陳怡帆(Chen, Yi-Fan) 教授

Email
evan.yifan@tmu.edu.tw
現   職
國際轉譯科學碩士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
陽明大學生命科學系暨基因體科學研究所 博士
2003/09~2009/06
國防醫學院微生物及免疫學研究所 碩士
2001/09~2003/06
中國醫藥大學醫事技術學系 學士
1996/09~2000/06

本校學術經歷

任職單位與職稱[起迄時間]
國際轉譯科學碩士學位學程副教授
2023/11/01~2023/07/31
國際轉譯科學碩士學位學程教授
2023/08/01~
轉譯醫學博士學位學程副教授
2020/02/01~2023/10/31
轉譯醫學博士學位學程助理教授
2013/11/11~2020/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
(舊)國際轉譯科學博士學位學程籌備處助理教授
2020/05/01 ~
醫學資訊研究所助理教授
2019/11/01 ~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程助理教授
2017/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
陽明大學助研究員
2013/08~2013/11
陽明大學博士後研究員
2013/07~2013/07
國家衛生研究院博士後研究員
2009/07~2013/06

專長與研究領域

學門領域
醫學之生化及分子生物
生物學之生化及分子生物
學術專長

論文著作

清冊下載


1. 2024 Chen Yi Fan,Luh Frank,Ho Yuan Soon,Yen Yun. Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials . Journal of Biomedical Science .2024 ;(31)

2. 2024 Chen HK,Wang YH,Lei CS,Guo YR,Tang MC,Tsai TF, Chen YF, Wang CH. Loss of Cisd2 exacerbates the progression of age-related hearing loss. . Aging and disease .2024

3. 2023 Gu NX,Guo YR,Lin SE,Wang YH,Lin IH,Chen YF, Yen Y. Frizzled-7 modulates Goblet and Paneth cell fate and maintains the homeostasis in intestines. . Development .2023

4. 2023 Wang BYH,Hsiao AWT,Wong N,Chen YF,Lee CW,Lee WYW. Is dexamethasone-induced muscle atrophy an alternative model for naturally aged sarcopenia model? . Journal of Orthopaedic Translation .2023

5. 2023 Wang BYH,Chen YF,Hsiao AWT,Chen WJ,Lee CW,Lee OKS. Ginkgolide B facilitates muscle regeneration via rejuvenating osteocalcin-mediated bone-muscle modulation in aged mice. . Journal of Cachexia, Sarcopenia and Muscle .2023

6. 2022 Chen WJ, Lin IH,Lee CW,Yoshioka K,Ono Y,Yan YT, Yen Y and Chen YF. Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle . npj Regenerative Medicine .2022

7. 2021 Chen WJ,Lin IH,Lee CW,Chen YF. Aged skeletal muscle retains the ability to remodel extracellular matrix for degradation of collagen deposition after muscle injury. . International Journal of Molecular Sciences .2021 ;(22):2123

8. 2021 Tzu-Heng Huang,Hsiao-Huang Chang,Yu-Ru Guo,Wei-Chiao Chang,Yi-Fan Chen. Vitamin B mitigates thoracic aortic dilation in Marfan Syndrome mice by restoring the canonical TGF-β pathway. . International Journal of Molecular Sciences .2021

9. 2021 Oscar Yuan-Jie Shen,Yi-Fan Chen,Hong-Tao Xu,Chien-Wei Lee. he Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review. . Biomedicines .2021

10. 2021 Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells . Journal of Advanced Research .2021

11. 2020 Upregulation of Cisd2 attenuates Alzheimer’s related neuronal loss in mice . Journal of Pathology .2020

12. 2020 Olie CS,van der Wal E,Domagoj C,Maton L,de Greef JC,Lin IH, Chen YF, Kareem E, Penninger JM, Kessler BM, Raz V. Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability . Scientific Reports .2020

13. 2019 Lin SJ,Chen YF,Hsu KC,Chen YL,Ko TP,Lo CF, Wang HC, Wang HC. Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticusPirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain. . Toxins .2019 ;(11)

14. 2019 Liao YT,Lin SJ,Shen BN,Cheng HP,Lin CP,Ko TP, Chen YF, Sun WT, Wang HC. Structural insights into the interaction between phytoplasmal effector causing phyllody 1 (PHYL1) and MADS transcription factor. . Plant Journal .2019

15. 2019 Wong JH,Wang YS,Nam S,Ho KH,Chang CM,Chen KC, Chen YF, Chang WC. Phthalate Plasticizer DEHP Induces Cyclooxygenase-2 Expression in AGS Carcinoma Cells. . Environmental toxicology .2019

16. 2019 Chen YF,Wang YH,Lei CS,Changou CA,Davis MA,Yen Y. Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers. . Journal of Biomedical Science .2019

17. 2019 Chen YF,Lin IH,Guo YR,Chiu WJ,Wu MS,Jia W, Yen Y.. Rrm2b deletion causes mitochondrial metabolic defects in renal tubules. . Scientific Reports .2019

18. 2018 Lin IH,Chang JL,Hua K,Huang WC,Hsu MT,Chen YF. Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression . BMC Genetics .2018 ;(19):55-67

19. 2018 Jhan MK,HuangFu WC,Chen YF,Kao JC,Tsai TT,Ho MR, Shen TJ, Tseng PC, Wang YT, Lin CF. Anti-TNF-α restricts dengue virus-induced neuropathy. . Journal of Leukocyte Biology .2018 ;(104):961-968

20. 2017 Shen ZQ,Chen YF,Chen JR,Jou YS,Wu PC,Kao CH, Wang CH, Huang YL, Chen CF, Huang TS, Shyu YC, Tsai SF, Kao LS, Tsai TF. Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma. . Cell Reports .2017 ;(21):2198-2211

21. 2017 12. Lin IH,Chen YF,Hsu MT. Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver. . PLoS One .2017

22. 2016 Teng YC,Neo JC,Wu JC,Chen YF,Kao CH,Tsai TF. Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice. . J Pathol .2016

23. 2014 Wang CH,Kao CH,Chen YF,Wei YH,Tsai TF. Cisd2 mediates lifespan: Is there an interconnection among Ca2+ homeostasis, autophagy and lifespan? . Free Radical Research .2014

24. 2014 Wang CH,Chen YF,Wu CY,Wu PC,Huang YL,Kao CH, Lin CH, Kao LS, Tsai TF and YH Wei.. Cisd2 modulates differentiation and function of adipocytes by regulating intracellular Ca2+ homeostasis. . Human Molecular Genetics .2014

25. 2013 Wiley SE,Andreyev AY,Divakaruni AS,Karisch R,Perkins G,Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN.. Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2R homeostasis. . EMBO Mol. Med. .2013

26. 2012 Wu CY,Chen YF,Wang CH,Kao CH,Zhuang HW,Chen CC, Chen LK, Kirby R, Wei YH, Tsai SF, Tsai TF. A persistent level of Cisd2 extends healthy lifespan and delays aging in mice. . Human Molecular Genetics .2012

27. 2012 Lin HC,Chen YF,Hsu WH,Yang CW,Tsai TF. Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse model. . Cancer Prevention Research (Phila) .2012

28. 2010 Chen YF,Wu CY,Kirby R,Kao CH,Tsai TF. A role for the CISD2 gene in lifespan control and human disease. . Annals of the New York Academy of Science .2010

29. 2010 Chen YF,Wu CY,Kao CH,Tsai TF. Longevity and lifespan control in mammals: Lessons from the mouse. . Ageing Research Reviews .2010

30. 2009 Chen YF,Kao CH,Chen YT,Wang CH,Wu CY,Tsai CY, Liu FC, Yang CW, Wei YH, Hsu MT, Tsai SF, Tsai TF. Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. . Genes & Development .2009

31. 2009 Chen YF,Kao CH,Kirby R,Tsai TF. Cisd2 mediates mitochondrial integrity and lifespan in mammals. . Autophagy .2009

研究計畫

計畫名稱
112 建立Rrm2b基因剔除小鼠模式用以研究中樞神經系統星狀膠質細胞增多症
補助單位
國家科學及技術委員會

計畫名稱
111 免疫療法開發計畫(V)-針對唾液酸結合免疫球蛋白凝集素的醣免疫檢查點來設計癌症免疫治療療法研究計畫
補助單位
智合精準醫學科技股份有限公司

計畫名稱
110 探討在老化過程中Rrm2b藉由調節肌肉幹細胞與微環境之間的交互作用在肌肉再生所扮演的角色
補助單位
國家科學及技術委員會

計畫名稱
108 免疫療法開發研究計畫:疾病動物模式的測試
補助單位
智合精準醫學科技股份有限公司

計畫名稱
107 核糖核?酸還原?在骨骼肌老化過程中所扮演的角色:RRM2B於修復與再生上的功能分析(3/3)
補助單位
科技部

計畫名稱
106 核糖核?酸還原?在骨骼肌老化過程中所扮演的角色:RRM2B於修復與再生上的功能分析(2/3)
補助單位
科技部

計畫名稱
105 核糖核?酸還原?在骨骼肌老化過程中所扮演的角色:RRM2B於修復與再生上的功能分析(1/3)
補助單位
科技部

計畫名稱
105 核糖核?酸還原?在骨骼肌老化過程中所扮演的角色:RRM2B於修復與再生上的功能分析(1/3)
補助單位

計畫名稱
104 阿茲海默症的治療策略:THSG可藉由減緩氧化壓力以降低類澱粉蛋白的聚集
補助單位
科技部

計畫名稱
104 老年性聽力損失: Cisd2 缺失會加速老化過程中的聽力損傷-接續性計畫
補助單位
科技部

計畫名稱
103 老年性聽力損失: Cisd2缺失會加速老化過程中的聽力損傷
補助單位
科技部

計畫名稱
103 表觀遺傳學對健康壽命調控: 尋找老化警訊的通報員
補助單位
科技部

計畫名稱
103 RRM2B基因對骨骼肌細胞分化之影響
補助單位
科技部

計畫名稱
102 MOLECULAR BASIS OF CISD2 FOR THE REGULATION OF MICE SPERM MOTILITY AND FERTILITY
補助單位
科技部

計畫名稱
102 TMU102-AE1-B37
補助單位
臺北醫學大學新聘教師計畫