| 1. |
2025
Shaw-Min Hou,Chun-Ming Yang,Wei-Chieh Huang,Ssu-Wei Cheng,Ting-Lin Yen,Chih-Wei Hsia, Cheng-Ying Hsieh, Chih-Hsuan Hsia.
Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages
. Biomolecules
.2025
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| 2. |
2025
Yu-Hao Chen ,Shin-Yi Tsao,Jing-Shiun Jan,Chih-Hao Yang,Ting-Lin Yen ,Tran Thanh Duy Linh, Saileela Annavajjula, Mantosh Kumar Satapathy, Cheng-Ying Hsieh .
Cognitive Sequelae of COVID-19: Mechanistic Insights and Therapeutic Approaches
. CNS Neurosci Ther .
.2025
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| 3. |
2023
Teng RD,Yang CH,Chung CL,Sheu JR,Hsieh CY.
Attenuation of indoxyl sulfate–induced cell damage by cinchonidine—a Cinchona alkaloid—through the downregulation of p53 signaling pathway by promoting MDM2 cytoplasmic-nuclear shuttling in endothelial cells.
. Life sciences
.2023
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| 4. |
2023
Kuan-Jung Lu,Joen-Rong Sheu,Ruei-Dun Teng,Tanasekar Jayakumar,Chi-Li Chung,Cheng-Ying Hsieh.
Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice
. International Journal of Biological Sciences
.2023
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| 5. |
2023
Kuan-Jung Lu,Chih-Hao Yang,Joen-Rong Sheu,Chi-Li Chung,Tanasekar Jayakumar,Chieh-Min Chen, Cheng-Ying Hsieh.
Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia–Exacerbated Neurological Deficits of Ischemic Stroke in Mice
. Translational Research
.2023
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| 6. |
2022
Jayakumar T,Yang CM,Yen TL,Hsu CY,Sheu JR,Hsia CW, Manubolu M, Huang WC, Hsieh CY, Hsia CH..
Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules.
. Int J Mol Sci.
.2022
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| 7. |
2022
Chiu CW, Hsieh CY,Yang CH,Tsai JH,Huang SY,Sheu JR.
Yohimbine, an α2-Adrenoceptor Antagonist, Suppresses PDGF-BB-Stimulated Vascular Smooth Muscle Cell Proliferation by Downregulating the PLCγ1 Signaling Pathway.
. Int J Mol Sci.
.2022
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| 8. |
2022
Jayakumar T,Huang CJ,Yen TL,Hsia CW,Sheu JR,Bhavan PS, Huang WC, Hsieh CY, Hsia CH..
Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells.
. Molecules
.2022
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| 9. |
2021
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism
. Autophagy
.2021
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| 10. |
2021
Kao-Wei Hung,Chao-Chien Chang ,Thanasekaran Jayakumar ,Marappan Velusamy,Chih-Wei Hsia,Nguyen Thi Thu Trang, Duen-Suey Chou, Cheng-Ying Hsieh, Chih-Hsuan Hsia.
TQ-6, a Novel Ruthenium Derivative Compound, Possesses Potent Free Radical Scavenging Activity in Macrophages and Rats
. Applied Sciences
.2021
;(11):1008
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| 11. |
2021
Chih-Wei Chiu,Chih-Hao Yang,Jie-Heng Tsai,Cheng-Ying Hsieh,Shih-Yi Huang.
Platonin, a Cyanine Photosensitizing Dye, Ameliorates Inflammatory Responses in Vascular Smooth Muscle Cells by Modulating Inflammatory Transcription Factors
. Applied Sciences
.2021
;(11)
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| 12. |
2021
Huang CJ,Huang WC,Lin WT,Shu LH,Sheu JR,Tran OT, Hsia CW, Jayakumar T, Bhavan PS, Hsieh CY, Chang CC. .
Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism.
. Int J Mol Sci.
.2021
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| 13. |
2019
Wu ZH,Tsai JH,Hsieh CY,Chen WL,Chung CL.
Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions.
. J Clin Med.
.2019
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| 14. |
2019
Sheu JR,Hsieh CY, Jayakumar T,Lin GY,Lee HN,Huang SW, Yang CH.
HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.
. J Biomed Sci.
.2019
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| 15. |
2019
Sheu JR, Hsieh CY,Jayakumar T,Tseng MF, Lee HN,Huang SW, Manubolu M, Yang CH..
A Critical Period for the Development of Schizophrenia-Like Pathology by Aberrant Postnatal Neurogenesis.
. Front Neurosci.
.2019
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| 16. |
2019
Hsieh CY,Sheu JR,Yang CH,Chen WL, Tsai JH,Chung CL.
Thrombin Upregulates PAI-1 and Mesothelial-Mesenchymal Transition Through PAR-1 and Contributes to Tuberculous Pleural Fibrosis.
. Int J Mol Sci.
.2019
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| 17. |
2018
Sheu JR,Chen ZC,Hsu MJ,Wang SH,Jung KW,Wu WF, Pan SH, Teng RD, Yang CH, Hsieh CY.
CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation.
. J Cell Mol Med
.2018
;(22):999-1013
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| 18. |
2018
Yen TL,Chang CC,Chung CL,Ko WC,Yang CH,Hsieh CY.
Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact.
. Int J Mol Sci.
.2018
;(19)
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| 19. |
2018
Li JY,Liu CP,Shiao WC,Jayakumar T,Li YS,Chang NC, Huang SY, Hsieh CY.
Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53.
. Arch Med Sci.
.2018
;(14):579-587
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| 20. |
2017
Sheu JR,Chen ZC,Jayakumar T,Chou DS,Yen TL,Lee HN, Pan SH, Hsia CH, Yang CH, Hsieh CY.
A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice.
. Sci Rep
.2017
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| 21. |
2016
Yen TL,Chen RJ,Jayakumar T,Lu WJ,Hsieh CY,Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR.
Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.
. Transl Res
.2016
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| 22. |
2016
Lu WJ,Lin KC,Liu CP,Lin CY,Wu HC,Chou DS, Geraldine P, Huang SY, Hsieh CY, Sheu JR.
Prevention of arterial thrombosis by nobiletin: in vitro and in vivo studies.
. J Nutr Biochem
.2016
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| 23. |
2015
Yang PS,Wang MJ,Jayakumar T,Chou DS,Ko CY,Hsu MJ, Hsieh CY.
Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells.
. Molecules
.2015
;(20):8198-8212
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| 24. |
2015
Das D,Wang YH,Hsieh CY,Suzuki YJ.
Major vault protein regulates cell growth/survival signalling through oxidative modifications.
. Cell Signal
.2015
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| 25. |
2014
Chang Y,Chen WF,Lin KH,Hsieh CY,Chou DS,Lin LJ, Sheu JR*, Chang CC*.
Novel bioactivity of ellagic Acid in inhibiting human platelet activation.
. Evid Based Complement Alternat Med
.2014
|
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| 26. |
2014
Chen YY,Hsu MJ,Sheu JR,Lee LW,Hsieh CY.
Andrographolide, a Novel NF-κB Inhibitor, Induces Vascular Smooth Muscle Cell Apoptosis via a Ceramide-p47phox-ROS Signaling Cascade
. Evid Based Complement Alternat Med
.2014
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| 27. |
2014
Hsieh CY,Hsiao G,Hsu MJ,Wang YH,Sheu JR.
PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells.
. J Cell Mol Med
.2014
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| 28. |
2014
Chen YY,Hsieh CY,Jayakumar T,Lin KH,Chou DS,Lu WJ, Hsu MJ, Sheu JR..
Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade.
. Sci Rep.
.2014
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| 29. |
2014
Chen YY,Hsu MJ,Hsieh CY,Lee LW,Chen ZC,Sheu JR.
Andrographolide inhibits nuclear factor-κB activation through JNK-Akt-p65 signaling cascade in tumor necrosis factor-α-stimulated vascular smooth muscle cells.
. ScientificWorldJournal
.2014
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| 30. |
2013
Jayakumar T,Hsieh CY,Lee JJ,Sheu JR.
Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.
. Evid Based Complement Alternat Med
.2013
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| 31. |
2013
Bansal G,Das D,Hsieh CY,Wang YH,Wong CM,Suzuki YJ.
IL-22 activates oxidant signaling in pulmonary vascular smooth muscle cells.
. Cell Signal
.2013
;(25):2727-2733
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| 32. |
2013
Jayakumar T,Chen WF,Lu WJ,Chou DS,Hsiao G,Hsu CY, Sheu JR*, Hsieh CY*.
A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies.
. J Nutr Biochem
.2013
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| 33. |
2012
Yen TL,Hsu CK,Lu WJ,Hsieh CY,Hsiao G,Chou DS, Wu GJ, Sheu JR.
Neuroprotective Effects of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), in Ischemic Stroke of Rats.
. J Agric Food Chem
.2012
;(60):1937-1944
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| 34. |
2011
Hsieh CY,Hsu MJ,Hsiao G,Wang YH,Huang CW,Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu JR*.
Andrographolide Enhances Nuclear Factor-{kappa}B Subunit p65 Ser536 Dephosphorylation through Activation of Protein Phosphatase 2A in Vascular Smooth Muscle Cells.
. J Biol Chem
.2011
;(286):5942-5955
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| 35. |
2011
Lu YC,Jayakumar T,Duann YF,Chou YC,Hsieh CY,Yu SY, Sheu JR, Hsiao G*.
Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells.
. J Agric Food Chem
.2011
;(59):4969-4978
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| 36. |
2011
Chang Y,Uen YH,Chen CC,Lin SC,Tseng SY,Wang YH, Sheu JR*, Hsieh CY*.
Platonin inhibited PDGF-BB-induced proliferation of rat vascular smooth muscle cells via JNK1/2-dependent signaling.
. Acta Pharmacol Sin
.2011
;(32):1337-1344
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| 37. |
2010
Chang CC,Lee JJ,Chiang CW,Jayakumar T,Hsiao G,Hsieh CY*, Sheu JR*.
Inhibitory effect of PMC, a potent hydrophilic -tocopherol derivative, on vascular smooth muscle cell proliferation: The pivotal role of PKC- translocation.
. Pharmceut Biol
.2010
;(48):938-946
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| 38. |
2010
Hsieh CY,Liu CL,Hsu MJ,Jayakumar T,Chou DS,Wang YH, Hsiao G, Sheu JR*.
Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation.
. Free Radic Biol Med
.2010
;(49):881-893
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| 39. |
2009
Chang Y,Hsieh CY,Peng ZA,Yen TL,Hsiao G,Chou DS, Chen CM, Sheu JR.
Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats.
. J Biomed Sci
.2009
;(16)
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| 40. |
2009
Chang Y,Lee JJ,Hsieh CY,Hsiao G,Chou DS,Sheu JR.
Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation.
. Mediators Inflamm
.2009
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