李仁愛(Lee, Jen-Ai)　教授

Email
jenai@tmu.edu.tw
現   職
臨床藥學學科 教授

學經歷

學　歷

畢業學校與學位[修業時間]
日本東京大學藥物化學研究所 博士
1996/10/01~1999/09/01
日本東京大學藥物化學研究所 碩士
1994/10/01~1996/09/01
私立臺北醫學院藥學系 學士
1988/09/01~1992/06/01

本校學術經歷

任職單位與職稱[起迄時間]
臨床藥學學科教授
2013/08/01~
臨床藥學學科副教授
2012/02/01~2013/07/31
藥學系副教授
2005/08/01~2012/01/31
藥學系助理教授
2000/02/01~2005/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
(舊)生技醫療產業研發博士學位學程教授
2016/09/01 ~ 2017/08/31
藥學系主任
2016/08/01 ~ 2019/07/31
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程教授
2013/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
台北市立仁愛醫院研究助理
1992/09/14~1993/03/18

專長與研究領域

學門領域
藥學
學術專長
高效能液相層析 (HPLC)
免疫分析 (immunoassay)
蛋白質體分析

論文著作

清冊下載

論文 Journal Paper


1. 2024 Wang JY,Kang JW,Wu CY,Peng TR,Liao LM,Lee MC, Lee JA, Chen SM. The effects of incretin-based therapies on weight reduction and metabolic parameters in children with obesity: A systematic review and meta-analysis . Obesity Reviews .2024

2. 2023 Enantioselective Analysis of Lactate, Hydroxybutyrates and Malate in Human Physiological Fluids Using a Three-Dimensional HPLC System . Chromatography .2023 ;(44):105-113

3. 2022 Chen Jin Hua,Lee Chih Hsin,Lee Meng Rui,Huang Pei-Yu,Yen Tzu Hsin,Lee Ming Chia, Tsai Ching Wen, Wang Jann Yuan, Lee Jen Ai. Bisphosphonate Use Is Not Associated With Tuberculosis Risk Among Patients With Osteoporosis: A Nationwide Cohort Study . Journal of Clinical Pharmacology .2022 ;(62):1412-1418

4. 2022 Tsai HM,Hsieh CL,Ishii C,Akita T,Mita M,Ide T, Lee JA, Hamase K. Two-Dimensional Chiral HPLC Analysis of Lactate, Hydroxybutyrates and Malate in Human Plasma . Chromatography .2022 ;(43):119-126

5. 2022 Lin PY,Chen CM,Lee JA,Cheng YC. Fabrication of biodegradable films using L-lactate as a chiral material to produce circularly polarized light . AIMS Bioengineering .2022 ;(9):337-347

6. 2021 Comparison of Antiviral Agents for Seasonal Influenza Outcomes in Healthy Adults and Children: A Systematic Review and Network Meta-analysis . JAMA Netw Open .2021 ;(4)

7. 2021 Computational tongue color simulation in tongue diagnosis . Color Research and Application .2021

8. 2021 Evaluation of the nephrotoxicity and safety of low-dose aristolochic acid, extending to the use of Xixin (Asurum), by determination of methylglyoxal and D-lactate . Journal of Ethnopharmacology .2021 ;(272)

9. 2021 Statin use and depression risk: A systematic review and meta-analysis . Journal of Affective Disorders .2021 ;(282):308-315

10. 2021 Development of a selective three-dimensional HPLC system for enantiomer discriminated analysis of lactate and 3-hydroxybutyrate in human plasma and urine . Journal of Pharmaceutical and Biomedical Analysis .2021 ;(195):1-7

11. 2021 Methylglyoxal Levels in Human Colorectal Precancer and Cancer: Analysis of Tumor and Peritumor Tissue . Life .2021 ;(11):1-12

12. 2021 Hsing CP,Lian JH,Lee JA,Fan HC,Chen SM,Lai CP*, Tsai YH. 長期照顧機構中中風住民潛在不適當的藥物使用：使用Beers標準觀察的個案 . 台灣公共衛生雜誌 .2021 ;(40):429-440

13. 2021 Chiral Analysis of Lactate in Various Food Samples Including Japanese Traditional Amber Rice Vinegar and the Developmental Changes During Fermentation Processes . Chromatography .2021 ;(42):151-158

14. 2021 Effects of various statins on depressive symptoms: A network meta-analysis . Journal of Affective Disorders .2021 ;(293):205-213

15. 2021 The Ginsenoside Rg1 Rescues Mitochondrial Disorders in Aristolochic Acid-Induced Nephropathic Mice . Life .2021 ;(11)

16. 2020 Dramatically enhanced mechanical properties of diamond-like carbon films on polymer substrate for flexible display devices via argon plasma pretreatment . Chemical Physics .2020 ;(529):1-5

17. 2020 Determination of temporal changes in serum and urinary lactate and 3-hydroxybutyrate enantiomers in mice with nephrotoxic serum nephritis by multi-dimensional HPLC . J Pharm Biomed Anal. .2020 ;(188):1-10

18. 2020 Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis . PLOS ONE .2020 ;(15):1-19

19. 2020 Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis . PLOS ONE .2020 ;(15):1-19

20. 2019 A novel preventive mechanism of gentamicin‐induced nephrotoxicity by atorvastatin . Biomedical Chromatography .2019 ;(33):1-10

21. 2019 Development of a Three-Dimensional HPLC System for the Simultaneous Determination of Lactate and 3-Hydroxybutyrate Enantiomers in Mammalian Urine . Chromatography .2019 ;(40):25-32

22. 2018 Hsieh CL,Koga R,Furusho A,Akita T,Mita M, Ide T, Lee JA*, Hamase K*.. Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrow-bore online two-dimensional high-performance liquid chromatography system . J Sep Sci .2018 ;(1):1-9

23. 2018 Huang YS,Wang SH,Chen SM,Lee JA. Metabolic profiling of metformin treatment for low-level Pb-induced nephrotoxicity in rat urine . Scientific Reports .2018 ;(8):1-13

24. 2018 Proteomics analysis of altered proteins in kidney of mice with aristolochic acid nephropathy using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry method . Biomed Chromatogr .2018 ;(32)

25. 2018 Effects of metallic interlayers on the performance of nanocrystalline diamond metal-semiconductor-metal photodetectors . Applied Surface Science .2018 ;(455):581-590

26. 2017 Wang WC,Chou CK,Chuang MC,Li YC,Lee JA. Elevated levels of liver methylglyoxal and D-lactate in early-stage hepatitis in rats . Biomedical Chromatography .2017 ;(e4039):1-8

27. 2016 Huang YS,Li YC,Tsai PY,Lin CE,Chen CM,Chen SM, Lee JA. Accumulation of methylglyoxal and D-lactate in Pb-induced nephrotoxicity in rats . Biomedical Chromatography .2016 ;(31):1-10

28. 2015 Chou CK,Li YC,Chen SM,Shih YM,Lee JA. Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway . BioMed Research International .2015 ;(2015):1-8

29. 2015 Chou CK,Chen SM,Li YC,Huang TC,Lee JA. Low-molecular-weight chitosan scavenges methylglyoxal and N (ε)-(carboxyethyl)lysine, the major factors contributing to the pathogenesis of nephropathy. . SpringerPlus .2015 ;(4):1-7

30. 2015 Chou CK,Lee YT,Chen SM,Hsieh CW,Huang TC,Li YC, Lee JA. Elevated urinary d-lactate levels in patients with diabetes and microalbuminuria . J Pharm Biomed Anal. .2015 ;(116):65-70

31. 2015 Liu SL,Oyama T,Miyoshi Y,Sheu SY,Mita M,Ide T, Lindner W, Hamase K, Lee JA. Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples . J Pharm Biomed Anal. .2015 ;(116):80-85

32. 2014 Huang TC,Chen SM,Li YC,Lee JA. Increased renal semicarbazide-sensitive amine oxidase activity and methylglyoxal levels in aristolochic acid-induced nephrotoxicity . Life Sciene .2014 ;(114):4-11

33. 2014 Lin CR,Wei DH,BenDao MK,Chang HM,Chen WE,Lee JA. Effects of Surface Modification of Nanodiamond Particles for Nucleation Enhancement during Its Film Growth by Microwave Plasma Jet Chemical Vapour Deposition Technique . Advances in Materials Science and Engineering .2014 ;(2014):1-5

34. 2013 Hsu YW,Chien HC,Liang CC,Yang KD,Chang WP,Lee JA, Kuo HC, Chang WC. Stromal Interaction Molecule 1 Polymorphisms are Associated with Coronary Artery Dilation but not with Aneurysm Formation in Patients with Kawasaki Disease. . J Exp Clin Med. .2013 ;(5):73-76

35. 2013 Li YC,Shih YM,Lee JA. Gentamicin caused renal injury deeply related to methylglyoxal and Nɛ-(carboxyethyl)lysine (CEL). . Toxicol Lett. .2013 ;(219):85-92

36. 2013 Huang TZ,Chen SM,Li YC,Lee JA. Urinary D-lactate levels reflect renal function in aristolochic acid-induced nephropathy in mice. . Biomed Chromatogr. .2013 ;(27):1100-1106

37. 2012 Chiang YC,Lin YM,Lee JA,CN Lee,Chen HY. Tobacco consumption is a reversible risk factor associated with reduced successful treatment outcomes of anti-tuberculosis therapy . International Journal of Infectious Disease .2012 ;(16):130-135

38. 2012 Li YC,Tsai SH,Chen SM,Chang YM,Huang TC,Huang YP, Chang CT, Lee JA. Aristolochic acid-induced accumulation of methylglyoxal and Ne-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy . Biochem. Biophys. Res. Commun. .2012 ;(423):832-837

39. 2012 Liao WH,Lin CR,Wei DH,Shen YR,Li YC,Lee JA, Liang CY. Concurrent improvement in biocompatibility and bioinertness of diamond-like carbon films with nitrogen doping . J Biomed Mater Res A .2012 ;(100):3151-3156

40. 2012 Tsai PY,Chen SM,Chen HY,Li YC,Imai K,Hsu KY, Lee JA. Proteome analysis of altered proteins in streptozotocin-induced diabetic rat kidney using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry method . Biomed Chromatogr .2012 ;(27):382-389

41. 2012 Tseng IJ,Sheu SY,Lin PY,Lee JA,Ou KL,Lee LW. Synthesis and Evaluation of Cantharidinimides on Human Cancer Cells . .2012 ;(4):280-283

42. 2012 Chen CM*,Lee JA†,Huang TC. Construction of a light‐emitting diode fluorescence detector for high‐performance liquid chromatography and its application to fluorometric determination of L‐3‐hydroxybutyrate . Biomed. Chromatogr. .2012 ;(26):256-260

43. 2011 Chang YM,Chang CT,Huang TC,Chen SM,Lee JA,Chung YC. Effects of low molecular weight chitosans on aristolochic acid-induced renal lesions in mice . Food Chemistry .2011 ;(129):1751-1758

44. 2011 Hsu WY,Kuo CY,Fukushima T,Imai K,Chen CM,Lin PY, Lee JA. Enantioselective determination of 3-hydroxybutyrate in the tissues of normal and streptozotocin-induced diabetic rats of different ages . Journal of Chromatography B .2011 ;(879):3331-3336

45. 2011 Lee JA,Liu H.E.,Huang WI,Lee CN,Yu MC,Chang JH, Hsu HL, Lu PC, Chen HY. Association of low activity of UGT1A7 with lung cancer in Taiwan: a preliminary case control study . J. Food Drug Anal. .2011 ;(19):403-409

46. 2011 Lin MH,Chen HY,Liao TH,Huang TC,Chen CM,Lee JA. Determination of time-dependent accumulation of D-lactate in the streptozotocin-induced diabetic rat kidney by column-switching HPLC with fluorescence detection . Journal of Chromatography B .2011 ;(879):3214-3219

47. 2010 Chen CM,Huang TC,Lee JA*. The Elevation of L-3-Hydroxybutyrate Concentrations in the Serum of Aristolochic Acid-Treated Mice . Int. J. Bio-Sci. and Bio-Techno. .2010 ;(2):25-30

48. 2010 Chen CM*,Yen CF,Lee JA. The Development of a Column-Switching High-Performance Liquid Chromatograph System for Chiral Seperation of Mouse urinary D,L-Lactate. . Int. J. Bio-Sci. and Bio-Techno. .2010 ;(2):31-38

49. 2010 Hsu WY,Fukushima T,Imai K,Chen CM,Lee JA*. Fluorometric determination of L-3-hydroxybutyrate in normal and diabetic rat tissues. . Luminescence .2010 ;(25):233-234

50. 2010 Tsai PY,Imai K,Lee JA*. Proteome analysis of diabetic-related proteins in rat kidney by FD-LC-MS/MS method . Luminescence .2010 ;(25):238-238

51. 2010 Chen TH,Chen SM,Chang WS,Imai K,Lee JA*. Proteome analysis of Altered Proteins in Cisplatin Induced Mouse Acute Kidney Injury (AKI) using FD-LC-MS/MS method . Luminescence .2010 ;(25):257-258

52. 2009 Chen CM*,Lee JA,Yen CF. Improvement in Resolution of Laser Capture Microdissection Using Near-Field Probe to Capture Nanoparticles . IEEE TRANSACTIONS ON NANOBIOSCIENCE .2009 ;(8):113-119

53. 2009 Chen CM,Uen YH,Kuo CY,Huang TZ,Lee JA. Fluorimetric Determination of L-3-Hydroxybutyrate Concentrations in the Serum of Normal and Aristolochic Acid-Treated Mice . Communications in Computer and Information Science .2009 ;(57):63-68

54. 2008 Liu HJ,Hsiao PY,Li CC,Lee JA,Chen HY*. NAT2*7 allele is a potential risk factor for adult brain tumors in Taiwanese population . Cancer Epidemiol Biomarkers Prev. .2008 ;(17):661-665

55. 2008 Chou YC,Tsai YC,Chen CM,Chen SM,Lee JA*. Determination of lipoprotein lipase activity in post heparin plasma of streptozotocin-induced diabetic rats by high performance liquid chromatography with fluorescence detection . Biomedical Chromatography .2008 ;(22):502-510

56. 2006 Hsiao FY,Lee JA,Huang WF,Chen SM,Chen HY*. Safe Medication Use Survey of College Students in Taiwan . American Journal of Pharmaceutical Education .2006 ;(70):30-1-30-7

57. 2006 Chen CM,Shen CY,Chen YC,Lee JA*. The development of a hollow cap thermoplastic film for laser capture microdissection with a near field fiber tip . Key Eng. Mater. .2006 ;(326):731-734

58. 2006 Tsai YC,Chou YC,Wu AB,Hu CM,Chen CY,Chen FA, Lee JA*. Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes . Life Sciences .2006 ;(78):1385-1391

59. 2006 Chen CM,Shen CY,Chen YC,Lee JA. The development of a hollow cap thermoplastic film for laser capture microdissection with a near field fiber tip . Key Eng. Mater. .2006 ;(326):731-734

60. 2006 Hsu YH,Liou YB,Lee JA,Chen CY,Wu AB*. Assay of naproxen by high-performance liquid chromatography and identification of its photoproducts by LC-ESI MS . Biomed. Chromatogr. .2006 ;(20):787-793

61. 2006 Liou YB,Chen FA,Lee JA,Ho HO,Wu AB*. Development of an RPLC-based Method for Measurement of Indoprofen Stability and Validation of the Method . Chin. J. Chem. .2006 ;(24):1570-1574

62. 2005 Chen CM,Tsai YC,Fukushima T,Imai K,Lee JA*. Enantiomeric determination of D-, L-lactate in diabetic rat urine using a column-switching HPLC . Proc. of SPIE .2005 ;(5852):954-958

63. 2005 Chen GL,Lee JA,Lu TW,Chen ZC,Chen CM*. Measurment of blood velocity using Laser Doppler method for the designing module . Proc. of SPIE .2005 ;(5852):328-332

64. 2005 Yen CF,Lee JA,Chen CM*. The positional capture experiments of the LCM using near field fiber probe . Proc. of SPIE .2005 ;(5852):844-848

65. 2005 Lee JA*,Tsai YC,Chen HY,Wang CC,Chen SM,Fukushima T , Imai K. Fluorimetric Determination of D-Lactate in Normal and Diabetic Rat Urine Using a Column-Switching High-Performance Liquid Chromatography . Analytica. Chemica. Acta. .2005 ;(534):185-191

66. 2003 Tsai YC, Liao TH, and LEE JA*. Identification of L-3-Hydroxybutyrate as an Original Ketone Body in Rat Serum by Column-Switching High-Performance Liquid Chromatography and Fluorescence Derivatization . Anal. Biochem. .2003 ;(319):34-41

67. 2003 Hasegawa H., FukushimaT., Lee JA., Tsukamotoc K., Moriyad K., Onoe Y. and Imai K.*. Determination of serum D- and L-lactic acids in normal subjects and diabetic patients by column-switching HPLC with pre-column fluorescence derivatization . Anal. and Bioanal. Chem. .2003 ;(377):886-891

68. 2001 Fukushima T, Lee JA, Korenaga T, Ichihara H, Kato M, Imai K. Simultaneous determination of D-lactic acid and 3-hydroxybutyric acid in rat plasma using a column-switching HPLC with fluorescent derivatization with 4-nitro-7-piperazino-2,1,3-benzoxadiazole (NBD-PZ) . Biomedical Chromatography .2001 ;(15):173-180

69. 2001 Long ZQ,Sekine M,Nimura N,Lee JA,Imai K,Iwatsubo T , Homma H*. Immunocytochemical study of D-aspartate in the 2068 rat pheochromocytoma cell line . Bioimages .2001 ;(9):61-67

70. 2001 Long Z, Lee JA, Okamoto T, Sekine M, Nimura N, Imai K, Yohda M, Maruyama T, Sumi M, , Kamo N, Yamagishi A, Oshima T, Homma H*. Occurrence of D-Amino Acids and a Pyridoxal 5'-Phosphate-Dependent Aspartate Racemase in the Acidothermophilic Archaeon, Thermoplasma acidophilum . Biochem. Biophys. Res. Commun. .2001 ;(281):317-321

71. 2001 Jen-Ai Lee, Zhiqun Long, Noriyuki Nimura, Takeshi Iwatsubo, Kazuhiro Imai* and Hiroshi Homma. Localization, transport and uptake of D-aspartate in the rat adrenal and pituitary glands . Arch. Biochem. Biophys. .2001 ;(385):242-249

72. 2000 Zhiqung Long, Jen-Ai Lee, Taizo Okamoto, Noriyuki Nimura, Kazuhiro Imai and Hiroshi Homma*. D-Aspartate in a prolactin-secreting clonal strain of rat pituitary tumor cells (GH3) . Biochem. Biophys. Res. Commun. .2000 ;(276):1143-1147

73. 1999 Jen-Ai Lee, Hiroshi Homma, Ken Tashiro, Takeshi Iwatsubo and Kazuhiro Imai. D-Aspartate localization in the rat pituitary gland and retina . Brain Res. .1999 ;(838):193-199

74. 1999 Yoshiko Nagata, Hiroshi Homma, Jen-Ai Lee, and Kazuhiro Imai. D-Aspartate stimulation of testosterone synthesis in rat Leydig cells . FEBS Lett. .1999 ;(444):160-164

75. 1998 Kumiko Sakai, Hiroshi Homma, Jen-Ai Lee, Takeshi Fukushima, Tomofumi Santa, Ken Tashiro, Takeshi Iwatsubo, and Kazuhiro Imai. Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system . Brain Res. .1998 ;(808):65-71

76. 1998 Zhiqun Long, Hiroshi Homma, Jen-Ai Lee, Takeshi Fukushima, Tomofumi Santa, Takeshi Iwatsubo, Ryo-hei Yamada, and Kazuhiro Imai. Biosynthesis of D-aspartate in mammalian cells . FEBS Lett. .1998 ;(434):231-235

77. 1998 Yuki Takigawa, Hiroshi Homma, Jen-Ai Lee, Takeshi Fukushima, Tomofumi Santa, Takeshi Iwatsubo, and Kazuhiro Imai. D-Aspartate uptake into cultured rat pinealocytes and the concomitant effect on L-aspartate levels and melatonin secretion . Biochem. Biophys. Res. Commun. .1998 ;(248):641-647

78. 1998 Kumiko Sakai, Hiroshi Homma, Jen-Ai Lee, Takeshi Fukushima, Tomofumi Santa, Ken Tashiro, Takeshi Iwatsubo, and Kazuhiro Imai. Localization of D-aspartic acid in elongate spermatids in rat testis . Arch. Biochem. Biophys. .1998 ;(351):96-105

79. 1997 Kumiko Sakai, Hiroshi Homma, Jen-Ai Lee, Takeshi Fukushima, Tomofumi Santa, Ken Tashiro, Takeshi Iwatsubo, and Kazuhiro Imai. D-aspartic acid localization during postnatal development of rat adrenal gland . Biochem. Biophys. Res. Commun. .1997 ;(235):433-436

80. 1997 Jen-Ai Lee, Hiroshi Homma, Kumiko Sakai, Takeshi Fukushima, Tomofumi Santa, Ken Tashiro, Takeshi Iwatsubo, Masayoshi Yoshikawa, and Kazuhiro Imai. Immunohistochemical localization of D-aspartate in the rat pineal gland . Biochem. Biophys. Res. Commun. .1997 ;(231):505-508

會議論文 Conference Paper


1. 2016 Huang YS,Yang SC,Chen SM,Imai K,Lee JA. DIFFERENTIAL PROTEOMICS ANALYSIS OF LEAD-INDUCED NEPHROTOXICITYIN RATS WITH METFORMIN TREATMENT USING FLUOROGENIC DERIVATIZATION LC-MS/MS METHOD . Proceedings of The XVII International Symposium on Luminescence Spectrometry (ISLS 2016) .2016

2. 2014 TZ Huang,Li YC,Chen SM,Lee YJ,Tien LT,Lee JA. Ameliorative Effects of Metformin on Aristolochic AcidInduced Renal Toxicity in Mice Due to Its Ability to Control Methylglyoxal and NMethylglyoxal and NMethylglyoxal and Nε-(Carboxymethyl)Lysine Accumulation . .2014 ;(138):543-543

3. 2014 Liu SL,Lee JA,Sheu SY,Oyama T,Miyoshi Y,Mita M, Hamase K. Development of a two-dimensional HPLC system for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers . .2014

4. 2014 Lee JA,Wu HY,Chen SM,Huang YS,Chen CM,Imai K. Proteome analysis of Cisplatin nephrotoxicity in mice with (+)-Catechin treatment by FD-LC-MS/MS method . Proceedings of XVI International Symposium of Luminescence Spectrometry .2014

5. 2005 Shen CY,Lee JA,Chen CM*. The Development of a Thermoplastic Film for Laser Capture Microdissection System with Near Field Tips . 2005 IEEE LEOS Annual Meeting Conference Proceedings .2005

6. 2005 蔡屹喬,周郁晴,福島 健,今井 一洋,李仁愛*. 心臓におけるL-3-ヒドロキシブチレート含量とブドウ糖代謝への影響 . 日本薬学会125年会 .2005

7. 2005 顏畿府,李仁愛,陳建銘*. カラムスイッチングHPLCの全自動化 . 日本薬学会125年会 .2005

8. 2004 顏畿府,李仁愛,沈傳宇,陳建銘*. 探針式雷射顯微摘取系統 . .2004

9. 2004 陳郭良,李仁愛,呂東武,陳建銘*. 小型模組化雷射都卜勒血液流速計(第二報) -稀釋血液於光學桌上量測之條件分析與結果 . .2004

10. 2004 Chou YC,Tsai YC,Lee JA*. An assay for determination of lipoprotein lipase (LpL) activity in the post-heparin plasma of rats by high performance liquid chromatography with fluorescence detection . The Proceedings of 2004 Annual Meeting of Pharmaceutical Society of ROC .2004

11. 2004 Yen CF,Lee JA,Chen CM*. New Construct of Laser Capture Microdissection (LCM) Using Near-Field Optical Tips . The 10th International Microoptics Conference (MOC’4) (September 1-3), Proceeding D5 .2004

12. 2004 Yen CF,Lee JA,Chen CM*. The positional capture experiments of the LCM using near field fiber probe . The 3rd International Conference on Experimental Mechanics 2004, Singapore, in press .2004

13. 2004 Chen GL,Lee JA,Lu TW,Chen ZC,Chen CM*. Measurment of blood velocity using Laser Doppler method for the designing module . The 3rd International Conference on Experimental Mechanics 2004, Singapore, in press. .2004

14. 2004 Chen CM,Tsai YC,Fukushima T,Imai K,Lee JA*. Enantiomeric determination of D-, L-lactate in diabetic rat urine using a column-switching HPLC . The 3rd International Conference on Experimental Mechanics 2004, Singapore, in press. .2004

15. 2003 Chou YC,Chen SM,Lu YL,Tsai YC,Chung PY,Lee JA*. Fluorimetric determination of D-lactate in the urine of nephrotoxic serum-induced nephritis mice by column-switching high performance liquid chromatography . The Proceedings of 2003 Annual Meeting of Pharmaceutical Society of ROC .2003

16. 2003 陳昭誠,陳恆殷,李仁愛,呂東武,陳建銘*. 小型模組化雷射都卜勒血液流速計(第一報) . 2003台灣光電科技研討會 Proceeding 2 .2003 ;(2):182-184

17. 2002 Lee JA*. D-Aspartate in mammalian tissues . The Proceedings of 2002 Annual Meeting of Pharmaceutical Society of ROC .2002

18. 2002 Lee JA*,Wang CC,Tsai YC,Liao TH. Fluorimetric Determination of D-Lactate in Rat Urine Using a Column-Switching High-Performance Liquid Chromatography . The Proceedings of 2002 Annual Meeting of Pharmaceutical Society of ROC .2002

19. 2002 Tsai YC,Wang CC,Liao TH,Lee JA*. Enantiomeric Determination of L- and D-3-Hydroxybutyrate in Rat Serum Using High-Performance Liquid Chromatography with Fluorescent Derivatization . The Proceedings of 2002 Annual Meeting of Pharmaceutical Society of ROC .2002

20. 2002 Liao TH,Tsai YC,Wang CC,Lee JA*. Fluorimetric Determination of D-Lactate in Rat Liver Microdialysate by Column-Switching High-Performance Liquid Chromatography . The Proceedings of 2002 Annual Meeting of Pharmaceutical Society of ROC .2002

21. 2001 隆志群,李仁愛,岡本泰三,二村典行,今井一洋,本間浩*. ロラクチン分泌性の下垂体培養細胞株（GH3細胞）におけるD-アスパラギン酸 . 日本薬学会121年会 .2001 ;(PC-I)

22. 2001 福島健,長谷川久紀,田邊舞子,服部晃広,李仁愛,今井一洋*. HPLC-蛍光検出を用いる光学活性分子の高感度光学分割定量 . バイオメディカル分析科学シンポジウム .2001

23. 2001 Lee JA*. D-Aspartate in the rat endocrine organs: Its localization and developmental regulation . The Proceedings of 2001 ROC-Japanese Symposium on Biopharmaceutic, Traditional Medicine and Functional Food .2001

24. 2001 Lee JA*. Biosynthesis of D-aspartate in rat pituitary tumor cells (GH3) . The Proceedings of 2001 Annual Meeting of Pharmaceutical Society of ROC .2001

25. 2000 Lee JA*. D-Aspartate in mammalian tissues . The Proceedings of 2002 Annual Meeting of Pharmaceutical Society of ROC .2000

26. 2000 李仁愛,岩坪威,本間浩,今井一洋*. ラット副腎と下垂体におけるグルタミン酸トランスポーターの発現とD-アスパラギン酸含量との相関 . 日本薬学会第120年会 .2000 ;(PC15)

27. 2000 福島健,李仁愛,是永卓識,市原秀晃,今井一洋*. HPLCによるD-乳酸および3‐ヒドロキシ酪酸の高感度定量法の開発 . クロマトグラフィー科学会 .2000

書籍 Book


1. 2006 Konno R.,Bru(u umlaut)ckne H.,D'Aniello A.,Fisher G.,Fujii N.,Homma H., Lee JA. D-Amino Acids: A New Frontier in Amino Acid and Protein Research -Practical Methods and Protocols- . in press .2006

2. 2005 李仁愛,李貽琳,張學偉. 生物化學─生命的分子基礎 （滄海書局） . .2005

3. 2003 陳永璋,陳建銘,龔皇光,李仁愛. 統計方法與品質管制 . (立榮書局) .2003

研究計畫

計畫名稱
113 以圓二色性光譜與核磁共振光譜評估人參皂苷對馬兜鈴酸腎損傷之保護效果
補助單位
國家科學及技術委員會
計畫名稱
112 貴機構依本會「補助國內專家學者出席國際學術會議」申請 費用補助案(出席人員：藥學系（所）李仁愛教授)
補助單位
國家科學及技術委員會
計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費 用補助案(研究生：藥學系（所）碩士班黃熙之君)
補助單位
國家科學及技術委員會
計畫名稱
111 利用代謝體學與蛋白質體學探討醣化終產物在多發性硬化症病人中的角色與機轉
補助單位
國家科學及技術委員會
計畫名稱
109 胃腸科相關癌症之差異蛋白質體與致病機轉之研究
補助單位
科技部
計畫名稱
107 利用三維液相層析系統同時分離小鼠尿液中乳酸與3-羥基丁酸之鏡像異構物
補助單位
科技部
計畫名稱
105 第17屆發光光譜學國際研討會
補助單位
科技部
計畫名稱
105 柴胡皂?對腎毒血清誘導的小鼠腎炎之蛋白質體的影響
補助單位
計畫名稱
105 105年11月22日至11月25日辦理「第17屆發光光譜學國際研討會」
補助單位
臺北市政府秘書處
計畫名稱
105 105年11月22日至25日在台舉辦「第17屆發光光譜學國際研討會」
補助單位
外交部
計畫名稱
104 二甲雙胍對鉛離子誘導之腎損傷大鼠之蛋白質體的影響
補助單位
科技部
計畫名稱
103 含銀類鑽碳薄膜輔助高效能葡萄糖生物感測器之設計及性能
補助單位
臺北科技大學
計畫名稱
102 Metformin（滅糖敏錠）對大鼠腎損傷之蛋白質體的影響
補助單位
行政院國家科學委員會
計畫名稱
102 METFORMIN（滅糖敏錠）對大鼠腎損傷之蛋白質體的影響
補助單位
科技部
計畫名稱
102 含鈦類鑽碳薄膜之合成、特性及應用於植入式人工關節之研究
補助單位
臺北科技大學
計畫名稱
101 以螢光高效能液相層析串聯質譜法分析藥物對小鼠腎損傷之蛋白質體的影響
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
101 含氮無氫類鑽碳薄膜之合成、特性及應用於植入式生醫元件之研究
補助單位
臺北科技大學
計畫名稱
99 腎炎小鼠的腎臟蛋白變化與尿中D-乳酸含量
補助單位
行政院國家科學委員會
計畫名稱
98 Acteoside與其類似物對糖尿病腎病變的保護效果
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)
計畫名稱
98 腎炎小鼠的腎臟蛋白變化與尿中D-乳酸含量
補助單位
行政院國家科學委員會
計畫名稱
98 奈米顯微摘取生物樣本的螢光含量分析
補助單位
臺北醫學大學
計畫名稱
96 以尿中D-乳酸含量評估小鼠腎症之進程並探討腎臟中D-乳酸之再吸收
補助單位
行政院國家科學委員會
計畫名稱
96 腎炎小鼠的腎臟蛋白變化與尿中D-乳酸含量
補助單位
行政院國家科學委員會
計畫名稱
95 Meisoindigo 在膠質母細胞瘤之分子機轉
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
95 生物檢體中游離甲狀腺素之高效能液相層析分析法的開發及其應用
補助單位
行政院國家科學委員會
計畫名稱
94 抗結核病藥物不良反應及基因學監測
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
94 大白鼠組織中脂蛋白脂解酶定量法的開發及L-3羥基丁酸對其活性的影響
補助單位
行政院國家科學委員會
計畫名稱
93 D-乳酸對大白鼠組織中自由基濃度的影響
補助單位
行政院國家科學委員會
計畫名稱
92 大白鼠組織中D-乳酸之研究
補助單位
行政院國家科學委員會
計畫名稱
91 大白鼠組織中 L-3-羥基丁酸之研究
補助單位
行政院國家科學委員會
計畫名稱
90 生物體內D-、L-乳酸及D-、L-3-羥基丁酸鏡像異構物之高效能液相層析分析法的開發
補助單位
行政院國家科學委員會
計畫名稱
89 關於大白鼠腦下線細胞中D-天門冬胺酸之生合成的研究
補助單位
行政院國家科學委員會