劉兆蓮(Liu, Chao-Lien) 副教授

Email
chaolien@tmu.edu.tw
現   職
醫學檢驗暨生物技術學系 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
臺灣大學病理學研究所 博士
2001~2007/01
臺灣大學病理學研究所 碩士
1996~1998
中國醫藥大學醫技系 學士
1992~1996
英國牛津大學
2022/07/03~2022/07/16

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系副教授
2021/02/01~
醫學檢驗暨生物技術學系助理教授
2013/02/01~2021/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
醫學生物科技博士學位學程籌備處助理教授
2015/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
Seattle Children's Research InstituteFellow Ph.D.
2009/10~2013/01
National Taiwan UniversityFellow Ph.D.
2007/02~2009/09
Chang Gung Memorial HospitalClinical Staff
1998/08~2001/08

專長與研究領域

學門領域
血液科腫瘤科風濕免疫及感染
醫事技術及實驗診斷
微生物及免疫學
學術專長
Immune Aging
Gene and cell therapy
Immunotherapy
Immunomodulation

論文著作

清冊下載


1. 2024 Hao-Chien Hung,Tsui-Lien Mao,Ming-Huei Fan,Guan-Zhi Huang,Ainani Priza Minhalina,Chi-Long Chen, Chao-Lien Liu. Enhancement of Tumorigenicity, Spheroid Niche, and Drug Resistance of Pancreatic Cancer Cells in Three-Dimensional Culture System . Journal of Cancer .2024 ;(15):2292-2305

2. 2024 Dito Anurogo,Chao-Lien Liu,Yu-Chu Chang,Yu-Hsiang Chang,J. Timothy Qiu. Discovery of differentially expressed proteins for CAR-T therapy of ovarian cancers with a bioinformatics analysis . Aging .2024 ;(16)

3. 2023 Hao-Chien Hung,Ming-Huei Fan,Daniel Wang,Carol H. Miao,Pong Su,Chao Lien Liu. Effect of chimeric antigen receptor T cells against protease-activated receptor 1 for treating pancreatic cancer . BMC Medicine .2023 ;(21):338

4. 2021 Chao Lien Liu,Ray-Hwang Yuan,Tsui-Lien Mao. The Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer . biomolecules .2021 ;(11)

5. 2021 Tsui-Lien Mao,Ming-Huei Fan,Nhlanhla Dlamini,Chao-Lien Liu. LncRNA MALAT1 Facilitates Ovarian Cancer Progression through Promoting Chemoresistance and Invasiveness in the Tumor Microenvironment . International Journal of Molecular Sciences .2021 ;(22)

6. 2020 Yuan-Hsi Wang,Fat-Moon Suk,Chao Lien Liu,Tzu-Lang Chen,Yuh-Ching Twu,Ming-Hua Hsu, Yi-Jen Liao. Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-kB Signaling Pathway in Hepatic Stellate Cells . Frontiers in Pharmacology .2020 ;(11)

7. 2020 Ching-Yao Yang,Ming Huei Fan,Carol H. Miao,Yi Jen Liao,Ray-Hwang Yuan,Chao Lien Liu. Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer . Molecular Therapy: Oncolytics .2020 ;(17):571-585

8. 2020 Yi-Jen Liao ,Yuan-Hsi Wang,Chao Lien Liu ,Cheng-Chieh Fang,Ming-Hua Hsu,Fat-Moon Suk. 4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF- . Applied Sciences .2020 ;(10):5941

9. 2020 Chao Lien Liu,Ying Jen Chen,Ming Huei Fan,Yi Jen Liao,Tsui Lien Mao. Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma . International Journal of Molecular Sciences .2020 ;(21):6467

10. 2020 Fu RY,Chen AC,Lyle MJ,Chen CY,Liu CL,Miao CH. CD4+T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice . Cellular Immunology .2020 ;(358):104216

11. 2020 Chen YJ, ,Liao YJ,,Tram VTN,,Lin CH,, Liao KC,,Liu CL. Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases . Life .2020 ;(10):246

12. 2019 Chao Lien Liu,Jim Jinn-Chyuan Sheu,Hsuan Ping Lin,Yung Ming Jeng,Cherry Yin Yi Chang,Chih Mei Chen, Jack Cheng, Tsui Lien Mao. The overexpression of MYST4 in human solid tumor is associated with increased aggressiveness and decreased overall survival . International Journal of Clinical and Experimental Pathology .2019 ;(12):431-442

13. 2019 Tsui Lien Mao,Carol H. Miao,Yi Jen Liao,Ying Jen Chen,Chia Yu Yeh,Chao Lien Liu. Ex Vivo Expanded Human Vr9Vd2 T-Cells Can Suppress Epithelial Ovarian Cancer Cell Growth . International Journal of Molecular Sciences .2019 ;(20):1139

14. 2019 Chao Lien Liu,Hung Wei Pan,Pao Ling Torng,Ming Huei Fan,Tsui Lien Mao. SRPX and HMCN1 regulate cancer-associated fibroblasts to promote the invasiveness of ovarian carcinoma. . Oncology Reports .2019 ;(42):2706-2715

15. 2019 Fat-Moon Suk*, Chao Lien Liu*,Ming-Hua Hsu,Yu-Ting Chuang,Jack P. Wang,Yi-Jen Liao. Treatment with a new benzimidazole derivative bearing a pyrrolidine side chain overcomes sorafenib resistance in hepatocellular carcinoma . Scientific Reports .2019 ;(9):17259

16. 2019 Yuan-Hsi Wang,Chao Lien Liu,Wan-Chun Chiu,Yuh-Ching Two,Yi-Jen Liao. HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma . Cancers .2019 ;(11):1876

17. 2017 Mao T. L. ,Fan K. F. ,Liu C. L. . Targeting the CXCR4/CXCL12 axis in treating epithelial ovarian cancer . Gene Therapy .2017 ;(24):621-629

18. 2016 Chao Lien Liu,Meghan J. Lyle,Simon C. Shin,Carol H. Miao. Strategies to target long-lived plasma cells for treating hemophilia A inhibitors . Cellular Immunology .2016 ;(301):65-73

19. 2016 Chao Lien Liu,Meghan J. Lyle,Simon C. Shin,Carol H. Miao. The dataset from administration of single or combined immunomodulation agents to modulate anti-FVIII antibody responses in FVIII plasmid or protein primed hemophilia A mice . Data in Brief .2016 ;(7):973-980

20. 2014 Chao Lien Liu,Peiqing Ye,Jacqueline Lin,Che'rie L. Butts,Carol H. Miao. Anti-CD20 as the B cell targeting agent in a combined therapy to modulate anti-factor VIII responses in hemophilia A inhibitor mice . Frontiers in Immunology .2014 ;(4):1-8

21. 2014 Chao lien Liu,Peiqing Ye,Jacqueline Lin,Carol H. Miao. Long-term tolerance to factor VIII is achieved by administration of IL-2/IL-2mAb complexes and low dosages of factor VIII . J. Thrombosis Haemostasis .2014 ;(12):921-931

22. 2011 Chao Lien Liu,Peiqing Ye,Benjamin C. Yen,Carol H. Miao. In vivo expansion of regulatory T cells with IL-2/IL-2 mAb complexes privets anti-factor VIII immune responses in hemophilia A mice treated with factor VIII plasmid-mediated gene therapy . Molecular Therapy .2011 ;(19):1511-1520

23. 2007 Liu CL,Yu IS,Pan HW,Lin SW,Hsu HC. L2dtl is essential for cell survival and nuclear division in early mouse embryonic development . J. Biol. Chem. .2007 ;(282):1109-1118

24. 2006 Pan HW,Chou HY,Liu SH,Peng SY,Liu CL,Hsu HC. Role of L2DTL, Cell Cycle-Regulated Nuclear and Centrosome Protein, in Aggressive Hepatocellular Carcinoma . Cell Cycle .2006 ;(5):2676-2687

25. 2002 Liu SH,Lin CY,Peng SY,Jeng YM,Pan HW,Lai PL, Liu CL, Hsu HC. Down-regulation of annexing A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation . Am J Pathol .2002 ;(160):1831-1837

研究計畫

計畫名稱
113 利用CAR相關的治療策略清除衰老細胞用於緩解老化與老化相關疾病
補助單位
國家科學及技術委員會

計畫名稱
112 How MALAT-1 Regulate Immune Response and Stemness in Ovarian Tumor Microenvironment
補助單位
國家科學及技術委員會

計畫名稱
111 CDK Inhibitor-Mediated PD-L1 Upregulation Enhances OC Responsiveness to CAR-Based Regimen Targeting
補助單位
國家科學及技術委員會

計畫名稱
110 嵌合抗原受體T細胞用於治療人類卵巢癌的免疫療法(3/3)
補助單位
科技部

計畫名稱
109 嵌合抗原受體T細胞用於治療人類卵巢癌的免疫療法(2/3)
補助單位
科技部

計畫名稱
108 嵌合抗原受體T細胞用於治療人類卵巢癌的免疫療法(1/3)
補助單位
科技部

計畫名稱
107 建構抗免疫監測點抑制因子PD1 與PDL1的嵌合抗原受體T 細胞來治療胰臟癌(3/3)
補助單位
科技部

計畫名稱
106 建構抗免疫監測點抑制因子PD1 與PDL1的嵌合抗原受體T 細胞來治療胰臟癌(2/3)
補助單位
科技部

計畫名稱
105 抗免疫監測點抑制因子PD1 與PDL1的嵌合抗原受體修飾性γδ-T細胞用於治療卵巢癌療效之探討
補助單位
科技部

計畫名稱
105 建構抗免疫監測點抑制因子PD1 與PDL1的嵌合抗原受體T 細胞來治療胰臟癌(1/3)
補助單位
科技部

計畫名稱
105 建構抗免疫監測點抑制因子PD1 與PDL1的嵌合抗原受體T 細胞來治療胰臟癌(1/3)
補助單位

計畫名稱
103 IN-VITRO EXPANSION OF ΓΔ-T CELLS IN TREATING OVARIAN CANCER
補助單位
科技部

計畫名稱
103 針對長生型血漿細胞來治療產生抑制性抗體的A型血友病人之新穎策略(2/2)
補助單位
行政院國家科學委員會

計畫名稱
102 針對長生型血漿細胞來治療產生抑制性抗體的A型血友病人之新穎策略(1/2)
補助單位
行政院國家科學委員會

計畫名稱
102 針對長生型血漿細胞來治療產生抑制性抗體的A型血友病人之新穎策略(1-2)
補助單位
科技部

計畫名稱
102 針對長生型血漿細胞來治療產生抑制性抗體的A型血友病人之新穎策略(2/2)
補助單位
科技部

計畫名稱
102 TMU102-AE1-B17
補助單位
臺北醫學大學新聘教師計畫