許秀蘊(Sheu, Shiow-Yunn) 名譽教授

Email
amel@tmu.edu.tw
現   職
藥物科學學科 名譽教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立臺灣大學藥學研究所 博士
2003/09~1997/01
私立臺北醫學院藥學研究所 碩士
1988/09/01~1991/06/01
私立臺北醫學院藥學系 學士
1971/09/01~1975/06/01

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科名譽教授
2020/02/01~
藥物科學學科教授
2012/02/01~2020/01/31
藥學系教授
2000/09/01~2012/01/31
藥學系副教授
1993/08/01~2000/08/31
藥學系講師
1986/08/01~1993/07/31
藥學系講師
1984/08/01~1986/07/31
藥學系講師
1982/08/01~1984/07/31
藥學系助教
1975/10/01~1982/07/31
藥學系助教
1975/08/01~1975/09/30

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥學院代理院長
2017/08/01 ~ 2017/12/31
(舊)生技醫療產業研發博士學位學程教授
2016/09/01 ~ 2017/08/31
藥學院藥事經濟研究中心主任
2015/08/06 ~ 2016/08/01
藥學院副院長
2013/09/01 ~ 2017/07/31
藥學系主任
2010/08/01 ~ 2016/07/31
藥學系主任
2007/06/01 ~ 2010/01/01
藥學系主任
2005/03/01 ~ 2005/07/31

其它經歷

任職單位與職稱[起迄時間]
無資料!

專長與研究領域

學門領域
藥學
學術專長
1.活性天然物之分離(色層分析)及結構鑑定(儀器分析)
2.抗氧化活性之測定(自由基及酵素活性)
3. 骨細胞之初代培養

論文著作

清冊下載


1. 2018 Wu FJ,Kao LT,Sheu SY,Lin HC,Chung SD. Increased risk of a herpes zoster attack in patients receiving androgen deprivation therapy for prostate cancer . Andrologia .2018 ;(50):1-5

2. 2018 Shin-Chia Tsai,Shiow-Yunn Sheu,Li-Nien Chien,Hsin-Chien Lee,Eunice Jia-Shiow Yuan,Rey-Yue Yuan. High exposure compared with standard exposure to metoclopramide associated with a higher risk of parkinsonism: a nationwide population-based cohort study . British Journal of Clinical Pharmacology .2018 ;(84):2000-2009

3. 2016 Wu FJ,Sheu SY,Lin HC,Chung SD. Increased fall risk in patients receiving androgen deprivation therapy for proatate cancer . Urology .2016 ;(95):145-150

4. 2015 Tseng IJ,Lin PY,Sheu SY,Tung WN,Lin CT,Lin MH. Characterization of Novel Aminobenzylcantharidinimides and Related Imides by proton NMR Spectra and Their Effects on NO Induction . Journal of the Chinese Chemical Society .2015 ;(62):59-63

5. 2015 Sheu SY,Ho SR,Sun JS,Chen CY,Ke CJ. Arthropod steroid hormone (20-hydroxyecdysone) suppresses IL-1Beta-induced catabolic gene expression in cartilage . BMC Complementary and Alternative Medicine .2015 ;(15):001-008

6. 2015 Sheu SY,Hong YW,Sun JS,Liu MH,Chen CY,Ke CJ. Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity . BMC Complementary & Alternative Medicine .2015 ;(15):324-332

7. 2015 Liu SL,Oyama T,Miyoshi Y,Sheu SY,Mita M,Ide T, Lindner W, Hamase K, Lee JA. Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples. . J Pharm. Biomed. Anal. .2015 ;(116):80-85

8. 2014 Wu FJ,Sheu SY,Lin HC. Osteoporosis is associated with antiepileptic drugs: a population-based study . Epileptic Disord .2014 ;(16):333-342

9. 2013 Sheu SY,Chen WS,Sun JS,Lin FH,Wu T. Biological characterization of oxidized hyaluronic acid/resveratrol hydrogel for cartilage tissue engineering . J Biomed Mater Res Part A .2013 ;(101A):3457-3466

10. 2013 Liaw CC,Chen YC,Fazary AE,Hsieh JL,Chen SY,Chien CT, Sheu SY, Kuo YH, Chiang BL, Shen YC. A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens . Phytochemistry Letters .2013 ;(6):397-402

11. 2013 Chang SF,Yang LM,Huang TJ,Chen CY,Sheu SY,Liu PC, Lin SJ. Biotransformation of dihydro isosteviol and the effects of transformed products on steroidogenic gene expression . Phytochemistry .2013 ;(95):268-276

12. 2012 Tseng IJ,Sheu SY,Chen YT,Huang CY,Lin CT,Lin PY. A simple procedure for preparation of N-thiazol, thiadiazol, pridyl and sulfanylamidocantharidinimines analogues and evaluation of their cytotoxicities against human HL-60, MCF7, Nuero-2a and A549 carcinoma cell . Chem. Pharm. Bull. .2012 ;(60):1453-1457

13. 2012 Lin PY,Yeh KS,Su CL,Sheu SY,Chen Tiffany,Ou KL, Lin MH, Lee LW. Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives . Molecules .2012 ;(17):10846-10863

14. 2012 Sheu SY,Tsai CC,Sun JS,Chen MH,Liu MH,Sun MG. Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinase pathways . Chinese Medical Journal .2012 ;(125):3646-3653

15. 2011 Lee Lyman,Sheu SY. 健保藥價管理之思維 . 健康保險期刊 .2011 ;(6):1-7

16. 2011 Hsieh TP,Sheu SY,Sun JS,Chen MH. Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKS/NF-kappaB regulated HIF-1alpha and PGE2 synthesis . Phytomedicine .2011 ;(18):176-185

17. 2011 Liu MH,Tsuang FY,Sheu SY,Sun JS,Shih CM. The protective effects of coumestrol against amyloid-beta peptide- and lipopolysaccharide-induced toxicity on mice astrocytes . Neurological Research .2011 ;(33):663-672

18. 2010 Lin-Wen Lee,Shih-Ming Chen,Chiung-Chang Lin,Shiow-Yunn Sheu,Pen-Yuan Lin. Study of the Natural Product Intermediates of Steviolbioside, Steviol, and isosteviol; O-and N-Acylated Forms of Benzotriazoyl Esters . J. Chin. Chem. Soc .2010 ;(57):0-0

19. 2010 Lin YX,Fazary AE,Chen SY,Chien CT,Kuo YH,Sheu SY, Shen YC. Illicaborins A-C, three prenylatedC6-C3 compounds from the fruits of Illicium arborescens . Food Chemistry .2010 ;(123):1105-1111

20. 2010 Yu-Ti Chen,Shin-Han Tsai,Shiow-Yunn Sheu,Li-Hsueh Tsai. Ghrelin improves lipopolysaccharide-induced gastrointestinal motility disturbances: roles of nitric oxide and prostagladin E2 . Shock .2010 ;(33):205-212

21. 2010 Hsieh TP,Sheu SY,Sun JS,Chen MH,Liu MH. Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression . Phytomedicine .2010 ;(17):414-423

22. 2010 Man-Hai Liu,Jui-Sheng Sun,Shaio-Wen Tsai,Shiow-Yunn Sheu,Ming-Homg Chen. Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation . Nutrition Research .2010 ;(30):57-65

23. 2009 Liu MH,Lin YS,Sheu SY,Sun JS. Anti-inflammatory effects of daidzein on the primary astroglial cells culture . Nutritional Neuroscience .2009 ;(12):123-134

24. 2007 Sun JS,Li YY,Liu MH,Sheu SY. Effects of coumestrol on neonatal and adult mice osteoblasts ativities . J. Biomedical Materials Research A .2007 ;(81A):214-223

25. 2006 Sun JS,Wu CX,Tsuang YH,Chen LT,Sheu SY. The in vitro effects of dehydroepiandrosterone on chondrocyte metabolism . Osteoarthritis and Cartilage .2006 ;(14):238-249

26. 2004 Lin LH,Lee LW,Sheu SY,Lin PY. Study on the stevioside analogues of steviolbioside, steviol, and isosteviol 19-alkyl amide dimers: synthesis and cytotoxic and antibacterial activity . Chemical and Pharmaceutical Bulletin .2004 ;(52):1117-1122

27. 2003 Sun JS, Dong GC, Lin CY, Sheu SY, Lin FH, Chen LT, Chang WH and Wang YJ. The effect of Gu-Sui-Bu (Drynaria fortunei J Sm) Immobolized modified calcium hydrogenphosphate on bone cell activities . Biomaterials .2003 ;(24):873-882

28. 2002 Chun-Yu Lin, An-Chieh Ho, Hsuch-Ching Chiang, Jui-Sheng Sun and Shiow-Yunn Sheu. Reactive Oxygen Scavenger Effect of Pyrimidines, Benzotriazoles and Related Compounds . Anticancer Research .2002 ;(22):937-942

29. 2002 Jui-Sheng Sun, Chun-Yu Lin, Guo-Chung Dong, Shiow-Yunn Sheu, Feng-Huei Lin, Li-Ting Chen and Yng-Jiin Wang. The effect of Gu-Sui-Bu (Drynaria fortunei J. Sm) on bone cell activities . Biomaterials .2002 ;(23):3377-3385

30. 2002 Lin CY, Sun JS, Sheu SY, Lin FH, Wang YJ and Chen LT. The effect of Chinese medicine on bone cell activities . The American Journal of Chinese Medicine .2002 ;(30):271-285

31. 2002 Wu LS, Chen JC, Sheu SY, Huang CC, Kuo YH, Chiu CH, Lian WX, Yang CJ, Kaphle K and Lin JH. Isocupressic acid blocks progesterone production from bovine luteal cells . The American Journal of Chinese Medicine .2002 ;(30):533-541

32. 2000 Leang-Shin Wu, Shiow-Yunn Sheu, Cheng-Chun Huang, Chih-Hsien Chiu, etc.. Ginseng Flowers Stimulate Progesterone Production from Bovine Luteal Cells . American Journal of Chinese Medicine .2000 ;(28):371-377

33. 1999 Sheu SY,Tsai HJ,Chiang HC. Benzophenones as xanthine oxidase inhibitors . Anticancer Research .1999 ;(19):1131-1136

34. 1999 Sun JS, Shien KM, Chiang HC, Sheu SY, Hang YS, Lu FJ and Tsuang YH. Scavenging effect of benzophenones on the oxidative stress of skeletal muscle cells. . Free Rad. Biol. Med. .1999 ;(26):1100-1107

35. 1999 Sheu SY, Tsai HJ and Chiang HC. Benzophenones as xanthine oxidase inhibitors. . Anticancer Res. .1999 ;(19):1131-1136

36. 1998 Sheu SY, Lai CH and Chiang HC. Inhibition of xanthine oxidase by purpurogallin and silymarin Group. . Anticancer Res. .1998 ;(18):263-268

37. 1997 Sheu SY, Tsuang YH, Hsu FL, Lu FJ and Chiang HC. Superoxide anion scavenger effect of Quercus glauca Thunb. in whole blood of patients with ankylosing spondylitis. . Am. J. Chin. Med. .1997 ;(25):307-315

38. 1997 Sheu SY and Chiang HC. Inhibition of xanthine oxidase by hydroxylated anthraquinones and related compounds. . Anticancer Res. .1997 ;(17):3293-3296

39. 1997 Sheu SY, Lin YC and Chiang HC. Inhibition of xanthine oxidase by synthetic cytokinin analogues. . Anticancer Res. .1997 ;(7):1043-1050

40. 1996 Sheu SY and Chiang HC. Inhibitory effects of plant growth regulators on xanthine oxidase. . Anticancer Res. .1996 ;(16):311-316

41. 1996 Sheu SY, Lin YC and Chiang HC. Inhibition of xanthine oxidase by cytokinins and related substances. . Anticancer Res. .1996 ;(16):3571-3576


1. 2010 Hsieh TP,Sun JS,Sheu SY. HEP Inhibits Lipopolysaccharide-Induced Osteoclastogenesis and Cytokine Synthesis . The 15th International Congress of Oriental Medicine .2010

2. 2009 Hsieh TP,Sheu SY,Sun JS. Icariin regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfal expression . Proceeding of 2009 Annual Congress of the Pharmacuetical Society of Taiwan .2009

3. 2009 Liu MH,Lin YS,Sheu SY,Sun JS. Anti-inflammatory effects of daidzein on primary astroglial cell culture . Proceedings of 2009 Annual Congress of the Pharmaceutical Society of Taiwan .2009

4. 2008 Tsai SW,Sun JS,Sheu SY. Effects of ICA on Chondrocytes in a Three-Dimensional Culture Model . 2008 Annual Meeting of the Pharmaceutical Society Taiwan .2008

5. 2007 Hsieh TP,Sun JS,Sheu SY. Regulation of BMP-2, SMAD4, Cbfa1/Runx2, OPG, and RANKL Expression by HEP in adult Mice Osteoblasts in vitro . 2007 Annual Meeting of the Pharmaceutical Society of Taiwan .2007


1. 2009 Sheu SY. 食品與營養毒物學 . .2009

研究計畫

計畫名稱
103 104年度「藥局管理制度及法規研究」計畫
補助單位
衛生福利部食品藥物管理署

計畫名稱
103 透明質酸與白藜蘆醇修飾之功能性奈米碳管材料在組織工程支架的研究與應用(2/2)
補助單位
行政院國家科學委員會

計畫名稱
102 透明質酸與白藜蘆醇修飾之功能性奈米碳管材料在組織工程支架的研究與應用(1/2)
補助單位
行政院國家科學委員會

計畫名稱
102 透明質酸與白藜蘆醇修飾之功能性奈米碳管材料在組織工程支架的研究與應用(1/2)
補助單位
科技部

計畫名稱
102 透明質酸與白藜蘆醇修飾之功能性奈米碳管材料在組織工程支架的研究與應用(2/2)
補助單位
科技部

計畫名稱
100 探討歷年中藥材之異常物質背景值研究及建立相關限量標準草案
補助單位
行政院衛生署中醫藥委員會

計畫名稱
100 新興濫用藥物成癮性、濫用性及社會危害性之相關文獻蒐集及彙整
補助單位
行政院衛生署食品藥物管理局

計畫名稱
97 管制藥品第一、二級品項藥物之毒性研究資料彙整
補助單位
行政院衛生署管制藥品管理局

計畫名稱
96 管制藥品第三、四級品項藥物之毒性研究資料彙整
補助單位
行政院衛生署管制藥品管理局

計畫名稱
93 台灣蒲公英之類雌激素作用在骨質疏鬆症治療之評估
補助單位
行政院衛生署中醫藥委員會

計畫名稱
92 骨碎補之類黃鹼素對骨細胞活性影響之評估
補助單位
行政院國家科學委員會

計畫名稱
90 牡丹皮抑制腫瘤轉移作用之評估
補助單位
行政院國家科學委員會

計畫名稱
88 以去活化蛋白激酵素及抗氧化酵素系統篩選模式評估龍膽瀉肝湯與當歸龍薈丸之療效
補助單位
行政院衛生署中醫藥委員會