方致元(Fang, Chih-Yuan) 副教授

Email
d204106002@tmu.edu.tw
現   職
牙醫學系 副主任
牙醫學系 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
臺北醫學大學牙醫學系 博士
國防醫學院牙研所 臨床學組 碩士
2001/07~2005/07
國防醫學院牙醫學系 學士
1993/07~1999/07

本校學術經歷

任職單位與職稱[起迄時間]
牙醫學系副教授
2022/08/01~
牙醫學系助理教授
2019/08/01~2022/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
牙醫學系副主任
2023/02/10 ~

其它經歷

任職單位與職稱[起迄時間]
萬芳醫院主治醫師
萬芳醫院口腔顎面外科準主治醫師
2011/03/01~2016/03/31

專長與研究領域

學門領域
學術專長
口腔外科
口腔外科
口腔植體
口腔植體
口腔癌分子生物學
口腔癌分子生物學
口腔黏膜下纖維性病變
口腔黏膜下纖維性病變
口腔顎顏面整形
口腔顎顏面整形
正顎手術學
正顎手術學
電腦輔助手術
電腦輔助手術
齒顎重建
齒顎重建
檳榔醫學
檳榔醫學
顏面骨折手術
顏面骨折手術

論文著作

清冊下載


1. 2023 Tracy Yi-Hsuan Lee ,Chia-Nan Hung ,Johnson Hsin-Chung Cheng,Chih-Yuan Fang. The combination of the mandibular Köle procedure and bilateral sagittal splitting in orthognathic surgery has positive effect in esthetics and function for short-throat-length skeletal class III patient . J Dent Sci .2023 ;(18):479-481

2. 2023 Yuan Kai Ke ,Chih-Yuan Fang,Yu Cheng Cheng,Po Chih Hsuad. Management of maxillofacial gunshot injury with severe tissue avulsion . J Dent Sci .2023 ;(18):482-483

3. 2023 Hoi-Yee Chai,Kuang-Hsun Lin,Yen-Wen Huang,Chih-Yuan Fang. Use of three-dimensional-printed tooth replica for autogenous tooth transplantation at an anatomically challenging site . J Dent Sci .2023 ;(18):472-474

4. 2023 Extraction or nonextraction: Orthodontic treatment for the complete impaction of second permanent molars . journal of dental science .2023 ;(18):458-460

5. 2023 Downregulation of histone deacetylase 8 (HDAC8) alleviated the progression of oral submucous fibrosis . journal of dental science .2023 ;(18):652-658

6. 2023 Noninvasive incision design to prevent loss of attachment of adjacent implants in ridge augmentation . journal of dental science .2023 ;(18):903-904

7. 2023 Kuang-Yuan Liang,Dennis Chun-Yu Ho,Hsiu-Pin Yang,Pei-Ling Hsieh,Chih-Yuan Fang ,Lo-Lin Tsai, Shih-Chi Chao, Chia-Ming Liu, Cheng-Chia Yu. LINC01296 promotes cancer stemness traits in oral carcinomas by sponging miR-143 . journal of dental science .2023 ;(18):814-821

8. 2023 Orthodontic uprighting of horizontally impacted second mandibular molar through innovative use of springs . journal of dental science .2023 ;(18):939-941

9. 2023 Significant association of Yamamoto-Kohama classification and pathological depth of invasion with cervical lymph node metastasis in early-stage tongue squamous cell carcinoma (Stage I/II) . journal of dental science .2023 ;(18):1663-1668

10. 2023 A combo approach for vestibuloplasty in the edentulous maxilla . journal of dental science .2023 ;(18):1439-1441

11. 2023 A 10-year retrospective study on mandibular fractures in Northern Taiwan . journal of dental science .2023 ;(18):1330-1337

12. 2023 Facile bioactive transformation of magnesium alloy surfaces for surgical implant applications . Front Bioeng Biotechnol .2023

13. 2023 Comparative analysis of bonding strength between enamel and overlay of varying thicknesses following an aging test . journal of dental science .2023 ;(18):1850-1858

14. 2023 Human antigen R knockdown attenuates the invasive activity of oral cancer cells through inactivation of matrix metalloproteinase-1 gene expression . journal of dental science .2023

15. 2023 Targeting histone deacetylase 9 represses fibrogenic phenotypes in buccal mucosal fibroblasts with arecoline stimulation . journal of dental science .2023

16. 2023 Lidocaine induces epithelial‑mesenchymal transition and aggravates cancer behaviors in non‑small cell lung cancer A549 cells . Oncology Letters .2023

17. 2023 Correcting protruding maxillary appearance through one-piece Le fort I osteotomy without premolar extraction . journal of dental science .2023 ;(18):1926-1928

18. 2023 Resveratrol inhibits arecoline-induced fibrotic properties of buccal mucosal fibroblasts via miR-200a activation . journal of dental science .2023

19. 2023 Emily Sunny Lee,Meng-Chen Tsai,Jing-Xuan Lee,Chuki Wong,You-Ning Cheng,An-Chi Liu, You-Fang Liang, Chih-Yuan Fang, Chia-Yu Wu, I-Ta Lee . Bisphosphonates and Their Connection to Dental Procedures: Exploring Bisphosphonate-Related Osteonecrosis of the Jaws . Cancers .2023

20. 2022 Zhong-Lin Tsai,Chen-Yin Yongy,Yang-Che Wu,Chih-Yuan Fang. Extrapulmonary tuberculosis in the head and neck-a rare situation deserves attention . journal of dental science .2022 ;(17):1822-1824

21. 2022 Chih-Yuan Fang,Szu-Han Chen,Chun-Chung Huang,Yi-Wen Liao, Shih-Chi Chao,Cheng-Chia Yu. Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis . Pharmaceuticals .2022

22. 2022 Yun-Chieh Tsai,and Yi-June Lo,Chih-Yuan Fang,Yen-Wen Huang. Using open membrane technique with d-PTFE membrane during alveolar ridge preservation in defective socket reduces the need of guided bone regeneration . J Dent Sci .2022

23. 2022 Lu Ming Yi,Fang Chih Yuan,Hsieh Pei Ling,Liao Yi Wen,Tsai Lo Lin, Cheng Chia. miR-509 inhibits cancer stemness properties in oral carcinomas via directly targeting PlK1 . Journal of Dental Sciences .2022 ;(17):653-658

24. 2022 Downregulation of histone deacetylase 8 (HDAC8) alleviated the progression of oral submucous fibrosis . Journal of Dental Sciences .2022

25. 2022 Noninvasive incision design to prevent loss of attachment of adjacent implants in ridge augmentation . Journal of Dental Sciences .2022

26. 2022 Contralateral lymph node metastasis of a previously-treated oral squamous cell carcinoma without neck lymph node metastasis-a rare situation deserves attention . Journal of Dental Sciences .2022

27. 2022 Marginal Bone Level Evaluation of Fixed Partial Dental Prostheses Using Preformed Stock versus CAD/CAM Customized Abutments. . J Pers Med. .2022

28. 2021 Wu CT ,Shih YH ,Wu YC ,Fang CY . Using apical surgery to prepare apical bone before immediate implant placement and provisionalization in esthetic zone-a case report . Journal of dental sciences .2021

29. 2021 Huang YW,Tseng CW ,Yu CH ,Fang CY . The"wrap-guided bone regeneration (GBR)-technique” is a predicted and stable way for alveolar cleft repair and dental implant placement . Journal of dental sciences .2021

30. 2021 Yi-Hua Sun,Kuan-Chou Lin,Yoichi Ohiro, Chih-Yuan Fang. Trigeminocardiac reflex-related sudden bradycardia and hypotension can be induced by drain removal after superficial parotidectomy . Journal of Dental Sciences .2021

31. 2021 Chih-Wei Tseng,Heng-Chia Chuang,Pei-Hui Chen, Chih-Yuan Fang. How to perform immediate implant placement and provisionalization in patients with posterior bite collapse and premature contact of an anterior tooth - A case report . Journal of Dental Sciences .2021

32. 2021 Sheng-Yang Lee,Liang-Ping Lu,Tai-Chi Chen,Chih-Yuan Fang. By piezoelectric-assisted surgery, an ankylosis tooth is no more contraindication for orthodontic treatment-a case report . Journal of Dental Sciences .2021

33. 2021 Monica Wang,Kazuyo Kuribayashi Sato,Yu-Chao Chang,Chih-Yuan Fang. By primary closure with rotative palatal flap, immediate implant placement without good primary stability in a socket with labial cortical plate defects can achieve stable results . Journal of Dental Sciences .2021

34. 2021 Ming-Yung Chou,Chih-Yuan Fang,Pei-Ling Hsieh,Yi-Wen Liao,Cheng-Chia Yu,Shiuan-Shinn Lee. Depletion of miR-155 hinders the myofibroblast activities and reactive oxygen species generation in oral submucous fibrosis . Journal of the Formosan Medical Association .2021 ;(121):467-472

35. 2021 Yi-Jung Lu ,Liang-Han Chiu,Chih-Yuan Fang,Liang-Yi Tsai. Dynamic navigation optimizes endodontic microsurgery in an anatomically challenging area . Journal of Dental Sciences .2021

36. 2021 Monica Wang,Kazuyo Kuribayashi Sato,Lo-Lin Tsai,Wei Jen Chang,Yu-Chao Chang,Chih-Yuan Fang. The volume of proximal bone projection can determine the osseous contour after immediate implant placement and guided bone regeneration in severe labial bony deficiency . Journal of Dental Sciences .2021

37. 2021 Chih-Hui Shen ,Tz-Ya Hung,Monica Wang,Yu-Chao Chang,Chih-Yuan Fang. Utilizing virtual surgical planning and orthognathic surgery to correct severe facial asymmetry without orthodontic treatment . Journal of Dental Sciences .2021

38. 2021 Tsu-Yun Huang,Chih-Yuan Fang,Yuichi Ashikaga,Kuan-Chou Lin. Utilizing virtual surgical planning and three-dimensional-printed osteotomy guides in fibular free flap reconstruction can achieve a better result in mandibular osteoradionecrosis patient . Journal of Dental Sciences .2021

39. 2021 Dennis Chun-Yu Ho,Szu-Han Chen,Chih-Yuan Fang,Chang-Wei Hsieh,Pei-Ling Hsieh,Yi-Wen Liao,Cheng-Chia Yu , Lo-Lin Tsai. Paeonol inhibits profibrotic signaling and HOTAIR expression in fibrotic buccal mucosal fibroblasts . Journal of the Formosan Medical Association .2021

40. 2021 Po-Yu Yang,Dennis Chun-YuHo,Szu-Han Chen,Pei-Ling Hsiehe,Yi-Wen Liao,Lo-Lin Tsai, Cheng-Chia Yu, Chih-Yuan Fang. Down-regulation of miR-29c promotes the progression of oral submucous fibrosis through targeting tropomyosin-1 . Journal of the Formosan Medical Association .2021 ;(S0929-6646):00478-2-00478-8

41. 2021 Ming-Yi Lu,Chih-Yuan Fang,Pei-Ling Hsieh,Yi-Wen Liao,Lo-LinTsai,Cheng-ChiaYu. miR-509 inhibits cancer stemness properties in oral carcinomas via directly targeting PlK1 . Journal of Dental Sciences .2021

42. 2020 Yang CH ,Huang PC. Does periodontitis really play a role in dementia? - Novel evidence from molecular insights . journal of dental science .2020

43. 2020 Arecoline enhances miR-21 to promote buccal mucosal fibroblasts activation . Journal of the Formosan Medical Association .2020

44. 2020 Sun YH,Shih YH,Li CH,Fang CY. Rehabilitation of occlusion on a severe atrophic mandible by four implants-supported fixed conometric denture after bilateral inferior alveolar nerve repositioning . journal of dental science .2020

45. 2020 LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis . International Journal of Molecular Sciences .2020

46. 2020 Liu Wen Chi,Liu Hsueh Erh,Kao Yi Wei,Qin Lei,Lin Kuan Chou,Fang Chih Yuan,Tsai Lo Lin,Shia Ben Chang,Wu Szu Yuan,Liu Wen Chi,Liu Hsueh Erh,Kao Yi Wei,Qin Lei,Lin Kuan Chou,Fang Chih Yuan,Tsai Lo Lin,Shia Ben Chang,Wu Szu Yuan. Definitive intensity-modulated radiotherapy or surgery for early oral cavity squamous cell carcinoma: Propensity-score-matched, nationwide, population-based cohort study . Head and Neck .2020

47. 2020 Liu Wen Chi,Liu Hsueh Erh,Kao Yi Wei,Qin Lei,Lin Kuan Chou,Fang Chih Yuan,Tsai Lo Lin,Shia Ben Chang,Wu Szu Yuan,Liu Wen Chi,Liu Hsueh Erh,Kao Yi Wei,Qin Lei,Lin Kuan Chou,Fang Chih Yuan,Tsai Lo Lin,Shia Ben Chang,Wu Szu Yuan. Definitive radiotherapy or surgery for early oral squamous cell carcinoma in old and very old patients: A propensity-score-matched, nationwide, population-based cohort study . Radiotherapy and Oncology .2020 ;(151):214-221

48. 2020 Chiou Bo Jen,Chou Shan Ju,Ho Dennis Chun Yu,Fang Chih Yuan. Extraction with an electric motor-driven handpiece may still cause subcutaneous emphysema - A case report . Journal of Dental Sciences .2020

49. 2020 Lee Shiao Pieng,Hsieh Pei Ling,Fang Chih Yuan,Chu Pei Ming,Liao Yi Wen,Yu Chuan Hang,Yu Cheng Chia,Tsai Lo Lin,Lee Shiao Pieng,Hsieh Pei Ling,Fang Chih Yuan,Chu Pei Ming,Liao Yi Wen,Yu Chuan Hang,Yu Cheng Chia,Tsai Lo Lin. LINC00963 promotes cancer stemness, metastasis, and drug resistance in head and neck carcinomas via ABCB5 regulation . Cancers .2020 ;(12)

50. 2020 Fang Chih Yuan,Yu Cheng Chia,Liao Yi Wen,Hsieh Pei Ling,Ohiro Yoichi,Chu Pei Ming,Huang Yu Cheng,Yu Chuan Hang,Tsai Lo Lin,Fang Chih Yuan,Yu Cheng Chia,Liao Yi Wen,Hsieh Pei Ling,Ohiro Yoichi,Chu Pei Ming,Huang Yu Cheng,Yu Chuan Hang,Tsai Lo Lin. miR-10b regulated by Twist maintains myofibroblasts activities in oral submucous fibrosis . Journal of the Formosan Medical Association .2020 ;(119):1167-1173

51. 2020 Shia Ben Chang,Qin Lei,Lin Kuan Chou,Fang Chih Yuan,Tsai Lo Lin,Kao Yi Wei,Wu Szu Yuan,Shia Ben Chang,Qin Lei,Lin Kuan Chou,Fang Chih Yuan,Tsai Lo Lin,Kao Yi Wei,Wu Szu Yuan. Outcomes for elderly patients aged 70 to 80 years or older with locally advanced oral cavity squamous cell carcinoma: A propensity score–matched, nationwide, oldest old patient–based cohort study . Cancers .2020 ;(12)

52. 2020 Shia BC,Qin L,Lin KC,Fang CY,Tsai LL,Kao YW,Wu SY . Age comorbidity scores as risk factors for 90-day mortality in patients with a pancreatic head adenocarcinoma receiving a pancreaticoduodenectomy: A National Population-Based Study. . Cancer Med .2020

53. 2020 Shia BC,, ,Qin L,, Lin KC,Fang CY, Tsai LL,Kao YW, Wu SY. Aged 70 to 80 Years or Older with Locally Advanced Oral Cavity Squamous Cell Carcinoma: A Propensity Score-Matched, Nationwide, Oldest Old Patient-Based Cohort Study. . cancers .2020

54. 2020 Pei-Wen Peng,Jen-Chang Yang,Wei-Fang Lee,Chih-Yuan Fang,Chun-Ming Chang,I-Jan Chen,Chengpo Hsu,Tzu-Sen Yang. Effects of Heat Treatment of Selective Laser Melting Printed Ti-6Al-4V Specimens on Surface Texture Parameters and Cell Attachment . applied science .2020

55. 2019 Fang Chih Yuan,Hsia Shih Min,Hsieh Pei Ling,Liao Yi Wen,Peng Chih Yu,Wu Ching Zong,Lin Kuan Chou,Tsai Lo Lin,Yu Cheng Chia. Slug mediates myofibroblastic differentiation to promote fibrogenesis in buccal mucosa . Journal of Cellular Physiology .2019 ;(234):6721-6730

56. 2019 Fang Chih Yuan,Yu Cheng Chia,Liao Yi Wen,Hsieh Pei Ling,Lu Ming Yi,Lin Kuan Chou,Wu Ching Zong,Tsai Lo Lin. LncRNA LINC00974 activates TGF-β/Smad signaling to promote oral fibrogenesis . Journal of Oral Pathology and Medicine .2019 ;(48):151-158

57. 2019 Inhibition of HIF1A-AS1 impedes the arecoline-induced migration activity of human oral mucosal fibroblasts . Journal of the Formosan Medical Association .2019 ;(2020):879-883

58. 2018 Fang Chih Yuan,Wu Ching Zong,Chen Pei Ni,Chang Yu Chao,Chuang Chun Yi,Lai Chih Ting,Yang Shun Fa,Tsai Lo Lin. Antimetastatic potentials of salvianolic acid A on oral squamous cell carcinoma by targeting MMP-2 and the c-Raf/MEK/ERK pathway . Environmental Toxicology .2018 ;(2018):1-10

59. 2018 Su Tzu Rong,Liao Yi Wen,Hsieh Pei Ling,Tsai Lo Lin,Fang Chih Yuan,Lin Taichen,Lee Yu Hsien,Harn Horng Jyh,Yu Cheng Chia. Butylidenephthalide abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis . Environmental Toxicology .2018 ;(33):686-694

60. 2018 Chang Min Te,Lee Shiao Pieng,Fang Chih Yuan,Hsieh Pei Ling,Liao Yi Wen,Lu Ming Yi,Tsai Lo Lin,Yu Cheng Chia,Liu Chia Ming. Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling . Environmental Toxicology .2018

61. 2018 Peng Chih Yu,Wang Tung Yuan,Lee Shiuan Shinn,Hsieh Pei Ling,Liao Yi Wen,Tsai Lo Lin,Fang Chih Yuan,Yu Cheng Chia,Hsieh Ching Shui. Let-7c restores radiosensitivity and chemosensitivity and impairs stemness in oral cancer cells through inhibiting interleukin-8 . Journal of Oral Pathology and Medicine .2018

62. 2018 Fang Chih Yuan,Chen Pei Yin,Ho Dennis Chun Yu,Tsai Lo Lin,Hsieh Pei Ling,Lu Ming Yi,Yu Cheng Chia,Yu Chuan Hang. miR-145 mediates the anti-cancer stemness effect of photodynamic therapy with 5-aminolevulinic acid (ALA) in oral cancer cells . Journal of the Formosan Medical Association .2018 ;(117):738-742

研究計畫

計畫名稱
112 探討2-O-Methylmagnolol調控MKLN1-AS/YAP1致病鏈於抑制口腔黏膜下纖維化症發展之分子機制及治療應用
補助單位
國家科學及技術委員會

計畫名稱
110 以標靶MEG3/miR-181a/Egr1調控軸為標的探討褐藻醣膠防治口腔黏膜下纖維化症之分子機制及轉譯應用(1/2)
補助單位
科技部

計畫名稱
110 以標靶MEG3/miR-181a/Egr1調控軸為標的探討褐藻醣膠防治口腔黏膜下纖維化症之分子機制及轉譯應用(2/2)
補助單位
國家科學及技術委員會

計畫名稱
108 新聘教師研究補助
補助單位
臺北醫學大學