| 1. |
2023
Teng, R.D.,Yang, C.H.,Chung C.L., Sheu, J.R.,Hsieh, C.Y..
Attenuation of indoxyl sulfate-induced cell damage by cinchonidine-a Cinchona alkaloid through the downregulation of p53 signaling pathway by promoting MDM2 cytoplasmic-nuclear shuttling in endothelial cells.
. Life Sciences
.2023
|
|
| 2. |
2023
Hsia, C.W.,Huang, W.C.,Jayakumar, T.,Hsia, C.H.,Hou, S.M.,Chang, C.C., Yen, T.L., Sheu, J.R..
Garcinol acts as a novel integrin αIIbβ3 inhibitor in human platelets.
. Life Sciences
.2023
|
|
| 3. |
2023
Huang, W.C.,Jayakumar, T.,Sheu, J.R. ,Hsia, C.W.,Hsia, C.H.,Yen, T.L., and Chang, C.C..
Mechanisms of glabridin inhibition of Integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets.
. Chin. Med.-UK
.2023
|
|
| 4. |
2023
Lu, K.J., Sheu, J.R.,Teng, R.D.,Jayakumar, T.,Chung, C.L.,Hsieh, C.Y. .
Ability of local clearance of senescent cells in ipsilateral hemisphere to mitigate acute ischemic brain injury in mice.
. Int. J. Biol. Sci.
.2023
|
|
| 5. |
2023
Lu, K.J.,Yang, C.H.,Sheu, J.R.,Chung, C.L.,Jayakumar, T.,Chen, C.M., Hsieh, C.Y. .
Overexpressing glyoxalase 1 attenuates acute hyperglycemia−exacerbated neurological deficits of ischemic stroke in mice.
. Transl. Res.
.2023
|
|
| 6. |
2023
Hsieh, C.Y.,Jayakumar, T.,Lin, K.C.,Yen, T.L.,Hsia, C.W, Huang, W.C., Sheu, J.R., and Hsia, C.H. .
Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules.
. Eur. J. Inflamm.
.2023
|
|
| 7. |
2023
Chang, Y., Hsia, C.W.,Huang, W.C.,Jayakumar, T.,Hsia, C.H,Yen, T.L., Sheu, J.R., Hou, S.M..
Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans
. Heliyon
.2023
|
|
| 8. |
2023
Jayakumar, T.,Sheu, J.R. ,Yuan, K.C.,Yen, T.L,Hsia, C.W,Huang, W.C., Tseng, L.N., Chen, C.H., Hsia, C.H..
Anti-inflammatory mechanism of morin hydrate by suppressing the NF-κB/MAPKs mediated cell migration and modulating Src/FAK and β-catenin
. Natural Product Commun
.2023
|
|
| 9. |
2022
Decreased human platelet activation and mouse pulmonary thrombosis by rutaecarpine and comparison of the relative effectiveness with BAY11-7082: crucial signals of p38-NF-κB.
. Molecules
.2022
;(27):1-14
|
|
| 10. |
2022
Targeting MAPK/NF-κB pathways in anti-inflammatory potential of rutaecarpine: impact on Src/FAK-mediated macrophage migration.
. Int. J. Mol. Sci.
.2022
;(23):1-15
|
|
| 11. |
2022
Anti-inflammatory mechanism of an alkaloid rutaecarpine in LTA-stimulated RAW 264.7 cells: pivotal role on NF-κB and ERK/p38 signaling molecules.
. Int. J. Mol. Sci.
.2022
|
|
| 12. |
2022
Influence of garlic (Allium sativum) clove‑based selenium nanoparticles on status of nutritional, biochemical, enzymological, and gene expressions in the freshwater prawn Macrobrachiumrosenbergii (De Man, 1879).
. Biol. Trace Elem. Res.
.2022
|
|
| 13. |
2022
Yohimbine, an alpha 2-adrenoceptor antagonist, suppresses PDGF-BB-stimulated vascular smooth muscle cell proliferation by downregulating the PLC1 signaling pathway.
. Int. J. Mol. Sci.
.2022
|
|
| 14. |
2022
Activation of Nrf2 by esculetin mitigates inflammatory responses through suppression of NF-κB signaling cascade in RAW 264.7 Cells.
. Molecules
.2022
|
|
| 15. |
2022
Nature or synthetic compounds for treating arterial thrombosis and ischemic stroke.
. Appl. Sci.
.2022
|
|
| 16. |
2022
Glabridin, a bioactive flavonoid from licorice, effectively inhibits platelet activation in humans and mice.
. Int. J. Mol. Sci.
.2022
|
|
| 17. |
2021
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK/mTOR to sphingolipid metabolism.
. Autophagy
.2021
|
|
| 18. |
2021
Pterostilbene, a dimethylether analogue of resveratrol, possesses high potency in the prevention of platelet activation in humans and reduction of vascular thrombosis in mice.
. J. Agri. Food Chem.
.2021
|
|
| 19. |
2021
The antithrombotic agent pterostilbene interferes with integrin αiibβ3-mediated inside-out and outside-in signals in human platelets.
. Int. J. Mol. Sci.
.2021
|
|
| 20. |
2021
Columbianadin dampens in vitro inflammatory actions and inhibits liver injury via inhibition of NF-κB/MAPKs: impacts on OH redicals and HO-1 expression.
. Antioxidants
.2021
|
|
| 21. |
2021
Involvement of antioxidant defenses and NF-κB/ERK signaling in anti-inflammatory effects of natural stilbenoid pterostilbene.
. Appl. Sci.
.2021
|
|
| 22. |
2021
First record of a seed shrimp (Ostracoda: Podocopida) Cypretta campechensis (Cyprididae) in a perennial lake (Coimbatore, India): Its molecular identification.
. Int. J. Fauna Biol. Study
.2021
|
|
| 23. |
2021
Hsia, C.W.,Huang, W.C.,Yang, C.H.,Hsia, C.H.,Jayakumar, T.,Bhavan, P.S., Sheu, J.R., Chiou, K.R. .
Comparison of the potency of pterostilbene with NF-B inhibitors in platelet activation: mutual activation by Akt-NF-B signaling in human platelets.
. Appl. Sci.
.2021
|
|
| 24. |
2021
Lien, L.M.,Lu, W.J.,Lin, K.H.,Kang, L.H.,Chen, T.Y.,Lin, B.J., Lu, Y.C., Huang, C.Y., Shih, C.M., Chen, H., Tsai, Y.C., Chen, R.J., and Sheu, J.R..
Influence of vincristine, clinically used in cancer therapy and immune thrombocytopenia, on the function of human platelets.
. Molecules
.2021
|
|
| 25. |
2021
Huang, C.J.,Huang, W.C.,Lin, W.T.,Shu, L.H.,Sheu, J.R. ,Tran, O.T., Hsia, C.W., Jayakumar, T., Bhavan, P.S., Hsieh, C.Y., Chang, C.C..
Rutaecarpine, an alkaloid from Evodia rutaecarpa, can prevent platelet activation in humans and reduce microvascular thrombosis in mice: crucial role of the PI3K/Akt/GSK3β signal axis through a cyclic nucleotides/VASP-independent mechanism.
. Int. J. Mol. Sci.
.2021
|
|
| 26. |
2021
Jayakumar, T.,Sheu, J.R. ,Hsia, C.W.,Bhavan, P.S.,Chang, C.C. .
Anti-inflammatory mechanisms of novel synthetic ruthenium compounds.
. Appl. Sci.
.2021
|
|
| 27. |
2021
Hsia, C.H.,Jayakumar, T.,Lu, W.J.,Sheu, J.R. ,Hsia, C.W.,Bhavan, P.S., Manubolu, M., Huang, W.C., Chang, Y..
Auraptene, a monoterpene coumarin, inhibits LTA-induced inflammatory mediators via modulating NF-κB/MAPKs signaling pathways.
. Evid-Based Comple. Alter. Med.
.2021
|
|
| 28. |
2020
Boopathy, A.B.,Jayakumar, T.,Rajaram, M.G.,Mohan, N.,Senthil, C.,Nagaraj S., Rengasamy, R., Manubolu, M., Sheu, J.R., Chang, C.C.
Biomass and lipid production potential of an indian marine algal isolate Tetraselmis striata BBRR1.
. Energies
.2020
;(13)
|
|
| 29. |
2020
Jayakumar, T.,Huang, H.C.,,Hsia, C.W.,Fong, T.H.,Khamrang, T.,Manubolu, M., Sheu, J.R., Hsia, C.H. .
Ruthenium derivatives attenuate LPS-induced inflammatory responses and liver injury via suppressing NF-B signaling and free radical production.
. Bioorganic Chem.
.2020
;(96)
|
|
| 30. |
2020
Hou, S.M.,,Hsia, C.W.,Tsai, C.L.,,Hsia, C.H.,Jayakumar, T.,,Velusamy, M., Sheu, J.R. .
Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals.
. J. Biomed. Sci.
.2020
|
|
| 31. |
2020
Hsia, C.H.,Jayakumar, T.,Sheu, J.R. ,Hsia, C.W.,Huang, W.C.,Velusamy, M., Lien, L.M. .
Synthetic ruthenium complex TQ-6 potently recovers cerebral ischemic stroke: attenuation of microglia and platelet activation.
. J. Clin. Med.
.2020
;(9)
|
|
| 32. |
2020
Lee, T.Y.,Jayakumar, T.,Thanasekaran, P.,Lin, K.C.,Chen, H.M.,Veerakumar, P., Sheu, J.R. .
Carbon dot nanoparticles exert inhibitory effects on human platelets and reduce mortality in mice with acute pulmonary thromboembolism.
. Nanomaterials
.2020
|
|
| 33. |
2020
Hsia, C.W.,Wu, M.P.,Shen, M.Y.,Hsia, C.H.,Chung, C.L., Sheu, J.R. .
Regulation of human platelet activation and prevention of arterial thrombosis in mice by auraptene through inhibition of NF-κB pathway.
. Int. J. Mol. Sci.
.2020
;(21):1-14
|
|
| 34. |
2020
Jayakumar, T.,Bhavan, P.S.,,Sheu, J.R..
Molecular targets of natural products for chondroprotection in destructive joint diseases.
. Int. J. Mol. Sci.
.2020
|
|
| 35. |
2020
Hsia, C.W.,Yang, C.H., Sheu, J.R. .
Reduction of NF-B signals in platelets and prolongation of platelet plug formation against high shear flow in whole blood on human subjects by Columbianadin.
. Appl. Sci.
.2020
;(10):1-15
|
|
| 36. |
2019
Lu, W.J. ,Lin, K.H., Tseng, M.F.,Yuan, K.C.,Huang, H.C., ,Sheu, J.R..
New therapeutic strategy of hinokitiol in hemorrhagic shock-induced liver injury.
. J. Cell. Mol. Med.
.2019
;(23):1723-1734
|
|
| 37. |
2019
Chih-Wei Hsia,Cheng-Lin Tsai,Joen-Rong Sheu,Wan-Jung Lu,Chih-Hsuan Hsia ,Marappan Velusamy, Thanasekaran Jayakumar, Jiun-Yi Li.
Suppression of human platelet activation via integrin αIIbβ3 outside-in independent signal and reduction of the mortality in pulmonary thrombosis by auraptene.
. Int. J. Mol. Sci.
.2019
;(20)
|
|
| 38. |
2019
Hsieh, C.Y.,Sheu, J.R.,Yang, C.H.,Chen, W.L.,Tsai, J.H.,Chung, C.L..
Thrombin Upregulates PAI-1 andMesothelial–Mesenchymal Transition Through PAR-1 and Contributes to Tuberculous Pleural Fibrosis.
. Int. J. Mol. Sci.
.2019
;(20)
|
|
| 39. |
2019
Manubolu, M.,Pathakoti, K.,Jayakumar, T.,Sheu, J.R.,Fraker, M.,Tchounwou, P., Poondamalli, P.R., Goodla, L..
Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats.
. Int. J. Env. Res. Pub. He.
.2019
;(16)
|
|
| 40. |
2019
Hsia, C.W.,Lin, K.C.,Lee, T.Y.,Hsia, C.H.,Chou, D.S.,Jayakumar, T., Velusamy, M., Chang, C.C., Sheu, J.R..
Esculetin, a coumarin derivative, prevents thrombosis: inhibitory signaling on PLCγ2–PKC–AKT activation in human platelets.
. Int. J. Mol. Sci.
.2019
;(20)
|
|
| 41. |
2019
Sheu, J.R.,Hsieh, C.Y.,Jayakumar, T.,Tseng, M.F.,Lee, H.N.,Huang, S.W., Manubolu, M., Yang, C.H..
A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis.
. Front. Neurosci.
.2019
;(13)
|
|
| 42. |
2019
Sheu, J.R..
Molecular Pharmacology and Pathology of Strokes
. Int. J. Mol. Sci.
.2019
;(19)
|
|
| 43. |
2019
Jayakumar, T.,Huang, H.C.,Hsia, C.W.,Fong, T.H., Khamrang, T.,Manubolu, M., Sheu, J.R., Hsia, C.H..
Ruthenium derivatives attenuate LPS-induced inflammatory responses and liver injury via suppressing NF-kB signaling and free radical production.
. Bioorganic Chem.
.2019
|
|
| 44. |
2019
Hsia, C.W.,Shyu, K.G.,Jayakumar, T.,Hsia, C.H.,Velusamy, M.,Yang, C.H., Sheu J.R. .
Natural coumarin derivative esculetin regulates platelet activation via modulating NF-κB signaling in cyclic nucleotide-independent manner.
. Nat. Prod. Commun.
.2019
|
|
| 45. |
2019
Sheu JR,Hsieh CY,Jayakumar T,Lin GY,Lee HN,Huang SW, Yang CH .
HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.
. J. Biomed. Sci.
.2019
;(26):1-17
|
|
| 46. |
2019
Protective effects of Ammannia baccifera against CCl4-induced oxidative stress in rats.
. Int. J. Env. Res. Pub. He.
.2019
|
|
| 47. |
2019
Hsia, C.W,Lin, K.C.,Lee, T.Y.,Chou, D.S.,Jayakumar, T.,elusamy, M., Chang, C.C., Sheu, J.R..
Esculetin, a coumarin derivative, prevents thrombosis: inhibitory signaling on PLCγ2–PKC–AKT activation in human platelets.
. Int. J. Mol. Sci.
.2019
;(20)
|
|
| 48. |
2018
Hsia, C.H.,Jayakumar, T.,Sheu, J.R. ,Tsao, S.Y.,Velusamy, M.,Hsia, C.W., Chou, D.S., Chang, C.C., Chung, C.L., Khamrang, T., Lin, K.C..
Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets.
. Molecules
.2018
|
|
| 49. |
2018
Shyu, K.G.,Velusamy, M.,Hsia, C.W.,Yang, C.H.,Hsia, C.H.,Chou, D.S., Jayakumar, T., Sheu, J.R., LI, J.Y..
Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation.
. Int. J. Mol. Med.
.2018
;(41):2589-2600
|
|
| 50. |
2018
Shyu, R.S.,Khamrang, T.,Sheu, J.R.,Hsia, C.W.,Velusamy, M.,Hsia, C.H., Chou, D.S., Chang, C.C. .
Ir-6: a novel iridium (III) organometallic derivative for inhibition of human platelet activation.
. Bioinorg. Chem. Appl.
.2018
|
|
| 51. |
2018
Jayakumar, T., Liu, C.H.,Wu, G.Y.,Lee, T.Y.,Manjunath, M.,Hsieh, C.Y., Yang, C.H., Sheu, J.R..
Hinokitiol inhibits migration of A549 lung cancer cells via suppressing MMPs and inducing antioxidant enzymes and apoptosis.
. Int. J. Mol. Sci.
.2018
|
|
| 52. |
2018
Rajarajam, M.G.,Nagaraj, S.,Manjunath, M.,Annakili, B.B.,Kurinjimalar, C.,Rengasamy, R., Jayakumar, T., Sheu, J.R., Li, J.Y..
Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond.
. Energies
.2018
|
|
| 53. |
2018
Jayakumar, T.,Hsu, C.Y.,Khamrang, T.,Hsia, C.H.,Hsia, C.W.,Manjunath, M., Sheu, J.R..
Possible molecular targets of novel ruthenium complexes in antiplatelet therapy.
. Int. J. Mol. Sci.
.2018
|
|
| 54. |
2018
Hsia, C.W.,Wu, M.P., Velusamy, M.,Hsia, C.H.,Chou, D.S.,Tsai, C.L., Hsu, C.Y., Jayakumar, T., Chung, C.L., Sheu, J.R. .
Novel therapeutic agent against platelet activation in vitro and arterial thrombosis in vivo by morin hydrate.
. Int. J. Mol. Sci.
.2018
|
|
| 55. |
2018
Wu, M.P.,Chang, N.C.,Chung, C.L.,Chiu, W.C.,Hsu, C.C.,Chen, H.M., Sheu, J.R., Jayakumar, T., Chou, D.S., Fong, T.H..
Analysis of titin in red and white muscles: crucial role on muscle contractions using a fish model.
. BioMed. Res. Intl.
.2018
|
|
| 56. |
2018
Lu, W.J.,Chung, C.L. ,Chen, R.J. ,Huang, L.T,Lien, L.M.,Chang, C.C., Lin, K.H., Sheu, J.R..
A novel antithrombotic strategy by targeting phospholipase D in human platelets.
. J. Clin. Med.
.2018
|
|
| 57. |
2018
Hsia, C.H. ,Velusamy, M. ,Jayakumar T. ,Chen, Y.J.,Hsia, C.W. ,Tsai, J.H., Teng, R.D., Sheu, J.R..
Mechanisms of TQ-6, a novel ruthenium-derivative compound, against lipopolysaccharide-induced in vitro macrophage activation and liver injury in experimental mice: the crucial role of p38 MAPK and NF-κB signaling.
. Cells
.2018
|
|
| 58. |
2018
Yang, C.H.,Hsia, C.W. ,Jayakumar, T.,Sheu, J.R.,Hsia, C.H. ,Khamrang, T, Chen, Y.J., Manubolu, M., Chang, Y..
Structure-activity relationship study of newly synthesized iridium-III complexes as potential series for treating thrombotic diseases.
. Int. J. Mol. Sci.
.2018
|
|
| 59. |
2018
Sheu, J.R.,Chen, Z.C.,Hsu, M.J.,Wang, S.H.,Jung, K.W.,Wu, W.F., Pan, S.H., Teng, R.D., Yang, C.H., Hsieh, C.Y..
CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated PP2A activation.
. J. Cell. Mol. Med.
.2018
|
|
| 60. |
2018
Hsia, C.H.,Lu, W.J.,Lin, K.H.,Chou, D.S.,Geraldine, P.,Jayakuma, T., Chang, N.C., Sheu, J.R..
NCTD, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin IIb3 binding in human platelets.
. J. Cell. Mol. Med.
.2018
;(22):2142-2152
|
|
| 61. |
2017
Chang Y.,Li, J.Y.,Jayakumar T.,Hung S.H.,Lee, W.C.,Manjunath, M., Sheu, J.R., Hsu, M.J..
Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition
. Int. J. Mol. Sci.
.2017
;(18)
|
|
| 62. |
2017
Hsu, L.W.,Shiao, W.C.,Chang, N.C.,Yu, M.C.,Yen, T.L,Aloysius, P.T., Jayakumar, T., Sheu, J.R..
Tao-Ren-Cheng-Qi Tang protects rats against embolic stroke through TNF-α/p-JNK expression, OH radical formation and cell apoptosis.
. Chin. Med.-UK
.2017
;(12):1-7
|
|
| 63. |
2017
Hsia, C.W.,Velusamy, M.,Tsao, J.T.,Hsia, C.H.,Chou, D.S.,Jayakumar, T., Lee, L.W., Li, J.Y., and Sheu, J.R. .
New therapeutic agent against arterial thrombosis: an iridium (III)-derived organometallic compound.
. Int. J. Mol. Sci.
.2017
|
|
| 64. |
2017
Sheu, J.R.,Chen, Z.C.,Jayakumar, T.,Chou, D.S.,Yen, T.L.,Li, H.N., Pan, S.H., Hsia, C.H., Yang, C.H., Hsieh, C.Y..
A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice.
. Sci. Rep-UK
.2017
|
|
| 65. |
2017
Lee, T.Y.,Chang, C.C.,Lu, W.J.,Yen, T.L.,Lin, K.H.,Geraldine, P., Li, J.Y., Sheu, J.R..
Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies.
. Sci. Rep.
.2017
;(7):1-13
|
|
| 66. |
2017
Wang, C.L.,Yang, P.S.,Tsao, J.T.,Jayakumar T.,Wang, M.J.,Sheu, J.R., Chou, D.S..
Mechanisms of free radical generation in platelets and primary hepatocytes: a novel electron spin resonance study.
. Mol. Med. Rep.
.2017
;(17):2061-2069
|
|
| 67. |
2017
,Jayakumar, T., Sheu, J.R..
Antiplatelet activity of a newly synthesized novel ruthenium (III) complex: potential role for Akt/JNK signaling.
. Int. J. Mol. Sci.
.2017
;(18):1-15
|
|
| 68. |
2017
Anbukkarasia, M.,Thomasb, P.A.,Sheu, J.R.,Geraldinea, P..
In vitro antioxidant and anticataractogenic potential of silver nanoparticles biosynthesized using an ethanolic extract of Tabernaemontana divaricata leaves.
. Biomed. Pharmacother.
.2017
;(91):467-475
|
|
| 69. |
2017
Yang, C.H.,Yen, T.L.,Hsu, C.Y.,Thomas, P.A.,Sheu, J.R..
Multi-targeting andrographolide, a novel NF-κB inhibitor, as potential therapeutic agent for stroke.
. Int. J. Mol. Sci.
.2017
;(18):1-13
|
|
| 70. |
2017
Hsia, C.H.,Velusamy, M.,Sheu, J.R.,Khamrang, T.,Jayakumar, T.,Lu, W.J., Lin, K.H., Chang, C.C. .
A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies.
. Sci. Rep-UK
.2017
;(7)
|
|
| 71. |
2017
Yao, W.C.,Yuan, L.T.,Yang, W.B.,Hsia, C.H.,Huang, L.T.,Lee, T.Y., Sheu, J.R., Lu, W.J., Jayakumar, T., Chen, R.J..
Development of benzimidazole derivatives as novel anti-platelet drugs.
. Curr. Pharm. Biotechnol.
.2017
;(18)
|
|
| 72. |
2016
Yen,TL,Chen RJ,Jayakumar T,Lu WJ,Hsieh CY,Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, and Sheu JR.
Andrographolide stimulates p38 MAPK-Nrf2-HO-1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.
. Transl. Res.
.2016
;(170):57-72
|
|
| 73. |
2016
Lin, K.H.,Lin, K.C.,Lu, W.J.,Thomas, P.A.,Jayakumar, T.,Sheu, J.R..
Astaxanthin, a carotenoid stimulates immune responses by enhancing IFN-γ and IL-2 secretion in primary cultured lymphocytes in vitro and ex vivo.
. Int. J. Mol. Sci.
.2016
|
|
| 74. |
2016
Shen, M.Y.,Chen, F.Y.,Hsu, J.F.,Fu, R.H.,Chang, C.M.,Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura.
Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation.
. Blood
.2016
;(127):1336-1345
|
|
| 75. |
2016
Yen, T.L.,Wu, M.P.,,Chung, C.L.,Yang, W.B.,Jayakumar, T.,Geraldine, P, Chou, C.M., Chang, C.Y., Lu, W.J., and Sheu, J.R..
Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism.
. J. Biomed. Sci.
.2016
|
|
| 76. |
2016
Jayakumar, T.,Yang, C.H.,Geraldine, P.,Yen, T.L.,Sheu, J.R..
The pharmacodynamics of antiplatelet compounds in thrombosis treatment
. Expert Opin. Drug Met. Toxicol.
.2016
|
|
| 77. |
2016
Chang, Y.,Hsu, W.S.,Yang, W.B.,Jayakumar, T.,Lee, T.Y.,Sheu, J.R., Lu, W.J., Li, J.Y..
Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation.
. Int. J. Mol. Med. (in press)
.2016
|
|
| 78. |
2016
Jayakumar, T.,Lin, K.C.,Lu, W.J.,Lin, C.Y.,Pitchairaj, G.,Li, J.Y., Sheu, J.R..
Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide mechanisms.
. Int. J. Mol. Med. (in press)
.2016
|
|
| 79. |
2016
Tzu-Yin Lee,Chao-Chien Chang,Wan-Jung Lu,Ting-Lin Yen,Kuan-Hung Lin,Pitchairaj Geraldine5, Jiun-Yi Li6*, and Joen-Rong Sheu1.
Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies
. Sci. Rep-UK (in press)
.2016
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|
| 80. |
2016
Lu, W.J.,Lin, K.C.,Liu, C.P.,Lin, C.Y.,Wu, H.C.,Chou, D.S., Geraldine, P., Huang, S.Y., Hsieh, C.Y., Sheu, J.R..
Prevention of arterial thrombosis by nobiletin: in vitro and in vivo studies.
. J. Nutri. Biochem.
.2016
;(28):1-8
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| 81. |
2016
Jayakumar, T.,Yang, C.H.,Geraldine, P.,Yen, T.L.,Sheu, J.R..
The pharmacodynamics of antiplatelet compounds in thrombosis treatment .
. Expert Opin. Drug Met. Toxicol.
.2016
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|
| 82. |
2015
Kao, M.C.,Chung, C.Y.,Chang, Y.Y.,Lin, C.K.,Sheu, J.R.,Huang, C.J..
Salutary effects of cepharanthine against skeletal muscle and kidney injuries following limb ischemia/reperfusion.
. Evid. Based Complement Alternat. Med. DOI: 10.1155/2015/504061.
.2015
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| 83. |
2015
Lien, L.M.,,Wang, M.J.,Chen, R.J.,Chiu, H.C.,Wu, J.L.,Shen, M.Y., Sheu, J.R., Lin, K.H., Lu, W.J..
Nobiletin, a polymethoxylated flavone, inhibits glioma cell growth and migration via arresting cell cycle and suppressing MAPK and Akt pathways.
. Phytother. Res. (in press)
.2015
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| 84. |
2015
Chen, W.L.,Sheu, J.R.,Chen, R.J.,Hsiao, S.H.,Hsiao, C.J.,Chou, Y.C., Chung, C.L., Hsiao, G..
Mycobacterium tuberculosis upregulates TNF-α expression via TLR2/ERK signaling and induces MMP-1 and MMP-9 production in human pleural mesothelial cells.
. PLoS One 10(9): e0137979. doi: 10.1371/journal.pone.0137979.
.2015
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| 85. |
2015
Sheu, J.R.,Thomas, P.A.,Cheng, J.T..
Novel Drugs Development for Cardio-/Cerebrovascular Diseases.
. BioMed Res. Intl. DOI: 10.1155/2014/467936.
.2015
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| 86. |
2015
Sheu, J.R.,Geraldine, P.,Yen, M.H..
Bioactives and Traditional Herbal Medicine for the Treatment of Cardiovascular/Cerebrovascular Diseases.2014/495323.
. Evid Based Complement Alternat Med. DOI: 10.1155/2014/495323.
.2015
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| 87. |
2015
Sheu, J.R.,Geraldine, P.,Yen, M.H..
Bioactives and Traditional Herbal Medicine for the Treatment of Cardiovascular/Cerebrovascular Diseases.
. Evid Based Complement Alternat Med. DOI: 10.1155/2015/320545.
.2015
|
|
| 88. |
2015
Huang, C.H.,Lu, S.H.,Chang, C.C,Thomas, P.A.,Jayakumar, T.,Sheu, J.R..
Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation.
. Eur. J. Pharmacol.
.2015
;(746):148-157
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|
| 89. |
2015
Chang YF,Hsu YF,Chiu PT,Huang WJ,Huang SW,Ou G, Sheu JR, Hsu MJ.
WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain-containing protein tyrosine phosphatase 1
. Oncotarget
.2015
;(6):85-100
|
|
| 90. |
2015
Lee, J.J.,Chang, C.F.,Sheu, J.R.,Jayakumar, T..
Pharmacology and clinical effect of platonin, a cyanine photosensitizing dye: potential molecular targets
. Curr. Pharm. Biotechnol.
.2015
;(15):700-711
|
|
| 91. |
2015
Chang, Y.,Hsu, W.H.,Lu, W.J.,Jayakumar, T.,Liao, J.C.,Lin, M.J.Wang, S.H., Geraldine, P., Lin, K.H., Sheu. J.R..
Inhibitory mechanisms of CME-1, a novel polysaccharide from the mycelia of Cordyceps sinensis, in platelet activation.
. Curr. Pharm. Biotechnol.
.2015
;(16):451-461
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|
| 92. |
2015
Chen, W.Y.,Chen, F.Y.,Lee, A.S.,Ting, K.H.,Chang, C.M.,Hsu, J.F., Lee, W.S., Sheu, J.R., Chen, C.H., Shen, M.Y..
Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro.
. J. Nat. Prod. 78(2): 225-33.
.2015
;(78):225-233
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|
| 93. |
2015
Kao, M.C.,Yang, C.H.,Chou, W.C.,Sheu, J.R.,Huang, C.J..
Cepharanthine mitigates lung injury in lower limb ischemia-reperfusion.
. J. Surg. Res.
.2015
;(199):647-656
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|
| 94. |
2015
Muralidharan, A,Selvaraj, C.,Singh, S. K.,Sheu, J.R.,Thomas, P.A.,Geraldine, P..
Structure-based virtual screening and biological evaluation of a calpain inhibitor for prevention of selenite-induced cataractogenesis in an in vitro system.
. J. Chem. Inf. Model.
.2015
;(55):1686-1697
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| 95. |
2015
Lu,W.J.,Chang, C.C.,Lien, L.M.,Yen, T.L.,Chiu, H.C.,Huang, S.Y., Sheu, J.R., Lin, K.H..
Xanthohumol from Humulus lupulus L. induces glioma cell autophagy via inhibiting Akt/mTOR/S6K pathway.
. J. Funct. Foods
.2015
;(18):538-549
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| 96. |
2015
Kao, M.C.,Yang, C.H.,Sheu, J.R.,Huang, C.J..
Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats.
. Cytokine
.2015
;(76):442-448
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|
| 97. |
2015
Huang, C.H.,Jayakumar, T.,Chang, C.C.,Fong, T.H.,Lu, S.H.,Thomas, P.A., Choy, C.S., Sheu, J.R..
Hinokitiol exerts anticancer activity through downregulation of MMPs 9/2 and enhancement of catalase and SOD enzymes: In-vivo augmentation of lung histoarchitecture.
. Molecules
.2015
;(20):17720-17734
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| 98. |
2014
Chang YF,Hsu YF,Chiu PT,Huang WJ,Huang SW,Ou G, Sheu JR, Hsu MJ.
WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain-containing protein tyrosine phosphatase 1
. Oncotarget
.2014
;(6):85-100
|
|
| 99. |
2014
Lee, Y.M.,Chang, C.Y.,Yen, T.L.,Geraldine, P.,Lan, C.C.,Sheu, J.R. (corresponding author), Lee. J.J..
Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence.
. Sci. World J. DOI:10.1155/2014/686109
.2014
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| 100. |
2014
Chen, Y.Y.,Hsu, M.J.,Hsieh, C.Y.,Lee, L.W,Chen, Z.C,Sheu, J.R..
Andrographolide inhibits nuclear factor-B activation through JNK-Akt-p65 signaling cascade in tumor necrosis factor-alpha-stimulated vascular smooth muscle cells.
. Sci. World J. DOI:10.1155/2014/130381
.2014
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| 101. |
2014
Chen YY,Hsieh CY,Jayakumar T,Lin KH,Chou DS,Lu WJ, Hsu MJ, Sheu JR.
Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade.
. Sci. Rep. DOI:10.1038/srep05651.
.2014
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| 102. |
2014
Lien, L.M.,Chen, Z.C.,Chung, C.L.,Yen, T.L.,Chiu, H.C.,Chou, D.S., Sheu, J.R., Lu, W.J. and Lin, KH.
Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo.
. Eur. J. Pharmacol.
.2014
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| 103. |
2014
Yen, T.L.,Lu, W.J.,Lien, L.M.,Thomas, P.A.,Lee, T.Y.,Chiu, H.C., Sheu, J.R. (corresponding author), Lin, K.H..
Amarogentin isolated from Gentiana lutea inhibits platelet activation through the inhibition of PLCgamma2-PKC and MAPK pathways.
. BioMed. Res. Intl. 2014:728019. doi:10.1155/2014/728019.
.2014
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| 104. |
2014
Chuang, Y.F.,Yang, H.Y.,Ko, T.L.,Hsu, Y.F.,Sheu, J.R.,Ou, G., Hsu, M.J..
Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells.
. Biochem. Pharmacol.
.2014
;(88):372-383
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| 105. |
2014
Lin, K.H.,Lu, W.J.,Wang, S.H.,Fong, T.H.,Chou, D.S.,Chang, C.C., Chang, N.C., Chiang, Y.C., Sheu, J.R..
Characteristics of endogenous -aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor.
. J. Mol. Med.
.2014
;(92):603-614
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| 106. |
2014
Chen, W.L.,Sheu, J.R.,Hsiao, C.J.,Hsiao, S.H.,Chung, C.L.,Hsiao, G..
Histone deacetylase inhibitor impairs plasminogen activator inhibitor-1 expression via inhibiting TNF-𝛼-activated MAPK/AP-1 signaling cascade.
. BioMed. Res. Intl. 2014:231012. doi:10.1155/2014/231012.
.2014
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| 107. |
2014
Huang, Y.K.,Lee, W.F.,Wang, M.J.,Chang, Y.H.,Tchaou, W.S.,Chang, W.J., Lee, S.Y., Sheu, J.R..
Chair-side quantitative oral-microflora screening for assessing familial correlation of periodontal status and caries prevalence.
. PLoS ONE 30; 9: e87100.doi:10.1371/journal.pone.0087100.
.2014
;(9)
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| 108. |
2014
Shyu, K.G.,Chang, C.C.,Yeh, Y.C.,Sheu, J.R.,Chou, D.S..
Mechanisms of ascorbyl radical formation in human platelet-rich plasma.
. BioMed. Res. Intl. 2014:614506. doi:10.1155/2014/614506.
.2014
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| 109. |
2014
Hsieh, C.Y.,Hsiao, G.,Hsu, M.J.,Hsu, M.J.,Wang, Y.H.,Sheu, J.R. (corresponding author).
PMC, a potent hydrophilic -tocopherol derivative, inhibits NF-B activation via protein phosphatase 2A mediated IB-independent pathway in LPS/IFN- activated vascular smooth muscle cells.
. J. Cell. Mol. Med.
.2014
;(18):1278-1289
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| 110. |
2014
Lu WR,Lin KC,Huang SY,Thomas Philip Aloysi,Wu YU,Wu HC, Lin KH, Sheu JR.
Role of a Janus kinase 2-dependent signaling pathway in platelet activation
. Thromb. Res.
.2014
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| 111. |
2014
Jayakumar, T.,Chiu, C.C.,Wang, S.H.,Chou, D.S.,Huang, Y.K.,Sheu, J.R..
Anticancer effect of CME-1, a novel polysaccharide, purified from the Mycelia of Cordyceps sinensis against B16F10 melanoma cells.
. J. Cancer Res. Ther. DOI: 10.4103/0973-1482.131365.
.2014
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| 112. |
2014
Chang, C.C.,Duann, Y.F.,Yen, T.L.,Chen, Y.Y.,Jayakumar, T.,Ong, E.T., Sheu, J.R..
Inhibitory action of andrographolide, a novel NF-B inhibitor, in vascular smooth muscle cell proliferation and cerebral endothelial cell dysfunction.
. Acta Cardiol. Sinica
.2014
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| 113. |
2014
Lu, W.J,Lin, S.C.,Lan, C.C.,Lee, T.Y.,Hsia, C.H.,Huang, Y.K., Lee, H.C., Sheu, J.R..
Effect of Antrodia camphorata in inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.
. Sci. World J.DOI:10.1155/2014/745802
.2014
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| 114. |
2014
Jayakumar, T.,Elizebeth, A.R.,Yen, T.L.,Sheu, J.R..
Chinese medicine and bioactive coumponds for the treatment of stroke
. Chin. J. Integr. Med. DOI:10.1007/s11655-014-1782-2
.2014
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| 115. |
2014
Lu, W.J.,Chang, N.C.,Jayakumar, T.,Liao, J.C.,Lin, M.J.,Wang, S.H., Chou, D.S., Thomas, P.A., Sheu, J.R..
Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP.
. Thromb. Res. doi: 10.1016/j.thromres.2014.09.023.
.2014
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| 116. |
2014
Lu, W.J.,Chang, N.C.,Jayakumar, T.,Liao, J.C.,Lin, M.J.,Wang, S.H., Chou, D.S., Thomas, P.A., Sheu, J.R..
Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP.
. Thromb. Res. doi: 10.1016/j.thromres.2014.09.023.
.2014
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| 117. |
2014
Yen, T.L.,Ong, E.T.,Lin, K.H.,Chang, C.C.,Jayakumar, T.,Lin, S.C., Fong, T.H., Sheu, J.R..
Potential advantages of Chinese medicine Taohong Siwu Decoction combined with tissue-plasminogen activator for alleviating middle cerebral artery occlusion-induced embolic stroke in rats
. Chin. J. Integr. Med.
.2014
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| 118. |
2013
Jayakumar, T.,Chiu, C.C.,Wang, S.H.,Chou, D.S.,Huang, Y.K.,Sheu, J.R..
Anticancer effect of CME-1, a novel polysaccharide, purified from the Mycelia of Cordyceps sinensis against B16F10 melanoma cells.
. J. Cancer Res. Ther. (in press).
.2013
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| 119. |
2013
Jayakumar, T.,Hsu W.H.,Yen T.L.,Luo J.Y.,Kuo, Y.C.,Fong, T.H., Sheu, J.R..
Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo.
. Evid. Based Complement Alternat. Med. article ID 840487, 8 pages, doi:10.1155/2013/840487.
.2013
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| 120. |
2013
Chang, C.C.,Duann, Y.F.,Yen, T.L.,Chen, Y.Y.,Jayakumar, T.,Ong, E.T., Sheu, J.R..
Inhibitory action of andrographolide, a novel NF-B inhibitor, in vascular smooth muscle cell proliferation and cerebral endothelial cell dysfunction.
. Acta Cardiol. Sinica (in press).
.2013
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| 121. |
2013
Lu, W.J.,Wu, M.P.,Lin, K.H.,Lin, Y.C.,Chou, H.C.,Sheu, J.R..
Hinokitiol is a novel glycoprotein VI antagonist on human platelets.
. Platelets (in press)
.2013
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| 122. |
2013
Wang MJ,Chang WJ,Lee WF,Lee SY,Sheu JR,Teng NC.
The effects of funoran-containing xylitol chewing gum on dental plaque
. J Polym Eng
.2013
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| 123. |
2013
Lin, K.H.,Kuo, J.R.,Lu, W.J.,Chung, C.L.,Chou, D.S.,Huang, S.Y., Lee, H.C., Sheu, J.R..
Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo.
. Biochem. Pharmacol.
.2013
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| 124. |
2013
Thanasekaran, J,Hsieh, C.Y.,Lee, J.J.,Sheu, J.R..
Experimental and clinical pharmacology of Andrographispaniculata and its major bioactive phytoconstituent andrographolide.
. Evid Based Complement Alternat Med.ID 846740, doi: 10.1155/2013/846740
.2013
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| 125. |
2013
Chang Y,Chen WF,Lin KH,Hsieh CY,Chou DS,Lin LJ, Sheu JR, Chang CC.
Novel bioactivity of ellagic acid in inhibiting human platelet activation.
. Evid Based Complement Alternat Med.2013:595128. doi: 10.1155/2013/595128
.2013
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| 126. |
2013
Chen, Y.Y.,Hsu, M.J.,Sheu, J.R.,Lee, L.W.,Hsieh, C.Y..
Andrographolide, a novel NF-κB inhibitor, induces vascular smooth muscle cell apoptosis via a ceramide-p47phox-ROS signaling cascade.
. Evid. Based Complement Alternat. Med. 2013:821813. doi: 10.1155/2013/821813.
.2013
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| 127. |
2013
Yi Chang,Steven Kuan-Hua Huan,Wan-Jung Lu,Chi-Li Chung,Wei-Lin Chen,Shun-Hua Lu,Kuan-Hung Lin,Joen-Rong Sheu.
Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets
. Journal of Biomedical Science. 20: 4. doi: 10.1186/1423-0127-20-4
.2013
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| 128. |
2013
Ting-Lin Yen,Wen-Hsien Hsu,Steven Kuan-Hua Huan,Wan-Jung Lu,Chao-Chien Chang,Li-Ming Lien,George Hsiao,Joen-Rong Sheu,Kuan-Hung Lin.
A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis
. Pharm Biol
.2013
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| 129. |
2013
Lin PH,Yeh SK,Huang WC,Chen HY,Chen CH,Sheue JR, Lin CT, Huang YK.
Research Performance of Biomarkers from Biofluids in Periodontal Disease Publications
. Journal of Dental Sciences
.2013
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| 130. |
2013
Chen, W.F.,Lee, J.J.,Chang, C.C.,Lin, K.H.,Wang, S.H.,Sheu, J.R..
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets.
. Haematologica.
.2013
;(98):793-801
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| 131. |
2013
Jayakumar, T.,Chen, W.F.,Lu, W.J.,Chou, D.S.,Hsiao, G.,Hsu, C.Y., Sheu, J.R.Hsieh, C.Y..
A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies.
. J. Nutr. Biochem.
.2013
;(24):1086-1095
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| 132. |
2012
Chang, C.C.,Lu, W.J.,Ong, E.T.,Chiang, C.W.,Lin, S.C.,Huang, S.Y., Sheu, J.R..
A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation.
. J. Biomed. Sci. doi:10.1186/1423-0127-18-93.
.2012
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| 133. |
2012
Wang JJ,Huan SKH,Hsieh KH,Chou HC,Hsiao G,Thanasekaran J, Sheu JR.
Inhibitory effect of midazolam on MMPs-9,-1 and 13 expression in PMA-stimulated human articular chondrocyte through recovering of NF-kB signaling
. Arch Med Sci (in press)
.2012
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| 134. |
2012
Sheu, J.R.,Jayakumar, T.,Chang, C.C.,Priya, S.,Ong, E.T.,Chen, Y.C., Elizebeth, A.R..
Pharmacological Actions of an Ethanolic Extracts of the Leaves Hemigraphis colorata and Clerodendron phlomoides.
. Clin Mol. Med.
.2012
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| 135. |
2012
Lien, L.M.,Su, C.C,Hsu, W.H.,Lu, W.J.,Chung, C.L.,Yen, T.L., Chiu, H.C., Sheu, J.R., Lin, K.H..
Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway.
. Phytother. Res. doi: 10.1002/ptr.4911.
.2012
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| 136. |
2012
Yen TL,Hsu CK,Lu WJ,Hsieh CY,Hsiao G,Chou DS,Wu GJ,Sheu JR.
Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (Humulus Lupulus), in ischemic stroke of rats.
. J. Agric. Food Chem.
.2012
;(60):1937-1944
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| 137. |
2012
Lee YM,Hsieh KH,Lu WJ,Chou HC,Chou DS,Lien LM,Sheu JR,Lin KL.
Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets.
. Evid-Based Complement Alternat Med. doi:10.1155/2012/852362
.2012
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| 138. |
2012
Lu, W.J.,Lin, K.H.,Hsu, M.J.,Chou, D.S.,Hsiao, G.,Sheu, J.R..
Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.
. Biochem. Pharmacol.
.2012
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| 139. |
2012
Lu, Y.C.,Hsiao, G.,Lin, K.H.,Hsieh, M.S.,Jayakumar, T.,Wu, T.S., Sheu, J.R..
Cinnamophilin isolated from Cinnamomum philippinense protects against collagen degradation in human chondrocytes.
. Phytother. Res. doi: 10.1002/ptr.4812.
.2012
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| 140. |
2012
Mangindaan, D,Yared, I.,Kurniawan, H.,Sheu, J.R.,Wang. M.J..
Modulation of biocompatibility on poly(vinylidene fluoride) and polysulfone by oxygen plasma treatment and dopamine coating.
. J. Biomed. Mater. Res. A.
.2012
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| 141. |
2012
Shen, M.Y.,Lin, Y.P.,Yang, B.C.,Jang, Y.S.,Chiang, C.K.,Mettling, C., Chen, Z.W., Sheu, J.R., Chang, C.L., Lin, Y.L., Yang, W.C..
Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways.
. Evid Based Complement Alternat Med.
.2012
;(2012):982396
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| 142. |
2011
Jayakumar, T.,Thomas, P.A.,Sheu, J.R.,Geraldine, P..
In-vitro and in-vivo antioxidant effects of the oyster mushroom Pleurotus ostreatus.
. Food Res. Int.
.2011
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| 143. |
2011
Lu, Y.C.,Jayakumar, T.,Duann, Y.F.,Chou, Y.C.,Hsieh, C.Y.,Yu, S.Y., Sheu, J.R., Hsiao, G..
Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW-1353 cells.
. J. Agri. Food Chem.
.2011
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| 144. |
2011
Lee, Y.M.,Cheng, P.Y.,Chim, L.S.,Kung, C.W.,Ka, S.M.,Chung, M.T., Sheu, J.R..
Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses.
. J. Ethnopharmacol.
.2011
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| 145. |
2011
Jayakumar, T.,Sheu, J.R..
Cardiovascular pharmacological actions of rutaecarpine, a quinazolinocarboline alkaloid isolated from Evodia rutaecarpa.
. J. Exp. Clin. Med.
.2011
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| 146. |
2011
Lu, W.J.,Lee, J.J.,Chou, D.S.,Jayakumar, T.,Fong, T.H.,Hsiao, G., Sheu, J.R..
A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP.
. J. Mol. Med.
.2011
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| 147. |
2011
Chou, Y.C.,Sheu, J.R.,Chung, C.L.,Hsiao, C.J.,Hsueh. P.J.,Hsiao. G..
Hypertonicity-enhanced TNF-α release from activated human monocytic THP-1 cells requires ERK activation.
. Biochim. Biophys. Acta.
.2011
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| 148. |
2011
Lee, Y.M.,Cheng, P.Y.,Chen, S.Y.,Chung, M.T.,Sheu, J.R..
Wogonin Suppresses Arrhythmias, Inflammatory Responses and Apoptosis Induced by Myocardial Ischemia/Reperfusion in Rats.
. J. Cardiovasc. Pharmacol.
.2011
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| 149. |
2011
Wu, C.J.,Chou, Y.C.,Cheng, Y.W.,Hsiao, C.J.,Wang, C.H.,Wang, H.Y., Sheu, J.R, Hsiao, G..
Aristolochic acid downregulates monocytic matrix metalloproteinase-9 by inhibiting nuclear factor-κB activation.
. Chem-Biol. Interact.
.2011
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| 150. |
2011
Hsieh, K.H.,Lee, J.J.,Lee, L.W.,Sheu, J.R.,Hwang S.T.,Chou, D.S..
Evaluation of antioxidants using an arachidonic acid-stiumlated platelet electron spin resonance system.
. J. Food Drug Anal.
.2011
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| 151. |
2011
Hsu, W.H.,Chang, W.W.,Sheu, J.R.,Hsiao, Y.K.,Tsai, Y.J.,Chou, D.S..
Studies on the inhibitory mechanisms of baicalein in B16F10 melanoma cell proliferation.
. J. Food Drug Anal.
.2011
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| 152. |
2011
Chang, Y.,Uen, Y.H.,Chen, C.C.,Lin, S.C.,Tseng, S.Y.,Wang, Y.H., Sheu, J.R., Hsieh, C.Y..
The inhibitory effect of platonin on PDGF-BB-induced vascular smooth muscle cell proliferation: the pivotal role of JNK1/2-dependent signaling.
. Acta Pharmacol. Sinica
.2011
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| 153. |
2011
Hsu, Y.F.,Sheu, J.R.,Lin, C.H.,Chen, W.C.,Hsiao, G.,Ou, G., Chiu, P.T., Hsu, M.J..
MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide.
. Biochim. Biophys. Acta.
.2011
;(1810):1160-1169
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| 154. |
2011
Chang, Y.,Lee, J.J.,Chen, W.F.,Chou, D.S.,Huang, S.Y.,Sheu, J.R..
A novel role of inhibition of platelet activation by tamoxifen in washed human platelets.
. Transl. Res.
.2011
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| 155. |
2011
Wu, C.J.,Chen, J.T.,Yen, T.L.,Jayakumar, T.,Chou, D.S.,Hsiao, G., Sheu, J.R..
Neuroprotection by the traditional Chinese medicine, Tao-Hong-Si-Wu-Tang, against middle cerebral artery occlusion (MCAO)-induced cerebral ischemia in rats.
. Evid-Based Compl. Alt. Med. doi:10.1155/2011/803015.
.2011
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| 156. |
2011
Hsieh CY,Hsu MJ,Hsiao G,Wang YH,Huang CW,Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu J.R.
Andrographolide enhances NF-κB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A (PP2A) in vascular smooth muscle cells.
. Journal of Biological Chemistry
.2011
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| 157. |
2011
Lee JJ,Hsu WH,Yen TL,Chang NC,Luo YJ,Hsiao G, Sheu JR.
Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats.
. J Ethnopharmacol.
.2011
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| 158. |
2010
Chou, Y.C.,Sheu, J.R.,Chung, C.L.,Chen, C.Y.,,Lin, F.L.,Hsu, M.J., Kuo, Y.H., Hsiao, G..
Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells.
. Chem-Biol. Interact.
.2010
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| 159. |
2010
144. Chang, C.C.,Lee, J.J.,,Chiang, C.W.,Jayakumar, T.,Hsiao, G.,Hsieh, C.Y., Sheu, J.R..
Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: the pivotal role of PKC-α translocation.
. Pharma. Biol.
.2010
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| 160. |
2010
Shiue, H.S.,Lee. Y.S.,Tsai, C.N.,Hsueh, Y.M.,Sheu, J.R.,Chang, H.H..
Gene expression profile of patients with phadiatop-positive and -negative allergic rhinitis treated with acupuncture
. J. Altern. Complement Med.
.2010
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| 161. |
2010
Lee, Y.M.,Chen, W.F.,Chou, D.S.,Jayakumar, T.,Ho, S.Y.,Lee, J.J., Hsiao, G., Sheu, J.R..
Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation.
. J. Biomed. Sci. 17:45; doi:10.1186/1423-0127-17-45
.2010
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| 162. |
2010
Hsieh, C.Y.,Liu, C.L.,Hsu, M.J.,Jayakumar, T.,Chou, D.S.,Wang, Y.H., Hsiao, G., Sheu, J.R.
Inhibition of vascular smooth muscle cell proliferation of vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation.
. Free Radic. Biol. Med.
.2010
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| 163. |
2010
Wu, G.J.,Lee, J.J.,Chou, D.S.,Jayakumar, T.,Hsiao, G.,Chen, W.F., Sheu, J.R..
Inhibitory signaling of 17β-estradiol in platelet activation: the pivotal role of cyclic AMP-mediated nitric oxide synthase activation.
. Eur. J. Pharmacol.
.2010
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| 164. |
2010
Lin, K.H.,Chang, Y.F.,Fan, C.Y.,Jayakumar, T.,Lee, J.J.,Chou, D.S., Hsiao, G., Sheu, J.R..
Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase Cγ2-protein kinase C-p38 MAPK cascade.
. Trans. Res.
.2010
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| 165. |
2010
Chang, C.C.,Lu, W.J.,Chiang, C.W.,Hsiao, G.,Fong, T.H.,Chou, D.S., Sheu, J.R..
Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase.
. J. Nutr. Biochem.
.2010
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| 166. |
2009
Lin, K.H.,Chang, H.C.,Lu, W.J.,Jayakumar, T.,Chou, H.C.,Fong, T.H., Hsiao, G., Sheu, J.R..
Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents.
. Platelets (in press)
.2009
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| 167. |
2009
Chang, C.C.,Lee, J.J.,Chiang, C.W.,Jayakumar, T.,Hsiao, G.,Hsieh, C.Y., Sheu, J.R..
Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: the pivotal role of PKC-α translocation.
. Pharma. Biol. ( in press)
.2009
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| 168. |
2009
Hsu, M.J.,Sheu, J.R.,Lin, C.H.,Shen, M.Y.,Hsu, C.Y..
Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration.
. Biochim Biophys Acta. (in press).
.2009
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| 169. |
2009
Wu, C.J.,Hsieh, C.Y.,Hsiao, G.,Chou, D.S.,Sheu, J.R..
Triflavin, an II3 disintegrin, inhibits cell adhesion and protein kinase C-alpha translocation in vascular smooth muscle cells.
. Pharma. Biol.
.2009
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| 170. |
2009
Chang, Y.,Lee, J.J.,Hsieh, C.Y.,Hsiao, G.,Chou, D.S.,Sheu, J.R..
Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation.
. Mediators Inflamm.
.2009
;(2009):705379
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| 171. |
2009
Chou, D.S.,Hsiao, G.,Lai, Y.A.,Tsai, Y.J.,Sheu, J.R..
Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase.
. Free Radic. Biol. Med.
.2009
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| 172. |
2009
Lin, K.H.,Hsiao, G.,Shih, C.M.,Chou, D.S.,Sheu, J.R..
Mechanisms of resveratrol-induced platelet apoptosis.
. Cardiovasc. Res.
.2009
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| 173. |
2009
Ho, S.C.,Lee, K.Y.,Chan, Y.F.,Kuo, L.W.,Ito, K.,Adcock, I.M., Chen, B.C., Sheu, J.R., Lin. C.H., Kuo HP..
Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-B repressing factor.
. J. Immunol.
.2009
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| 174. |
2009
Chang, Y.,Hsieh, C.Y.,Peng, Z.A.,Yen, T.L.,Hsiao, G.,Chou, D.S., Chen, C.M., Sheu, J.R..
Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats.
. J. Biomed. Sci. (in press)
.2009
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| 175. |
2008
Chamg TH,Liu CL,Lin KH,Lin MN,Hsiao G,Sheu JR.
Neuroprotective Effects of Acetylsalicylic Acid in Middle Cerebral Artery Occlusion-induced Brain Ischemia in Rats: Suppressed the iNOS, HIF-1alpha, TNF-alpha, and Active Caspase-3 Expressions
. Pharm. Biol. (in press)
.2008
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| 176. |
2008
Shen MY,Hsiao G,Fong TH,Chou DS,Sheu JR.
Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cγ2-protein kinase C pathway in platelet activation
. Pharmacological Research
.2008
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| 177. |
2008
Shen, M.Y,Hsiao, G.,Fong, T.H.,Chen, H.M.,Chou, D.S.,Lin, C.H., Sheu, J.R..
Amyloid beta peptide-activated signal pathways in human platelets.
. Eur. J. Pharmacol.
.2008
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| 178. |
2008
Shen, M.Y.,Liu, C.L.,Hsiao, G.,Liu, C.Y.,Lin, K.H.,Chou, D.S., Sheu, J.R..
Involvement of p38 MAPK phosphorylation and nitrate Formation in aristolochic acid-mediated antiplatelet activity.
. Planta. Med.
.2008
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| 179. |
2008
Chung, C.L.,Chen, C.H.,Yeh, C.Y.,Sheu, J.R.,Chang, S.C..
Early effective drainage in the treatment of loculated tuberculous pleurisy.
. Eur. Respir. J.
.2008
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| 180. |
2008
Chung, C.L.,Sheu, J.R.,Liu, H.E.,Chang, S.C.,Chou, Y.C.,Chen, W.L., Chou, D.S., Hsiao, G..
Dynasore, a dynamin inhibitor, induces PAI-1 expression in MeT-5A human pleural mesothelial cells.
. Am. J. Resp. Cell Mol. (in press)
.2008
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| 181. |
2008
Shyu, K.G,Huang, W.C.,Tai, P.A.,Hsiao, G.,Chou, D.S.,Lee, L.W., Chen, J.S., Sheu, J.R..
Inhibitory effects of lycopene on the induction of NO, cytokines, and mitogen-activated protein kinase expressions by lipopolysaccharide in primary cultured microglia.
. Pharma. Biol.
.2008
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| 182. |
2007
Hsiao, G.,Lee, J.J.,Chen, Y.C.,Lin, J.H.,Shen, M.Y.,Lin, K.H., Chou, D.S., Sheu, J.R..
Neuroprotective effects of PMC, a potent -tocopherol derivative, in brain ischemia-reperfusion: Reduced neutrophil activation and anti-oxidant actions.
. Biochem. Pharmacol.
.2007
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| 183. |
2007
Chen, T.G.,Lee, J.J.,Lin, K.H.,Shen, C.H.,Chou, D.S.,Sheu, J.R..
Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets.
. Chin. J. Physiol.
.2007
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| 184. |
2007
Hsiao G,Lee JJ,Lin KH,Shen CH,Fong TH,Chou DS, S heu JR.
Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies
. Cradiovascular Research
.2007
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| 185. |
2007
Shen MY,Hsiao G,Liu CL,Fong TH,Lin KH,Chou DS, Sheu JR.
Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP
. British Journal of Haematology
.2007
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| 186. |
2007
Chang Y,Hsiao G,Chen YC,Lin JH,Lin KH,Chou DS, Sheu JR.
Tetramethylpyrazine suppresses the HIF-1, TNF-, and active caspase-3 expressions in middle cerebral artery occlusion-induced brain ischemia in rats
. Acta Pharmacol. Sin
.2007
;(28):327-333
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| 187. |
2007
Pan CF,Shen MY,Wu CJ,Hsiao G,Chou DS,Sheu JR.
Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation
. Journal of Pharmacy and Pharmacology
.2007
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| 188. |
2007
Chou DS,Lee JJ,Hsiao G,Hsieh CH,Tsai YJ,Chen TF, Sheu JR.
Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study
. J. Agric.Food Chem
.2007
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| 189. |
2006
Wu, C.J.,Sheu, J.R.,Chen, H.H.,Liao, H.F.,Yang, Y.C.,Yang, S., Chen, Y.J..
Modulation of monocyte-derived dendritic cell differentiation is associated with Ischemic acute renal failure.
. J. Surg. Res.
.2006
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| 190. |
2006
Wu, C.J.,Sheu, J.R.,Chen, H.H.,Liao, H.F.,Yang, Y.C.,Yang, S., Chen, Y.J..
Renal ischemia/reperfusion injury inhibits differentiation of dendritic cells derived from bone marrow monocytes in rats.
. Life Sci.
.2006
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| 191. |
2006
Chen, B.C.,Liao, C.C.,Hsu, M.J.,Liao, Y.T.,Lin, C.C.,Sheu, J.R., Lin, C.H..
Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B.
. J. Immunol.
.2006
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| 192. |
2006
Chou, D.S.,Lee, J.J.,Hsiao, G.,Hsieh, C.Y.,Tsai, Y.J.,Chen, T.F., Sheu, J.R..
Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study.
. J. Agri. Food Chem.
.2006
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| 193. |
2006
Chou, D.S.,Chan, C.H.,Hsiao, G.,Shen, M.Y.,Tsai, Y.J.,Chen, T.F., Sheu, J.R..
Inhibitory Mechanisms of low concentrations of oxidized low-density lipoprotein on platelet aggregation.
. J. Biomed. Sci.
.2006
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| 194. |
2006
Hsiao, G.,Chen, Y.C.,Lin, J.H.,Lin, K.H.,Chou, D.S.,Lin, C.H., Sheu, J.R..
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
. Planta Medica
.2006
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| 195. |
2006
Lee, Y.M.,Lee, J.J.,Shen, M.Y.,Hsiao, G.,Sheu, J.R..
Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation.
. Eur. J. Pharmacol.
.2006
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| 196. |
2006
Chang, Y.,Hsiao, G.,Chen, S.H.,Chen, Y.C.,Lin, J.H.,Lin, K.H., Chou, D.S., Sheu, J.R..
Tetramethylpyrazine suppresse4s the HIF-1, TNF-, and active caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats.
. Acta Pharmacol. Sinica
.2006
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| 197. |
2005
Chang, Y.,Chen, T.L.,Sheu, J.R.,Chen, R.M..
Suppressive effects of ketamine on macrophage functions.
. Toxicol. Appl. Pharmacol.
.2005
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| 198. |
2005
Hsiao, G.,Wany Y,Tzu NH,Fong TH,Shen MY,Lin KH, Chou DS, Sheu JR.
Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation.
. J. Lab. Clin. Med.
.2005
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| 199. |
2005
Chou DS,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR.
ESR spin-trapping of a carbon-centered free radical from agonist-stimulated human platelets.
. Free Rad. Biol. Med.
.2005
;(39):237-248
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| 200. |
2005
Hsiao G,Lin KH,Chang Y,Chen TL,Tzu NH,Chou DS, Sheu JR.
Protective mechanisms of inosine in platelet activation and cerebral ischemic damage.
. Arterioscl. Thromb. Vas. Biol.
.2005
;(25):1998-2004
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| 201. |
2005
Hsiao G,Chang CY,Shen MY,Chou DS,Tzeng SH,Chen TF, Sheu JR.
Alpha-naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation.
. J. Agri. Food Chem.
.2005
;(53):5179-5186
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| 202. |
2005
Hsiao G,Chou PH,Shen MY,Chou DS,Lin CH,Sheu JR.
C-Phycocyanin, a Very Potent and Novel Platelet Aggregation Inhibitor from Spirulina platensis.
. J. Agri. Food Chem.
.2005
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| 203. |
2005
Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF, Sheu JR.
Inhibitory Mechanisms of Low Concentrations of Oxidized Low-Density Lipoprotein on Platelet Aggregation.
. J. Biomed. Sci.
.2005
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| 204. |
2005
Hsiao G,Chen YC,Lin JH,Lin KH,Chou DS,Lin CH, Sheu JR.
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
. Planta Medica (in press)
.2005
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| 205. |
2004
Chou, D.S.,Hsiao, G.,Shen, M.Y.,Fong, T.H.,Lin, C.H.,Chen, T.F., Sheu, J.R..
Low Concentration of Oxidized Low-Density Lipoprotein Suppresses Platelet Reactivity In Vitro: an Intracellular Study.
. Lipids
.2004
;(39):433-440
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| 206. |
2004
Hsiao, G.,Shen, M.Y.,Chou, D.S.,Lin, C.H.,Sheu, J.R..
The antiplatelet activity of magnesium sulfate involved suppression of protein kinase C and Na+/H+ exchanger.
. J. Biomed. Sci.
.2004
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| 207. |
2004
Sheu, J.R.,Fong, T.H.,Liu, C.M.,Shen, M.Y.,Chen, T.L.,Chang, Y., Lu, M.S., Hsiao G..
The release and expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in vitro and in vivo studies.
. Br. J. Pharmacol.
.2004
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| 208. |
2004
Sheu, J.R.,Hsiao G.,Chou, P.H.,Shen, M.Y.,Chou, D.S..
Mechanisms Involved in the Antiplatelet Activity of Rutin, a Glycoside of the Flavonol Quercetin, in Human Platelets.
. J. Agri.Food Chem.
.2004
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2004
Chang, Y.,Chen, T.L.,Hsiao, G.,Shen, M.Y.,Lin, K.H.,Chou, D.S., Lin, C.H., Sheu, J.R..
The Antiplatelet activity of ketamine is mediated through suppression of phosphoinositide breakdown and an increase in cyclic GMP.
. J. Biomed Sci.
.2004
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| 210. |
2004
Hsiao, G.,Fong, T.H.,Tzu, N.H.,Lin, K.H.,Chou, D.S.,Sheu, J.R..
A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats.
. In ViVo
.2004
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| 211. |
2004
Chen, B.C.,Chang, Y.S.,Kang, J.C.,Hsu, M.J.,Sheu, J.R.,Chen, T.L., Teng, C.M., Lin, C.H..
Peptidoglycan induces nuclear factor-kB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages.
. J. Biol Chem.
.2004
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2004
Hsiao G,Huang, H.Y,Fong, T.H.,Shen, M.Y.,Lin, C.H.,Teng, C.M., Sheu, J.R..
Inhibitory mechanisms of PMC and YC-1 in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages.
. Biochem. Pharmacol.
.2004
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2004
Hsiao, G.,Shen, M.I.,Chou, D.S.,Chang, Y.,Lee, L.W.,Lin, C.H., Sheu, J.R..
Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies.
. Eur. J. Pharmacol.
.2004
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2003
Sheu, J.R., Hsiao, G., Shen, M.Y., Lee, Y.M., Yen, M.H..
Antithrombotic effects of magnesium sulfate in in vivo experiments.
. Int. J. Hematol.
.2003
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| 215. |
2003
Chuang, W.J., Wu, C.H., Huang, H.N., Wu, C.H., Hsiao, G., Lin, C.H., Sheu, J.R..
Triflavin, an Arg-Gly-Asp-containing disintegrin, binds effectively to resting and activated aIIbb3 integrin in human platelets.
. Thromb. Res.
.2003
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2003
Hsiao, G., Shen, M.Y., Fang, C.L., Chou, D.S., Lin, C.H., Sheu, J.R..
Morphine-potentiated platelet aggregation in in vivo and platelet plug formation in in vivo experiments.
. J. Biomed. Sci.
.2003
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2003
Hsiao, G., Shen, M.Y., Lin, K.H., Lan, M.H., Wu, L.Y., Chou, D.S., Lin, C.H., Sheu, J.R..
Antioxidative and hepatoprotective effects of Antrodia Camphorata Extract.
. J. Agri.Food Chem.
.2003
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2003
Chen, R.M., Wu, C.H., Chang, H.C., Wu, G. J., Lin, Y.L., Sheu, J.R., Chen, D.L..
Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis.
. Anesthesiology
.2003
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2003
Wu, C.J., Sheu, J.R., Chen H.H., Shyur, S.D., Chen, P.G., Chen, Y.J..
Anti-leukemic immunity against U937 cells in uremic patients.
. Neoplasma
.2003
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2003
Wang, T.M., Chiang, C.E., Sheu, J.R., Tsou, C.H., Chang, H. M., Luk, H.N..
Homogenous distribution of fast response action potentials in canine pulmonary vein sleeves: a contradictory report.
. Int. J. Cardiol.
.2003
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2003
Hsaio G, Shen MY, Chang WC, Cheng YW, Pan SL, Kuo YH, *Sheu JR.
A novel antioxidant, octyl caffeate, suppressed LPS/IFN-g-induced iNOS gene expression in rat aortic smooth muscle cells.
. Biochem. Pharmacol.
.2003
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2003
Lee YM,Hsiao G,Chang JW,Sheu JR,Yeh MH.
Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells.
. J. Biomed. Sci.
.2003
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2003
Sheu JR,Hsiao G,Shen MY,Wang Y,Lin KH,Lin CH, Chou DS.
Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments.
. Exp. Biol. Med.
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2003
Hsaio G,Shen MY,Chou CY,Tzu NH,Lin CH,Chou DS, Sheu JR.
Inhibitory activities of kinetin in free radical formation of activated platelets in vitro and thrombus formation in vivo.
. Eur. J. Pharmacol.
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2003
Kuo CS,Chiang LL,Lee CN,Yu MT,Pei KZ,Lee HM, Lee WS, Sheu JR, Lin CH.
Induction of inducible nitrin oxide synthase in RAW 264.7 macrophages by lipoteichoic acid derived from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms.
. J. Biomed.
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2003
Kuo, C.S., Chiang, L.L., Lee, C.N., Yu, M.T., Pei, K.Z., Lee, H.M., Lee, W.S., Sheu, J.R., Lin, C.H..
Induction of inducible nitrin oxide synthase in RAW 264.7 macrophages by lipoteichoic acid derived from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms.
. J. Biomed. Sci.
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| 227. |
2003
78. Sheu, J.R., Hsiao, G., Shen, M.Y., Chou, C.Y., Lin, C.H., Chen, T.O., Chou, D.S..
Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation.
. Platelets
.2003
;(14):189-196
|
|
| 228. |
2002
Chang MS, Lee WS, Teng CM, Lee HM, Sheu JR, Hsiao G, Lin CH.
YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells.
. Br. J. Pharmacol.
.2002
;(136):558-576
|
|
| 229. |
2002
Hsiao G, Lee JJ, Chou DS, Fong TH, Shen MY, Lin CH, Sheu JR.
Platonin, a photosensitizing dye, improves circulatory failure and mortality in rat models of endotoxaemia.
. Biol. Pharmaceut. Bullet.
.2002
;(25):995-999
|
|
| 230. |
2002
Lin CH, Kuan IH, Wang CH, Lee HM, Lee WS, Sheu JR, Hsiao G, Wu CH, Kuo HP.
Lipoteichoic acid-induced cyclooxygenase-2 express in human pulmonary epithelial cells requires activation of p44/42 and p38 MAPK signal pathways.
. Eur. J. Pharmacol.
.2002
;(450):1-9
|
|
| 231. |
2002
Ching CE, Luk HN, Wang TM, Sheu JR, Ding PYA.
Genistein and tyrphostin AG 556 block the action potential shortening in septic shock.
. Chin. Med. J.
.2002
;(65):570-579
|
|
| 232. |
2002
Sheu JR, Yeh GC, Fang CL, Lin CH, Hsiao G.
Morphine potentiated agonist-induced platelet aggregation through a2-adrenoceptors in human platelets.
. J. Cardiovasc. Pharmacol.
.2002
;(40):743-750
|
|
| 233. |
2002
Sheu JR, Hsiao G, Shen MY, Fong TH, Chen YW, Lin CH, Chou DS.
Mechanisms involved in the antiplatelet activity of magnesium in human platelets.
. Br. J. Haematol.
.2002
;(119):1033-1041
|
|
| 234. |
2002
Sheu JR, Hsiao G, Shen MY, Lin WY, Tzeng CR..
The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways
. Clin. Lab. Haematol.
.2002
;(24):121-129
|
|
| 235. |
2002
Hsiao G, Yen MH, Lee YM, Sheu JR.
Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo
. Br. J. Haematol
.2002
;(117):699-704
|
|
| 236. |
2002
Lee PY,Yeh HI,Hou CJY,Chou YS,Tsai CH,Sheu JR.
Comparison of clinical features and outcome in massive and non-massive pulmonary embolism.
. Acta Cardiol. Sin.
.2002
;(18):173-180
|
|
| 237. |
2002
Lee YM, Chen HR, Hsiao G, Sheu JR, Wang JJ, Yen MH.
Protective effects of melatonin on myocardical ischemia/reperfusion injury in vivo
. J. Pinral Res
.2002
;(32):1-9
|
|
| 238. |
2002
Sheu JR, Hsiao G, Luk HN, Chen YW, Chen TL, Lee LW, Lin CH, Chou DS..
Mechansims involved in the antiplatelet activity of midazolam in human platelets
. Anesthesiology
.2002
;(96):651-8
|
|
| 239. |
2002
Sheu JR, Hsiao G, Lin WY, Chen TF, Chien YY, Lin CH, Tzeng CR.
Mechanisms involved in agonist-induced hyperaggregability of platelets from normal pregnancy
. J. Biomed. Sci.
.2002
;(9):17-25
|
|
| 240. |
2001
Hsiao G., Lin YH, Lin CH, Chou DS, Lin WC, Sheu JR.
The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo
. Biol. Pharmaceutical Bullet
.2001
;(24):1271-1276
|
|
| 241. |
2001
Lin CH,Kuan IH,Lee HM,Lee WS,Sheu JR,Ho YS, Wang CH, Kuo HP.
Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus of in human pulmonary epithelial cells: involvement of a nuclear factor-kB-dependent pathway.
. Br. J. Pharmacol.
.2001
;(134):543-552
|
|
| 242. |
2001
Lee YM, Hsiao G, Chen HR, Chen YC, Sheu JR, Yen MH..
Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats
. Eur. J. Pharmacol
.2001
;(422):159-167
|
|
| 243. |
2001
Lin CH, Sheu SY, Lee HM, Ho YS, Lee WS, Ko WC, Sheu JR..
Involvement of protein kinsas C in IL-1b-induced cyclooxygenase-2 expression in human pulmonary epithelial cells.
. Mol. Pharmacol.
.2001
;(57):36-43
|
|
| 244. |
2001
Wu CH, Chen YC, Hsiao G, Lin CH, Liu CM, Sheu JR..
Mechanisms involved in the inhibition of neointimal hyperplasia by abciximab in a rats model of balloon angioplasty.
. Thromb. Res.
.2001
;(101):127-138
|
|
| 245. |
2001
Sheu JR, Hsiao G, Lee YM, Yen MH..
Antithrombotic effects of tetramethylpyrazine in in vivo experiments.
. Int. J. Hematol. (in press)
.2001
;(73):393-398
|
|
| 246. |
2001
Sheu JR, Wu CH, CHen YC, Hsiao G, Lin CH..
Mechanisms involved in the inhibition of neointimal hyperplasia by triflavin in a rats model of balloon angioplasty.
. J. Lab. Clin. Med.
.2001
;(137):270-278
|
|
| 247. |
2000
Sheu JR, Kan YC, Hung WC, Lin CH, Yen MH..
Tetramethylpyrazine, a naturally occurring ecNO synthase activator in human platelets.
. Life Sci.
.2000
;(67):937-947
|
|
| 248. |
2000
Sheu JR, Hung WC, Wu CH, Lee YM, Yen MH.
Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa on platelet plug formation in in vivo experiments.
. Br. J. Haematol.
.2000
;(110):110-115
|
|
| 249. |
2000
Sheu JR, Lee CR, Lin CH, Hsiao G, Ko WC, Chen YC, Yen MH..
Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets.
. Thrombos. Haemostas.
.2000
;(83):777-784
|
|
| 250. |
2000
Sheu JR, Hsiao G, Lee CR, Lee LW, Su CH, Lin CH..
Antiplatelet activity of Staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway.
. Thromb. Res.
.2000
;(99):249-258
|
|
| 251. |
2000
Lee YM, Yen MH, Peng YY, Sheu JR, Chen YC, Chang MJ, Cheng CY..
The antihypertensive and cardioprotective effects of (-)-MJ-451, an ATP-sensitive K+ channel opener.
. Eur. J. Pharmacol.
.2000
;(397):151-160
|
|
| 252. |
2000
Hsiao G, Teng CM, Sheu JR, Cheng YW, Lam KK, Lee YM, Yen MH..
Cinnamophilin as a novel antiperoxidative cytoprotectant and free radical scavenger.
. Biochem. Biophys. Acta
.2000
;(25128):1-12
|
|
| 253. |
1999
Sheu JR, Lee CR, Lin CC, Kan YC, Lin CH, Hung WC, Lee YM and Yen MH.
The antiplatelet activity of pmc, a potent a-tocopherol analogue, is mediated through inhibition of cyclo-oxygenase.
. Br. J. Pharmacol.
.1999
;(127):1206-1212
|
|
| 254. |
1999
Sheu JR, Hung WC, Su CH, Lin CH, Lee LW, Lee YM and Yen MH.
The antiplatelet activity of Escherichia coli lipopolysaccharide is mediated through a nitric oxide/cyclic GMP pathway.
. Eur J Haematol
.1999
;(62):317-326
|
|
| 255. |
1999
Lee LW, Peng HC, Ko WC, Hung WC, Su CH, Lin CH, Huang TF, Yen MH and Sheu JR.
Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation.
. Eur. J. Pharmacol.
.1999
;(364):239-246
|
|
| 256. |
1999
Hung WC, Lee CR, Chen YC, Sung MY, Yeh MH and Sheu RJ.
Effect of escherichia coli lipopolysaccharide on human platelets.
. NTJM
.1999
;(1):47-54
|
|
| 257. |
1999
Ko WC, Kuo SW, Sheu JR, Lin CH, Tzeng SH and Chen CM.
Relaxant action mechanisms of quercetin 3,3',4',5,7-pentamethy1 enter in isolated guinea pig trachea.
. NTJM
.1999
;(2):98-106
|
|
| 258. |
1999
Ko WC, Kuo SW, Sheu JR, Lin CH, Tzeng SH and Chen CM.
Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationshios.
. Planta Medica
.1999
;(65):273-275
|
|
| 259. |
1999
Lin CH, Sheu SY, Lee HM, Ho YS, Lee WS, Ko WC and Sheu JR.
Involvement of protein kinase C-g in IL-1b-induced cyclo-oxygenase-2 expression in human pulmonary epithelial cells.
. Mol. Pharmacol. (accepted).
.1999
|
|
| 260. |
1999
Sheu JR, Hung WC, Wu CH, Ma MC, Kan YC, Lin CH, Lin MS, Luk HN and Yen MH.
Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia.
. Circulation
.1999
;(22):3056-3062
|
|
| 261. |
1999
Sheu JR, Lee CR, Hsiao G, Hung WC, Lee YM, Chen YC and Yen MH.
Comparison of the relative activities of a-tocopherol and pmc on platelet aggregation and antioxidative activity.
. Life Sci.
.1999
;(65):197-206
|
|
| 262. |
1999
Lee YM, Peng YY, Sheu JR, Cheng CH, Yen MH..
The effect of a newly synthesized ATP-sensitive potassium channel opener, MJ-355, on blood pressure and myocardial ischemia-reperfusion injury in rats.
. Jpn. J. Pharmacol
.1999
;(81):185-193
|
|
| 263. |
1999
Sheu JR.
Pharmacological effects of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa.
. Cardiovasc. Drug Reviews
.1999
;(17):237-245
|
|
| 264. |
1998
Sheu JR, Kan YC, Hung WC, Su CH, Lin CH, Lee YM and Yen MH.
The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C.
. Thromb. Res.
.1998
;(92):53-64
|
|
| 265. |
1998
Sheu JR, Lee YM, Lee LW, Luk HN and Yen MH.
Inhibitory mechanisms of naloxone on human platelets.
. Clin. Exp. Pharmacol. Physiol.
.1998
;(25):585-591
|
|
| 266. |
1998
Ko WC, Sheu JR, Tzeng SH and Chen CM.
The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats.
. Planta Medica
.1998
;(64):195-290
|
|
| 267. |
1998
Chen MJ, Lee YM, Sheu JR, Hu CT and Yen MH.
ATP-sensitive potassium-channel-opening activity in the rat of CL-065, a 3-[(substituted-carbonyl)amino]-2H-1-benzopyran.
. J. Pharma. Pharmacol.
.1998
;(50):1-8
|
|
| 268. |
1998
Lin CH, Lee YM, Sheu JR, Cheng CY, Chang MJ and Yen MH.
Pharmacological characteristics of MJ-451, a new benzopyran-dreived ATP-sensitive potassium channel opener, in guinea-pig isolated tracts.
. Pharmacology
.1998
;(57):314-322
|
|
| 269. |
1998
Ko WC, Charng CY, Sheu JR, Tzeng SH and Chen CM.
Effect of butylidenephthalide on calcium mobilization in isolated rat aorta.
. J. Pharm. Pharmacol.
.1998
;(50):1365-1369
|
|
| 270. |
1997
Ko WC, Sheu JR, Leu YR, Tzeng SH and Chen CM.
Stereoselectivity of butylidenephthalide on voltage-dependent calcium channels in isolated guinea-pig ileum.
. J. Pharma. Pharmacol.
.1997
;(49):1121-1125
|
|
| 271. |
1997
Sheu JR, Hung WC, Lee LW, Chang PT, Kan YC and Mao HY.
Mechanism involved in the antiplatelet activity of naloxone in human platelets.
. Biochem. Biophys. Res. Commun.
.1997
;(231):12-16
|
|
| 272. |
1997
Sheu JR, Kan YC, Hung WC, Ko WC and Yen MH.
Mechanisms involved in the antiplatelet activity of tetramethylpyrazine in human platelets.
. Thromb. Res.
.1997
;(88):259-270
|
|
| 273. |
1997
Sheu JR, Ko WC, Hung WC, Peng HC and Huang TF.
Interaction of thrombin-activated platelets with extracellular matrices ( fibronectin and vitronectin): comparison of the activity of Arg-Gly-Asp-containing venom peptides and monoclonal antibodies against glycoprotein IIb/IIIa complex.
. J. Pharma. Pharmacol.
.1997
;(49):78-84
|
|
| 274. |
1997
Yen MH, Liu YC, Hong HJ, Sheu JR and Wu CC.
Role of nitric oxide in lipopolysaccharide-induced mortality from spontaneously hypertensive rats.
. Life Sci.
.1997
;(60):1223-1230
|
|
| 275. |
1997
Sheu JR, Yen MH, Hung WC, Lee YM, Su CH and Huang TF.
Triflavin inhibits platelet-induced vasocontraction in deendothelialized aorta. Arterioscl.
. Thromb. Vas. Biol.
.1997
;(17):3461-3468
|
|
| 276. |
1997
Sheu JR, Yen MH, Kan YC, Hung WC, Chang PT and Luk HN.
Inhibition of angiogenesis in vitro and in vivo: comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-avb3 integrin monoclonal antibody.
. Biochim. Biophys. Acta.
.1997
;(1336):445-454
|
|
| 277. |
1996
Sheu JR, Hung WC, Lee YM and Yen MH.
Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from evodia rutaecarpa. Eur.
. J. Pharmacol.
.1996
;(318):469-475
|
|
| 278. |
1996
Sheu JR, Lee YM, Peng IH and Yen MH.
Effect of DC-015, a novel potent and selective a1-adrenoceptor antagonist on plasma lipid and vascular reactivity in hyperlipidemic rats. Clin. Exp. Pharmacol.
. Physiol.
.1996
;(23):207-213
|
|
| 279. |
1996
Sheu JR, Lin CH, Peng HC and Huang TF.
Triflavin, an Arg-Gly-Asp-containing peptide, inhibits the adhesion of tumor cells to matrix proteins via binding to multiple integrin receptors expressed on human hepatoma cells.
. Proc. Soc. Exp. Biol. Med.
.1996
;(213):71-79
|
|
| 280. |
1996
Yen MH, Sheu JR, Peng IH and Chern JW.
Pharmacological activity of DC-015, a novel potent and selective a1-adrenoceptor antagonist.
. J. Pharm. Pharmacol.
.1996
;(48):90-95
|
|
| 281. |
1996
Peng IH, Sheu JR, Lee YM and Yen MH.
Antihypertensive and hypolipidemic effects of DC-015, a novel potent and selective a1-adrenoceptor antagonist comparison with prazosin in spontaneously hypertensive rats.
. J. Biomed. Sci.
.1996
;(3):108-116
|
|
| 282. |
1996
Sheu JR and Huang TF.
Triflavin, an arg-gly-asp-containing peptide, inhibits B16-F10 mouse melanoma cell adhesion to matrix proteins via direct binding to tumor cells.
. J. Biomed. Sci.
.1996
;(3):359-364
|
|