陳瑞明(Chen, Ruei-Ming)　教授

Email
rmchen@tmu.edu.tw
現   職
醫學科學研究所 教授

學經歷

學　歷

畢業學校與學位[修業時間]
國立臺灣大學毒理學研究所 博士
1993/09/01~1998/12/01
私立東吳大學環境科學系 學士
1986/09/01~1990/07/01

本校學術經歷

任職單位與職稱[起迄時間]
醫學科學研究所教授
2007/08/01~
醫學研究所教授
2006/08/01~2007/07/31
醫學研究所副教授
2004/02/01~2006/07/31
麻醉學科副教授
2003/02/01~2004/01/31
麻醉學科助理教授
1999/09/01~2003/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
細胞治療與再生醫學國際博士學位主任
2022/08/01 ~ 2023/07/31
醫學科學研究所所長
2018/09/01 ~ 2024/08/31
國際醫學研究碩士學位學程教授
2018/02/01 ~
國際醫學研究博士學位學程教授
2018/02/01 ~
國際醫學研究博士學位學程教授
2016/11/01 ~ 2017/10/31
國際醫學研究碩士學位學程教授
2016/11/01 ~ 2017/10/31
癌症生物學與藥物研發博士學位學程
2013/02/01 ~
生物資料庫管理中心(舊)主任
2012/04/01 ~ 2012/11/01
研究發展處副研發長
2012/03/01 ~ 2012/11/01
藥理學科教授
2009/09/01 ~

其它經歷

任職單位與職稱[起迄時間]
中台醫護技術學院兼任助理教授
1999/02/01~1999/07/31
台大醫學院博士後研究
1999/01/01~1999/07/31

專長與研究領域

學門領域
Brain research
Acute lung injury
Bone biology and bone diseases
Drug interactions
學術專長
Roles of microRNAs in brain tumors
Molecular mechanisms of endotoxin-induced surfactant protein expression
Roles of GATAs in acute lung injury
Therapy of brain tumors (honokiol and resveratrol)
Ketamine abuse and BBB damage
BBB in brain diseases (signal-transduction, translational study)
Pain control of osteoarthritis
Ketamine abuse and bladder dysfunction
Neuron protection by clinical drugs (dexmedetomidine, propofol, and resveratrol)
Signal-transducing events of osteoblast survival and death
Molecular regulation of osteoblast differentiation (osteogenesis)
Translational research in pathophysiologies of bone diseases
Tissue engineering of bone defects

論文著作

清冊下載

論文 Journal Paper


1. 2024 Hou YC,Chueh TY,Lu KC,Liu YC,Chen TH,Liu SH, Chen RM. The ratio of plasma beta-amyloid (1-42) over serum albumin can be a novel biomarker signature for diagnosing end-stage renal disease-associated cognitive impairment . Journal of Alzheimer's Disease .2024 ;(97):1393-1405

2. 2024 Circulating MicroRNAs as a biomarker signature of perinatal asphyxia . Pediatrics & Neonatology (in press) .2024

3. 2023 Resveratrol triggers the ER stress-mediated intrinsic apoptosis of neuroblastoma cells coupled with suppression of Rho-dependent migration and consequently prolongs mouse survival . Chemico-Biologucal Interactions .2023 ;(382):110645-11060

4. 2022 Aljabali AAA, Singh SK, Chellappan DK, Gupta G, Dua K, El-Tanani M, Tambuwala MM, Krishnan A.. Exosomal mediated signal transduction through artificial microRNA (amiRNA): a potential target for inhibition of SARS-CoV-2 . Cellular Signalling .2022 ;(95):110334-110345

5. 2022 Yang JD,Chen JT,Liu SH,Chen RM. Contribution of the testosterone-androgen receptor-PARD3B signaling axis to tumorigenesis and malignance of glioblastoma multiforme through stimulating cell proliferation and colony formation . Journal of Clinical Medicine .2022

6. 2022 Enzalutamide induces apoptotic insults to human drug-resistant and -sensitive glioblastoma cells via an intrinsic bax-mitochondrion-cytochrome c caspase cascade activation pathway . Molecules .2022 ;(27):6666-6683

7. 2021 Wu GJ,Cherng YG,Chen JT,Chang CC,Liu SH,Chen RM. Genistein triggers translocation of estrogen receptor-alpha in mitochondria to induce expressions of ATP synthesis-associated genes and consequently improves energy production and osteoblast maturation . American Journal of Chinese Medicine .2021 ;(49):901-923

8. 2021 Lee YW,Cherng YG,Yang ST,Liu SH,Chen TL,Chen RM. Hypoxia induced by cobalt chloride triggers autophagic apoptosis of human and mouse drug-resistant glioblastoma cells through targeting the PI3K-Akt-mTOR signaling pathway . Oxidative Medicine and Cellular Longevity .2021 ;(2021):5558618-5558633

9. 2021 Hou YC,Lu CL,Cheng CM,Huang CL,Lin YF,Lu KC, Chung YL, Chen RM. The role of plasma neurofilament light protein for assessing cognitive impairment in patients with end-stage renal disease . Frontiers Aging Neuroscience .2021 ;(13):657794-657806

10. 2021 Yang WB,Wu AC,Hsu TI,Liou JP,Lo WL,Chang KY, Chen PY, Kikkawa U, Yang ST, Kao TZ, Chen RM, Chang WC, Ko CY, Chuang JY. Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells . Cell Death & Disease .2021 ;(12):884-896

11. 2021 Wu GJ,Chen KY,Yang JD,Liu SH,Chen RM. Naringin improves osteoblast mineralization and bone healing and strength through estrogen receptor alpha-dependent regulation of alkaline phosphatase gene expression . Journal of Agricultural and Food Chemistry .2021 ;(69):13020-1033

12. 2020 Renal insufficiency plays a crucial association factor in severe knee osteoarthritis-induced pain in patients with total knee replacement: a retrospective study . Medicine .2020 ;(99):e19125

13. 2020 Gong-Jhe Wu,Sun-Ta Yang,Ruei-Ming Chen. Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells . Molecules .2020 ;(25):1450

14. 2020 Lai YH,Huang YC,Huang LT,Chen RM,Chen CF. Cervical noninvasive vagus nerve stimulation for migraine and cluster headache: a systematic review . Neuromodulation .2020 ;(23):721-731

15. 2020 Sun DP,Lee YW,Chen JT,Lin YW,Chen RM. The bradykinin-BDKRB1 axis regulates aquaporin 4 gene expression and consequential migration and invasion of malignant glioblastoma cells via a Ca2+-MEK1-ERK1/2-NF-κB Mechanism . Cancers .2020 ;(12):667-686

16. 2020 Tc-99m TRODAT-1 SPECT is a potential biomarker for restless leg . Journal of Clinical Medicine 2020 .2020

17. 2020 Role of vitamin D in modulating mesenchymal stem cells and endothelial progenitor cells for vascular calcification . International Journal of Molecular Sciences .2020 ;(21):2466

18. 2020 Cervical non-invasive vagus nerve stimulation effectively relieves pain in migraine sufferers . NeuroNews .2020

19. 2020 Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma . Neuro-Oncology .2020

20. 2020 Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism . Molecules .2020 ;(25):2876-2892

21. 2020 Inhibition of estrogen receptor alpha signaling delays bone regeneration and alters osteoblast maturation, energy metabolism, and angiogenesis . Life Sciences .2020 ;(258):118195

22. 2020 Genistein improves bone healing via triggering estrogen receptor alpha-mediated expression of osteogenesis-associated genes and consequent maturation of osteoblasts . Journal of Agricultural and Food Chemistry .2020 ;(68):10639-10650

23. 2020 Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53 . International Journal of Biological Sciences .2020 ;(16):3184-3199

24. 2019 Hou YC,Lu CL,Zheng CM,Chen RM ,Lin YF ,Liu WC, Yen TH, Chen R, Lu KC. Emerging role of vitamins D and K in modulating uremic vascular calcification: The aspect of passive calcification . Nutrients .2019 ;(11):152

25. 2019 Lin MC,Lee YW,Tseng YY,Lin YW,Chen JT,Liu SH, Chen RM. Honokiol Induces autophagic apoptosis in neuroblastoma cells through a P53-dependent pathway . American Journal of Chinese Medicine .2019 ;(47):859-912

26. 2019 Yeh PS,Lee YW,Chang WH,Wang W,Wang JL,Liu SH, Chen RM. Biomechanical and tomographic differences in the microarchitecture and strength of trabecular and cortical bone in the early stage of male osteoporosis . Plos One .2019

27. 2018 Chio CC,Chen KY,Chuang JY,Liu CC,Liu SH,Chen RM. Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells . BMC Cancer .2018 ;(18):379

28. 2018 Wu GJ,Lin YW,Chuang CY,Tsai HC,Chen RM. Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF-κB-mediated iNOS and IL-6 gene expressions . Life Sciences .2018 ;(195):25-32

29. 2018 Yang JD,Liu SH,Liao MH,Chen RM,Liu PY,Ueng TH. Effects of tebuconazole on cytochrome p450 enzymes, oxidative stress, and endocrine disruption in male rats . Environmental Toxicology .2018

30. 2018 Chen JT,Wei L,Chen TL,Huang CJ,Chen RM. Regulation of cytochrome P450 gene expression by ketamine: a review . Expert Opinion on Drug Metabolism and Toxicology .2018 ;(14):709-720

31. 2018 Chio CC,Tai YT,Mohanraj M,Liu SH,Yang ST,Chen RM. Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway . Phytomedicine .2018 ;(49):41-51

32. 2018 Wu GJ,Lin YW,Tsai HC,Lee YW,Chen JT,Chen RM. Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions . Life Sciences .2018 ;(213):279-286

33. 2017 Cheng BC,Chen JT,Yang ST,Chio CC,Liu SH,Chen RM. Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway . International Journal of Oncology .2017 ;(50):964-974

34. 2017 Wu GJ,Chen JT,Tsai HC,Chen TL,Liu SH,Chen RM. Protection of dexmedetomidine against ischemia/reperfusion-induced apoptotic insults to neuronal cells occurs via an intrinsic mitochondria-dependent pathway . Journal of Cellular Biochemistry .2017 ;(118):2635-2644

35. 2017 Chuang JY,Lo WL,Ko CY,Chou SY,Chen RM,Chang KY, Hung JJ, Su WC, Chang WC*, Hsu TI. Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide rResistance through DHEA-mediated protection in glioma . Oncogenesis .2017 ;(6):e399

36. 2017 Tsai HC,Chen TL,Chen YP,Chen RM. Traumatic osteoarthritis induced persistent mechanical hyperalgesia in a rat model of anterior cruciate ligament transection plus a medial meniscetomy . Journal of Pain Research .2017 ;(11):41-50

37. 2017 Liao MH,Lin PI,Ho WP,Chan WP,Chen TL,Chen RM. Participation of GATA-3 in regulation of bone healing through transcriptionally upregulating bcl-xL gene expression . Experimental & Molecular Medicine .2017 ;(49):e398-e410

38. 2017 Lin PI,Tai YT,Chan WP,Lin YL,Liao MS,Chen RM. Estrogen/ERα signaling axis participates in osteoblast maturation via upregulating chromosomal and mitochondrial complex gene expressions . Oncotarget .2017 ;(9):1169-1186

39. 2016 Chang CY,Lui TN,Lin JW,Lin YL,Hsing CH,Wang JJ, Chen RM. Roles of microRNA-1 in hypoxia-induced apoptotic insults to neural cells . Archives of Toxicology .2016 ;(90):191-202

40. 2016 Wu GJ,Wang W,Lin YL,Liu SH,Chen RM. Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-XL gene expression and protein translocation . Archives of Toxicology .2016 ;(90):905-916

41. 2016 Chung-Ching Chio,Li Wei,Tyng Guey Chen,Chien-Min Lin,Ja-Ping Shieh,Poh-Shiow Yeh, Ruei-Ming Chen. Neuron-derived orphan receptor 1 transduces survival signals in neuronal cells in response to hypoxia-induced apoptotic insults . Journal of Neurosurgery .2016 ;(124):1654-1664

42. 2016 Chen JT,Chen TG,Chang YC,Chen CY,Chen RM. Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier . Toxicology .2016 ;(339):40-50

43. 2016 Lin CJ,Chang YA,Lin YL,Liu SH,Chang CK,Chen RM. Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis . Phytomedicine .2016 ;(23):517-527

44. 2016 Huang JS,Yao CJ,Chuang SE,Yeh CT,Lee LM,Chen RM, Chao WJ, Whang-Peng J, Lai GM. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/ STAT signaling pathway suppression and apoptosis induction . BMC Cancer .2016 ;(16):245

45. 2016 Lin CJ,Chen TL,Tseng YY,Wu GJ,Hsieh MH,Lin JW, Chen RM. Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway . Toxicology And Applied Pharmacology .2016 ;(304):59-69

46. 2016 Wu GJ,Lin CJ,Lin JW,Chen RM. Analyses of honokiol-induced autophagy of human glioma cells in vitro and in vivo . Data in Brief .2016 ;(206):667-672

47. 2016 Lin CJ,Lin YL,Luh F,Yen Y,Chen RM. Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis . Oncotarget .2016 ;(7):42408-42421

48. 2016 Chen JT,Lin YL,Chen TL,Tai YT,Chen CY,Chen RM. Ketamine alleviates bradykinin-induced disruption of the mouse cerebrovascular endothelial cell-constructed tight junction barrier via a calcium-mediated redistribution of occludin polymerization . Toxicology .2016 ;(368):142-151

49. 2016 Yeh PS,Wang W,Chang YA,Lin CJ,Wang JJ,Chen RM. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration . Cancer Letters .2016 ;(370):66-77

50. 2015 Li CH,Shyu MK,Jhan C,Cheng YW,Tsai CH,Liu CW, Lee CC, Chen RM, Kang JJ. Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice . Toxicological Sciences .2015 ;(148):192-203

51. 2015 Ho MH,Yao CJ,Liao MH,Lin PI,Liu SH,Chen RM. Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway . International Journal of Nanomedicin .2015 ;(10):5941-5954

52. 2015 Lee YE,Hong CY,Lin YL,Chen RM. MicroRNA-1 participates in nitric oxide-induced apoptotic insults to MC3T3-E1 cells by targeting heat-shock protein-70 . International Journal of Biological Sciences .2015 ;(11):246-255

53. 2015 Fang HW,Tai YT,Kao WY,Lin PI,Chang GW,Hung YJ, Chen RM. Effects of polypropylene carbonate/poly(D,L-lactic) acid/tricalcium phosphate elastic composites on improving osteoblast maturation . Annals of Biomedical Engineering .2015 ;(43):1999-2009

54. 2014 Tai YT,Lin YL,Chang CC,Cherng YG,Don MJ,Chen RM. Ring-oxidative biotransformation and drug interactions of propofol in the livers of rats . Biomedical Research International (Regular article) 2015: Article ID 658928 .2014

55. 2014 Lee YE,Liu HC,Lin YL,Liu SH,Liao MS,Yang RS, Chen RM. Drynaria fortunei J. Sm. improves the bone mass of ovariectomized rats through osteocalcin-involved endochondral ossification . Journal of Ethnopharmacology .2014 ;(158):94-101

56. 2014 Liao MH,Tai YT,Cherng YG,Liu SH,Chang YA,Lin PI, Chen RM. Genistein induces estrogen receptor-α gene expression in osteoblasts through activation of MAPKs/NF-κB/AP-1 and promotes cell mineralization . British Journal of Nutrition .2014 ;(111):55-63

57. 2014 Chang HC,Tai YT,Cherng YG,Lin JW,Liu SH,Chen TL, Chen RM. Resveratrol attenuates high-fat diet-induced disruption of the blood−brain barrier and protects brain neurons from apoptotic insults . Journal of Agriculture and Food Chemistry .2014 ;(62):3466-3475

58. 2014 Ho MH,Liao MH,Lin YL,Lai CH,Lin PI,Chen RM. Improving effects of chitosan nanofiber scaffolds on osteoblast proliferation and maturation . International Journal of Nanomedicine .2014 ;(9):4293-4304

59. 2013 Liu FL,Chen TL,Chen RM. Mechanisms of ketamine-induced immunosuppression . Acta Anaesthesiologica Taiwanica .2013 ;(50):172-177

60. 2013 Chen RM,Tai YT,Chen TG,Lin TH,Chang HC,Chen TL, Wu GJ. Propofol protects against nitrosative stress-induced apoptotic insults to cerebrovascular endothelial cells via an intrinsic mitochondrial mechanism . Surgery .2013 ;(154):56-68

61. 2013 Lu CC,Tsai CS,Hu OYP,Chen RM,Chen TL,Ho ST, Gan TJ. Pharmacokinetics of desflurane elimination from respiratory gas and blood during the 20 minutes after cardiac surgery . Journal of the Formosan Medical Association .2013 ;(112):185-192

62. 2013 Wu TT,Tai YT,Cherng YG,Chen TG,Chen TL,Chang HC, Chen RM. GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism . Plos One 2013; 8(8): e72404 .2013 ;(8)

63. 2013 Lu CC,Lin TC,Hsu CH,Yu MH,Ku CH,Chen TL, Chen RM, Ho ST. Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. . J Anesth .2013 ;(27):35-42

64. 2013 Chiu CC,Lin JW,Cheng HA,Chiu WT,Wang YH,Wang JJ, Hsing CH, Chen RM. MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells . Archives of Toxicology .2013 ;(87):458-468

65. 2012 Lu CC,Lin TC,Hsu CH,Yu MH,Chen TL,Chen RM, Ku CH, Ho ST. Hyperventilation accelerates the rise of arterial blood concentrations of desflurane in gynecologic patients. . Clinics (Sao Paulo) .2012 ;(67):1029-1034

66. 2012 Lu CC,Li MH,Lin TC,Chen TL,Chen RM,Tung CS, Tseng CJ, Ho ST. Water ingestion reduces skin blood flow through sympathetic vasoconstriction. . Clin Auton Res .2012 ;(22):63-69

67. 2012 Lin JW,Chen JT,Hong CY,Lin YL,Wang KT,Yao CJ, Lai GM, Chen RM. Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic Bax-mitochondrion-cytochrome c-caspase protease pathway . Neuro-Oncology .2012 ;(14):302-314

68. 2012 Wei JD,Lin YL,Tsai CH,Shieh HS,Lin PI,Ho WP, Chen RM. SATB2 participates in regulation of menadione-induced apoptotic insults to osteoblasts . Journal of Orthopaedic Research .2012 ;(30):1058-1066

69. 2012 Liu FL,Chuang CY,Tai YT,Tang HL,Chen TG,Chen TL, Chen RM. Lipoteichoic acid induces surfactant protein-A biosynthesis in human alveolar type II epithelial cells through activating the MEK1/2-ERK1/2-NF-κB pathway . Respiratory Research .2012 ;(13):88

70. 2011 Chuang CY,Chen TL,Cherng YG,Tai YT,Chen TG,Chen RM. Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway. . Archives of Toxicology .2011 ;(85):209-218

71. 2011 Lin YL,Chang HC,Chen TL,Chang JH,Chiu WT,Lin JW, Chen RM. Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells . Journal of Nutrition .2011 ;(140):2187-2192

72. 2011 Chang HC,Chen TG,Tai YT,Chen TL,Chiu WT,Chen RM. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells . Journal of Cerebral Blood Flow and Metabolism .2011 ;(31):842-854

73. 2011 Chuang CY,Chen TG,Tai YT,Chen TL,Lin YH,Tsai CH, Chen RM. Toll-like receptor 2-mediated sequential activation of MyD88 and MAPKs contributes to lipopolysaccharide-induced sp-a gene expression in human alveolar epithelial cells . Immunobiology .2011 ;(216):707-714

74. 2011 Wu TT,Chen TL,Loon WS,Tai YT,Cherng YG,Chen RM. Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-κB . Cytokine .2011 ;(55):40-47

75. 2011 Hsu CK,Liao MH,Tai YT,Liu SH,Ou KL,Fang HW, Lee IJ, Chen RM. Nanoparticles prepared from the water extract of Gusuibu (Drynaria fortunei J. Sm.) protects osteoblasts against insults and promotes cell maturation . International Journal of Nanomedicine .2011 ;(6):1405-1413

76. 2011 Ueng YF,Chen CC,Chung YT,Liu TY,Chang YP,Lo WS, Murayama N, Yamazaki H, Soucˇek P, Chau GY, Chi CW, Chen RM, Li DT. Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo . British Journal of Pharmacology .2011 ;(263):1250-1262

77. 2010 Chen JT,Chen RM. Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression . Expert Opinion On Drug Metabolism and Toxicology .2010 ;(6):273-281

78. 2010 Chen TL,Wu GJ,Hsu CS,Fong TH,Chen RM. Nitrosative stress induces osteoblast apoptosis through downregulating MAPK-mediated NFκB/AP-1 activation and subsequent Bcl-XL expression . Chemico-Biological Interactions .2010 ;(184):359-365

79. 2010 Chen RM,Lin YL,Chou CW. GATA-3 transduces survival signals in osteoblasts through upregulation of bcl-xL gene expression. . Journal of Bone and Mineral Research .2010 ;(25):2193-2204

80. 2010 Hung TY,Chen TL,Liao MH,Ho WP,Liu DZ,Chuang WC, Chen RM. Drynaria fortunei J. Sm. promotes osteoblast maturation by inducing differentiation-related gene expression and protecting against oxidative stress-induced apoptotic insults . Journal of Ethnopharmacology .2010 ;(131):70-77

81. 2010 Lee CJ,Tai YT,Lin YL,Chen RM. Molecular mechanisms of propofol-involved suppression of nitric oxide biosynthesis and inducible nitric oxide synthase gene expression in lipopolysaccharide-stimulated macrophage-like Raw 264.7 cells . Shock .2010 ;(33):93-100

82. 2010 Chang HC,Lin KH,Tai YT,Chen JT,Chen RM. Lipoteichoic acid-induced TNF-α and IL-6 gene expressions and oxidative stress production in macrophages are suppressed by ketamine through downregulating toll-like receptor 2-mediated activation of ERK1/2 and NFκB . Shock .2010 ;(33):485-492

83. 2009 Ho WP,Chan WP,Hsieh MS,Chen RM. Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis . Journal of Cellular Biochemistry .2009 ;(108):1084-1093

84. 2009 Chuang CY,Chen TL,Chen RM. Molecular mechanisms of lipopolysaccharide-caused induction of surfactant protein-A gene expression in human alveolar epithelial A549 cells . Toxicology Letters .2009 ;(191):132-139

85. 2009 Wu TT,Chen TL,Chen RM. Lipopolysaccharide triggers macrophage activation of inflammatory cytokine expression, chemotaxis, phagocytosis, and oxidative ability via a toll-like receptor 4-dependent pathway: validated by RNA interference . Toxicology Letters .2009 ;(191):195-202

86. 2009 Yang RS,Tzeng HP,Ho FM,Chuang CC,Chen BL,Huang CF, Chen YW, Chen RM, Liu SH.. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. . Acta Biomaterialia .2009 ;(5):3258-3264

87. 2009 Wu GJ,Chen TL,Chang CC,Chen RM. Propofol suppresses tumor necrosis factor-α biosynthesis in lipopolysaccharide-stimulated macrophages possibly through downregulation of nuclear factor-kappa B-mediated toll-like receptor 4 gene expression. . Chem-Biol Interact .2009 ;(180):465-471

88. 2009 Chen TL,Chang CC,Lin YL,Ueng YF,Chen RM. Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1β gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells . Toxicology and Applied Pharmacology .2009 ;(240):15-25

89. 2009 Chiu WT,Lin YL,Chou CW,Chen RM. Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFκB. . Chem-Biol Interact .2009 ;(181):430-439

90. 2009 Chang HC,Chen TL,Chen RM. Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function . Drug Metabolism and Distribution .2009 ;(37):24-31

91. 2009 Lee ST,Wu TT,Yu PY,Chen RM. Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway . British Journal of Anaesthesia .2009 ;(102):80-89

92. 2009 Pan WC,Chen RM,Shen YC,Chen CC,Ueng YF. Suppressive effect of tobacco smoke extracts on oral P-glycoprotein function and its impact in smoke-induced insult to oral epidermal cells . Toxicology Letters .2009 ;(185):116-123

93. 2009 Chen KL,Wang SS,Yang YY,Yuan RY,Chen RM,Hu CJ. The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells . Biochem Biophys Res Commun .2009 ;(378):57-61

94. 2008 Cherng YG,Chang HC,Lin YL,Kuo ML,Chiu WT,Chen RM. Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-mitochondria . Journal of Orthopedic Research .2008 ;(26):1018-1026

95. 2008 Wu GJ,Chen TL,Ueng UF,Chen RM. Ketamine inhibits tumor necrosis factor-α and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-jun N-terminal kinase phosphorylation and activator protein-1 activation . Toxicology and Applied Pharmacology .2008 ;(228):105-113

96. 2008 Lu CC,Tsai CS,Hu OY,Chen RM,Chen TL,Ho ST. Pharmacokinetics of isoflurane in human blood . Pharmacology .2008 ;(81):344-349

97. 2008 Lu CC,Ho ST,Liaw WJ,Chen RM,Chen TL,Lin CY. The effect of heat-moisture exchanger and closed-circuit technique on airway climate during desflurane anesthesia . Journal of Anesthesia .2008 ;(22):7-12

98. 2007 Chen TG,Chen TL,Tai YT,Cherng YG,,Chang YT,Chen RM. Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a bax-mitochondria-caspase protease pathway. . Toxicol Appl Pharmacol .2007 ;(219):42-53

99. 2007 Tai YT,Chen TL,Cherng YG,Chang CC,Chen JT,Chen RM. Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. . J Orthop Res .2007 ;(25):625-635

100. 2007 Wu GJ,Chen TG,Chen TL,Chang HC,Chiu WT,Chen RM. Nitric oxide from both exogenous and endogenous sources activates mitochondria-dependent events and induces insults to human chondrocytes. . J Cell Biochem .2007 ;(101):1520-1531

101. 2006 Chang CC,Liao YS,Lin YL,Chen RM. Nitric Oxide Protects Osteoblasts from Oxidative Stress-Induced Apoptotic Insults via a Mitochondria-Dependent Mechanism . Journal of Orthopaedic Research .2006 ;(24):1917-1925

102. 2006 Chan WH,Chen TL,Chen RM,Sun WZ,Ueng TH. Propofol metabolism is enhanced after repetitive ketamine administration in rats: the role of cytochrome P-450 2B induction . British Journal of Anaesthesia .2006 ;(97):351-358

103. 2005 Chen RM,Chen TL,Lin YL,Chen TG,Tai YT. Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells through downregulating endothelial nitric oxide synthase expression and intracellular calcium levels. . Critical Care Medicine .2005 ;(33):1044-1049

104. 2005 Chen RM,Chen TL,Chiu WT,Chang CC. Molecular mechanism of nitric oxide-induced osteoblast apoptosis. . Journal of Orthopaedic Research .2005 ;(23):462-468

105. 2005 Chang Y,Chen TL,Sheu JR,Chen RM. Suppressive effects of ketamine on macrophage functions . Toxicology and Applied Pharmacology .2005 ;(204):27-35

106. 2005 Chen RM,Chen TG,Chen TL,Lin LL,Chang CC,,Chang HC,Wu CH. Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages. . Annals of the New York Academy of Sciences .2005 ;(1042):262-271

107. 2005 Chen RM,Wu GJ,Chang HC,Chen JT,Chen TF,Lin YL, Chen TL. 2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation. . Annals of the New York Academy of Sciences .2005 ;(1042):448-459

108. 2005 Ho WP,Chen TL,Chiu WT,Tai YT,Chen RM. Nitric oxide induced osteoblast apoptosis through a mitochondrial-dependent pathway. . Annals of the New York Academy of Sciences .2005 ;(1042):460-470

109. 2005 Wu GJ,Tai YT,Chen TL,Lin LL,Ueng YF,Chen RM. Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophages. . Annals of the New York Academy of Sciences .2005 ;(1042):168-176

110. 2004 Chen JT,Chen RM,Lin YL,Chang HC,Lin YH,Chen TL, Chen TG. Confocal laser scanning microscopy: I. an overview of principle and practice in biomedical research. . Acta Anaesthesiol Sin .2004

111. 2004 Ueng YF,Chen RM. The role of cytochrome P450 in herb-drug interactions. . Current pharmacogenetics .2004 ;(2):83-112

112. 2004 Ueng YF,Tsai TH,Don MJ,Chen RM,Chen TL. Alternation of the pharmacokinetics of theophyline by rutaecarpine, an alkaloid of the medical herb Evodia rutaecarpa, in rats. . Journal of Pharmacy & Pharmacology .2004 ;(57):227-232

113. 2003 Wu CH, Chen TL, Chen TG, Ho WP, Chiu WT, and Chen RM (Corresponding author). Nitric oxide modulates pro- and anti-inflammatory cytokines in lipopolysaccharide-activated macrophages. . J Trauma .2003 ;(55):540-545

114. 2003 Chen RM, Wu CH, Chang HC, Lin YL, Sheu JR and Chen TL. Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels . Anesthesiology .2003 ;(98):1178-1185

115. 2003 Chen RM, Wu GJ, Tai YT, Sun WZ, Lin YL, Jean WC and Chen TL. Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase . Archives of Toxicology .2003 ;(77):418-423

116. 2002 Chuang H, Tsai SY, Chen TL and RM Chen (Corresponding author). Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosis. . Can J Anesth .2002 ;(49):477-480

117. 2002 Chen RM, Lin YL, Jean WC, Chen JS, Wang JH and Liu HC. Nitric oxide induces osteoblast apoptosis through de novol synthesis of Bax protein . J Ortho Res .2002 ;(20):295-302

118. 2001 Chang HC, Tsai SY, Wu GJ, Lin YH, Chen RM and Chen TL. Effects of propofol on mitochondrial function and intracellular cacium shift in bovine aortic endothelial model. . Acta Anaesthesiol Sin .2001 ;(39):115-122

119. 2001 Lin JH, Lin YT, Huang YJ, Wen KC, Chen RM, Ueng TH and Liao CH. Isolation and cytotoxicity of flavonoids from Daphnis Genkwae Flos . J Food Drug Anal .2001 ;(9):6-11

120. 2001 Liu HC, Chen RM (corresponding author), Jean WC and Lin YL. Cytotoxic and Antioxidant Effects of the Water Extract of Traditional Chinese Herb Gusuibu (Drynaria fortunei) on rat osteoblasts . J Formos Med Assoc .2001 ;(100):383-388

121. 2000 Chen RM, Chou MW and Ueng TH. Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene . Toxicology Letter .2000 ;(117):69-77

122. 2000 Chen TL, Chang HC, Chen TG, Tai YT, Chen RM. Modulation of cytochrome P450-dependent monooxygenases in streptozotocin-unduced diabetic hamster: I. Effects of propofol on defluorination and cytochrome P-450 activities. . Acta Anaesthesiol. Sin. .2000 ;(38):15-21

123. 2000 Chen TG, Tai YT, Chang HC, Hong CT, Chen RM, Chen TL. Modulation of cytochrome P450-dependent monooxygenases in streptozotocin-unduced diabetic hamster: II. Reverse role of insulin to P450’s activities and defluorination. Acta Anaesthesiol. . Acta Anaesthesiol. .2000 ;(38):65-72

124. 2000 Chen TL, Chen TG, Tai YT, Chang HC, Chen RM, Lin CJ, Ueng TH. Protective role of propofol in nephrotoxicity of volatile anaesthetics ? –in vitro inhibition to renal cytochrome P450’s activities and enflurane defluorination. . Can. J. Anaesth. .2000 ;(47):680-686

125. 2000 Ueng TH, Hu SH, Chen RM, Wan HW and Kuo ML. Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells and lung carcinoma NCI-H322 cells by motorcycle exhaust particulate . J. Toxicol. Environ. Health .2000 ;(54):509-527

126. 2000 Tai YT, Wu CC, Wu GJ, Chang HC, Chen TG, Chen RM and Chen TL.. Study of propofol in bovine aortic endothelium: I. Inhibitory effect on bradykinin-induced intracellular calcium immobilization . Acta Anaesthesiologica Sinica. .2000 ;(38):181-186

127. 1999 Liu HC, Chen RM, Lin, FH, Fang HW. Sintered beta-dicalcium phosphate particles induce intracellular reactive oxygen species in rat osteoblasts . Biomed. Eng. Appl. Basis Comm. .1999 ;(11):259-264

128. 1998 Chen RM, Chou, MW, Ueng TH. Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene . Arch. Toxicol. 72 (7), 395-401. .1998 ;(72):395-401

129. 1997 Ueng TH, Hwang WP, Chen RM, Wang, HW, Kuo ML. Effects of motorcycle exhaust on cytochrome P450-dependent monooxygenase and glutathione S-transferase in rat tissues . J. Toxicol. Environ. Health 54 (7), 509-527 .1997 ;(54):509-527

130. 1997 Chen RM, Ueng TH. Induction of cytochrome P450 1A, 2B and 2E in hamster tissues by acetone . Arch. Toxicol. .1997 ;(71):489-495

會議論文 Conference Paper


1. 2006 Chen RM,Lin YL,Chang CC. Nitric oxide induces apoptotic insults of human chondrocytes via a mitochondria-dependent mechanism. . The 52nd Annual Meeting of Orthopaedic Research Society, Chicago, IL, USA. .2006

2. 2005 Chen RM,Chen TL,Lin YL. Protective effects of propofol on oxidative stress-induced osteoblast insults. . The 51th Annual Meeting of Orthopaedic Research Society, Washington, D.C., USA .2005

3. 2004 Chen RM,Ho WP,Chang CC,Huang JY,Lin YL,Chen TL. Nitric oxide-induced osteoblast apoptosis is involved by the mitochondria-dependent caspase activation. . The 50th Annual Meeting of Orthopaedic Research Society, San Francisco, Ca, USA. .2004

4. 2004 Chen RM,Chen TL,Liao CY. Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells through downregulating endothelial nitric oxide synthase expression and intracellular calcium levels . The Nineteenth Joint Annual Conference of Biomedical Science, Taipei, Taiwan .2004

5. 2004 Chen RM,Chen TL,Lin LL,Chang CC,Chang HC,Wu CH. Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages . The 2nd Conference of Asian Society for Mitochondrial Research and Medicine. Taipei, Taiwan .2004

6. 2004 Chen RM,Chen TL,Tai YT,Lin LL. Propofol specifically inhibits mitochondrial membrane potential but not complex I nadh dehydrogenase activity thus reducing cellular atp biosynthesis and migration of macrophages. . The 2nd Conference of Asian Society for Mitochondrial Research and Medicine. Taipei, Taiwan. .2004

7. 2004 Chen RM,Ho WP,Chen TL,Chiu WT,Tai YT. Nitric oxide induced osteoblast apoptosis through a mitochondrial-dependent pathway. . The 2nd Conference of Asian Society for Mitochondrial Research and Medicine. Taipei, Taiwan. .2004

8. 2004 Chen RM,Chen TL,Chang HC,Chen JT,Chen TF,Lin YL. 2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation. . The 2nd Conference of Asian Society for Mitochondrial Research and Medicine. Taipei, Taiwan. .2004

9. 2004 Chen JT,Chen TL,Chen RM. Effects of intravenous anesthetic agents on endothelin-1 and cox-1 expression in human umbilical vein endothelial cells. . The Nineteenth Joint Annual Conference of Biomedical Science, Taipei, Taiwan. .2004

10. 2004 Wang HC,Chen TF,Chen TL,Chen RM. Regulatory effects of 2,6-diisopropylphenol on the cytoskeleton of hepatocytes, macrophages and endothelial cells . The Nineteenth Joint Annual Conference of Biomedical Science, Taipei, Taiwan. .2004

11. 2004 Lin YL,Chen TL,Chen RM. CYP2B1/2 contributes to propofol metabolism to 4-hydroxy-propofol in rat liver. . The Nineteenth Joint Annual Conference of Biomedical Science, Taipei, Taiwan. .2004

12. 2004 Chen RM,Chen TL,Chiu WT,Lin YL. Biphasic effects of nitric oxide on chondrocyte activities. . The 5th combined meeting of ORS, USA, Canada, Europe, and Japan. Banff, Alberta, Canada. .2004

13. 2003 Chen RM, Liu HC, Ho WP, Lin YL, Liao YS, Huang JY, and Chen TL. Nitric oxide induced osteoblast apoptosis is involved by the modulation of intracellular calcium concentrations and caspase-3 activity. . The 49th Annual Meeting of Orthopaedic Research Society, New Orlean, Miss, USA. .2003

14. 2003 Chen RM, Liu HC, Jean WC, Lin YL, Lin YW, and Chen TL. Cytochrome c is involved in no-induced osteoblast apoptosis. . The 49th Annual Meeting of Orthopaedic Research Society, New Orlean, Miss, USA. .2003

15. 2003 Chen RM, Chang HC, Chen TG, Tai YT, Chen TL. Supressive effects of propofol on macrophage functions . The Eighteenth Joint Annual Conference of Biomedical Science. .2003

16. 2003 Lin YL, Huang JY, Liao CY and Chen RM. Modulation of intracellular calcium, cytochrome c and caspase-3 contributes to nitric oxide-induced osteoblast apoptosis . The Eighteenth Joint Annual Conference of Biomedical Science. .2003

17. 2002 Chen RM, Chiu WT, Chen TL, Chen SY, Lin JW and Chiang PY. 中華民國外科醫學會第六十一次學術演講大會 . EXPRESSION OF THE PROTO-ONCOGENE c-jun IN HUMAN MENINGIOMAS .2002

18. 2002 Wu CH, Chen RM, Chen TL and Chiu WT. Modulating effects of nitric oxide on endotoxin lipopolysaccharide-induced tnf-, il-1 and il-10 in macrophages. . 中華民國外科醫學會第六十一次學術演講大會 .2002

19. 2002 Chen RM, Chen TL, Lin YL, Ho WP, and Liao YS. Role of cytochrome c in nitric oxide-induced osteoblast apoptosis. . The Seventeenth Joint Annual Conference of Biomedical Science. Poster 407. .2002

20. 2002 20. Chen RM, Lin YL, Chen TG, Tai YT, Chang HC and Chen TL. Propofol protects macrophages from nitric oxide–induced apoptosis. . The Seventeenth Joint Annual Conference of Biomedical Science. Poster 420. .2002

21. 2002 Chen RM, Ho WP, Liao YS, Lin YH, Lin YL and Chen TL. Nitric oxide induced osteoblast apoptosis is involved by cellular oxidative stress, mitochondrial membrane potential and bcl-2 protein. . 91年中華民國骨科醫學會學術研討會 .2002

22. 2002 Chen RM, Chen JT, Chang HC, Chen TG, Tai YT, and Chen TL. Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. . 91年中華民國麻醉醫學會會員大會暨第四十六屆學術研討會 .2002

23. 2001 Chen RM, Liu HC, Lin YL and Jean WC. Modulations of intracellular oxidative stress, mitochondrial membrane potential and Bcl-2/Bax proteins are involved in NO-induced osteoblast apoptosis . The 47th Annual Meeting of Orthopaedic Research Society, San Francisco, California, USA. .2001

24. 2001 Chen RM, Liu HC, Ho WP and Chen TL. Nitric oxide protects human osteoblast-like MG63 cells from oxidative stress-induced cell apoptosis through suppression of Bax protein. . The 47th Annual Meeting of Orthopaedic Research Society, San Francisco, California, USA. .2001

25. 2001 Chen RM, Liu HC, Wu CH and Jean WC. Nitric oxide induces osteoblast apoptosis through the de novo synthesis of bax protein. . The Sixteenth Joint Annual Conference of Biomedical Science. Poster 331. .2001 ;(16)

26. 2001 Chen RM, Ho WP and Chen TL. Protective effects of nitric oxide on oxidative stress-induced cell apoptosis. . The Sixteenth Joint Annual Conference of Biomedical Science. Poster 332. .2001 ;(16)

27. 2001 Chen RM, Wu CH, Lin YL and Chen TL. Protective role of propofol to cellular damages induced by nitric oxide. . The Sixteenth Joint Annual Conference of Biomedical Science. Poster 333. .2001 ;(16)

28. 2001 Chen RM, Wu CH and Chen TL. Effects of nitric oxide on modulating productions of pre- and anti-inflammatory cytokines. . 中華民國外科醫學會第六十次學術演講大會. .2001

29. 2001 Chen RM and Liu HC. Induction of intracellular reactive oxygen species in rat osteoblasts exposed to sintered beta-dicalcium phosphate particles. . Fourth Combined Meeting of the Orthopaedic Research Societies of the USA, Canada, Europe and Japan .2001

30. 2001 Liu HC and Chen RM. 傳統骨科中藥材骨碎補臨床療效研究 . 行政院衛生署中醫藥委員會中醫藥研究成果發表會 2001, 國防醫學院, 台北, 中華民國 .2001

31. 2000 Chen RM and Liu HC. Nitric oxide induced apoptosis of rat osteoblast through induction of Bax protein. . The 46th Annual Meeting of Orthopaedic Research Society, Orlando, Florida, USA. .2000

32. 2000 Liu HC and Chen RM. 傳統骨科中藥材骨碎補對骨細胞之生理活性研究 . 行政院衛生署中醫藥委員會中醫藥研究成果發表會 2000, 中華民國, 台北, 台北醫學院 .2000

33. 1999 Liu HC, Chen RM and Wang CH. Nitric oxide induces apoptosis of rat osteoblast-like cells. . The Ninth Sino-Japanese Orthopaedic Symposium. .1999

34. 1999 Liu HC, Lin FH and Chen RM. Sintered beta-dicalcium phosphate particles increase oxidative stress of rat osteoblasts-a possible mechanism of osteolysis. . The Orthopaedic Research Society, ROC, 1999 annual meeting. .1999

35. 1998 Chen RM, Hwang WP, Wang HW, Kuo ML and Ueng TH. Effects of motorcycle exhaust on cytochrome P450-dependent monooxygenases and glutathione S-transferase in rat tissues. . The Thirteenth Joint Annual Conference of Biomedical Science. Abstract 28. .1998

36. 1997 Ueng TH, Hwang WP, Wang HW and Chen RM. Effects of motorcycle emission particles on cytochrome P450-dependent monooxygenases in rat. . The Twelfth Joint Annual Conference of Biomedical Science. Poster 153 .1997 ;(12):235-235

37. 1996 Chen RM and Ueng TH. Evidence that acetone increases cytochrome P450 1A, 2B and 2E mRNA levels in hamster tissues. . The Eleventh Joint Annual Conference of Biomedical Science. Abstract 111 .1996 ;(11):108-108

38. 1993 Chen RM and Ueng TH. Differential effects of acetone administration on cytochrome P450-dependent monooxygenases in hamster tissues. . The Ninth Joint Annual Conference of Biomedical Science Abstract 159. .1993 ;(9):30-30

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科技部
計畫名稱
105 基質金屬蛋白酶-13在緩激肽調控血腦障壁通透性作用中所扮演的角色研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
104 緩激肽調控惡性神經膠瘤細胞基質金屬蛋白酶-13 表現和影響血瘤障壁通透性之研究
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
104 研發血液循環性和骨頭微型核醣核酸以做為診斷或治療男性骨質疏鬆症和其所誘發骨折的生物標誌(1/3)
補助單位
科技部
計畫名稱
104 研發血液循環性和骨頭微型核醣核酸以做為診斷或治療男性骨質疏鬆症和其所誘發骨折的生物標誌(1/3)
補助單位
科技部
計畫名稱
104 研發血液循環性和骨頭微型核醣核酸以做為診斷或治療男性骨質疏鬆症和其所誘發骨折的生物標誌-林千如
補助單位
科技部
計畫名稱
104 研發血液循環性和骨頭微型核醣核酸以做為診斷或治療男性骨質疏鬆症和其所誘發骨折的生物標誌-張偉華
補助單位
科技部
計畫名稱
104 N-methyl-D-aspartate receptor調控血腦障壁之角色探討
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
103 探討細胞自噬在低氧調控多型性神經膠母細胞瘤生成過程所扮演的角色
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
103 第四型TOLL-LIKE接受器與缺氧誘導因子-1在2,6-雙異丙烷酚保護血腦障壁免於腦部創傷所引起傷害過程中的角色探討(3-3)
補助單位
科技部
計畫名稱
103 探討GATA-DNA BINDING PROTEINS在骨頭癒合過程中所扮演的角色:轉譯醫學研究-林千如
補助單位
科技部
計畫名稱
103 探討GATA-DNA BINDING PROTEINS在骨頭癒合過程中所扮演的角色:轉譯醫學研究(3/3)
補助單位
行政院國家科學委員會
計畫名稱
103 第四型Toll-like接受器與缺氧誘導因子-1在2,6-雙異丙烷酚保護血腦障壁免於腦部創傷所引起傷害過程中的角色探討(3/3)
補助單位
科技部
計畫名稱
103 探討propofol減緩敗血症傷害的機轉: 轉譯醫學研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
102 miR106b抑制多型性神經膠母細胞瘤生長之角色研究
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
102 探討GATA-DNA BINDING PROTEINS在骨頭癒合過程中所扮演的角色:轉譯醫學研究(2/3)
補助單位
行政院國家科學委員會
計畫名稱
102 探討GATA-DNA BINDING PROTEINS在骨頭癒合過程中所扮演的角色:轉譯醫學研究(2/3)
補助單位
科技部
計畫名稱
102 探討GATA-DNA BINDING PROTEINS在骨頭癒合過程中所扮演的角色:轉譯醫學研究(3/3)
補助單位
科技部
計畫名稱
102 NSC102-2811-B-038-019-林千如(博)
補助單位
科技部
計畫名稱
102 Dexmedetomidine保護腦神經免於腦外傷傷害的轉譯醫學研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
101 研究血中特異microRNAs以做為診斷多型性神經膠母細胞瘤之生物標誌
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
101 探討GATA-DNA BINDING PROTEINS在骨頭癒合過程中所扮演的角色:轉譯醫學研究
補助單位
行政院國家科學委員會
計畫名稱
101 生醫材料PPC/PLA/TCP 彈性複合材料運用於骨頭修復之轉譯醫學研究 (A translational study on the effects of polypropylene carbonate/ poly(DL-lactic) acid/tricalcium phosphate elastic composite on bone repair)
補助單位
臺北科技大學
計畫名稱
101 CYP11A1在骨生成過程中所扮演的角色研究: 使用基因剃除鼠為實驗模式
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
101 生醫材料幾丁聚醣奈米纖維支架(chitosan nanofibers)影響骨母細胞分化 之分子機轉研究
補助單位
臺灣科技大學
計畫名稱
100 HIF-1和CREB在小鼠受到TBI損傷過程中所扮演的角色研究
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
100 Purinergic P2X2受體在退化性關節炎所誘發疼痛過程中所扮演的角色研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
99 微型核糖核酸(microRNAs)在骨母細胞的差異表現以及在調控細胞存活和代謝上可能扮演的角色研究
補助單位
行政院國家科學委員會
計畫名稱
98 嚴重腦外傷的病理研究- 探討miR-1和miR-210在低氧所處理神經細胞內的分子表現機制和調控細胞存活的角色
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)
計畫名稱
98 中草藥轉譯醫學之先導研究：傳統中藥骨碎補對骨折療效與骨母細胞分化之影響
補助單位
阮綜合醫療社團法人阮綜合醫院
計畫名稱
98 濫用藥物ketamine對人體膀胱危害之程度評估及機制探討(二)
補助單位
行政院衛生署藥物食品檢驗局
計畫名稱
98 核基質結合區域蛋白SATB2在調控骨母細胞存活與代謝上可能扮演的角色研究
補助單位
行政院國家科學委員會
計畫名稱
98 微型核糖核酸(microRNAs)在骨母細胞的差異表現以及在調控細胞存活和代謝上可能扮演的角色研究
補助單位
行政院國家科學委員會
計畫名稱
98 奈米級骨碎補水萃取物對骨母細胞存活及代謝活性的影響
補助單位
臺北醫學大學
計畫名稱
98 轉譯研究之先導行計畫：PROPOFOL於中風造成血腦障壁傷害過程中可能具有的保護作用研究
補助單位
臺北縣立醫院
計畫名稱
97 建立體外腦內皮細胞和體內動物腦損傷模式以評估健康食品對腦血管功能的保健功效
補助單位
行政院衛生署
計畫名稱
97 濫用藥物ketamine對人體膀胱危害之程度評估及機制探討(一)
補助單位
行政院衛生署管制藥品管理局
計畫名稱
97 轉錄因子GATAs (1-6)在骨母細胞中的差異表現以及其可能具有的抗細胞凋零角色研究(3-3)
補助單位
行政院國家科學委員會
計畫名稱
97 核基質結合區域蛋白SATB2在調控骨母細胞存活與代謝上可能扮演的角色研究
補助單位
行政院國家科學委員會
計畫名稱
97 Ketamine於脂磷壁酸所活化巨噬細胞中調控腫瘤壞死因子-α基因表現之分子機轉研究
補助單位
臺北縣立醫院
計畫名稱
96 Ketamine於脂多醣所活化巨噬細胞中可能具有抗炎作用之分子機轉
補助單位
臺北縣立醫院
計畫名稱
96 Ketamine調控人類肝臟細胞細胞支架重整和CYP450表現之研究
補助單位
國泰醫療財團法人國泰綜合醫院
計畫名稱
96 建立體外細胞與體內動物模式以探討俱樂部藥物ketamine和GHB對腦血管可能造成的毒性作用與分子積轉(一)
補助單位
行政院衛生署管制藥品管理局
計畫名稱
96 核基質結合區域蛋白SATB2在調控骨母細胞存活與代謝上可能扮演的角色研究(1-3)
補助單位
行政院國家科學委員會
計畫名稱
95 靜脈麻醉藥物PROPOFOL在脂磷壁酸所活化巨噬細胞影響一氧化氮生成之研究
補助單位
臺北醫學大學附設醫院
計畫名稱
95 氧化態低密度脂蛋白造成腦內皮細胞傷害的分子機轉
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
95 轉錄因子GATAs (1-6)在骨母細胞中的差異表現以及其可能具有的抗細胞凋零角色研究(1-3)
補助單位
行政院國家科學委員會
計畫名稱
95 轉錄因子GATAs (1-6)在骨母細胞中的差異表現以及其可能具有的抗細胞凋零角色研究(2-3)
補助單位
行政院國家科學委員會
計畫名稱
95 提昇私校研發能量專案計畫-探討氧化態低密度脂蛋白在中風疾病過程所扮演的病理角色-子計畫一：氧化態低密度脂蛋白調控腦內皮細胞LOX-1受體表現之分子機制研究(3-3)
補助單位
行政院國家科學委員會
計畫名稱
95 內生性和外生性一氧化氮誘導人類軟骨細胞凋零之機轉研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
94 細胞支架重整在一氧化氮誘導骨母細胞凋零中可能扮演之訊息傳遞角色
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
94 細胞支架重整在一氧化氮誘導骨母細胞凋零中可能扮演之訊息傳遞角色
補助單位
行政院國家科學委員會
計畫名稱
94 提昇私校研發能量專案計畫-探討氧化態低密度脂蛋白在中風疾病過程所扮演的病理角色-子計畫一：氧化態低密度脂蛋白調控腦內皮細胞LOX-1受體表現之分子機制研究2/3
補助單位
行政院國家科學委員會
計畫名稱
93 探討Ketamine對巨噬細胞可能造成的免疫調控作用與發生機轉
補助單位
行政院衛生署
計畫名稱
93 靜脈麻醉藥物得普利麻抗發炎與抗氧化之分子機制研究
補助單位
行政院國家科學委員會
計畫名稱
93 提昇私校研發能量專案計畫-探討氧化態低密度脂蛋白在中風疾病過程所扮演的病理角色-子計畫一：氧化態低密度脂蛋白調控腦內皮細胞LOX-1受體表現之分子機制研究1/3
補助單位
行政院國家科學委員會
計畫名稱
93 靜脈麻醉藥物ketamine對巨噬細胞活性可能造成的免疫抑制作用研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
92 一氧化氮誘導骨母細胞凋零機制研究：探討粒線體所扮演之角色　　
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
92 一氧化氮誘導骨母細胞凋零研究-探討Caspases所扮演之角色(2/2)
補助單位
行政院國家科學委員會
計畫名稱
92 得普利麻之抗氧化與抗發炎機制研究-探討Toll-like receptors所扮演之角色
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
91 一氧化氮誘導骨母細胞凋零研究-探討Caspases所扮演之角色(1/2)
補助單位
行政院國家科學委員會
計畫名稱
91 以體外與體內實驗模式探討2,6-雙異丙烷酚之抗發炎作用
補助單位
行政院國家科學委員會
計畫名稱
90 2,6-雙異丙烷酚於發生菌血症時所產生的抗氧化與抗發炎作用之研究: (I)調控一氧化氮與細胞素生成之體外研究
補助單位
行政院國家科學委員會
計畫名稱
89 Propofol 於內毒素誘導菌血症時調控巨噬細胞氧化壓力之研究
補助單位
行政院國家科學委員會
計畫名稱
88 麻醉藥物Diprivan 對人類內皮細胞衍生舒張因子作用之機制研究
補助單位
臺北醫學大學