黃惠美(Huang, Huei-Mei) 教授

Email
cmbhhm@tmu.edu.tw
現   職
醫學科學研究所 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國防醫學院生命科學研究所 博士
1993/08/01~1999/01/01
私立輔仁大學生物醫學研究所 碩士
1991/09/01~1993/06/01
私立中國文化大學海洋生物學系 學士
1988/09/01~1990/06/01

本校學術經歷

任職單位與職稱[起迄時間]
醫學科學研究所教授
2019/02/01~
醫學科學研究所副教授
2007/08/01~2019/01/31
細胞及分子生物研究所副教授
2006/08/01~2007/07/31
細胞及分子生物研究所助理教授
2000/04/15~2006/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際醫學研究碩士學位學程副教授
2018/02/01 ~
國際醫學研究博士學位學程副教授
2018/02/01 ~
(舊)細胞治療與再生醫學國際博士學位學程籌備處副教授
2018/02/01 ~
國際醫學研究博士學位學程副教授
2016/11/01 ~ 2017/10/31
國際醫學研究碩士學位學程副教授
2016/11/01 ~ 2017/10/31
生化學科副教授
2009/09/01 ~

其它經歷

任職單位與職稱[起迄時間]
中研院生物醫學所博士後研究員
1999/01/18~2000/04/14
台大醫院小兒科研究助理
~

專長與研究領域

學門領域
細胞分化學 (Cell Differentiation)
細胞凋亡學 (Apoptosis)
腫瘤生物學 (Tumor Biology)
分子生物學 (Molecular Biology)
生理
醫學之生化及分子生物
學術專長

論文著作

清冊下載


1. 2024 MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease . Journal of Cellular and Molecular Medicine .2024 ;(28):e18229

2. 2022 Activin A downregulates the CD69-MT2A axis via p38MAPK to induce erythroid differentiation that sensitizes BCR-ABL-positive cells to imatinib . Experimental cell research .2022 ;(417):1-11

3. 2022 Ju-Fang Liu,Yinshen Wee,Shen-Dean Luo,Shwu-Fen Chang,Shihai Jia,Sheng-Wei Feng, Huei-Mei Huang, Jiann-Her Lin, Ching-Shuen Wang. Proanthocyanidins-loaded complex coacervates-based drug delivery attenuates oral squamous cell carcinoma cells metastatic potential through down-regulating the Akt signaling pathway . Frontiers in Oncology .2022

4. 2020 Buyandelger B,Bar Eli E,Hung KS,Chen RM,Chiang YH,Liou JP, Huang HM, Wang JY*. Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53 . International Journal of Biological Sciences .2020

5. 2019 Lee YC,Sue YM,Lee CK,Huang HM,He JJ,WangYS, JuanSH. Synergistic effects of cAMP–dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes . Phytomedicine .2019 ;(55):255-263

6. 2019 Lin CL,Huang HM,Hsieh CL,Fan CK,Lee YL.. Jagged1-expressing adenovirus-infected dendritic cells induce expansion of Foxp3+ regulatory T cells and alleviate T helper type 2-mediated allergic asthma in mice. . Immunology .2019 ;(156):199-212

7. 2019 Chen YC,Chen BC,Huang HM,Lin SH,Lin CH. Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin . J Cell Physiol .2019

8. 2019 Chiu SP,Batsaikhan B,Huang HM,Wang JY. Application of Electric Cell-Substrate Impedance Sensing to Investigate the Cytotoxic Effects of Andrographolide on U-87 MG Glioblastoma Cell Migration and Apoptosis . Sensors (Basel) .2019 ;(19)

9. 2018 Huang SY,Liu YH,Chen YJ,Yeh YY,Huang HM*. CD69 partially inhibits apoptosis and erythroid differentiation via CD24, and their knockdown increase imatinib sensitivity in BCR-ABL-positive cells . J Cell Physiol .2018 ;(233):7467-7479

10. 2018 Yang JM#,Huang HM#,Cheng JJ,Huang CL,Lee YC,Chiou CT, Huang HT, Huang NK, Yang YC. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway . Toxicology .2018 ;(410):65-72

11. 2018 Lee CH,Lin YF,Chen YC,Wong SM,Juan SH,Huang HM*. MPT0B169 and MPT0B002, new tubulin inhibitors, induce growth inhibition, G2/M cell cycle arrest, and apoptosis in human colorectal cancer cells . Pharmacology .2018 ;(102):262-271

12. 2018 Chiu HW,Chang JS,Lin HY,Lee HH,Kuei CH,Lin CH, Huang HM*, Lin YF*. FBXL7 upregulation predicts a poor prognosis and associates with a possible mechanism for paclitaxel resistance in ovarian cancer . J Clin Med .2018 ;(7):1-14

13. 2018 Shao-Ping C,Huang HM,Shen SC,Lee WR,Chen YC. Nilotinib induction of melanogenesis via reactive oxygen species-dependent JNK activation in B16F0 mouse melanoma cells . Exp Dermatol .2018 ;(27):1388-1394

14. 2017 Chiang CY,Lee CC,Fan CK,Huang HM,Chiang BL,Lee YL. Osthole treatment ameliorates Th2-mediated allergic asthma and exerts immunomodulatory effects on dendritic cell maturation and function. . Cell and Molecular Immunology .2017 ;(14):1-13

15. 2017 Yeh YY,Liou JP,Lee YL,Lin JY,Huang HM*. MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells . Invest New Drugs .2017 ;(35):427-435

16. 2016 Wang CC,Liu HE,Lee YL,Huang YW,Chen YJ,Liou JP, Huang HM. MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation . Tumor Biology. .2016 ;(37):6065-6072

17. 2016 Wong SM,Liu FH,Lee YL,Huang HM*. MPT0B169, a New Antitubulin Agent, Inhibits Bcr-Abl Expression and Induces Mitochondrion-Mediated Apoptosis in Nonresistant and Imatinib-Resistant Chronic Myeloid Leukemia Cells . PLoS One .2016 ;(11):e0148093-e0148093

18. 2016 Chen CW,Lee YL,Liou JP,Liu YH,Liu CW,Chen TY, Huang HM*. A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells . Apoptosis .2016 ;(21):1008-1018

19. 2015 Shieh YH#,Huang HM#,Wang CC,Lee CC,Fan CK,Lee YL. Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice . Int Immunopharmacol .2015 ;(24):383-391

20. 2015 Lee CC,Wang CC,Huang HM,Lin CL,Leu SJ,Lee YL. Ferulic acid induces Th1 responses by modulating the function of dendritic cells and ameliorates Th2-mediated allergic airway inflammation in mice . Evid Based Complement Alternat Med .2015 ;(2015):678487

21. 2014 Huang YW,Lee WH,Tsai YH,Huang HM*. Activin A induction of erythroid differentiation sensitizes K562 chronic myeloid leukemia cells to a subtoxic concentration of imatinib (doi:10.1152/ajpcell.00130.2013) . American Journal of Physiology - Cell Physiology .2014 ;(306):C37-44

22. 2014 Lee WH,Chung MH,Tsai YH,Chang JL,Huang HM*. Interferon-γ suppresses activin A/NF-E2 induction of erythroid gene expression through the NF-κB/c-Jun pathway . Am J Physiol Cell Physiol .2014 ;(306):C407-414

23. 2014 Chen CW,Chung MH,Chang JL,Liu CH,Huang HM*. Role of c-Jun in Tumor Necrosis Factor-Alpha Inhibition of Activin A-Mediated Erythroid Gene Expression in Erythroleukemia K562 Cells . J Exp Clin Med .2014 ;(6):222-227

24. 2013 Lee WH,Liu H Eugene,Chang JY,Liou JP,Huang HM. MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells . Pharmacology .2013 ;(92):90-98

25. 2013 Huang HM,Hsiao G,Fan CK,Lin CL,Leu SJ,Chiang BL, Lee YL. Notch Ligand Delta-Like 4-Pretreated Dendritic Cells Alleviate Allergic Airway Responses by Enhancing IL-10 Production (doi:10.1371/journal.pone.0063613) . PLOS ONE .2013 ;(8):1-14

26. 2013 Lee YL,Chen CW,Liu FW,Huang YW,Huang HM. Aclacinomycin A sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation (doi:10.1371/journal.pone.0061939) . PLOS ONE .2013 ;(8):1-9

27. 2011 Lin YF,Leu SJ,Huang HM,Tsai YH. Selective Activation of Specific PKC Isoforms Dictating the Fate of CD14+ Monocytes Towards Differentiation or Apoptosis . Journal of Cellular Physiology .2011 ;(226):122-131

28. 2011 Chiu LH,Yeh TS,Huang HM,Leu SJ,Yang CB,Tsai YH. Diverse effects of type II collagen on osteogenic and adipogenic differentiation of mesenchymal stem cells . Journal of Cellular Physiology (accepted) .2011 ;(0):0-0

29. 2010 Lee WH,Liu FH,Lee YL,Huang HM*. Interferon-alpha induces the growth inhibition of human T cell leukemia line Jurkat through p38alpha and p38beta . Journal of Biochemistry .2010 ;(147):645-650

30. 2010 Huang HM*,Li YC,Chung MH. Activin A induction of erythroid differentiation through MKK6-p38α/p38β pathway is inhibited by follistatin . Journal of Cellular Physiology .2010 ;(223):687-694

31. 2009 Huang HM*,Liu JC. c-Jun blocks cell differentiation but not growth inhibition or apoptosis of chronic myelogenous leukemia cells induced by STI571 and by histone deacetylase inhibitors . Journal of Cellular Physiology .2009 ;(218):568-574

32. 2009 Lee WH,Liu FH,Lin YC,Huang SY,Lin H,Liao WJ, Huang HM*. JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis . Journal of Cellular Biochemistry .2009 ;(106):929-936

33. 2008 Chen CH,Lin YC,Liu FH,Chang JL,Huang HM. Basic fibroblast growth factor inhibits p38-mediated cell differentiation and growth inhibition by activin A but not by histone deacetylase inhibitors in CML cells . Annals of Hematology .2008 ;(87):175-182

34. 2007 Hsieh CW,Lan JL,Meng Q,Cheng YW,Huang HM,Tsai JJ. Eosinophil Apoptosis Induced by Fungal Immunomodulatory Peptide-fve via Reducing IL-5 Alpha receptor . J Formos Med Assoc .2007 ;(106):36-43

35. 2006 Huang HM,Lee YL,Chang TW. JAK1 N-terminus binds to conserved Box1 and Box2 motifs of cytokine receptor common beta subunit but signal activation requires JAK1 C-terminus . J. Cell Biochem. .2006 ;(99):1078-1084

36. 2006 Huang HM,Chiou HY,Chang JL. Activin A induces erythroid gene expressions and inhibits mitogenic cytokine-mediated K562 colony formation by activating p38 MAPK . J. Cell Biochem. .2006 ;(98):789-797

37. 2006 Chen CH,Hsu YH,Sue YM,Hou CC,Lee HM,Huang HM, Chen TH. Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptotransactivation in rat renal tubular cell NRK-52Er . Pflug. Arch. Eur. J. Phy. .2006 ;(452):16-24

38. 2005 Huang HM,Lin YL,Chen CH,Chang TW. Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells . J. Cell Biochem. .2005 ;(96):361-375

39. 2005 Juan SH,Yen JY,Lee HM,Huang HM. IL-5 inhibits apoptosis by up-regulation of c-myc expression in human hematopoietic cells . Ann. N.Y. Acad Sci. .2005 ;(1042):481-487

40. 2005 Huang HM,Liang YC,Cheng TH,Juan SH. Potential Mechanism of Blood Vessels Protection by Resveratrol, a Red Wine Component . Ann. N.Y. Acad Sci. .2005 ;(1042):349-356

41. 2004 Huang HM,Chang TW,Liu JC. Basic fibroblast growth factor antagonizes activin A-mediated growth inhibition and hemoglobin synthesis in K562 cells by activating ERK1/2 and deactivating p38 MAP kinase. . Biochem Biophys Res Commun. .2004 ;(320):1247-1252

42. 2000 Huang HM, Huang CJ, Jeffrey Yen JY. mcl-1 Is a Common Target of Stem Cell Factor and Interleukin 5 for the Apoptosis Prevention Activity via MEK/MAPK and PI-3K/Akt Pathways . Blood .2000 ;(96):1764-1771

43. 1999 Lee SF, Huang HM, Chao JR, Lin S, Yang-Yen HF ,Yen JY. Cytokine Receptor Common β Chain as a Potential Activator of Cytokine Withdrawal-Induced Apoptosis . Mol. Cell. Biol. .1999 ;(19):7399-7409

44. 1999 Huang HM, Li JC, Hsieh YC, Yang-Yen HF, Jeffrey Yen JY. Optimal Proliferation of a Hematopoietic Progenitor Cell Line Requires Either Costimulation With Stem Cell Factor or Increase of Receptor Expression That Can Be Replaced by Overexpression of Bcl-2 . Blood .1999 ;(93):2569-2577

45. 1998 Chao JR, Wang JM, Lee SF, Peng HW, Lin YH, Chou CH, Li JC, Huang HM, Chou CK, Kuo ML, Jeffrey Yen JY, Yang-Yen HF. mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response . Mol. Cell. Biol. .1998 ;(18):4883-4898


1. 1997 Jeffrey Yen JY, Yang-Yen SF, Huang HM, Hsieh YC, Lee SF, Chao JR, Lee JC. Molecular Mechanisms of Growth and Death Control of Hematopoietic Cells By Cytokines . Programmed Cell Death, edited by Shi et al. Plenum press, New York .1997

研究計畫

計畫名稱
108 IFI27在proinflammatory cytokines抑制紅血球分化的角色和作用機制
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
107 探討ETV1於抗藥性Bcr-Abl T315I慢性骨髓性白血病幹細胞的角色和作用機制
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
104 CD24於TNF-alpha抑制紅血球分化的角色及其訊號途徑機制
補助單位
科技部

計畫名稱
103 CD24在TNF-alpha抑制紅血球分化的角色
補助單位
科技部

計畫名稱
101 探討CD69在TNFalpha抑制紅血球分化中扮演的角色
補助單位
行政院國家科學委員會

計畫名稱
100 探討CD69在TNFalpha抑制紅血球分化中扮演的角色
補助單位
行政院國家科學委員會

計畫名稱
99 探討CD69在TNFalpha抑制紅血球分化中扮演的角色
補助單位
行政院國家科學委員會

計畫名稱
98 創新小分子藥物抗癌作用之分子機制研究
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
98 p38 isoforms於activin A誘導紅血球分化的角色探討
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
98 干擾素gamma對activin A誘導紅血球分化之抑制作用及作用機制
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
96 干擾素Alpha抑制血癌細胞生長之訊號傳遞機制
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
95 血球系統中倚賴IL-5 alpha受體之抗細胞凋亡功能之調控與作用機制
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
95 p38 MAP kinase調控細胞命運之分子機制 (二)
補助單位
行政院國家科學委員會

計畫名稱
94 重鬱症患者血清中BDNF及T淋巴球ERK磷酸化之相關研究
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
94 p38 MAP kinase調控細胞命運之分子機制
補助單位
行政院國家科學委員會

計畫名稱
93 細胞激素調控紅血球細胞分化之機制
補助單位
行政院國家科學委員會

計畫名稱
92 研究JAKs與IL-3/IL-5/GM-CSF受體結合之區域以及此區域對於受體專一性和細胞活性的相關影響
補助單位
行政院國家科學委員會

計畫名稱
91 協同活化的Janus Kinases於幹原母細胞中功能角色及訊號傳遞的探討
補助單位
行政院國家科學委員會

計畫名稱
90 同時活化的JAK1和 JAK2於細胞激素依賴型之幹原母細胞中功能角色的探討
補助單位
行政院國家科學委員會

計畫名稱
89 對第三介白質反應之幹原母細胞其JANUS激脢同時活化及其功能特性之研究
補助單位
行政院國家科學委員會