郭光泰(Kuo, Kuang-tai) 教授

Email
ktkuo@tmu.edu.tw
現   職
外科學科 主任
外科學科 教授
器官移植研究中心 副主任

學經歷

學 歷

畢業學校與學位[修業時間]
陽明大學臨床醫學研究所 博士
2005/09~2011/12
台灣大學醫學系 學士
1990/09~1997/06

本校學術經歷

任職單位與職稱[起迄時間]
外科學科教授
2022/08/01~
外科學科副教授
2019/02/01~2022/07/31
外科學科助理教授
2014/07/01~2019/01/31
外科學科助理教授
2012/11/01~2013/06/30

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
外科學科主任
2024/02/01 ~
器官移植研究中心副主任
2022/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
雙和醫院主治醫師
慈濟台北分院主治醫師
2004/11/01~2010/05/10
羅東博愛醫院主治醫師
2003/10/01~2004/09/30
台北榮總住院醫師
1999/07/01~2003/09/30
林口長庚醫院住院醫師
1998/07/01~1999/06/30
署立台北醫院住院醫師
1997/07/01~1998/06/30

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2024 Wu YC,Huang CS,Hsieh MS,Huang CM,Setiawan SA,Yeh CT, Kuo KT, Liu SC. Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis . Aging (Albany NY) .2024 ;(16):627-647

2. 2024 Lai SW,Cheng YC,Kiu KT,Yen MH,Chen YW,,Yadav VK, Yeh CT, Kuo KT, Chang TC. PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance . Aging (Albany NY) .2024 ;(16):1620-1639

3. 2023 Tiong TY,Chan ML, Wang CH,Yadav VK,Pikatan NW,Fong IH, Yeh CT, Kuo KT, Huang WC. Exosomal miR-21 determines lung-to-brain metastasis specificity through the DGKB/ERK axis within the tumor microenvironment . Life Sciences .2023 ;(329):1-13

4. 2022 Kuo KT,Lin CH,Wang CH,Pikatan NW,Yadav VK,Fong IH, Yeh CT, Lee WH, Huang WC. HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection Against Oxidative Stress Through Interaction with HER2 in Non–Small-Cell Lung Cancer. . Int J Mol Sci .2022 ;(23):1-21

5. 2022 Chen CC,Kuo KT,Chang SC,Liu SH. Pseudomyocardial Infarction: An Atypical Presentation of Chest Wall Necrotizing Fasciitis. . Int J Infect Dis .2022 ;(114):192-194

6. 2022 Lin YK,Yeh CT,Kuo KT,Fong IH,Kounis NG,Hu P, Hung MY. Apolipoprotein (a)/Lipoprotein(a)-induced oxidative-inflammatory α7-nAChR/p38 MAPK/IL-6/RhoA-GTP signaling axis and M1 macrophage polarization contribute to development of coronary artery spasm. . Oxid Med Cell Longev .2022 ;(2022):1-26

7. 2022 Chen JT,Wu YM,Tiong TY,Cata JP,Kuo KT,Li CC, Liu HY, Cherng YG, Wu HL, Tai YH. Spectral entropy monitoring accelerates the emergence from sevoflurane anesthesia in thoracic surgery: A randomized controlled trial. . J Clin Med .2022 ;(11):1-11

8. 2022 Tiong TY,Weng PW,Wang CH,Setiawan SA,Yadav VK,Pikatan NW, Fong IH, Yeh CT, Hsu CH, Kuo KT. Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells. . Int J Mol Sci .2022 ;(23):1-18

9. 2022 Hsu CH,Ma HP,Ong JR,Hsieh MS,Yadav VK,Yeh CT, Chao TY, Lee WH, Huang WC, Kuo KT, Fong IH, Lin CC, Su CM.. Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression. . Dis Markers .2022 ;(2022):1-16

10. 2022 Hsu CH,Ma HP,Ong JR,Hsieh MS,Yadav VK, Yeh CT, Chao TY, Lee WH, Huang WC, Kuo KT, Fong IH, Lin CC, Su CM. Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression . Disease Markers .2022 ;(2022):1-16

11. 2021 Chang NC,Yeh CT,Lin YK,Kuo KT,Fong IH,Kounis NG, Hu P, Hung MY.. Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways. . Antioxidants .2021 ;(10):1-19

12. 2021 Liu SC,Bamodu OA,Kuo KT,Fong IH,Lin CC,Yeh CT, Chen SG. Adipose-derived stem cell induced-tissue repair or wound healing is mediated by the concomitant upregulation of miR-21 and miR-29b expression and activation of the AKT signaling pathway. . Arch Biochem Biophys .2021 ;(705):1-10

13. 2021 Pai S,Yadov VK,Kuo KT,Lin CS,Chien MS,Lee WH, M Hsiao, Yeh CT, Tsai JT. PDK1 inhibitor BX795 improves cisplatin and radio-efficacy in oral squamous cell carcinoma by downregulating the PDK1/CD47/Akt-mediated glycolysis signalling pathway. . Int J Mol Sci .2021 ;(22):1-24

14. 2021 Yeh CT,Chen TT,Satriyo PB,Wang CH,Wu ATH,Chao TY, Lee KY, Hsiao M, Wang LS, Kuo KT. Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small cell lung carcinoma . Oncogenesis .2021 ;(10):1-13

15. 2021 Huang WC,Yadav VK,Cheng WH,Wang CH,Hsieh MS,Huang TY, Lin SF, Yeh CT, Kuo KT. The MEK/ERK/miR-21 signaling is critical in Osimertinib resistance in EGFR-mutant non-small cell lung cancer cells . Cancers .2021 ;(13):1-17

16. 2021 Lin YK,Yeh CT,Kuo KT,Yadav VK,Fong IH,Kounis NG, Hu P, Hung MY. Pterostilbene increases LDL metabolism in HL-1 cardiomyocytes by modulating the PCSK9/HNF1α/SREBP2/LDLR signaling cascade, upregulating epigenetic control of hsa-miR-335 and hsa-miR-6825, and increasing LDL receptor expression . Antioxidants (Basel) .2021 ;(10):1-17

17. 2019 Huang WC,Kuo KT,Wang CH,Yeh CT,Wang Y. Cisplatin resistant lung cancer cells promoted M2 polarization of tumor-associated macrophages via the Src/CD155/MIF functional pathway . J Exp Clin Cancer Res .2019 ;(38):1-17

18. 2019 Huang WC,Kuo KT,Bamodu OA,Lin YK,Wang CH,Lee KY, Wang LS, Yeh CT, Tsai JT. Astragalus polysaccharide (PG2) ameliorates cancer symptom clusters, as well as improves quality of life in patients with metastatic disease, through modulation of the inflammatory cascade . Cancers .2019 ;(11):1-13

19. 2019 Bamodu OA,Kuo KT,Wang CH,Huang WC,Wu ATH,Tsai JT, Lee KY, Yeh CT, Wang LS. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer . Nutrients .2019 ;(11):1-19

20. 2018 Kuo KT,Huang WC,Bamodu OA,Lee WH,Wang CH,Hsiao M, Wang LS, Yeh CT. Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor . Clinical Epigenetics .2018 ;(10):1-12

21. 2018 Bamodu OA,Kuo KT,Yuan LP,Cheng WH,Lee WH,Ho YS, Chao TY, Yeh CT. HDAC inhibitor suppresses proliferation and tumorigenicity of drug-resistant chronic myeloid leukemia stem cells through regulation of hsa-miR-196a targeting BCR/ABL1. . Experimental Cell Research .2018 ;(370):519-530

22. 2018 Bamodu OA,Yang CK,Cheng WH,Tzeng DTW,Kuo KT,Huang CC, Deng L, Hsiao M, Lee WH, Yeh CT. 4-Acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-miR-324 re-expression. . Cancers .2018 ;(10):1-21

23. 2018 Chen JH,Kuo KT,Bamodu OA,Lin YC,Yang RB,Yeh CT, Chao TY. Upregulated SCUBE2 expression in breast cancer stem cells enhances triple negative breast cancer aggression through modulation of notch signaling and epithelial-to-mesenchymal transition. . Experimental Cell Research .2018 ;(370):444-453

24. 2018 Lin CS,Bamodu OA,Kuo KT,Huang CM,Liu SC,Wang CH, Tzeng YM, Chao TY, Yeh CT. Investigation of Ovatodiolide, a Macrocyclic Diterpenoid, as a potential inhibitor of Oral Cancer Stem-Like Cells Properties via the Inhibition of the JAK2/STAT3/JARID1B Signal Circuit. . Phytomedicine .2018 ;(46):93-103

25. 2018 Liu M,Bamodu OA,Kuo KT,Lee WH,Lin YK,Wu ATH, M H, Tzeng YM, Yeh CT, Tsai JT. Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/ß-Catenin Signaling. . American Journal of Chinese Medicine .2018 ;(46):891-910

26. 2018 Huang WC,Kuo KT,Adebayo BO,Wang CH,Chen YJ,Jin K, Tsai TH, Yeh CT. Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β- catenin /STAT3 axis signalling pathway in human non-small cell lung carcinomas. . The Journal of Nutritional Biochemistry .2018 ;(54):140-150

27. 2016 Chiu CF,Chang YW,Kuo KT,Shen YS,Liu CY,Yu YH, Cheng CC, Lee KY, Chen FC, Hsu MK, Kuo TC, Ma JT, Su JL. NF-κB-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance . Proc Natl Acad Sci U S A .2016 ;(113):E2526-E2535

28. 2016 Kuo KT,Chen CL,Chou TY,Yeh CT,Lee WH,Wang LS. Jul16 Nm23H1 mediates tumor invasion in esophageal squamous cell carcinoma by regulation of CLDN1 through the AKT signaling . Oncogenesis .2016 ;(5):1-9

29. 2016 Su CM,Chang TY,Hsu HP,Lai HH,Li JN,Lyu YJ, Kuo KT, Huang MT, Su JL, Chen PS. A novel application of E1A in combination therapy with EGFR-TKI treatment in breast cancer . Oncotarget .2016

30. 2016 Kuo TC,Chen CK,Hua KT,Yu P,Lee WJ,Chen MW, Jeng YM, Chien MH, Kuo KT, Hsiao M, Kuo ML. Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells . Cancer Lett .2016 ;(383):282-294

31. 2013 Huang CW,Kuo KT,Lin CM,Shih CW,Kao KC,Huang CT. Clinical presentation . Thorax .2013 ;(68):980-981

32. 2012 Kuo KT,Chou TY,Hsu HS,Chen WL,Wang LS. Prognostic Significance of NBS1 and Snail Expression in Esophageal Squamous Cell Carcinoma . Annals of Surgical Oncology .2012 ;(19):549-557

33. 2012 Chen WL,Kuo KT,Chou TY,Chen CL,Wang CH,Wei YH, Wang LS. The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis . BMC Cancer .2012 ;(12):1-13

研究計畫

計畫名稱
113 標靶EYA2-TEAD4-OMA1訊號軸調控粒線體活性以克服頑固型耐藥休眠肺癌細胞的治療抗性(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 標靶EYA2-TEAD4-OMA1訊號軸調控粒線體活性以克服頑固型耐藥休眠肺癌細胞的治療抗性(1/3)
補助單位
國家科學及技術委員會

計畫名稱
111 開發治療非小細胞肺癌藥物的新策略:針對頑固型耐藥休眠細胞內EYA2/ BRD4訊號軸標靶療法
補助單位
國家科學及技術委員會

計畫名稱
110 將BTK-ITK途徑作為標靶以克服肺癌治療的抗藥性以及抑制腦轉移的策略(3/3)
補助單位
科技部

計畫名稱
109 將BTK-ITK途徑作為標靶以克服肺癌治療的抗藥性以及抑制腦轉移的策略(2/3)
補助單位
科技部

計畫名稱
108 將BTK-ITK途徑作為標靶以克服肺癌治療的抗藥性以及抑制腦轉移的策略(1/3)
補助單位
科技部

計畫名稱
107 探討BTK在抗藥性肺癌的角色並開發新的治療對策
補助單位
科技部

計畫名稱
104 組蛋白去甲基?JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(2/2)
補助單位
科技部

計畫名稱
104 組蛋白去甲基酶JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(2/2)
補助單位
科技部

計畫名稱
103 組蛋白去甲基酶JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)
補助單位
科技部

計畫名稱
103 組蛋白去甲基?JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)
補助單位
科技部

計畫名稱
101 探討EP2受體在食道鱗狀上皮細胞癌誘發之上皮間質轉化之調節機轉
補助單位
行政院國家科學委員會