林建煌(Lin Chien-Huang)　教授

Email
chlin@tmu.edu.tw
現   職
醫學科學研究所 教授

學經歷

學　歷

畢業學校與學位[修業時間]
台灣大學醫學院藥研所 博士
1991/09/01~1994/12/01
國立臺灣大學藥研所 碩士
1989/09/01~1991/06/01
臺灣大學管理學院EMBA 碩士
2009/06/01~2012/03/12
私立臺北醫學院藥學系 學士
1986/09/01~1989/06/01

本校學術經歷

任職單位與職稱[起迄時間]
醫學科學研究所教授
2007/08/01~
醫學研究所教授
2004/08/01~2007/07/31
醫事技術學系教授
2002/08/01~2004/07/31
醫事技術學系副教授
1997/07/01~2002/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際醫學研究碩士學位學程教授
2018/02/01 ~
國際醫學研究博士學位學程教授
2018/02/01 ~
(舊)細胞治療與再生醫學國際博士學位學程籌備處教授
2018/02/01 ~
校長室校長
2017/08/01 ~ 2023/07/31
國際醫學研究博士學位學程教授
2016/11/01 ~ 2017/10/31
國際醫學研究碩士學位學程教授
2016/11/01 ~ 2017/10/31
(舊)生技醫療產業研發博士學位學程教授
2016/08/01 ~ 2017/07/31
管理學院代理院長
2016/02/01 ~ 2016/07/31
(舊)醫學工程學院籌備處代理主任
2015/05/01 ~ 2015/05/30
校務研究辦公室(舊)執行長
2014/12/22 ~ 2015/11/05
副校長室副校長
2014/11/01 ~ 2017/07/31
轉譯醫學博士學位學程
2014/02/01 ~
教師發展中心(舊)主任
2013/01/01 ~ 2013/07/31
秘書處主任秘書
2012/08/01 ~ 2014/10/31
秘書室主任秘書
2011/10/01 ~ 2012/07/31
藥理學科教授
2009/09/01 ~
教務處教務長
2009/08/01 ~ 2011/09/30
通識教育中心(舊一)主任
2009/08/01 ~ 2010/07/31
醫學科學研究所所長
2007/08/01 ~ 2009/01/31
醫學研究所所長
2004/09/10 ~ 2007/07/31
研究發展處研發長
2003/09/15 ~ 2009/07/31
創新育成中心主任
2003/09/15 ~ 2004/07/31
呼吸治療學系主任
2001/08/01 ~ 2004/09/30
研究教學組組長
2000/08/01 ~ 2003/09/15

其它經歷

任職單位與職稱[起迄時間]
國防醫學院生理及生物物理學科博士後研究
1995/07/01~1997/05/31
台大醫學院藥理研究所博士後研究
1995/01/01~1995/06/30

專長與研究領域

學門領域
訊號傳遞 (signal transduction)
炎症藥理學 (inflammation Pharmacology)
細胞生理學(cell biology)
學術專長
西方墨點法 (Western blot)
流式細胞儀 (flowcytometry)
電泳移動偏向分析法(EMSA)

論文著作

清冊下載

論文 Journal Paper


1. 2023 Hua HS,Wen HC,Lee HS,Weng CM,Yuliani FS,Kuo HP, Chen BC, Lin CH. Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex . J. Biomed. Sci. .2023 ;(30)

2. 2023 Weng CM,Lee MJ,Chao W,Lin YR,Chou CJ,Chen MC, Chou CL, Tsai IL, Lin CH, Chung KF, Kuo HP. Airway epithelium IgE-FcεRI cross-link induces epithelial barrier disruption in severe T2-high asthma . Mucosal Immunol. .2023 ;(16):685-698

3. 2022 Lee MJ,Weng CM,Chao W,Fang YF,Chung FT,Lin CH, Kuo HP. Platelet Activation in High D-dimer Plasma Plays a Role in Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Mutant Lung Adenocarcinoma . Frontiers in Oncology .2022 ;(12)

4. 2022 Yuliani FS,Chen JY,Cheng WH,Wen HC,Chen BC,Lin CH. Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells . Journal of Biomedical Science .2022 ;(29):95-95

5. 2022 Yeh LY,Fang YT,Lee HS,Liu CH,Chen YY,Lo YC, Laiman V, Liou JP, Chung KF, Chuang HC, Lin CH. A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model . Frontiers in Medicine .2022 ;(9)

6. 2022 Cheng WH,Kao SY,Chen CL,Yuliani FS,Lin LY,Lin CH, Chen BC. Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells . Respiratory Research .2022 ;(23):381

7. 2021 Cheng WH,Chen CL,Chen JY,Lin CH,Chen BC. Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway . Molecular Medicine .2021 ;(27):69-69

8. 2021 Hua HS,Wen HC,Weng CM,Lee HS,Chen BC,Lin CH. Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation . J. Biomed. Sci .2021 ;(28):38-38

9. 2021 Chen JY,Cheng WH,Lee KY,Kuo HP,Chung KF,Chen CL, Chen BC, Lin CH. Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma . Biomed. Pharmacother. .2021 ;(140):1-12

10. 2021 Hsu KC,Chu JC,Tseng HJ,Liu CI,Wang HC,Lin TE, Lee HS, Hsin LW, Wang HJ, Lin CH , Huang WJ. Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors . Eur J Med Chem. .2021 ;(219):113419-113419

11. 2021 Cheng WH,Lee KY,Yu MC,Chen JY,Lin CH,Chen BC. Pref-1 induced lung fibroblast differentiation by hypoxia through integrin α5β1/ERK/AP-1 cascade . Eur J Pharmacol. .2021 ;(909)

12. 2020 Lin CH,Shih CH,Jiang CP,Wen HC,Chen BC. Mammalian target of rapamycin and p70S6 kinase mediate thrombin-induced nuclear factor-κB activation and interleukin-8/CXCL8 release in human lung epithelial cells. . Eur J Pharmacol. .2020 ;(868):172879-172887

13. 2020 Ou, S.C.,Bai, K.J.,Cheng, W.H.,Lin, C.H.,Wen, H.C.,Chen, B.C.. TGF-β induced CTGF expression in human lung epithelial cells through ERK, ADAM17, RSK1, and C/EBPβ pathways. . Int. J. Mol. Sci. .2020

14. 2019 Chen YC,Chen BC,Huang HM,LIN SH,LIN CH. Activation of PERK in ET‐1‐ and thrombin‐induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin . J. Cell Physiol. .2019 ;(2019):1-12

15. 2019 Lee HS,Hua HS,Wang CH,Yu MC,Chen BC,Lin CH. Mycobacterium tuberculosis induces connective tissue growth factor expression through the TLR2/JNK/AP-1 pathway in human lung fibroblasts. . FASEB J. .2019 ;(33):12554-12564

16. 2018 Lin CH,Shih CH,Lin YC,Yang YL,Chen BC. MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts . J. Biomed. Sci. .2018 ;(25):19-19

17. 2018 Chen HY,Lin CH,Chen BC. ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts . Experimental Cell Research .2018 ;(370):39-45

18. 2017 Chen JY,Lin CH,Chen BC. Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBPβ activation in human lung fibroblasts. . Mol. Immunol. .2017 ;(88):155-163

19. 2017 Huang ZW,Lien GS,Lin CH,Jiang CP,Chen BC. p300 and C/EBPβ-regulated IKKβ expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells. . Pharmacol Res. .2017 ;(121):33-41

20. 2016 Chen YC,Chen BC,Yu CC,Lin SH,Lin CH. miR-19a, -19b, and -26b Mediate CTGF Expression and Pulmonar Fibroblast Differentiation. . J. Cell. Physiol. .2016 ;(231):2236-2248

21. 2016 Lien GS,Lin CH,Yang YL,Wu MS,Chen BC. Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways. . Eur. J. Pharmacol. .2016 ;(776):124-131

22. 2016 Cheng Y,Lin CH,Chen JY,Li CH,Liu YT,Chen BC. Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI- 1/GLI-2 and AP-1 Pathways . PLOS ONE .2016 ;(11):0-0

23. 2015 Lin CH,Shih CH,Chen BC. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells . Eur. J. Pharmacol. .2015 ;(767):135-143

24. 2015 Lin CH,Wang YH,Chen YW,Lin YL,Chen BC,Chen MC. Transcriptional and posttranscriptional regulation of CXCL8/ IL-8 gene expression induced by connective tissue growth factor . Immunol Res. .2015 ;(64):369-384

25. 2014 Weng CM,Yu CC,Kuo ML,Chen BC,Lin CH. Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway . Biochemical Pharmacology .2014 ;(88):402-411

26. 2014 Huang LT,Lin CH,Chou HC,Chen CM. Ibuprofen protects ventilator-induced lung injury by down regulating rho-kinase activity in rats . Biomed. Res. Int. .2014 ;(2014):749097

27. 2014 Lien GS,Wu MS,Bien MY,Chen CH,Lin CH,Chen BC. Epidermal growth factor stimulates nuclear factor-kB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells . PLoS One .2014 ;(9)

28. 2014 Lin CH,Shih CH,Tseng CC,Yu CC,Tsai YJ,Bien MY, Chen BC. CXCL12 Induces Connective Tissue Growth Factor Expression in Human Lung Fibroblasts through the Rac1/ ERK, JNK, and AP-1 Pathways . PLoS One .2014 ;(9):1-16

29. 2014 Lin CH,Nai PL,Bien MY,Chen BC. Thrombin-induced CCAAT/enhancer-binding protein  activation and IL-8/CXCL8 expression via MEKK1, ERK, and p90 ribosomal S6 kinase 1 in lung epithelial cells . J. Immunol. .2014 ;(192):338-348

30. 2014 Huang, KH,Wang, CH,Lin, CH,Kuo, HP. NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes . Journal of Biomedical Science .2014 ;(21):71-71

31. 2013 Lin CH,Chiang CC,Bien MY,Chien MH,Chen BC. Thrombin-iinduced NF-kB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells . Cell. Signal .2013 ;(25):1166-1175

32. 2013 Weng CM,Chen BC,Wang CH,Feng PH,Lee MJ,Huang CD, Kuo HP, Lin CH. The ETA Receptor Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma: The Involvement of CTGF . Am. J. Respir. Crit. Care Med. .2013 ;(188):298-308

33. 2013 Lin CH,Yu MC,Tung WH,Chen TT,Tsai YJ,Bai KJ, Hong CY, Chien MH, Chen BC. Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway . Biochim. Biophys. Acta.-Mol. Cell Res. .2013 ;(1833):2823-2833

34. 2013 Weng CM,Chen BC,Wang CH,Feng PG,Huang CD,Kuo HP, Lin CH. ETA receptor mediated fibrocyte differentiation in chronic obstructive asthma: involvement of CTGF . Am. J. Respir. Dis. Crit. Med. .2013 ;(118):298-308

35. 2013 Huang KH,Wang CH,Lee KY,Lin SM,Lin CH,Kuo HP. NF-kB Repressing Factor Inhibits Chemokine Synthesis by Peripheral Blood Mononuclear Cells and Alveolar Macrophages in Active Pulmonary Tuberculosis . PLOS ONE .2013 ;(8):e77789-12

36. 2012 Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC, Chiu WT, Lin CH. Zerumbone suppresses IKKα, Akt, and FOX01 activation, resulting in apoptosis of GBM 8401 cells . Journal of Biomedical Science .2012 ;(19):86-86

37. 2012 Weng HY,Hsu MJ,Chen CC,Chen BC,Hong CY,Teng CM, Pan SL, Chiu WT, Lin CH. Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade . European Journal of Pharmacology .2012 ;(698):103-109

38. 2012 Bai KJ,Chen BC,Pai HC,Weng CM,Yu CC,Hsu MJ, Yu MC, Ma HP, Wu CH, Hong CY, Kuo ML, Lin CH. Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway . Journal of Leukocyte Biology .2012 ;(93):101-112

39. 2011 Ko WC,Chen BC,Hsu MJ,Tsai CT,Hong CY,Lin CH. Thrombin induced connective tissue growth factor expression in vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway . Acta Pharmacol. Sin. .2011 ;(33):49-56

40. 2011 Lin CH,Cheng HW,Ma HP,Wu CH,Hong CY,Chen BC. Thrombin induces NF-kB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway . J. Biol. Chem. .2011 ;(286):10483-10494

41. 2010 Hsu MJ,Chang CK,Chen MC,Chen BC,Ma HP,Hong CY, Lin CH. Apoptosis signal regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages . J. Leukocyte Biol. .2010 ;(87):1069-1082

42. 2010 Tzeng JI,Chen BC,Chang HM,Wang JJ,Sureshbabu M,Chien MH, Hsu MJ, Bien MY, Chiu WT, Hong CY, Lin CH. Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-kB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages . Pharmacol Res. .2010 ;(61):162-166

43. 2009 Tzeng JI,Chen BC,Chang HM,Wang JJ,Sureshbabu M,Chien MH, Hsu MJ, Bien MY, Chiu WT, Hong CY, Lin CH. Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages . Pharmacologic Research (accepted) .2009 ;(xxx):xxx-xxx

44. 2009 Chen BC,Kang JC,Lu YT,Hsu MJ,Liao CC,Chiu WT, Yeh FL, Lin CH. Rac1 regulates peptidoglycan-induced nuclear factor-kB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway . Mol. Immunol. .2009 ;(46):1179-1188

45. 2009 Yu CC,Hsu MJ,Kuo ML,Chen MC,Bai KJ,Yu MC, Chen BC, Lin CH. Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway . J. Immunol. .2009 ;(182):7916-7927

46. 2009 Chang MS,Chen BC,Weng CM,Lee WS,Lin CH. Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells . Pharmacol Res. .2009 ;(60):247-253

47. 2009 Chow JM,Lin HY,Shen SC,Wu MS,Lin CW,Lin CH, Chen YC. Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-Induced nitric oxide production through stimulating iNOS protein ubiquitination . Toxicol. Appl. Pharmacol. .2009 ;(237):357-365

48. 2009 Kuo CT,Chen BC,Yu CC,Weng CM,Hsu MJ,Chen CC, Chen MC, Teng CM, Pan SL, Bien MY, Shih CH, Lin CH. Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells . J. Biomed. Sci. .2009 ;(16):43-58

49. 2009 Ho SC,Lee KY,Chan YF,Kuo LW,Ito K,Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP. Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kB repressing factor . J. Immunol. .2009 ;(183):411-420

50. 2009 Chen BC,Chang HM,Hsu MJ,Chiu WT,Lin CH. Peptidoglycan induces cyclooxygenase-2 expression in RAW 264.7 macrophages by activation the neutral sphingomyelinase-ceramide pathway. . J. Biol. Chem. .2009 ;(284):20562-20573

51. 2009 Hsu MJ,Sheu JR,Lin CH,Shen MY,Hsu CY. Mitochondrial mechanisms in amyloid beta peptide-induced cerebraovascular degeneration . Biochim. Biophys. Acta. (In press) .2009

52. 2009 Shih CH,Bien MY,Chiang LL,Su CL,Lin CH,Chen BC. Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kB pathways in human lung fibroblasts . Eur. J. Pharmacol. .2009 ;(618):70-75

53. 2008 Shen MY,Hsiao G,Fong TH,Chen HM,Chou DS,Lin CH, Sheu JR, Hsu CY. Amyloid beta peptide-activated signaling pathway in human platelets . Eur. J. Pharmacol. .2008 ;(588):259-266

54. 2008 Wang SY,Tsai CM,Chen BC,Lin CH,Lin CC. Symptom clusters and relationships to symptom interference with daily life in Taiwanese lung cancer patients . J. Pain Symptom Manag. .2008 ;(27):5719-5729

55. 2008 Kuo CT,Hsu MJ,Chen BC,Teng CM,Pan SL,Chen CC, Lin CH. Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction. . Toxicol. Lett. .2008 ;(177):48-58

56. 2008 Chen BC,Kang JC,Lu YT,Hsu MJ,Liao CC,Chiu WT, Yeh FL, Lin CH. Rac1 regulates peptidoglycan-induced nuclear factor-kB activation and cyclooxygenase-2 expression in RAW264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway . Molecular Immunology .2008 ;(000):000-000

57. 2007 Hsu MJ,Hsu CY,Chen BC,Chen MC,Ou G,Lin CH. ASK1 in amyloid β peptide-induced cerebral endothelial cell apoptosis. . J. Neurosci. .2007 ;(27):5719-5729

58. 2007 Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ, Chen BC. Transforming growth factor-β 1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kB pathways in human lung epithelial cells. . Eur. J. Pharmacol. .2007 ;(560):101-109

59. 2006 Chen BC,Liao CC,Hsu M.J.,Liao YT,Lin CC,Sheu JR, Lin CH. Peptidoglycan-Induced Interleukin-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, EP2/EP4 Receptors, Protein Kinase A, IκB Kinase, and Nuclear Factor-κB . J. Immunol. .2006 ;(177):681-693

60. 2006 Hsiao G,Chen YC,Lin JH,Lin KH,Chou DS,Lin CH, Sheu JR. Inhibitory mechanisms of tertramethylpyrazine in middle cerebral occulusion (MCAO)-induced focal cerebral ischemia in rats . Planta Medica .2006 ;(72):411-417

61. 2006 Lin CH,Cheng HW,Hsu MJ,Chen MC,Lin CC,Chen BC. c-Src mediates thrombin-induced NF-kB activation and interleukin-8 expression in lung epithelial cells . J. Immunol. .2006 ;(177):3427-3438

62. 2006 Chang YC,Li PC,Chang MS,Chiu WT,Lin CH. Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kB pathway . Cellular Signaling .2006 ;(18):1235-1243

63. 2005 Chang MS,Chen BC,Yu MT,Sheu JR,Chen TF,Lin CH. Phorbol-12-myristate-13-acetate up-regulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kB, but not p38 MAPK, pathways . Cellular Signaling .2005 ;(17):299-310

64. 2005 Kao SJ,Lei HC,Kuo CT,Chang MS,Chen BC,Chang YC, Chiou WT, Lin CH. Lipoteichoic acid induces nuclear factor-kB activation and nitric oxide synthase expression via phosphatidylinositiol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages . Immunolgy .2005 ;(115):366-374

65. 2005 Wang YC,Lin CH,Chen CM,Liou JP. A concise synthesis of denbinobin. . Tetrahedron Let. .2005 ;(46):8103-8104

66. 2005 Hsiao G,Chou PH,Shen MY,Chou DS,Lin CH,Sheu JR. C-Phycocyanin, a Very Potent and Novel Platelet Aggregation Inhibitor from Spirulina platensis. . J. Agri. Food Chem. .2005 ;(53):7734-7740

67. 2004 Chen HC,Lin HC,Liu CY,Wang CH,Hwang T,Huang TT, Lin CH, Kuo HP. Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway. . J. Biomed. Sci. .2004 ;(11):49-58

68. 2004 Hsiao G,Shen MY,Chou DS,Lin CH,Chen TF,Sheu JR. Involvement of the antiplatelet activity of magnesium sulfate in suppression of prortein kinase C and the Na+/H+ exchanger. . J. Biomed. Sci. .2004 ;(11):19-26

69. 2004 Hsiao G,Huang HY,Fong TH,Shen MY,Lin CH,Teng CM, Sheu JR. Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages. . Biochem. Pharmacol. .2004 ;(67):1411-1419

70. 2004 Chen BC,Chang YS,Kang JC,Hsu MJ,Sheu JR,Chen TL, Lin CH. Peptidoglycan induces nuclear factor-kB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages. . J. Biol. Chem. .2004 ;(279):20889-20897

71. 2004 Hsiao G,Shen MY,Chou DS,Chang Y,Lee LW,Lin CH, Sheu JR. Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies. . Eur. J. Pharmacol. .2004 ;(487):155-166

72. 2004 Chang MS,Lee WS,Chen BC,Sheu JR,Lin CH. YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, Akt, and NF-kB in human pulmonary epithelial cell . Mol. Pharmacol. .2004 ;(66):561-571

73. 2004 Chen BC,Yu CC,Lei HC,Chang MS,Hsu MJ,Huang CL, Chen MC, Sheu JR, Lin CH. Bradykinin B2 receptor mediates nuclear factor-kB activation and cyclooxygenase-2 expression via Ras/Raf-1/ERK pathway in human airway epithelial cells . J. Immunol. .2004 ;(173):5219-5228

74. 2003 Kuo CS, Chiang LL, Lee CN, Yu MT, Pei KZ, Lee HM, Lee WS, Sheu JR and Lin CH. Induction of inducible nitric oxide synthase in RAW 264.7 macrophages by lipoteichoic acid derived from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms. . J. Biomed. Sci. .2003 ;(10):136-145

75. 2003 Chiang LL., Kuo CT, Wang CH, Lee HM, Ho YS, Kuo HP and Lin CH. Involvement of nuclear factor-kB in lipoteichoic acid-induced macrophage cyclooxygenase-2 expression . J. Pharm. Pharmacol. .2003 ;(55):1-7

76. 2003 Hsu HK, Juan SH, Ho PY, Liang YC, Lin CH, Teng CM and Lee WS. YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway . Biochem. Pharmacol. .2003 ;(66):263-271

77. 2003 Wu CH, Chang CH, Lin HC, Chen CM, Lin CH and Lee HM. Role of PKC in BSA-AGEs-mediated inducible nitric oxide synthase expression in RAW 264.7 macrophages . Biochem. Pharmacol. .2003 ;(66):203-212

78. 2003 Wang CH, Lin HC, Lin CH, Yu CT, Liu SL, Huang KH, Chung KF and Kuo HP. Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma . Br. J. Pharmacol. .2003 ;(138):1147-1155

79. 2003 Lee WS, Chen RJ, Wang YJ, Jeng JH, Liang YC, Chen CH, Lin CH, Lin JK, Ho PY, Chu JS, Ho WL, Chen LC and Ho YS. In vitro and in vivo studies of the anti-cancer action of terbinafine in human cancer cell lines . Int. J. Cancer .2003 ;(106):125-137

80. 2003 Hsiao G, Shen MY, Lin KH, Chou CY, Tzu, NH, Lin CH, Chou DS, Chen TF and Sheu JR. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombous in vivo . Eur. J. Pharmacol. .2003 ;(465):281-287

81. 2003 Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH, Sheu JR. Comparison of the binding character of triflavin and on resting and activated aIIbb3 integrin in human platelets by electron microscopy. . Throm. Res. .2003 ;(109):37-46

82. 2003 Hsiao G,Shen MY,Lin KH,Lan MH,Wu LY,Chou DS, Lin CH, Su CH, Sheu JR. Antioxidative and hepatoprotective effects of Antrodia camphorata Extract. . J. Agri. Food Chem. .2003 ;(51):3302-3308

83. 2003 Hsiao G,Shen MY,Fang CL,Chou DS,Lin CH,Chen CF, Sheu JR. Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments. . J. Biomed. Sci. .2003 ;(10):292-301

84. 2003 Liu CY,Liu YH,Lin SM,Yu CT,Wang CH,Lin HC, Lin CH, Kuo HP. Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment. . J. Biomed. Sci. .2003 ;(10):746-756

85. 2003 Sheu JR,Hsiao G,Shen MY,Chou CY,Lin CH,Chen TF, Chou DS. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. . Platelets .2003 ;(14):189-196

86. 2003 Sheu JR,Hsiao G,Shen MY,Wang Y,Lin KH,Lin CH, Chou DS. Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments. . Exp. Biol. Med. .2003 ;(228):1321-1328

87. 2002 Yang LL, Liang YC, Chang CW, Lee WS, Kuo CT, Wang CC, Lee HM and Lin CH. Effects of sphondin, isolated from Heracleum laciniatum, on IL-1b-induced cyclooxygenase-2 expression in human pulmonary epithelial cells . Life Sci. .2002 ;(72):199-213

88. 2002 Lin SY, Liu JD, Chang HC, Yeh SD, Lin CH, Lee WS. Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. . J. Cell. Biochem. .2002 ;(84):532-544

89. 2002 Sheu JR, Hsiao G, Lin WY, Chen TF, Chien YY, Lin CH, Tzeng CR. Mechanisms involved in agonist-induced hyperaggreability of platelets from normal pregnancy. . J. Biomed. Sci. .2002 ;(9):17-25

90. 2002 Sheu JR, Hsiao G, Luk HN, Chen YW. Chen TL, Lee LW, Lin CH, Chou DS. Mechanisms involved in the antiplatelet activity of midazolam in human platelets. . Anesthesiology .2002 ;(96):651-658

91. 2002 Lin CH, Wu CH, Thum WY, Ho YS, Lee HM. Involvement of p38 mitogen activated protein kinase in PLL-AGE-induced cyclooxygenase-2 expression in mouse RAW 264.7 macrophages . Eur. J. Pharmacol. .2002 ;(438):143-152

92. 2002 Wu CH, Jeng JH, Wang YJ, Tseng CJ, Liang YC, Chen CH, Lee HM, Lin JK, Lin CH, Lin SY, Li CP, Ho YS. Antitumor effects of miconazole on human colon carcinoma xenographs in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. . Toxicol. Appl. Pharmacol. .2002 ;(180):22-35

93. 2002 Chang MS, Lee WS, Teng CM, Lee H., Sheu JR, Hsiao G, Lin CH. YC-1 increases cyclooxygenase-2 expression by protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells. . Br. J. Pharmacol. .2002 ;(136):558-567

94. 2002 Chen CM, Wu CH, Lin CH, Chang CS and Lee HM. Involvement of cAMP dependent protein kinase in BSA-AGEs-induced iNOS expression and nitrite production in RAW 264.7 macrophages. . New Taipei J. Med. .2002 ;(4):108-116

95. 2002 Lin CH, Chang CW, Wang CC, Chang MS and Yang LL. Byakangelicol, isolated from Angelica daburica, inhibits both the activity and COX-2 induction in human pulmonary epithelial cells. . J. Pharm. Pharmacol. .2002 ;(54):1271-1278

96. 2002 Wang YJ, Jeng JH, Chen RJ, Chen LC, Liang YC, Lin CH, Chen CH, Chu JS, Ho WL and Ho YS. Ketoconazole potentiates the antitumor effects of nocodazole: in vivo therapy of human tumor xenografts in nude mice . Mol. Carcinogen. .2002 ;(34):199-210

97. 2002 Wu CH, Huang CM, Lin CH, Ho YS and Lee HM. Advanced glycosylation end products induce NF-kB dependent iNOS expression in RAW264.7 cells. . Mol. Cell. Endocrinol. .2002 ;(194):9-17

98. 2002 Lin CH, Kuan IH, Wang CH, Lee HM, Lee WS, Sheu JR, Hsiao G, Wu CH and Kuo HP. Lipoteichoic acid-induced cyclooxygenase-2 expression in human pulmonary epithelial cells requires activations of p44/42 and p38 MAPK signal pathways. . Eur. J. Pharmacol. .2002 ;(450):1-9

99. 2001 Lin CH, Lin YF, Chang MC, Ho YS and Lee HM. Advanced glycosylation end products induce nitric oxide synthase expression in C6 glioma cells: Involvement of p38 MAP kinase-dependent mechanism. . Life Sci. .2001 ;(69):2503-2515

100. 2001 Lin CH, Kuan IH, Lee HM, Lee WS, Sheu JR, Ho YS, Wang CH and Kuo HP. Induction of cyclooxygenase-2 protein in human pulmonary epithelial cells by lipoteichoic acid derived from Staphylococcus aureus: Involvement of a nuclear factor-kB-dependent pathway. . Br. J. Pharmacol. .2001 ;(134):543-552

101. 2001 Ho YS, Dun JS, Jeng JH, Wang YJ, Liang YC, Lin CH, Tseng CJ, Yu CF, Chen RJ and Lin JK. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells . Int. J. Cancer .2001 ;(91):393-401

102. 2001 Sheu JR, Hsiao G, Lee CR, Chang WC, Lee LW, Su CH and Lin CH. Mechanisms involved in the inhibition of neointimal hyperplasia by triflavin a rat model of ballon angioplasty . J. Lab. Exp. Med. .2001 ;(137):270-278

103. 2001 Hsiao G, Lin YH, Lin CH, Chou DS, Lin WC, Sheu JR. The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo. . Biol. Pharm. Bull. .2001 ;(24):1271-1276

104. 2000 Sheu JR, Kan YC, Hung WC, Lin CH and Yen MH. The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase. . Life Sci. .2000 ;(67):937-947

105. 2000 Sheu JR, Lee CR, Lin CH, Hsiao G, Ko WC, Chen YC and Yen MH. Mechanisms involved in the antiplatelet activity of staphylococcus aureaus lipoteichoic acid in human platelets . Thromb. Haemost. .2000 ;(83):777-784

106. 2000 Luo SF, Wang CC, Chiu CT, Chien CS, Hsiao LD, Lin CH and Yang CM.. Lipopolysaccharide enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells . Br. J. Pharmacol. .2000 ;(130):1799-1808

107. 2000 Sheu JR, Hsiao G, Lee CR, Chang WC, Lee LW, Su CH and Lin CH. Antiplatelet activity of staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway . Thromb. Res. .2000 ;(99):249-258

108. 2000 Chen RJ, Lee WS, Liang YC, Lin JK, Wang YJ, Lin CH, Hsieh JY, Chaing CC and Ho YS. Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines . Toxicol. Appl. Pharmacol. .2000 ;(169):132-141

109. 2000 Wu CH, Chen YC, Hsiao G, Lin CH, Liu CM and Sheu JR. Mechanisms involved in the inhibition of neointimal hyperplasia by abciximab in a rat model of ballon angioplasty . Thromb. Res. .2000 ;(101):1-12

110. 2000 Lin CH, Sheu SY, Lee HM, Ho YS, Lee WS, Ko WC and Sheu JR. Involvment of protein kinase C-r in IL-1b-induced cyclo-oxygenas-2 expression in human pulmonary epithelial cells. . Mol. Pharmacol. .2000 ;(57):36-43

111. 1999 Ko WC, Kuo SW, Sheu JR, Lin CH, Tzeng SH and Chen CM. Relaxant effects of quercetin methyl ether derivatives in isolated guinea-pig trachea and their structure-activity relationships . Planta Medica .1999 ;(65):273-275

112. 1999 Ko WC, Kuo SW, Sheu JR, Lin CH, Tzeng SH and Chen CM. Relaxant action mechanisms of quercetin 3,3',4'5,7-pentamethyl ether in isolated guinea-pig trachea. . New Taipei Journal of Medicine .1999 ;(2):98-106

113. 1999 Lee LW, Peng HC, Ko WC, Hung WC, Su CH, Lin CH, Huang TF, Yen MH and Sheu JR. Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation. . Eur. J. Pharmacol. .1999 ;(364):239-246

114. 1999 Sheu JR, Hung WC, Su CH, Lin CH, Lee LW, Lee YM and Yen MH. The antiplatelet activity of Escherichia coli lipopolysaccharide is mediated through a nitric oxide/cyclic GMP pathway. . Eur. J. Haematol. .1999 ;(62):317-326

115. 1999 Sheu JR, Hung WC, Wu CH, Ma MC, Kan YC, Lin CH, Lin MS, Luk HN and Yen MH. Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia. . Circulation .1999 ;(22):3056-3062

116. 1999 Sheu JR, Lee CR, Lin CC, Kan YC, Lin CH, Hung WC, Lee YM and Yen MH. The antiplatelet activity of PMC, a potent a-tocopherol analogue, is mediated through inhibition of cyclooxygenase. Br. . J. Pharmacol. .1999 ;(127):1206-1212

117. 1998 Lin CH, Lee YM, Sheu JR, Cheng CY, Chang MJ and Yen MH. Pharmacological characteristics of MJ-451, a new benzopyran-derived ATP-sensitive potassium channel opener, in guinea-pig isolated trachea. . Pharmacology .1998 ;(57):314-322

118. 1998 Lee HM, Tsai KJ, Lin CH, Huang CL and Tung CS. Arecholine desensitizes carbachol-stimulated phosphatidylinositiol breakdown in rat brain cortices. . J. Neurochem. .1998 ;(70):1189-1198

119. 1998 Sheu JR, Kan YC, Hung WC, Su CH, Lin CH, Lee YM and Yen MH. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. . Throm. Res. .1998 ;(92):53-64

120. 1997 Lin CH, Ko FN, Ishii H, Ishikawa T, Chen IS, Teng CM and Kuo HP. The effects of the selective PAF receptor antagonist CIS-19 on PAF- and antigen-induced bronchoconstriction, microvascular leakage and bronchial hyperreactivity in guinea-pigs. . Naunyn-Schiedeberg's Arch Pharmacol. .1997 ;(355):210-216

121. 1996 Lin CH, Yang CM, Chen CM, Ko FN and Teng CM. Pharmacological characteristics of BDTI, a new isoquinolone-derived b2-adrenoceptor agonist, in canine trachea and rat heart. . Pharmacology .1996 ;(53):19-27

會議論文 Conference Paper


1. 2002 Lin CH,Kuo CS. Induction of inducible nitric oxide synthase in RAW 264.7 macrophages by lipoteichoic acid derived from Staphylococcus aureus: involvement of PKC- and NF-kB-dependent mechanisms. . XII International Vasacular Biology Meeting (IVBM2002), Karuitzawa, Japan, No.10332. .2002

2. 2001 Lin CH,Kuan IH,Chang MS. Induction of cyclooxygenase-2 protein by lipoteichoic acid derived from Staphylococcus aureus in human pulmonary epithelial cells: Involvement of a nuclear factor-kB-dependent pathway. . 11th Annual ERS Congress Berlin 2001, Germany .2001

3. 2001 Lin CH,Wu CH,Thum WY,Lee HM. Involvement of p38 mitogen-activated protein kinase in advanced glycosylation end products-induced cyclooxygenase-2 expression in RAW 264.7 macrophages . 11th International Conference Second Messengers & Phosphoproteins, Australia, No.486. .2001

4. 2001 Lin CH,Kuan IH,Lee HM. Lipoteichoic acid-induced cyclooxygenase-2 expression in human pulmonary epithelial cells requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways . 11th International Conference Second Messengers & Phosphoproteins, Australia, No.760. .2001

5. 2001 Lin CH,Wu CH,Thum WY,Lee HM. Involvement of p38 mitogen-activated protein kinase in PLL-AGEs-induced cyclooxygenase-2 expression and PGE2 production in RAW 264.7 macrophages . The Sixteenth Joint Annual Conference of Biomedical Science, Taiwan, R.O.C., No.P297. .2001

6. 2000 Lin CH,Chang MS. Phorbol-12-Myristate-13-Acetate-induced cyclooxygenase-2 expression is mediated through protein kinase C-a in human pulmonary epithelial cells (A549). . ATS 2000*TOROThe 96th International Conference, Canada, No.B55. .2000

7. 1999 Lin CH,Sheu SY. Involvment of protein kinase C-g in IL-1b-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. . The 8th Southern Asia-Western Pacific Regional Meeting of Pharmacologists, Taiwan, R.O.C., No.P087. .1999

8. 1999 Lin YF,Lin CH,Wu SS,Lee HM. Advanced glycosylation end products induced COX-2 expression in C6 glioma cells. . The Fourteenth Joint Annual Conference of Biomedical Science, Taiwan, R.O.C., No.300. .1999

9. 1999 Sheu SY,Lee HM,Lin CH. Involvment of protein kinase C-g in induction of cyclooxygenase-2 stimulated by IL-1b in human pulmonary epithelial cells. . The Fourteenth Joint Annual Conference of Biomedical Science, Taiwan, R.O.C., No.128. .1999

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科技部
計畫名稱
102 肺纖維化之轉譯研究－組蛋白去乙醯酶2的SUMO化修飾貢獻於慢性阻塞性氣喘的結締組織生長因子表現與肺部纖維化反應
補助單位
臺北醫學大學
計畫名稱
101 總計畫：纖維球細胞在肺纖維化角色探討-子計畫一：內皮素媒介慢性阻塞性氣喘之纖維球分化反應
補助單位
行政院國家科學委員會
計畫名稱
101 結核桿菌引發肺部及肋膜纖維化之轉譯研究
補助單位
行政院國家科學委員會
計畫名稱
101 內皮素媒介慢性阻塞性氣喘之纖維球分化反應
補助單位
臺北醫學大學
計畫名稱
100 JAK/STAT及casein kinase訊息路徑參與interleukin-6誘導人類肺纖維母細胞CTGF表現及肺部纖維化之研究
補助單位
行政院國家科學委員會
計畫名稱
100 總計畫：纖維球細胞在肺纖維化角色探討-子計畫一：內皮素媒介慢性阻塞性氣喘之纖維球分化反應
補助單位
行政院國家科學委員會
計畫名稱
99 凝血刺激人類肺部纖維母細胞結締組織生長因子表現的分子機制探討
補助單位
行政院國家科學委員會
計畫名稱
98 ASK1在bradykinin刺激肺部纖維母細胞CTGF表現之訊息傳遞路徑研究
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
98 c-Src/JAK2/STAT3在凝血酵素誘發肺纖維母細胞結締組織生長因子之角色探討
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
98 Fibrocytes在敗血症所誘導之急性肺損傷中扮演的角色探討
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
98 Toll-like receptor 2-Mediated Inflammatory Mechanisms Induced by Peptidoglycan-研究複合體p85alpha/c-Src/p47phox的形成在PGN誘導NADPH oxidase活化過程中所扮演的角色
補助單位
行政院國家科學委員會
計畫名稱
98 凝血刺激人類肺部纖維母細胞結締組織生長因子表現的分子機制探討
補助單位
行政院國家科學委員會
計畫名稱
98 研究複合體p85α/c-Src/p47phox的形成在PGN誘導NADPH oxidase活化過程中所扮演的角色
補助單位
臺北醫學大學
計畫名稱
97 Denbinobin 誘發人類肺腺癌細胞細胞凋亡之分子機制探討
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
97 Toll-like receptor 2-Mediated Inflammatory Mechanisms Induced by Peptidoglycan-研究複合體p85alpha/c-Src/p47phox的形成在PGN誘導NADPH oxidase活化過程中所扮演的角色
補助單位
行政院國家科學委員會
計畫名稱
96 Toll-like receptor 2-Mediated Inflammatory Mechanisms Induced by Peptidoglycan-研究複合體p85alpha/c-Src/p47phox的形成在PGN誘導NADPH oxidase活化過程中所扮演的角色(1-3)
補助單位
行政院國家科學委員會
計畫名稱
96 凝血刺激人類肺部纖維母細胞結締組織生長因子表現的分子機制探討
補助單位
行政院國家科學委員會
計畫名稱
95 血管張力素II誘發心肌細胞表現結締組織生長因子的訊息傳遞機轉---凋亡信號調節激酶的重要性
補助單位
國泰醫療財團法人國泰綜合醫院
計畫名稱
95 探討NADPH氧化酶在肽聚醣誘導RAW 264.7巨噬細胞氧化酶-2的表現中所扮演的角色
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
95 一氧化氮對樣澱粉beta胜肽誘導C6神經膠細胞凋亡之調控作用機轉探討
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
95 樣澱粉腦血管病變─樣澱粉誘導腦血管內皮細胞Bim表現之分子機制探討(1-2)
補助單位
行政院國家科學委員會
計畫名稱
95 樣澱粉腦血管病變─樣澱粉誘導腦血管內皮細胞Bim表現之分子機制探討(2-2)
補助單位
行政院國家科學委員會
計畫名稱
95 Cerebral amyloid angiopathy(樣澱粉腦血管病變)─樣澱粉誘發基質金屬蛋白酵素-9表現之轉錄機制(2-2)
補助單位
行政院國家科學委員會
計畫名稱
94 革蘭氏陽性菌細胞壁成分Peptidoglycan刺激巨噬細胞前發炎物質釋放之訊息傳遞探討3/3
補助單位
行政院國家科學委員會
計畫名稱
94 樣澱粉引發之腦血管疾病--樣澱粉BETA引發腦血管內皮細胞凋亡之分子機制探討(3/3)
補助單位
行政院國家科學委員會
計畫名稱
93 2004美洲臺灣人生物科學會─臺灣生技製藥研發策略研討會
補助單位
行政院國家科學委員會
計畫名稱
93 革蘭氏陽性菌細胞壁成分Peptidoglycan刺激巨噬細胞前發炎物質釋放之訊息傳遞探討2/3
補助單位
行政院國家科學委員會
計畫名稱
93 樣澱粉引發之腦血管疾病--樣澱粉BETA引發腦血管內皮細胞凋亡之分子機制探討(2/3)
補助單位
行政院國家科學委員會
計畫名稱
92 PI3K/Akt 路徑在脂臺口酸引發巨噬細胞iNOS表現的角色探討　　
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
92 九十三年度台北醫學大學中小企業創新育成中心專案計畫
補助單位
經濟部中小企業處運用中小企業發展基金
計畫名稱
92 革蘭氏陽性菌細胞壁成分Peptidoglycan刺激巨噬細胞前發炎物質釋放之訊息傳遞探討1/3
補助單位
行政院國家科學委員會
計畫名稱
92 樣澱粉引發隻腦血管疾病--樣澱粉BETA引發腦血管內皮細胞凋亡之分子機制探討(1/3)
補助單位
行政院國家科學委員會
計畫名稱
92 Ras-Raf-MAPK路徑在脂臺口酸引發巨噬細胞iNOS表現的角色探討
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
91 第三神經系統對肺及呼吸道之調控--緩激汰引發iNOS表現及cytokines釋放之訊號傳遞路徑及彼此間之調控機制探討
補助單位
行政院國家科學委員會
計畫名稱
90 樟芝抗發炎藥理活性成分之篩選
補助單位
偉翔生技開發股份有限公司
計畫名稱
90 第三神經系統對肺及呼吸道之調控---緩激汰引發iNOS表現及cytokines釋放之訊號傳遞路徑及彼此間之調控機制探討
補助單位
行政院國家科學委員會
計畫名稱
89 第三神經系統對肺及呼吸道之調控--緩激汰引發cytokines, iNOS, COX-2及PLA2表現的訊息傳遞路徑及彼此間的調控機制探討
補助單位
行政院國家科學委員會
計畫名稱
89 革蘭氏陽性菌細胞壁成分Lipoteichoic acid引發上皮細胞環氧酵素-2表現之訊號傳遞路徑探討(2/2)
補助單位
行政院國家科學委員會
計畫名稱
88 非膽鹼性系統對呼吸道/肺之調控--抗氧化劑對天竺鼠呼吸道之非膽鹼性神經系統的保護角色之調控(II)(2/2)
補助單位
行政院國家科學委員會
計畫名稱
88 革蘭氏陽性菌細胞壁成分Lipoteichoic acid 引發上皮細胞環氧酵素-2表現之訊號傳遞路徑探討
補助單位
行政院國家科學委員會