cancer . Chemico-Biological Interactions .2019 ;(309):1-10

12. 2019 Kunal Nepali,Lin MH,Chao MW,Peng SJ,Hsu KC,Lin Tony Eight, Chen MC, Lai MJ, Pan SL, Liou JP. Amide-Tethered Quinoline-Resorcinol Conjugates as a new class of HSP90 Inhibitors Suppressing the Growth of Prostate Cancer cells . Bioorganic Chemistry .2019 ;( 91):103119-103119

13. 2018 Tseng SH,Chang TY,Shih CK,Hsieh RH,Chen CW,Chen YC, Lin MH, Chang JS. Effect of Endoplasmic Reticular Stress on Free Hemoglobin Metabolism and Liver injury . Int. J. Mol. Sci. .2018 ;(19):1977

14. 2017 Wu YL,Xie J,An SW,Oliver N,Barrezueta NX,Lin MH, Birnbaume L, Huang CL. Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho . kidney international .2017 ;(91):830-840

15. 2017 Lin HC,Lin MH,Liauo JH,Wu TH,Lee TH,Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW. Antroquinonol, a Ubiquinone Derivative from the Mushroom . Journal of Agricultural and Food Chemistry .2017 ;(65):51-59

16. 2016 Chiang LL,Tseng IJ,Lin PY,Sheu SY,Lin CT,Hsieh YH, Lin YJ, Chen HL, and Lin MH. Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects . molecules .2016 ;(21):100-100

17. 2015 Tseng IJ,Lin PY,Sheu SY,Tung WN,Lin CT,Lin MH. Characterization of Novel Aminobenzylcantharidinimides and Related Imides by Proton NMR Spectra and Their Effects on NO Induction . Journal of the Chinese Chemical Society .2015 ;(62):59-63

18. 2014 Huang YH,Lin MH,Wang PC,Wu YC,Chiang HL,Wang YL, Chang JH, Huang YK, Gu SY, Ho HN, Ling TY. Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells . Molecular Human Reproduction .2014 ;(20):526-537

19. 2014 Lin MH,Cheng CH,Chen KC,Lee WT,Wang YF,Xiao CQ, Lin CW. Induction of ROS-independent JNK-activation-mediated Apoptosis by a Novel Coumarin-derivative, DMAC, in Human Colon Cancer Cells . Chemico-Biological Interactions .2014 ;(218):42-49

20. 2013 Lee LW,Wang GJ,Lin MH,Ju YM,Lin YW,Chen FY, Lee TH. Isolation and Characterization of Sesquiterpenes from Arecophila saccharicola YMJ96022401 with NO production inhibitory activity . Phytochemistry .2013 ;(85):129-136

21. 2012 Hsu FL,Huang WJ,Wu TH,Lee MH,Chen LC,Lu HJ, Hou WC, and Lin MH. Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from Pods of Caesalpinia pulcherrima . Int. J. Mol. Sci. .2012 ;(13):6073-6088

22. 2012 Lin PY,Yeh KS,Su CL,Sheu SY,Chen T,Ou KL, Lin MH, Lee LW. Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives . Molecules .2012 ;(17):10846-10863

23. 2012 Huang WJ,Wang YC,Chao SW,Yang CY,Chen LC,Lin MH, Hou WC, Chen, MY, Lee TL, Yang P, Chang CI. Synthesis and Biological Evaluation of ortho-ArylN-Hydroxycinnamides as Potent Histone Deacetylase(HDAC) 8 Isoform-Selective Inhibitors . ChemMedChem .2012 ;(7):1815-1824

24. 2012 Chen HL,Lee JF,Tseng SC,Lin MH,Liau WB. Photosensitized growth of TiO2 nanoparticles improved the charge transfer dynamics of a bichromophoric dye . Journal of Luminescence .2012 ;(132):2182-2187

25. 2012 Lee JF,Chen HL,Lee GS,Tseng SC,Lin MH,Liau WB. Photosensized Controlling Benzyl Methacrylate-based Matrix Enhanced Eu3+ Narrow-band Emission for Fluorescence Applications . Int.J. Mol. Sci. .2012 ;(13):3718-3737

26. 2011 Lia MJ,Chang JY,Lee HY,Kuo CC,Lin MH,Hsieh HP, Chang CY, Wu JS, Wu SY, Shey KS, Liou JP. Synthesis and Biological Evaluation of 1-(4’-Indolyl and 6’-Quinolinyl)indoles as a New Class of Potent Anticancer Agents. . Eur. J. Med. Chem. .2011 ;(46):3623-3629

27. 2011 Chin YP,Huang WJ,Hsu FL,Lin YL,Lin MH. Synthesis and Evaluation of Antibacterial Activities of 5, 7-Dihydroxycoumarin Derivatives . Arch Pharm .2011 ;(344):386-393

28. 2011 Lin MH,Chen HY,Liao TH,Huang TC,Lee JA. Determination of time-dependent accumulation of D-lactate in the streptozotocin-induced diabetic rat kidney by column-switching HPLC with fluorescence detection . Journal of Chromatography B .2011 ;(879):3214-3219

29. 2011 Lin MH,Chou YS,Tsai YJ,Chou DS. Antioxidant properties of 5,7-Dihydroxycoumarin derivatives in in vitro Cell-free and Cell-containing Systems . Journal of Experimental and Clinical Medicine .2011 ;(13):126-131

30. 2011 Lin MH,Liu HK,Huang WJ,Huang CC,Wu TH,Hsu FL. Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from Corni fructus to tackle insulin-dependent diabetes mellitus . J. Agr. Food Chem .2011 ;(59):7743-7751

31. 2011 Liao JH,Wu TH,Hsu FL,Huang YS,Chiang PH,Huang ZY, Huang CH, Wu SH*, Lin MH*. Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent . Int. J. Mol. Sci. .2011 ;(10):7059-7076

32. 2010 Huang WJ,Niu HS,Lin MH,Cheng JT,Hsu FL. Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats . J. Nat. Prod. .2010 ;(73):1170-1172

33. 2009 Liao JH,Chen CS,MalerTJ,Liu CY,Lin MH,Wu TH, Wu SH. Astaxanthin Interacts with Selenite and Attenuates Selenite-Induced Cataractogenesis . Chemical Research in Toxicology .2009 ;(22):518-525

34. 2006 Lin CM,Huang ST,Lee FW,Kuo HS,Lin MH. 6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents . Bioorganic & Medicinal Chemistry .2006 ;(14):4402-4409

35. 2005 Lin CH,Liu MC,Lin MS,Lin PL,Chen YH,Chen CT, Chen IM, Tsai MC. Effects of a New Isoquinolinone Derivative on Induction of Action Potential Burst in Central Snail Neuron . Pharmacology .2005 ;(75):98-110

36. 2005 Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC, Chen TY, Chen CT. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages . Planta Med. .2005 ;(71):748-753

37. 2005 Huang YH,Kuo SP,Lin MH,Shih CM,Chu ST,Wei CC, Wu TJ, Chen YH. Signals of Seminal Vesicle Autoantigen Suppresses Bovine Serum Albumin-induced Capacitation in Mouse Sperm . Biochemical and Biophysical Research Communications .2005 ;(338):1564-1571

38. 2004 Lin MS,Hsin LW,Cheng CY. Synthesis of 3-[4-Acyl-2-(1-methoxy-1-methylethyl)morpholin-3-yl]-benzonitriles asd Novel Potassium Channel Openers . Journal of the Chinese Chemical Society .2004 ;(51):157-165

39. 2003 Lin MS. A New Isoquinolinone Derivative with Noble Vasorelaxation Activity . Pharmacology .2003 ;(67):202-210

40. 2002 Lin MS. Synthesis of 1,4-Dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)-2H-isoquinolin-3-one and Related Compounds as Acetylcholine Release Enhancers . The Chinese Pharmaceutical Journal .2002 ;(54):271-281

41. 2001 Sung-Sen Yang, Pauling Chu, Mei-Shan Lin, An Chen, and Yuh-Feng Lin. Two Clinical Variants of Chinese-Herb Nephropathy: Case Reports and Review of the Literature . J. Med. Sci .2001 ;(21):217-22

42. 1996 林美香、蕭超隆、郭憲壽. 雜環昆類之生理活性6-烷硫-7-氨基及6-氨基-7-烷硫-5,8-奎林酮之合成與抗生活性. . JTMC .1996 ;(25):12-21


1. 2005 wei CC,Kuo SP,Chio YY,Wu IZ,Chang CC,Lin MS. Seminal Vesicle Autoantigen Suppresses the Level of Intracellular Calcium, pH Value, cAMP, and Protein Tyrosine Phosphorylation Induced by Bovine Serum Albumin. . The 20th Joint Annual Conference of Biomedical sciences, Taipei, Taiwan.(O91) .2005

研究計畫

計畫名稱
112 113年度「藥品品質規範國際協和化」委託辦理計畫分項計畫二:原料藥及賦形劑品質規範國際協和化
補助單位
衛生福利部食品藥物管理署

計畫名稱
111 「112年度「藥品品質規範國際協和化」委託辦理計畫」之「分項計畫二:原料藥及賦形劑品質規範國際協和化」
補助單位
衛生福利部食品藥物管理署

計畫名稱
110 111年度「導入國際化藥品品質規範與技術方法」委託辦理計畫分項二:國際化藥品品質規範之建構
補助單位
衛生福利部食品藥物管理署

計畫名稱
109 新興影響精神活性物質流行趨勢分析、標準品合成及圖譜建立
補助單位
衛生福利部食品藥物管理署

計畫名稱
108 109年度「藥品品質分析檢驗方法現代化」委託辦理計畫
補助單位
衛生福利部食品藥物管理署

計畫名稱
107 108年度「藥品品質分析檢驗方法現代化」委託辦理計畫
補助單位
衛生福利部食品藥物管理署

計畫名稱
106 107年度「加速暨完備藥品品質檢驗方法國際化」委託辦理計畫分項一:加速藥品品質檢驗方法之國際化
補助單位
衛生福利部食品藥物管理署

計畫名稱
105 設計及合成香豆素衍生物作為單羧酸轉運蛋白 MCTs抑制劑之活性研究
補助單位
科技部

計畫名稱
102 異甜菊醇衍生物之合成及降血糖研究
補助單位
行政院國家科學委員會

計畫名稱
102 異甜菊醇衍生物之合成及降血糖研究
補助單位
科技部

計畫名稱
100 藥學系學生實習培訓計畫
補助單位
行政院衛生署中醫藥委員會

計畫名稱
96 合成具有新型螢光性質之抗發炎藥物及其結合發炎細胞應用於光譜分析之研究
補助單位
行政院國家科學委員會

計畫名稱
96 Isosteviol衍生物作為先導藥物之探索
補助單位
行政院國家科學委員會

計畫名稱
95 合成具有高效率電子傳輸功能的發光材料及其掺雜lanthanide金屬在DNA結合的研究
補助單位
行政院國家科學委員會

計畫名稱
94 四、六位取代coumarin衍生物之合成及其抑制乙醯膽鹼酯酶和乙醯膽鹼酯酶誘導beta-amyloid凝集活性之研究
補助單位
行政院國家科學委員會

計畫名稱
93 天然物Ochrocarpin B之全合成
補助單位
行政院國家科學委員會

計畫名稱
93 四位取代喃咕嗎衍生物之合成及其抗發炎活性之藥理研究
補助單位
臺北醫學大學專題