鄭可大(Cheng, Kur-Ta) 教授

Email
ktbot@tmu.edu.tw
現   職
生物化學暨細胞分子生物學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立台灣大學植物學研究所 博士
1990/09/01~1994/06/01
國立中興大學土壤研究所 碩士
1987/09/01~1989/06/01
國立中興大學土壤學系 學士
1979/10/01~1983/06/01

本校學術經歷

任職單位與職稱[起迄時間]
生物化學暨細胞分子生物學科教授
2014/08/01~2025/01/31
生化學科教授
2005/08/01~2014/07/31
生化學科副教授
1998/10/16~2005/07/31
生藥學研究所副教授
1995/08/01~1998/10/15

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
中草藥分子鑑定研究中心籌備處主任
2008/08/01 ~ 2014/02/19
醫學科學研究所教授
2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
中研院植物所研究助理
1989/07/01~1990/08/31
中興大學土壤系研究助理
1986/07/01~1987/08/31
中研院植物所研究助理
1985/07/01~1986/06/30

專長與研究領域

學門領域
中草藥分子鑑定
台灣藥草天然資源開發
保健食品開發
天然化妝保養品開發
抗肥胖研發
學術專長
DNA指紋分析技術
脂肪細胞增生代謝調控

論文著作

清冊下載


1. 2023 Blockade of the SRC/STAT3/BCL-2Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether . Biomedicines .2023

2. 2023 Liao CP,Hsieh YC,Lu CH,Dai WC,Yang WT,Cheng KT, Ramani MV, Subbaraju GV, Chang CC. Methoxyhispolon Methyl Ether, a Hispolon Analog, Thwarts the SRC/STAT3/BCL-2 Axis to Provoke Human Triple-Negative Breast Cancer Cell Apotosis in Vitro. . Biomedicines .2023 ;(11):2742

3. 2020 Fan HC,Hsieh YC,Li LH,Chang CC,Janousknova K,Ramani MV, Subbaraju GV, Cheng KT, Chang CC. Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/ -Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis . International Journal of Molecular Sciences .2020 ;(21):8839

4. 2018 Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set . PLoS One .2018 ;(13)

5. 2017 Lee CC,Chen PH,Ho KH,Shih CM,Cheng CH,Lin CW, Cheng KT, Liu AJ, Chen KC. The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA . PLoS ONE .2017 ;(12):1-20

6. 2017 Wu MS,Chien CC,Cheng KT,Subbaraju GV,Chen YC. Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells . The American Journal of Chinese Medicine .2017 ;(45):1649-1666

7. 2015 Lee YC,Lee CH,Tsai HP,An HW,Lee CM,Wu JC, Chen CH, Huang SH, Hwang J, Cheng KT, Leiw PL, Chen CL, Lin CM. Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer . PLoS ONE .2015 ;(10):1-19

8. 2015 Cheng KT,Wang YS,Chou HC,Chang CC,Lee CK,Juan SH. Kinsenoside-mediated lipolysis through an AMPK-dependent pathway in C3H10T1/2 adipocytes . Phytomedicine .2015 ;(22):641-647

9. 2014 Yang LY,Shen SC,Cheng KT,Subbaraju GV,Chien CC,Chen YC. Hispolon inhibition of inflammatory apoptosis through reduction of iNOS/NO production via HO-1 induction in macrophages . J Ethnopharmacol. .2014 ;(156):61-72

10. 2013 Lien GS,Chen CS,Chen WY,Huang SH,Cheng KT,Lin CM. Photoproducts of indomethacin exhibit decreased hydroxyl radical scavenging and xanthine oxidase inhibition activities . journal of food and drug analysis .2013

11. 2011 Chen CM,Wang LF,Cheng KT. Maternal Baicalin Treatment Increases Fetal Lung Surfactant Phospholipids in Rats . Evidence-Based Complementary and Alternative Medicine .2011 ;(2011)

12. 2011 Hsia CW,Shui HA,Wang CY,Yu HM,Cheng KT,Tseng MJ. Proteomics demonstration that histone H4 is a colchicine-induced retro-modulator of growth and alkaline phosphatase activity in hair follicle dermal papilla culture . Journal of Proteomics .2011 ;(74):805-816

13. 2010 Lu SH,Yen KY,Ling TY,Cheng KT,Shu JA,Au HK, Huang YH. Capacitation Suppression by Mouse Seminal Vesicle Autoantigen Involves a Decrease in Plasma Membrane Ca2þ-ATPase (PMCA)-Mediated Intracellular Calcium . Journal of Cellular Biochemistry .2010 ;(111):1188-1198

14. 2010 Xu H,Ying Y,Wang ZT,Cheng KT. Identification of Dendrobium Species by Dot Blot Hybridization Assay . Biol. Pharm. Bull. .2010 ;(33):665-668

15. 2009 Xu H,Wang ZT,Cheng KT,Wu T,Gu LH,Hu ZB. Comparison of rDNA ITS sequences and tanshinones between Salvia miltiorrhizae populations and Salvia species. . Botanical Studies .2009 ;(50):127-135

16. 2009 Lee YL,Lee MH,Chang HJ,Huang PY,Huang IJ,Cheg KT, Leu SJ. Taiwanese Native Plants Inhibit Matrix Metalloproteinase-9 Activity after Ultraviolet B Irradiation . Molecules .2009 ;(14):1062-1071

17. 2008 Lee MH,Yang YY,Tsai YH,Lee YL,Huang PY,Huang IJ, Cheng KT, Leu SJ. The effect of Chinese herbal medicines on TNF-α induced matrix metalloproteinase-1, -9 activities and interleukin-8 secretion . Botanical Studies .2008 ;(49):301-309

18. 2007 Lin SF,Tsay HS,Chou TW,Yang MJ,Cheng KT. Genetic Variation of Anoectochilus formosanus Revealed by ISSR and AFLP Analysis . Journal of Food and Drug Analysis .2007 ;(15):156-162

19. 2007 Cheng KT,Hsu FL,Chen SH,Hsieh PK,Huang HS,Lee CK, Lee MH. New constitute from Podocarpus macrophyllus var, macrophyllus shows anti-tyrosinase effect and regulates tyrosinase-related proteins and mRNA in human epidermal melanocytes . Biological and Pharmaceutical Bulletin .2007 ;(55):757-761

20. 2006 Tseng CC,Shang HF,Wang LF,Su B,Hsu CC,Kao HY, Cheng KT. Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata . Phtomedicine .2006 ;(13):366-370

21. 2005 Huang ST,Chen CT,Cheng KT,Huang SH,Chiang BH,Wang LF, Kuo HS, Lin CM. Inhibitory Effects of a Constituent from Rice Hull on Tumor Necrosis Factor-a, Prostaglandin E2, and Cyclooxygenase-2 Production in LPS-activated Mouse Macrophages . Ann. N. Y. Acad. Sci. .2005 ;(1042):387-395

22. 2005 Wang LF,Lin CM,Shih CM,Chen HJ,Su B,,Tseng CC, Gau BB, Cheng KT. Prevention of Cellular Oxidative Damage by an Aqueous Extract of Anoectochilus formosanus . Ann. N.Y. Acad. Sci. .2005 ;(1042):379-386

23. 2004 Chao SC,Hsieh IL,Lee LW,Cheng KT,Su CH. Culture of Cordyceps myrmecophila Cesati. . Fung. Sci. .2004 ;(19):53-59

24. 2004 Cheng KT,Lo SF,Lee CY,Chen CC,Tsay HS. The rDNA sequence analysis of Three Dendrobium species . Journal of Food and Drug Analysis .2004 ;(12):367-369

25. 2004 Yang SS,Cheng KT,Lin YS,Liu YW,Hou WC. Pectin Hydroxamic Acids Exhitbit Antioxidant Activities in Vitro . J ournal of Agricultural and Food Chemistry .2004 ;(52):4270-4273

26. 2004 Chao SC,Hsieh IL,Lee LW,Cheng KT,Su CH. Culture of Cordyceps myrmecophila Cesati . Fung. Sci. .2004 ;(19):53-59

27. 2004 Chen CM,Wang LF,Cheng KT,Hsu HH,Gau B,Su B. Effects of Anoectochilus formosanus Hayata extract and glucocorticoid on lung maturation in preterm rats . Phytomedicine .2004 ;(11):509-515

28. 2003 Cheng KT, Huang YC, Lin YS, Su B, Chen CM. Effects of Baicalin on the Gene Expression of Surfactant protein A in Lung Adenocarcinoma Cell Line H441 . Planta Medica .2003 ;(89):1-5

29. 2003 Su CH, Chao SC, Lee LW, Hsies IL, Cheng KT. Phylogenetic Relationships of Cordyceps Species Revealed by ITS Sequences of Ribosomal DNA . Journal of Genetics and Molecular Biology .2003 ;(14):30-40

30. 2003 Hou WC, Lin RD, Cheng KT, Hung YT, Cho CH, Chen CH.. Free Radical- Scavenging Activity of Taiwanese native plants . Phytomedicine .2003 ;(10):170-175

31. 2003 Cheng KT, Hou WC, Huang YC, Wang LF. Baicalin Induces Differential Expression of Cytochrome C Oxidase in Human Lung H441 Cell . Journal of Agricultural & Food Chemistry .2003 ;(51):7276-7279

32. 2002 Lin TC, Cheng KT, Huang JW.. Effect of clove and its major component on control of Rhizoctonia damping-off of cabbage seedlings . Plant Pathol. Bull. .2002 ;(11):189-198

33. 2000 Cheng KT, Chang HC, Huang H and Lin CT. RAPD analysis of Lycium barbarum Medicine in Taiwan Market . Botanical Bulletin of Academia Sinica .2000 ;(41):11-14

34. 2000 Borcherng Su, Leng-Fang Wang, Cheng-Chuang Tseng, Cheng-Chen Hsu, Her Huang, Chia-Ping June, Chun-Mao Lin and Kur-Ta Cheng. The effect of Anoectochilus formosanus on hepatic cytokeratin 18 of mice . Research Communications in Pharmacology and Toxicoligy .2000 ;(5):194-204

35. 2000 Cheng KT, Su BC, Chen CT and Lin CC. RAPD analysis of Astragalus Medicines in Taiwan Market . American Journal of Chinese Medicine .2000 ;(28):273-278

36. 1999 Cheng KT, June CP and Chang HC. RAPD analysis of Angelica sinensis Medicine in Taiwan Market . Chinese Pharmaceutical J .1999 ;(51):307-312

37. 1998 Cheng KT, Fu LC, Wang CS, Hsu FL and Tsay HS. Identification of Anoectochilus formosanus and Anoectochilus koshunensis species with RAPD markers. . Planta Medica .1998 ;(64):46-49

38. 1998 Young CC and Cheng KT. Genetic diverstiy of fast-and slow-growing soyhean rhizobla determined by random amplified polymorphic DNA analysis. . Biol Fertil Soils .1998 ;(26):254-256

39. 1998 Cheng KT, Su CH, Chang HC and Huang JY. Differentiation of Genuines and Counterfeits of Cordyceps species Using Random Amplified Polymorphic DNA. . Planta Medica .1998 ;(64):451-453

40. 1998 Cheng KT, Tsay HS, Chen CF and Chou TW. Determination of the Components in Yu-Ping-Feng San by RAPD Analysis. . Planta Medica .1998 ;(64):563-565

41. 1997 Cheng KT and Chou TW. Identification of Anoectochilus species with RAPD markers. . Journal of the Chinese Agricultural Chemical Society .1997 ;(35):18-25

42. 1997 Cheng KT and Chou CH. Ecotypic variation of Imperata cylindrica populations in Taiwan : I. Morphological and molecular evidences. . Botanical Bulletin of Academia Sinica .1997 ;(38):215-223

43. 1997 Cheng KT, Chang HC, Su CH and Hsu FL. Identification of dried rhizomes of Coptis species using random amplified polymorphic DNA. . Botanical Bulletin of Academia Sinica .1997 ;(38):241-244

44. 1997 Cheng KT and Chou CH. Specific RAPD Markers of Imperata cylindrica Populations in Taiwan . Journal of Genetic Molecular Biology .1997 ;(8):41-54

45. 1996 鄭可大、楊玲玲、蔡新聲. 五種中藥材去氧核醣核酸指紋分析圖譜的建立. . J Chin Med .1996 ;(7):237-239

46. 1996 Cheng KT and Liu SY. Genetic relationships in Dioscorea alata L. revealed by RAPD analysis . The Chinese Pharmaceutical Journal .1996 ;(48):197-205


1. 2004 鄭可大. 中藥分子鑑:複方中藥組分的DNA鑑別 . .2004

2. 2002 Cheng KT. Authentication of Chinese medicinal materials by DNA technology: Authentication of the components from a mixture of herbal materials . .2002

研究計畫

計畫名稱
107 山葵栽培植株主成分異硫氰酸烯丙酯的含量分析研究計畫
補助單位
台灣原鄉社會企業有限公司

計畫名稱
105 靈芝CKT-3成分及相關配方樣品之體外脂解活性測試
補助單位
友榆科技有限公司

計畫名稱
100 白藜蘆醇(Resveratrol)面膜組合配方產品功效性測試
補助單位
西西佳國際股份有限公司

計畫名稱
95 山苦瓜DMA基源之研究
補助單位
行政院農業委員會花蓮區農業改良場

計畫名稱
92 台灣野生樟芝之基源、化學成分及生物活性研究-台灣野生樟芝菌種調查及其基源之研究(1/3)
補助單位
行政院國家科學委員會

計畫名稱
91 個人DNA水晶紀念品之人體血液全DNA抽取之研發計畫
補助單位
長青樹生物科技有限公司

計畫名稱
91 金劍保養外用液原料藥材基源鑑定
補助單位
華肝基因股份有限公司

計畫名稱
91 中藥材基因資料庫的建立-薯蕷品種分子鑑定之研究
補助單位
行政院衛生署中醫藥委員會

計畫名稱
91 石斛品種分子標記的篩選
補助單位
行政院國家科學委員會

計畫名稱
91 烷基酚類清潔劑對國人主食水稻之品質及DNA突變之影響研究
補助單位
行政院國家科學委員會

計畫名稱
90 生化植保製劑產品開發(二)
補助單位
台鹽實業股份有限公司

計畫名稱
90 中藥材基因資料庫的建立:石斛及天麻品種分子鑑定研究
補助單位
行政院衛生署中醫藥委員會

計畫名稱
90 臺灣金線連優勢品系之遺傳標誌的篩選
補助單位
行政院國家科學委員會

計畫名稱
89 生益21號苧麻基源鑑定與確認之研究計畫
補助單位
生益科技股份有限公司

計畫名稱
89 藥用與保健植物--臺灣金線連鐮刀菌莖腐病抗病基因差異性表現之研究(第二年)(2/3)
補助單位
行政院國家科學委員會

計畫名稱
89 生化植保製劑產品開發(一)
補助單位
台鹽實業股份有限公司

計畫名稱
89 臺灣金線連免疫及抗腫瘤活性成分之研究
補助單位
行政院國家科學委員會