侯文琪(Hou, Wen-Chi)　教授

Email
wchou@tmu.edu.tw
現   職
生藥學研究所 教授

學經歷

學　歷

畢業學校與學位[修業時間]
國立臺灣大學農業化學研究所 博士
1989/09/01~1994/06/01
國立臺灣大學農業化學系 學士
1985/09/01~1989/06/01

本校學術經歷

任職單位與職稱[起迄時間]
生藥學研究所教授
2007/02/01~
生藥學研究所副教授
2006/08/01~2007/01/31
生物資源技術學系副教授
2003/02/01~2006/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
研究發展處副研發長
2016/08/01 ~ 2018/12/04
未聘任老師虛擬單位副研發長
2016/08/01 ~ 2017/09/20
非正式組織虛擬單位副研發長
2016/08/01 ~ 2017/09/20
中草藥臨床藥物研發博士學位學程
2013/08/01 ~
生藥學研究所所長
2010/08/01 ~ 2013/07/31
研發處企劃組組長
2006/08/01 ~ 2006/11/19
研究管理組組長
2003/09/15 ~ 2006/11/19

其它經歷

任職單位與職稱[起迄時間]
中央研究院一般博士後研究學者
1999/01/01~2000/07/31
中央研究院博士級臨時助理
1998/08/01~1998/12/31
中央研究院博士後研究員
1996/07/01~1998/07/31

專長與研究領域

學門領域
蛋白質、酵素純化與蛋白質機能性研究
食品及農化
學術專長
電泳、western blotting、蛋白質純化

論文著作

清冊下載

論文 Journal Paper


1. 2024 Hsieh YY ,Hou WC,Hsu SJ,Liaw CC,Huang C,Shih MCM, Shen YC, Chen YF, Lee CK, Lee OK, Wu CC, Lee IJ, Cheng JJ, Hou YC, Liu HK. Consumption of carotenoid-rich Momordica cochinchinensis (Gac) aril improves glycemic control in type 2 diabetic mice partially through taste receptor type 1 mediated glucagon-like peptide 1 secretion . Food & Function (accepted) .2024

2. 2024 Yang CH,Li CW,Sie YY,Chen LC,Yuan YH,Hou WC. Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice . Botanical Studies .2024

3. 2024 Wang TJ ,Hou WC,Hsiao BY,Lo TH,Chen YT,Yang CH, Shih YT, Liu JC. 2-Hydroxyl hispolon reverses high glucose induced endothelial progenitor cell dysfunction through the PI3K/AKT/eNOS and AMPK/HO-1 pathways . British Journal of Pharmacology .2024

4. 2023 Liu YH ,Lin YS,Sie YY,Wang CC,Chang CI,Hou WC. Vitisin B, a resveratrol tetramer from Vitis thunbergii var. taiwaniana, ameliorates impaired glucose regulations in nicotinamide/ streptozotocin-induced type 2 diabetic mice . Journal of Traditional and Complementary Medicine .2023 ;(13):479-488

5. 2023 Sie YY,Chen LC,Li CJ,Yuan YH,Hsiao SH,「Lee MH, Wang CC, Hou WC」. Inhibition of acetylcholinesterase and amyloid-β aggregation by piceatannol and analogs: assessing in vitro and in vivo impact on a murine model of scopolamine-induced memory impairment . Antioxidants .2023 ;(12):---

6. 2023 Sie YY ,Chen LC,Li CW,Wang CC,Li CJ,Liu DZ,「Lee MH, Chen LG, Hou WC」. Extracts and scirpusin B from recycled seeds and rinds of passion fruits (Passiflora edulis var. Tainung No. 1) exhibit improved functions in scopolamine-induced impaired-memory ICR mice . Antioxidants .2023 ;(12):---

7. 2022 Chen LG,Wang CC,Lee YS,Sie YY,Chang CI,Hou WC. Vitisin A, a resveratrol tetramer, improves scopolamine-induced impaired learning and memory functions in amnesiac ICR mice . Biomedicines .2022

8. 2022 Liu YH,Lu YL,Chang YC,Chyuan JH,Lee TH,Hou WC. Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro . J. Sci. Food Agric. .2022 ;(102):6771-6779

9. 2021 Chen LG,Lin SY,Lee YS,Wang CC,Hou WC. Hydrolysable tannins exhibit acetylcholinesterase inhibitory and anti-glycation activities in vitro and learning and memory function improvements in scopolamine-induced amnesiac mice. . Biomedicines .2021 ;(9):---

10. 2020 Lin CM ,Lin YT,Lee TL,Imtiyaz Z,Hou WC*,Lee MH* . In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland . J. Food Drug Anal. .2020 ;(28):147-158

11. 2020 Liu YH,Lee CJ,Chen LC,Lee TL,Hsieh YY,[Han CH], [Yang CH], [Huang WJ], and [Hou WC]. Acetylcholinesterase inhibitory activity and neuroprotection in vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice . Food & Function .2020 ;(11):2328-2338

12. 2020 Lu YL,Lee CJ,Lin SY,Hou WC. Reductions of copper ion-mediated low-density lipoprotein (LDL) oxidations of trypsin inhibitors, the sweet potato root major proteins, and LDL binding capacities. . Bot Stud .2020 ;(61):---

13. 2019 Liu YH,Lee TL,Han CH,Lee YS,Hou WC. Anti-glycation, anti-hemolysis, and ORAC activities of demethylcurcumin and tetrahydroxycurcumin in vitro and reductions of oxidative stress in D-galactose-induced BALB/c mice in vivo . Botanical Studies .2019 ;(60)

14. 2018 Wu GC, Lin SY,Liang HJ,Hou WC. 135-day interventions of yam dioscorin and the dipeptide Asn-Trp (NW) to reduce weight gains and improve impaired glucose tolerances in high-fat diet-induced C57BL/6 mice . J Agric Food Chem. .2018 ;(66):645-652

15. 2017 Lu YL,Lin SY,Fang SU,Hsieh YY,Chen CR,Wen CL, Chang CI, Hou WC. Hot-water extracts from roots of Vitis thunbergii var. taiwaniana and identified ε-viniferin improve obesity in high-fat diet-induced mice . J. Agric. Food Chem. .2017 ;(65):2521-2529

16. 2017 Liu YH,Lu YL,Liu DZ,Hou WC. Anti-glycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro . Drug Design, Development and Therapy .2017 ;(11):2139-2147

17. 2016 Liu YH,Lin YS,Huang YW,Fang SU,Lin SY,Hou WC. Protective effects of minor components of curcuminoids on hydrogen peroxide-treated human HaCaT keratinocytes . J. Agric. Food Chem. .2016 ;(64):3598-3608

18. 2016 Chen PT,Chen ZT,Hou WC,Yu LC,Chen RPY. Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease . Scientific Reports .2016 ;(6):29760

19. 2016 Lin YS,Han CH,Lin SY,Hou WC. Synthesized peptides from yam dioscorin hydrolysis in silico exhibit dipeptidyl peptidase-IV inhibitory activities and oral glucose tolerance improvements in normal mice . J. Agric. Food Chem .2016 ;(64):6451-6458

20. 2015 Lin YS,Wu WC,Lin SY,Hou WC. Glycine hydroxamate inhibits tyrosinase activity and melanin contents through downregulating cAMP/PKA signaling pathways. . Amino Acids .2015 ;(47):617-625

21. 2015 Shih SL,lin YS,Lin SY,Hou WC. Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats . Botanical Studies .2015 ;(56):4-X

22. 2015 Liu YH,Lin YS,Lin KL,Lu YL,Chen CH,Chien MY, Shang HF, Lin SY, Hou WC. Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo . Bot. Stud. .2015 ;(56):17-X

23. 2015 Lin YS,Chen CR,Wu WH,Wen CL,Chang CI,Hou WC. Anti-α-glucosidase and anti-dipeptidyl peptidase-IV activities of extracts and purified compounds from Vitis thunbergii var. taiwaniana . J. Agric. Food Chem. .2015 ;(63):6393-6401

24. 2015 Lin SY,Huang GC,Hsieh YY,Lin YS,Han CH,Wen CL, Chang CI, Hou WC. Vitis thunbergii var. taiwaniana extracts and purified compounds ameliorate obesity in high-fat diet-induced obese mice. . J. Agric. Food Chem. .2015 ;(63):9286-9294

25. 2014 Han CH,Lin YS,Lin SY,Hou WC. Antioxidant and antiglycation activities of the synthesised dipeptide, Asn-Trp, derived from computer-aided simulation of yam dioscorin hydrolysis and its analogue, Gln-Trp. . Food Chemistry .2014 ;(147):195-202

26. 2014 Han CH,Lin YF,Lin YS,Lee TL,Huang WJ,Lin SY, Hou WC. Effects of yam tuber protein, dioscorin, on attenuating oxidative status and learning dysfunction in D-galactose-induced BALB/c mice . Food and Chemical Toxicology .2014 ;(65):356-363

27. 2014 Lin YS,Lu YL,Wang GJ,Liang HJ,Hou WC. Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin . Bot. Stud. .2014 ;(55):49-X

28. 2014 Han CH,Lin YS,Lee TL,Liang HJ,Hou WC. Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in D-galactose-induced BALB/c mice . Food & Function .2014 ;(5):2228-2236

29. 2013 Huang GJ,Deng JS,Huang SS,Lee CY,Hou WC,Wang SY, Sung PJ, Kuo YH. Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. . Food Chem .2013 ;(141):3020-3027

30. 2013 Chiu CS,Deng JS,Chang HY,Chen YC,Lee MM,Hou WC, Lee CY, Huang SS, Huang GJ.. Antioxidant and anti-inflammatory properties of Taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds. . Food Chem .2013 ;(141):1087-1096

31. 2013 Han CH,Liu JC,Fang SU,Hou WC. Antioxidant activities of the synthesized thiol-contained peptides derived from computer-aided pepsin hydrolysis of yam tuber storage protein, dioscorin . Food Chemistry .2013 ;(138):923-930

32. 2013 Liu YH,Lu YL,Han CH,Hou WC. Inhibitory activities of acteoside, isoacteoside, and its structural constituents against proteinglycation in vitro . Botanical Studies .2013 ;(54):6-X

33. 2013 Huang SS,Chiu CS,Lin TH,Lee MM,Lee CY,Chang SJ, Hou WC, Huang GJ, Deng JS.. Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima. . J Ethnopharmacol .2013 ;(147):395-405

34. 2013 Deng JS,Huang SS,Lin TH,Lee MM,Kuo CC,Sung PJ, Hou WC, Huang GJ, Kuo YH.. Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice. . J. Agric. Food Chem. .2013 ;(61):5064-5071

35. 2012 Lin YS,Chen SH,Huang WJ,Chen CH,Chien MY,Li SY, Hou WC. Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities . Food Chemistry .2012 ;(132):2074-2080

36. 2012 Lu YL,Chia CY,Liu YW,Hou WC. Biological activities and applications of dioscorins, the major tuber storage proteins of yam. . J. Tradit. Complement. Med. .2012 ;(1):41-46

37. 2012 Lu YL,Liu YH,Chyuan JH,Cheng KT,Liang WL,Hou WC. Antioxidant activities of different wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) cultivars . Bot. Stud. .2012 ;(53):207-214

38. 2012 Lin YS,Chuang MT,Chen CH,Chien MY,Hou WC. Nicotinic acid hydroxamate down-regulated the melanin synthesis and tyrosinase activity through activating the MEK/ERK and AKT/GSK3ß signaling pathways . J. Agric. Food Chem. .2012 ;(60):4859-4864

39. 2012 Liu YH,Lin YS,Lee TL,Hou WC. Semicarbazide-sensitive amine oxidase inhibitory and hydroxyl radical scavenging activities of aspartic acid β-hydroxamate and glutamic acid γ-monohydroxamate. . Bot. Stud. .2012 ;(53):301-306

40. 2012 Chen CH,Lin YS,Chien MY,Hou WC,Hu ML. Antioxidant and antihypertensive activities of acteoside and its analogs . Bot. Stud. .2012 ;(53):421-429

41. 2012 Lin YS,Lu YL,Wang GJ,Chen LG,Wen CL,Hou WC. Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities. . J. Agric. Food Chem. .2012 ;(60):7435-7441

42. 2011 Shih CK,Ho CJ,Li SC,Yang SH,Hou WC,Cheng HH. Preventive effects of rice bran oil on 1,2-dimethylhydrazine/dextran sodium sulphate-induced colon carcinogenesis in rats . Food Chemistry .2011 ;(126):562-567

43. 2011 Huang MH,Huang SS,Wang BS,Wu CH,Sheu MJ,Hou WC, Lin SS, Huang GJ. Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo . J. Ethnopharmacol .2011 ;(133):743-750

44. 2011 Liu YH,Huang WJ,Lu YL,Lee CC,Tasi YF,Wu WC, Hou WC. Semicarbazide-sensitive amine oxidase inhibitory activity of galacturonic acid hydroxamate . Bot. Studies .2011 ;(52):35-40

45. 2011 Liu YH,Liang WL,Lee CC,Tsai YF,Hou WC. Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of glucuronic acid hydroxamate . Food Chemistry .2011 ;(129):423-428

46. 2011 Han CH,Liu JC,Chen KH,Lin YS,Chen CT,Fan CT, Lee HL, Liu DZ, Hou WC. Antihypertensive activities of processed garlic on spontaneously hypertensive rats and hypertensive humans. . Bot Studies .2011 ;(52):277-283

47. 2011 Lu YL,Liu YH,Liang WL,Chuang JH,Cheng KT,Liang HJ, Hou WC. Antibacterial and cytotoxic activities of different wild bitter gourd cultivars (Momordica charantia L. var. abbreviata Seringe) . Botanical Studies .2011 ;(52):427-434

48. 2010 Liu YH,Wu WC,Lu YL,Lai YJ,Hou WC. Antioxidant and amine oxidase inhibitory activities of hydroxyurea . Biosci. Biotechnol. Biochem .2010 ;(74):1256-1260

49. 2010 Wang CK,Chen LG,Wen CL,Hou WC,Hung LF,Yen SJ, Shen YJ, Lin SY, Liang YC. Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo . J. Med. Food .2010 ;(13):170-178

50. 2010 Huang GJ,Huang SS,Lin SS,Shao YY,Chen CC,Hou WC, Kuo YH. Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice . J. Agric. Food Chem .2010 ;(58):7445-7452

51. 2010 Huang CY,Wen CL,Lu YL,Lin YS,Chen LG,Hou WC. Antihypertensive activities of extracts from tissue cultures of Vitis thunbergii var. taiwaniana . Bot. Studies .2010 ;(51):317-324

52. 2010 Huang GH,Yang CM,Chang YS,Amagaya S,Wang HC,Hou WC, Huang SS, Hu ML. Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways . J. Agric. Food Chem. .2010 ;(58):9468-9475

53. 2010 Huang GJ,Chiu CS,Wu CH,Huang SS,Amegaya S,Hou WC, Sheu MJ, Liao JC, and Lin YH. Redox status of Bowman-Birk inhibitor from soybean influence its in vitro antioxidant activities . Bot. Studies .2010 ;(51):431-437

54. 2009 Liu DZ,Liang HJ,Han CH,Lin SY,Chen CT,「Fan M, Hou WC」. Feeding trial of instant food containing lyophilized yam powder in hypertensive subjects. . J. Sci Food Agric. .2009 ;(89):138-143

55. 2009 Udenigwe, C. C.,Lu, Y. L.,Han, C. H.,Hou, W. C.,Aluko, R. E.. Flaxseed protein-derived peptide fractions: Antioxidant properties and inhibition of lipopolysaccharide-induced nitric oxide production in murine macrophages. . Food Chem. .2009 ;(116):277-284

56. 2009 Liu, Y. H.,Lin, Y. S,Liu, D. Z.,Han, C. H.,Chen, C. T.,Fan, M., and Hou, W. C.. Effects of different types of yam (Dioscorea alata) products on the blood pressure of spontaneously hypertensive rats. . Biosci. Biotechnol. Biochem., .2009 ;(73):1371-1376

57. 2009 Liu YW,Liu JC,Huang CY,Wang CK,Shang HF,Hou WC. Effects of oral administration of yam tuber storage protein, dioscorin, to BALB/c Mice for 21-Days on immune responses . J. Agric. Food Chem. .2009 ;(57):9274-9279

58. 2008 Liu YH,Lin SY,Lee CC,Hou WC. Antioxidant and nitric oxide production inhibitory activities of galacturonyl hydroxamic acid . Food Chemistry .2008 ;(109):159-166

59. 2008 Lin SY,Wang CC,Lu YL,Wu WC,Hou WC. Antioxidant, anti-semicarbazide-sensitive amine oxidase, and antihypertensive activities of geraniin isolated from Phyllanthus urinaria . Food Chem Toxicology .2008 ;(46):2485-2492

60. 2008 Liu DZ,Liang HJ,Han CH,Lin SY,Chen CT,Fan M and Hou WC. Feeding trial of instant food containing lyophilized yam powder in hypertensive subjects . J. Sci Food Agric. (accepted) .2008

61. 2008 Lin CW,Hou WC,Shen SC,Juan SH,Ko CH,Wang LM, {Chen YC}. Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells . Carcinogenesis .2008 ;(29):1807-1815

62. 2008 Lin CW,Shen SC,Hou WC,Yang LY,Chen YC. Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9 . Mol Cancer Ther .2008 ;(7):1195-1206

63. 2007 Liu YH,Chuang MT,Hou WC. Methanol-soluble, β-eliminat ion products from preparations of alginic acid hydroxamate exhibited DPPH scavenging and angiotensin converting enzyme inhibitory activities . Botanical Studies .2007 ;(48):141-146

64. 2007 Liu DZ,Wu WC,Liang HJ,Hou WC. Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of alginic acid hydroxamates . J. Sci. Food Agric. .2007 ;(87):138-146

65. 2007 Liu DZ,Liang YC,Lin SY,Lin YS,Wu WC,[Hou WC, Su CH]. Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-Chih) in spontaneously hypertensive rats . Biosci. Biotechnol. Biochem. .2007 ;(71):23-30

66. 2007 Shang HF,Cheng HC,Liang HJ,Liu HY,Liu SY,Hou WC. Immunostimulatory activities of yam tuber mucilages . Bot. Studies .2007 ;(48):63-70

67. 2007 Shih CK,Chen SH,Hou WC,Cheng HH. A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats . Food Res. International .2007 ;(40):842-847

68. 2007 Hou WC,Tsay HS,Liang HJ,Lee TY,Wang GJ,Liu DZ. Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge . J. Ethnopharmacol. .2007 ;(111):483-489

69. 2007 Wang GJ,Lin SY,Wu WC,Hou WC. DPPH radical scavenging, semicarbazide-sensitive amine oxidase inhibitory and cytotoxic activities of Taiwanofungus camphoratus (Chang-Chih) . Biosci. Biotechnol. Biochem. .2007 ;(71):1873-1878

70. 2007 Chuang MT,Lin YS,Hou WC. Ancordin, the major rhizome protein of madeira-vine, with trypsin inhibitory and stimulatory activities in nitric oxide productions . Peptides .2007 ;(28):1311-1316

71. 2007 Liu YW,Shang HF,Wang CK,Hsu FL,Hou WC. Immunomodulatory activity of dioscorin, the storage protein of yam (Dioscorea alata cv. Tainong No.1) tuber . Food Chem. Toxicol. .2007 ;(45):2312-2318

72. 2006 Fu SL,Hsu YH,Lee PY,Hou WC,Hung LC,Lin CH, Chen CM, Huang YJ. dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages . Biochem. Biophys. Res. Communi. .2006 ;(339):137-144

73. 2006 Lee TH,Liu DZ,Hsu FL,Wu WC,Hou WC. Structure-activity relationships of five myricetin galloglycosides from leaves of Acacia confusa . Botanical Studies .2006 ;(47):37-43

74. 2006 Liu YH,Liang HJ,Cheng HC,Liu YW,Hou WC. Comparisons of in vitro antioxidant activities of storage proteins in tuber of two Dioscorea species . Botanical Studies .2006 ;(47):231-237

75. 2006 Wu TH,Liao JH,Hou WC,Huang FY,Maher TJ,Hu CC. Astaxanthin protects against oxidative stress and calcium-induced procine lenes protein degradation . J. Agric. Food Chem .2006 ;(54):2418-2423

76. 2006 Huang DJ,Chen HJ,Hou WC,Lin CD,Lin YH. Sweet potato (Ipomoea batatas L. Lam Tainong 57) storage root mucilage with antioxidant activities in vitro . Food Chem .2006 ;(98):774-781

77. 2006 Chen HJ,Huang DJ,Hou WC,Liu JS,Lin YH. Molecular cloning and characterization of a granulin-containing cysteine protease SPCP3 from sweet potato (Ipomoea batatas) senescent leaves. . J. Plant Physiol. .2006 ;(163):863-876

78. 2006 Wang CC,Lin SY,Cheng HC,Hou WC. Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells. . Food Chem Toxicol. .2006 ;(44):1308-1345

79. 2006 Liu DZ,Wu WC,Liang HJ,Hou WC. Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of alginic acid hydroxamates . J. Sci. Food Agric. (accepted) .2006

80. 2006 Liu DZ,Liang YC,Lin SY,Lin YS,Wu WC,Hou WC, Su CH. Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-Chih) in spontaneously hypertensive rats . Biosci. Biotechnol. Biochem.(accepted) .2006

81. 2006 Yang SS,Hou WC,Huang LW,Lee TH. A new r-lactone from leaves of Cinnamomum kotoense . Natural Product Research .2006 ;(20):1246-1250

82. 2006 Lin CL,LIn SY,Lin YH,Hou WC. Effects of tuber storage protein of yam (Dioscorea alata cv. Tainong No.1) and its peptic hydrolysates on spontaneously hypertensive rats. . J. Sci. Food Agric. .2006 ;(86):1489-1494

83. 2005 Hou WC,Han CH,Chen HJ,Wen CL,Lin YH. Storage proteins of two cultivars of sweet potato (Ipomoea batatas L.) and their protease hydrolysates exhibited antioxidant activity in vitro . Plant Science .2005 ;(168):449-456

84. 2005 Hou WC,Lin RD,Chen CT,Lee MH. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla . J. Ethnopharmacology .2005 ;(100):216-220

85. 2005 Huang DJ,Chen HJ,Hou WC,Chen TE,Hsu WY,Lin YH. Expression and function of cysteine proteinase cDNA from sweet potato (Ipomoea batatas L. Lam Tainong 57) storage roots . Plant Science .2005 ;(169):423-431

86. 2005 Lin SY,Liu HY,Lu YL,Hou WC. Antioxidant activities of mucilages from different Taiwanese yam cultivars . Bot. Bull. Acad. Sin. .2005 ;(46):183-188

87. 2005 Liu DZ,Lu YL,Cheng HC,Hou WC. Immobilized zinc affinity chromatography of pectin hydroxamic acids for purification of trypsin inhibitors from soybean and sweet potato . J. Agric. Food Chem. (in press) .2005

88. 2005 Lin CL,Lin SY,Lin YH,Hou WC. Effects of tuber storage protein of yam (Dioscorea alata cv. Tainong No.1) and its peptic hydrolysates on spontaneously hypertensive rats . J. Sci. Food Agric. (in press) .2005

89. 2005 Hou WC,Lin RD,Lee TH,Huanh YH,Hsu FL,Lee MH. The phenolic constitutes and free radical scavenging activities of Gynura formosana Kiamnra . J. Sci Food Agric. .2005 ;(85):615-621

90. 2004 Hou WC,Chen HJ,Han CH,Lin CY,Lin YH. Glutathione peroxidase-like activity of 33 kDa trypsin inhibitor from roots of sweet potato (Ipomoea batatas L. Lam Tainong 57) . Plant Science .2004 ;(166):1541-1546

91. 2004 Chen HJ,Hou WC,Liu JS,Yang CY,Huang DJ,Lin YH. Molecular cloning and characterization of a cDNA encoding asparaginyl endopeptidase from sweet potato (Ipomoea batatas L. Lam) senescent leaves . J. Experimental Botany .2004 ;(55):825-835

92. 2004 Liu DZ,Lin YS,Hou WC. Monohydroxamates of aspartic acid and glutamic acid exhibited antioxidant and angiotensin converting enzyme inhibitory activities . J. Agric. Food Chem. .2004 ;(52):2386-2390

93. 2004 Cheng HH,Lai MH,Hou WC,Huang CL. Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects . J. Agric. Food Chem. .2004 ;(52):1385-1389

94. 2004 Huang DJ,Chen HJ,Hou WC,Lin YH. Isolation and characterization of thioredoxin h cDNA from sweet potato (Ipomoea batatas L. Lam Tainong 57) storage roots . Plant Science .2004 ;(166):515-523

95. 2004 Huang DJ,Chen HJ,Hou WC,Chen TE,Lin YH. In vitro reduction of trypsin inhibitor by purified NADPH/thioredoxin system from sprouts of sweet potato (Ipomoea batatas L. Lam) storage roots . Plant Science .2004 ;(166):435-441

96. 2004 Yang SS,Cheng KT,Lin YS,Liu YW,Hou WC. Pectin hydroxamic acids exhibited antioxidant activities in vitro . J. Agric. Food Chem. .2004 ;(52):4270-4273

97. 2004 Hou WC,Liang HJ,Wang CC,Liu DZ. Detection of glutathione reductase after electrophoresis on either native or sodium dodecylsulfate polyacrylamide gels . Electrophoresis .2004 ;(25):2926-2931

98. 2004 Huang DJ,Chen HJ,Hou WC,Lin CD,Lin YH. Active recombinant thioredoxin h protein with antioxidant activities from sweet potato (Ipomoea batatas L. Lam Tainong 57) storage roots . J. Agric. Food Chem. .2004 ;(52):4720-4724

99. 2004 Hou WC,Wu WC,Yang CY,Chen HJ,Liu SY,Lin YH. Antioxidant activities of methanolic and hot-water extracts from leaves of three cultivars of Mai-Men-Dong (Liriope spicata L.) . Bot. Bull. Acad. Sin. .2004 ;(45):285-290

100. 2003 Hou WC., Lin RD, Cheng KT, Hung YT, Cho CH, Chen CH, Hwang SY, Lee MH.. Free radical-scavenging activity of Taiwanese native Plants. . Phytomedicine .2003 ;(10)

101. 2003 Hou WC, Lu YL, Liu SY, Lin YH. Activities of superoxide dismutase and glutathione peroxidase in leaves of different cultivars of Liriope spicata L. on 10% SDS-PAGE gels . Bot. Bull. Acad. Sin. .2003 ;(44):37-41

102. 2003 Chen HJ, Hou WC, Yang CY, Huang DJ, Liu JS, and Lin YH. Molecular cloning of two metallothionein-like protein genes with differential expression patterns from sweet potato (Ipomoea batatas (L.) Lam.) leaves . J. Plant Physiol. .2003 ;(160):547-555

103. 2003 Hou WC, Chen HJ, and Lin YH. Antioxidant peptides with angiotensin converting enzyme inhibitory activities and applications for angiotensin converting enzyme purification . J. Agric. Food Chem. .2003 ;(51):1706-1709

104. 2003 Liang WL, Huang HM, Lin RD, and Hou WC. Screening of natural inhibitors of penicillinase by copolymerization of hydrolyzed starch or glycogen in sodium dodecylsulfate polyacrylamide gels for detecting penicillinase activity . Bot. Bull. Acad. Sin.(accepted) .2003

105. 2003 Lin RD, Hou WC, Yen KY, Lee MH. Inhibition of Monoamine Oxidase B (MAO-B) by Chinese Herbal Medicines. . Phytomedicine. .2003 ;(11)

106. 2003 Liu YW, Han CH, Lee MH, Hsu FL, and Hou WC. Patatin, the tuber storage protein of potato (Solanum tuberosum L.), exhibited antioxidant activity in vitro . J. Agric. Food Chem.(accepted) .2003

107. 2003 Hou WC, Lee MH, Hsu FL, Lin YH. Inhibitory activities of semicarbazide-sensitive amine oxidase and angiotensin converting enzyme of pectin hydroxamic acid . J. Agric. Food Chem. .2003 ;(51):6362-6366

108. 2003 Lee MH, Lin YH, Lin YH, Hsu FL, Hou WC. The mucilage of yam (Dioscorea batatas Decne) tuber exhibited angiotensin converting enzyme inhibitory activities . Bot. Bull. Acad. Sin. .2003 ;(44):267-273

109. 2002 Lin, C. L., Chen, H. J. and Hou, W. C.. Activity staining of glutathione peroxidase after electrophoresis on either native or sodium dodecylsulfate polyacrylamide gels . Electrophoresis .2002 ;(23):513-516

110. 2002 Lee, W.R., Shen, S.C., Lin, H.Y., Hou, W.C., Yang, L.L., Chen, Y.C.. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca2+-dependent endonuclease . Biochemical Pharmacology .2002 ;(63):225-236

111. 2002 Chen, H.J., Hou, W.C., Kuc, J., Lin, Y.H.. Salicylic acid mediates alternative signal transduction pathway for pathogenesis-related acidic 1,3-glucanase (protein N) induction in tobacco cell suspension culture . Journal of Plant Physiology .2002 ;(159):331-337

112. 2002 Lee, M. H., Chuang, M. T. and Hou, W. C.*. Activity staining of plasma amine oxidase after polyacrylamide gel electrophoresis and its application for natural inhibitor screenings . Electrophoresis .2002 ;(23):2369-2372

113. 2002 Hou, W. C. and Lin, Y. H. Sweet potato (Ipomoea batatas (L.) Lam) trypsininhibitors, the major root storage proteins, inhibit one endogenous serine protease activity. . Plant Science .2002 ;(163):733-739

114. 2002 Hou, W. C. Huang, D. J. and Lin, Y. H.. Aspartic type protease degrade trypsin inhibitors,the major root storage proteins of sweet potato (Ipomoea batatas (L.) Lam cv.Tainong 57). . Bot. Bull. Acad. Sin. .2002 ;(43):271-276

115. 2002 Hsu, F. L., Lin, Y. H., Lee, M. H., Lin, C. L., and Hou, W. C.. Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No.1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitoryactivities. . J. Agric. Food Chem., .2002 ;(50):6109-6113

116. 2002 Hou WC, Hsu FL, Lee MH. Yam (Dioscorea batatas Decne) Tuber Mucilage Exhibited Antioxidant Activities In Vitro . Planta Medica .2002 ;(68):1072-1076

117. 2002 Hsing-Hsien Cheng, Wen-Chi Hou, and Mei-Ling Lu. Interactions of lipid metabolism and intestinal physiology with Tremella fuciformis Berk edible mushroom in rats fed a high cholesterol diet with or without Nebacitin . J. Agric. Food Chem. .2002 ;(50):7438-7443

118. 2001 Hou, WC., Chen, H. J., Lin, Y. H., Chen, Y. C., Yang, L. L., Lee, M. H.. Activity staining of isocitrate lyase after electrophoresis on either native or sodium dodecylsulfate polyacrylamide gels . Electrophoresis .2001 ;(22):2653-2655

119. 2001 Hou, W. C., Lee, M. H., Chen, H. J., Liang, W. L., Han, C. H., Liu, Y. W., Lin, Y. H.. Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber . J. Agric. Food Chem., .2001 ;(49):4956-4960

120. 2001 Lee, M. H., Lin, R. D., Shen, L. Y., Yang, L. L., Yen, K. Y. and Hou, W. C.. Monoamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don . J. Agric. Food Chem., .2001 ;(49):5551-5555

121. 2001 Chen, H. J., Hou, W. C., Kuc, J., Lin, Y. H.. Salicylic acid mediates alternative signal transduction pathways for pathogenesis-related acidic 1,3-glucanas (protein N) induction in tobacco cell suspension culturee . Journal of Plant Physiology (accepted, Dec. 13, 2001) .2001

122. 2001 Chen, H. J., Hou, W. C., Kuc, J., and Lin, Y. H.. Ca2+ -dependent and Ca2+ -independent excretion modes of salicylic acid in tobacco cell suspension culture . J. Experimental Botany (accepted, Feb. 15, 2001; publish at June issue) .2001

123. 2001 Chen, Y. C., Shen, S. C., Lee, W. R., Hou, W. C., Yang, L. L., and Tony, J. F.. Inhibition of NOS inhibitors and lipopolysaccharide induced inducible nitric oxide synthase and cyclooxygenase 2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages . J. Cellular Biochem., (accepted, Mar. 23, 2001) .2001

124. 2001 Hou, W. C., Chen, Y. C., Chen, H. J., Lin, Y. H., Yang, L. L., Lee, M. H.. Antioxidant activities of trypsin inhibitor, a 33 kDa root storage protein of sweet potato (Ipomoea batatas L. Lam cv. Tainong 57) . J. Agric. Food Chem.(accepted) JF0100705 .2001

125. 2000 Hou, W. C., Wang, Y. T., Lin, Y. H., Shiao, L. J., Chen, T. E., Wang, C. W. and Dai, H.. A complex containing both trypsin inhibitor and dehydroascorbate reductase activities isolated from mitochondria of etiolated mungbean seedlings . J. Exp. Bot. .2000 ;(51):345-351

126. 2000 Hou, W. C., Chen, H. J. and Lin, Y. H.. Dioscorins from different Dioscorea species all exhibit both carbonic anhydrase and trypsin inhibitor activities . Bot. Bull. Acad. Sin. .2000 ;(41):191-196

127. 2000 Chen, H. J., Hou, W. C. and Lin, Y. H.. Isolation and characterization of an isocitrate lyase gene from senescent leaves of sweet potato (Ipomoea batatas cv. Tainong 57) . J. Plant Physiol. .2000 ;(157):669-676

128. 1999 Hou, W. C., Chen. H. J., Chang. C. F. and Lin, Y. H.. Purification and properties of fatty acid esterases from yam (Dioscorea batatas Decne) tuber . Bot. Bull. Acad. Sin. .1999 ;(40):305-310

129. 1999 Hou, W. C., Chen, H. J. and Lin, Y. H.. Dioscorins, the major tuber storage proteins of yam (Dioscorea batatas Decne), with dehydroascorbate reductase and monodehydroascorbate reductase activities. . Plant Sci. .1999 ;(149):151-156

130. 1999 Hou, W. C., Chen, H. J., Chen, T. E. and Lin, Y. H.. Detection of protease activities using specific aminoacyl or peptidyl p-nitroanilide after sodium dodecylsulfate polyacrylamide gel elecrophoresis and their applications. . Electrophoresis .1999 ;(20):486-490

131. 1999 Hou, W. C., Chang, W. H. and Jiang, C. M.. Qualitative distinction of carboxyl groups distributions in pectins with ruthenium red. . Bot. Bull. Acad. Sin., .1999 ;(40):115-119

132. 1999 Hou, W. C., Liu, J. S., Chen H. J., Chen, T. E., Chang, C. F. and Lin, Y. H.. Dioscorin, the major tuber storage protein of yam (Dioscorea batatas Decne) with carbonic anhydrase and trypsin inhibitor activities. . J. Agric. Food Chem., .1999 ;(47):2168-2172

133. 1998 Hou, W. C. and Lin, Y. H.. Activity staining on polyacrylamide gels of trypsin inhibitors from leaves of sweet potato varieties . Electrophoresis .1998 ;(19):212-214

134. 1998 江啟銘, 侯文琪, 張為憲. 快速果膠酯脢膠體活性染色之研究 . 食品科學 .1998 ;(25):46-58

135. 1998 林耀輝 侯文琪 劉繼修. 甘藷儲藏性蛋白質---胰蛋白脢抑制因子 . Life Sciences Newsletter, NSC .1998 ;(12):7-12

136. 1998 Hou, W. C. and Lin, Y. H.. Activity staining of pectinesterase on polyacrylamide gels after acidic or sodium dodecylsulfate electrophoresis . Electrophoresis .1998 ;(19):692-694

137. 1998 Hou, W. C., Chen, Y. C. and Lin, Y. H.. Chitinase activity of sweet potato (Ipomoea batatas [L.] Lam var. Tainong 57) . Bot. Bull. Acad. Sin. .1998 ;(39):93-97

138. 1997 Hou, W. C. and Lin, Y. H.. Polyamine-bound trypsin inhibitors in sweet potato storage roots, sprouted roots and sprouts . Plant Science .1997 ;(126):11-19

139. 1997 Hou, W. C. and Lin, Y. H.. Dehydroascorbate reductase and monodehydroascorbate reductase activities of trypsin inhibitors, the major sweet potato (Ipomoea batatas [L.] Lam) root storage protein . Plant Sci. .1997 ;(128):151-158

140. 1997 Hou, W. C. and Lin, Y. H.. Egg white lysozyme purification with sweet potato leaf preparations. . J. Agric. Food Chem. .1997 ;(45):4487-4489

141. 1996 Hou, W. C. and Chang, W. H.. Pectinesterase-catalyzed firming effects during precooking of vegetables . J. Food Biochem. .1996 ;(20):397-416

會議論文 Conference Paper


1. 2004 呂岳霖,林音秀,劉燕雯,侯文琪. 麥門冬抗氧化活性的研究 . 第四十二次台灣農業化學會June 25, 臺北。 .2004

2. 2004 Lin YS,Liu YW,Hou WC. Monohydroxamates of aspartic acid and glutamic acid exhibited antioxidant and angiotensin converting enzyme inhibitory activities . 第四十二次台灣農業化學會。June 25, 臺北。 .2004

3. 2003 Wang CC,Hou WC. Cytotoxic activity of atractylenoide I on HL-60 from Atractylodes ovata accompanying the inhibition of Cu/Zn superoxide dismutase . 九十二年度中國藥學會。Dec. 7, 臺北。 .2003

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96 胺基酸衍生物生理活性探討--抗氧化與調節血壓機制之研究(1-3)
補助單位
行政院國家科學委員會
計畫名稱
96 97年度台、美、加暑期研究生研習計畫(Summer Program)
補助單位
行政院國家科學委員會
計畫名稱
96 山藥儲藏性蛋白質免疫調節活性研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
95 利用離體動物實驗與高血壓鼠模式，開發小葉葡萄應用於預防高血壓之研究
補助單位
行政院農業委員會
計畫名稱
95 甘藷胰蛋白酶抑制生理活性探討(3-3)
補助單位
行政院國家科學委員會
計畫名稱
95 山藥多醣生理活性探討(2-2)
補助單位
行政院國家科學委員會
計畫名稱
95 山藥多醣免疫調節活性之研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
94 甘藷胰蛋白酶抑制生理活性探討(2/3)
補助單位
行政院國家科學委員會
計畫名稱
94 山藥多醣生理活性探討1/2
補助單位
行政院國家科學委員會
計畫名稱
94 台灣特有種藥用植物對抗藥性金黃色葡萄球菌之抗菌活性篩選
補助單位
行政院國家科學委員會
計畫名稱
93 甘藷胰蛋白酶抑制生理活性探討(1/3)
補助單位
行政院國家科學委員會
計畫名稱
93 山藥黏質多醣抗氧化研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
92 山藥塊莖儲藏性蛋白質與其水解物中分離純化血管收縮素轉化酵素抑制劑的研究　　
補助單位
國泰醫療財團法人國泰綜合醫院
計畫名稱
92 山藥塊莖儲藏性蛋白質的研究(2/2)
補助單位
行政院國家科學委員會
計畫名稱
92 山藥儲藏性蛋白質--dioscorin, 對於自發性高血壓鼠降血壓效果的研究
補助單位
行政院國家科學委員會
計畫名稱
91 山藥塊莖儲藏性蛋白質的研究(1/2)
補助單位
行政院國家科學委員會
計畫名稱
91 不同品種麥門冬葉片抗氧化酵素及抗氧化活性小分子之研究?
補助單位
行政院國家科學委員會
計畫名稱
90 甘藷塊根儲藏性蛋白質生理特性的研究 (2)
補助單位
行政院國家科學委員會
計畫名稱
89 甘藷塊根儲藏性蛋白質生理特性的研究(I)
補助單位
行政院國家科學委員會